Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SGSM1 Gene

protein-coding   GIFtS: 48
GCID: GC22P025202

Small G Protein Signaling Modulator 1

(Previous name: RUN and TBC1 domain containing 2)
(Previous symbol: RUTBC2)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Small G Protein Signaling Modulator 11 2
RUTBC21 2 3
RUN And TBC1 Domain Containing 21 2
RUN And TBC1 Domain-Containing Protein 22 3
Small G Protein Signaling Modulator 1 Protein2
KIAA19413

External Ids:    HGNC: 294101   Entrez Gene: 1290492   Ensembl: ENSG000001670377   OMIM: 6114175   UniProtKB: Q2NKQ13   

Export aliases for SGSM1 gene to outside databases

Previous GC identifers: GC22P023532 GC22P008151


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for SGSM1 Gene:
SGSM1 (small G protein signaling modulator 1) is a protein-coding gene. Diseases associated with SGSM1 include malaria. GO annotations related to this gene include Rab GTPase activator activity. An important paralog of this gene is TBC1D17.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000022.11  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the SGSM1 gene promoter:
         LUN-1   NF-E2 p45   LCR-F1   FAC1   ARP-1   STAT3   FOXO1a   NF-E2   Zic3   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SGSM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SGSM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.23   Ensembl cytogenetic band:  22q11.23   HGNC cytogenetic band: 22q11.23

SGSM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SGSM1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P025202:  view genomic region     (about GC identifiers)

Start:
25,202,136 bp from pter      End:
25,323,545 bp from pter
Size:
121,410 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SGSM1_HUMAN, Q2NKQ1 (See protein sequence)
Recommended Name: Small G protein signaling modulator 1  
Size: 1148 amino acids; 129718 Da
Subunit: Interacts with RAB3A, RAB4A, RAB5A, RAB8A, RAB11A, RAP1A, RAP1B, RAP2A and RAP2B. No interaction with
RAB27A
Sequence caution: Sequence=BAB85527.1; Type=Erroneous initiation;
Secondary accessions: A5LGW1 A8MUT4 B0QYW0 B0QYW1 B5MEG1 Q5TFL3 Q8TF60
Alternative splicing: 3 isoforms:  Q2NKQ1-1   Q2NKQ1-3   Q2NKQ1-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SGSM1: NX_Q2NKQ1

Explore proteomics data for SGSM1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SGSM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001035037.1  NP_001091967.1  NP_001091968.1  NP_597711.1  

    ENSEMBL proteins: 
     ENSP00000383211   ENSP00000383212  

    SGSM1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SGSM1
    GenScript Custom Purified and Recombinant Proteins Services for SGSM1
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SGSM1

    SGSM1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SGSM1
    OriGene Custom Antibody Services for SGSM1
    Novus Biologicals SGSM1 Antibody
    Abcam antibodies for SGSM1
    Cloud-Clone Corp. Antibodies for SGSM1
    ThermoFisher Antibodies for SGSM1
    LSBio Antibodies in human, mouse, rat for SGSM1

    SGSM1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SGSM1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SGSM1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SGSM1
    Cloud-Clone Corp. CLIAs for SGSM1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SGSM: Small G protein signaling modulators

    2 InterPro protein domains:
     IPR000195 Rab-GTPase-TBC_dom
     IPR004012 Run

    Graphical View of Domain Structure for InterPro Entry Q2NKQ1

    ProtoNet protein and cluster: Q2NKQ1

    1 Blocks protein domain: IPB000195 RabGAP/TBC domain

    UniProtKB/Swiss-Prot: SGSM1_HUMAN, Q2NKQ1
    Similarity: Belongs to the RUTBC family
    Similarity: Contains 1 Rab-GAP TBC domain
    Similarity: Contains 1 RUN domain


    SGSM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005097Rab GTPase activator activity IEA--
         
    SGSM1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SGSM1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SGSM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SGSM1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SGSM1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SGSM1:
    hsa-mir-760 (MIRT036711), hsa-mir-221-5p (MIRT038662)

    Block miRNA regulation of human, mouse, rat SGSM1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SGSM1 (see all 18):
    hsa-miR-140-5p hsa-miR-1197 hsa-miR-575 hsa-miR-218 hsa-miR-507 hsa-miR-9 hsa-miR-133a hsa-miR-2113
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SGSM1
    Predesigned siRNA for gene silencing in human, mouse, rat SGSM1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SGSM1

    Clone
    Products:
         
