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SGSM3 Gene

protein-coding   GIFtS: 54
GCID: GC22P040766

Small G Protein Signaling Modulator 3

(Previous name: RUN and TBC1 domain containing 3)
(Previous symbol: RUTBC3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Small G Protein Signaling Modulator 31 2     RUSC32 5
RUTBC31 2 3 5     RABGAP52
MAP2 3 5     RabGAP-52
RUN And TBC1 Domain Containing 31 2     Merlin Binding Protein2
RUN And SH3 Containing 31 2     rabGAPLP2
Merlin-Associated Protein2 3     Small G Protein Signaling Modulator 3 Protein2
Rab-GTPase-Activating Protein-Like Protein2 3     RABGAPLP3
RUN And TBC1 Domain-Containing Protein 32 3     RabGAPLP3

External Ids:    HGNC: 252281   Entrez Gene: 273522   Ensembl: ENSG000001003597   OMIM: 6104405   UniProtKB: Q96HU13   

Export aliases for SGSM3 gene to outside databases

Previous GC identifers: GC22P039096 GC22P023729


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SGSM3 Gene:
SGSM3 (small G protein signaling modulator 3) is a protein-coding gene. GO annotations related to this gene include Rab GTPase activator activity and Rab GTPase binding. An important paralog of this gene is TBC1D2.

UniProtKB/Swiss-Prot: SGSM3_HUMAN, Q96HU1
Function: May play a cooperative role in NF2-mediated growth suppression of cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SGSM3 gene promoter:
         AML1a   Pax-5   Tal-1   Pax-2   E47   IRF-7A   MRF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSGSM3 promoter sequence
   Search Chromatin IP Primers for SGSM3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SGSM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1-q13.2   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1-q13.2

SGSM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SGSM3 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P040766:  view genomic region     (about GC identifiers)

Start:
40,766,595 bp from pter      End:
40,806,293 bp from pter
Size:
39,699 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SGSM3_HUMAN, Q96HU1 (See protein sequence)
Recommended Name: Small G protein signaling modulator 3  
Size: 749 amino acids; 85354 Da
Subunit: Interacts with GJA1. Interaction with GJA1 induces its degradation (By similarity). Interacts via its RUN
domain with the C-terminal region of NF2. Interacts with RAB3A, RAB4A, RAB5A, RAB8A, RAB11A, RAP1A, RAP1B, RAP2A,
RAP2B and PDCD6IP. No interaction with RAB27A
Secondary accessions: B0QY79 Q7Z709 Q9NT69
Alternative splicing: 2 isoforms:  Q96HU1-1   Q96HU1-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for SGSM3: NX_Q96HU1

Explore proteomics data for SGSM3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys146, Lys542
  • Modification sites at PhosphoSitePlus

  • See SGSM3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056520.2  
    ENSEMBL proteins: 
     ENSP00000399249   ENSP00000248929   ENSP00000407286   ENSP00000415323   ENSP00000390998  

    SGSM3 Human Recombinant Protein Products:

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    Novus Biologicals SGSM3 Protein
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    Cloud-Clone Corp. Proteins for SGSM3

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SGSM: Small G protein signaling modulators

    3 InterPro protein domains:
     IPR000195 Rab-GTPase-TBC_dom
     IPR001452 SH3_domain
     IPR004012 Run

    Graphical View of Domain Structure for InterPro Entry Q96HU1

    ProtoNet protein and cluster: Q96HU1

    2 Blocks protein domains:
    IPB000195 RabGAP/TBC domain
    IPB001452 SH3 domain signature


    UniProtKB/Swiss-Prot: SGSM3_HUMAN, Q96HU1
    Similarity: Belongs to the small G protein signaling modulator family
    Similarity: Contains 1 Rab-GAP TBC domain
    Similarity: Contains 1 RUN domain
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with SGSM3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SGSM3_HUMAN, Q96HU1
    Function: May play a cooperative role in NF2-mediated growth suppression of cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005097Rab GTPase activator activity IEA--
    GO:0005515protein binding IPI17509819
    GO:0017137Rab GTPase binding IDA17509819
         
    Find genes that share ontologies with SGSM3           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SGSM3
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    miRNA
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    miRTarBase miRNAs that target SGSM3:
    hsa-mir-124-3p (MIRT022600), hsa-let-7e-5p (MIRT051662)

    Block miRNA regulation of human, mouse, rat SGSM3 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate SGSM3:
    hsa-miR-4324 hsa-miR-544b hsa-miR-378*
    SwitchGear 3'UTR luciferase reporter plasmidSGSM3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SGSM3

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGSM3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGSM3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SGSM3_HUMAN, Q96HU1: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus3
    cytosol2
    nucleus2
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005921gap junction IEA--

    Find genes that share ontologies with SGSM3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SGSM3
    Interactions:

        Search GeneGlobe Interaction Network for SGSM3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for SGSM3 (Q96HU12, 3 ENSP000002489294) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL35P427662, 3, ENSP000002594694MINT-8269043 I2D: score=2 STRING: ENSP00000259469
    GJA1P173023, ENSP000002825614I2D: score=2 STRING: ENSP00000282561
    NF2P352403, ENSP000003446664I2D: score=3 STRING: ENSP00000344666
    PDCD6IPENSP000003073874STRING: ENSP00000307387
    COG4ENSP000003157754STRING: ENSP00000315775
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007050cell cycle arrest IEA--
    GO:0032313regulation of Rab GTPase activity ----
    GO:0032483regulation of Rab protein signal transduction IEP17509819
    GO:0032486Rap protein signal transduction IEP17509819
    GO:0045732positive regulation of protein catabolic process IEA--

    Find genes that share ontologies with SGSM3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SGSM3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SGSM3 gene: 
    NM_015705.4  

    Unigene Cluster for SGSM3:

    Small G protein signaling modulator 3
    Hs.474914  [show with all ESTs]
    Unigene Representative Sequence: NM_015705
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000457767 ENST00000248929(uc010gyc.1 uc003ayu.1 uc011aot.1)
    ENST00000485962 ENST00000478085 ENST00000480830 ENST00000481408 ENST00000481028
    ENST00000470518 ENST00000467915 ENST00000427834 ENST00000469719 ENST00000462457
    ENST00000417424 ENST00000454798(uc011aos.1)
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate SGSM3:
    hsa-miR-4324 hsa-miR-544b hsa-miR-378*
    SwitchGear 3'UTR luciferase reporter plasmidSGSM3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SGSM3
    Predesigned siRNA for gene silencing in human, mouse, rat SGSM3
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SGSM3 (NM_015705)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SGSM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGSM3
    Primer
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    OriGene qPCR primer pairs and template standards for SGSM3
    OriGene qSTAR qPCR primer pairs in human, mouse for SGSM3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SGSM3
      QuantiTect SYBR Green Assays in human, mouse, rat SGSM3
      QuantiFast Probe-based Assays in human, mouse, rat SGSM3

    Additional mRNA sequence: 

    AB196956.1 AB275763.1 AB449880.1 AK295469.1 AK297599.1 AK301042.1 AK309400.1 AL137499.1 
    AY308849.1 BC008078.2 BC127850.1 CR456441.1 

    Selected DOTS entries (see all 37):

    DT.80100307  DT.101955159  DT.95291825  DT.91825124  DT.100640800  DT.95264350  DT.100642923  DT.100842687 
    DT.92438765  DT.100774457  DT.100639779  DT.100662984  DT.120648950  DT.92438759  DT.100643652  DT.100662978 
    DT.100662980  DT.95264338  DT.95264344  DT.99971117  DT.100661166  DT.100662977  DT.100865790  DT.120649003 

    Selected AceView cDNA sequences (see all 228):

    AA581796 BE855918 BQ927764 BX333866 BX449364 BM703668 BU845892 BX424691 
    CR608708 AA732831 BE882434 BG420165 BP351145 BX336978 CR456441 NM_015705 
    BU730100 BM547676 AL137499 BP354984 BX407253 AI292006 CD108034 BQ057147 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SGSM3 (see all 17)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^
    SP1:                                -                                                                                   -                                       
    SP2:                                                                                                                                                            
    SP3:                    -           -                                                                                                                           
    SP4:                                -                                                                                                                           
    SP5:                                                                                                                                                            

    ExUns: 17 ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b · 20c ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b · 24c · 24d · 24e
    SP1:                                                                                                      
    SP2:                                                                                                      
    SP3:                                                                                                      
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for SGSM3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SGSM3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGTGCTCA
    SGSM3 Expression
    About this image


    SGSM3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
     
     Colon (Gastrointestinal Tract)
     
     Gall Bladder (Hepatobiliary System)
     
     Stomach (Gastrointestinal Tract)
     
     Spleen (Hematopoietic System)
    SGSM3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SGSM3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.474914

    UniProtKB/Swiss-Prot: SGSM3_HUMAN, Q96HU1
    Tissue specificity: Widely expressed

