Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SGPP2 Gene

protein-coding   GIFtS: 53
GCID: GC02P223288

sphingosine-1-phosphate phosphatase 2

  Search for SGPP2
in our new
 Human Malady Compendium 
Biological research products
for SGPP2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Sphingosine-1-Phosphate Phosphatase 21 2     Sphingosine 1-Phosphate Phosphohydrolase 22
SPP21 2 5     Sphingosine-1-Phosphate Phosphotase 22
Sphingosine-1-Phosphatase 22 3     EC 3.1.3.-3
SPPase22 3     Spp23
HSPP21     EC 3.1.38
FLJ390041     

External Ids:    HGNC: 199531   Entrez Gene: 1303672   Ensembl: ENSG000001630827   OMIM: 6128275   UniProtKB: Q8IWX53   

Export aliases for SGPP2 gene to outside databases

Previous GC identifers: GC02P222010 GC02P223252 GC02P223491 GC02P223114 GC02P222997 GC02P215143


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SGPP2:
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP2
catalyzes the degradation of S1P (Ogawa et al., 2003 (PubMed 12411432)).(supplied by OMIM, Jun 2009)

UniProtKB/Swiss-Prot: SGPP2_HUMAN, Q8IWX5
Function: Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase
activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in
attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SGPP2 gene promoter:
         HOXA9   SREBP-1c   MyoD   MIF-1   LCR-F1   SREBP-1b   Gfi-1   SREBP-1a   ZID   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSGPP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SGPP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SGPP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.1   Ensembl cytogenetic band:  2q36.1   HGNC cytogenetic band: 2q36.3

SGPP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SGPP2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P223288:  view genomic region     (about GC identifiers)

Start:
223,289,236 bp from pter      End:
223,425,667 bp from pter
Size:
136,432 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SGPP2_HUMAN, Q8IWX5 (See protein sequence)
Recommended Name: Sphingosine-1-phosphate phosphatase 2  
Size: 399 amino acids; 44741 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: A3KPB4 Q8N8Q6
Alternative splicing: 2 isoforms:  Q8IWX5-1   Q8IWX5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SGPP2: NX_Q8IWX5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IWX5

  • 2 DME Specific Peptides for SGPP2 (Q8IWX5)
     MPSTHAM  IWVLVMY 

    SGPP2 Protein expression data from MOPED and PaxDb:    About this image 
    SGPP2 Protein Expression
    REFSEQ proteins: NP_689599.2  
    ENSEMBL proteins: 
     ENSP00000315137  
    Reactome Protein details: Q8IWX5
    Human Recombinant Protein Products for SGPP2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: SGPP2
    OriGene Custom Protein Services for SGPP2 
    GenScript Custom Purified and Recombinant Proteins Services for SGPP2
    Novus Biologicals SGPP2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SGPP2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA12411432
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral to membrane IEA--

    SGPP2 for ontologies           About GeneDecksing



    SGPP2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SGPP2 
    GenScript Custom Superior Antibodies Services for SGPP2
    Novus Biologicals SGPP2 Antibody
    Search for Antibodies for SGPP2 at Abcam  
    Uscn Antibodies for SGPP2
    ThermoFisher Antibodies for SGPP2

    Assay Products for SGPP2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SGPP2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SGPP2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SGPP2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000326 P_Acid_Pase_2/haloperoxidase
     IPR016118 P_Acid_Pase/Cl_peroxidase_N

    Graphical View of Domain Structure for InterPro Entry Q8IWX5

    ProtoNet protein and cluster: Q8IWX5

    1 Blocks protein family: IPB000326 PA-phosphatase related phosphoesterase

    UniProtKB/Swiss-Prot: SGPP2_HUMAN, Q8IWX5
    Similarity: Belongs to the type 2 lipid phosphate phosphatase family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SGPP2_HUMAN, Q8IWX5
    Function: Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase
    activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in
    attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling
    Induction: Strongly induced by TNF, also induced by bacterial lipopolycaccharides (LPS) in neutrophils, endothelial
    cells, and other cell types. Not induced by growth-related factors

         Enzyme Numbers (IUBMB): EC 3.1.32 EC 3.1.3.-1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042392sphingosine-1-phosphate phosphatase activity IDA12411432
         
    SGPP2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SGPP2 

    miRNA
    Products:
        
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SGPP2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SGPP2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SGPP2 (see all 4)
    OriGene shRNA RFP: SGPP2
    OriGene siRNA: SGPP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SGPP2
    Sirion Biotech Custom design and validation of potent shRNA sequences against SGPP2 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SGPP2
    Sirion Biotech Customized adenovirus for overexpression of SGPP2 
    Sirion Biotech Customized adenovirus for potent knockdown of SGPP2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SGPP2 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SGPP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SGPP2 (NM_152386)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SGPP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGPP2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SGPP2
    Search LifeMap BioReagents cell lines for SGPP2
    Sirion Biotech Customized stable knockdown cell line services for SGPP2 
    Sirion Biotech Customized inducible knockdown cell line services for SGPP2
    Sirion Biotech Customized stable overexpressing cell line services for SGPP2
    Sirion Biotech Customized inducible overexpressing cell line services for SGPP2

