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SGPL1 Gene

protein-coding   GIFtS: 66
GCID: GC10P072575

Sphingosine-1-Phosphate Lyase 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sphingosine-1-Phosphate Lyase 11 2     SPL 12 3
Sphingosine-1-Phosphate Aldolase2 3     SPL2 5
S1PL2 3     EC 4.1.2.273
hSPL2 3     KIAA12523
SP-Lyase 12 3     

External Ids:    HGNC: 108171   Entrez Gene: 88792   Ensembl: ENSG000001662247   OMIM: 6037295   UniProtKB: O954703   

Export aliases for SGPL1 gene to outside databases

Previous GC identifers: GC10P071360 GC10P071679 GC10P072468 GC10P071920 GC10P072245 GC10P066569


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SGPL1 Gene:
SGPL1 (sphingosine-1-phosphate lyase 1) is a protein-coding gene. Diseases associated with SGPL1 include pituitary adenoma, and atopic dermatitis. GO annotations related to this gene include pyridoxal phosphate binding and sphinganine-1-phosphate aldolase activity.

UniProtKB/Swiss-Prot: SGPL1_HUMAN, O95470
Function: Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and
phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis

Gene Wiki entry for SGPL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SGPL1 gene promoter:
         TBP   Egr-1   RelA   Meis-1b   GATA-1   MEF-2A   aMEF-2   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SGPL1 promoter sequence
   Search Chromatin IP Primers for SGPL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SGPL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q21

SGPL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SGPL1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P072575:  view genomic region     (about GC identifiers)

Start:
72,575,704 bp from pter      End:
72,640,946 bp from pter
Size:
65,243 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SGPL1_HUMAN, O95470 (See protein sequence)
Recommended Name: Sphingosine-1-phosphate lyase 1  
Size: 568 amino acids; 63524 Da
Cofactor: Pyridoxal phosphate (By similarity)
Sequence caution: Sequence=BAA86566.1; Type=Erroneous initiation;
Secondary accessions: B2RBD4 Q7Z732 Q9ULG8 Q9UN89

Explore the universe of human proteins at neXtProt for SGPL1: NX_O95470

Explore proteomics data for SGPL1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys114, Lys131, Lys263
  • Modification sites at PhosphoSitePlus

  • See SGPL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003892.2  
    ENSEMBL proteins: 
     ENSP00000362298   ENSP00000299297   ENSP00000386549  
    Reactome Protein details: O95470

    SGPL1 Human Recombinant Protein Products:

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    Novus Biologicals SGPL1 Lysates
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    Cloud-Clone Corp. Proteins for SGPL1

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    ThermoFisher Antibodies for SGPL1
    LSBio Antibodies in human, mouse, rat for SGPL1

    SGPL1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SGPL1
    Cloud-Clone Corp. CLIAs for SGPL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR002129 PyrdxlP-dep_de-COase
     IPR015424 PyrdxlP-dep_Trfase
     IPR015421 PyrdxlP-dep_Trfase_major_sub1

    Graphical View of Domain Structure for InterPro Entry O95470

    ProtoNet protein and cluster: O95470

    UniProtKB/Swiss-Prot: SGPL1_HUMAN, O95470
    Similarity: Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily


    SGPL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SGPL1_HUMAN, O95470
    Function: Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and
    phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis
    Catalytic activity: Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde

         Genatlas biochemistry entry for SGPL1:
    sphingosine-1-phosphate lyase 1,pyridoxal dependent,involved in the proliferative signal transduction pathways

         Enzyme Number (IUBMB): EC 4.1.2.271

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008117sphinganine-1-phosphate aldolase activity NAS11018465
    GO:0016831carboxy-lyase activity IEA--
    GO:0030170pyridoxal phosphate binding IEA--
         
    SGPL1 for ontologies           About GeneDecksing


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 7 alleles(MGI details for Sgpl1) (see all 17):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     muscle  no phenotypic analysis  normal  renal/urinary system  reproductive system 

    SGPL1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sgpl1tm1.2Npa for SGPL1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SGPL1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SGPL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SGPL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SGPL1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SGPL1:
    hsa-mir-155-5p (MIRT020949), hsa-mir-1226-3p (MIRT036509), hsa-mir-125b-5p (MIRT002370), hsa-mir-7-5p (MIRT025931), hsa-mir-124-3p (MIRT023023)

