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SGTA Gene

protein-coding   GIFtS: 57
GCID: GC19M002754

Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing,...

(Previous name: small glutamine-rich tetratricopeptide repeat (TPR)-containing)
(Previous symbol: SGT)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing,
Alpha1 2
     alphaSGT2
SGT1 2 3 5     hSGT2
Vpu-Binding Protein2 3     Protein Containing Three Tetratricopeptide Repeats2
UBP2 3     Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha2
Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing1     Alpha-SGT3
alpha-SGT2     SGT13

External Ids:    HGNC: 108191   Entrez Gene: 64492   Ensembl: ENSG000001049697   OMIM: 6034195   UniProtKB: O437653   

Export aliases for SGTA gene to outside databases

Previous GC identifers: GC19M002705 GC19M002525


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SGTA Gene:
This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1
and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed
ubiquitously in various tissues, this protein may serve a housekeeping function. (provided by RefSeq, Jul 2008)

GeneCards Summary for SGTA Gene:
SGTA (small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha) is a protein-coding gene. Diseases associated with SGTA include pontiac fever, and clear cell hidradenoma. An important paralog of this gene is RPAP3.

UniProtKB/Swiss-Prot: SGTA_HUMAN, O43765
Function: Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity

Gene Wiki entry for SGTA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the SGTA gene promoter:
         CREB   SRY   deltaCREB   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSGTA promoter sequence
   Search Chromatin IP Primers for SGTA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SGTA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13

SGTA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SGTA gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M002754:  view genomic region     (about GC identifiers)

Start:
2,754,712 bp from pter      End:
2,783,369 bp from pter
Size:
28,658 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SGTA_HUMAN, O43765 (See protein sequence)
Recommended Name: Small glutamine-rich tetratricopeptide repeat-containing protein alpha  
Size: 313 amino acids; 34063 Da
Subunit: Homooligomerize (By similarity). Interacts with NS1 from parvovirus H-1, with Vpu and Gag from HIV-1.
Interacts with SARS-CoV accessory protein 7a. Interacts with DNAJC5 and DNAJC5B
4 PDB 3D structures from and Proteopedia for SGTA:
2VYI (3D)        4GOD (3D)        4GOE (3D)        4GOF (3D)    
Secondary accessions: D6W610 Q6FIA9 Q9BTZ9

Explore the universe of human proteins at neXtProt for SGTA: NX_O43765

Explore proteomics data for SGTA at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys103, Lys116, Lys137, Lys160, Lys174, Lys183, Lys184, Lys200
  • Modification sites at PhosphoSitePlus

  • See SGTA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003012.1  
    ENSEMBL proteins: 
     ENSP00000221566   ENSP00000466461   ENSP00000468443  

    SGTA Human Recombinant Protein Products:

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    Novus Biologicals SGTA Proteins
    Novus Biologicals SGTA Lysates
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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SGTA
    Browse Proteins at Cloud-Clone Corp.

    SGTA Antibody Products:

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    Abcam antibodies for SGTA (O43765, Q6FIA9)
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    LSBio Antibodies in human, mouse, rat for SGTA

    SGTA Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TTC: Tetratricopeptide (TTC) repeat domain containing

    4 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR001440 TPR_1
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry O43765

    ProtoNet protein and cluster: O43765

    UniProtKB/Swiss-Prot: SGTA_HUMAN, O43765
    Domain: The second tetratricopeptide repeat (TPR 2) mediates the interaction with SARS-CoV accessory protein 7a
    Similarity: Belongs to the SGT family
    Similarity: Contains 3 TPR repeats


    SGTA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SGTA_HUMAN, O43765
    Function: Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    SGTA for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for SGTA:
     Decreased TP53 protein express  G0/1 arrest  Increased G1 DNA content 

         1 MGI phenotypic allele for Sgta (no phenotypes)

    SGTA for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SGTA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SGTA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SGTA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SGTA

    miRNA
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    miRTarBase miRNAs that target SGTA:
    hsa-mir-16-5p (MIRT031542), hsa-mir-221-3p (MIRT046945), hsa-mir-30d-5p (MIRT047826)

    Block miRNA regulation of human, mouse, rat SGTA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SGTA (see all 12):
    hsa-miR-3938 hsa-miR-4286 hsa-miR-224 hsa-miR-34c-5p hsa-miR-449b hsa-miR-657 hsa-miR-449a hsa-miR-2355-5p
    SwitchGear 3'UTR luciferase reporter plasmidSGTA 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SGTA
    Predesigned siRNA for gene silencing in human, mouse, rat SGTA

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SGTA (NM_003021)
    Sino Biological Human cDNA Clone for SGTA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SGTA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGTA

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGTA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--