    OriGene clones in human, mouse for SGSM1 (see all 24)
    OriGene ORF clones in mouse, rat for SGSM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): SGSM1 (NM_133454)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SGSM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGSM1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SGSM1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SGSM1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGSM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SGSM1_HUMAN, Q2NKQ1: Golgi apparatus, trans-Golgi network (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus3
    cytosol2
    endosome1
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IEA--

    SGSM1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SGSM1
    Interactions:

        Search GeneGlobe Interaction Network for SGSM1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SGSM1 (ENSP000003832124) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    --ENSP000002731424STRING: ENSP00000273142
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032313regulation of Rab GTPase activity ----

    SGSM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SGSM1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SGSM1 gene (4 alternative transcripts): 
    NM_001039948.2  NM_001098497.1  NM_001098498.1  NM_133454.2  

    Unigene Cluster for SGSM1:

    Small G protein signaling modulator 1
    Hs.474397  [show with all ESTs]
    Unigene Representative Sequence: AB275761
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000400358(uc003abf.2 uc003abg.2 uc010guu.1 uc003abh.2 uc003abj.2 uc003abi.1)
    ENST00000470591 ENST00000400359 ENST00000473458 ENST00000480523
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SGSM1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SGSM1 (see all 18):
    hsa-miR-140-5p hsa-miR-1197 hsa-miR-575 hsa-miR-218 hsa-miR-507 hsa-miR-9 hsa-miR-133a hsa-miR-2113
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SGSM1
    Predesigned siRNA for gene silencing in human, mouse, rat SGSM1
    Clone
    Products:
         
    OriGene clones in human, mouse for SGSM1 (see all 24)
    OriGene ORF clones in mouse, rat for SGSM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): SGSM1 (NM_133454)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SGSM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGSM1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SGSM1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SGSM1
      QuantiTect SYBR Green Assays in human, mouse, rat SGSM1
      QuantiFast Probe-based Assays in human, mouse, rat SGSM1

    Additional mRNA sequence: 

    AB275761.1 AB449879.1 AK123162.1 AK124850.1 BC036915.1 BC111698.1 

    8 DOTS entries:

    DT.101979627  DT.406131  DT.120663514  DT.406130  DT.100744234  DT.95259482  DT.121234906  DT.75182573 

    Selected AceView cDNA sequences (see all 57):

    H55488 BX107450 AI692308 BX116718 BC036915 AK123162 AI378446 BF507540 
    BM725760 CA390592 AW028652 AW592693 BU740613 H55245 H38281 BM693560 
    H55305 AW292307 AI797011 BU680772 AA622692 BM668881 BI768965 BU584769 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SGSM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGACGGTCAG
    SGSM1 Expression
    About this image

    SGSM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SGSM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.474397

    UniProtKB/Swiss-Prot: SGSM1_HUMAN, Q2NKQ1
    Tissue specificity: Mainly expressed in brain, heart and testis

        Custom PCR Arrays for SGSM1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SGSM1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SGSM1
    QuantiTect SYBR Green Assays in human, mouse, rat SGSM1
    QuantiFast Probe-based Assays in human, mouse, rat SGSM1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGSM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SGSM1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sgsm11 , 5 small G protein signaling modulator 11, 5 86.23(n)1
    93.68(a)1
      5 (55.45 cM)5
    528501  NM_172718.31  NP_766306.21 
     1132432205 
    chicken
    (Gallus gallus)
    Aves SGSM11 small G protein signaling modulator 1 76.78(n)
    79.51(a)
      430664  XM_003642204.2  XP_003642252.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    31(a)
    many ↔ many
    2(71381067-71398281)
    zebrafish
    (Danio rerio)
    Actinopterygii sgsm11 small G protein signaling modulator 1 73.41(n)
    81.68(a)
      100270734  XM_003198619.2  XP_003198667.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG325061 CG32506 65.66(n)
    61.72(a)
      318059  NM_134551.6  NP_608395.6 
    worm
    (Caenorhabditis elegans)
    Secernentea tbc-81 tbc-8 48.47(n)
    40.69(a)
      176454  NM_001268143.1  NP_001255072.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GYP76
    GTPase-activating protein for yeast Rab family mem...
    16(a)
    1 → many
    IV(34237-36477) YDL234C


