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Aliases for SGPP1 Gene

Aliases for SGPP1 Gene

  • Sphingosine-1-Phosphate Phosphatase 1 2 3 5
  • Sphingosine-1-Phosphatase 1 3 4
  • HSPPase1 3 4
  • SPPase1 3 4
  • HSPP1 3 4
  • SPP1 3 4
  • EC 3.1.3.- 4
  • EC 3.1.3 63

External Ids for SGPP1 Gene

Previous GeneCards Identifiers for SGPP1 Gene

  • GC14M057945
  • GC14M062141
  • GC14M062140
  • GC14M063220
  • GC14M064150
  • GC14M044317

Summaries for SGPP1 Gene

Entrez Gene Summary for SGPP1 Gene

  • Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by OMIM, Jun 2009]

GeneCards Summary for SGPP1 Gene

SGPP1 (Sphingosine-1-Phosphate Phosphatase 1) is a Protein Coding gene. Among its related pathways are Sphingolipid signaling pathway and Metabolism. GO annotations related to this gene include sphingosine-1-phosphate phosphatase activity. An important paralog of this gene is SGPP2.

UniProtKB/Swiss-Prot for SGPP1 Gene

  • Has enzymatic activity against both sphingosine 1-phosphate (S1P) and dihydro-S1P. Regulates intracellular and extracellular S1P levels.

Gene Wiki entry for SGPP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGPP1 Gene

Genomics for SGPP1 Gene

Regulatory Elements for SGPP1 Gene

Enhancers for SGPP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SGPP1 on UCSC Golden Path with GeneCards custom track

Promoters for SGPP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SGPP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SGPP1 Gene

63,684,214 bp from pter
63,728,095 bp from pter
43,882 bases
Minus strand

Genomic View for SGPP1 Gene

Genes around SGPP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGPP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGPP1 Gene

Proteins for SGPP1 Gene

  • Protein details for SGPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sphingosine-1-phosphate phosphatase 1
    Protein Accession:
    Secondary Accessions:
    • B2RAH0
    • Q9H189

    Protein attributes for SGPP1 Gene

    441 amino acids
    Molecular mass:
    49108 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SGPP1 Gene

Proteomics data for SGPP1 Gene at MOPED

Selected DME Specific Peptides for SGPP1 Gene

Post-translational modifications for SGPP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SGPP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for SGPP1 Gene

Gene Families for SGPP1 Gene

Protein Domains for SGPP1 Gene

Suggested Antigen Peptide Sequences for SGPP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the type 2 lipid phosphate phosphatase family.
  • Belongs to the type 2 lipid phosphate phosphatase family.
genes like me logo Genes that share domains with SGPP1: view

Function for SGPP1 Gene

Molecular function for SGPP1 Gene

UniProtKB/Swiss-Prot Function:
Has enzymatic activity against both sphingosine 1-phosphate (S1P) and dihydro-S1P. Regulates intracellular and extracellular S1P levels.

Enzyme Numbers (IUBMB) for SGPP1 Gene

genes like me logo Genes that share phenotypes with SGPP1: view

Animal Models for SGPP1 Gene

MGI Knock Outs for SGPP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SGPP1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SGPP1 Gene

Localization for SGPP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SGPP1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SGPP1 Gene COMPARTMENTS Subcellular localization image for SGPP1 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for SGPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SGPP1: view

Pathways & Interactions for SGPP1 Gene

genes like me logo Genes that share pathways with SGPP1: view

Gene Ontology (GO) - Biological Process for SGPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006670 sphingosine metabolic process IEA --
GO:0030148 sphingolipid biosynthetic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0097193 intrinsic apoptotic signaling pathway IEA --
genes like me logo Genes that share ontologies with SGPP1: view

No data available for SIGNOR curated interactions for SGPP1 Gene

Drugs & Compounds for SGPP1 Gene

(3) Drugs for SGPP1 Gene - From: DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sonepcizumab Pharma Antibody Others 0
sphinganine Pharma 0

(4) Additional Compounds for SGPP1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
sphinganine 1-phosphate
  • 2-Amino-3-hydroxyoctadecyl dihydrogen phosphate
  • Dihydrosphingosine 1-phosphate
  • Dihydrosphingosine-1-phosphate
  • Sphinganine 1-phosphate
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with SGPP1: view

