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SGPP1 Gene

protein-coding   GIFtS: 57
GCID: GC14M064150

Sphingosine-1-Phosphate Phosphatase 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sphingosine-1-Phosphate Phosphatase 11 2     spp12
Sphingosine-1-Phosphatase 12 3     EC 3.1.3.-3
SPPase12 3     Spp13
hSPP12 3     SPPASE15
hSPPase12 3     EC 3.1.38

External Ids:    HGNC: 177201   Entrez Gene: 815372   Ensembl: ENSG000001268217   OMIM: 6128265   UniProtKB: Q9BX953   

Export aliases for SGPP1 gene to outside databases

Previous GC identifers: GC14M057945 GC14M062141 GC14M062140 GC14M063220 GC14M044317


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SGPP1 Gene:
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes.
SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides
(Mandala et al., 2000 (PubMed 10859351); Le Stunff et al., 2007 (PubMed 17895250)).(supplied by OMIM, Jun 2009)

GeneCards Summary for SGPP1 Gene:
SGPP1 (sphingosine-1-phosphate phosphatase 1) is a protein-coding gene. GO annotations related to this gene include sphingosine-1-phosphate phosphatase activity. An important paralog of this gene is SGPP2.

UniProtKB/Swiss-Prot: SGPP1_HUMAN, Q9BX95
Function: Has enzymatic activity against both sphingosine 1-phosphate (S1P) and dihydro-S1P. Regulates
intracellular and extracellular S1P levels

Gene Wiki entry for SGPP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SGPP1 gene promoter:
         GR   NF-1   AML1a   Brachyury   GCNF   LCR-F1   GCNF-1   GR-alpha   ZID   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSGPP1 promoter sequence
   Search Chromatin IP Primers for SGPP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SGPP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.2   Ensembl cytogenetic band:  14q23.2   HGNC cytogenetic band: 14q23.1

SGPP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SGPP1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M064150:  view genomic region     (about GC identifiers)

Start:
64,150,932 bp from pter      End:
64,194,757 bp from pter
Size:
43,826 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SGPP1_HUMAN, Q9BX95 (See protein sequence)
Recommended Name: Sphingosine-1-phosphate phosphatase 1  
Size: 441 amino acids; 49108 Da
Secondary accessions: B2RAH0 Q9H189

Explore the universe of human proteins at neXtProt for SGPP1: NX_Q9BX95

Explore proteomics data for SGPP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for SGPP1 (Q9BX95)
     MPSTHAM  IWVLVMY 


    See SGPP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_110418.1  
    ENSEMBL proteins: 
     ENSP00000247225  
    Reactome Protein details: Q9BX95

    SGPP1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000326 P_Acid_Pase_2/haloperoxidase

    Graphical View of Domain Structure for InterPro Entry Q9BX95

    ProtoNet protein and cluster: Q9BX95

    1 Blocks protein domain: IPB000326 PA-phosphatase related phosphoesterase

    UniProtKB/Swiss-Prot: SGPP1_HUMAN, Q9BX95
    Similarity: Belongs to the type 2 lipid phosphate phosphatase family


    Find genes that share domains with SGPP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SGPP1_HUMAN, Q9BX95
    Function: Has enzymatic activity against both sphingosine 1-phosphate (S1P) and dihydro-S1P. Regulates
    intracellular and extracellular S1P levels

         Enzyme Numbers (IUBMB): EC 3.1.32 EC 3.1.3.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0042392sphingosine-1-phosphate phosphatase activity IEA--
         
    Find genes that share ontologies with SGPP1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for SGPP1:
     Decreased cilium length  Decreased cilium length after   Increased apoptosis  Increased cell spreading 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sgpp1):
     cellular  growth/size/body  homeostasis/metabolism  integument  mortality/aging 

    Find genes that share phenotypes with SGPP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sgpp1tm1(KOMP)Vlcg for SGPP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SGPP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SGPP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SGPP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SGPP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SGPP1:
    hsa-mir-34a-5p (MIRT025318), hsa-mir-128-3p (MIRT021888), hsa-mir-215-5p (MIRT024760), hsa-mir-192-5p (MIRT026208)

