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Aliases for SH2D2A Gene

Aliases for SH2D2A Gene

  • SH2 Domain Containing 2A 2 3 5
  • T Lymphocyte Specific Adaptor Protein 2 3
  • T Cell Specific Adapter Protein TSAd 2 3
  • VEGF Receptor-Associated Protein 3 4
  • SH2 Domain Protein 2A 2 3
  • SCAP 3 4
  • TSAD 3 4
  • VRAP 3 4
  • SH2 Domain-Containing Adapter Protein 4
  • T Cell Specific Adpater Protein TSAd 2
  • SH2 Domain-Containing Protein 2A 3
  • T Cell-Specific Adapter Protein 4
  • F2771 3

External Ids for SH2D2A Gene

Previous GeneCards Identifiers for SH2D2A Gene

  • GC01M154645
  • GC01M152541
  • GC01M153553
  • GC01M153992
  • GC01M153589
  • GC01M155042
  • GC01M128134

Summaries for SH2D2A Gene

Entrez Gene Summary for SH2D2A Gene

  • This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

GeneCards Summary for SH2D2A Gene

SH2D2A (SH2 Domain Containing 2A) is a Protein Coding gene. Among its related pathways are Development VEGF signaling via VEGFR2 - generic cascades and Immune response Fc epsilon RI pathway. GO annotations related to this gene include SH3 domain binding and SH3/SH2 adaptor activity. An important paralog of this gene is SH2D7.

UniProtKB/Swiss-Prot for SH2D2A Gene

  • Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation.

Gene Wiki entry for SH2D2A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH2D2A Gene

Genomics for SH2D2A Gene

Regulatory Elements for SH2D2A Gene

Enhancers for SH2D2A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G156812 1.6 Ensembl ENCODE dbSUPER 7.3 +1.1 1086 5.7 PKNOX1 MLX CREB3L1 AGO1 WRNIP1 ARID4B SIN3A DMAP1 SLC30A9 ZNF766 HDGF SH2D2A RRNAD1 NTRK1
GH01G156811 0.9 FANTOM5 dbSUPER 10.8 +4.7 4714 0.3 SMARCA5 SCRT1 ZMYM3 ZNF623 JUND HDAC2 SCRT2 ZNF580 FOS KDM1A SH2D2A ETV3L NTRK1 MEF2D GC01P156814 HDGF
GH01G156836 1.1 FANTOM5 ENCODE 6.7 -19.4 -19372 0.2 PKNOX1 TBL1XR1 BACH1 FEZF1 EBF1 RELA EED ZNF143 ETV6 RELB NTRK1 INSRR PEAR1 LRRC71 SH2D2A TSACC GC01M156858
GH01G156456 1.8 FANTOM5 ENCODE dbSUPER 1.6 +359.5 359486 2.7 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 KIAA0907 RRNAD1 ENSG00000271267 LOC246784 ARHGEF2 C1orf61 MIR9-1 SSR2 NAXE GPATCH4
GH01G156853 0.7 ENCODE 0.3 -35.6 -35612 0.1 L3MBTL2 NFIA NFIB REST NR2F2 ZNF579 FOSL1 NFIC HNF4A HNRNPL PEAR1 LRRC71 ENSG00000223356 HDGF MRPL24 MIR765 ARHGEF11 PRCC C1orf61 MIR9-1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SH2D2A on UCSC Golden Path with GeneCards custom track

Genomic Location for SH2D2A Gene

Chromosome:
1
Start:
156,806,243 bp from pter
End:
156,816,862 bp from pter
Size:
10,620 bases
Orientation:
Minus strand

Genomic View for SH2D2A Gene

Genes around SH2D2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH2D2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH2D2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH2D2A Gene

Proteins for SH2D2A Gene

  • Protein details for SH2D2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP31-SH22A_HUMAN
    Recommended name:
    SH2 domain-containing protein 2A
    Protein Accession:
    Q9NP31
    Secondary Accessions:
    • O43817
    • Q5UBZ1
    • Q5VZS4
    • Q5VZS5
    • Q9UPA7

    Protein attributes for SH2D2A Gene

    Size:
    389 amino acids
    Molecular mass:
    42934 Da
    Quaternary structure:
    • Interacts with KDR. Interacts with TXK and ITK (By similarity).
    SequenceCaution:
    • Sequence=AAC99298.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SH2D2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SH2D2A Gene

Post-translational modifications for SH2D2A Gene

No data available for DME Specific Peptides for SH2D2A Gene

Domains & Families for SH2D2A Gene

Gene Families for SH2D2A Gene

Protein Domains for SH2D2A Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SH2D2A: view

No data available for UniProtKB/Swiss-Prot for SH2D2A Gene

Function for SH2D2A Gene

Molecular function for SH2D2A Gene

UniProtKB/Swiss-Prot Function:
Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation.
UniProtKB/Swiss-Prot Induction:
Rapidly induced after activation of T-cells. However, the gene continues to be expressed in long-term cultures of activated T-cells.

