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SH2D2A Gene

protein-coding   GIFtS: 58
GCID: GC01M156776

SH2 Domain Containing 2A

(Previous name: SH2 domain protein 2A)
  See SH2D2A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SH2 Domain Containing 2A1 2     VEGF Receptor-Associated Protein2 3
TSAD2 3 5     T Cell Specific Adpater Protein TSAd1
SH2 Domain Protein 2A1 2     F27712
T Cell Specific Adapter Protein TSAd1 2     SH2 Domain-Containing Protein 2A2
T Lymphocyte Specific Adaptor Protein1 2     TSAd3
SCAP2 3     SH2 Domain-Containing Adapter Protein3
VRAP2 3     T Cell-Specific Adapter Protein3

External Ids:    HGNC: 108211   Entrez Gene: 90472   Ensembl: ENSG000000278697   OMIM: 6045145   UniProtKB: Q9NP313   

Export aliases for SH2D2A gene to outside databases

Previous GC identifers: GC01M154645 GC01M152541 GC01M153553 GC01M153992 GC01M153589 GC01M155042 GC01M128134


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SH2D2A Gene:
This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse
is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream
signaling. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Mar 2010)

GeneCards Summary for SH2D2A Gene:
SH2D2A (SH2 domain containing 2A) is a protein-coding gene. Diseases associated with SH2D2A include chronic inflammatory demyelinating polyradiculoneuropathy, and polyradiculoneuropathy. GO annotations related to this gene include SH3/SH2 adaptor activity and SH3 domain binding. An important paralog of this gene is SH2D7.

UniProtKB/Swiss-Prot: SH22A_HUMAN, Q9NP31
Function: Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role
in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and
pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with
effector proteins important to endothelial cell survival and proliferation

Gene Wiki entry for SH2D2A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SH2D2A gene promoter:
         GR   c-Fos   AP-1   p53   ATF-2   CREB   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSH2D2A promoter sequence
   Search Chromatin IP Primers for SH2D2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SH2D2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q21

SH2D2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SH2D2A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M156776:  view genomic region     (about GC identifiers)

Start:
156,776,035 bp from pter      End:
156,786,654 bp from pter
Size:
10,620 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SH22A_HUMAN, Q9NP31 (See protein sequence)
Recommended Name: SH2 domain-containing protein 2A  
Size: 389 amino acids; 42934 Da
Subunit: Interacts with KDR. Interacts with TXK and ITK (By similarity)
Sequence caution: Sequence=AAC99298.1; Type=Erroneous initiation;
Secondary accessions: O43817 Q5UBZ1 Q5VZS4 Q5VZS5 Q9UPA7
Alternative splicing: 4 isoforms:  Q9NP31-1   Q9NP31-2   Q9NP31-3   Q9NP31-4   

Explore the universe of human proteins at neXtProt for SH2D2A: NX_Q9NP31

Explore proteomics data for SH2D2A at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SH2D2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001154913.1  NP_001154914.1  NP_001154915.1  NP_001154916.1  NP_003966.2  

    ENSEMBL proteins: 
     ENSP00000357181   ENSP00000357182   ENSP00000376123  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    1 InterPro protein domain:
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q9NP31

    ProtoNet protein and cluster: Q9NP31

    1 Blocks protein domain: IPB000980 SH2 domain signature

    UniProtKB/Swiss-Prot: SH22A_HUMAN, Q9NP31
    Similarity: Contains 1 SH2 domain


    Find genes that share domains with SH2D2A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SH22A_HUMAN, Q9NP31
    Function: Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role
    in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and
    pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with
    effector proteins important to endothelial cell survival and proliferation
    Induction: Rapidly induced after activation of T-cells. However, the gene continues to be expressed in long-term
    cultures of activated T-cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity TAS9468509
    GO:0005515protein binding IPI10553045
    GO:0017124SH3 domain binding IEA--
         
    Find genes that share ontologies with SH2D2A           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sh2d2a):
     hematopoietic system  immune system 

    Find genes that share phenotypes with SH2D2A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sh2d2atm1Jbs for SH2D2A

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    Selected qRT-PCR Assays for microRNAs that regulate SH2D2A (see all 23):
    hsa-miR-495 hsa-miR-15a hsa-miR-575 hsa-miR-103a hsa-miR-424 hsa-miR-508-5p hsa-miR-195 hsa-miR-24
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SH22A_HUMAN, Q9NP31: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with SH2D2A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SH2D2A About    
    See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    VEGF signaling pathway0.39
    VEGF - VEGF R2 Signaling Pathways0.35
    2Apoptotic Pathways in Synovial Fibroblasts
    ERK5 Signaling0.61
    3Signaling events mediated by VEGFR1 and VEGFR2
    Signaling events mediated by VEGFR1 and VEGFR20.37
    4ErbB1 downstream signaling
    ErbB1 downstream signaling


    Find genes that share SuperPaths with SH2D2A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for SH2D2A
        VEGF - VEGF R2 Signaling Pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SH2D2A
        ERK5 Signaling

