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Aliases for SH2D3A Gene

Aliases for SH2D3A Gene

  • SH2 Domain Containing 3A 2 3 5
  • Novel SH2-Containing Protein 1 3 4
  • NSP1 3 4
  • SH2 Domain-Containing Protein 3A 3
  • SH2 Domain-Containing 3A 2

External Ids for SH2D3A Gene

Previous GeneCards Identifiers for SH2D3A Gene

  • GC19M006846
  • GC19M006692
  • GC19M006703
  • GC19M006514

Summaries for SH2D3A Gene

GeneCards Summary for SH2D3A Gene

SH2D3A (SH2 Domain Containing 3A) is a Protein Coding gene. Diseases associated with SH2D3A include Severe Acute Respiratory Syndrome. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and SH3/SH2 adaptor activity. An important paralog of this gene is BCAR3.

UniProtKB/Swiss-Prot for SH2D3A Gene

  • May play a role in JNK activation.

Gene Wiki entry for SH2D3A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH2D3A Gene

Genomics for SH2D3A Gene

Regulatory Elements for SH2D3A Gene

Enhancers for SH2D3A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F006765 1.1 ENCODE 55.6 +0.3 306 4.5 HDGF ATF1 PKNOX1 ARID4B SIN3A ETS1 ZNF121 GTF3C2 GLIS2 ZNF207 SH2D3A FLJ25758 MBD3L5 MBD3L3 LOC390877 XAB2 RPL21P129 ZNF557 ACSBG2 ENSG00000267571
GH19F006751 1.4 Ensembl ENCODE 31.8 +14.7 14712 3.3 HDGF PKNOX1 MLX CREB3L1 SIN3A ARID4B DMAP1 YY1 SLC30A9 ZNF766 SH2D3A ENSG00000269680 PIR50354
GH19F006771 1.2 FANTOM5 ENCODE 36.9 -5.4 -5419 2.3 HDAC1 TBP ATF1 PKNOX1 ZBTB40 EGR1 ZNF366 ZNF143 ETV6 KDM4B SH2D3A DENND1C VAV1 ZNF557 ADGRE1 GPR108 GC19P006821
GH19F006085 1.6 FANTOM5 Ensembl ENCODE 9.7 +679.7 679720 3.9 HDGF PKNOX1 ARID4B FEZF1 GLI4 ZNF2 GTF3C2 ZNF766 FOS JUNB ZNF557 VMAC ENSG00000267571 SNRPEP4 SAFB RFX2 ACSBG2 SH2D3A FUT5 SAFB2
GH19F006270 1.5 FANTOM5 ENCODE 9.7 +492.2 492236 10.7 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF557 SNRPEP4 SAFB ENSG00000267571 VMAC ACSBG2 LOC390877 MBD3L3 MBD3L5 FLJ25758
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SH2D3A on UCSC Golden Path with GeneCards custom track

Promoters for SH2D3A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000342738 -12 1601 HDGF ATF1 PKNOX1 ARID4B SIN3A ZNF121 GTF3C2 GLIS2 ZNF143 ZNF207

Transcription factor binding sites by QIAGEN in the SH2D3A gene promoter:

Genomic Location for SH2D3A Gene

6,752,160 bp from pter
6,767,588 bp from pter
15,429 bases
Minus strand

Genomic View for SH2D3A Gene

Genes around SH2D3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH2D3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH2D3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH2D3A Gene

Proteins for SH2D3A Gene

  • Protein details for SH2D3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH2 domain-containing protein 3A
    Protein Accession:
    Secondary Accessions:
    • A8K9R6
    • B4DRS7
    • Q9Y2X4

    Protein attributes for SH2D3A Gene

    576 amino acids
    Molecular mass:
    63093 Da
    Quaternary structure:
    • Interacts with BCAR1.

    Alternative splice isoforms for SH2D3A Gene


neXtProt entry for SH2D3A Gene

Post-translational modifications for SH2D3A Gene

No data available for DME Specific Peptides for SH2D3A Gene

Domains & Families for SH2D3A Gene

Gene Families for SH2D3A Gene

Protein Domains for SH2D3A Gene

Suggested Antigen Peptide Sequences for SH2D3A Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SH2 domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with SH2D3A: view

Function for SH2D3A Gene

Molecular function for SH2D3A Gene

UniProtKB/Swiss-Prot Function:
May play a role in JNK activation.

