Aliases for SH2D3C Gene
External Ids for SH2D3C Gene
Previous GeneCards Identifiers for SH2D3C Gene
This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
GeneCards Summary for SH2D3C Gene
SH2D3C (SH2 Domain Containing 3C) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and SH3/SH2 adaptor activity. An important paralog of this gene is BCAR3.
UniProtKB/Swiss-Prot for SH2D3C Gene
Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration (By similarity).