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Aliases for SH2D3C Gene

Aliases for SH2D3C Gene

  • SH2 Domain Containing 3C 2 3
  • NSP3 3 4 6
  • SH2 Domain-Containing Eph Receptor-Binding Protein 1 3 4
  • Novel SH2-Containing Protein 3 3 4
  • SHEP1 3 4
  • SH2 Domain-Containing Protein 3C 3
  • SH2 Domain-Containing 3C 2
  • PRO34088 3
  • ChAT 3

External Ids for SH2D3C Gene

Summaries for SH2D3C Gene

Entrez Gene Summary for SH2D3C Gene

  • This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for SH2D3C Gene

SH2D3C (SH2 Domain Containing 3C) is a Protein Coding gene. Diseases associated with SH2D3C include eastern equine encephalitis and venezuelan equine encephalitis. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and SH3/SH2 adaptor activity. An important paralog of this gene is SH2D3A.

UniProtKB/Swiss-Prot for SH2D3C Gene

  • Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration (By similarity).

Gene Wiki entry for SH2D3C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH2D3C Gene

Genomics for SH2D3C Gene

Genomic Location for SH2D3C Gene

Start:
127,738,317 bp from pter
End:
127,778,769 bp from pter
Size:
40,453 bases
Orientation:
Minus strand

Genomic View for SH2D3C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SH2D3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH2D3C Gene

Regulatory Elements for SH2D3C Gene

Transcription factor binding sites by QIAGEN in the SH2D3C gene promoter:

Proteins for SH2D3C Gene

  • Protein details for SH2D3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5H7-SH2D3_HUMAN
    Recommended name:
    SH2 domain-containing protein 3C
    Protein Accession:
    Q8N5H7
    Secondary Accessions:
    • A8K5S8
    • E9PG48
    • Q5HYE5
    • Q5JU31
    • Q6UY42
    • Q8N6X3
    • Q9Y2X5

    Protein attributes for SH2D3C Gene

    Size:
    860 amino acids
    Molecular mass:
    94411 Da
    Quaternary structure:
    • Interacts with PTK2B. Interacts with NEDD9/HEF1 (By similarity). Interacts (via C-terminus) with BCAR1/CAS.
    SequenceCaution:
    • Sequence=AAQ88456.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SH2D3C Gene

    Alternative splice isoforms for SH2D3C Gene

neXtProt entry for SH2D3C Gene

Proteomics data for SH2D3C Gene at MOPED

Post-translational modifications for SH2D3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SH2D3C Gene

Domains for SH2D3C Gene

Gene Families for SH2D3C Gene

HGNC:
  • SH2D :SH2 domain containing

Graphical View of Domain Structure for InterPro Entry

Q8N5H7

UniProtKB/Swiss-Prot:

SH2D3_HUMAN
Domain:
  • The C-terminal Cdc25-homology/Ras-GEF domain adopts a closed conformation rendering it incapable of carrying out canonical exchange factor function, this closed conformation is required for interaction with BCAR1:
    • Q8N5H7
  • Contains 1 Ras-GEF domain.:
    • Q8N5H7
  • Contains 1 SH2 domain.:
    • Q8N5H7
genes like me logo Genes that share domains with SH2D3C: view

Function for SH2D3C Gene

Molecular function for SH2D3C Gene

UniProtKB/Swiss-Prot Function: Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration (By similarity).

Gene Ontology (GO) - Molecular Function for SH2D3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 10187783
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding IPI 24728074
genes like me logo Genes that share ontologies with SH2D3C: view
genes like me logo Genes that share phenotypes with SH2D3C: view

Animal Models for SH2D3C Gene

MGI Knock Outs for SH2D3C:

miRNA for SH2D3C Gene

miRTarBase miRNAs that target SH2D3C

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SH2D3C Gene

Localization for SH2D3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH2D3C Gene

Cytoplasm. Membrane; Peripheral membrane protein. Note=Associated with the membrane when EGF-stimulated. Found at ruffling membranes (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SH2D3C Gene COMPARTMENTS Subcellular localization image for SH2D3C gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SH2D3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SH2D3C: view

Pathways for SH2D3C Gene

genes like me logo Genes that share pathways with SH2D3C: view

Gene Ontology (GO) - Biological Process for SH2D3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007254 JNK cascade TAS 10187783
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0009967 positive regulation of signal transduction TAS 10187783
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with SH2D3C: view

Transcripts for SH2D3C Gene

Unigene Clusters for SH2D3C Gene

SH2 domain containing 3C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SH2D3C Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^
SP1: - - - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - -
SP4: - - - - - - - - - - - - - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - -
SP8: -
SP9: - - -
SP10: - - - -
SP11: - - - - - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - - - - -
SP14: - - - - -
SP15: - - -
SP16: -
SP17: -
SP18:
SP19: - - - - - - - - - - - - - - - -

