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Aliases for SGTA Gene

Aliases for SGTA Gene

  • Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, Alpha 2 3
  • SGT 3 4 6
  • Vpu-Binding Protein 3 4
  • Alpha-SGT 3 4
  • UBP 3 4
  • Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha 3
  • Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing 2
  • Protein Containing Three Tetratricopeptide Repeats 3
  • AlphaSGT 3
  • SGT1 4
  • HSGT 3

External Ids for SGTA Gene

Previous HGNC Symbols for SGTA Gene

  • SGT

Previous GeneCards Identifiers for SGTA Gene

  • GC19M002705
  • GC19M002525

Summaries for SGTA Gene

Entrez Gene Summary for SGTA Gene

  • This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function. [provided by RefSeq, Jul 2008]

GeneCards Summary for SGTA Gene

SGTA (Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, Alpha) is a Protein Coding gene. Diseases associated with SGTA include clear cell hidradenoma and pontiac fever. Among its related pathways are Protein Stability. An important paralog of this gene is TTC12.

UniProtKB/Swiss-Prot for SGTA Gene

  • Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.

Gene Wiki entry for SGTA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGTA Gene

Genomics for SGTA Gene

Regulatory Elements for SGTA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SGTA Gene

Start:
2,754,714 bp from pter
End:
2,783,371 bp from pter
Size:
28,658 bases
Orientation:
Minus strand

Genomic View for SGTA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SGTA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGTA Gene

Proteins for SGTA Gene

  • Protein details for SGTA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43765-SGTA_HUMAN
    Recommended name:
    Small glutamine-rich tetratricopeptide repeat-containing protein alpha
    Protein Accession:
    O43765
    Secondary Accessions:
    • D6W610
    • Q6FIA9
    • Q9BTZ9

    Protein attributes for SGTA Gene

    Size:
    313 amino acids
    Molecular mass:
    34063 Da
    Quaternary structure:
    • Homooligomerize (By similarity). Interacts with NS1 from parvovirus H-1, with Vpu and Gag from HIV-1. Interacts with SARS-CoV accessory protein 7a. Interacts with DNAJC5 and DNAJC5B.

    Three dimensional structures from OCA and Proteopedia for SGTA Gene

neXtProt entry for SGTA Gene

Proteomics data for SGTA Gene at MOPED

Post-translational modifications for SGTA Gene

  • Ubiquitination at Lys103, Lys116, Lys137, Lys160, Lys174, Lys183, Lys184, and Lys200
  • Modification sites at PhosphoSitePlus

Other Protein References for SGTA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SGTA (SGTA)

No data available for DME Specific Peptides for SGTA Gene

Domains for SGTA Gene

Gene Families for SGTA Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for SGTA Gene

Suggested Antigen Peptide Sequences for SGTA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43765

UniProtKB/Swiss-Prot:

SGTA_HUMAN :
  • O43765
Domain:
  • The second tetratricopeptide repeat (TPR 2) mediates the interaction with SARS-CoV accessory protein 7a
Family:
  • Belongs to the SGT family.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with SGTA: view

Function for SGTA Gene

Molecular function for SGTA Gene

UniProtKB/Swiss-Prot Function: Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.

Gene Ontology (GO) - Molecular Function for SGTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14667819
genes like me logo Genes that share ontologies with SGTA: view
genes like me logo Genes that share phenotypes with SGTA: view

Animal Model Products

CRISPR Products

miRNA for SGTA Gene

miRTarBase miRNAs that target SGTA

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SGTA Gene

Localization for SGTA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SGTA Gene COMPARTMENTS Subcellular localization image for SGTA gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SGTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with SGTA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SGTA Gene

Pathways for SGTA Gene

SuperPathways for SGTA Gene

Superpath Contained pathways
1 Protein Stability
genes like me logo Genes that share pathways with SGTA: view

Pathways by source for SGTA Gene

1 Cell Signaling Technology pathway for SGTA Gene

Gene Ontology (GO) - Biological Process for SGTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with SGTA: view

Compounds for SGTA Gene

(1) Novoseek inferred chemical compound relationships for SGTA Gene

Compound -log(P) Hits PubMed IDs
cysteine 14.5 1
genes like me logo Genes that share compounds with SGTA: view

Transcripts for SGTA Gene

Unigene Clusters for SGTA Gene

Small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SGTA

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SGTA Gene

No ASD Table

Relevant External Links for SGTA Gene

GeneLoc Exon Structure for
SGTA
ECgene alternative splicing isoforms for
SGTA

Expression for SGTA Gene

mRNA expression in normal human tissues for SGTA Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SGTA Gene

SOURCE GeneReport for Unigene cluster for SGTA Gene Hs.203910

mRNA Expression by UniProt/SwissProt for SGTA Gene

O43765-SGTA_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with SGTA: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SGTA Gene