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGPP2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Sphingolipid metabolism
    Sphingolipid metabolism1.00
    Sphingolipid de novo biosynthesis0.46
    Sphingolipid metabolism0.54
    2Metabolism
    Metabolism1.00
    Metabolism of lipids and lipoproteins0.34
    3sphingosine and sphingosine-1-phosphate metabolism
    sphingosine and sphingosine-1-phosphate metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for SGPP2 
        sphingosine and sphingosine-1-phosphate metabolism

    4        Reactome Pathways for SGPP2
        Sphingolipid metabolism
    Metabolism
    Metabolism of lipids and lipoproteins
    Sphingolipid de novo biosynthesis


    1         Kegg Pathway  (Kegg details for SGPP2):
        Sphingolipid metabolism


    SGPP2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SGPP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/25 Interacting proteins for SGPP2 (ENSP000003151374) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACER1ENSP000003014524STRING: ENSP00000301452
    ACER2ENSP000003426094STRING: ENSP00000342609
    ASAH1ENSP000003711524STRING: ENSP00000371152
    DEGS1ENSP000003164764STRING: ENSP00000316476
    DEGS2ENSP000003071264STRING: ENSP00000307126
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006665sphingolipid metabolic process TAS--
    GO:0006670sphingosine metabolic process IDA12411432
    GO:0030148sphingolipid biosynthetic process TAS--
    GO:0044281small molecule metabolic process TAS--

    SGPP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SGPP2

    4 HMDB Compounds for SGPP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Sphinganine2-amino-D-erythro-1,3-Octadecanediol (see all 13)764-22-7--
    Sphinganine 1-phosphate2-amino-3-hydroxyoctadecyl dihydrogen phosphate (see all 5)19794-97-9--
    Sphingosine(-)-D-erythro-Sphingosine (see all 7)123-78-4--
    Sphingosine 1-phosphate(2S,3R,4E)-1-(dihydrogen phosphate)2-amino-4-Octadecene-1,3-diol (see all 4)26993-30-6--
    Search CenterWatch for drugs/clinical trials and news about SGPP2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SGPP2 gene: 
    NM_152386.2  

    Unigene Cluster for SGPP2:

    Sphingosine-1-phosphate phosphatase 2
    Hs.591604  [show with all ESTs]
    Unigene Representative Sequence: AK096323
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000321276(uc010zlo.2 uc010zlp.2)

    miRNA
    Products:
         
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SGPP2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SGPP2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SGPP2 (see all 4)
    OriGene shRNA RFP: SGPP2
    OriGene siRNA: SGPP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SGPP2
    Sirion Biotech Custom design and validation of potent shRNA sequences against SGPP2 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SGPP2 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SGPP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SGPP2 (NM_152386)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SGPP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGPP2 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SGPP2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SGPP2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SGPP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SGPP2

    Additional cDNA sequence: 

    AF542512.1 AK096323.1 AK314322.1 BC106904.1 BC106905.1 BC114513.1 BC134342.1 

    3 DOTS entries:

    DT.413354  DT.65287459  DT.120984700 

    24/92 AceView cDNA sequences (see all 92):

    AF542512 AI245390 AW293632 BM831266 BM833365 AW137080 AA359942 NM_152386 
    BX092054 F12459 AA894432 BX097353 BM127455 AA912676 AL709262 BF594280 
    BE394317 AI792259 AW044497 AK096323 BU782702 AI027330 BM832108 F10080 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SGPP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTCAAGGTG
    SGPP2 Expression
    About this image

    SGPP2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeFrontonasal ProcessHead Mesenchyme
    KidneyRenal VesicleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SGPP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SGPP2

    SOURCE GeneReport for Unigene cluster: Hs.591604

    UniProtKB/Swiss-Prot: SGPP2_HUMAN, Q8IWX5
    Tissue specificity: Expressed strongly in kidney and heart, followed by brain, colon, small intestine and lung. Not
    detected in skeletal muscle, thymus, spleen, liver, placenta, and peripheral blood leukocytes

