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Aliases for SH2D2A Gene

Aliases for SH2D2A Gene

  • SH2 Domain Containing 2A 2 3
  • TSAD 3 4 6
  • T Lymphocyte Specific Adaptor Protein 2 3
  • T Cell Specific Adapter Protein TSAd 2 3
  • VEGF Receptor-Associated Protein 3 4
  • SH2 Domain Protein 2A 2 3
  • SCAP 3 4
  • VRAP 3 4
  • SH2 Domain-Containing Adapter Protein 4
  • T Cell Specific Adpater Protein TSAd 2
  • SH2 Domain-Containing Protein 2A 3
  • T Cell-Specific Adapter Protein 4
  • F2771 3

External Ids for SH2D2A Gene

Summaries for SH2D2A Gene

Entrez Gene Summary for SH2D2A Gene

  • This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

GeneCards Summary for SH2D2A Gene

SH2D2A (SH2 Domain Containing 2A) is a Protein Coding gene. Diseases associated with SH2D2A include chronic inflammatory demyelinating polyradiculoneuropathy and polyradiculoneuropathy. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Regulation of Cholesterol Biosynthesis by SREBP (SREBF). GO annotations related to this gene include SH3 domain binding and SH3/SH2 adaptor activity. An important paralog of this gene is SH2D4B.

UniProtKB/Swiss-Prot for SH2D2A Gene

  • Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation

Gene Wiki entry for SH2D2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH2D2A Gene

Genomics for SH2D2A Gene

Genomic Location for SH2D2A Gene

Start:
156,806,243 bp from pter
End:
156,816,862 bp from pter
Size:
10,620 bases
Orientation:
Minus strand

Genomic View for SH2D2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SH2D2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH2D2A Gene

Regulatory Elements for SH2D2A Gene

Proteins for SH2D2A Gene

  • Protein details for SH2D2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP31-SH22A_HUMAN
    Recommended name:
    SH2 domain-containing protein 2A
    Protein Accession:
    Q9NP31
    Secondary Accessions:
    • O43817
    • Q5UBZ1
    • Q5VZS4
    • Q5VZS5
    • Q9UPA7

    Protein attributes for SH2D2A Gene

    Size:
    389 amino acids
    Molecular mass:
    42934 Da
    Quaternary structure:
    • Interacts with KDR. Interacts with TXK and ITK (By similarity).
    SequenceCaution:
    • Sequence=AAC99298.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SH2D2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SH2D2A Gene

Proteomics data for SH2D2A Gene at MOPED

Post-translational modifications for SH2D2A Gene

Other Protein References for SH2D2A Gene

No data available for DME Specific Peptides for SH2D2A Gene

Domains for SH2D2A Gene

Gene Families for SH2D2A Gene

HGNC:
  • SH2D :SH2 domain containing

Protein Domains for SH2D2A Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NP31

UniProtKB/Swiss-Prot:

SH22A_HUMAN
Domain:
  • Contains 1 SH2 domain.:
    • Q9NP31
genes like me logo Genes that share domains with SH2D2A: view

Function for SH2D2A Gene

Molecular function for SH2D2A Gene

UniProtKB/Swiss-Prot Function: Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation
UniProtKB/Swiss-Prot Induction: Rapidly induced after activation of T-cells. However, the gene continues to be expressed in long-term cultures of activated T-cells

Gene Ontology (GO) - Molecular Function for SH2D2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 9468509
GO:0005515 protein binding IPI 10553045
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with SH2D2A: view

Phenotypes for SH2D2A Gene

genes like me logo Genes that share phenotypes with SH2D2A: view

Animal Models for SH2D2A Gene

MGI Knock Outs for SH2D2A:

miRNA for SH2D2A Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SH2D2A Gene

Localization for SH2D2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH2D2A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SH2D2A Gene COMPARTMENTS Subcellular localization image for SH2D2A gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SH2D2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9468509
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SH2D2A: view

Pathways for SH2D2A Gene

genes like me logo Genes that share pathways with SH2D2A: view

Pathways by source for SH2D2A Gene

Gene Ontology (GO) - Biological Process for SH2D2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0007165 signal transduction TAS 9468509
GO:0008283 cell proliferation IEA --
GO:0009967 positive regulation of signal transduction TAS 9468509
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with SH2D2A: view

Compounds for SH2D2A Gene

(4) Novoseek inferred chemical compound relationships for SH2D2A Gene

Compound -log(P) Hits PubMed IDs
phosphotyrosine 39.1 1
tyrosine 38.7 6
phosphatidylinositol 30.5 2
vegf 10.7 4
genes like me logo Genes that share compounds with SH2D2A: view

Transcripts for SH2D2A Gene

Unigene Clusters for SH2D2A Gene

SH2 domain containing 2A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SH2D2A Gene

No ASD Table

Relevant External Links for SH2D2A Gene

GeneLoc Exon Structure for
SH2D2A
ECgene alternative splicing isoforms for
SH2D2A

