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Aliases for SH2D3A Gene

Aliases for SH2D3A Gene

  • SH2 Domain Containing 3A 2 3 5
  • Novel SH2-Containing Protein 1 3 4
  • SH2 Domain-Containing 3A 2 3
  • NSP1 3 4

External Ids for SH2D3A Gene

Previous GeneCards Identifiers for SH2D3A Gene

  • GC19M006846
  • GC19M006692
  • GC19M006703
  • GC19M006514

Summaries for SH2D3A Gene

GeneCards Summary for SH2D3A Gene

SH2D3A (SH2 Domain Containing 3A) is a Protein Coding gene. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and SH3/SH2 adaptor activity. An important paralog of this gene is SH2D3C.

UniProtKB/Swiss-Prot for SH2D3A Gene

  • May play a role in JNK activation.

Gene Wiki entry for SH2D3A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH2D3A Gene

Genomics for SH2D3A Gene

Regulatory Elements for SH2D3A Gene

Promoters for SH2D3A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SH2D3A on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SH2D3A gene promoter:

Genomic Location for SH2D3A Gene

Chromosome:
19
Start:
6,752,160 bp from pter
End:
6,767,588 bp from pter
Size:
15,429 bases
Orientation:
Minus strand

Genomic View for SH2D3A Gene

Genes around SH2D3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH2D3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH2D3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH2D3A Gene

Proteins for SH2D3A Gene

  • Protein details for SH2D3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRG2-SH23A_HUMAN
    Recommended name:
    SH2 domain-containing protein 3A
    Protein Accession:
    Q9BRG2
    Secondary Accessions:
    • A8K9R6
    • B4DRS7
    • Q9Y2X4

    Protein attributes for SH2D3A Gene

    Size:
    576 amino acids
    Molecular mass:
    63093 Da
    Quaternary structure:
    • Interacts with BCAR1.

    Alternative splice isoforms for SH2D3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SH2D3A Gene

Proteomics data for SH2D3A Gene at MOPED

Post-translational modifications for SH2D3A Gene

Other Protein References for SH2D3A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SH2D3A Gene

Domains & Families for SH2D3A Gene

Gene Families for SH2D3A Gene

Protein Domains for SH2D3A Gene

Suggested Antigen Peptide Sequences for SH2D3A Gene

Graphical View of Domain Structure for InterPro Entry

Q9BRG2

UniProtKB/Swiss-Prot:

SH23A_HUMAN :
  • Contains 1 SH2 domain.
Domain:
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with SH2D3A: view

Function for SH2D3A Gene

Molecular function for SH2D3A Gene

UniProtKB/Swiss-Prot Function:
May play a role in JNK activation.
genes like me logo Genes that share phenotypes with SH2D3A: view

Animal Model Products

CRISPR Products

miRNA for SH2D3A Gene

miRTarBase miRNAs that target SH2D3A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SH2D3A Gene

Localization for SH2D3A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SH2D3A Gene COMPARTMENTS Subcellular localization image for SH2D3A gene
Compartment Confidence
cytosol 3
nucleus 3
endosome 1
plasma membrane 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SH2D3A Gene

Pathways & Interactions for SH2D3A Gene

SuperPathways for SH2D3A Gene

No Data Available

Gene Ontology (GO) - Biological Process for SH2D3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with SH2D3A: view

No data available for Pathways by source and SIGNOR curated interactions for SH2D3A Gene

Drugs & Compounds for SH2D3A Gene

(1) Drugs for SH2D3A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SH2D3A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SH2D3A: view

Transcripts for SH2D3A Gene

Unigene Clusters for SH2D3A Gene

SH2 domain containing 3A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SH2D3A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b ^ 12
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - -
SP5:
SP6:

Relevant External Links for SH2D3A Gene

GeneLoc Exon Structure for
SH2D3A
ECgene alternative splicing isoforms for
SH2D3A

Expression for SH2D3A Gene

mRNA expression in normal human tissues for SH2D3A Gene

mRNA differential expression in normal tissues according to GTEx for SH2D3A Gene

This gene is overexpressed in Esophagus - Mucosa (x5.2) and Skin - Not Sun Exposed (Suprapubic) (x4.1).

