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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SH2D3C Gene

protein-coding GIFtS: 55
GCID: GC09M130501

SH2 domain containing 3C

(Previous name: SH2 domain-containing 3C )

Explore 15 diseases affiliated with
SH2D3C via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
SH2 Domain Containing 3C¹ ²		PRO34088²
NSP3¹ ² ³		SH2 Domain-Containing Protein 3C²
Novel SH2-Containing Protein 3² ³		SHEP1³
SH2 Domain-Containing 3C¹		SH2 Domain-Containing Eph Receptor-Binding Protein 1³
CHAT²

External Ids:	HGNC: 16884¹	Entrez Gene: 10044²	Ensembl: ENSG00000095370⁷	OMIM: 604722⁵	UniProtKB: Q8N5H7³

Export aliases for SH2D3C gene to outside databases

Previous GC identifers: GC09M121615 GC09M122147 GC09M123954 GC09M125876 GC09M127580 GC09M129540 GC09M100117

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SH2D3C:

This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded

protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which

allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript

variants encoding different isoforms have been found for this gene. (provided by RefSeq, Nov 2011)

UniProtKB/Swiss-Prot: SH2D3_HUMAN, Q8N5H7

Function: Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required

to induce membrane ruffling and promote EGF-dependent cell migration (By similarity)

Gene Wiki entry for SH2D3C

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SH2D3C gene promoter:
p53 p300 STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SH2D3C promoter sequence

Search SABiosciences Chromatin IP Primers for SH2D3C

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH2D3C

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11 Ensembl cytogenetic band: 9q34.11 HGNC cytogenetic band: 9q33.1-q33.3

SH2D3C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SH2D3C gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M130501: view genomic region (about GC identifiers)

Start:	130,500,596 bp from pter	End:	130,541,048 bp from pter
Size:	40,453 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SH2D3_HUMAN, Q8N5H7 (See protein sequence)

Recommended Name: SH2 domain-containing protein 3C

Size: 860 amino acids; 94411 Da

Subunit: Interacts with PTK2B. Interacts with NEDD9/HEF1 (By similarity). Interacts (via C-terminus) with BCAR1/CAS

Subcellular location: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Note=Associated

with the membrane when EGF-stimulated. Found at ruffling membranes (By similarity)

Sequence caution: Sequence=AAQ88456.1; Type=Erroneous initiation;

1 PDB 3D structure from and Proteopedia for SH2D3C:

3T6G (3D)

Secondary accessions: A8K5S8 E9PG48 Q5HYE5 Q5JU31 Q6UY42 Q8N6X3 Q9Y2X5

Alternative splicing: 6 isoforms: Q8N5H7-1 Q8N5H7-2 Q8N5H7-3 Q8N5H7-4 Q8N5H7-5 Q8N5H7-6 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SH2D3C: NX_Q8N5H7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N5H7

SH2D3C Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (7 alternative transcripts):

NP_001136003.1 NP_001136004.1 NP_001136005.1 NP_001136006.1 NP_001239263.1 NP_005480.2 NP_733745.1

ENSEMBL proteins:

ENSP00000362374 ENSP00000388536 ENSP00000317817 ENSP00000401641 ENSP00000413760

ENSP00000362373 ENSP00000362371 ENSP00000394632

Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SH2D3C

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005737	cytoplasm	IEA	--
GO:0016020	membrane	IEA	--

SH2D3C for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for SH2D3C

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SH2D3C for domains About GeneDecksing

3 InterPro domains/families:

IPR000980 SH2

IPR023578 Ras_GEF_dom

IPR001895 RasGRF_CDC25

Graphical View of Domain Structure for InterPro Entry Q8N5H7

ProtoNet protein and cluster: Q8N5H7

2 Blocks protein families:

IPB000980 SH2 domain signature

IPB001895 Guanine-nucleotide dissociation stimulator CDC25

UniProtKB/Swiss-Prot: SH2D3_HUMAN, Q8N5H7

Domain: The C-terminal Cdc25-homology/Ras-GEF domain adopts a closed conformation rendering it incapable of carrying

out canonical exchange factor function, this closed conformation is required for interaction with BCAR1

Similarity: Contains 1 Ras-GEF domain

Similarity: Contains 1 SH2 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SH2D3_HUMAN, Q8N5H7

Function: Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required

to induce membrane ruffling and promote EGF-dependent cell migration (By similarity)

miRNA Products:		OriGene 3'-UTR Clone (see all 6): SH2D3C Browse MicroRNA Expression Plasmids
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		8 QIAGEN miScript miRNA Assays for microRNAs that regulate SH2D3C:
		hsa-miR-561 hsa-miR-324-3p hsa-miR-128 hsa-miR-3681* hsa-miR-548t hsa-miR-342-5p hsa-miR-493* hsa-miR-548n

		SwitchGear 3'UTR luciferase reporter plasmid: SH2D3C 3' UTR sequence

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Gene Editing
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		Search LifeMap BioReagents cell lines for SH2D3C