    ENSEMBL Gene Tree for SGSM1 (if available)
    TreeFam Gene Tree for SGSM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SGSM1 gene
    TBC1D172  TBC1D162  SGSM22  TBC1D152  TBC1D252  
    4 SIMAP similar genes for SGSM1 using alignment to 1 protein entry:     SGSM1_HUMAN:
    RUTBC2    DKFZp761D0223    RUTBC1    SGSM2

    SGSM1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SGSM1
    PGOHUM00000263069


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SGSM1 (see all 3351)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs600276921,2
    C--9131164(+) AAAAA-/AGAAAA 4 -- int10--------
    rs347944821,2
    C--9159055(+) CTCTCT/-TTTTT 4 -- int12Minor allele frequency- -:0.25NA 4
    rs1132853311,2
    C--9230980(+) AAAGGAA/-AAAAA 4 -- int11Minor allele frequency- -:0.50CSA 2
    rs1418316961,2
    --25200291(+) CAGTTC/TATTTC 4 -- us2k10--------
    rs1466017041,2
    --25200336(+) GCTTAC/TGGCCA 4 -- us2k10--------
    rs412815591,2
    C--25200426(+) TAGTCC/TTTCTG 4 -- us2k10--------
    rs1445441321,2
    C--25200456(+) GGGGA-/CCCTAA 4 -- us2k10--------
    rs796320141,2
    C,F--25200513(+) TTGGCC/TCTGCA 4 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1436717471,2
    --25200598(+) TCACTA/GTTTGA 4 -- us2k10--------
    rs1471952271,2
    C--25200605(+) TTGACA/TGGACA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for SGSM1 (25202136 - 25323545 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SGSM1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670598CNV Deletion23128226
    esv2724070CNV Deletion23290073
    esv2724071CNV Deletion23290073
    esv25685CNV Loss19812545
    nsv819966CNV Gain19587683
    nsv834161CNV Gain17160897
    nsv7350OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SGSM1
    DNA2.0 Custom Variant and Variant Library Synthesis for SGSM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 611417    OMIM disorders: --

    1 disease for SGSM1:    
    About MalaCards
    malaria


    SGSM1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SGSM1
    Human Genome Epidemiology (HuGE) Navigator: SGSM1 (4 documents)

    Export disorders for SGSM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SGSM1 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with SGSM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway. (PubMed id 17509819)1, 2, 3 Yang H.... Shimizu N. (Genomics 2007)
    2. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2001)
    3. RUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36. (PubMed id 22637480)1, 3 Nottingham R.M....Pfeffer S.R. (J. Biol. Chem. 2012)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    7. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PubMed id 19077034)1 Ishibashi K.... Fukuda M. (Genes Cells 2009)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I.... Wright H. (Nature 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 129049 HGNC: 29410 AceView: RUTBC2 Ensembl:ENSG00000167037 euGenes: HUgn129049
    ECgene: SGSM1 H-InvDB: SGSM1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1941

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SGSM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SGSM1 gene:
    Search GeneIP for patents involving SGSM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SGSM1   OriGene RNAi products in human, mouse, rat for SGSM1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SGSM1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SGSM1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SGSM1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SGSM1   OriGene Custom Protein Services for SGSM1  

     
     
     Block miRNA regulation of human, mouse, rat SGSM1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SGSM1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SGSM1 Predesigned siRNA for gene silencing in human, mouse, rat SGSM1
     QuantiFast Probe-based Assays in human, mouse, rat SGSM1 QuantiTect SYBR Green Assays in human, mouse, rat SGSM1
     Custom PCR Arrays for SGSM1 Search Chromatin IP Primers for SGSM1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SGSM1  Search GeneGlobe Interaction Network for SGSM1
     Regulatory tfbs in SGSM1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SGSM1 GenScript cDNA clones with any tag delivered in your preferred vector for SGSM1
     GenScript Custom Assay Services for SGSM1 GenScript Custom overexpressing Cell Line Services for SGSM1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SGSM1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SGSM1 antibodies
     Antibodies for SGSM1
     See all of Abcam's Antibodies, Kits and Proteins for SGSM1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SGSM1
     Antibodies for SGSM1
     ELISAs for SGSM1
     CLIAs for SGSM1



     Browse ESI BIO Cell Lines and PureStem Progenitors for SGSM1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGSM1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for SGSM1
     Browse SwitchGear Promoter luciferase reporter plasmids for SGSM1
     ThermoFisher Antibodies for SGSM1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGSM1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SGSM1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SGSM1
     LSBio Antibodies in human, mouse, rat for SGSM1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SGSM1 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4