    Block miRNA regulation of human, mouse, rat SGPP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SGPP1 (see all 12):
    hsa-miR-34c-5p hsa-miR-448 hsa-miR-449b hsa-miR-27a hsa-miR-133b hsa-miR-449a hsa-miR-34a hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidSGPP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SGPP1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGPP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SGPP1_HUMAN, Q9BX95: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SGPP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SGPP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Sphingolipid metabolism
    Sphingolipid metabolism0.61
    Sphingolipid de novo biosynthesis0.46
    Sphingolipid metabolism0.61
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3S1P3 pathway
    Sphingosine 1-phosphate (S1P) pathway0.40
    4sphingosine and sphingosine-1-phosphate metabolism
    sphingosine and sphingosine-1-phosphate metabolism


    Find genes that share SuperPaths with SGPP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for SGPP1
        sphingosine and sphingosine-1-phosphate metabolism
    Sphingosine 1-phosphate (S1P) pathway

    1 Reactome Pathway for SGPP1
        Sphingolipid de novo biosynthesis


    1 Kegg Pathway  (Kegg details for SGPP1):
        Sphingolipid metabolism

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SGPP1
    Interactions:

        Search GeneGlobe Interaction Network for SGPP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SGPP1 (Q9BX953 ENSP000002472254) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    S1PR5Q9H2283, ENSP000003284724I2D: score=1 STRING: ENSP00000328472
    ACER2ENSP000003426094STRING: ENSP00000342609
    ASAH1ENSP000003711524STRING: ENSP00000371152
    ASAH2ENSP000003788974STRING: ENSP00000378897
    DEGS1ENSP000003164764STRING: ENSP00000316476
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    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006665sphingolipid metabolic process TAS--
    GO:0006668sphinganine-1-phosphate metabolic process IEA--
    GO:0006670sphingosine metabolic process IEA--
    GO:0006915apoptotic process ----
    GO:0030148sphingolipid biosynthetic process TAS--

    Find genes that share ontologies with SGPP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SGPP1

    2 Novoseek inferred chemical compound relationships for SGPP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sphingosine 83.1 1 17954251 (1)
    lipid 17.3 3 17555747 (1), 12411432 (1)



    Find genes that share compounds with SGPP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SGPP1 gene: 
    NM_030791.2  

    Unigene Cluster for SGPP1:

    Sphingosine-1-phosphate phosphatase 1
    Hs.24678  [show with all ESTs]
    Unigene Representative Sequence: BC070060
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000247225(uc001xgj.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat SGPP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SGPP1 (see all 12):
    hsa-miR-34c-5p hsa-miR-448 hsa-miR-449b hsa-miR-27a hsa-miR-133b hsa-miR-449a hsa-miR-34a hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidSGPP1 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SGPP1
      QuantiTect SYBR Green Assays in human, mouse, rat SGPP1
      QuantiFast Probe-based Assays in human, mouse, rat SGPP1

    Additional mRNA sequence: 

    AF349315.1 AJ293294.1 AK314188.1 BC063839.1 BC070060.1 

    4 DOTS entries:

    DT.444313  DT.92426393  DT.95165317  DT.120745397 

    Selected AceView cDNA sequences (see all 87):

    AJ293294 BC063839 AI362319 AW469435 AW511874 BX109957 AI581365 R80721 
    BQ026649 AA490518 AI359440 BC070060 AI581085 NM_030791 AA331563 AW955216 
    AA371461 AA261954 BM976596 AI762918 AA994978 AI422866 BG573632 AA376229 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SGPP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGGAAAATA
    SGPP1 Expression
    About this image

    SGPP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SGPP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.24678

    UniProtKB/Swiss-Prot: SGPP1_HUMAN, Q9BX95
    Tissue specificity: Ubiquitous, with the strongest level in placenta and kidney

