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SGPP2 Gene

protein-coding   GIFtS: 51
GCID: GC02P223288

Sphingosine-1-Phosphate Phosphatase 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sphingosine-1-Phosphate Phosphatase 21 2     Sphingosine 1-Phosphate Phosphohydrolase 22
Sphingosine-1-Phosphatase 22 3     Sphingosine-1-Phosphate Phosphotase 22
SPPase22 3     EC 3.1.3.-3
hSPP22 3     Spp23
SPP22 5     EC 3.1.38

External Ids:    HGNC: 199531   Entrez Gene: 1303672   Ensembl: ENSG000001630827   OMIM: 6128275   UniProtKB: Q8IWX53   

Export aliases for SGPP2 gene to outside databases

Previous GC identifers: GC02P222010 GC02P223252 GC02P223491 GC02P223114 GC02P222997 GC02P215143


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SGPP2 Gene:
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes.
SGPP2 catalyzes the degradation of S1P (Ogawa et al., 2003 (PubMed 12411432)).(supplied by OMIM, Jun 2009)

GeneCards Summary for SGPP2 Gene:
SGPP2 (sphingosine-1-phosphate phosphatase 2) is a protein-coding gene. GO annotations related to this gene include sphingosine-1-phosphate phosphatase activity. An important paralog of this gene is SGPP1.

UniProtKB/Swiss-Prot: SGPP2_HUMAN, Q8IWX5
Function: Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase
activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in
attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SGPP2 gene promoter:
         HOXA9   SREBP-1c   MyoD   MIF-1   LCR-F1   SREBP-1b   Gfi-1   SREBP-1a   ZID   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSGPP2 promoter sequence
   Search Chromatin IP Primers for SGPP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SGPP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.1   Ensembl cytogenetic band:  2q36.1   HGNC cytogenetic band: 2q36.3

SGPP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SGPP2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P223288:  view genomic region     (about GC identifiers)

Start:
223,289,236 bp from pter      End:
223,425,667 bp from pter
Size:
136,432 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SGPP2_HUMAN, Q8IWX5 (See protein sequence)
Recommended Name: Sphingosine-1-phosphate phosphatase 2  
Size: 399 amino acids; 44741 Da
Secondary accessions: A3KPB4 Q8N8Q6
Alternative splicing: 2 isoforms:  Q8IWX5-1   Q8IWX5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SGPP2: NX_Q8IWX5

Explore proteomics data for SGPP2 at MOPED

2 DME Specific Peptides for SGPP2 (Q8IWX5)
 MPSTHAM  IWVLVMY 


See SGPP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_689599.2  
ENSEMBL proteins: 
 ENSP00000315137  
Reactome Protein details: Q8IWX5

SGPP2 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR000326 P_Acid_Pase_2/haloperoxidase

Graphical View of Domain Structure for InterPro Entry Q8IWX5

ProtoNet protein and cluster: Q8IWX5

1 Blocks protein domain: IPB000326 PA-phosphatase related phosphoesterase

UniProtKB/Swiss-Prot: SGPP2_HUMAN, Q8IWX5
Similarity: Belongs to the type 2 lipid phosphate phosphatase family


Find genes that share domains with SGPP2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: SGPP2_HUMAN, Q8IWX5
Function: Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase
activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in
attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling
Induction: Strongly induced by TNF, also induced by bacterial lipopolycaccharides (LPS) in neutrophils,
endothelial cells, and other cell types. Not induced by growth-related factors

     Enzyme Numbers (IUBMB): EC 3.1.32 EC 3.1.3.-1

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003824catalytic activity ----
GO:0042392sphingosine-1-phosphate phosphatase activity IDA12411432
     
Find genes that share ontologies with SGPP2           About GenesLikeMe


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SGPP2
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miRNA
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miRTarBase miRNAs that target SGPP2:
hsa-mir-99a-5p (MIRT048643)

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
SGPP2_HUMAN, Q8IWX5: Endoplasmic reticulum membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
endoplasmic reticulum5
plasma membrane3
peroxisome1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005783endoplasmic reticulum IDA12411432
GO:0005789endoplasmic reticulum membrane TAS--
GO:0016020membrane ----
GO:0016021integral component of membrane IEA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for SGPP2 About    
See pathways by source

