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SGSM2 Gene

protein-coding   GIFtS: 50
GCID: GC17P002240

Small G Protein Signaling Modulator 2

(Previous name: RUN and TBC1 domain containing 1)
(Previous symbol: RUTBC1)
  Search for SGSM2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Small G Protein Signaling Modulator 21 2
RUTBC11 2 3
RUN And TBC1 Domain Containing 11 2
RUN And TBC1 Domain-Containing Protein 12 3
KIAA03973 5
Small G Protein Signaling Modulator 2 Protein2

External Ids:    HGNC: 290261   Entrez Gene: 99052   Ensembl: ENSG000001412587   OMIM: 6114185   UniProtKB: O431473   

Export aliases for SGSM2 gene to outside databases

Previous GC identifers: GC17P002188 GC17P002137


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SGSM2 Gene:
SGSM2 (small G protein signaling modulator 2) is a protein-coding gene. GO annotations related to this gene include Rab GTPase activator activity. An important paralog of this gene is SGSM1.

Gene Wiki entry for SGSM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SGSM2 gene promoter:
         CREB   AREB6   deltaCREB   Pax-4a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSGSM2 promoter sequence
   Search Chromatin IP Primers for SGSM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SGSM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

SGSM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SGSM2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P002240:  view genomic region     (about GC identifiers)

Start:
2,240,792 bp from pter      End:
2,284,352 bp from pter
Size:
43,561 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SGSM2_HUMAN, O43147 (See protein sequence)
Recommended Name: Small G protein signaling modulator 2  
Size: 1006 amino acids; 113285 Da
Subunit: Interacts with RAB4A, RAB11A, RAP1A, RAP1B, RAP2A and RAP2B. No interaction with RAB27A
Sequence caution: Sequence=BAA23693.3; Type=Erroneous initiation;
Secondary accessions: A5LGW2 B4DH69 Q49AC2 Q6ZUY2 Q8IXU4
Alternative splicing: 4 isoforms:  O43147-1   O43147-2   O43147-3   O43147-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SGSM2: NX_O43147

Explore proteomics data for SGSM2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SGSM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001091979.1  NP_055668.2  

    ENSEMBL proteins: 
     ENSP00000459218   ENSP00000476800   ENSP00000268989   ENSP00000415107   ENSP00000459126  
     ENSP00000476637   ENSP00000460205   ENSP00000464593   ENSP00000461820  

    SGSM2 Human Recombinant Protein Products:

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    Novus Biologicals SGSM2 Lysate
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    Cloud-Clone Corp. Proteins for SGSM2

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    LSBio Antibodies in human, mouse, rat for SGSM2

    SGSM2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for SGSM2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SGSM: Small G protein signaling modulators

    2 InterPro protein domains:
     IPR000195 Rab-GTPase-TBC_dom
     IPR004012 Run

    Graphical View of Domain Structure for InterPro Entry O43147

    ProtoNet protein and cluster: O43147

    1 Blocks protein domain: IPB000195 RabGAP/TBC domain

    UniProtKB/Swiss-Prot: SGSM2_HUMAN, O43147
    Similarity: Belongs to the RUTBC family
    Similarity: Contains 1 Rab-GAP TBC domain
    Similarity: Contains 1 RUN domain


    SGSM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005097Rab GTPase activator activity IEA--
         
    SGSM2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SGSM2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SGSM2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SGSM2

    miRNA
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    Block miRNA regulation of human, mouse, rat SGSM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SGSM2 (see all 33):
    hsa-miR-1258 hsa-miR-650 hsa-miR-449a hsa-miR-124 hsa-miR-298 hsa-miR-506 hsa-miR-497* hsa-miR-3612
    SwitchGear 3'UTR luciferase reporter plasmidSGSM2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SGSM2
    Predesigned siRNA for gene silencing in human, mouse, rat SGSM2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SGSM2

    Clone
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    OriGene clones in human, mouse for SGSM2 (see all 12)
    OriGene ORF clones in mouse, rat for SGSM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SGSM2 (NM_014853)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SGSM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGSM2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SGSM2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGSM2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol2
    nucleus2
    endosome1
    lysosome1
    vacuole1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SGSM2
    Interactions:

        Search GeneGlobe Interaction Network for SGSM2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for SGSM2 (O431472, 3 ENSP000002689894) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FNBP1LQ5T0N52, 3, ENSP000002712344MINT-64873 I2D: score=5 STRING: ENSP00000271234
    AFPP027712, 3MINT-64867 I2D: score=5 
    CA12O435702, 3MINT-64864 I2D: score=5 
    CELSR3Q9NYQ72, 3MINT-64875 I2D: score=5 
    CHD3Q128732, 3MINT-64876 I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032313regulation of Rab GTPase activity ----

    SGSM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SGSM2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SGSM2 gene (2 alternative transcripts): 
    NM_001098509.1  NM_014853.2  

    Unigene Cluster for SGSM2:

    Small G protein signaling modulator 2
    Hs.513861  [show with all ESTs]
    Unigene Representative Sequence: NM_014853
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000572875 ENST00000573062 ENST00000268989(uc002fum.4) ENST00000426855(uc002fun.4 uc010vqw.2)
    ENST00000574563 ENST00000574650 ENST00000570431 ENST00000574857 ENST00000575367
    ENST00000573717(uc002fuo.2) ENST00000574250 ENST00000572841(uc002fuq.3)
    ENST00000573851 ENST00000572925
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SGSM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SGSM2 (see all 33):
    hsa-miR-1258 hsa-miR-650 hsa-miR-449a hsa-miR-124 hsa-miR-298 hsa-miR-506 hsa-miR-497* hsa-miR-3612
    SwitchGear 3'UTR luciferase reporter plasmidSGSM2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SGSM2
    Predesigned siRNA for gene silencing in human, mouse, rat SGSM2
    Clone
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    OriGene clones in human, mouse for SGSM2 (see all 12)
    OriGene ORF clones in mouse, rat for SGSM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SGSM2 (NM_014853)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SGSM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGSM2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SGSM2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SGSM2
      QuantiTect SYBR Green Assays in human, mouse, rat SGSM2
      QuantiFast Probe-based Assays in human, mouse, rat SGSM2

    Additional mRNA sequence: 

    AB007857.3 AB275762.1 AB449878.1 AK096806.1 AK125203.1 AK294955.1 AK304263.1 BC029251.1 
    BC039204.1 BC061895.1 BC131754.1 

    21 DOTS entries:

    DT.100844122  DT.454587  DT.95161612  DT.100698978  DT.100797421  DT.446103  DT.97847577  DT.100772031 
    DT.91674138  DT.95161605  DT.100695037  DT.101980838  DT.92437748  DT.92437750  DT.92437753  DT.100650560 
    DT.100797420  DT.121010876  DT.121010889  DT.92041202  DT.95348486 

    Selected AceView cDNA sequences (see all 333):

    BI916071 AA730212 BU948002 BG775527 CD108158 BE468221 BM998199 AA293314 
    CR596157 BQ879240 CR590347 BM783768 BM044160 AJ709292 BM797657 CD723340 
    BQ710658 BQ938671 AA788758 AI908431 AI422095 AA348988 BF822974 BM478862 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SGSM2 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a ·
    SP1:                                                                                                        -     -                                         -   
    SP2:                                                                    -                                   -     -                                         -   
    SP3:                                                                                                                                                        -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b
    SP1:                          -                     
    SP2:                          -                     
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for SGSM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SGSM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAAAGGGCC
    SGSM2 Expression
    About this image

    SGSM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SGSM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513861

    UniProtKB/Swiss-Prot: SGSM2_HUMAN, O43147
    Tissue specificity: Widely expressed

