Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SGSM2 Gene

Aliases for SGSM2 Gene

  • Small G Protein Signaling Modulator 2 2 3
  • RUN And TBC1 Domain-Containing Protein 1 3 4
  • RUN And TBC1 Domain Containing 1 2 3
  • KIAA0397 4 6
  • RUTBC1 3 4
  • Small G Protein Signaling Modulator 2 Protein 3

External Ids for SGSM2 Gene

Previous Symbols for SGSM2 Gene

  • RUTBC1

Summaries for SGSM2 Gene

GeneCards Summary for SGSM2 Gene

SGSM2 (Small G Protein Signaling Modulator 2) is a Protein Coding gene. An important paralog of this gene is TBC1D25.

Gene Wiki entry for SGSM2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGSM2 Gene

Genomics for SGSM2 Gene

Genomic Location for SGSM2 Gene

Start:
2,337,498 bp from pter
End:
2,381,059 bp from pter
Size:
43,562 bases
Orientation:
Plus strand

Genomic View for SGSM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SGSM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGSM2 Gene

Regulatory Elements for SGSM2 Gene

Proteins for SGSM2 Gene

  • Protein details for SGSM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43147-SGSM2_HUMAN
    Recommended name:
    Small G protein signaling modulator 2
    Protein Accession:
    O43147
    Secondary Accessions:
    • A5LGW2
    • B4DH69
    • Q49AC2
    • Q6ZUY2
    • Q8IXU4

    Protein attributes for SGSM2 Gene

    Size:
    1006 amino acids
    Molecular mass:
    113285 Da
    Quaternary structure:
    • Interacts with RAB4A, RAB11A, RAP1A, RAP1B, RAP2A and RAP2B. No interaction with RAB27A.
    SequenceCaution:
    • Sequence=BAA23693.3; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SGSM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SGSM2 Gene

Proteomics data for SGSM2 Gene at MOPED

Post-translational modifications for SGSM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SGSM2 Gene

Domains for SGSM2 Gene

Gene Families for SGSM2 Gene

HGNC:
  • SGSM :Small G protein signaling modulators

Protein Domains for SGSM2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

SGSM2_HUMAN
Domain:
  • Contains 1 Rab-GAP TBC domain.:
    • O43147
  • Contains 1 RUN domain.:
    • O43147
Family:
  • Belongs to the RUTBC family.:
    • O43147
genes like me logo Genes that share domains with SGSM2: view

Function for SGSM2 Gene

Gene Ontology (GO) - Molecular Function for SGSM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IMP 21808068
GO:0017137 Rab GTPase binding IPI 21808068
genes like me logo Genes that share ontologies with SGSM2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SGSM2 Gene

Localization for SGSM2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SGSM2 Gene COMPARTMENTS Subcellular localization image for SGSM2 gene
Compartment Confidence
plasma membrane 3
cytosol 2
nucleus 2
endosome 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for SGSM2 Gene

Pathways for SGSM2 Gene

SuperPathways for SGSM2 Gene

No Data Available

Interacting Proteins for SGSM2 Gene

Gene Ontology (GO) - Biological Process for SGSM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033126 obsolete positive regulation of GTP catabolic process --
GO:0034499 late endosome to Golgi transport IMP 21808068
GO:0043547 positive regulation of GTPase activity IMP 21808068
genes like me logo Genes that share ontologies with SGSM2: view

No data available for Pathways by source for SGSM2 Gene

Transcripts for SGSM2 Gene

Unigene Clusters for SGSM2 Gene

Small G protein signaling modulator 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SGSM2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a ·
SP1: - - -
SP2: - - - -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

ExUns: 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for SGSM2 Gene

GeneLoc Exon Structure for
SGSM2
ECgene alternative splicing isoforms for
SGSM2

Expression for SGSM2 Gene

mRNA expression in normal human tissues for SGSM2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SGSM2 Gene

