Aliases for SGPL1 Gene
External Ids for SGPL1 Gene
Previous GeneCards Identifiers for SGPL1 Gene
GeneCards Summary for SGPL1 Gene
SGPL1 (Sphingosine-1-Phosphate Lyase 1) is a Protein Coding gene. Diseases associated with SGPL1 include Nephrotic Syndrome 14 and Adrenal Insufficiency, Congenital, With 46Xy Sex Reversal, Partial Or Complete. Among its related pathways are Metabolism and Sphingolipid metabolism. GO annotations related to this gene include pyridoxal phosphate binding and sphinganine-1-phosphate aldolase activity.
UniProtKB/Swiss-Prot for SGPL1 Gene
Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.