Aliases for SGPP1 Gene
External Ids for SGPP1 Gene
Previous GeneCards Identifiers for SGPP1 Gene
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by OMIM, Jun 2009]
GeneCards Summary for SGPP1 Gene
SGPP1 (Sphingosine-1-Phosphate Phosphatase 1) is a Protein Coding gene. Among its related pathways are Metabolism and sphingosine and sphingosine-1-phosphate metabolism. GO annotations related to this gene include sphingosine-1-phosphate phosphatase activity. An important paralog of this gene is SGPP2.
UniProtKB/Swiss-Prot for SGPP1 Gene
Has enzymatic activity against both sphingosine 1-phosphate (S1P) and dihydro-S1P. Regulates intracellular and extracellular S1P levels.