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SGPP1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sgpp11 , 5 sphingosine-1-phosphate phosphatase 11, 5 82.79(n)1
    80.47(a)1
      12 (32.95 cM)5
    815351  NM_030750.31  NP_109675.11 
     757142485 
    chicken
    (Gallus gallus)
    Aves SGPP11 sphingosine-1-phosphate phosphatase 1 78.98(n)
    78.34(a)
      428918  XM_426472.4  XP_426472.4 
    lizard
    (Anolis carolinensis)
    Reptilia SGPP16
    sphingosine-1-phosphate phosphatase 1
    63(a)
    1 ↔ 1
    1(2115917-2139382)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.63212 Transcribed sequence with weak similarity to protein more 82.49(n)    AL967537.2 
    zebrafish
    (Danio rerio)
    Actinopterygii sgpp11 sphingosine-1-phosphate phosphatase 1 61.33(n)
    59.76(a)
      100003745  XM_001343183.4  XP_001343219.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0096751 AgaP_AGAP009675 48.64(n)
    39.88(a)
      1279065  XM_318734.3  XP_318734.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LCB3(YJL134W)4 Long-chain base-1-phosphate phosphatase with specificity more   --   10(158188-159417) 853307  NP_012401.1 


    ENSEMBL Gene Tree for SGPP1 (if available)
    TreeFam Gene Tree for SGPP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SGPP1 gene
    SGPP22  
    1 SIMAP similar gene for SGPP1 using alignment to 1 protein entry:     SGPP1_HUMAN:
    SGPP2

    Find genes that share paralogs with SGPP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SGPP1 (see all 942)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs74927851,2
    C,H--64150542(+) CAAAAT/CAAAAT 1 -- int15Minor allele frequency- C:0.00NS EA NA 416
    rs1468530501,2
    C--64150607(+) TCCTTA/GACATT 1 -- int10--------
    rs797681941,2
    C,F--64150691(+) TAAAAG/TAAATA 1 -- int11Minor allele frequency- T:0.04WA 118
    rs1163251011,2
    F--64150709(+) TTTTAC/TTAAAA 1 -- int11Minor allele frequency- T:0.01WA 118
    rs1406834771,2
    C--64150721(+) TACAAC/TGTTAG 1 -- int10--------
    rs1851351181,2
    --64150722(+) ACAATA/GTTAGA 1 -- int10--------
    rs171013561,2
    C,F,H--64150821(+) CAAAAC/TGCTTC 1 -- int18Minor allele frequency- T:0.02NA NS EA WA 678
    rs1921029371,2
    --64150868(+) ATTTTA/TAAAAT 1 -- int10--------
    rs171787951,2
    C,F,H--64150976(+) TAGCAT/CAGAAC 1 -- ut31 ese37Minor allele frequency- C:0.00NA NS EA 562
    rs1840891101,2
    C--64151057(+) TCAACA/GGGATA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SGPP1 (64150932 - 64194757 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SGPP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2748779CNV Deletion23290073
    dgv137n21CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SGPP1
    DNA2.0 Custom Variant and Variant Library Synthesis for SGPP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612826    OMIM disorders: --


    Find genes that share disorders with SGPP1           About GenesLikeMe

    Genetic Association Database (GAD): SGPP1
    Human Genome Epidemiology (HuGE) Navigator: SGPP1 (1 document)

    Export disorders for SGPP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SGPP1 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with SGPP1)
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    1. Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability. (PubMed id 12815058)1, 2, 9 Johnson K.R....Obeid L.M. (J. Biol. Chem. 2003)
    2. Genetic determinants of circulating sphingolipid concentrations in European populations. (PubMed id 19798445)1, 4 Hicks A.A....Campbell H. (PLoS Genet. 2009)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)
    6. Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death. (PubMed id 10859351)1, 3 Mandala S.M....Spiegel S. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    7. Identification and characterization of a novel human sphingosine-1- phosphate phosphohydrolase, hSPP2. (PubMed id 12411432)1, 9 Ogawa C.... Igarashi Y. (J. Biol. Chem. 2003)
    8. Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis. (PubMed id 15180992)1, 9 Le Stunff H....Spiegel S. (J. Biol. Chem. 2004)
    9. miRNA-95 mediates radioresistance in tumors by targeting the sphingolipid phosphatase SGPP1. (PubMed id 24145350)1 Huang X....Liu S.K. (Cancer Res. 2013)
    10. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PubMed id 22359512)1 Demirkan A....Schmitz G. (PLoS Genet. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81537 HGNC: 17720 AceView: SGPP1 Ensembl:ENSG00000126821 euGenes: HUgn81537
    ECgene: SGPP1 Kegg: 81537 H-InvDB: SGPP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SGPP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SGPP1 gene:
    Search GeneIP for patents involving SGPP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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