ExUns: 13a · 13b · 13c ^ 14a · 14b · 14c · 14d · 14e · 14f · 14g ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - - - - - - - - - - -
SP5: - - -
SP6: -
SP7: - -
SP8: - -
SP9:
SP10:
SP11: -
SP12: - -
SP13: - -
SP14: -
SP15: - -
SP16: - -
SP17:
SP18:
SP19: - - - - - - - - - - -

Relevant External Links for SH2D3C Gene

GeneLoc Exon Structure for
SH2D3C
ECgene alternative splicing isoforms for
SH2D3C

Expression for SH2D3C Gene

mRNA expression in normal human tissues for SH2D3C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH2D3C Gene

This gene is overexpressed in Whole Blood (9.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SH2D3C Gene

SOURCE GeneReport for Unigene cluster for SH2D3C Gene Hs.306412

mRNA Expression by UniProt/SwissProt for SH2D3C Gene

Q8N5H7-SH2D3_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with SH2D3C: view

Orthologs for SH2D3C Gene

This gene was present in the common ancestor of animals.

Orthologs for SH2D3C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SH2D3C 35
  • 99.34 (n)
  • 99.77 (a)
SH2D3C 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SH2D3C 35
  • 88.99 (n)
  • 90.58 (a)
SH2D3C 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SH2D3C 35
  • 88.81 (n)
  • 90.44 (a)
SH2D3C 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sh2d3c 35
  • 85.5 (n)
  • 87.26 (a)
Sh2d3c 16
Sh2d3c 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SH2D3C 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SH2D3C 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sh2d3c 35
  • 85.32 (n)
  • 86.88 (a)
chicken
(Gallus gallus)
Aves SH2D3C 35
  • 71.42 (n)
  • 70.89 (a)
SH2D3C 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SH2D3C 36
  • 57 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia sh2d3c-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sh2d3c 35
  • 65.03 (n)
  • 66.83 (a)
zebrafish
(Danio rerio)
Actinopterygii sh2d3ca 35
  • 64.43 (n)
  • 62.14 (a)
sh2d3ca 36
  • 48 (a)
OneToMany
sh2d3cb 36
  • 48 (a)
OneToMany
zgc56490 35
fruit fly
(Drosophila melanogaster)
Insecta CG9098 36
  • 22 (a)
OneToMany
CG9098 37
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10354 36
  • 25 (a)
OneToMany
Species with no ortholog for SH2D3C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SH2D3C Gene

ENSEMBL:
Gene Tree for SH2D3C (if available)
TreeFam:
Gene Tree for SH2D3C (if available)

Paralogs for SH2D3C Gene

Paralogs for SH2D3C Gene

Selected SIMAP similar genes for SH2D3C Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SH2D3C: view

Variants for SH2D3C Gene

Sequence variations from dbSNP and Humsavar for SH2D3C Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs514024 -- 127,741,791(+) ACCTG(A/G)GCCAT reference, synonymous-codon
rs516073 -- 127,743,899(+) GGGGC(A/G)GAGAG intron-variant
rs539472 -- 127,741,333(+) cctcc(C/G/T)tggtt intron-variant
rs565073 -- 127,748,394(-) GGCTC(C/T)GTCTC intron-variant
rs869386 -- 127,770,157(+) TAGCC(A/G)GGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH2D3C Gene

Variant ID Type Subtype PubMed ID
nsv893859 CNV Loss 21882294
nsv893860 CNV Gain 21882294
nsv893865 CNV Loss 21882294
nsv893867 CNV Loss 21882294
nsv893868 CNV Loss 21882294
dgv8287n71 CNV Loss 21882294
nsv466571 CNV Loss 19166990
nsv893870 CNV Loss 21882294
nsv471323 CNV Loss 18288195
nsv466573 CNV Loss 19166990
nsv825094 CNV Gain 20364138
dgv8288n71 CNV Loss 21882294
nsv466575 CNV Loss 19166990
nsv893874 CNV Loss 21882294

Relevant External Links for SH2D3C Gene

HapMap Linkage Disequilibrium report
SH2D3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH2D3C Gene

Disorders for SH2D3C Gene

Relevant External Links for SH2D3C

Genetic Association Database (GAD)
SH2D3C
Human Genome Epidemiology (HuGE) Navigator
SH2D3C
genes like me logo Genes that share disorders with SH2D3C: view

No data available for UniProtKB/Swiss-Prot for SH2D3C Gene

Publications for SH2D3C Gene

  1. NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress- activated protein kinase signaling pathway. (PMID: 10187783) Lu Y. … Stewart T.A. (J. Biol. Chem. 1999) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SH2D3C Gene

Sources for SH2D3C Gene

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