SH2B2 Gene
protein-coding GIFtS: 56
GCID: GC07P101928
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|
SH2B adaptor protein 2
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Aliases
for SH2B2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SH2B Adaptor Protein 21 2 | | APS1 2 3 5 | | Adapter Protein With Pleckstrin Homology And Src Homology 2 Domains2 3 | | SH2 And PH Domain-Containing Adapter Protein APS2 3 | | Adaptor Protein With Pleckstrin Homology And Src Homology 2 Domains2 | | SH2B Adapter Protein 22 |
Export aliases for SH2B2 gene to outside databasesPrevious GC identifers: GC07P101715 GC07P096518 |
Summaries
for SH2B2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SH2B2:
The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2(SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptorstimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role insignal transduction from the receptor to the Shc/Grb2 pathway. (provided by RefSeq, Jun 2009)
UniProtKB/Swiss-Prot: SH2B2_HUMAN, O14492Function: Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signalingpathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokinesignaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through amasking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletalreorganization via interaction with VAV3
Gene Wiki entry for SH2B2
|
Genomic Views
for SH2B2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SH2B2 gene promoter:
AhR Pax-2b GATA-3 Pax-2 Pax-2a RelA NF-kappaB NF-kappaB1 GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SH2B2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SH2B2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q22 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22.1SH2B2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P101928: view genomic region
(about GC identifiers)
Start:
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101,928,405 bp from pter |
End:
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101,962,178 bp from pter |
Size:
|
33,774 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 101,285,864-101,322,461 |
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Proteins
for SH2B2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SH2B2_HUMAN, O14492 (See
protein sequence)Recommended Name: SH2B adapter protein 2 Size: 632 amino acids; 67738 Da
Subunit: Homodimer. Interacts with KIT/c-KIT, SHC1, EPOR, PDGFR, VAV1 and VAV3. Interacts (via N-terminal region) withSHC1. Interacts (via the phosphorylated C-terminus) with GRB2. Interacts (via its SH2 domain) with EPOR, INSR and KIT.Interacts with GRB2 after B-cell antigen receptor stimulation. Interacts (via PH domain) with VAV3. Interacts withNTRK1, NTRK2 and NTRK3 (phosphorylated); after stimulation of the receptor by its extracellular ligand and subsequentautophosphorylation of the receptor. Binds INSR, GRB2, ASB6 and CAP. Insulin stimulation leads to dissociation of CAP.Binds CBS only when SH2B2/APS has become phosphorylated. INSR binding does not depend on the phosphorylation ofSH2B2/APS (By similarity)
Subcellular location: Cytoplasm. Cell membrane. Note=Cytoplasmic before PDGF stimulation. After PDGF stimulation,localized at the cell membrane and peripheral region
1 PDB 3D structure from  and Proteopedia  for SH2B2:1Q2H (3D)
Secondary accessions: A6ND74Explore the universe of human proteins at neXtProt for SH2B2: NX_O14492
Post-translational modifications:
Tyrosine phosphorylated by JAK2, KIT and other kinases activated by B-cell receptor in response to stimulation withcytokines, IL3, IL5, PDGF, IGF1, IGF2, CSF2/GM-CSF and cross-linking of the B-cell receptor complex1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O14492
SH2B2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_066189.3
ENSEMBL proteins: ENSP00000401883 ENSP00000415306 ENSP00000440273 ENSP00000304701 Reactome Protein details: O14492
Human Recombinant Protein Products for SH2B2:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
SH2B2 for ontologies About GeneDecksing
SH2B2 Antibody Products:
Assay Products for SH2B2: |
Protein
Domains /
Families
for SH2B2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SH2B2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O14492ProtoNet protein and cluster: O14492 2 Blocks protein families: IPB000980 SH2 domain signature IPB001849 Pleckstrin-like
UniProtKB/Swiss-Prot: SH2B2_HUMAN, O14492Similarity: Belongs to the SH2B adapter familySimilarity: Contains 1 PH domainSimilarity: Contains 1 SH2 domain |
Function
for SH2B2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SH2B2_HUMAN, O14492Function: Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signalingpathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokinesignaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through amasking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletalreorganization via interaction with VAV3 Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
SH2B2 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for SH2B2:
4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Sh2b2):
SH2B2 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Sh2b2tm1Yeb for SH2B2
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SH2B2 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH2B2 |
|
Pathways & Interactions
for SH2B2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Development_EPO-induced Jak-STAT pathway | | | 2 | Signaling events mediated by Stem cell factor receptor (c-Kit) | | | 3 | Tyrosine Kinases / Adaptors | | | 4 | Factors involved in megakaryocyte development and platelet production | | | 5 | B Cell Receptor Signaling Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for SH2B2
