Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SGSM1 Gene

Aliases for SGSM1 Gene

  • Small G Protein Signaling Modulator 1 2 3
  • RUN And TBC1 Domain-Containing Protein 2 3 4
  • RUN And TBC1 Domain Containing 2 2 3
  • RUTBC2 3 4
  • Small G Protein Signaling Modulator 1 Protein 3
  • KIAA1941 4

External Ids for SGSM1 Gene

Previous HGNC Symbols for SGSM1 Gene

  • RUTBC2

Previous GeneCards Identifiers for SGSM1 Gene

  • GC22P023532
  • GC22P025202
  • GC22P008151

Summaries for SGSM1 Gene

GeneCards Summary for SGSM1 Gene

SGSM1 (Small G Protein Signaling Modulator 1) is a Protein Coding gene. An important paralog of this gene is SGSM2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGSM1 Gene

Genomics for SGSM1 Gene

Regulatory Elements for SGSM1 Gene

Genomic Location for SGSM1 Gene

24,806,169 bp from pter
24,927,578 bp from pter
121,410 bases
Plus strand

Genomic View for SGSM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SGSM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGSM1 Gene

Proteins for SGSM1 Gene

  • Protein details for SGSM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small G protein signaling modulator 1
    Protein Accession:
    Secondary Accessions:
    • A5LGW1
    • A8MUT4
    • B0QYW0
    • B0QYW1
    • B5MEG1
    • B9A6J4
    • Q5TFL3
    • Q8TF60

    Protein attributes for SGSM1 Gene

    1148 amino acids
    Molecular mass:
    129718 Da
    Quaternary structure:
    • Interacts with RAB3A, RAB4A, RAB5A, RAB8A, RAB11A, RAP1A, RAP1B, RAP2A and RAP2B. No interaction with RAB27A.
    • Sequence=BAB85527.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SGSM1 Gene


neXtProt entry for SGSM1 Gene

Proteomics data for SGSM1 Gene at MOPED

Post-translational modifications for SGSM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SGSM1 Gene

No data available for DME Specific Peptides for SGSM1 Gene

Domains for SGSM1 Gene

Gene Families for SGSM1 Gene

Protein Domains for SGSM1 Gene


Suggested Antigen Peptide Sequences for SGSM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Rab-GAP TBC domain.
  • Belongs to the RUTBC family.
  • Contains 1 Rab-GAP TBC domain.
  • Contains 1 RUN domain.
  • Belongs to the RUTBC family.
genes like me logo Genes that share domains with SGSM1: view

Function for SGSM1 Gene

Gene Ontology (GO) - Molecular Function for SGSM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SGSM1: view

Animal Model Products

miRNA for SGSM1 Gene

miRTarBase miRNAs that target SGSM1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for SGSM1 Gene

Localization for SGSM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SGSM1 Gene

Golgi apparatus, trans-Golgi network.

Subcellular locations from

Jensen Localization Image for SGSM1 Gene COMPARTMENTS Subcellular localization image for SGSM1 gene
Compartment Confidence
golgi apparatus 3
cytosol 2
endosome 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SGSM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with SGSM1: view

Pathways for SGSM1 Gene

SuperPathways for SGSM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SGSM1 Gene


No data available for Pathways by source for SGSM1 Gene

Transcripts for SGSM1 Gene

Unigene Clusters for SGSM1 Gene

Small G protein signaling modulator 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SGSM1 Gene

No ASD Table

Relevant External Links for SGSM1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SGSM1 Gene

mRNA expression in normal human tissues for SGSM1 Gene

mRNA differential expression in normal tissues according to GTEx for SGSM1 Gene

This gene is overexpressed in Brain - Hypothalamus (4.5).

Protein differential expression in normal tissues for SGSM1 Gene

This gene is overexpressed in Frontal cortex (46.4), Pancreas (7.6), and Fetal Brain (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SGSM1 Gene

SOURCE GeneReport for Unigene cluster for SGSM1 Gene Hs.474397

mRNA Expression by UniProt/SwissProt for SGSM1 Gene

Tissue specificity: Mainly expressed in brain, heart and testis.
genes like me logo Genes that share expressions with SGSM1: view

Expression partners for SGSM1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SGSM1 Gene

Orthologs for SGSM1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SGSM1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SGSM1 35
  • 90.29 (n)
  • 94.07 (a)
SGSM1 36
  • 93 (a)
(Canis familiaris)
Mammalia SGSM1 35
  • 90.8 (n)
  • 94.16 (a)
SGSM1 36
  • 94 (a)
(Mus musculus)
Mammalia Sgsm1 35
  • 86.23 (n)
  • 93.68 (a)
Sgsm1 16
Sgsm1 36
  • 94 (a)
(Pan troglodytes)
Mammalia SGSM1 35
  • 99.48 (n)
  • 99.48 (a)
SGSM1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Sgsm1 35
  • 86.94 (n)
  • 93.96 (a)
(Monodelphis domestica)
Mammalia SGSM1 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia SGSM1 36
  • 73 (a)
(Gallus gallus)
Aves SGSM1 35
  • 76.78 (n)
  • 79.51 (a)
-- 36
  • 79 (a)
-- 36
  • 91 (a)
-- 36
  • 83 (a)
-- 36
  • 84 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 31 (a)
(Danio rerio)
Actinopterygii sgsm1 35
  • 73.41 (n)
  • 81.68 (a)
SGSM1 (1 of 2) 36
  • 76 (a)
SGSM1 (2 of 2) 36
  • 52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003198 35
  • 58.25 (n)
  • 53.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32506 35
  • 65.66 (n)
  • 61.72 (a)
(Caenorhabditis elegans)
Secernentea tbc-8 35
  • 48.47 (n)
  • 40.69 (a)
tbc-8 36
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GYP7 36
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4794 36
  • 42 (a)
Species with no ortholog for SGSM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SGSM1 Gene

Gene Tree for SGSM1 (if available)
Gene Tree for SGSM1 (if available)

Paralogs for SGSM1 Gene

Paralogs for SGSM1 Gene

(4) SIMAP similar genes for SGSM1 Gene using alignment to 1 proteins: Pseudogenes for SGSM1 Gene

genes like me logo Genes that share paralogs with SGSM1: view

Variants for SGSM1 Gene

Sequence variations from dbSNP and Humsavar for SGSM1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs7288359 -- 24,829,613(+) GTGAG(A/G)CAAGG intron-variant
rs7288726 -- 24,888,099(+) cagtc(C/T)tttgt intron-variant
rs7288853 -- 24,808,773(+) GTCCT(C/T)TAAGG intron-variant
rs7289918 -- 24,824,633(+) TTTGA(A/G)CTCCA intron-variant
rs7287595 -- 24,812,431(+) ACCTC(A/G)TGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SGSM1 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
esv2724070 CNV Deletion 23290073
esv25685 CNV Loss 19812545
nsv834161 CNV Gain 17160897
esv2724071 CNV Deletion 23290073
esv2670598 CNV Deletion 23128226
nsv819966 CNV Gain 19587683

Relevant External Links for SGSM1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SGSM1 Gene

Disorders for SGSM1 Gene

Relevant External Links for SGSM1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for SGSM1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SGSM1 Gene

Publications for SGSM1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  2. Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway. (PMID: 17509819) Yang H. … Shimizu N. (Genomics 2007) 2 3 4
  3. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PMID: 19077034) Ishibashi K. … Fukuda M. (Genes Cells 2009) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for SGSM1 Gene

Sources for SGSM1 Gene

Back to Top