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Aliases for SH2D3A Gene

Aliases for SH2D3A Gene

  • SH2 Domain Containing 3A 2 3
  • Novel SH2-Containing Protein 1 3 4
  • SH2 Domain-Containing 3A 2 3
  • NSP1 3 4
  • SH2 Domain-Containing Protein 3A 3

External Ids for SH2D3A Gene

Previous GeneCards Identifiers for SH2D3A Gene

  • GC19M006846
  • GC19M006692
  • GC19M006703
  • GC19M006514

Summaries for SH2D3A Gene

GeneCards Summary for SH2D3A Gene

SH2D3A (SH2 Domain Containing 3A) is a Protein Coding gene. Diseases associated with SH2D3A include venezuelan equine encephalitis. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and SH3/SH2 adaptor activity. An important paralog of this gene is BCAR3.

UniProtKB/Swiss-Prot for SH2D3A Gene

  • May play a role in JNK activation

Gene Wiki entry for SH2D3A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH2D3A Gene

Genomics for SH2D3A Gene

Regulatory Elements for SH2D3A Gene

Transcription factor binding sites by QIAGEN in the SH2D3A gene promoter:

Genomic Location for SH2D3A Gene

6,752,160 bp from pter
6,767,588 bp from pter
15,429 bases
Minus strand

Genomic View for SH2D3A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SH2D3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH2D3A Gene

Proteins for SH2D3A Gene

  • Protein details for SH2D3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH2 domain-containing protein 3A
    Protein Accession:
    Secondary Accessions:
    • A8K9R6
    • B4DRS7
    • Q9Y2X4

    Protein attributes for SH2D3A Gene

    576 amino acids
    Molecular mass:
    63093 Da
    Quaternary structure:
    • Interacts with BCAR1.

    Alternative splice isoforms for SH2D3A Gene


neXtProt entry for SH2D3A Gene

Proteomics data for SH2D3A Gene at MOPED

Post-translational modifications for SH2D3A Gene

Other Protein References for SH2D3A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SH2D3A Gene

Domains for SH2D3A Gene

Gene Families for SH2D3A Gene

Protein Domains for SH2D3A Gene

Suggested Antigen Peptide Sequences for SH2D3A Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SH2 domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with SH2D3A: view

Function for SH2D3A Gene

Molecular function for SH2D3A Gene

UniProtKB/Swiss-Prot Function:
May play a role in JNK activation

Gene Ontology (GO) - Molecular Function for SH2D3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 10187783
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding IPI 24658140
genes like me logo Genes that share ontologies with SH2D3A: view

Phenotypes for SH2D3A Gene

GenomeRNAi human phenotypes for SH2D3A:
genes like me logo Genes that share phenotypes with SH2D3A: view

Animal Model Products

CRISPR Products

miRNA for SH2D3A Gene

miRTarBase miRNAs that target SH2D3A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SH2D3A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SH2D3A Gene

Localization for SH2D3A Gene

Subcellular locations from

Jensen Localization Image for SH2D3A Gene COMPARTMENTS Subcellular localization image for SH2D3A gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SH2D3A Gene

Pathways for SH2D3A Gene

SuperPathways for SH2D3A Gene

No Data Available

Gene Ontology (GO) - Biological Process for SH2D3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007254 JNK cascade TAS 10187783
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0009967 positive regulation of signal transduction TAS 10187783
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with SH2D3A: view

No data available for Pathways by source for SH2D3A Gene

Drugs for SH2D3A Gene

(2) Novoseek inferred chemical compound relationships for SH2D3A Gene

Compound -log(P) Hits PubMed IDs
enterotoxin 32.6 2
zinc 9.79 3
genes like me logo Genes that share compounds with SH2D3A: view

Transcripts for SH2D3A Gene

Unigene Clusters for SH2D3A Gene

SH2 domain containing 3A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SH2D3A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH2D3A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b ^ 12
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - -

Relevant External Links for SH2D3A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH2D3A Gene

mRNA expression in normal human tissues for SH2D3A Gene

mRNA differential expression in normal tissues according to GTEx for SH2D3A Gene

This gene is overexpressed in Esophagus - Mucosa (5.2) and Skin - Not Sun Exposed (Suprapubic) (4.1).

Protein differential expression in normal tissues for SH2D3A Gene

This gene is overexpressed in Stomach (29.7), Placenta (23.8), and Pancreas (13.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SH2D3A Gene

SOURCE GeneReport for Unigene cluster for SH2D3A Gene Hs.439645

mRNA Expression by UniProt/SwissProt for SH2D3A Gene

Tissue specificity: Weakly expressed in placenta, fetal kidney, fetal lung, adult pancreas, adult kidney and adult lung.
genes like me logo Genes that share expressions with SH2D3A: view

Expression partners for SH2D3A Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SH2D3A Gene

Orthologs for SH2D3A Gene

This gene was present in the common ancestor of animals.

Orthologs for SH2D3A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SH2D3A 35
  • 84.03 (n)
  • 82.93 (a)
SH2D3A 36
  • 82 (a)
(Canis familiaris)
Mammalia SH2D3A 35
  • 83.54 (n)
  • 81.04 (a)
SH2D3A 36
  • 80 (a)
(Pan troglodytes)
Mammalia SH2D3A 35
  • 99.25 (n)
  • 99.48 (a)
SH2D3A 36
  • 99 (a)
(Monodelphis domestica)
Mammalia SH2D3A 36
  • 46 (a)
(Danio rerio)
Actinopterygii CABZ01115881.1 36
  • 23 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9098 36
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10354 36
  • 22 (a)
Species with no ortholog for SH2D3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SH2D3A Gene

Gene Tree for SH2D3A (if available)
Gene Tree for SH2D3A (if available)

Paralogs for SH2D3A Gene

Paralogs for SH2D3A Gene

(3) SIMAP similar genes for SH2D3A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SH2D3A: view

Variants for SH2D3A Gene

Sequence variations from dbSNP and Humsavar for SH2D3A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs692638 -- 6,762,729(-) CCAGT(C/T)TGGGC intron-variant
rs1054060 -- 6,752,423(-) ATGTG(A/G)CCTGC utr-variant-3-prime
rs2305807 -- 6,754,177(-) CTCAG(A/G)TCTCT intron-variant, reference, missense, downstream-variant-500B
rs3786684 -- 6,766,456(-) TCTCT(A/G)TGCTT intron-variant
rs3810226 -- 6,767,732(+) TTGTA(C/T)ATAGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SH2D3A Gene

Variant ID Type Subtype PubMed ID
nsv470120 CNV Loss 18288195
dgv3703n71 CNV Loss 21882294
dgv14e196 CNV Duplication 17116639
nsv910940 CNV Loss 21882294
nsv519827 CNV Loss 19592680
nsv910941 CNV Loss 21882294
nsv910942 CNV Loss 21882294
nsv519561 CNV Loss 19592680
esv2661790 CNV Deletion 23128226

Relevant External Links for SH2D3A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH2D3A Gene

Disorders for SH2D3A Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SH2D3A Gene in MalaCards »

(1) Disease for SH2D3A Gene

genes like me logo Genes that share disorders with SH2D3A: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for SH2D3A Gene

Publications for SH2D3A Gene

  1. NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress- activated protein kinase signaling pathway. (PMID: 10187783) Lu Y. … Stewart T.A. (J. Biol. Chem. 1999) 2 3 4 23
  2. AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology. (PMID: 17427198) Near R.I. … Lerner A. (J. Cell. Physiol. 2007) 3 23
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SH2D3A Gene

Sources for SH2D3A Gene

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