Protein differential expression in normal tissues from HIPED for SH2D3A Gene

This gene is overexpressed in Stomach (29.7), Placenta (23.8), and Pancreas (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SH2D3A Gene



SOURCE GeneReport for Unigene cluster for SH2D3A Gene Hs.439645

mRNA Expression by UniProt/SwissProt for SH2D3A Gene

Q9BRG2-SH23A_HUMAN
Tissue specificity: Weakly expressed in placenta, fetal kidney, fetal lung, adult pancreas, adult kidney and adult lung.
genes like me logo Genes that share expression patterns with SH2D3A: view

Protein tissue co-expression partners for SH2D3A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SH2D3A Gene

Orthologs for SH2D3A Gene

This gene was present in the common ancestor of animals.

Orthologs for SH2D3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SH2D3A 35
  • 99.25 (n)
  • 99.48 (a)
SH2D3A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SH2D3A 36
  • 82 (a)
OneToOne
SH2D3A 35
  • 84.03 (n)
  • 82.93 (a)
dog
(Canis familiaris)
Mammalia SH2D3A 35
  • 83.54 (n)
  • 81.04 (a)
SH2D3A 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SH2D3A 36
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01115881.1 36
  • 23 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9098 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10354 36
  • 22 (a)
OneToMany
Species with no ortholog for SH2D3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SH2D3A Gene

ENSEMBL:
Gene Tree for SH2D3A (if available)
TreeFam:
Gene Tree for SH2D3A (if available)

Paralogs for SH2D3A Gene

Paralogs for SH2D3A Gene

(3) SIMAP similar genes for SH2D3A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SH2D3A: view

Variants for SH2D3A Gene

Sequence variations from dbSNP and Humsavar for SH2D3A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7258236 - 6,760,963(+) GCCAT(C/T)TTGCT intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime
VAR_035989 A breast cancer sample
rs12608960 - 6,755,144(+) AGGCA(C/T)CAGGC intron-variant, nc-transcript-variant, reference, missense
rs439718 -- 6,757,330(+) ttttt(A/T)aattt intron-variant
rs168129 -- 6,754,763(+) TGAAG(A/C)GTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH2D3A Gene

Variant ID Type Subtype PubMed ID
nsv470120 CNV Loss 18288195
dgv3703n71 CNV Loss 21882294
dgv14e196 CNV Duplication 17116639
nsv910940 CNV Loss 21882294
nsv519827 CNV Loss 19592680
nsv910941 CNV Loss 21882294
nsv910942 CNV Loss 21882294
nsv519561 CNV Loss 19592680
esv2661790 CNV Deletion 23128226

Variation tolerance for SH2D3A Gene

Residual Variation Intolerance Score: 96.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.47; 85.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH2D3A Gene

HapMap Linkage Disequilibrium report
SH2D3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH2D3A Gene

Disorders for SH2D3A Gene

Relevant External Links for SH2D3A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SH2D3A

No disorders were found for SH2D3A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH2D3A Gene

Publications for SH2D3A Gene

  1. NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress- activated protein kinase signaling pathway. (PMID: 10187783) Lu Y. … Stewart T.A. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology. (PMID: 17427198) Near R.I. … Lerner A. (J. Cell. Physiol. 2007) 3 23
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. In silico prediction of physical protein interactions and characterization of interactome orphans. (PMID: 25402006) Kotlyar M. … Jurisica I. (Nat. Methods 2015) 3
  5. The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. (PMID: 24658140) Petschnigg J. … Stagljar I. (Nat. Methods 2014) 3

Products for SH2D3A Gene

Sources for SH2D3A Gene

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