Gene Ontology (GO) - Molecular Function for SH2D3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 10187783
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding IPI 24658140
genes like me logo Genes that share ontologies with SH2D3A: view
genes like me logo Genes that share phenotypes with SH2D3A: view

Animal Model Products

miRNA for SH2D3A Gene

miRTarBase miRNAs that target SH2D3A

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SH2D3A Gene

Localization for SH2D3A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH2D3A gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 1
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for SH2D3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with SH2D3A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SH2D3A Gene

Pathways & Interactions for SH2D3A Gene

SuperPathways for SH2D3A Gene

No Data Available

Gene Ontology (GO) - Biological Process for SH2D3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007254 JNK cascade TAS 10187783
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0009967 positive regulation of signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with SH2D3A: view

No data available for Pathways by source and SIGNOR curated interactions for SH2D3A Gene

Drugs & Compounds for SH2D3A Gene

(1) Drugs for SH2D3A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SH2D3A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SH2D3A: view

Transcripts for SH2D3A Gene

Unigene Clusters for SH2D3A Gene

SH2 domain containing 3A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH2D3A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b ^ 12
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - -

Relevant External Links for SH2D3A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SH2D3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SH2D3A Gene

mRNA differential expression in normal tissues according to GTEx for SH2D3A Gene

This gene is overexpressed in Esophagus - Mucosa (x5.2) and Skin - Not Sun Exposed (Suprapubic) (x4.1).

Protein differential expression in normal tissues from HIPED for SH2D3A Gene

This gene is overexpressed in Stomach (29.7), Placenta (23.8), and Pancreas (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SH2D3A Gene

Protein tissue co-expression partners for SH2D3A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SH2D3A Gene:


SOURCE GeneReport for Unigene cluster for SH2D3A Gene:


mRNA Expression by UniProt/SwissProt for SH2D3A Gene:

Tissue specificity: Weakly expressed in placenta, fetal kidney, fetal lung, adult pancreas, adult kidney and adult lung.
genes like me logo Genes that share expression patterns with SH2D3A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SH2D3A Gene

Orthologs for SH2D3A Gene

This gene was present in the common ancestor of animals.

Orthologs for SH2D3A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SH2D3A 34 35
  • 99.25 (n)
(Bos Taurus)
Mammalia SH2D3A 34 35
  • 84.03 (n)
(Canis familiaris)
Mammalia SH2D3A 34 35
  • 83.54 (n)
(Monodelphis domestica)
Mammalia SH2D3A 35
  • 46 (a)
(Danio rerio)
Actinopterygii CABZ01115881.1 35
  • 23 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9098 35
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10354 35
  • 22 (a)
Species where no ortholog for SH2D3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SH2D3A Gene

Gene Tree for SH2D3A (if available)
Gene Tree for SH2D3A (if available)

Paralogs for SH2D3A Gene

Paralogs for SH2D3A Gene

(3) SIMAP similar genes for SH2D3A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SH2D3A: view

Variants for SH2D3A Gene

Sequence variations from dbSNP and Humsavar for SH2D3A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_035989 A breast cancer sample
rs10401463 -- 6,758,606(+) ccTTC(C/G/T)CTTCC intron-variant
rs10403119 -- 6,764,812(+) gtgat(C/T)ctccc intron-variant
rs10404295 -- 6,755,109(+) GGGCA(C/T)CAGCT intron-variant, reference, missense
rs10406774 -- 6,758,155(+) atttt(A/T)tttta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH2D3A Gene

Variant ID Type Subtype PubMed ID
nsv519827 CNV loss 19592680
nsv519561 CNV loss 19592680
nsv470120 CNV loss 18288195
nsv1055253 CNV gain 25217958
esv3643564 CNV loss 21293372
esv2661790 CNV deletion 23128226
dgv14e196 CNV duplication 17116639

Variation tolerance for SH2D3A Gene

Residual Variation Intolerance Score: 96.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.47; 85.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH2D3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH2D3A Gene

Disorders for SH2D3A Gene

MalaCards: The human disease database

(1) MalaCards diseases for SH2D3A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
severe acute respiratory syndrome
  • sars
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SH2D3A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SH2D3A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SH2D3A Gene

Publications for SH2D3A Gene

  1. NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress- activated protein kinase signaling pathway. (PMID: 10187783) Lu Y. … Stewart T.A. (J. Biol. Chem. 1999) 2 3 4 22 64
  2. AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology. (PMID: 17427198) Near R.I. … Lerner A. (J. Cell. Physiol. 2007) 3 22 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for SH2D3A Gene

Sources for SH2D3A Gene

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