Aliases for SGPP2 Gene
External Ids for SGPP2 Gene
Previous GeneCards Identifiers for SGPP2 Gene
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP2 catalyzes the degradation of S1P (Ogawa et al., 2003 [PubMed 12411432]).[supplied by OMIM, Jun 2009]
GeneCards Summary for SGPP2 Gene
SGPP2 (Sphingosine-1-Phosphate Phosphatase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Sphingolipid metabolism. GO annotations related to this gene include sphingosine-1-phosphate phosphatase activity. An important paralog of this gene is SGPP1.
UniProtKB/Swiss-Prot for SGPP2 Gene
Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling.