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SH2D3C Gene

protein-coding   GIFtS: 59
GCID: GC09M130501

SH2 Domain Containing 3C

(Previous name: SH2 domain-containing 3C)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SH2 Domain Containing 3C1 2     SH2 Domain-Containing 3C1
NSP32 3 5     CHAT2
Novel SH2-Containing Protein 32 3     PRO340882
SHEP12 3     SH2 Domain-Containing Protein 3C2
SH2 Domain-Containing Eph Receptor-Binding Protein 12 3     

External Ids:    HGNC: 168841   Entrez Gene: 100442   Ensembl: ENSG000000953707   OMIM: 6047225   UniProtKB: Q8N5H73   

Export aliases for SH2D3C gene to outside databases

Previous GC identifers: GC09M121615 GC09M122147 GC09M123954 GC09M125876 GC09M127580 GC09M129540 GC09M100117


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SH2D3C Gene:
This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The
encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like
domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate.
Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Nov
2011)

GeneCards Summary for SH2D3C Gene:
SH2D3C (SH2 domain containing 3C) is a protein-coding gene. Diseases associated with SH2D3C include western equine encephalitis, and eastern equine encephalitis. GO annotations related to this gene include SH3/SH2 adaptor activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is SH2D3A.

UniProtKB/Swiss-Prot: SH2D3_HUMAN, Q8N5H7
Function: Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is
required to induce membrane ruffling and promote EGF-dependent cell migration (By similarity)

Gene Wiki entry for SH2D3C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SH2D3C gene promoter:
         p53   p300   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SH2D3C promoter sequence
   Search Chromatin IP Primers for SH2D3C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SH2D3C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q33.1-q33.3

SH2D3C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SH2D3C gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M130501:  view genomic region     (about GC identifiers)

Start:
130,500,596 bp from pter      End:
130,541,048 bp from pter
Size:
40,453 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SH2D3_HUMAN, Q8N5H7 (See protein sequence)
Recommended Name: SH2 domain-containing protein 3C  
Size: 860 amino acids; 94411 Da
Subunit: Interacts with PTK2B. Interacts with NEDD9/HEF1 (By similarity). Interacts (via C-terminus) with
BCAR1/CAS
Sequence caution: Sequence=AAQ88456.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for SH2D3C:
3T6G (3D)    
Secondary accessions: A8K5S8 E9PG48 Q5HYE5 Q5JU31 Q6UY42 Q8N6X3 Q9Y2X5
Alternative splicing: 6 isoforms:  Q8N5H7-1   Q8N5H7-2   Q8N5H7-3   Q8N5H7-4   Q8N5H7-5   Q8N5H7-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SH2D3C: NX_Q8N5H7

Explore proteomics data for SH2D3C at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SH2D3C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001136003.1  NP_001136004.1  NP_001136005.1  NP_001136006.1  NP_001239263.1  NP_005480.2  NP_733745.1  

    ENSEMBL proteins: 
     ENSP00000362374   ENSP00000388536   ENSP00000317817   ENSP00000401641   ENSP00000413760  
     ENSP00000362373   ENSP00000362371   ENSP00000394632  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    3 InterPro protein domains:
     IPR023578 Ras_GEF_dom
     IPR001895 RasGRF_CDC25
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q8N5H7

    ProtoNet protein and cluster: Q8N5H7

    2 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001895 Guanine-nucleotide dissociation stimulator CDC25


    UniProtKB/Swiss-Prot: SH2D3_HUMAN, Q8N5H7
    Domain: The C-terminal Cdc25-homology/Ras-GEF domain adopts a closed conformation rendering it incapable of
    carrying out canonical exchange factor function, this closed conformation is required for interaction with BCAR1
    Similarity: Contains 1 Ras-GEF domain
    Similarity: Contains 1 SH2 domain


    SH2D3C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SH2D3_HUMAN, Q8N5H7
    Function: Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is
    required to induce membrane ruffling and promote EGF-dependent cell migration (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity TAS10187783
    GO:0005085guanyl-nucleotide exchange factor activity IEA--
    GO:0005515protein binding ----
         
    SH2D3C for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SH2D3C:
     Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory 

         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Sh2d3c):
     behavior/neurological  cellular  endocrine/exocrine gland  hematopoietic system  immune system 
     mortality/aging  nervous system  no phenotypic analysis  reproductive system 

    SH2D3C for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sh2d3ctm1.1Ebp for SH2D3C

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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SH2D3C
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    miRNA
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    miRTarBase miRNAs that target SH2D3C:
    hsa-mir-335-5p (MIRT017860)

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    8 qRT-PCR Assays for microRNAs that regulate SH2D3C:
    hsa-miR-561 hsa-miR-324-3p hsa-miR-128 hsa-miR-3681* hsa-miR-548t hsa-miR-342-5p hsa-miR-493* hsa-miR-548n
    SwitchGear 3'UTR luciferase reporter plasmidSH2D3C 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SH2D3_HUMAN, Q8N5H7: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity).
    Note=Associated with the membrane when EGF-stimulated. Found at ruffling membranes (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion2
    nucleus2
    endoplasmic reticulum1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IEA--
    GO:0016020membrane IEA--

    SH2D3C for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SH2D3C About    
    See pathways by source

    SuperPathContained pathways About
    1EGFR1 Signaling Pathway
    EGFR1 Signaling Pathway


    1 BioSystems Pathway for SH2D3C
        EGFR1 Signaling Pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SH2D3C
    Interactions:

        GeneGlobe Interaction Network for SH2D3C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for SH2D3C (Q8N5H72, 3 ENSP000003178174) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EFSO432812, 3, ENSP000002167334MINT-66753 I2D: score=5 STRING: ENSP00000216733
    SNCAIPQ9Y6H52, 3, ENSP000002613684MINT-64300 I2D: score=4 STRING: ENSP00000261368
    BCAR1P569453, ENSP000001623304I2D: score=2 STRING: ENSP00000162330
    NEDD9Q145113, ENSP000003687594I2D: score=2 STRING: ENSP00000368759
    CARD11Q9BXL73, ENSP000003801504I2D: score=1 STRING: ENSP00000380150
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007254JNK cascade TAS10187783
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0009967positive regulation of signal transduction TAS10187783

    SH2D3C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SH2D3C (SH2D3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SH2D3C gene (7 alternative transcripts): 
    NM_001142531.1  NM_001142532.1  NM_001142533.1  NM_001142534.1  NM_001252334.1  NM_005489.3  NM_170600.2  

    Unigene Cluster for SH2D3C:

    SH2 domain containing 3C
    Hs.306412  [show with all ESTs]
    Unigene Representative Sequence: NM_170600
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373277(uc004bsa.3) ENST00000420366(uc004bry.3) ENST00000314830(uc004bsd.1 uc004bsc.3)
    ENST00000468969 ENST00000484160 ENST00000471939 ENST00000440630 ENST00000464239
    ENST00000488685 ENST00000414380 ENST00000373276(uc004bsb.3) ENST00000373274(uc010mxo.3)
    ENST00000429553(uc004brz.4 uc011mak.2)
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate SH2D3C:
    hsa-miR-561 hsa-miR-324-3p hsa-miR-128 hsa-miR-3681* hsa-miR-548t hsa-miR-342-5p hsa-miR-493* hsa-miR-548n
    SwitchGear 3'UTR luciferase reporter plasmidSH2D3C 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH2D3C
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      QuantiTect SYBR Green Assays in human, mouse, rat SH2D3C
      QuantiFast Probe-based Assays in human, mouse, rat SH2D3C

    Additional mRNA sequence: 

    AF124251.1 AJ420431.1 AK000861.1 AK056068.1 AK096983.1 AK128287.1 AK291393.1 AK292041.1 
    AK292718.1 AK294386.1 AK311510.1 AY358089.1 AY358440.1 BC027962.1 BC032365.1 BX647905.1 

    16 DOTS entries:

    DT.40306903  DT.95089397  DT.100787946  DT.412045  DT.95089374  DT.101982497  DT.101956083  DT.121174286 
    DT.97799195  DT.121174248  DT.121174254  DT.121174275  DT.92421650  DT.92421651  DT.97839395  DT.91960749 

    Selected AceView cDNA sequences (see all 109):

    AW264171 BX647905 BI833455 BU738118 CA389145 AI814519 AI676011 BI821749 
    BQ693987 AI239541 CB269008 BM542752 AI472242 BG757892 AI799905 AK056068 
    BI821487 BM457354 AA234642 AI658523 BC027962 BI489573 AK096983 AI828947 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SH2D3C (see all 19)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^
    SP1:                          -     -                             -     -     -     -     -     -     -     -     -           -     -     -     -     -     -   
    SP2:                                                                                      -     -     -     -     -           -     -     -     -     -     -   
    SP3:                                                                                                                                                  -     -   
    SP4:                          -     -           -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   
    SP5:                                                                                                              -           -     -     -     -     -     -   

    ExUns: 13a · 13b · 13c ^ 14a · 14b · 14c · 14d · 14e · 14f · 14g ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b
    SP1:  -           -                                         -                                                               
    SP2:  -           -                                         -                                                               
    SP3:  -           -                                         -                                                               
    SP4:  -     -     -     -     -     -     -     -     -     -     -     -     -                                             
    SP5:  -           -                                         -                                                               


    ECgene alternative splicing isoforms for SH2D3C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SH2D3C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATTTCTTT
    SH2D3C Expression
    About this image


    SH2D3C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Endothelium (Cardiovascular System)
             Endothelial-like cells
     
     Thymus (Hematopoietic System)
    SH2D3C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SH2D3C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.306412

    UniProtKB/Swiss-Prot: SH2D3_HUMAN, Q8N5H7
    Tissue specificity: Ubiquitously expressed

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SH2D3C gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sh2d3c1 , 5 SH2 domain containing 3C1, 5 85.5(n)1
    87.26(a)1
      2 (22.09 cM)5
    273871  NM_013781.31  NP_038809.11 
     327210555 
    chicken
    (Gallus gallus)
    Aves SH2D3C1 SH2 domain containing 3C 71.42(n)
    70.89(a)
      417225  XM_415508.4  XP_415508.4 
    lizard
    (Anolis carolinensis)
    Reptilia SH2D3C6
    SH2 domain containing 3C
    57(a)
    1 ↔ 1
    GL344184.1(2372-52076)
    African clawed frog
    (Xenopus laevis)
    Amphibia sh2d3c-prov2 SH2 domain containing 3C 74.88(n)    BC041733.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc564902 similar to SH2 domain containing 3C 72.3(n)   394051  BC049321.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG90983 SH3/SH2 adaptor protein 35(a)   26B3   --


    ENSEMBL Gene Tree for SH2D3C (if available)
    TreeFam Gene Tree for SH2D3C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SH2D3C gene
    SH2D3A2  BCAR32  
    3 SIMAP similar genes for SH2D3C using alignment to 4 protein entries:     SH2D3_HUMAN (see all proteins):
    SHC3    BCAR3    SH2D3A

    SH2D3C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SH2D3C (see all 829)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1405101631,2
    C--100136420(+) ACCCA-/GATGAT
    GATGATGAT
    GATGA
    5 -- int10--------
    rs120022691,2
    C,H--100136453(+) atgatG/Tatgat 5 -- int10--------
    rs592746901,2
    C--100136453(+) ATGAT-/ATT   
      ATT
    /GA
    TGATG
    10 -- int1 cds10--------
    rs107604961,2
    C,A,H--100136462(+) ATGATT/GATTAT 5 -- int13Minor allele frequency- G:0.20NA CSA 5
    rs668275621,2
    C--130501437(+) TTTTTT/-CTTTT 7 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs1885108371,2
    --130513638(+) CTCACA/TGCAAG 7 -- ds50010--------
    rs1181315761,2
    F--130513643(+) AGCAAG/AGCTTT 7 -- ds50011Minor allele frequency- A:0.01NA 120
    rs1127737771,2
    F--130513757(+) TCTTGG/ATAAAT 7 -- ds50012Minor allele frequency- A:0.07CSA WA 120
    rs1450055121,2
    --130513867(+) TTCTAC/GCCCAG 7 -- ds50010--------
    rs1487339791,2
    C--130513878(+) GAGCCC/TGAGAG 7 -- ds50010--------

    HapMap Linkage Disequilibrium report for SH2D3C (130500596 - 130541048 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SH2D3C (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv893870CNV Loss21882294
    nsv466571CNV Loss19166990
    dgv8288n71CNV Loss21882294
    nsv893868CNV Loss21882294
    nsv893865CNV Loss21882294
    nsv466573CNV Loss19166990
    nsv471323CNV Loss18288195
    nsv893867CNV Loss21882294
    dgv8287n71CNV Loss21882294
    nsv466575CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SH2D3C
    DNA2.0 Custom Variant and Variant Library Synthesis for SH2D3C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604722    OMIM disorders: --

    15 diseases for SH2D3C:    
    About MalaCards
    western equine encephalitis    eastern equine encephalitis    venezuelan equine encephalitis    chikungunya
    estrogen resistance    encephalitis    gastroenteritis    severe acute respiratory syndrome
    cleft lip    diarrhea    lateral sclerosis    amyotrophic lateral sclerosis
    malaria    breast cancer    endotheliitis

    6 diseases from the University of Copenhagen DISEASES database for SH2D3C:
    Venezuelan equine encephalitis     Chikungunya     Severe acute respiratory syndrome     Gastroenteritis
    Eastern equine encephalitis     Diarrhea

    SH2D3C for disorders           About GeneDecksing

    Genetic Association Database (GAD): SH2D3C
    Human Genome Epidemiology (HuGE) Navigator: SH2D3C (1 document)

    Export disorders for SH2D3C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SH2D3C gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with SH2D3C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress- activated protein kinase signaling pathway. (PubMed id 10187783)1, 2, 3 Lu Y.... Stewart T.A. (J. Biol. Chem. 1999)
    2. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. (PubMed id 22081014)1, 2 Mace P.D.... Riedl S.J. (Nat. Struct. Mol. Biol. 2011)
    3. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PubMed id 20583170)1, 4 Letra A....Vieira A.R. (Am. J. Med. Genet. A 2010)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    8. Genetic variants associated with disordered eating. (PubMed id 23568457)1 Wade T.D....Martin N.G. (Int J Eat Disord 2013)
    9. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)1 Zhu J....Elledge S.J. (Nat. Biotechnol. 2013)
    10. AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology. (PubMed id 17427198)1 Near R.I....Lerner A. (J. Cell. Physiol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10044 HGNC: 16884 AceView: SH2D3C Ensembl:ENSG00000095370 euGenes: HUgn10044
    ECgene: SH2D3C H-InvDB: SH2D3C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SH2D3C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SH2D3C gene:
    Search GeneIP for patents involving SH2D3C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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