    SGTA for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SGTA About    
    See pathways by source

    SuperPathContained pathways About
    1Protein Stability
    Protein Stability

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SGTA
        Protein Stability




    SGTA for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SGTA
    Interactions:

        GeneGlobe Interaction Network for SGTA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SGTA (O437651, 2, 3 ENSP000002215664) via UniProtKB, MINT, STRING, and/or I2D (see all 183)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAG6P463792, 3, ENSP000003651314MINT-62791 MINT-62617 MINT-62715 I2D: score=4 STRING: ENSP00000365131
    ENSG00000096155P463792, 3MINT-62791 MINT-62617 MINT-62715 I2D: score=4 
    ENSG00000227761P463792, 3MINT-62791 MINT-62617 MINT-62715 I2D: score=4 
    ENSG00000228760P463792, 3MINT-62791 MINT-62617 MINT-62715 I2D: score=4 
    ENSG00000229524P463792, 3MINT-62791 MINT-62617 MINT-62715 I2D: score=4 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----

    SGTA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SGTA

    1 Novoseek inferred chemical compound relationship for SGTA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 14.5 1 12878599 (1)



    SGTA for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SGTA gene: 
    NM_003021.3  

    Unigene Cluster for SGTA:

    Small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
    Hs.203910  [show with all ESTs]
    Unigene Representative Sequence: NM_003021
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000221566(uc002lwi.1) ENST00000591984 ENST00000589251 ENST00000587866
    ENST00000586711
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SGTA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SGTA (see all 12):
    hsa-miR-3938 hsa-miR-4286 hsa-miR-224 hsa-miR-34c-5p hsa-miR-449b hsa-miR-657 hsa-miR-449a hsa-miR-2355-5p
    SwitchGear 3'UTR luciferase reporter plasmidSGTA 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SGTA
    Predesigned siRNA for gene silencing in human, mouse, rat SGTA
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SGTA (NM_003021)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SGTA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGTA
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SGTA
    OriGene qSTAR qPCR primer pairs in human, mouse for SGTA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SGTA
      QuantiTect SYBR Green Assays in human, mouse, rat SGTA
      QuantiFast Probe-based Assays in human, mouse, rat SGTA

    Additional mRNA sequence: 

    AF368279.1 AF408399.1 AJ133129.1 AJ223828.1 AK293535.1 AL050156.1 BC000390.2 BC002989.1 
    BC005165.2 BC008885.2 CR533517.1 CR542282.1 

    12 DOTS entries:

    DT.317478  DT.100797852  DT.97773186  DT.92057255  DT.95258316  DT.100797866  DT.101984599  DT.121498766 
    DT.95104945  DT.95258319  DT.102825160  DT.97773258 

    Selected AceView cDNA sequences (see all 510):

    BM793982 BE265518 BG818395 CF132156 BU150605 AI683956 AA304925 BM670564 
    CR619830 BG576695 AL558139 BM991278 BE382524 BP870816 BU553544 BU625039 
    BM018388 BM724989 CR603333 BC002989 CR542282 AW651652 BQ061763 BM710451 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SGTA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGGTGAGGT
    SGTA Expression
    About this image

    SGTA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SGTA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.203910

    UniProtKB/Swiss-Prot: SGTA_HUMAN, O43765
    Tissue specificity: Ubiquitous

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    QuantiFast Probe-based Assays in human, mouse, rat SGTA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGTA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SGTA gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sgta1 , 5 small glutamine-rich tetratricopeptide repeat (TPR)-containing, more1, 5 82.96(n)1
    88.82(a)1
      10 (39.72 cM)5
    525511  NM_024499.11  NP_078775.11 
     810440735 
    chicken
    (Gallus gallus)
    Aves SGTA1 small glutamine-rich tetratricopeptide repeat (TPR)-containing, more 74.06(n)
    81.67(a)
      426396  NM_001031379.1  NP_001026550.1 
    lizard
    (Anolis carolinensis)
    Reptilia SGTA6
    small glutamine-rich tetratricopeptide repeat (TPR...
    77(a)
    1 ↔ 1
    AAWZ02039698(58-5389)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC3949942 hypothetical protein LOC394994 74.55(n)    BC064275.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC048062.12   -- 74.8(n)    BC048062.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sgt6
    small glutamine-rich tetratricopeptide containing ...
    30(a)
    1 → many
    2L(17471603-17474773)
    worm
    (Caenorhabditis elegans)
    Secernentea sgt-11 sgt-1 50.72(n)
    46.76(a)
      173846  NM_062492.5  NP_494893.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SGT2(YOR007C)4 Glutamine-rich cytoplasmic protein that serves as a more   --   15(339978-338938) 854168  NP_014649.1 