SOURCE GeneReport for Unigene cluster for SGSM2 Gene Hs.513861

mRNA Expression by UniProt/SwissProt for SGSM2 Gene

O43147-SGSM2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with SGSM2: view

Orthologs for SGSM2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SGSM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SGSM2 36
  • 99.43 (n)
  • 99.43 (a)
SGSM2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SGSM2 36
  • 90.11 (n)
  • 92.84 (a)
SGSM2 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SGSM2 36
  • 89.67 (n)
  • 92.45 (a)
SRR 37
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sgsm2 36
  • 88.35 (n)
  • 92.83 (a)
Sgsm2 16
Sgsm2 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SGSM2 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SGSM2 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sgsm2 36
  • 87.68 (n)
  • 92.63 (a)
chicken
(Gallus gallus)
Aves SGSM2 36
  • 73.53 (n)
  • 79.89 (a)
SGSM2 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SGSM2 37
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sgsm2 36
  • 70.83 (n)
  • 77.29 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC799094 36
  • 70.6 (n)
  • 73.13 (a)
SGSM2 37
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1695 37
  • 42 (a)
OneToMany
CG32506 37
  • 41 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GYP7 37
  • 17 (a)
OneToMany
Species with no ortholog for SGSM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SGSM2 Gene

ENSEMBL:
Gene Tree for SGSM2 (if available)
TreeFam:
Gene Tree for SGSM2 (if available)

Paralogs for SGSM2 Gene

Paralogs for SGSM2 Gene

Selected SIMAP similar genes for SGSM2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SGSM2: view

Variants for SGSM2 Gene

Sequence variations from dbSNP and Humsavar for SGSM2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs6806 -- 2,380,711(+) GGAAC(A/G)TGGAG utr-variant-3-prime
rs10926 -- 2,380,685(+) AACAC(A/T)TGCAG utr-variant-3-prime
rs745400 - 2,363,505(+) GGACA(A/G)GCTGG missense, reference
rs751434 -- 2,352,390(-) CCACC(A/G)CTGCC intron-variant
rs898750 -- 2,351,899(+) TTCCA(A/G)AGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SGSM2 Gene

Variant ID Type Subtype PubMed ID
nsv833336 CNV Loss 17160897
nsv469765 CNV Complex 16826518
nsv907529 CNV Gain 21882294
nsv517489 CNV Loss 19592680
nsv907530 CNV Loss 21882294
dgv3036n71 CNV Loss 21882294
esv27399 CNV Gain+Loss 19812545
nsv820502 CNV Deletion 20802225
nsv512469 CNV Loss 21212237
esv2715501 CNV Deletion 23290073
esv1171750 CNV Deletion 17803354
nsv907532 CNV Loss 21882294
nsv470569 CNV Loss 18288195
nsv833338 CNV Loss 17160897
nsv907537 CNV Loss 21882294
nsv827858 CNV Gain 20364138

Relevant External Links for SGSM2 Gene

HapMap Linkage Disequilibrium report
SGSM2
Human Gene Mutation Database (HGMD)
SGSM2

Disorders for SGSM2 Gene

Relevant External Links for SGSM2

Genetic Association Database (GAD)
SGSM2
genes like me logo Genes that share disorders with SGSM2: view

No data available for UniProtKB/Swiss-Prot for SGSM2 Gene

Publications for SGSM2 Gene

  1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 2 3 4
  2. Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway. (PMID: 17509819) Yang H. … Shimizu N. (Genomics 2007) 2 3 4
  3. Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. (PMID: 19584346) Vasan R.S. … Blankenberg S. (JAMA 2009) 3 49
  4. RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. (PMID: 21808068) Nottingham R.M. … Pfeffer S.R. (J. Biol. Chem. 2011) 2 3
  5. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. (PMID: 21873549) Strawbridge R.J. … Florez J.C. (Diabetes 2011) 3 49

Products for SGSM2 Gene

Sources for SGSM2 Gene

Back to Top

Content