Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SGSM2 Gene

protein-coding   GIFtS: 48
GCID: GC17P002240

small G protein signaling modulator 2

(Previous name: RUN and TBC1 domain containing 1 )
(Previous symbol: RUTBC1)
  Search for SGSM2
in our new
 Human Malady Compendium 
Biological research products
for SGSM2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Small G Protein Signaling Modulator 21 2
RUTBC11 2 3
RUN And TBC1 Domain Containing 11 2
KIAA03971 3
RUN And TBC1 Domain-Containing Protein 12 3
Small G Protein Signaling Modulator 2 Protein2

External Ids:    HGNC: 290261   Entrez Gene: 99052   Ensembl: ENSG000001412587   OMIM: 6114185   UniProtKB: O431473   

Export aliases for SGSM2 gene to outside databases

Previous GC identifers: GC17P002188 GC17P002137


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for SGSM2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SGSM2 gene promoter:
         CREB   AREB6   deltaCREB   Pax-4a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSGSM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SGSM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SGSM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

SGSM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SGSM2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P002240:  view genomic region     (about GC identifiers)

Start:
2,240,792 bp from pter      End:
2,284,352 bp from pter
Size:
43,561 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SGSM2_HUMAN, O43147 (See protein sequence)
Recommended Name: Small G protein signaling modulator 2  
Size: 1006 amino acids; 113285 Da
Subunit: Interacts with RAB4A, RAB11A, RAP1A, RAP1B, RAP2A and RAP2B. No interaction with RAB27A
Sequence caution: Sequence=BAA23693.3; Type=Erroneous initiation;
Secondary accessions: A5LGW2 B4DH69 Q49AC2 Q6ZUY2 Q8IXU4
Alternative splicing: 4 isoforms:  O43147-1   O43147-2   O43147-3   O43147-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SGSM2: NX_O43147

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43147

  • SGSM2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001091979.1  NP_055668.2  

    ENSEMBL proteins: 
     ENSP00000459218   ENSP00000268989   ENSP00000415107   ENSP00000459126   ENSP00000460205  
     ENSP00000464593   ENSP00000461820  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: SGSM2
    OriGene Custom Protein Services for SGSM2 
    GenScript Custom Purified and Recombinant Proteins Services for SGSM2
    Novus Biologicals SGSM2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SGSM2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--


    SGSM2 for ontologies           About GeneDecksing



    SGSM2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SGSM2 
    GenScript Custom Superior Antibodies Services for SGSM2
    Novus Biologicals SGSM2 Antibodies
    Search for Antibodies for SGSM2 at Abcam  
    Uscn Antibodies for SGSM2
    Search ThermoFisher Antibodies for SGSM2

    Assay Products for SGSM2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SGSM2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SGSM2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SGSM2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000195 Rab-GTPase-TBC_dom
     IPR004012 Run

    Graphical View of Domain Structure for InterPro Entry O43147

    ProtoNet protein and cluster: O43147

    1 Blocks protein family: IPB000195 RabGAP/TBC domain

    UniProtKB/Swiss-Prot: SGSM2_HUMAN, O43147
    Similarity: Belongs to the RUTBC family
    Similarity: Contains 1 Rab-GAP TBC domain
    Similarity: Contains 1 RUN domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 2): SGSM2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SGSM2
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate SGSM2 (see all 33):
    hsa-miR-1258 hsa-miR-650 hsa-miR-449a hsa-miR-124 hsa-miR-298 hsa-miR-506 hsa-miR-497* hsa-miR-3612
    SwitchGear 3'UTR luciferase reporter plasmidSGSM2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SGSM2 (see all 4)
    OriGene shRNA RFP: SGSM2
    OriGene siRNA: SGSM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SGSM2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SGSM2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SGSM2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SGSM2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SGSM2 (NM_014853)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SGSM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGSM2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SGSM2
    Search LifeMap BioReagents cell lines for SGSM2

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGSM2

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005097Rab GTPase activator activity IEA--


    SGSM2 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SGSM2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/15 Interacting proteins for SGSM2 (O431472, 3 ENSP000002689894) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FNBP1LQ5T0N52, 3, ENSP000002712344MINT-64873 I2D: score=5 STRING: ENSP00000271234
    AFPP027712, 3MINT-64867 I2D: score=5 
    CA12O435702, 3MINT-64864 I2D: score=5 
    CELSR3Q9NYQ72, 3MINT-64875 I2D: score=5 
    CHD3Q128732, 3MINT-64876 I2D: score=5 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SGSM2
    Search CenterWatch for drugs/clinical trials and news about SGSM2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SGSM2 gene (2 alternative transcripts): 
    NM_001098509.1  NM_014853.2  

