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Aliases for SGPP2 Gene

Aliases for SGPP2 Gene

  • Sphingosine-1-Phosphate Phosphatase 2 2 3
  • SPP2 3 4 6
  • Sphingosine-1-Phosphatase 2 3 4
  • SPPase2 3 4
  • HSPP2 3 4
  • Sphingosine 1-Phosphate Phosphohydrolase 2 3
  • Sphingosine-1-Phosphate Phosphotase 2 3
  • EC 3.1.3.- 4
  • EC 3.1.3 64

External Ids for SGPP2 Gene

Summaries for SGPP2 Gene

Entrez Gene Summary for SGPP2 Gene

  • Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP2 catalyzes the degradation of S1P (Ogawa et al., 2003 [PubMed 12411432]).[supplied by OMIM, Jun 2009]

GeneCards Summary for SGPP2 Gene

SGPP2 (Sphingosine-1-Phosphate Phosphatase 2) is a Protein Coding gene. Among its related pathways are Sphingolipid metabolism and Sphingolipid metabolism. GO annotations related to this gene include sphingosine-1-phosphate phosphatase activity. An important paralog of this gene is SGPP1.

UniProtKB/Swiss-Prot for SGPP2 Gene

  • Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGPP2 Gene

Genomics for SGPP2 Gene

Genomic Location for SGPP2 Gene

222,424,052 bp from pter
222,562,623 bp from pter
138,572 bases
Plus strand

Genomic View for SGPP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SGPP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGPP2 Gene

Regulatory Elements for SGPP2 Gene

Proteins for SGPP2 Gene

  • Protein details for SGPP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sphingosine-1-phosphate phosphatase 2
    Protein Accession:
    Secondary Accessions:
    • A3KPB4
    • Q8N8Q6

    Protein attributes for SGPP2 Gene

    399 amino acids
    Molecular mass:
    44741 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SGPP2 Gene


neXtProt entry for SGPP2 Gene

Proteomics data for SGPP2 Gene at MOPED

Selected DME Specific Peptides for SGPP2 Gene

Post-translational modifications for SGPP2 Gene

No Post-translational modifications

Other Protein References for SGPP2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for SGPP2 Gene

Protein Domains for SGPP2 Gene


  • Belongs to the type 2 lipid phosphate phosphatase family.:
    • Q8IWX5
genes like me logo Genes that share domains with SGPP2: view

No data available for Gene Families for SGPP2 Gene

Function for SGPP2 Gene

Molecular function for SGPP2 Gene

UniProtKB/Swiss-Prot Function: Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling.
UniProtKB/Swiss-Prot Induction: Strongly induced by TNF, also induced by bacterial lipopolycaccharides (LPS) in neutrophils, endothelial cells, and other cell types. Not induced by growth-related factors.

Enzyme Numbers (IUBMB) for SGPP2 Gene

Gene Ontology (GO) - Molecular Function for SGPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0042392 sphingosine-1-phosphate phosphatase activity IDA 12411432
genes like me logo Genes that share ontologies with SGPP2: view

miRNA for SGPP2 Gene

miRTarBase miRNAs that target SGPP2

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SGPP2 Gene

Localization for SGPP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SGPP2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SGPP2 Gene COMPARTMENTS Subcellular localization image for SGPP2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for SGPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 12411432
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SGPP2: view

Pathways for SGPP2 Gene

genes like me logo Genes that share pathways with SGPP2: view

Pathways by source for SGPP2 Gene

Interacting Proteins for SGPP2 Gene

Gene Ontology (GO) - Biological Process for SGPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006665 sphingolipid metabolic process TAS --
GO:0006670 sphingosine metabolic process IDA 12411432
GO:0016311 dephosphorylation IDA 12411432
GO:0030148 sphingolipid biosynthetic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with SGPP2: view

Compounds for SGPP2 Gene

(4) HMDB Compounds for SGPP2 Gene

Compound Synonyms Cas Number PubMed IDs
  • 2-amino-D-erythro-1,3-Octadecanediol
Sphinganine 1-phosphate
  • 2-amino-3-hydroxyoctadecyl dihydrogen phosphate
  • (-)-D-erythro-Sphingosine
Sphingosine 1-phosphate
  • (2S,3R,4E)-1-(dihydrogen phosphate)2-amino-4-Octadecene-1,3-diol
genes like me logo Genes that share compounds with SGPP2: view

