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Aliases for SGTB Gene

Aliases for SGTB Gene

  • Small Glutamine Rich Tetratricopeptide Repeat Containing Beta 2 3 5
  • Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, Beta 2 3
  • Small Glutamine-Rich Protein With Tetratricopeptide Repeats 2 3 4
  • Beta-SGT 3 4
  • SGT2 3 4
  • Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Beta 3
  • Small Glutamine Rich Protein With Tetratricopeptide Repeats 2 3

External Ids for SGTB Gene

Previous GeneCards Identifiers for SGTB Gene

  • GC05M064980
  • GC05M064979
  • GC05M065000
  • GC05M061917

Summaries for SGTB Gene

GeneCards Summary for SGTB Gene

SGTB (Small Glutamine Rich Tetratricopeptide Repeat Containing Beta) is a Protein Coding gene. An important paralog of this gene is SGTA.

UniProtKB/Swiss-Prot for SGTB Gene

  • Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGTB Gene

Genomics for SGTB Gene

Regulatory Elements for SGTB Gene

Enhancers for SGTB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SGTB on UCSC Golden Path with GeneCards custom track

Promoters for SGTB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SGTB Gene

65,665,928 bp from pter
65,723,035 bp from pter
57,108 bases
Minus strand

Genomic View for SGTB Gene

Genes around SGTB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGTB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGTB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGTB Gene

Proteins for SGTB Gene

  • Protein details for SGTB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small glutamine-rich tetratricopeptide repeat-containing protein beta
    Protein Accession:

    Protein attributes for SGTB Gene

    304 amino acids
    Molecular mass:
    33429 Da
    Quaternary structure:
    • Homooligomerize.

neXtProt entry for SGTB Gene

Post-translational modifications for SGTB Gene

  • Ubiquitination at Lys 5
  • Modification sites at PhosphoSitePlus

Other Protein References for SGTB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SGTB Gene

Domains & Families for SGTB Gene

Gene Families for SGTB Gene

Protein Domains for SGTB Gene

Suggested Antigen Peptide Sequences for SGTB Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SGT family.
  • Contains 4 TPR repeats.
  • Belongs to the SGT family.
  • Contains 4 TPR repeats.
genes like me logo Genes that share domains with SGTB: view

Function for SGTB Gene

Molecular function for SGTB Gene

UniProtKB/Swiss-Prot Function:
Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.

Gene Ontology (GO) - Molecular Function for SGTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with SGTB: view

Phenotypes for SGTB Gene

genes like me logo Genes that share phenotypes with SGTB: view

Animal Model Products

CRISPR Products

miRNA for SGTB Gene

miRTarBase miRNAs that target SGTB

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SGTB Gene

Localization for SGTB Gene

Subcellular locations from

Jensen Localization Image for SGTB Gene COMPARTMENTS Subcellular localization image for SGTB gene
Compartment Confidence
cytosol 2
mitochondrion 2
peroxisome 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SGTB Gene

Pathways & Interactions for SGTB Gene

SuperPathways for SGTB Gene

No Data Available

Gene Ontology (GO) - Biological Process for SGTB Gene


No data available for Pathways by source and SIGNOR curated interactions for SGTB Gene

Drugs & Compounds for SGTB Gene

No Compound Related Data Available

Transcripts for SGTB Gene

mRNA/cDNA for SGTB Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SGTB Gene

Small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SGTB Gene

No ASD Table

Relevant External Links for SGTB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SGTB Gene

mRNA expression in normal human tissues for SGTB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SGTB Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.3) and Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for SGTB Gene

This gene is overexpressed in Bone (50.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SGTB Gene

Protein tissue co-expression partners for SGTB Gene

NURSA nuclear receptor signaling pathways regulating expression of SGTB Gene:


SOURCE GeneReport for Unigene cluster for SGTB Gene:

genes like me logo Genes that share expression patterns with SGTB: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SGTB Gene

Orthologs for SGTB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SGTB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SGTB 34
  • 94.3 (n)
  • 97.37 (a)
  • 97 (a)
(Canis familiaris)
Mammalia SGTB 34
  • 94.19 (n)
  • 98.03 (a)
  • 98 (a)
(Mus musculus)
Mammalia Sgtb 34
  • 87.72 (n)
  • 96.38 (a)
Sgtb 16
Sgtb 35
  • 96 (a)
(Pan troglodytes)
Mammalia SGTB 34
  • 99.67 (n)
  • 99.67 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Sgtb 34
  • 88.27 (n)
  • 96.05 (a)
(Monodelphis domestica)
Mammalia SGTB 35
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 79 (a)
-- 35
  • 51 (a)
(Gallus gallus)
Aves SGTB 34
  • 80.37 (n)
  • 85.86 (a)
  • 86 (a)
(Anolis carolinensis)
Reptilia SGTB 35
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sgtb 34
  • 70.39 (n)
  • 74.01 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13292 34
(Danio rerio)
Actinopterygii sgta 34
  • 68.53 (n)
  • 73.68 (a)
sgtb 35
  • 70 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003052 34
  • 49.94 (n)
  • 42.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sgt 34
  • 49.79 (n)
  • 39.15 (a)
Sgt 35
  • 29 (a)
(Caenorhabditis elegans)
Secernentea sgt-1 35
  • 34 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR005W 34
  • 48.6 (n)
  • 36.55 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D01155g 34
  • 48.15 (n)
  • 39.46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGT2 34
  • 47.35 (n)
  • 37.5 (a)
SGT2 35
  • 28 (a)
TAH1 37
bread mold
(Neurospora crassa)
Ascomycetes NCU10273 34
  • 43.54 (n)
  • 37.6 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1142.02c 34
  • 50.26 (n)
  • 39.45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10634 35
  • 38 (a)
Species where no ortholog for SGTB was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SGTB Gene

Gene Tree for SGTB (if available)
Gene Tree for SGTB (if available)

Paralogs for SGTB Gene

Paralogs for SGTB Gene

(5) SIMAP similar genes for SGTB Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SGTB: view

Variants for SGTB Gene

Sequence variations from dbSNP and Humsavar for SGTB Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs164643 -- 65,684,845(+) accac(A/G)cccag intron-variant
rs164644 -- 65,685,071(+) agcga(A/G)tggaa intron-variant
rs166320 -- 65,694,616(+) gaata(C/T)aggtg intron-variant
rs168458 -- 65,712,019(+) CAAGG(C/T)AGGAC intron-variant
rs189686 -- 65,668,201(+) ccctg(C/G)cttgg utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SGTB Gene

Variant ID Type Subtype PubMed ID
esv3367273 CNV insertion 20981092
esv3894204 CNV loss 25118596
nsv517021 CNV loss 19592680

Variation tolerance for SGTB Gene

Residual Variation Intolerance Score: 43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SGTB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SGTB Gene

Disorders for SGTB Gene

Relevant External Links for SGTB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SGTB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SGTB Gene

Publications for SGTB Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 65

Products for SGTB Gene

Sources for SGTB Gene

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