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH2D3C

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005070	SH3/SH2 adaptor activity	TAS	10187783
GO:0005085	guanyl-nucleotide exchange factor activity	IEA	--

SH2D3C for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for SH2D3C:

Increased HPV18 LCR reporter a

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-out Sh2d3c^tm1.1Ebp for SH2D3C
9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Sh2d3c):

behavior/neurological	cellular	endocrine/exocrine gland	hematopoietic system	immune system
mortality/aging	nervous system	no phenotypic analysis	reproductive system

SH2D3C for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

EGFR1 Signaling Pathway

EGFR1 Signaling Pathway

1.00

1 BioSystems Pathway for SH2D3C

EGFR1 Signaling Pathway

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SH2D3C

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/9 Interacting proteins for SH2D3C (Q8N5H7^{2, 3} ENSP00000317817⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EFS	O43281²^,³, ENSP00000216733⁴	MINT-66753 I2D: score=5 STRING: ENSP00000216733
SNCAIP	Q9Y6H5²^,³, ENSP00000261368⁴	MINT-64300 I2D: score=4 STRING: ENSP00000261368
BCAR1	P56945³, ENSP00000162330⁴	I2D: score=2 STRING: ENSP00000162330
NEDD9	Q14511³, ENSP00000368759⁴	I2D: score=2 STRING: ENSP00000368759
CARD11	Q9BXL7³, ENSP00000380150⁴	I2D: score=1 STRING: ENSP00000380150

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007254	JNK cascade	TAS	10187783
GO:0007264	small GTPase mediated signal transduction	IEA	--

SH2D3C for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SH2D3C
Search CenterWatch for drugs/clinical trials and news about SH2D3C / SH2D3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SH2D3C gene (7 alternative transcripts):

NM_001142531.1 NM_001142532.1 NM_001142533.1 NM_001142534.1 NM_001252334.1 NM_005489.3 NM_170600.2

Unigene Cluster for SH2D3C:

SH2 domain containing 3C

Hs.306412 [show with all ESTs]

Unigene Representative Sequence: NM_170600

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000373277(uc004bsa.3) ENST00000473535 ENST00000420366(uc004bry.3)

ENST00000314830(uc004bsd.1 uc004bsc.3) ENST00000468969 ENST00000484160

ENST00000471939 ENST00000440630 ENST00000464239 ENST00000488685 ENST00000414380

ENST00000373276(uc004bsb.3) ENST00000373274(uc010mxo.3) ENST00000429553(uc004brz.4 uc011mak.2)

miRNA Products:		OriGene 3'-UTR Clone (see all 6): SH2D3C Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SH2D3C
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate SH2D3C:
		hsa-miR-561 hsa-miR-324-3p hsa-miR-128 hsa-miR-3681* hsa-miR-548t hsa-miR-342-5p hsa-miR-493* hsa-miR-548n

		SwitchGear 3'UTR luciferase reporter plasmid: SH2D3C 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SH2D3C

Additional cDNA sequence:

AF124251.1 AJ420431.1 AK000861.1 AK056068.1 AK096983.1 AK128287.1 AK291393.1 AK292041.1

AK292718.1 AK294386.1 AK311510.1 AY358089.1 AY358440.1 BC027962.1 BC032365.1 BX647905.1

16 DOTS entries:

DT.40306903 DT.95089397 DT.100787946 DT.412045 DT.95089374 DT.101982497 DT.101956083 DT.121174286

DT.97799195 DT.121174248 DT.121174254 DT.121174275 DT.92421650 DT.92421651 DT.97839395 DT.91960749

24/109 AceView cDNA sequences (see all 109):

BX647905 AI472242 CA389145 BU738118 BG757892 AI814519 AI676011 BM542752

AI239541 AW264171 BI821749 BQ693987 CB269008 BI833455 AI799905 BI489573

AK096983 BC027962 AA234642 AI658523 AK056068 BI821487 BM457354 BX475433

GeneLoc Exon Structure

5/19 Alternative Splicing Database (ASD) splice patterns (SP) for SH2D3C (see all 19) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	·	5c	·	5d	^	6a	·	6b	^	7	^	8	^	9a	·	9b	^	10a	·	10b	·	10c	·	10d	^	11	^	12	^
SP1:									-		-										-		-		-		-		-		-		-		-		-				-		-		-		-		-		-
SP2:																													-		-		-		-		-				-		-		-		-		-		-
SP3:																																																	-		-
SP4:									-		-				-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP5:																																					-				-		-		-		-		-		-

ExUns:	13a	·	13b	·	13c	^	14a	·	14b	·	14c	·	14d	·	14e	·	14f	·	14g	^	15a	·	15b	^	16a	·	16b	^	17	^	18	^	19	^	20	^	21a	·	21b
SP1:	-				-														-
SP2:	-				-														-
SP3:	-				-														-
SP4:	-		-		-		-		-		-		-		-		-		-		-		-		-
SP5:	-				-														-

ECgene alternative splicing isoforms for SH2D3C

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SH2D3C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTATTTCTTT

About this image

SH2D3C expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 7 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SH2D3C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SH2D3C

SOURCE GeneReport for Unigene cluster: Hs.306412

UniProtKB/Swiss-Prot: SH2D3_HUMAN, Q8N5H7

Tissue specificity: Ubiquitously expressed

SABiosciences Custom PCR Arrays for SH2D3C

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SH2D3C Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SH2D3C
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SH2D3C

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH2D3C

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SH2D3C gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SH2D3C¹	SH2 domain containing 3C	71.86(n) 71.58(a)		417225 XM_415508.3 XP_415508.3
lizard (Anolis carolinensis)	Reptilia	SH2D3C⁶	--	71(a)	1 ↔ 1	GL344184.1(4769-14976)
African clawed frog (Xenopus laevis)	Amphibia	sh2d3c-prov²	SH2 domain containing 3C	74.88(n)		BC041733.1
zebrafish (Danio rerio)	Actinopterygii	zgc56490²	similar to SH2 domain containing 3C	72.3(n)		394051 BC049321.1
fruit fly (Drosophila melanogaster)	Insecta	CG9098^{1 , 3}	SH3/SH2 adaptor protein³ CG9098¹	35(a)³ 46.86(n)¹ 37.4(a)¹		26B3³ 33840¹ NM_135135.3¹ NP_608979.2¹

ENSEMBL Gene Tree for SH2D3C (if available)
TreeFam Gene Tree for SH2D3C (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SH2D3C gene

SH2D3A² BCAR3²

3 SIMAP similar genes for SH2D3C using alignment to 4 protein entries: SH2D3_HUMAN (see all proteins):

SHC3 BCAR3 SH2D3A

SH2D3C for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112773777^1,2		--	100116997(+)	`TCTTGG/ATAAAT`	7	--	ds500¹		2		CSA WA	120
rs41276214^1,2		--	100117479(+)	`GTGTCC/TTTGGG`	7	--	ut3¹		0	--	--	--	--
rs66827562^1,2	C	--	100117973(+)	`TTTTTT/-CTTTT`	7	--	int¹		1		NA	2
rs7852090^1,2	C,F,A,H,	--	100118773(+)	`GAAGCT/CGAGGT`	7	--	int¹		24		NS EA NA CSA WA	2766
rs74816856^1,2		--	100118856(+)	`TCTTTC/TGGATT`	7	--	int¹		1		EA	120
rs112124887^1,2	C,	--	100119001(+)	`TCACTG/ATCCAT`	7	--	int¹		2		CSA WA	120
rs112979211^1,2		--	100120128(+)	`TGGCTC/TACTGC`	7	--	int¹		1		CSA	2
rs112877223^1,2	F,	--	100120343(+)	`ACGGCA/GCCCGG`	7	--	int¹		3		CSA WA NA	242
rs35357299^1,2	C,F,	--	100120347(+)	`CACCCG/AGCCTA`	7	--	int¹		4		NA	126
rs79929089^1,2	C,	--	100121997(+)	`AAATGT/CCCAGA`	7	--	int¹		3		CSA WA NA	241

HapMap Linkage Disequilibrium report for SH2D3C (130500596 - 130541048 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SH2D3C: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SH2D3C for disorders           About GeneDecksing

OMIM gene information: 604722    OMIM disorders: --

15 diseases for SH2D3C:    About MalaCards

western equine encephalitis eastern equine encephalitis venezuelan equine encephalitis cleft lip/palate

cleft lip severe acute respiratory syndrome amyotrophic lateral sclerosis lateral sclerosis

encephalitis estrogen resistance chikungunya gastroenteritis

diarrhea breast cancer hepatitis

6 diseases from the University of Copenhagen DISEASES database for SH2D3C:

Venezuelan equine encephalitis Chikungunya Severe acute respiratory syndrome Gastroenteritis

Eastern equine encephalitis Diarrhea

Human Genome Epidemiology (HuGE) Navigator: SH2D3C (1 document)

Export disorders for SH2D3C gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SH2D3C gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with SH2D3C)

Utopia: connect your pdf to the dynamic
world of online information

NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress- activated protein kinase signaling pathway. (PubMed id 10187783)^{1, 2, 3} Lu Y.... Stewart T.A. (1999)
NSP-Cas protein structures reveal a promiscuous inter action module in cell signaling. (PubMed id 22081014)^{1, 2} Mace P.D....Riedl S.J. (2011)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PubMed id 20583170)¹ Letra A....Vieira A.R. (2010)
AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology. (PubMed id 17427198)¹ Near R.I....Lerner A. (2007)
Large-scale identification of human genes implicated in epidermal barrier function. (PubMed id 17562024)¹ Toulza E.... Guerrin M. (2007)
Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling. (PubMed id 17270363)¹ Vervoort V.S....Pasquale E.B. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10044	HGNC: 16884	AceView: SH2D3C	Ensembl:ENSG00000095370	euGenes: HUgn10044
ECgene: SH2D3C	H-InvDB: SH2D3C

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SH2D3C	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SH2D3C gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SH2D3C gene:
Search GeneIP for patents involving SH2D3C

GeneCards and IP:
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