Transcripts for SGPP2 Gene

mRNA/cDNA for SGPP2 Gene

Unigene Clusters for SGPP2 Gene

Sphingosine-1-phosphate phosphatase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SGPP2 Gene

No ASD Table

Relevant External Links for SGPP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SGPP2 Gene

mRNA expression in normal human tissues for SGPP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SGPP2 Gene

SOURCE GeneReport for Unigene cluster for SGPP2 Gene Hs.591604

mRNA Expression by UniProt/SwissProt for SGPP2 Gene

Tissue specificity: Expressed strongly in kidney and heart, followed by brain, colon, small intestine and lung. Not detected in skeletal muscle, thymus, spleen, liver, placenta, and peripheral blood leukocytes.
genes like me logo Genes that share expressions with SGPP2: view

Orthologs for SGPP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SGPP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SGPP2 36
  • 99 (n)
  • 99.5 (a)
SGPP2 37
  • 99 (a)
(Bos Taurus)
Mammalia SGPP2 36
  • 87.77 (n)
  • 88.69 (a)
SGPP2 37
  • 91 (a)
(Canis familiaris)
Mammalia SGPP2 37
  • 65 (a)
(Mus musculus)
Mammalia Sgpp2 36
  • 86.87 (n)
  • 90.65 (a)
Sgpp2 16
Sgpp2 37
  • 90 (a)
(Monodelphis domestica)
Mammalia SGPP2 37
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia SGPP2 37
  • 77 (a)
(Rattus norvegicus)
Mammalia Sgpp2 36
  • 85.36 (n)
  • 90.93 (a)
(Gallus gallus)
Aves SGPP2 36
  • 65.55 (n)
  • 61.7 (a)
SGPP2 37
  • 59 (a)
(Anolis carolinensis)
Reptilia SGPP2 37
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sgpp2 36
  • 58.18 (n)
  • 55.53 (a)
(Danio rerio)
Actinopterygii LOC100330698 36
  • 54.99 (n)
  • 50.9 (a)
SGPP2 37
  • 45 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LCB3 37
  • 19 (a)
YSR3 37
  • 17 (a)
YSR3 39
sea squirt
(Ciona savignyi)
Ascidiacea CSA.637 37
  • 34 (a)
Species with no ortholog for SGPP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SGPP2 Gene

Gene Tree for SGPP2 (if available)
Gene Tree for SGPP2 (if available)

Paralogs for SGPP2 Gene

Paralogs for SGPP2 Gene

Selected SIMAP similar genes for SGPP2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SGPP2: view

Variants for SGPP2 Gene

Sequence variations from dbSNP and Humsavar for SGPP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs8656 -- 222,562,553(+) GTACT(A/G)TATGT utr-variant-3-prime
rs735678 -- 222,474,863(+) AATTT(A/C)CTTTG intron-variant
rs893090 -- 222,517,843(-) ccccc(C/T)tcaca intron-variant
rs893091 -- 222,531,930(+) TGATG(C/T)TCAGG intron-variant
rs1009411 -- 222,450,455(-) ACTAA(A/C)AATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SGPP2 Gene

Variant ID Type Subtype PubMed ID
nsv528185 CNV Loss 19592680
esv275407 CNV Loss 21479260
esv2721515 CNV Deletion 23290073
esv2721516 CNV Deletion 23290073

Relevant External Links for SGPP2 Gene

HapMap Linkage Disequilibrium report

Disorders for SGPP2 Gene

No disorders were found for SGPP2 Gene.

No data available for UniProtKB/Swiss-Prot for SGPP2 Gene

Publications for SGPP2 Gene

  1. Identification and characterization of a novel human sphingosine-1- phosphate phosphohydrolase, hSPP2. (PMID: 12411432) Ogawa C. … Igarashi Y. (J. Biol. Chem. 2003) 2 3 4 23
  2. Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses. (PMID: 17113265) Mechtcheriakova D. … Billich A. (Cell. Signal. 2007) 3 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Genetic variants associated with disordered eating. (PMID: 23568457) Wade T.D. … Martin N.G. (Int J Eat Disord 2013) 3
  5. Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung function. (PMID: 24274704) Reardon B.J. … Cassano P.A. (BMC Med. Genet. 2013) 3

Products for SGPP2 Gene

Sources for SGPP2 Gene

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