SH2D1B Gene
protein-coding GIFtS: 54
GCID: GC01M162366
|
|
SH2 domain containing 1B
| |
Aliases
for SH2D1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SH2 Domain Containing 1B1 2 | | EAT21 2 3 5 | | EAT-22 3 | | EWS/FLI1-Activated Transcript 22 3 | | SH2 Domain-Containing Molecule EAT22 | | SH2 Domain-Containing Protein 1B2 |
Export aliases for SH2D1B gene to outside databasesPrevious GC identifers: GC01M159097 GC01M160631 GC01M133609 |
Summaries
for SH2D1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SH2D1B:
By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signaltransduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 (PubMed11689425)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: SH21B_HUMAN, O14796Function: Plays a role in controlling signal transduction through at least four receptors, CD84, SLAMF1, LY9 and CD244,expressed on the surface of professional antigen-presenting cells
Gene Wiki entry for SH2D1B
|
Genomic Views
for SH2D1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SH2D1B gene promoter:
AhR NF-1 ISGF-3 HSF2 Arnt Evi-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SH2D1B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH2D1B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q23.3 Ensembl cytogenetic band: 1q23.3 HGNC cytogenetic band: 1q23.3SH2D1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M162366: view genomic region
(about GC identifiers)
Start:
|
162,365,056 bp from pter |
End:
|
162,381,928 bp from pter |
Size:
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16,873 bases |
Orientation:
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minus strand |
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Proteins
for SH2D1B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SH21B_HUMAN, O14796 (See
protein sequence)Recommended Name: SH2 domain-containing protein 1B Size: 132 amino acids; 15297 Da
Subunit: Binds to the phosphorylated receptors CD84, SLAMF1, LY9 and CD244. Does not bind to non-phosphorylated SLAMF1
Secondary accessions: B2RBN6 Q5T0L1 Q8NI18 Q969K9Alternative splicing: 2 isoforms: O14796-1 O14796-2 Explore the universe of human proteins at neXtProt for SH2D1B: NX_O14796
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O14796
SH2D1B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_444512.2
ENSEMBL proteins: ENSP00000356906 ENSP00000352571
Human Recombinant Protein Products for SH2D1B:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
SH2D1B for ontologies About GeneDecksing
SH2D1B Antibody Products:
Assay Products for SH2D1B: |
Protein
Domains /
Families
for SH2D1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SH2D1B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O14796ProtoNet protein and cluster: O14796 1 Blocks protein family: IPB000980 SH2 domain signature
UniProtKB/Swiss-Prot: SH21B_HUMAN, O14796Similarity: Contains 1 SH2 domain |
Function
for SH2D1B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SH21B_HUMAN, O14796Function: Plays a role in controlling signal transduction through at least four receptors, CD84, SLAMF1, LY9 and CD244,expressed on the surface of professional antigen-presenting cells Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
SH2D1B for ontologies About GeneDecksing
Phenotypes:
1 MGI mutant phenotype (inferred from 5 alleles ) (MGI details for Sh2d1b1):
SH2D1B for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for SH2D1B: Sh2d1b1tm1.1Cpt Sh2d1b1tm3Vei Sh2d1b1tm1Vei Sh2d1b1tm2Vei Sh2d1b1/Sh2d1b2Sh2d1b1/tm1.1Cpt
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SH2D1B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SH2D1B (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH2D1B |
|
Pathways & Interactions
for SH2D1B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Natural killer cell mediated cytotoxicity | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for SH2D1B):
SH2D1B for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SH2D1B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/6 Interacting proteins for SH2D1B (O147962, 3 ENSP000003569064) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002366 | leukocyte activation involved in immune response |
ISS | -- | | GO:0002717 | positive regulation of natural killer cell mediated immunity |
ISS | -- | | GO:0045089 | positive regulation of innate immune response |
ISS | -- |
SH2D1B for ontologies About GeneDecksing
|
Drugs & Compounds
for SH2D1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SH2D1B for compounds About GeneDecksing
 Browse Tocris compounds for SH2D1B
1 Novoseek chemical compound relationship for SH2D1B gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tyrosine |
25.1 |
3 |
11689425 (1), 16425036 (1) |
Search CenterWatch for drugs/clinical trials and news about SH2D1B / SH21B
|
Transcripts
for SH2D1B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SH2D1B gene: NM_053282.4 Unigene Cluster for SH2D1B: SH2 domain containing 1B Hs.350581 [show with all ESTs]Unigene Representative Sequence: NM_0532823 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000367929(uc001gbz.1 uc001gca.1) ENST00000493550 ENST00000359567