SuperPathContained pathways About
1Sphingolipid metabolism
Sphingolipid metabolism0.61
Sphingolipid de novo biosynthesis0.46
Sphingolipid metabolism0.61
Sphingolipid Metabolism0.42
2Metabolism
Metabolism0.38
Metabolism of lipids and lipoproteins0.37
3sphingosine and sphingosine-1-phosphate metabolism
sphingosine and sphingosine-1-phosphate metabolism


Find genes that share SuperPaths with SGPP2           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


2 BioSystems Pathways for SGPP2
    Sphingolipid Metabolism
sphingosine and sphingosine-1-phosphate metabolism

1 Reactome Pathway for SGPP2
    Sphingolipid de novo biosynthesis


1 Kegg Pathway  (Kegg details for SGPP2):
    Sphingolipid metabolism

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SGPP2
Interactions:

    Search GeneGlobe Interaction Network for SGPP2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for SGPP2 (ENSP000003151374) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
InteractantInteraction Details
GeneCardExternal ID(s)
ACER1ENSP000003014524STRING: ENSP00000301452
ACER2ENSP000003426094STRING: ENSP00000342609
ASAH1ENSP000003711524STRING: ENSP00000371152
DEGS1ENSP000003164764STRING: ENSP00000316476
DEGS2ENSP000003071264STRING: ENSP00000307126
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Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006665sphingolipid metabolic process TAS--
GO:0006670sphingosine metabolic process IDA12411432
GO:0016311dephosphorylation IDA12411432
GO:0030148sphingolipid biosynthetic process TAS--
GO:0044281small molecule metabolic process TAS--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SGPP2

4 HMDB Compounds for SGPP2    About this table
CompoundSynonyms CAS #PubMed Ids
Sphinganine2-amino-D-erythro-1,3-Octadecanediol (see all 13)764-22-7--
Sphinganine 1-phosphate2-amino-3-hydroxyoctadecyl dihydrogen phosphate (see all 5)19794-97-9--
Sphingosine(-)-D-erythro-Sphingosine (see all 7)123-78-4--
Sphingosine 1-phosphate(2S,3R,4E)-1-(dihydrogen phosphate)2-amino-4-Octadecene-1,3-diol (see all 4)26993-30-6--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for SGPP2 gene: 
NM_152386.2  

Unigene Cluster for SGPP2:

Sphingosine-1-phosphate phosphatase 2
Hs.591604  [show with all ESTs]
Unigene Representative Sequence: AK096323
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000321276(uc010zlo.2 uc010zlp.2)
miRNA
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Predesigned siRNA for gene silencing in human, mouse, rat SGPP2
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: SGPP2 (NM_152386)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SGPP2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGPP2
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  QuantiTect SYBR Green Assays in human, mouse, rat SGPP2
  QuantiFast Probe-based Assays in human, mouse, rat SGPP2

Additional mRNA sequence: 

AF542512.1 AK096323.1 AK314322.1 BC106904.1 BC106905.1 BC114513.1 BC134342.1 

3 DOTS entries:

DT.413354  DT.65287459  DT.120984700 

Selected AceView cDNA sequences (see all 92):

BX092054 BM833365 AF542512 AA359942 AI245390 BX097353 NM_152386 AW293632 
AW137080 BM127455 AA894432 BM831266 F12459 BF594280 AL709262 AA937401 
AA878935 BG740130 AI830607 CB242467 AI435069 BM832108 BM969969 AI688447 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SGPP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTTCAAGGTG
SGPP2 Expression
About this image


SGPP2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 8) fully expand
 
 Kidney (Urinary System)    fully expand to see all 3 entries
         Ureteric Bud Cells Ureteric Bud
         Ureteric Bud
 
 Heart (Cardiovascular System)
         Cardiomyocyte-like progenitor cells
 
 Endothelium (Cardiovascular System)
         Adult Endothelial Cells Blood Brain Barrier
 
 Neural Ectoderm (Nervous System)
         Neural ectoderm cells
 
 Blood (Hematopoietic System)
         T Helper Cells Peripheral Blood
SGPP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SGPP2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.591604

UniProtKB/Swiss-Prot: SGPP2_HUMAN, Q8IWX5
Tissue specificity: Expressed strongly in kidney and heart, followed by brain, colon, small intestine and lung.
Not detected in skeletal muscle, thymus, spleen, liver, placenta, and peripheral blood leukocytes

