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Aliases for SGSM2 Gene

Aliases for SGSM2 Gene

  • Small G Protein Signaling Modulator 2 2 3 5
  • RUN And TBC1 Domain-Containing Protein 1 3 4
  • RUN And TBC1 Domain Containing 1 2 3
  • RUTBC1 3 4
  • Small G Protein Signaling Modulator 2 Protein 3
  • KIAA0397 4

External Ids for SGSM2 Gene

Previous HGNC Symbols for SGSM2 Gene

  • RUTBC1

Previous GeneCards Identifiers for SGSM2 Gene

  • GC17P002188
  • GC17P002137
  • GC17P002240

Summaries for SGSM2 Gene

GeneCards Summary for SGSM2 Gene

SGSM2 (Small G Protein Signaling Modulator 2) is a Protein Coding gene. GO annotations related to this gene include GTPase activator activity and Rab GTPase binding. An important paralog of this gene is SGSM1.

Gene Wiki entry for SGSM2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGSM2 Gene

Genomics for SGSM2 Gene

Regulatory Elements for SGSM2 Gene

Enhancers for SGSM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SGSM2 on UCSC Golden Path with GeneCards custom track

Promoters for SGSM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SGSM2 Gene

2,337,498 bp from pter
2,381,074 bp from pter
43,577 bases
Plus strand

Genomic View for SGSM2 Gene

Genes around SGSM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGSM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGSM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGSM2 Gene

Proteins for SGSM2 Gene

  • Protein details for SGSM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small G protein signaling modulator 2
    Protein Accession:
    Secondary Accessions:
    • A5LGW2
    • B4DH69
    • Q49AC2
    • Q6ZUY2
    • Q8IXU4

    Protein attributes for SGSM2 Gene

    1006 amino acids
    Molecular mass:
    113285 Da
    Quaternary structure:
    • Interacts with RAB4A, RAB11A, RAP1A, RAP1B, RAP2A and RAP2B. No interaction with RAB27A.
    • Sequence=BAA23693.3; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SGSM2 Gene


neXtProt entry for SGSM2 Gene

Post-translational modifications for SGSM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SGSM2 Gene

Domains & Families for SGSM2 Gene

Gene Families for SGSM2 Gene

Protein Domains for SGSM2 Gene


Suggested Antigen Peptide Sequences for SGSM2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Rab-GAP TBC domain.
  • Belongs to the RUTBC family.
  • Contains 1 Rab-GAP TBC domain.
  • Contains 1 RUN domain.
  • Belongs to the RUTBC family.
genes like me logo Genes that share domains with SGSM2: view

Function for SGSM2 Gene

Gene Ontology (GO) - Molecular Function for SGSM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IMP 21808068
GO:0017137 Rab GTPase binding IPI 21808068
genes like me logo Genes that share ontologies with SGSM2: view
genes like me logo Genes that share phenotypes with SGSM2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SGSM2 Gene

Localization for SGSM2 Gene

Subcellular locations from

Jensen Localization Image for SGSM2 Gene COMPARTMENTS Subcellular localization image for SGSM2 gene
Compartment Confidence
nucleus 3
plasma membrane 3
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SGSM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0012505 endomembrane system IBA --
genes like me logo Genes that share ontologies with SGSM2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SGSM2 Gene

Pathways & Interactions for SGSM2 Gene

SuperPathways for SGSM2 Gene

No Data Available

Interacting Proteins for SGSM2 Gene

Gene Ontology (GO) - Biological Process for SGSM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0031338 regulation of vesicle fusion IBA --
GO:0034499 late endosome to Golgi transport IMP 21808068
GO:0043547 positive regulation of GTPase activity IMP 21808068
GO:0090630 activation of GTPase activity IBA --
genes like me logo Genes that share ontologies with SGSM2: view

No data available for Pathways by source and SIGNOR curated interactions for SGSM2 Gene

Drugs & Compounds for SGSM2 Gene

No Compound Related Data Available

Transcripts for SGSM2 Gene

Unigene Clusters for SGSM2 Gene

Small G protein signaling modulator 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SGSM2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a ·
SP1: - - -
SP2: - - - -
SP3: -

ExUns: 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b
SP1: -
SP2: -

Relevant External Links for SGSM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SGSM2 Gene

mRNA expression in normal human tissues for SGSM2 Gene

Protein differential expression in normal tissues from HIPED for SGSM2 Gene

This gene is overexpressed in Tlymphocyte (28.3), Monocytes (27.7), and Blymphocyte (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SGSM2 Gene

Protein tissue co-expression partners for SGSM2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SGSM2 Gene:


SOURCE GeneReport for Unigene cluster for SGSM2 Gene:


mRNA Expression by UniProt/SwissProt for SGSM2 Gene:

Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with SGSM2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SGSM2 Gene

Orthologs for SGSM2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SGSM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SGSM2 34
  • 90.11 (n)
  • 92.84 (a)
SGSM2 35
  • 85 (a)
(Canis familiaris)
Mammalia SGSM2 34
  • 89.67 (n)
  • 92.45 (a)
SRR 35
  • 74 (a)
(Mus musculus)
Mammalia Sgsm2 34
  • 88.35 (n)
  • 92.83 (a)
Sgsm2 16
Sgsm2 35
  • 93 (a)
(Pan troglodytes)
Mammalia SGSM2 34
  • 99.43 (n)
  • 99.43 (a)
SGSM2 35
  • 99 (a)
(Rattus norvegicus)
Mammalia Sgsm2 34
  • 87.68 (n)
  • 92.63 (a)
(Monodelphis domestica)
Mammalia SGSM2 35
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia SGSM2 35
  • 82 (a)
(Gallus gallus)
Aves SGSM2 34
  • 73.53 (n)
  • 79.89 (a)
SGSM2 35
  • 80 (a)
(Anolis carolinensis)
Reptilia SGSM2 35
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sgsm2 34
  • 70.83 (n)
  • 77.29 (a)
(Danio rerio)
Actinopterygii LOC799094 34
  • 70.6 (n)
  • 73.13 (a)
SGSM2 35
  • 72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1695 35
  • 42 (a)
CG32506 35
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GYP7 35
  • 17 (a)
Species where no ortholog for SGSM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SGSM2 Gene

Gene Tree for SGSM2 (if available)
Gene Tree for SGSM2 (if available)

Paralogs for SGSM2 Gene

Paralogs for SGSM2 Gene

(4) SIMAP similar genes for SGSM2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SGSM2: view

Variants for SGSM2 Gene

Sequence variations from dbSNP and Humsavar for SGSM2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs17853891 - 2,361,690(+) GCTTC(A/C)TGCGC nc-transcript-variant, reference, missense
rs745400 - 2,363,505(+) GGACA(A/C/G/T)GCTGG nc-transcript-variant, reference, missense
rs17853888 - 2,363,522(+) GTGCC(A/C/T)GCGAG nc-transcript-variant, reference, synonymous-codon, missense
rs17857178 - 2,364,649(+) CATCC(A/G)CTGCC nc-transcript-variant, reference, synonymous-codon, missense
rs2248821 - 2,365,017(+) GCCTC(A/G)GGGAC nc-transcript-variant, reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for SGSM2 Gene

Variant ID Type Subtype PubMed ID
dgv3082n100 CNV loss 25217958
dgv3083n100 CNV gain 25217958
dgv878e212 CNV loss 25503493
esv1171750 CNV deletion 17803354
esv2715501 CNV deletion 23290073
esv27399 CNV gain+loss 19812545
esv3352482 CNV duplication 20981092
esv3445644 CNV duplication 20981092
esv3582478 CNV loss 25503493
esv3582482 CNV loss 25503493
nsv1055225 CNV loss 25217958
nsv1060897 CNV loss 25217958
nsv1063109 CNV gain 25217958
nsv1066475 CNV loss 25217958
nsv1067416 CNV loss 25217958
nsv1126447 CNV deletion 24896259
nsv1160443 CNV deletion 26073780
nsv1160444 CNV deletion 26073780
nsv1160445 CNV duplication 26073780
nsv469765 CNV loss 16826518
nsv470569 CNV loss 18288195
nsv475785 CNV novel sequence insertion 20440878
nsv512469 CNV loss 21212237
nsv517489 CNV loss 19592680
nsv574224 CNV gain 21841781
nsv820502 CNV deletion 20802225
nsv827858 CNV gain 20364138
nsv833336 CNV loss 17160897
nsv833338 CNV loss 17160897
nsv952104 CNV deletion 24416366

Variation tolerance for SGSM2 Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.29; 70.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SGSM2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SGSM2 Gene

Disorders for SGSM2 Gene

Relevant External Links for SGSM2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SGSM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SGSM2 Gene

Publications for SGSM2 Gene

  1. Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway. (PMID: 17509819) Yang H. … Shimizu N. (Genomics 2007) 2 3 4 65
  2. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 2 3 4 65
  3. RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. (PMID: 21808068) Nottingham R.M. … Pfeffer S.R. (J. Biol. Chem. 2011) 2 3 65
  4. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. (PMID: 21873549) Strawbridge R.J. … Florez J.C. (Diabetes 2011) 3 46 65
  5. Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. (PMID: 19584346) Vasan R.S. … Blankenberg S. (JAMA 2009) 3 46 65

Products for SGSM2 Gene

Sources for SGSM2 Gene

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