Transcripts for SGPP1 Gene

mRNA/cDNA for SGPP1 Gene

Unigene Clusters for SGPP1 Gene

Sphingosine-1-phosphate phosphatase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SGPP1 Gene

No ASD Table

Relevant External Links for SGPP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SGPP1 Gene

mRNA expression in normal human tissues for SGPP1 Gene

Protein differential expression in normal tissues from HIPED for SGPP1 Gene

This gene is overexpressed in Breast (36.3) and Lung (17.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SGPP1 Gene

SOURCE GeneReport for Unigene cluster for SGPP1 Gene Hs.24678

mRNA Expression by UniProt/SwissProt for SGPP1 Gene

Tissue specificity: Ubiquitous, with the strongest level in placenta and kidney.
genes like me logo Genes that share expression patterns with SGPP1: view

Protein tissue co-expression partners for SGPP1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SGPP1 Gene

Orthologs for SGPP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SGPP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SGPP1 35
  • 91.08 (n)
  • 85.71 (a)
SGPP1 36
  • 84 (a)
(Canis familiaris)
Mammalia SGPP1 35
  • 92.44 (n)
  • 90.7 (a)
SGPP1 36
  • 89 (a)
(Mus musculus)
Mammalia Sgpp1 35
  • 82.79 (n)
  • 80.47 (a)
Sgpp1 16
Sgpp1 36
  • 80 (a)
(Pan troglodytes)
Mammalia SGPP1 35
  • 99.02 (n)
  • 98.64 (a)
SGPP1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Sgpp1 35
  • 81.78 (n)
  • 81.31 (a)
(Monodelphis domestica)
Mammalia SGPP1 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia SGPP1 36
  • 74 (a)
(Gallus gallus)
Aves SGPP1 35
  • 78.98 (n)
  • 78.34 (a)
(Anolis carolinensis)
Reptilia SGPP1 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sgpp1 35
  • 69.78 (n)
  • 68.43 (a)
Str.6321 35
(Danio rerio)
Actinopterygii sgpp1 35
  • 61.33 (n)
  • 59.76 (a)
sgpp1 36
  • 57 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009675 35
  • 48.64 (n)
  • 39.88 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LCB3 36
  • 22 (a)
YSR3 36
  • 20 (a)
LCB3 38
Species with no ortholog for SGPP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SGPP1 Gene

Gene Tree for SGPP1 (if available)
Gene Tree for SGPP1 (if available)

Paralogs for SGPP1 Gene

Paralogs for SGPP1 Gene

(1) SIMAP similar genes for SGPP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SGPP1: view

Variants for SGPP1 Gene

Sequence variations from dbSNP and Humsavar for SGPP1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs7492785 -- 63,683,824(+) CAAAA(C/T)AAAAT downstream-variant-500B
rs7493729 -- 63,688,344(+) aaaaa(A/T)tttaa intron-variant
rs8003077 -- 63,721,875(+) TGTTG(C/T)ATATG intron-variant
rs8017835 -- 63,694,608(+) ATCAG(A/C)AAAAG intron-variant
rs8004212 -- 63,723,590(+) ggtgt(C/G)cgcct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SGPP1 Gene

Variant ID Type Subtype PubMed ID
dgv137n21 CNV Gain 19592680
esv2748779 CNV Deletion 23290073

Variation tolerance for SGPP1 Gene

Residual Variation Intolerance Score: 37.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.23% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SGPP1 Gene

Disorders for SGPP1 Gene

Relevant External Links for SGPP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SGPP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SGPP1 Gene

Publications for SGPP1 Gene

  1. Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability. (PMID: 12815058) Johnson K.R. … Obeid L.M. (J. Biol. Chem. 2003) 3 4 23 67
  2. Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis. (PMID: 15180992) Le Stunff H. … Spiegel S. (J. Biol. Chem. 2004) 3 23
  3. Identification and characterization of a novel human sphingosine-1- phosphate phosphohydrolase, hSPP2. (PMID: 12411432) Ogawa C. … Igarashi Y. (J. Biol. Chem. 2003) 3 23
  4. Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death. (PMID: 10859351) Mandala S.M. … Spiegel S. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for SGPP1 Gene

Sources for SGPP1 Gene