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SH2D1B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SH2D1B (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SH2D1B (NM_053282) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SH2D1B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH2D1B |
Additional cDNA sequence: AF256653.1 AF403479.1 AF484964.1 AK097162.1 AK314743.1 BC022407.1 BC066595.1 3 DOTS entries: DT.91807987 DT.97835481 DT.97764427 22 AceView cDNA sequences: AF403479 BC066595 AF484964 CD521440 BC022407 BM922409 AL709120 AW613569 CD641560 BF375549 CD521821 AK097162 NM_053282 AF256653 AA318738 CD707235 BG569733 BI912061 CD639517 BE896279 CD639168 CD703272
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SH2D1B About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b |
|---|
|
| SP1: | | | | | - | | | | - | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | - | | | | - | | - | | | | | | |
| SP4: | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for SH2D1B
|
Expression
for SH2D1B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SH2D1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGTCATAAA
About this image
See SH2D1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SH2D1B
SOURCE GeneReport for Unigene cluster: Hs.350581
SABiosciences Custom PCR Arrays for SH2D1B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SH2D1B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SH2D1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SH2D1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SH2D1B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH2D1B |
Orthologs
for SH2D1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SH2D1B gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for SH2D1B (if available)
TreeFam Gene Tree for SH2D1B (if available) |
Paralogs
for SH2D1B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SH2D1B gene
- SH2D1A2
4 SIMAP similar genes for SH2D1B using alignment to 1 protein entry: SH21B_HUMAN:SH2D1A INPPL1 INPP5D LCK
SH2D1B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SH2D1B
PGOHUM00000244315
|
Genomic Variants
for SH2D1B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SH2D1B (162365056 - 162381928 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SH2D1B
3 CNVs: 3317 8336 48150 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SH2D1B |
|
Disorders
/ Diseases
for SH2D1B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SH2D1B for disorders About GeneDecksing
OMIM gene information: 608510
OMIM disorders: --
2  diseases for SH2D1B: About MalaCardssarcoma immunodeficiency
Export disorders for SH2D1B gene to outside databases
|
Publications
for SH2D1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SH2D1B gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with SH2D1B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. (PubMed id 11689425)1, 2, 3, 9 Morra M.... Terhorst C. (2001)
- EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene. (PubMed id 9000139)1, 2, 3 Thompson A.D.... Denny C. (1996)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2. (PubMed id 12115647)1, 2 Tangye S.G.... Hodgkin P.D. (2002)
- Identification and characterization of two related murine genes, Eat2a and Eat2b, encoding single SH2-domain adapters. (PubMed id 16425036)1, 9 Calpe S....Lanyi A. (2006)
- SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential inter actome. (PubMed id 22974441)1 Liu B.A....Nash P.D. (2012)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Molecular analysis of NTB-A signaling: a role for EAT-2 in NTB-A-mediated activation of human NK cells. (PubMed id 16920955)1 Eissmann P. and Watzl C. (2006)
|
External Searches for SH2D1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SH2D1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SH2D1B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SH2D1B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SH2D1B gene:
Search GeneIP for patents involving SH2D1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SH2D1B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for SH2D1B | | OriGene Custom Protein Services for SH2D1B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SH2D1B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SH2D1B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH2D1B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SH2D1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SH2D1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SH2D1B |
| |
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| |  |  |  |  | | | | |
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 |
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 | | | SH2D1B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH2D1B |
|  |  |  |  | | | | ThermoFisher Antibody for SH2D1B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SH2D1B |
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