Orthologs for SGTA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SGTA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SGTA 35
  • 98.94 (n)
  • 100 (a)
SGTA 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SGTA 35
  • 88.39 (n)
  • 95.21 (a)
SGTA 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SGTA 35
  • 89.78 (n)
  • 95.85 (a)
SGTA 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sgta 35
  • 82.96 (n)
  • 88.82 (a)
Sgta 16
Sgta 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 66 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SGTA 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sgta 35
  • 83.92 (n)
  • 88.82 (a)
chicken
(Gallus gallus)
Aves SGTA 35
  • 74.06 (n)
  • 81.67 (a)
SGTA 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SGTA 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC394994 35
sgta 35
  • 68.49 (n)
  • 75.81 (a)
zebrafish
(Danio rerio)
Actinopterygii sgta 36
  • 69 (a)
OneToMany
SGTA (1 of 2) 36
  • 67 (a)
OneToMany
zgc:55741 35
  • 66.56 (n)
  • 70.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sgt 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sgt-1 35
  • 50.72 (n)
  • 46.76 (a)
sgt-1 36
  • 37 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGT2 36
  • 31 (a)
OneToMany
SGT2 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10634 36
  • 40 (a)
OneToMany
Species with no ortholog for SGTA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SGTA Gene

ENSEMBL:
Gene Tree for SGTA (if available)
TreeFam:
Gene Tree for SGTA (if available)

Paralogs for SGTA Gene

Paralogs for SGTA Gene

Selected SIMAP similar genes for SGTA Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SGTA: view

Variants for SGTA Gene

Sequence variations from dbSNP and Humsavar for SGTA Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs7008 -- 2,754,980(-) ACAGC(A/G)GGCAG utr-variant-3-prime
rs7009 -- 2,754,794(-) AGCCG(C/T)TCATG utr-variant-3-prime
rs13282 -- 2,754,812(-) GGGCC(A/C/G)CCGCG utr-variant-3-prime
rs741103 -- 2,771,643(-) CACGT(A/G)CCTGC intron-variant
rs741104 -- 2,771,690(-) CCTCA(C/G)CATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SGTA Gene

Variant ID Type Subtype PubMed ID
nsv509714 CNV Insertion 20534489
nsv910675 CNV Loss 21882294
dgv3641n71 CNV Loss 21882294
nsv910678 CNV Loss 21882294
nsv828397 CNV Gain 20364138
dgv3642n71 CNV Loss 21882294
dgv3643n71 CNV Loss 21882294
nsv910691 CNV Loss 21882294
nsv910692 CNV Loss 21882294
esv2605105 CNV Deletion 19546169
esv2363232 CNV Deletion 18987734
esv29323 CNV Loss 19812545
esv1403577 CNV Deletion 17803354
esv1158443 CNV Deletion 17803354
nsv910693 CNV Loss 21882294

Relevant External Links for SGTA Gene

HapMap Linkage Disequilibrium report
SGTA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SGTA Gene

Disorders for SGTA Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for SGTA Gene including...

Search for SGTA Gene in MalaCards »

(3) University of Copenhagen DISEASES for SGTA Gene

(1) Novoseek inferred disease relationships for SGTA Gene

Disease -log(P) Hits PubMed IDs
shock 6.69 2

Relevant External Links for SGTA

Genetic Association Database (GAD)
SGTA
Human Genome Epidemiology (HuGE) Navigator
SGTA
genes like me logo Genes that share disorders with SGTA: view

No data available for UniProtKB/Swiss-Prot for SGTA Gene

Publications for SGTA Gene

  1. Isolation and characterization of human SGT and identification of homologues in Saccharomyces cerevisiae and Caenorhabditis elegans. (PMID: 9740675) Kordes E. … Cziepluch C. (Genomics 1998) 2 3 4 23
  2. Functional interaction of human immunodeficiency virus type 1 Vpu and Gag with a novel member of the tetratricopeptide repeat protein family. (PMID: 9573291) Callahan M.A. … Panganiban A.T. (J. Virol. 1998) 3 4 23
  3. Small glutamine-rich tetratricopeptide repeat-containing protein (SGT) interacts with the ubiquitin-dependent endocytosis (UbE) motif of the growth hormone receptor. (PMID: 12735788) Schantl J.A. … Strous G.J. (Biochem. J. 2003) 2 3 23
  4. Structural and functional characterization of human SGT and its interaction with Vpu of the human immunodeficiency virus type 1. (PMID: 18759457) Dutta S. … Tan Y.J. (Biochemistry 2008) 3 4 23
  5. Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA), a candidate gene for polycystic ovary syndrome. (PMID: 18332089) Goodarzi M.O. … Azziz R. (Hum. Reprod. 2008) 3 23 48

Products for SGTA Gene

Sources for SGTA Gene

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