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Aliases for SGPP1 Gene

Aliases for SGPP1 Gene

  • Sphingosine-1-Phosphate Phosphatase 1 2 3 5
  • Sphingosine-1-Phosphatase 1 3 4
  • HSPPase1 3 4
  • SPPase1 3 4
  • HSPP1 3 4
  • SPP1 3 4
  • EC 3.1.3.- 4
  • EC 3.1.3 61

External Ids for SGPP1 Gene

Previous GeneCards Identifiers for SGPP1 Gene

  • GC14M057945
  • GC14M062141
  • GC14M062140
  • GC14M063220
  • GC14M064150
  • GC14M044317

Summaries for SGPP1 Gene

Entrez Gene Summary for SGPP1 Gene

  • Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by OMIM, Jun 2009]

GeneCards Summary for SGPP1 Gene

SGPP1 (Sphingosine-1-Phosphate Phosphatase 1) is a Protein Coding gene. Among its related pathways are Sphingolipid metabolism and Sphingolipid signaling pathway. GO annotations related to this gene include sphingosine-1-phosphate phosphatase activity. An important paralog of this gene is SGPP2.

UniProtKB/Swiss-Prot for SGPP1 Gene

  • Has enzymatic activity against both sphingosine 1-phosphate (S1P) and dihydro-S1P. Regulates intracellular and extracellular S1P levels.

Gene Wiki entry for SGPP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGPP1 Gene

Genomics for SGPP1 Gene

Regulatory Elements for SGPP1 Gene

Enhancers for SGPP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G063675 1.2 Ensembl ENCODE 11.4 +50.6 50605 3.5 PKNOX1 FEZF1 BRCA1 ZNF2 GATA2 KLF7 FOS SP3 ZHX2 TSHZ1 ENSG00000200693 SGPP1 RNU7-116P ENSG00000202182 SYNE2 WDR89 GC14P063658
GH14G063469 1.2 Ensembl ENCODE 9.9 +256.3 256329 4.1 HDGF FOXA2 ARID4B ZNF766 FOS JUNB PPARG TBX21 MAFF ATF4 SGPP1 RNU7-116P ENSG00000252800 GC14P063463
GH14G063541 1.1 ENCODE 10.3 +184.9 184932 2.7 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 FEZF1 ZBTB7B YY1 SLC30A9 LOC102723809 ENSG00000252800 SGPP1 RNU7-116P ZBTB1 PPP2R5E
GH14G063704 0.9 Ensembl ENCODE 12.4 +22.5 22520 1.6 MTA2 DPF2 TBX21 IKZF1 EED NBN RELB IKZF2 SPI1 SGPP1 RNU7-116P WDR89 GC14P063658
GH14G063435 1.1 Ensembl ENCODE 10.1 +291.0 290961 3.6 PKNOX1 NFIB FEZF1 RAD21 YY1 SMARCC2 ZNF207 RCOR1 FOS SMARCC1 ENSG00000214770 PPP2R5E ENSG00000252800 RNU7-116P SGPP1 GC14P063451 GPHB5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SGPP1 on UCSC Golden Path with GeneCards custom track

Promoters for SGPP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000069545 1095 3201 FOXA2 ARID4B SIN3A ZNF48 YY1 GLIS2 GATA2 FOS ZNF263 SP5

Genomic Location for SGPP1 Gene

63,684,214 bp from pter
63,728,095 bp from pter
43,882 bases
Minus strand

Genomic View for SGPP1 Gene

Genes around SGPP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGPP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGPP1 Gene

Proteins for SGPP1 Gene

  • Protein details for SGPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sphingosine-1-phosphate phosphatase 1
    Protein Accession:
    Secondary Accessions:
    • B2RAH0
    • Q9H189

    Protein attributes for SGPP1 Gene

    441 amino acids
    Molecular mass:
    49108 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SGPP1 Gene

Selected DME Specific Peptides for SGPP1 Gene


Post-translational modifications for SGPP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SGPP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SGPP1 Gene

Gene Families for SGPP1 Gene

Protein Domains for SGPP1 Gene

Suggested Antigen Peptide Sequences for SGPP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the type 2 lipid phosphate phosphatase family.
  • Belongs to the type 2 lipid phosphate phosphatase family.
genes like me logo Genes that share domains with SGPP1: view

Function for SGPP1 Gene

Molecular function for SGPP1 Gene

UniProtKB/Swiss-Prot Function:
Has enzymatic activity against both sphingosine 1-phosphate (S1P) and dihydro-S1P. Regulates intracellular and extracellular S1P levels.