        Custom PCR Arrays for SGSM3
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    QuantiFast Probe-based Assays in human, mouse, rat SGSM3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGSM3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SGSM3 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sgsm31 , 5 small G protein signaling modulator 31, 5 88.59(n)1
    94.12(a)1
      15 (37.96 cM)5
    1058351  NM_134091.21  NP_598852.21 
     809777655 
    chicken
    (Gallus gallus)
    Aves SGSM31 small G protein signaling modulator 3 81.02(n)
    88.08(a)
      418008  XM_004937716.1  XP_004937773.1 
    lizard
    (Anolis carolinensis)
    Reptilia SGSM36
    small G protein signaling modulator 3
    87(a)
    1 ↔ 1
    5(25788453-25829812)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.150192 Xenopus laevis transcribed sequence with moderate similarity more 81.33(n)    CD100131.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa11c022 Danio rerio cDNA clone MGC64026 IMAGE6793215, complete more 78.98(n)    BC054597.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG122411 CG12241 65.72(n)
    66.26(a)
      41834  NM_142175.3  NP_650432.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tbc-181 tbc-18 49.63(n)
    46.01(a)
      181091  NM_077020.4  NP_509421.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MDR16
    Cytoplasmic GTPase-activating protein for Ypt/Rab ...
    13(a)
    1 → many
    VII(690245-693097) YGR100W


    ENSEMBL Gene Tree for SGSM3 (if available)
    TreeFam Gene Tree for SGSM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SGSM3 gene
    TBC1D22  TBC1D8B2  TBC1D302  TBC1D2B2  TBC1D9B2  TBC1D82  TBC1D92  
    Selected SIMAP similar genes for SGSM3 using alignment to 6 protein entries:     SGSM3_HUMAN (see all proteins) (see all similar genes):
    FLJ00006    RUTBC3    SH3GL1    SH3GL2    ARHGEF7    TBC1D9
    TBC1D8B    TBC1D9B    TBC1D2B    TBC1D8    TBC1D2    TBC1D6
    GRTP1    RABGAP1L    TBC1D18    FLJ00288    TBC1D1    TBC1D10A

    Find genes that share paralogs with SGSM3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SGSM3 (see all 994)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs60018881,2
    C,H--40764610(+) AGAAAG/CAGTTA 1 -- us2k15Minor allele frequency- C:0.00NS EA CSA 420
    rs1157567651,2
    C,F--40764650(+) GGGCCG/AGGTGC 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1905460281,2
    --40764656(+) GGTGCA/GGTGGT 1 -- us2k10--------
    rs1419473421,2
    --40764778(+) ATACAA/GTCAAC 1 -- us2k10--------
    rs1831924481,2
    --40764800(+) GCAGGC/TGCCTA 1 -- us2k10--------
    rs1506820411,2
    --40764905(+) CCTGGA/GCAACG 1 -- us2k10--------
    rs754376431,2
    F--40764941(+) AAACAG/CAAAAA 1 -- us2k11Minor allele frequency- C:0.03NA 120
    rs1400013851,2
    --40765003(+) GACCAC/GATATT 1 -- us2k10--------
    rs283798701,2
    C--40765110(+) GGATAT/GAGGAT 1 -- us2k11Minor allele frequency- G:0.00NA 2
    rs791354691,2
    F--40765219(+) TTGGCA/GATTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SGSM3 (40766595 - 40806293 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SGSM3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678968CNV Deletion23128226
    esv2724264CNV Deletion23290073
    esv22054CNV Loss19812545
    nsv829233CNV Loss20364138
    nsv829232CNV Loss20364138
    nsv834202CNV Loss17160897
    dgv4977n71CNV Gain21882294

    Human Gene Mutation Database (HGMD): SGSM3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SGSM3
    DNA2.0 Custom Variant and Variant Library Synthesis for SGSM3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610440    OMIM disorders: --


    Find genes that share disorders with SGSM3           About GenesLikeMe

    Genetic Association Database (GAD): SGSM3

    Export disorders for SGSM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SGSM3 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with SGSM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway. (PubMed id 17509819)1, 2, 3 Yang H.... Shimizu N. (Genomics 2007)
    2. A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation. (PubMed id 19570815)1, 4 Estrada K....Kayser M. (Hum. Mol. Genet. 2009)
    3. MAP, a protein interacting with a tumor suppressor, merlin, through the run domain. (PubMed id 15541357)1, 2 Lee I.K....Rha H.K. (Biochem. Biophys. Res. Commun. 2004)
    4. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    5. Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)1, 3 Hattori A.... Ohara O. (DNA Res. 2000)
    6. Association between an insertion/deletion polymorphism within 3'UTR of SGSM3 and risk of hepatocellular carcinoma. (PubMed id 23918301)1 Wang C....Gao Y. (Tumour Biol. 2014)
    7. A functional genomic approach reveals the transcriptional role of EDD in the expression and function of angiogenesis regulator ACVRL1. (PubMed id 24189493)1 Chen H.W....Tan B.C. (Biochim. Biophys. Acta 2013)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27352 HGNC: 25228 AceView: RUTBC3 Ensembl:ENSG00000100359 euGenes: HUgn27352
    ECgene: SGSM3 H-InvDB: SGSM3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SGSM3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SGSM3 gene:
    Search GeneIP for patents involving SGSM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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