Expression for SH2D2A Gene

mRNA expression in normal human tissues for SH2D2A Gene

mRNA differential expression in normal tissues according to GTEx for SH2D2A Gene

This gene is overexpressed in Whole Blood (25.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SH2D2A Gene

SOURCE GeneReport for Unigene cluster for SH2D2A Gene Hs.103527

mRNA Expression by UniProt/SwissProt for SH2D2A Gene

Q9NP31-SH22A_HUMAN
Tissue specificity: Expression limited to tissues of the immune system and, in particular, activated T-cells. Expressed in peripheral blood leukocytes, thymus and spleen. Much lower expression or undetectable, in brain, placenta, skeletal muscle, prostate, testis, ovary, small intestine, and colon. Expressed at low levels in unstimulated T-cells, but not expressed in normal resting or activated B-cells. According to PubMed:10692392, expression is not restricted to activated T-cells, but strongly expressed in blood cell lineages, the endothelium and other cell and tissue types, such as heart, lung, and liver
genes like me logo Genes that share expressions with SH2D2A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SH2D2A Gene

Orthologs for SH2D2A Gene

This gene was present in the common ancestor of animals.

Orthologs for SH2D2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SH2D2A 35
  • 99.49 (n)
  • 98.97 (a)
SH2D2A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SH2D2A 35
  • 83.25 (n)
  • 79.38 (a)
SH2D2A 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SH2D2A 35
  • 82.95 (n)
  • 77.12 (a)
SH2D2A 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sh2d2a 35
  • 76.8 (n)
  • 70.82 (a)
Sh2d2a 16
Sh2d2a 36
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SH2D2A 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SH2D2A 36
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sh2d2a 35
  • 74.42 (n)
  • 68.9 (a)
chicken
(Gallus gallus)
Aves SH2D2A 36
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SH2D2A 36
  • 29 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii SH2D2A 36
  • 16 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F13B12.6 36
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 7 (a)
OneToMany
Species with no ortholog for SH2D2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SH2D2A Gene

ENSEMBL:
Gene Tree for SH2D2A (if available)
TreeFam:
Gene Tree for SH2D2A (if available)

Paralogs for SH2D2A Gene

Paralogs for SH2D2A Gene

genes like me logo Genes that share paralogs with SH2D2A: view

Variants for SH2D2A Gene

Sequence variations from dbSNP and Humsavar for SH2D2A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs877097 -- 156,808,330(+) GTTTG(G/T)AGGGC intron-variant
rs909200 -- 156,808,319(-) AGCTC(A/G)GTCCC intron-variant
rs909201 -- 156,808,115(-) ggagt(C/G)gagtg intron-variant
rs928391 -- 156,806,925(-) AGCAG(A/G)AAAAA intron-variant, downstream-variant-500B
rs943555 -- 156,812,344(-) ggggg(C/G)ccctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH2D2A Gene

Variant ID Type Subtype PubMed ID
nsv831648 CNV Loss 17160897
nsv831659 CNV Loss 17160897

Relevant External Links for SH2D2A Gene

HapMap Linkage Disequilibrium report
SH2D2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH2D2A Gene

Disorders for SH2D2A Gene

(1) University of Copenhagen DISEASES for SH2D2A Gene

(3) Novoseek inferred disease relationships for SH2D2A Gene

Disease -log(P) Hits PubMed IDs
multiple sclerosis 31.3 4
neovascularization 27.7 2
genetic susceptibility 23.6 2

Relevant External Links for SH2D2A

Genetic Association Database (GAD)
SH2D2A
Human Genome Epidemiology (HuGE) Navigator
SH2D2A
genes like me logo Genes that share disorders with SH2D2A: view

No data available for UniProtKB/Swiss-Prot for SH2D2A Gene

Publications for SH2D2A Gene

  1. Molecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites. (PMID: 9468509) Spurkland A. … Aasheim H.-C. (J. Biol. Chem. 1998) 2 3 4 23
  2. VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor. (PMID: 10692392) Wu L.-W. … Donner D.B. (J. Biol. Chem. 2000) 3 4 23
  3. The SH2D2A gene encoding the T-cell-specific adapter protein (TSAd) is localized centromeric to the CD1 gene cluster on human Chromosome 1. (PMID: 10752626) Dai K.Z. … Spurkland A. (Immunogenetics 2000) 3 4 23
  4. The T cell regulator gene SH2D2A contributes to the genetic susceptibility of multiple sclerosis. (PMID: 11528519) Dai K.Z. … Spurkland A. (Genes Immun. 2001) 3 23 48
  5. Genetic association between juvenile rheumatoid arthritis and polymorphism in the SH2D2A gene. (PMID: 15129233) Smerdel A. … Spurkland A. (Genes Immun. 2004) 3 23 48

Products for SH2D2A Gene

Sources for SH2D2A Gene

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