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Aliases for SH2D1B Gene

Aliases for SH2D1B Gene

  • SH2 Domain Containing 1B 2 3
  • EAT2 3 4 6
  • EWS/FLI1-Activated Transcript 2 3 4
  • EAT-2 3 4
  • SH2 Domain-Containing Molecule EAT2 3
  • SH2 Domain-Containing Protein 1B 3

External Ids for SH2D1B Gene

Summaries for SH2D1B Gene

Entrez Gene Summary for SH2D1B Gene

  • By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SH2D1B Gene

SH2D1B (SH2 Domain Containing 1B) is a Protein Coding gene. Among its related pathways are Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include protein binding, bridging and SH3/SH2 adaptor activity. An important paralog of this gene is SH2D1A.

UniProtKB/Swiss-Prot for SH2D1B Gene

  • Plays a role in controlling signal transduction through at least four receptors, CD84, SLAMF1, LY9 and CD244, expressed on the surface of professional antigen-presenting cells

Gene Wiki entry for SH2D1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH2D1B Gene

Genomics for SH2D1B Gene

Genomic Location for SH2D1B Gene

Start:
162,395,266 bp from pter
End:
162,412,138 bp from pter
Size:
16,873 bases
Orientation:
Minus strand

Genomic View for SH2D1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SH2D1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH2D1B Gene

Regulatory Elements for SH2D1B Gene

Proteins for SH2D1B Gene

  • Protein details for SH2D1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14796-SH21B_HUMAN
    Recommended name:
    SH2 domain-containing protein 1B
    Protein Accession:
    O14796
    Secondary Accessions:
    • B2RBN6
    • Q5T0L1
    • Q8NI18
    • Q969K9

    Protein attributes for SH2D1B Gene

    Size:
    132 amino acids
    Molecular mass:
    15297 Da
    Quaternary structure:
    • Binds to the phosphorylated receptors CD84, SLAMF1, LY9 and CD244. Does not bind to non-phosphorylated SLAMF1

    Alternative splice isoforms for SH2D1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SH2D1B Gene

Proteomics data for SH2D1B Gene at MOPED

Post-translational modifications for SH2D1B Gene

No Post-translational modifications

Other Protein References for SH2D1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SH2D1B Gene

Domains for SH2D1B Gene

Gene Families for SH2D1B Gene

HGNC:
  • SH2D :SH2 domain containing

Protein Domains for SH2D1B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SH2D1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14796

UniProtKB/Swiss-Prot:

SH21B_HUMAN
Domain:
  • Contains 1 SH2 domain.:
    • O14796
genes like me logo Genes that share domains with SH2D1B: view

Function for SH2D1B Gene

Molecular function for SH2D1B Gene

UniProtKB/Swiss-Prot Function: Plays a role in controlling signal transduction through at least four receptors, CD84, SLAMF1, LY9 and CD244, expressed on the surface of professional antigen-presenting cells

Gene Ontology (GO) - Molecular Function for SH2D1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12928397
GO:0030674 protein binding, bridging TAS 16425036
genes like me logo Genes that share ontologies with SH2D1B: view

Phenotypes for SH2D1B Gene

genes like me logo Genes that share phenotypes with SH2D1B: view

Animal Models for SH2D1B Gene

MGI Knock Outs for SH2D1B:

miRNA for SH2D1B Gene

miRTarBase miRNAs that target SH2D1B

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SH2D1B Gene

Localization for SH2D1B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SH2D1B Gene COMPARTMENTS Subcellular localization image for SH2D1B gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SH2D1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 16920955
genes like me logo Genes that share ontologies with SH2D1B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SH2D1B Gene

Pathways for SH2D1B Gene

genes like me logo Genes that share pathways with SH2D1B: view

Pathways by source for SH2D1B Gene

1 KEGG pathway for SH2D1B Gene

Gene Ontology (GO) - Biological Process for SH2D1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002366 leukocyte activation involved in immune response ISS --
GO:0002717 positive regulation of natural killer cell mediated immunity ISS --
GO:0045089 positive regulation of innate immune response ISS --
genes like me logo Genes that share ontologies with SH2D1B: view