    1 GeneGo (Thomson Reuters) Pathway for SH2D2A
        Development VEGF signaling via VEGFR2 - generic cascades

    2 BioSystems Pathways for SH2D2A
        Signaling events mediated by VEGFR1 and VEGFR2
    ErbB1 downstream signaling



    1 Kegg Pathway  (Kegg details for SH2D2A):
        VEGF signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including SH2D2A: 
              VEGF Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SH2D2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for SH2D2A (Q9NP311, 2, 3 ENSP000003571824) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LCKP062391, 2, 3, ENSP000003378254EBI-490630,EBI-1348 MINT-7303133 MINT-7303194 MINT-7135547 MINT-7135623 MINT-7303144 MINT-7135538 MINT-7135634 MINT-7135612 MINT-7135817 MINT-7135583 MINT-7303166 I2D: score=6 STRING: ENSP00000337825
    ERBB2P046261, 2, 3, ENSP000002695714EBI-490630,EBI-641062 MINT-74721 MINT-74722 I2D: score=2 STRING: ENSP00000269571
    VCPP550722, 3, ENSP000003517774MINT-8027255 I2D: score=1 STRING: ENSP00000351777
    EGFRP005332, 3, ENSP000002754934MINT-74720 I2D: score=1 STRING: ENSP00000275493
    MAP3K2Q9Y2U53, ENSP000003434634I2D: score=3 STRING: ENSP00000343463
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0007165signal transduction TAS9468509
    GO:0008283cell proliferation IEA--
    GO:0009967positive regulation of signal transduction TAS9468509
    GO:0030154cell differentiation IEA--

    Find genes that share ontologies with SH2D2A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SH2D2A (SH22A)

    4 Novoseek inferred chemical compound relationships for SH2D2A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphotyrosine 39.1 2 9468509 (1)
    tyrosine 38.7 10 16835467 (1), 11700021 (1), 18641339 (1), 20305788 (1) (see all 6)
    phosphatidylinositol 30.5 2 10692392 (1), 11831708 (1)
    vegf 10.7 5 10692392 (3), 16835467 (1)



    Find genes that share compounds with SH2D2A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SH2D2A gene (5 alternative transcripts): 
    NM_001161441.1  NM_001161442.1  NM_001161443.1  NM_001161444.1  NM_003975.3  

    Unigene Cluster for SH2D2A:

    SH2 domain containing 2A
    Hs.103527  [show with all ESTs]
    Unigene Representative Sequence: NM_001161441
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368198 ENST00000368199(uc001fqc.1 uc001fqd.2 uc001fqe.2 uc010phs.1)
    ENST00000468744 ENST00000486350 ENST00000495306 ENST00000392306(uc009wsh.2)

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    Additional mRNA sequence: 

    AF051325.1 AF097744.1 AJ000553.1 AK222737.1 AK313706.1 AY763098.1 AY763099.1 AY763100.1 
    BC012107.1 

    10 DOTS entries:

    DT.310833  DT.100735791  DT.97844674  DT.121451171  DT.121451149  DT.121451141  DT.92026976  DT.95169178 
    DT.121451156  DT.92062400 

    Selected AceView cDNA sequences (see all 73):

    AF097744 BI518824 NM_003975 BG389115 AA719598 BM918444 AW630148 BQ012931 
    BC012107 AA613070 BM817769 BE253512 BM919385 BQ052734 AA720013 BM919011 
    BM805057 BI907564 AF051325 BI193381 BF511238 BG489152 BQ073131 BM685926 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SH2D2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTCCCCTT
    SH2D2A Expression
    About this image

    SH2D2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SH2D2A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.103527

    UniProtKB/Swiss-Prot: SH22A_HUMAN, Q9NP31
    Tissue specificity: Expression limited to tissues of the immune system and, in particular, activated T-cells.
    Expressed in peripheral blood leukocytes, thymus and spleen. Much lower expression or undetectable, in brain,
    placenta, skeletal muscle, prostate, testis, ovary, small intestine, and colon. Expressed at low levels in
    unstimulated T-cells, but not expressed in normal resting or activated B-cells. According to PubMed:10692392,
    expression is not restricted to activated T-cells, but strongly expressed in blood cell lineages, the endothelium
    and other cell and tissue types, such as heart, lung, and liver

        Pathway & Disease-focused RT2 Profiler PCR Array including SH2D2A: 
              VEGF Signaling in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SH2D2A gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sh2d2a1 , 5 SH2 domain protein 2A1, 5 76.8(n)1
    70.82(a)1
      3 (38.78 cM)5
    273711  NM_021309.31  NP_067284.11 
     878467555 
    chicken
    (Gallus gallus)
    Aves SH2D2A6
    SH2 domain containing 2A
    34(a)
    1 ↔ 1
    25(439414-441198)
    lizard
    (Anolis carolinensis)
    Reptilia SH2D2A6
    SH2 domain containing 2A
    29(a)
    1 ↔ 1
    GL344373.1(24654-35527)
    zebrafish
    (Danio rerio)
    Actinopterygii SH2D2A6
    SH2 domain containing 2A
    16(a)
    1 ↔ 1
    19(11704374-11720327) ENSDARG00000089983
    worm
    (Caenorhabditis elegans)
    Secernentea F13B12.66
    Protein F13B12.6 (F13B12.6) mRNA, complete cds
    9(a)
    1 → many
    IV(10414072-10417881) WBGene00008733