        Custom PCR Arrays for SGSM2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGSM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SGSM2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sgsm21 , 5 small G protein signaling modulator 21, 5 88.35(n)1
    92.83(a)1
      11 (45.76 cM)5
    977611  NM_197943.21  NP_922934.21 
     748492615 
    chicken
    (Gallus gallus)
    Aves SGSM21 small G protein signaling modulator 2 73.53(n)
    79.89(a)
      417673  XM_004946793.1  XP_004946850.1 
    lizard
    (Anolis carolinensis)
    Reptilia SGSM26
    small G protein signaling modulator 2
    77(a)
    1 ↔ 1
    GL344126.1(6522-54715)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sgsm21 small G protein signaling modulator 2 70.83(n)
    77.29(a)
      100494226  XM_002935293.2  XP_002935339.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7990941 small G protein signaling modulator 2-like 70.6(n)
    73.13(a)
      799094  XM_003200036.2  XP_003200084.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG16956
    CG325066
    --
    42(a)
    41(a)
    1 ↔ many
    1 ↔ many
    X(20304977-20315623)
    X(20320371-20337247)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GYP76
    GTPase-activating protein for yeast Rab family mem...
    17(a)
    1 → many
    IV(34237-36477) YDL234C


    ENSEMBL Gene Tree for SGSM2 (if available)
    TreeFam Gene Tree for SGSM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SGSM2 gene
    SGSM12  TBC1D172  TBC1D162  TBC1D152  TBC1D252  
    4 SIMAP similar genes for SGSM2 using alignment to 7 protein entries:     SGSM2_HUMAN (see all proteins):
    RUTBC1    SGSM1    DKFZp761D0223    RUTBC2

    SGSM2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SGSM2 (see all 1300)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs20039681,2
    C,F,A,Huntested12266812(+) GCCTGC/G/TGCCCG 4 W C mis115NS NA WA CSA EA EU 5344
    rs1395376001,2
    --2242745(+) TGGGCA/GTGGTG 2 -- int10--------
    rs1443032761,2
    --2242789(+) TGGGAC/TGGGCG 2 -- int10--------
    rs1113356641,2
    C,F--2242821(+) AGACCG/ATCCTG 2 -- int13Minor allele frequency- A:0.50NA WA CSA 6
    rs1848553131,2
    --2242957(+) AGATCG/TTGCCA 2 -- int10--------
    rs1892768811,2
    --2242970(+) GCACTC/TCAGCC 2 -- int10--------
    rs1810041401,2
    --2242996(+) CACTCC/TATCTC 2 -- int10--------
    rs789000901,2
    C,F--2243050(+) TCATGC/TGTTAG 2 -- int11Minor allele frequency- T:0.03WA 118
    rs1409016841,2
    C--2243051(+) CATGCA/GTTAGC 2 -- int10--------
    rs1449387141,2
    C--2243056(+) GTTAGC/TCATGG 2 -- int10--------

    HapMap Linkage Disequilibrium report for SGSM2 (2240792 - 2284352 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SGSM2 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715501CNV Deletion23290073
    esv1171750CNV Deletion17803354
    nsv820502CNV Deletion20802225
    nsv907532CNV Loss21882294
    dgv3036n71CNV Loss21882294
    nsv833336CNV Loss17160897
    nsv470569CNV Loss18288195
    nsv512469CNV Loss21212237
    nsv907537CNV Loss21882294
    nsv833338CNV Loss17160897

    Human Gene Mutation Database (HGMD): SGSM2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SGSM2
    DNA2.0 Custom Variant and Variant Library Synthesis for SGSM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611418    OMIM disorders: --


    SGSM2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SGSM2

    Export disorders for SGSM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SGSM2 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with SGSM2)
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    1. Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway. (PubMed id 17509819)1, 2, 3 Yang H.... Shimizu N. (Genomics 2007)
    2. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1997)
    3. RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. (PubMed id 21808068)1, 3 Nottingham R.M....Pfeffer S.R. (J. Biol. Chem. 2011)
    4. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. (PubMed id 21873549)1, 4 Strawbridge R.J....Florez J.C. (Diabetes 2011)
    5. Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. (PubMed id 19584346)1, 4 Vasan R.S....Blankenberg S. (JAMA 2009)
    6. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PubMed id 19077034)1 Ishibashi K.... Fukuda M. (Genes Cells 2009)
    7. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (Nature 2006)
    8. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9905 HGNC: 29026 AceView: RUTBC1 Ensembl:ENSG00000141258 euGenes: HUgn9905
    ECgene: SGSM2 H-InvDB: SGSM2

    (According to HUGE)
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    HUGE: KIAA0397

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SGSM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SGSM2 gene:
    Search GeneIP for patents involving SGSM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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