Compounds for SH2D1B Gene

(1) Novoseek inferred chemical compound relationships for SH2D1B Gene

Compound -log(P) Hits PubMed IDs
tyrosine 25.1 2
genes like me logo Genes that share compounds with SH2D1B: view

Transcripts for SH2D1B Gene

mRNA/cDNA for SH2D1B Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SH2D1B Gene

SH2 domain containing 1B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SH2D1B Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: - -
SP2: -
SP3: - - -
SP4: -

Relevant External Links for SH2D1B Gene

GeneLoc Exon Structure for
SH2D1B
ECgene alternative splicing isoforms for
SH2D1B

Expression for SH2D1B Gene

mRNA expression in normal human tissues for SH2D1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH2D1B Gene

This gene is overexpressed in Whole Blood (20.1), Muscle - Skeletal (15.4), and Spleen (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SH2D1B Gene

SOURCE GeneReport for Unigene cluster for SH2D1B Gene Hs.350581

genes like me logo Genes that share expressions with SH2D1B: view

No data available for mRNA Expression by UniProt/SwissProt for SH2D1B Gene

Orthologs for SH2D1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for SH2D1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SH2D1B 35
  • 99.24 (n)
  • 99.24 (a)
SH2D1B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SH2D1B 35
  • 84.6 (n)
  • 76.52 (a)
SH2D1B 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SH2D1B 35
  • 79.39 (n)
  • 71.76 (a)
SH2D1B 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sh2d1b1 35
  • 80.05 (n)
  • 65.15 (a)
Sh2d1b1 16
Sh2d1b1 36
  • 64 (a)
OneToMany
Sh2d1b2 36
  • 65 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SH2D1B 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sh2d1b 35
  • 77.27 (n)
  • 65.15 (a)
chicken
(Gallus gallus)
Aves SH2D1B 35
  • 60.31 (n)
  • 49.62 (a)
SH2D1B 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SH2D1B 36
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486929 35
  • 59.26 (n)
  • 53.17 (a)
zebrafish
(Danio rerio)
Actinopterygii SH2D1B 36
  • 38 (a)
OneToOne
si:dkey-11p10.10 35
  • 51.77 (n)
  • 43.94 (a)
Species with no ortholog for SH2D1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SH2D1B Gene

ENSEMBL:
Gene Tree for SH2D1B (if available)
TreeFam:
Gene Tree for SH2D1B (if available)

Paralogs for SH2D1B Gene

Paralogs for SH2D1B Gene

Selected SIMAP similar genes for SH2D1B Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SH2D1B Gene

genes like me logo Genes that share paralogs with SH2D1B: view

Variants for SH2D1B Gene

Sequence variations from dbSNP and Humsavar for SH2D1B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs164122 -- 162,398,567(-) CCAAA(A/G)CGTAT intron-variant
rs164123 -- 162,397,864(-) AGGAA(C/T)GTATC intron-variant
rs164124 -- 162,397,445(+) AAGTT(A/G)TATCT intron-variant
rs164126 -- 162,395,869(-) TTTTC(C/T)CATGC utr-variant-3-prime
rs164132 -- 162,412,849(+) TTCTT(C/T)TTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SH2D1B Gene

Variant ID Type Subtype PubMed ID
dgv141e1 CNV Complex 17122850
dgv399n71 CNV Gain 21882294
esv34209 CNV Gain 17911159
nsv516482 CNV Gain+Loss 19592680

Relevant External Links for SH2D1B Gene

HapMap Linkage Disequilibrium report
SH2D1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH2D1B Gene

Disorders for SH2D1B Gene

No disorders were found for SH2D1B Gene.

No data available for UniProtKB/Swiss-Prot for SH2D1B Gene

Publications for SH2D1B Gene

  1. Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. (PMID: 11689425) Morra M. … Terhorst C. (EMBO J. 2001) 2 3 4 23
  2. EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene. (PMID: 9000139) Thompson A.D. … Denny C. (Oncogene 1996) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Identification and characterization of two related murine genes, Eat2a and Eat2b, encoding single SH2-domain adapters. (PMID: 16425036) Calpe S. … Lanyi A. (Immunogenetics 2006) 3 23

Products for SH2D1B Gene

Sources for SH2D1B Gene

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