SH2D3A Gene
protein-coding GIFtS: 51
GCID: GC19M006752
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|
SH2 domain containing 3A(Previous name: SH2 domain-containing 3A )
| |
Aliases
for SH2D3A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SH2 Domain Containing 3A1 2 | | NSP11 2 3 | | SH2 Domain-Containing 3A1 2 | | Novel SH2-Containing Protein 12 3 | | SH2 Domain-Containing Protein 3A2 |
Export aliases for SH2D3A gene to outside databasesPrevious GC identifers: GC19M006846 GC19M006692 GC19M006703 GC19M006514 |
Summaries
for SH2D3A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SH23A_HUMAN, Q9BRG2Function: May play a role in JNK activation
Gene Wiki entry for SH2D3A
|
Genomic Views
for SH2D3A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SH2D3A gene promoter:
AML1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for SH2D3A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH2D3A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3SH2D3A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M006752: view genomic region
(about GC identifiers)
Start:
|
6,752,171 bp from pter |
End:
|
6,767,523 bp from pter |
Size:
|
15,353 bases |
Orientation:
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minus strand |
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Proteins
for SH2D3A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SH23A_HUMAN, Q9BRG2 (See
protein sequence)Recommended Name: SH2 domain-containing protein 3A Size: 576 amino acids; 63093 Da
Subunit: Interacts with BCAR1
Secondary accessions: A8K9R6 Q9Y2X4Explore the universe of human proteins at neXtProt for SH2D3A: NX_Q9BRG2
Post-translational modifications:
Phosphorylated on tyrosine1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BRG2
SH2D3A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005481.2
ENSEMBL proteins: ENSP00000245908 ENSP00000393303
Human Recombinant Protein Products for SH2D3A:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
SH2D3A for ontologies About GeneDecksing
SH2D3A Antibody Products:
Assay Products for SH2D3A: |
Protein
Domains /
Families
for SH2D3A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SH2D3A for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BRG2ProtoNet protein and cluster: Q9BRG2 1 Blocks protein family: IPB000980 SH2 domain signature
UniProtKB/Swiss-Prot: SH23A_HUMAN, Q9BRG2Similarity: Contains 1 SH2 domain |
Function
for SH2D3A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SH23A_HUMAN, Q9BRG2Function: May play a role in JNK activation Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005070 | SH3/SH2 adaptor activity |
TAS | 10187783 | | GO:0005085 | guanyl-nucleotide exchange factor activity |
IEA | -- |
SH2D3A for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for SH2D3A:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SH2D3A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SH2D3A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for SH2D3A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH2D3A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH2D3A |
|
Pathways & Interactions
for SH2D3A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SH2D3A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/7 Interacting proteins for SH2D3A (Q9BRG22, 3 ENSP000002459084) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
SH2D3A for ontologies About GeneDecksing
|
Drugs & Compounds
for SH2D3A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SH2D3A for compounds About GeneDecksing
 Browse Tocris compounds for SH2D3A
2 Novoseek chemical compound relationships for SH2D3A gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| enterotoxin |
32.6 |
2 |
16789013 (1), 10963341 (1) |
| zinc |
9.79 |
3 |
10470258 (2), 10567650 (1) |
Search CenterWatch for drugs/clinical trials and news about SH2D3A / SH23A
|
Transcripts
for SH2D3A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SH2D3A gene: NM_005490.2 Unigene Cluster for SH2D3A: SH2 domain containing 3A Hs.439645 [show with all ESTs]Unigene Representative Sequence: AK0243682 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000245908(uc002mft.3) ENST00000437152(uc010xjg.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SH2D3A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SH2D3A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SH2D3A (NM_005490) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SH2D3A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH2D3A |
Additional cDNA sequence: AF124249.1 AK024368.1 AK225386.1 AK290293.1 AK292781.1 AK299406.1 AK310659.1 AY358406.1 BC006281.2 4 DOTS entries: DT.409914 DT.91744745 DT.121470609 DT.95235342 24/80 AceView cDNA sequences (see all 80): BQ685085 AA877909 BI335052 NM_005490 BM982677 AI452584 BI907677 BI964046 CB163127 AI564559 BU539713 AU099227 CB305869 AA641471 BC006281 AA527381 AA577688 AF124249 AY358406 AI783815 BQ688088 CB158903 BM968679 AU140467
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SH2D3A (see all 6) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 |
|---|
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| SP1: | | | | | | | - | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SH2D3A
|
Expression
for SH2D3A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SH2D3A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SH2D3A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SH2D3A
SOURCE GeneReport for Unigene cluster: Hs.439645
UniProtKB/Swiss-Prot: SH23A_HUMAN, Q9BRG2Tissue specificity: Weakly expressed in placenta, fetal kidney, fetal lung, adult pancreas, adult kidney and adult lung
SABiosciences Custom PCR Arrays for SH2D3A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SH2D3A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SH2D3A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SH2D3A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SH2D3A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH2D3A |
Orthologs
for SH2D3A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SH2D3A gene from 2/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
CABZ01115881.16 |
-- |
24(a) |
1 ↔ 1 |
1(59799090-59812722) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG90986 |
-- |
16(a) |
1 → many |
2L(6007364-6012338) |
Species with no ortholog for SH2D3A
ENSEMBL Gene Tree for SH2D3A (if available)
TreeFam Gene Tree for SH2D3A (if available) |
Paralogs
for SH2D3A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SH2D3A gene
- SH2D3C2 BCAR32
2 SIMAP similar genes for SH2D3A using alignment to 3 protein entries: SH23A_HUMAN (see all proteins):BCAR3 SH2D3C
SH2D3A for paralogs About GeneDecksing
|
Genomic Variants
for SH2D3A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SH2D3A (6752171 - 6767523 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SH2D3A
3 CNVs: 5341 5340 5342 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SH2D3A |
|
Disorders
/ Diseases
for SH2D3A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SH2D3A for disorders About GeneDecksing
OMIM gene information: 604721
OMIM disorders: --
12  diseases for SH2D3A: About MalaCardsvenezuelan equine encephalitis severe acute respiratory syndrome viral encephalitis estrogen resistance
chikungunya encephalitis gastroenteritis diarrhea
vaccinia pneumonia breast cancer hepatitis
5 diseases from the University of Copenhagen DISEASES database for SH2D3A:Chikungunya Venezuelan equine encephalitis Gastroenteritis Severe acute respiratory syndrome
Diarrhea Export disorders for SH2D3A gene to outside databases
|
Publications
for SH2D3A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SH2D3A gene, integrated from 9 sources (see all 62):
(articles sorted by number of sources associating them with SH2D3A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress- activated protein kinase signaling pathway. (PubMed id 10187783)1, 2, 3, 9 Lu Y.... Stewart T.A. (1999)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology. (PubMed id 17427198)1, 9 Near R.I....Lerner A. (2007)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling. (PubMed id 17270363)1 Vervoort V.S....Pasquale E.B. (2007)
|
External Searches for SH2D3A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SH2D3A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SH2D3A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SH2D3A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SH2D3A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SH2D3A gene:
Search GeneIP for patents involving SH2D3A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SH2D3A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| |
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 | | | SH2D3A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH2D3A |
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