    ENSEMBL Gene Tree for SH2D2A (if available)
    TreeFam Gene Tree for SH2D2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SH2D2A gene
    SH2D72  SH2D4A2  SH2D4B2  

    Find genes that share paralogs with SH2D2A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SH2D2A (see all 175)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1820274801,2
    --156780598(+) GTGAGC/TCACTG 5 -- int10--------
    rs1850387681,2
    --156780609(+) CGCCCC/GGCCAT 5 -- int10--------
    rs1893025381,2
    --156780670(+) GTGGGA/CTGGTT 5 -- int10--------
    rs1812067011,2
    --156780733(+) TGCTGC/TCCCCA 5 -- int10--------
    rs1173024271,2
    F--156780815(+) CCATCG/TGGAGG 5 -- int11Minor allele frequency- T:0.02EA 120
    rs46612211,2
    C,F,H--156780852(+) AAAGAA/GTTCTT 5 -- int16Minor allele frequency- G:0.10NS EA WA NA 658
    rs744216261,2
    C,F--156780873(+) TAACCC/TCCTCC 5 -- int11Minor allele frequency- T:0.06WA 118
    rs743625301,2
    C,F--156780973(+) TCCTCC/TCTCTT 5 -- int11Minor allele frequency- T:0.04WA 118
    rs1426397941,2
    --156781141(+) GCAGAC/GCAATC 5 -- int10--------
    rs741187661,2
    C,F--156781313(+) CCCTAC/TGCCCT 5 -- int13Minor allele frequency- T:0.04WA CSA 122

    HapMap Linkage Disequilibrium report for SH2D2A (156776035 - 156786654 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SH2D2A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831659CNV Loss17160897
    nsv831648CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SH2D2A
    DNA2.0 Custom Variant and Variant Library Synthesis for SH2D2A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604514    OMIM disorders: --

    3 diseases for SH2D2A:    
    About MalaCards
    chronic inflammatory demyelinating polyradiculoneuropathy    polyradiculoneuropathy    juvenile rheumatoid arthritis

    1 disease from the University of Copenhagen DISEASES database for SH2D2A:
    Chronic inflammatory demyelinating polyradiculoneuropathy

    Find genes that share disorders with SH2D2A           About GenesLikeMe

    3 Novoseek inferred disease relationships for SH2D2A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    multiple sclerosis 31.3 5 18554728 (2), 11528519 (1), 15129233 (1)
    neovascularization 27.7 2 16835467 (1), 10692392 (1)
    genetic susceptibility 23.6 2 15129233 (2)

    Genetic Association Database (GAD): SH2D2A
    Human Genome Epidemiology (HuGE) Navigator: SH2D2A (8 documents)

    Export disorders for SH2D2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SH2D2A gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with SH2D2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites. (PubMed id 9468509)1, 2, 3, 9 Spurkland A.... Aasheim H.-C. (J. Biol. Chem. 1998)
    2. The SH2D2A gene encoding the T-cell-specific adapter protein (TSAd) is localized centromeric to the CD1 gene cluster on human Chromosome 1. (PubMed id 10752626)1, 2, 9 Dai K.Z.... Spurkland A. (Immunogenetics 2000)
    3. Genetic association between juvenile rheumatoid arthritis and polymorphism in the SH2D2A gene. (PubMed id 15129233)1, 4, 9 Smerdel A....Spurkland A. (Genes Immun. 2004)
    4. VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor. (PubMed id 10692392)1, 2, 9 Wu L.-W.... Donner D.B. (J. Biol. Chem. 2000)
    5. The SH2D2A gene and susceptibility to multiple sclerosis. (PubMed id 18554728)1, 4, 9 Lorentzen A.R....Harbo H.F. (J. Neuroimmunol. 2008)
    6. The T cell regulator gene SH2D2A contributes to the genetic susceptibility of multiple sclerosis. (PubMed id 11528519)1, 4, 9 Dai K.Z....Spurkland A. (Genes Immun. 2001)
    7. Susceptibility to chronic inflammatory demyelinating polyradiculoneuropathy is associated to polymorphic GA repeat in the SH2D2A gene. (PubMed id 18533279)1, 4, 9 Notturno F....Uncini A. (J. Neuroimmunol. 2008)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9047 HGNC: 10821 AceView: SH2D2A Ensembl:ENSG00000027869 euGenes: HUgn9047
    ECgene: SH2D2A Kegg: 9047 H-InvDB: SH2D2A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SH2D2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SH2D2A gene:
    Search GeneIP for patents involving SH2D2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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