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Aliases for SH2B2 Gene

Aliases for SH2B2 Gene

  • SH2B Adaptor Protein 2 2 3
  • APS 3 4 6
  • Adapter Protein With Pleckstrin Homology And Src Homology 2 Domains 3 4
  • SH2 And PH Domain-Containing Adapter Protein APS 3 4
  • Adaptor Protein With Pleckstrin Homology And Src 2
  • SH2B Adapter Protein 2 3

External Ids for SH2B2 Gene

Summaries for SH2B2 Gene

Entrez Gene Summary for SH2B2 Gene

  • The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]

GeneCards Summary for SH2B2 Gene

SH2B2 (SH2B Adaptor Protein 2) is a Protein Coding gene. Among its related pathways are PI-3K cascade and Signaling by GPCR. GO annotations related to this gene include phospholipid binding and SH3/SH2 adaptor activity. An important paralog of this gene is SH2B3.

UniProtKB/Swiss-Prot for SH2B2 Gene

  • Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3.

Gene Wiki entry for SH2B2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH2B2 Gene

Genomics for SH2B2 Gene

Genomic Location for SH2B2 Gene

Start:
102,285,068 bp from pter
End:
102,321,711 bp from pter
Size:
36,644 bases
Orientation:
Plus strand

Genomic View for SH2B2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SH2B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH2B2 Gene

Regulatory Elements for SH2B2 Gene

Proteins for SH2B2 Gene

  • Protein details for SH2B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14492-SH2B2_HUMAN
    Recommended name:
    SH2B adapter protein 2
    Protein Accession:
    O14492
    Secondary Accessions:
    • A6ND74

    Protein attributes for SH2B2 Gene

    Size:
    632 amino acids
    Molecular mass:
    67738 Da
    Quaternary structure:
    • Homodimer. Interacts with KIT/c-KIT, SHC1, EPOR, PDGFR, VAV1 and VAV3. Interacts (via N-terminal region) with SHC1. Interacts (via the phosphorylated C-terminus) with GRB2. Interacts (via its SH2 domain) with EPOR, INSR and KIT. Interacts with GRB2 after B-cell antigen receptor stimulation. Interacts (via PH domain) with VAV3. Interacts with NTRK1, NTRK2 and NTRK3 (phosphorylated); after stimulation of the receptor by its extracellular ligand and subsequent autophosphorylation of the receptor. Binds INSR, GRB2, ASB6 and CAP. Insulin stimulation leads to dissociation of CAP. Binds CBS only when SH2B2/APS has become phosphorylated. INSR binding does not depend on the phosphorylation of SH2B2/APS (By similarity).

    Three dimensional structures from OCA and Proteopedia for SH2B2 Gene

neXtProt entry for SH2B2 Gene

Proteomics data for SH2B2 Gene at MOPED

Post-translational modifications for SH2B2 Gene

  • Tyrosine phosphorylated by JAK2, KIT and other kinases activated by B-cell receptor in response to stimulation with cytokines, IL3, IL5, PDGF, IGF1, IGF2, CSF2/GM-CSF and cross-linking of the B-cell receptor complex.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SH2B2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SH2B2 Gene

Domains for SH2B2 Gene

Gene Families for SH2B2 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing
  • SH2D :SH2 domain containing

Protein Domains for SH2B2 Gene

UniProtKB/Swiss-Prot:

SH2B2_HUMAN
Domain:
  • Contains 1 PH domain.:
    • O14492
  • Contains 1 SH2 domain.:
    • O14492
Family:
  • Belongs to the SH2B adapter family.:
    • O14492
genes like me logo Genes that share domains with SH2B2: view

Function for SH2B2 Gene

Molecular function for SH2B2 Gene

UniProtKB/Swiss-Prot Function: Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3.

Gene Ontology (GO) - Molecular Function for SH2B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity --
GO:0005070 SH3/SH2 adaptor activity IDA 9233773
GO:0005515 protein binding IPI 15737992
GO:0008269 JAK pathway signal transduction adaptor activity IDA 10374881
genes like me logo Genes that share ontologies with SH2B2: view
genes like me logo Genes that share phenotypes with SH2B2: view

Animal Models for SH2B2 Gene

MGI Knock Outs for SH2B2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SH2B2 Gene

Localization for SH2B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH2B2 Gene

Cytoplasm. Cell membrane. Note=Cytoplasmic before PDGF stimulation. After PDGF stimulation, localized at the cell membrane and peripheral region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SH2B2 Gene COMPARTMENTS Subcellular localization image for SH2B2 gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for SH2B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber --
GO:0001726 ruffle --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005884 actin filament --
genes like me logo Genes that share ontologies with SH2B2: view

Pathways for SH2B2 Gene

genes like me logo Genes that share pathways with SH2B2: view

Pathways by source for SH2B2 Gene

Gene Ontology (GO) - Biological Process for SH2B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001922 B-1 B cell homeostasis --
GO:0007165 signal transduction TAS 9233773
GO:0007399 nervous system development --
GO:0007596 blood coagulation TAS --
GO:0008286 insulin receptor signaling pathway ISS --
genes like me logo Genes that share ontologies with SH2B2: view