Enzyme Numbers (IUBMB) for SGPP1 Gene

Gene Ontology (GO) - Molecular Function for SGPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0042392 sphingosine-1-phosphate phosphatase activity TAS --
GO:0070780 dihydrosphingosine-1-phosphate phosphatase activity TAS --
genes like me logo Genes that share ontologies with SGPP1: view
genes like me logo Genes that share phenotypes with SGPP1: view

Animal Models for SGPP1 Gene

MGI Knock Outs for SGPP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SGPP1

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SGPP1 Gene

Localization for SGPP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SGPP1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SGPP1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for SGPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SGPP1: view

Pathways & Interactions for SGPP1 Gene

genes like me logo Genes that share pathways with SGPP1: view

Gene Ontology (GO) - Biological Process for SGPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006665 sphingolipid metabolic process IEA --
GO:0006668 sphinganine-1-phosphate metabolic process IEA --
GO:0006670 sphingosine metabolic process IEA --
GO:0016311 dephosphorylation IEA --
GO:0030148 sphingolipid biosynthetic process TAS --
genes like me logo Genes that share ontologies with SGPP1: view

No data available for SIGNOR curated interactions for SGPP1 Gene

Drugs & Compounds for SGPP1 Gene

(5) Drugs for SGPP1 Gene - From: DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Sonepcizumab Pharma Antibody Others 0
sphinganine Pharma 0

(2) Additional Compounds for SGPP1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sphinganine 1-phosphate
  • 2-Amino-3-hydroxyoctadecyl dihydrogen phosphate
  • Dihydrosphingosine 1-phosphate
  • Dihydrosphingosine-1-phosphate
  • Sphinganine 1-phosphate
genes like me logo Genes that share compounds with SGPP1: view

Transcripts for SGPP1 Gene

mRNA/cDNA for SGPP1 Gene

Unigene Clusters for SGPP1 Gene

Sphingosine-1-phosphate phosphatase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SGPP1 Gene

No ASD Table

Relevant External Links for SGPP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SGPP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SGPP1 Gene

Protein differential expression in normal tissues from HIPED for SGPP1 Gene

This gene is overexpressed in Breast (36.3) and Lung (17.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SGPP1 Gene

Protein tissue co-expression partners for SGPP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SGPP1 Gene:


SOURCE GeneReport for Unigene cluster for SGPP1 Gene:


mRNA Expression by UniProt/SwissProt for SGPP1 Gene:

Tissue specificity: Ubiquitous, with the strongest level in placenta and kidney.

Evidence on tissue expression from TISSUES for SGPP1 Gene

  • Nervous system(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with SGPP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SGPP1 Gene

Orthologs for SGPP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SGPP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SGPP1 34 35
  • 99.02 (n)
(Canis familiaris)
Mammalia SGPP1 34 35
  • 92.44 (n)
(Bos Taurus)
Mammalia SGPP1 34 35
  • 91.08 (n)
(Mus musculus)
Mammalia Sgpp1 34 16 35
  • 82.79 (n)
(Rattus norvegicus)
Mammalia Sgpp1 34
  • 81.78 (n)
(Ornithorhynchus anatinus)
Mammalia SGPP1 35
  • 74 (a)
(Monodelphis domestica)
Mammalia SGPP1 35
  • 68 (a)
(Gallus gallus)
Aves SGPP1 34
  • 78.98 (n)
(Anolis carolinensis)
Reptilia SGPP1 35
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sgpp1 34
  • 69.78 (n)
Str.6321 34
(Danio rerio)
Actinopterygii sgpp1 34 35
  • 61.33 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009675 34
  • 48.64 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LCB3 35 37
  • 22 (a)
YSR3 35
  • 20 (a)
Species where no ortholog for SGPP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SGPP1 Gene

Gene Tree for SGPP1 (if available)
Gene Tree for SGPP1 (if available)

Paralogs for SGPP1 Gene

Paralogs for SGPP1 Gene

(1) SIMAP similar genes for SGPP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SGPP1: view

Variants for SGPP1 Gene

Sequence variations from dbSNP and Humsavar for SGPP1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000218581 -- 63,717,641(+) CCAAA(A/G)AACCG intron-variant
rs1000345584 -- 63,689,570(+) GGTGG(A/G/T)AGGAT intron-variant
rs1000351708 -- 63,711,576(+) CTTCT(C/T)TGGGG intron-variant
rs1000368969 -- 63,717,596(+) GGATT(A/G)CAGGC intron-variant
rs1000422426 -- 63,724,076(+) GGTCT(C/T)GCTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SGPP1 Gene

Variant ID Type Subtype PubMed ID
dgv137n21 CNV gain 19592680
esv2748779 CNV deletion 23290073
esv3426790 CNV insertion 20981092
esv3892555 CNV loss 25118596
nsv1037824 CNV gain 25217958
nsv1038825 CNV gain 25217958
nsv1044325 CNV gain 25217958
nsv1116513 OTHER inversion 24896259
nsv1138309 CNV deletion 24896259

Variation tolerance for SGPP1 Gene

Residual Variation Intolerance Score: 37.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SGPP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SGPP1 Gene

Disorders for SGPP1 Gene

Relevant External Links for SGPP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SGPP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SGPP1 Gene

Publications for SGPP1 Gene

  1. Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability. (PMID: 12815058) Johnson K.R. … Obeid L.M. (J. Biol. Chem. 2003) 3 4 22 64
  2. Genetic determinants of circulating sphingolipid concentrations in European populations. (PMID: 19798445) Hicks A.A. … Campbell H. (PLoS Genet. 2009) 3 46 64
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis. (PMID: 15180992) Le Stunff H. … Spiegel S. (J. Biol. Chem. 2004) 3 22 64

Products for SGPP1 Gene

Sources for SGPP1 Gene

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