Gene Ontology (GO) - Molecular Function for SH2D2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 9468509
GO:0005515 protein binding IPI 10553045
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with SH2D2A: view
genes like me logo Genes that share phenotypes with SH2D2A: view

Animal Models for SH2D2A Gene

MGI Knock Outs for SH2D2A:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SH2D2A Gene

Localization for SH2D2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH2D2A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH2D2A gene
Compartment Confidence
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for SH2D2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9468509
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SH2D2A: view

Pathways & Interactions for SH2D2A Gene

genes like me logo Genes that share pathways with SH2D2A: view

Pathways by source for SH2D2A Gene

1 GeneGo (Thomson Reuters) pathway for SH2D2A Gene
1 Qiagen pathway for SH2D2A Gene

Gene Ontology (GO) - Biological Process for SH2D2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0007165 signal transduction TAS 9468509
GO:0007275 multicellular organism development IEA --
GO:0008283 cell proliferation IEA --
GO:0009967 positive regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with SH2D2A: view

No data available for SIGNOR curated interactions for SH2D2A Gene

Drugs & Compounds for SH2D2A Gene

(1) Drugs for SH2D2A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for SH2D2A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SH2D2A: view

Transcripts for SH2D2A Gene

Unigene Clusters for SH2D2A Gene

SH2 domain containing 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH2D2A Gene

No ASD Table

Relevant External Links for SH2D2A Gene

GeneLoc Exon Structure for
SH2D2A
ECgene alternative splicing isoforms for
SH2D2A

Expression for SH2D2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SH2D2A Gene

mRNA differential expression in normal tissues according to GTEx for SH2D2A Gene

This gene is overexpressed in Whole Blood (x25.2).

Protein differential expression in normal tissues from HIPED for SH2D2A Gene

This gene is overexpressed in NK cells (20.1), Peripheral blood mononuclear cells (15.9), CD8 Tcells (14.9), Pancreatic juice (8.0), and Tlymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SH2D2A Gene



Protein tissue co-expression partners for SH2D2A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SH2D2A Gene:

SH2D2A

SOURCE GeneReport for Unigene cluster for SH2D2A Gene:

Hs.103527

mRNA Expression by UniProt/SwissProt for SH2D2A Gene:

Q9NP31-SH22A_HUMAN
Tissue specificity: Expression limited to tissues of the immune system and, in particular, activated T-cells. Expressed in peripheral blood leukocytes, thymus and spleen. Much lower expression or undetectable, in brain, placenta, skeletal muscle, prostate, testis, ovary, small intestine, and colon. Expressed at low levels in unstimulated T-cells, but not expressed in normal resting or activated B-cells. According to PubMed:10692392, expression is not restricted to activated T-cells, but strongly expressed in blood cell lineages, the endothelium and other cell and tissue types, such as heart, lung, and liver.

Evidence on tissue expression from TISSUES for SH2D2A Gene

  • Blood(4.5)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with SH2D2A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SH2D2A Gene

Orthologs for SH2D2A Gene

This gene was present in the common ancestor of animals.

Orthologs for SH2D2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SH2D2A 34 35
  • 99.49 (n)
cow
(Bos Taurus)
Mammalia SH2D2A 34 35
  • 83.25 (n)
dog
(Canis familiaris)
Mammalia SH2D2A 34 35
  • 82.95 (n)
mouse
(Mus musculus)
Mammalia Sh2d2a 34 16 35
  • 76.8 (n)
rat
(Rattus norvegicus)
Mammalia Sh2d2a 34
  • 74.42 (n)
oppossum
(Monodelphis domestica)
Mammalia SH2D2A 35
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SH2D2A 35
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves SH2D2A 35
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SH2D2A 35
  • 29 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii SH2D2A 35
  • 16 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F13B12.6 35
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 7 (a)
OneToMany
Species where no ortholog for SH2D2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SH2D2A Gene

ENSEMBL:
Gene Tree for SH2D2A (if available)
TreeFam:
Gene Tree for SH2D2A (if available)

Paralogs for SH2D2A Gene

Paralogs for SH2D2A Gene

genes like me logo Genes that share paralogs with SH2D2A: view

Variants for SH2D2A Gene

Sequence variations from dbSNP and Humsavar for SH2D2A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000046183 -- 156,807,746(+) GAGGT(G/T)GCAGG intron-variant
rs1000092368 -- 156,806,824(+) CCGCA(C/T)AGTGA intron-variant, downstream-variant-500B
rs1000144306 -- 156,807,028(+) TTGCC(A/C)TCCTT intron-variant, downstream-variant-500B
rs1000441554 -- 156,806,560(+) GTTGG(G/T)GGTCA downstream-variant-500B, utr-variant-3-prime
rs1000548061 -- 156,817,918(+) GATTA(A/C)AGGCG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SH2D2A Gene

Variant ID Type Subtype PubMed ID
esv3587642 CNV loss 21293372
nsv831648 CNV loss 17160897
nsv831659 CNV loss 17160897

Variation tolerance for SH2D2A Gene

Residual Variation Intolerance Score: 60.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 30.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SH2D2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SH2D2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH2D2A Gene

Disorders for SH2D2A Gene

Relevant External Links for SH2D2A

Genetic Association Database (GAD)
SH2D2A
Human Genome Epidemiology (HuGE) Navigator
SH2D2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SH2D2A

No disorders were found for SH2D2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH2D2A Gene

Publications for SH2D2A Gene

  1. Molecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites. (PMID: 9468509) Spurkland A. … Aasheim H.-C. (J. Biol. Chem. 1998) 2 3 4 22 64
  2. Susceptibility to chronic inflammatory demyelinating polyradiculoneuropathy is associated to polymorphic GA repeat in the SH2D2A gene. (PMID: 18533279) Notturno F. … Uncini A. (J. Neuroimmunol. 2008) 3 22 46 64
  3. The SH2D2A gene and susceptibility to multiple sclerosis. (PMID: 18554728) Lorentzen A.R. … Harbo H.F. (J. Neuroimmunol. 2008) 3 22 46 64
  4. Genetic association between juvenile rheumatoid arthritis and polymorphism in the SH2D2A gene. (PMID: 15129233) Smerdel A. … Spurkland A. (Genes Immun. 2004) 3 22 46 64
  5. The T cell regulator gene SH2D2A contributes to the genetic susceptibility of multiple sclerosis. (PMID: 11528519) Dai K.Z. … Spurkland A. (Genes Immun. 2001) 3 22 46 64

Products for SH2D2A Gene

Sources for SH2D2A Gene

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