        SABiosciences Custom PCR Arrays for SGPP2
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SGPP2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SGPP2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SGPP2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SGPP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGPP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SGPP2 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SGPP21 sphingosine-1-phosphate phosphatase 2 65.55(n)
    61.7(a)
      424813  XM_422628.3  XP_422628.3 
    lizard
    (Anolis carolinensis)
    Reptilia SGPP26
    --
    58(a)
    1 ↔ 1
    3(25566719-25603247)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003306981 sphingosine-1-phosphate phosphatase 2-like 54.76(n)
    50.51(a)
      100330698  XM_002664704.1  XP_002664750.1 
    honey bee
    (Apis mellifera)
    Insecta --
    --
    28(a)
    1 → many
    GroupUn.113(1876-3402)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G584906
    Phosphatidic acid phosphatase (PAP2) family protei...
    19(a)
    1 → many
    3(21632812-21635106)
    rice
    (Oryza sativa)
    Liliopsida --
    phosphatase, putative, expressed
    19(a)
    1 → many
    3(33620244-33623220)


    ENSEMBL Gene Tree for SGPP2 (if available)
    TreeFam Gene Tree for SGPP2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SGPP2 gene
    SGPP12  
    1 SIMAP similar gene for SGPP2 using alignment to 4 protein entries:     SGPP2_HUMAN (see all proteins):
    SGPP1

    SGPP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2329 NCBI SNPs in SGPP2 are shown (see all 2329    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113576301,2
    C--215241056(+) CTAGT-/AAATGA 1 -- int11Minor allele frequency- A:0.00NA 2
    rs1903932931,2
    --223287436(+) AGCTTA/GTCTCA 1 -- us2k10--------
    rs1169632451,2
    --223287640(+) TGCTGC/TGTGTG 1 -- us2k11Minor allele frequency- T:0.01EA 120
    rs1137423071,2
    --223287655(+) GTTTTG/ACTTTG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1161159991,2
    C,F--223287682(+) GGTAGA/GAAGAA 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1471094041,2
    --223287727(+) CAAGTA/GCCTTC 1 -- us2k10--------
    rs1807073471,2
    --223287822(+) TTTGCC/GTCACA 1 -- us2k10--------
    rs1477387031,2
    --223287836(+) GTAAAC/TGACAG 1 -- us2k10--------
    rs1850370801,2
    --223288335(+) CCGGCC/TTGCAG 1 -- us2k10--------
    rs1502353211,2
    --223288356(+) TTGCTA/GTCTTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SGPP2 (223289236 - 223425667 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for SGPP2
         5 CNVs: 90294 90297 90295 90296 78981

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SGPP2
    DNA2.0 Custom Variant and Variant Library Synthesis for SGPP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SGPP2 for disorders           About MalaCards

    SGPP2 for disorders           About GeneDecksing

    OMIM gene information: 612827    OMIM disorders: --


    Export disorders for SGPP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SGPP2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SGPP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel human sphingosine-1- phosphate phosphohydrolase, hSPP2. (PubMed id 12411432)1, 2, 3, 9 Ogawa C.... Igarashi Y. (2003)
    2. Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses. (PubMed id 17113265)1, 2, 9 Mechtcheriakova D....Billich A. (2007)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Measurement of mammalian sphingosine-1-phosphate phosphohydrolase activity in vitro and in vivo. (PubMed id 17954251)9 Maceyka M....Spiegel S. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 130367 HGNC: 19953 AceView: SGPP2 Ensembl:ENSG00000163082 euGenes: HUgn130367
    ECgene: SGPP2 Kegg: 130367 H-InvDB: SGPP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SGPP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SGPP2 gene:
    Search GeneIP for patents involving SGPP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SGPP2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SGPP2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SGPP2  
     OriGene Protein Over-expression Lysate for SGPP2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SGPP2   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SGPP2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SGPP2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SGPP2   OriGene Custom Protein Services for SGPP2  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SGPP2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SGPP2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SGPP2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SGPP2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SGPP2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SGPP2
     GenScript Custom Purified and Recombinant Proteins Services for SGPP2 GenScript cDNA clones with any tag delivered in your preferred vector for SGPP2
     GenScript Custom Assay Services for SGPP2 GenScript Custom Superior Antibodies Services for SGPP2
     GenScript Custom overexpressing Cell Line Services for SGPP2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SGPP2 promoter
     Search Chromatin IP Primers for SGPP2
     RT2 qPCR Primer Assay in human, mouse, rat SGPP2
     Search GNC Networks for SGPP2
     SABiosciences Custom PCR Arrays for SGPP2
     Search Tocris compounds for SGPP2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SGPP2 antibodies
     SGPP2 proteins
     Search for Antibodies for SGPP2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SGPP2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SGPP2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SGPP2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGPP2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for SGPP2
     SwitchGear Promoter luciferase reporter plasmids for SGPP2
     ThermoFisher Antibodies for SGPP2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGPP2
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SGPP2
    Sirion Biotech Customized:
     stable knockdown cell line services for SGPP2
     inducible knockdown cell line services for SGPP2
     design and validation of potent shRNA sequences against SGPP2
     adenovirus for potent knockdown of SGPP2
     adenovirus for overexpression of SGPP2
     stable overexpressing cell line services for SGPP2
     inducible overexpressing cell line services for SGPP2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SGPP2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4