    Unigene Cluster for SGSM2:

    Small G protein signaling modulator 2
    Hs.513861  [show with all ESTs]
    Unigene Representative Sequence: NM_014853
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000572875 ENST00000573062 ENST00000268989(uc002fum.4) ENST00000426855(uc002fun.4 uc010vqw.2)
    ENST00000574563 ENST00000574650 ENST00000570431 ENST00000574857 ENST00000575367
    ENST00000573717(uc002fuo.2) ENST00000574250 ENST00000572841(uc002fuq.3)
    ENST00000573851 ENST00000572925

    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 2): SGSM2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SGSM2
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate SGSM2 (see all 33):
    hsa-miR-1258 hsa-miR-650 hsa-miR-449a hsa-miR-124 hsa-miR-298 hsa-miR-506 hsa-miR-497* hsa-miR-3612
    SwitchGear 3'UTR luciferase reporter plasmidSGSM2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SGSM2 (see all 4)
    OriGene shRNA RFP: SGSM2
    OriGene siRNA: SGSM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SGSM2
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SGSM2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SGSM2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SGSM2 (NM_014853)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SGSM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGSM2 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SGSM2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SGSM2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SGSM2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SGSM2

    Additional cDNA sequence: 

    AB007857.3 AB275762.1 AB449878.1 AK096806.1 AK125203.1 AK294955.1 AK304263.1 BC029251.1 
    BC039204.1 BC061895.1 BC131754.1 

    21 DOTS entries:

    DT.100844122  DT.454587  DT.95161612  DT.100698978  DT.100797421  DT.446103  DT.97847577  DT.100772031 
    DT.91674138  DT.95161605  DT.100695037  DT.101980838  DT.92437748  DT.92437750  DT.92437753  DT.100650560 
    DT.100797420  DT.121010876  DT.121010889  DT.92041202  DT.95348486 

    24/333 AceView cDNA sequences (see all 333):

    BM054839 BG656547 F01396 AI095001 Z39177 BM783272 BM505375 BU947731 
    BQ890164 BU538443 BM747924 BC061895 BQ895965 CR593254 AB007857 BQ054493 
    BM977344 BM786739 BF197693 BI027935 AK124883 BQ068679 BU557812 BM783768 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SGSM2 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a ·
    SP1:                                                                                                        -     -                                         -   
    SP2:                                                                    -                                   -     -                                         -   
    SP3:                                                                                                                                                        -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b
    SP1:                          -                     
    SP2:                          -                     
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for SGSM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SGSM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACAAAGGGCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See SGSM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SGSM2

    SOURCE GeneReport for Unigene cluster: Hs.513861

    UniProtKB/Swiss-Prot: SGSM2_HUMAN, O43147
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for SGSM2
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SGSM2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SGSM2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SGSM2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SGSM2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGSM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SGSM2 gene from 7/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SGSM21 small G protein signaling modulator 2 74(n)
    80.69(a)
      417673  XM_415919.3  XP_415919.3 
    lizard
    (Anolis carolinensis)
    Reptilia SGSM26
    --
    70(a)
    1 ↔ 1
    GL344126.1(6949-54715)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7990941 small G protein signaling modulator 2-like 70.35(n)
    72.94(a)
      799094  XM_003200036.1  XP_003200084.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG16956
    CG325066
    --
    40(a)
    40(a)
    many ↔ many
    many ↔ many
    X(20304977-20315623)
    X(20320371-20337247)
    worm
    (Caenorhabditis elegans)
    Secernentea tbc-86
    Protein TBC-8
    34(a)
    1 → many
    III(10365002-10373138)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G204406
    AT5G547806
    (see all 10)
    RabGAP/TBC domain-containing protein
    (see all 10)
    19(a)
    19(a)
    (see all 10)
    many ↔ many
    many ↔ many
    (see all 10)
    2(8810739-8813644)
    5(22248447-22251863)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 7)
    TBC domain containing protein, expressed
    (see all 7)
    20(a)
    19(a)
    (see all 7)
    many ↔ many
    many ↔ many
    (see all 7)
    7(20409558-20417596)
    11(21801319-21805355)


    ENSEMBL Gene Tree for SGSM2 (if available)
    TreeFam Gene Tree for SGSM2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SGSM2 gene
    SGSM12  TBC1D172  TBC1D212  TBC1D162  TBC1D152  TBC1D252  
    4 SIMAP similar genes for SGSM2 using alignment to 5 protein entries:     SGSM2_HUMAN (see all proteins):
    RUTBC1    SGSM1    DKFZp761D0223    RUTBC2

    SGSM2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1053 NCBI SNPs in SGSM2 are shown (see all 1053    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs20039681,2
    C,F,A,H,other2266812(+) GCCTGC/G/TGCCCG 6 C W syn1 mis115NS NA WA CSA EA EU 5344
    rs1808193701,2
    --2239078(+) CTCCAA/GCATTG 3 -- int1 us2k10--------
    rs1468973471,2
    --2239201(+) ACCTGA/CACGCT 3 -- int1 us2k10--------
    rs1404272991,2
    --2239541(+) AGACGA/GGAGAC 3 -- int1 us2k10--------
    rs1168870071,2
    C,--2239612(+) TCTACG/ATTATC 3 -- int1 us2k11Minor allele frequency- A:0.01NA 120
    rs1122287801,2
    --2239865(+) AGCGCC/TGTGTT 3 -- ut51 us2k11Minor allele frequency- T:0.50CSA 2
    rs1381880901,2
    --2239925(+) GGTTGA/GGGGCT 3 -- ut51 us2k10--------
    rs1865062771,2
    --2240376(+) TCCCAC/GTAATC 3 -- us2k1 ut510--------
    rs1386610361,2
    --2240399(+) TGACAA/TCTGCA 3 -- ut51 us2k10--------
    rs1386519161,2
    --2240400(+) GACAAC/TTGCAC 3 -- us2k1 ut510--------

    HapMap Linkage Disequilibrium report for SGSM2 (2240792 - 2284352 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SGSM2
         1 CNV: 67107
         1 Indel: 25802

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SGSM2
    DNA2.0 Custom Variant and Variant Library Synthesis for SGSM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SGSM2 for disorders           About MalaCards

    SGSM2 for disorders           About GeneDecksing

    OMIM gene information: 611418    OMIM disorders: --


    Export disorders for SGSM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SGSM2 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with SGSM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway. (PubMed id 17509819)1, 2, 3 Yang H....Shimizu N. (2007)
    2. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2, 3 Ishikawa K....Ohara O. (1997)
    3. RUTBC1 protein, a Rab9A effector that activates GTP h ydrolysis by Rab32 and Rab33B proteins. (PubMed id 21808068)1 Nottingham R.M....Pfeffer S.R. (2011)
    4. Genome-wide association identifies nine common variant s associated with fasting proinsulin levels and provides new insights into the p athophysiology of type 2 diabetes. (PubMed id 21873549)1 Strawbridge R.J....Florez J.C. (2011)
    5. Genetic variants associated with cardiac structure an d function: a meta-analysis and replication of genome-wide association data. (PubMed id 19584346)1 Vasan R.S....Blankenberg S. (2009)
    6. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PubMed id 19077034)1 Ishibashi K.... Fukuda M. (2009)
    7. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
    8. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9905 HGNC: 29026 AceView: RUTBC1 Ensembl:ENSG00000141258 euGenes: HUgn9905
    ECgene: SGSM2 H-InvDB: SGSM2

    (According to HUGE)
    About This Section
    HUGE: KIAA0397

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SGSM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SGSM2 gene:
    Search GeneIP for patents involving SGSM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SGSM2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SGSM2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SGSM2  
     OriGene Protein Over-expression Lysate for SGSM2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SGSM2   OriGene 3'-UTR Clone for SGSM2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SGSM2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SGSM2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SGSM2   OriGene Custom Protein Services for SGSM2  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SGSM2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SGSM2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SGSM2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SGSM2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SGSM2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SGSM2
     GenScript Custom Purified and Recombinant Proteins Services for SGSM2 GenScript cDNA clones with any tag delivered in your preferred vector for SGSM2
     GenScript Custom Assay Services for SGSM2 GenScript Custom Superior Antibodies Services for SGSM2
     GenScript Custom overexpressing Cell Line Services for SGSM2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SGSM2 promoter
     Search Chromatin IP Primers for SGSM2
     RT2 qPCR Primer Assay in human, mouse, rat SGSM2
     Search GNC Networks for SGSM2
     SABiosciences Custom PCR Arrays for SGSM2
     Search Tocris compounds for SGSM2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SGSM2 antibodies
     SGSM2 lysates
     Search for Antibodies for SGSM2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SGSM2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SGSM2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SGSM2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGSM2
     SwitchGear 3'UTR luciferase reporter plasmids for SGSM2
     SwitchGear Promoter luciferase reporter plasmids for SGSM2
     Search ThermoFisher Antibodies for SGSM2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGSM2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SGSM2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4