1 
Cell Signaling Technology (CST) Pathway for SH2B2
1  GeneGo (Thomson Reuters) Pathway for SH2B2
5/7  BioSystems Pathways for SH2B2 (see all 7)
5 
Reactome Pathways for SH2B2
2 
Kegg Pathways (Kegg details for SH2B2):
SH2B2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SH2B2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/37 Interacting proteins for SH2B2 (O144922, 3 ENSP000003047014) via UniProtKB, MINT, STRING, and/or I2D (see all 37)About this table
Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table
SH2B2 for ontologies About GeneDecksing
|
Drugs & Compounds
for SH2B2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SH2B2 for compounds About GeneDecksing
 Browse Tocris compounds for SH2B2
2 Novoseek chemical compound relationships for SH2B2 gene About this table
Search CenterWatch for drugs/clinical trials and news about SH2B2
|
Transcripts
for SH2B2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SH2B2 gene: NM_020979.3 Unigene Cluster for SH2B2: SH2B adaptor protein 2 Hs.489448 [show with all ESTs]Unigene Representative Sequence: NM_0209794 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000444095 ENST00000432527 ENST00000536178(uc011kko.2) ENST00000306803
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SH2B2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SH2B2 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SH2B2 (NM_020979) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SH2B2 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SH2B2 |
Additional cDNA sequence: AB000520.1 4 DOTS entries: DT.313212 DT.96086296 DT.121618749 DT.40131743 24/55 AceView cDNA sequences (see all 55): BE676726 BE221400 AI076208 BF434397 AI339417 BM714204 AI701027 BF591037 BP429974 BI114718 AW402997 AW206092 AA721379 BI261466 AI937524 AI083671 AI480246 BX283854 AI656825 BM551939 AA810490 AA972885 BE295393 AW628658
GeneLoc Exon Structure
|
Expression
for SH2B2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SH2B2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCCGCCACT
About this image
See SH2B2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SH2B2
SOURCE GeneReport for Unigene cluster: Hs.489448
UniProtKB/Swiss-Prot: SH2B2_HUMAN, O14492Tissue specificity: Expressed in spleen, prostate, testis, uterus, small intestine and skeletal muscle. Amonghematopoietic cell lines, expressed exclusively in B-cells. Not expressed in most tumor cell lines
SABiosciences Custom PCR Arrays for SH2B2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SH2B2
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH2B2 |
Orthologs
for SH2B2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SH2B2 gene from 4/17 species (see all 17) About this table
ENSEMBL Gene Tree for SH2B2 (if available)
TreeFam Gene Tree for SH2B2 (if available) |
Paralogs
for SH2B2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SH2B2 gene
- SH2B32 SH2B12
3 SIMAP similar genes for SH2B2 using alignment to 4 protein entries: SH2B2_HUMAN (see all proteins):SH2B1 SHC3 PTPN11
SH2B2 for paralogs About GeneDecksing
|
Genomic Variants
for SH2B2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SH2B2 (101928405 - 101962178 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SH2B2
2 CNVs: 23820 3693 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for SH2B2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SH2B2 for disorders About GeneDecksing
OMIM gene information: 605300
OMIM disorders: --
7  diseases for SH2B2: About MalaCardsburkitt's lymphoma myeloproliferative disorder cblc hepatitis b
hepatitis prostatitis neuronitis
Human Genome Epidemiology (HuGE) Navigator: SH2B2 (3 documents)
Export disorders for SH2B2 gene to outside databases
|
Publications
for SH2B2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SH2B2 gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with SH2B2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation. (PubMed id 9233773)1, 2, 3, 9 Yokouchi M....Yoshimura A. (1997)
- APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis. (PubMed id 9989826)1, 2, 9 Yokouchi M.... Yoshimura A. (1999)
- APS, an adaptor protein containing pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl. (PubMed id 10374881)1, 2, 9 Wakioka T....Yoshimura A. (1999)
- Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity. (PubMed id 12400014)1, 2 Yabana N. and Shibuya M. (2002)
- Identification of the APS protein as a novel insulin receptor substrate. (PubMed id 10196204)1, 9 Moodie S.A....Gustafson T.A. (1999)
- SH2-B family members differentially regulate JAK family tyrosine kinases. (PubMed id 11751854)1, 9 O'Brien K.B.... Carter-Su C. (2002)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Lnk inhibits myeloproliferative disorder-associated J AK2 mutant, JAK2V617F. (PubMed id 19293402)1 Gery S....Koeffler H.P. (2009)
- Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates. (PubMed id 18273061)1 Ng C....Sivaraman J. (2008)
- The association between the SH2-containing inositol po lyphosphate 5-Phosphatase 2 (SHIP2) and the adaptor protein APS has an impact on biochemical properties of both partners. (PubMed id 17620296)1 Onnockx S....Pirson I. (2008)
|
External Searches for SH2B2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SH2B2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SH2B2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SH2B2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SH2B2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SH2B2 gene:
Search GeneIP for patents involving SH2B2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SH2B2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SH2B2 |
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