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Aliases for SGTB Gene

Aliases for SGTB Gene

  • Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, Beta 2 3
  • Small Glutamine-Rich Protein With Tetratricopeptide Repeats 2 3 4
  • Beta-SGT 3 4
  • SGT2 3 4
  • Small Glutamine Rich Protein With Tetratricopeptide Repeats 2 3

External Ids for SGTB Gene

Previous GeneCards Identifiers for SGTB Gene

  • GC05M064980
  • GC05M064979
  • GC05M065000
  • GC05M061917

Summaries for SGTB Gene

GeneCards Summary for SGTB Gene

SGTB (Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, Beta) is a Protein Coding gene. An important paralog of this gene is TTC12.

UniProtKB/Swiss-Prot for SGTB Gene

  • Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGTB Gene

Genomics for SGTB Gene

Regulatory Elements for SGTB Gene

Genomic Location for SGTB Gene

Chromosome:
5
Start:
65,665,928 bp from pter
End:
65,723,035 bp from pter
Size:
57,108 bases
Orientation:
Minus strand

Genomic View for SGTB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SGTB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGTB Gene

Proteins for SGTB Gene

  • Protein details for SGTB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EQ0-SGTB_HUMAN
    Recommended name:
    Small glutamine-rich tetratricopeptide repeat-containing protein beta
    Protein Accession:
    Q96EQ0

    Protein attributes for SGTB Gene

    Size:
    304 amino acids
    Molecular mass:
    33429 Da
    Quaternary structure:
    • Homooligomerize.

neXtProt entry for SGTB Gene

Proteomics data for SGTB Gene at MOPED

Post-translational modifications for SGTB Gene

  • Ubiquitination at Lys 5
  • Modification sites at PhosphoSitePlus

Other Protein References for SGTB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SGTB Gene

Domains & Families for SGTB Gene

Gene Families for SGTB Gene

Protein Domains for SGTB Gene

Suggested Antigen Peptide Sequences for SGTB Gene

Graphical View of Domain Structure for InterPro Entry

Q96EQ0

UniProtKB/Swiss-Prot:

SGTB_HUMAN :
  • Belongs to the SGT family.
  • Contains 4 TPR repeats.
Family:
  • Belongs to the SGT family.
Similarity:
  • Contains 4 TPR repeats.
genes like me logo Genes that share domains with SGTB: view

Function for SGTB Gene

Molecular function for SGTB Gene

UniProtKB/Swiss-Prot Function:
Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.

Gene Ontology (GO) - Molecular Function for SGTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with SGTB: view

Animal Model Products

miRNA for SGTB Gene

miRTarBase miRNAs that target SGTB

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SGTB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for SGTB Gene

Localization for SGTB Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SGTB Gene

Pathways & Interactions for SGTB Gene

SuperPathways for SGTB Gene

No Data Available

Gene Ontology (GO) - Biological Process for SGTB Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SGTB Gene

Drugs & Compounds for SGTB Gene

No Compound Related Data Available

Transcripts for SGTB Gene

mRNA/cDNA for SGTB Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SGTB Gene

Small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SGTB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SGTB Gene

No ASD Table

Relevant External Links for SGTB Gene

GeneLoc Exon Structure for
SGTB
ECgene alternative splicing isoforms for
SGTB

Expression for SGTB Gene

mRNA expression in normal human tissues for SGTB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SGTB Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.3) and Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for SGTB Gene

This gene is overexpressed in Bone (50.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SGTB Gene



SOURCE GeneReport for Unigene cluster for SGTB Gene Hs.482301

genes like me logo Genes that share expression patterns with SGTB: view

Protein tissue co-expression partners for SGTB Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SGTB Gene

Orthologs for SGTB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SGTB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SGTB 35
  • 94.3 (n)
  • 97.37 (a)
SGTB 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SGTB 35
  • 94.19 (n)
  • 98.03 (a)
SGTB 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sgtb 35
  • 87.72 (n)
  • 96.38 (a)
Sgtb 16
Sgtb 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SGTB 35
  • 99.67 (n)
  • 99.67 (a)
SGTB 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sgtb 35
  • 88.27 (n)
  • 96.05 (a)
oppossum
(Monodelphis domestica)
Mammalia SGTB 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
chicken
(Gallus gallus)
Aves SGTB 35
  • 80.37 (n)
  • 85.86 (a)
SGTB 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SGTB 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sgtb 35
  • 70.39 (n)
  • 74.01 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13292 35
zebrafish
(Danio rerio)
Actinopterygii sgta 35
  • 68.53 (n)
  • 73.68 (a)
sgtb 36
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003052 35
  • 49.94 (n)
  • 42.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sgt 35
  • 49.79 (n)
  • 39.15 (a)
Sgt 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sgt-1 36
  • 34 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR005W 35
  • 48.6 (n)
  • 36.55 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D01155g 35
  • 48.15 (n)
  • 39.46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGT2 35
  • 47.35 (n)
  • 37.5 (a)
SGT2 36
  • 28 (a)
OneToMany
TAH1 38
bread mold
(Neurospora crassa)
Ascomycetes NCU10273 35
  • 43.54 (n)
  • 37.6 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1142.02c 35
  • 50.26 (n)
  • 39.45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10634 36
  • 38 (a)
OneToMany
Species with no ortholog for SGTB:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SGTB Gene

ENSEMBL:
Gene Tree for SGTB (if available)
TreeFam:
Gene Tree for SGTB (if available)

Paralogs for SGTB Gene

Paralogs for SGTB Gene

(5) SIMAP similar genes for SGTB Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SGTB: view

Variants for SGTB Gene

Structural Variations from Database of Genomic Variants (DGV) for SGTB Gene

Variant ID Type Subtype PubMed ID
nsv517021 CNV Loss 19592680

Variation tolerance for SGTB Gene

Residual Variation Intolerance Score: 43.36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SGTB Gene

HapMap Linkage Disequilibrium report
SGTB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for SGTB Gene

Disorders for SGTB Gene

Relevant External Links for SGTB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SGTB
genes like me logo Genes that share disorders with SGTB: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SGTB Gene

Publications for SGTB Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 67
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 67

Products for SGTB Gene

Sources for SGTB Gene

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