    ENSEMBL Gene Tree for SGTA (if available)
    TreeFam Gene Tree for SGTA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SGTA gene
    RPAP32  SGTB2  TTC122  
    2 SIMAP similar genes for SGTA using alignment to 3 protein entries:     SGTA_HUMAN (see all proteins):
    H_YN88E09.1    SGTB

    SGTA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SGTA (see all 895)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1817268721,2
    --2754219(+) CTCGTC/TTCTAC 1 -- ds50010--------
    rs1130528821,2
    C,F--2754227(+) TACTAC/AAAATA 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1407830411,2
    C--2754250(+) TGGGCA/GTGGTG 1 -- ds50010--------
    rs1131592691,2
    C,F--2754287(+) GGAAGG/ACTGAC 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1457751221,2
    --2754313(+) GAACCC/TGGGAG 1 -- ds50010--------
    rs126114031,2
    C,F,H--2754326(+) ggaggT/Ctgagg 1 -- ds50014Minor allele frequency- C:0.38NA WA 8
    rs1436772831,2
    C--2754337(+) TGAGCC/TGAGAT 1 -- ds50010--------
    rs3744114081,2
    C--2754401(+) AAAAA-/GCAAA 
     GCAAAGC
    AACAG
    1 -- ds50010--------
    rs573166621,2
    C,F--2754479(+) CCTCTA/GCACCG 1 -- ds50011Minor allele frequency- G:0.16WA 118
    rs568802951,2
    C,F--2754482(+) CTACAC/TCGGGA 1 -- ds50011Minor allele frequency- T:0.16WA 118

    HapMap Linkage Disequilibrium report for SGTA (2754712 - 2783369 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SGTA (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2363232CNV Deletion18987734
    esv2605105CNV Deletion19546169
    esv1158443CNV Deletion17803354
    esv1403577CNV Deletion17803354
    nsv509714CNV Insertion20534489
    nsv910691CNV Loss21882294
    nsv910693CNV Loss21882294
    nsv910692CNV Loss21882294
    dgv3642n71CNV Loss21882294
    dgv3641n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SGTA
    DNA2.0 Custom Variant and Variant Library Synthesis for SGTA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603419    OMIM disorders: --

    14 diseases for SGTA:    
    About MalaCards
    pontiac fever    clear cell hidradenoma    hidrocystoma    spiradenoma
    syringocystadenoma papilliferum    hidradenoma    tracheal stenosis    syringoma
    severe acute respiratory syndrome    mucoepidermoid carcinoma    polycystic ovary syndrome    hiv-1
    prostate cancer    prostatitis

    3 diseases from the University of Copenhagen DISEASES database for SGTA:
    Pontiac fever     Hidrocystoma     Clear cell hidradenoma

    SGTA for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for SGTA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 6.69 2 14570907 (1), 12878599 (1)

    Genetic Association Database (GAD): SGTA
    Human Genome Epidemiology (HuGE) Navigator: SGTA (2 documents)

    Export disorders for SGTA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SGTA gene, integrated from 10 sources (see all 79):
    (articles sorted by number of sources associating them with SGTA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of human SGT and identification of homologues in Saccharomyces cerevisiae and Caenorhabditis elegans. (PubMed id 9740675)1, 2, 3, 9 Kordes E....Cziepluch C. (Genomics 1998)
    2. Structural and functional characterization of human SGT and its interaction with Vpu of the human immunodeficiency virus type 1. (PubMed id 18759457)1, 2, 9 Dutta S. and Tan Y.J. (Biochemistry 2008)
    3. Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA), a candidate gene for polycystic ovary syndrome. (PubMed id 18332089)1, 4, 9 Goodarzi M.O....Azziz R. (Hum. Reprod. 2008)
    4. Small glutamine-rich tetratricopeptide repeat-containing protein (SGT) interacts with the ubiquitin-dependent endocytosis (UbE) motif of the growth hormone receptor. (PubMed id 12735788)1, 3, 9 Schantl J.A....Strous G.J. (Biochem. J. 2003)
    5. Functional interaction of human immunodeficiency virus type 1 Vpu and Gag with a novel member of the tetratricopeptide repeat protein family. (PubMed id 9573291)1, 2, 9 Callahan M.A....Panganiban A.T. (J. Virol. 1998)
    6. Family-based analysis of candidate genes for polycystic ovary syndrome. (PubMed id 20200332)1, 4 Ewens K.G....Spielman R.S. (J. Clin. Endocrinol. Metab. 2010)
    7. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    8. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6449 HGNC: 10819 AceView: SGTA Ensembl:ENSG00000104969 euGenes: HUgn6449
    ECgene: SGTA H-InvDB: SGTA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SGTA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SGTA gene:
    Search GeneIP for patents involving SGTA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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