Aliases for SH2D3C Gene
External Ids for SH2D3C Gene
Previous GeneCards Identifiers for SH2D3C Gene
This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
GeneCards Summary for SH2D3C Gene
SH2D3C (SH2 Domain Containing 3C) is a Protein Coding gene. Diseases associated with SH2D3C include eastern equine encephalitis and venezuelan equine encephalitis. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and SH3/SH2 adaptor activity. An important paralog of this gene is SH2D3A.
UniProtKB/Swiss-Prot for SH2D3C Gene
Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration (By similarity).