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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for SGPP2 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Sgpp21 , 5 sphingosine-1-phosphate phosphotase 21, 5 86.87(n)1
90.65(a)1
  1 (40.23 cM)5
4333231  NM_001004173.21  NP_001004173.11 
 783103465 
chicken
(Gallus gallus)
Aves SGPP21 sphingosine-1-phosphate phosphatase 2 65.55(n)
61.7(a)
  424813  XM_422628.4  XP_422628.3 
lizard
(Anolis carolinensis)
Reptilia SGPP26
sphingosine-1-phosphate phosphatase 2
57(a)
1 ↔ 1
3(25566719-25603247)
tropical clawed frog
(Xenopus tropicalis)
Amphibia sgpp21 sphingosine-1-phosphate phosphatase 2 58.18(n)
55.53(a)
  100489794  XM_002936602.2  XP_002936648.1 
zebrafish
(Danio rerio)
Actinopterygii LOC1003306981 sphingosine-1-phosphate phosphatase 2-like 54.99(n)
50.9(a)
  100330698  XM_002664704.2  XP_002664750.1 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YSR3(YKR053C)4 Dihydrosphingosine 1-phosphate phosphatase, membrane more   --   11(535281-534067) 853927  NP_012979.1 


ENSEMBL Gene Tree for SGPP2 (if available)
TreeFam Gene Tree for SGPP2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SGPP2 gene
SGPP12  
1 SIMAP similar gene for SGPP2 using alignment to 4 protein entries:     SGPP2_HUMAN (see all proteins):
SGPP1

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SGPP2 (see all 2733)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs601108141,2
C--222804536(+) CCCCC-/CCG   
   
/CG/G
CCCGG
2 -- ds5001 cds10--------
rs46730261,2
C,F,A,H--222804819(+) TGGTGT/ATTTTT 1 -- ds500113Minor allele frequency- A:0.10NS EA NA WA CSA 430
rs1389668221,2
C--222804821(+) TGATT-/TTTTG 
        
TTTTG
1 -- ds50010--------
rs1903932931,2
--223287436(+) AGCTTA/GTCTCA 1 -- us2k10--------
rs1169632451,2
C,F--223287640(+) TGCTGC/TGTGTG 1 -- us2k11Minor allele frequency- T:0.01EA 120
rs1137423071,2
C,F--223287655(+) GTTTTG/ACTTTG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
rs1161159991,2
C,F--223287682(+) GGTAGA/GAAGAA 1 -- us2k11Minor allele frequency- G:0.02WA 118
rs1471094041,2
--223287727(+) CAAGTA/GCCTTC 1 -- us2k10--------
rs1807073471,2
C--223287822(+) TTTGCC/GTCACA 1 -- us2k10--------
rs1477387031,2
--223287836(+) GTAAAC/TGACAG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for SGPP2 (223289236 - 223425667 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for SGPP2:    About this table    
Variant IDTypeSubtypePubMed ID
esv2721515CNV Deletion23290073
esv2721516CNV Deletion23290073
nsv528185CNV Loss19592680
esv275407CNV Loss21479260

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SGPP2
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 612827    OMIM disorders: --


Find genes that share disorders with SGPP2           About GenesLikeMe


Export disorders for SGPP2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SGPP2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with SGPP2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification and characterization of a novel human sphingosine-1- phosphate phosphohydrolase, hSPP2. (PubMed id 12411432)1, 2, 3, 9 Ogawa C.... Igarashi Y. (J. Biol. Chem. 2003)
  2. Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses. (PubMed id 17113265)1, 2, 9 Mechtcheriakova D.... Billich A. (Cell. Signal. 2007)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Genetic variants associated with disordered eating. (PubMed id 23568457)1 Wade T.D....Martin N.G. (Int J Eat Disord 2013)
  5. Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung function. (PubMed id 24274704)1 Reardon B.J....Cassano P.A. (BMC Med. Genet. 2013)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  8. Measurement of mammalian sphingosine-1-phosphate phosphohydrolase activity in vitro and in vivo. (PubMed id 17954251)9 Maceyka M....Spiegel S. (Meth. Enzymol. 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 130367 HGNC: 19953 AceView: SGPP2 Ensembl:ENSG00000163082 euGenes: HUgn130367
ECgene: SGPP2 Kegg: 130367 H-InvDB: SGPP2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SGPP2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SGPP2 gene:
Search GeneIP for patents involving SGPP2

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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