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Aliases for SGTB Gene

Aliases for SGTB Gene

  • Small Glutamine Rich Tetratricopeptide Repeat Containing Beta 2 3
  • Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, Beta 2 3 5
  • Small Glutamine-Rich Protein With Tetratricopeptide Repeats 2 3 4
  • Beta-SGT 3 4
  • SGT2 3 4
  • Small Glutamine Rich Protein With Tetratricopeptide Repeats 2 3

External Ids for SGTB Gene

Previous GeneCards Identifiers for SGTB Gene

  • GC05M064980
  • GC05M064979
  • GC05M065000
  • GC05M061917

Summaries for SGTB Gene

GeneCards Summary for SGTB Gene

SGTB (Small Glutamine Rich Tetratricopeptide Repeat Containing Beta) is a Protein Coding gene. An important paralog of this gene is TTC12.

UniProtKB/Swiss-Prot for SGTB Gene

  • Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGTB Gene

Genomics for SGTB Gene

Regulatory Elements for SGTB Gene

Promoters for SGTB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SGTB on UCSC Golden Path with GeneCards custom track

Genomic Location for SGTB Gene

65,665,928 bp from pter
65,723,035 bp from pter
57,108 bases
Minus strand

Genomic View for SGTB Gene

Genes around SGTB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGTB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGTB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGTB Gene

Proteins for SGTB Gene

  • Protein details for SGTB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small glutamine-rich tetratricopeptide repeat-containing protein beta
    Protein Accession:

    Protein attributes for SGTB Gene

    304 amino acids
    Molecular mass:
    33429 Da
    Quaternary structure:
    • Homooligomerize.

neXtProt entry for SGTB Gene

Proteomics data for SGTB Gene at MOPED

Post-translational modifications for SGTB Gene

  • Ubiquitination at Lys 5
  • Modification sites at PhosphoSitePlus

Other Protein References for SGTB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SGTB Gene

Domains & Families for SGTB Gene

Gene Families for SGTB Gene

Protein Domains for SGTB Gene

Suggested Antigen Peptide Sequences for SGTB Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SGT family.
  • Contains 4 TPR repeats.
  • Belongs to the SGT family.
  • Contains 4 TPR repeats.
genes like me logo Genes that share domains with SGTB: view

Function for SGTB Gene

Molecular function for SGTB Gene

UniProtKB/Swiss-Prot Function:
Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.

Phenotypes for SGTB Gene

GenomeRNAi human phenotypes for SGTB:
genes like me logo Genes that share phenotypes with SGTB: view

Animal Model Products

miRNA for SGTB Gene

miRTarBase miRNAs that target SGTB

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SGTB Gene

Localization for SGTB Gene

Subcellular locations from

Jensen Localization Image for SGTB Gene COMPARTMENTS Subcellular localization image for SGTB gene
Compartment Confidence
cytosol 2
mitochondrion 2
peroxisome 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SGTB Gene

Pathways & Interactions for SGTB Gene

SuperPathways for SGTB Gene

No Data Available

Gene Ontology (GO) - Biological Process for SGTB Gene


No data available for Pathways by source and SIGNOR curated interactions for SGTB Gene

Drugs & Compounds for SGTB Gene

No Compound Related Data Available

Transcripts for SGTB Gene

mRNA/cDNA for SGTB Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SGTB Gene

Small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SGTB Gene

No ASD Table

Relevant External Links for SGTB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SGTB Gene

mRNA expression in normal human tissues for SGTB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SGTB Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.3) and Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for SGTB Gene

This gene is overexpressed in Bone (50.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SGTB Gene

SOURCE GeneReport for Unigene cluster for SGTB Gene Hs.482301

genes like me logo Genes that share expression patterns with SGTB: view

Protein tissue co-expression partners for SGTB Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SGTB Gene

Orthologs for SGTB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SGTB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SGTB 35
  • 94.3 (n)
  • 97.37 (a)
  • 97 (a)
(Canis familiaris)
Mammalia SGTB 35
  • 94.19 (n)
  • 98.03 (a)
  • 98 (a)
(Mus musculus)
Mammalia Sgtb 35
  • 87.72 (n)
  • 96.38 (a)
Sgtb 16
Sgtb 36
  • 96 (a)
(Pan troglodytes)
Mammalia SGTB 35
  • 99.67 (n)
  • 99.67 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Sgtb 35
  • 88.27 (n)
  • 96.05 (a)
(Monodelphis domestica)
Mammalia SGTB 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
-- 36
  • 51 (a)
(Gallus gallus)
Aves SGTB 35
  • 80.37 (n)
  • 85.86 (a)
  • 86 (a)
(Anolis carolinensis)
Reptilia SGTB 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sgtb 35
  • 70.39 (n)
  • 74.01 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13292 35
(Danio rerio)
Actinopterygii sgta 35
  • 68.53 (n)
  • 73.68 (a)
sgtb 36
  • 70 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003052 35
  • 49.94 (n)
  • 42.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sgt 35
  • 49.79 (n)
  • 39.15 (a)
Sgt 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea sgt-1 36
  • 34 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR005W 35
  • 48.6 (n)
  • 36.55 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D01155g 35
  • 48.15 (n)
  • 39.46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGT2 35
  • 47.35 (n)
  • 37.5 (a)
SGT2 36
  • 28 (a)
TAH1 38
bread mold
(Neurospora crassa)
Ascomycetes NCU10273 35
  • 43.54 (n)
  • 37.6 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1142.02c 35
  • 50.26 (n)
  • 39.45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10634 36
  • 38 (a)
Species with no ortholog for SGTB:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SGTB Gene

Gene Tree for SGTB (if available)
Gene Tree for SGTB (if available)

Paralogs for SGTB Gene

Paralogs for SGTB Gene

(5) SIMAP similar genes for SGTB Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SGTB: view

Variants for SGTB Gene

Sequence variations from dbSNP and Humsavar for SGTB Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs28342 -- 65,672,788(+) ATGTC(A/G)ACAAT intron-variant
rs112314 -- 65,686,494(+) TACCT(C/T)TATTC intron-variant
rs112315 -- 65,686,348(+) CCTGA(A/T)AATTT intron-variant
rs27136 -- 65,670,922(+) ATAAA(A/G)TGTCC intron-variant
rs27137 -- 65,670,691(+) TATAC(C/G)CAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SGTB Gene

Variant ID Type Subtype PubMed ID
nsv517021 CNV Loss 19592680

Variation tolerance for SGTB Gene

Residual Variation Intolerance Score: 43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SGTB Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SGTB Gene

Disorders for SGTB Gene

Relevant External Links for SGTB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SGTB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SGTB Gene

Publications for SGTB Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3

Products for SGTB Gene

Sources for SGTB Gene

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