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Aliases for SGTB Gene

Aliases for SGTB Gene

  • Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, Beta 2 3
  • Small Glutamine-Rich Protein With Tetratricopeptide Repeats 2 3 4
  • Beta-SGT 3 4
  • SGT2 3 4
  • Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Beta 3
  • Small Glutamine Rich Protein With Tetratricopeptide Repeats 2 3

External Ids for SGTB Gene

Summaries for SGTB Gene

GeneCards Summary for SGTB Gene

SGTB (Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, Beta) is a Protein Coding gene. An important paralog of this gene is TTC12.

UniProtKB/Swiss-Prot for SGTB Gene

  • Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGTB Gene

Genomics for SGTB Gene

Genomic Location for SGTB Gene

Start:
65,665,928 bp from pter
End:
65,723,035 bp from pter
Size:
57,108 bases
Orientation:
Minus strand

Genomic View for SGTB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SGTB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGTB Gene

Regulatory Elements for SGTB Gene

Proteins for SGTB Gene

  • Protein details for SGTB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EQ0-SGTB_HUMAN
    Recommended name:
    Small glutamine-rich tetratricopeptide repeat-containing protein beta
    Protein Accession:
    Q96EQ0
    Secondary Accessions:

    Protein attributes for SGTB Gene

    Size:
    304 amino acids
    Molecular mass:
    33429 Da
    Quaternary structure:
    • Homooligomerize.

neXtProt entry for SGTB Gene

Proteomics data for SGTB Gene at MOPED

Post-translational modifications for SGTB Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys5

Other Protein References for SGTB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SGTB Gene

Domains for SGTB Gene

Gene Families for SGTB Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for SGTB Gene

UniProtKB/Swiss-Prot:

SGTB_HUMAN
Family:
  • Belongs to the SGT family.:
    • Q96EQ0
Similarity:
  • Contains 4 TPR repeats.:
    • Q96EQ0
genes like me logo Genes that share domains with SGTB: view

Function for SGTB Gene

Molecular function for SGTB Gene

UniProtKB/Swiss-Prot Function: Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.

Gene Ontology (GO) - Molecular Function for SGTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with SGTB: view

miRNA for SGTB Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SGTB Gene

Localization for SGTB Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SGTB Gene COMPARTMENTS Subcellular localization image for SGTB gene
Compartment Confidence
cytosol 2
mitochondrion 2
peroxisome 2
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for SGTB Gene

Pathways for SGTB Gene

SuperPathways for SGTB Gene

No Data Available

Gene Ontology (GO) - Biological Process for SGTB Gene

None

No data available for Pathways by source for SGTB Gene

Transcripts for SGTB Gene

mRNA/cDNA for SGTB Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SGTB Gene

Small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SGTB Gene

No ASD Table

Relevant External Links for SGTB Gene

GeneLoc Exon Structure for
SGTB
ECgene alternative splicing isoforms for
SGTB

Expression for SGTB Gene

mRNA expression in normal human tissues for SGTB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SGTB Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (4.3) and Whole Blood (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SGTB Gene

SOURCE GeneReport for Unigene cluster for SGTB Gene Hs.482301

genes like me logo Genes that share expressions with SGTB: view

Orthologs for SGTB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SGTB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SGTB 36
  • 99.67 (n)
  • 99.67 (a)
SGTB 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SGTB 36
  • 94.3 (n)
  • 97.37 (a)
SGTB 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SGTB 36
  • 94.19 (n)
  • 98.03 (a)
SGTB 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sgtb 36
  • 87.72 (n)
  • 96.38 (a)
Sgtb 16
Sgtb 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SGTB 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 79 (a)
OneToMany
-- 37
  • 51 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Sgtb 36
  • 88.27 (n)
  • 96.05 (a)
chicken
(Gallus gallus)
Aves SGTB 36
  • 80.37 (n)
  • 85.86 (a)
SGTB 37
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SGTB 37
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13292 36
tropical clawed frog
(Silurana tropicalis)
Amphibia sgtb 36
  • 70.39 (n)
  • 74.01 (a)
zebrafish
(Danio rerio)
Actinopterygii sgta 36
  • 68.53 (n)
  • 73.68 (a)
sgtb 37
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003052 36
  • 49.94 (n)
  • 42.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sgt 36
  • 49.79 (n)
  • 39.15 (a)
Sgt 37
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sgt-1 37
  • 34 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR005W 36
  • 48.6 (n)
  • 36.55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGT2 36
  • 47.35 (n)
  • 37.5 (a)
SGT2 37
  • 28 (a)
OneToMany
TAH1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D01155g 36
  • 48.15 (n)
  • 39.46 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU10273 36
  • 43.54 (n)
  • 37.6 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1142.02c 36
  • 50.26 (n)
  • 39.45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10634 37
  • 38 (a)
OneToMany
Species with no ortholog for SGTB:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SGTB Gene

ENSEMBL:
Gene Tree for SGTB (if available)
TreeFam:
Gene Tree for SGTB (if available)

Paralogs for SGTB Gene

Paralogs for SGTB Gene

Selected SIMAP similar genes for SGTB Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SGTB: view

Variants for SGTB Gene

Sequence variations from dbSNP and Humsavar for SGTB Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs27136 -- 65,670,922(+) ATAAA(A/G)TGTCC intron-variant
rs27137 -- 65,670,691(+) TATAC(C/G)CAAGT intron-variant
rs27138 -- 65,669,310(+) GCACA(C/G)AATTA utr-variant-3-prime
rs27149 -- 65,701,974(+) tagtt(C/T)ctcaa intron-variant
rs27394 -- 65,669,930(-) CAAAG(C/T)ATATT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SGTB Gene

Variant ID Type Subtype PubMed ID
nsv517021 CNV Loss 19592680

Relevant External Links for SGTB Gene

HapMap Linkage Disequilibrium report
SGTB

Disorders for SGTB Gene

No disorders were found for SGTB Gene.

No data available for UniProtKB/Swiss-Prot for SGTB Gene

Publications for SGTB Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for SGTB Gene

Sources for SGTB Gene

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