Compounds for SH2B2 Gene

(2) Novoseek inferred chemical compound relationships for SH2B2 Gene

Compound -log(P) Hits PubMed IDs
phosphotyrosine 62.6 2
tyrosine 52.9 19
genes like me logo Genes that share compounds with SH2B2: view

Transcripts for SH2B2 Gene

mRNA/cDNA for SH2B2 Gene

Unigene Clusters for SH2B2 Gene

SH2B adaptor protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SH2B2 Gene

No ASD Table

Relevant External Links for SH2B2 Gene

GeneLoc Exon Structure for
SH2B2
ECgene alternative splicing isoforms for
SH2B2

Expression for SH2B2 Gene

mRNA expression in normal human tissues for SH2B2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH2B2 Gene

This gene is overexpressed in Whole Blood (11.3) and Muscle - Skeletal (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SH2B2 Gene

SOURCE GeneReport for Unigene cluster for SH2B2 Gene Hs.489448

mRNA Expression by UniProt/SwissProt for SH2B2 Gene

O14492-SH2B2_HUMAN
Tissue specificity: Expressed in spleen, prostate, testis, uterus, small intestine and skeletal muscle. Among hematopoietic cell lines, expressed exclusively in B-cells. Not expressed in most tumor cell lines.
genes like me logo Genes that share expressions with SH2B2: view

Orthologs for SH2B2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SH2B2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SH2B2 36
  • 99.55 (n)
  • 99.55 (a)
SH2B2 37
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SH2B2 36
  • 88.43 (n)
  • 89.01 (a)
SH2B2 37
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SH2B2 36
  • 87.58 (n)
  • 88.35 (a)
SH2B2 37
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sh2b2 36
  • 80.12 (n)
  • 84.25 (a)
Sh2b2 16
Sh2b2 37
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SH2B2 37
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SH2B2 37
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sh2b2 36
  • 80.01 (n)
  • 83.92 (a)
chicken
(Gallus gallus)
Aves SH2B2 36
  • 70.77 (n)
  • 67.12 (a)
SH2B2 37
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SH2B2 37
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488327 36
  • 61.46 (n)
  • 64.18 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100535524 36
  • 64.25 (n)
  • 63.15 (a)
SH2B2 37
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Lnk 37
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 40 (a)
OneToMany
Species with no ortholog for SH2B2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SH2B2 Gene

ENSEMBL:
Gene Tree for SH2B2 (if available)
TreeFam:
Gene Tree for SH2B2 (if available)

Paralogs for SH2B2 Gene

Paralogs for SH2B2 Gene

Selected SIMAP similar genes for SH2B2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SH2B2: view

Variants for SH2B2 Gene

Sequence variations from dbSNP and Humsavar for SH2B2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs15613 -- 102,308,823(+) GAGAA(C/T)GGAGC synonymous-codon, reference
rs712842 -- 102,297,475(-) AACCC(C/T)AGCAG intron-variant
rs712843 -- 102,306,595(+) TGGGA(A/T)ACCTC intron-variant
rs726890 -- 102,296,494(+) TATTG(A/G)TAATT intron-variant
rs803072 -- 102,284,885(+) AGCAT(A/G)TGTAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SH2B2 Gene

Variant ID Type Subtype PubMed ID
nsv509218 CNV Insertion 20534489
nsv831082 CNV Gain 17160897
dgv2121e1 CNV Complex 17122850
nsv428182 CNV Gain 18775914
nsv888828 CNV Loss 21882294
nsv888829 CNV Loss 21882294
nsv888830 CNV Loss 21882294
esv998770 CNV Insertion 20482838
esv1453362 CNV Insertion 17803354

Relevant External Links for SH2B2 Gene

HapMap Linkage Disequilibrium report
SH2B2

Disorders for SH2B2 Gene

Relevant External Links for SH2B2

Human Genome Epidemiology (HuGE) Navigator
SH2B2
genes like me logo Genes that share disorders with SH2B2: view

No data available for UniProtKB/Swiss-Prot for SH2B2 Gene

Publications for SH2B2 Gene

  1. Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation. (PMID: 9233773) Yokouchi M. … Yoshimura A. (Oncogene 1997) 2 3 4 23
  2. APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis. (PMID: 9989826) Yokouchi M. … Yoshimura A. (Oncogene 1999) 3 4 23
  3. APS, an adaptor protein containing pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl. (PMID: 10374881) Wakioka T. … Yoshimura A. (Leukemia 1999) 3 4 23
  4. SH2-B family members differentially regulate JAK family tyrosine kinases. (PMID: 11751854) O'Brien K.B. … Carter-Su C. (J. Biol. Chem. 2002) 3 23
  5. Identification of the APS protein as a novel insulin receptor substrate. (PMID: 10196204) Moodie S.A. … Gustafson T.A. (J. Biol. Chem. 1999) 3 23

Products for SH2B2 Gene

Sources for SH2B2 Gene

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