    Block miRNA regulation of human, mouse, rat SGPL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SGPL1 (see all 37):
    hsa-miR-3678-3p hsa-miR-607 hsa-miR-624* hsa-miR-218 hsa-miR-124 hsa-miR-506 hsa-miR-626 hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidSGPL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SGPL1
    Predesigned siRNA for gene silencing in human, mouse, rat SGPL1

    Gene Editing
    Products:
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    GenScript: all cDNA clones in your preferred vector: SGPL1 (NM_003901)
    Sino Biological Human cDNA Clone for SGPL1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGPL1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGPL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SGPL1_HUMAN, O95470: Endoplasmic reticulum membrane; Single-pass type III membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol2
    golgi apparatus2
    nucleus2
    extracellular1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA14570870
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0030176integral component of endoplasmic reticulum membrane NAS11018465

    SGPL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SGPL1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Sphingolipid metabolism
    Sphingolipid metabolism0.61
    Sphingolipid de novo biosynthesis0.46
    Sphingolipid metabolism0.61
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    3S1P3 pathway
    Sphingosine 1-phosphate (S1P) pathway0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SGPL1
        Sphingosine 1-phosphate (S1P) pathway


    1 Reactome Pathway for SGPL1
        Sphingolipid de novo biosynthesis


    2 Kegg Pathways  (Kegg details for SGPL1):
        Sphingolipid metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: SGPL1_HUMAN, O95470
    Pathway: Lipid metabolism; sphingolipid metabolism


    SGPL1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including SGPL1: 

              Notch Signaling Targets in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SGPL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SGPL1 (O954701, 3 ENSP000003622984) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TMEM173Q86WV61, 3, ENSP000003312884EBI-1046170,EBI-2800345 I2D: score=1 STRING: ENSP00000331288
    PISDQ9UG563, ENSP000002660954I2D: score=1 STRING: ENSP00000266095
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    SPHK2Q9NRA03, ENSP000002452224I2D: score=1 STRING: ENSP00000245222
    SPTLC2O152703, ENSP000002164844I2D: score=1 STRING: ENSP00000216484
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001553luteinization IEA--
    GO:0001570vasculogenesis IEA--
    GO:0001822kidney development IEA--
    GO:0006665sphingolipid metabolic process TAS--
    GO:0006672ceramide metabolic process IDA14570870

    SGPL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SGPL1

    Selected HMDB Compounds for SGPL1 (see all 38)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cer(d18:0/12:0) ----
    Cer(d18:0/14:0) ----
    Cer(d18:0/16:0) ----
    Cer(d18:0/18:0) ----
    Cer(d18:0/18:1(11Z)) ----
    Cer(d18:0/18:1(9Z)) ----
    Cer(d18:0/20:0) ----
    Cer(d18:0/22:0) ----
    Cer(d18:0/22:1(13Z)) ----
    Cer(d18:0/23:0) ----

    1 DrugBank Compound for SGPL1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetcofactor11377878 15522238

    1 Novoseek inferred chemical compound relationship for SGPL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sphingosine 59.6 1 15258913 (1)



    SGPL1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SGPL1 gene: 
    NM_003901.3  

    Unigene Cluster for SGPL1:

    Sphingosine-1-phosphate lyase 1
    Hs.499984  [show with all ESTs]
    Unigene Representative Sequence: NM_003901
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486993(uc001jrl.2) ENST00000373202(uc001jrm.3 uc009xqk.3)
    ENST00000299297 ENST00000409118
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat SGPL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SGPL1 (see all 37):
    hsa-miR-3678-3p hsa-miR-607 hsa-miR-624* hsa-miR-218 hsa-miR-124 hsa-miR-506 hsa-miR-626 hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidSGPL1 3' UTR sequence
    Inhib. RNA
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    Clone
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    OriGene ORF clones in mouse, rat for SGPL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SGPL1 (NM_003901)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGPL1
    Primer
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    OriGene qPCR primer pairs and template standards for SGPL1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SGPL1
      QuantiTect SYBR Green Assays in human, mouse, rat SGPL1
      QuantiFast Probe-based Assays in human, mouse, rat SGPL1

    Additional mRNA sequence: 

    AB033078.1 AF144638.1 AJ011304.2 AK023873.1 AK308610.1 AK314615.1 BC031338.1 BC041567.1 
    BC051238.1 BC052991.1 BC068061.1 

    12 DOTS entries:

    DT.216906  DT.99934933  DT.100789416  DT.100010662  DT.91748919  DT.121264661  DT.65284746  DT.70103051 
    DT.95308624  DT.95214309  DT.91744923  DT.97776403 

    Selected AceView cDNA sequences (see all 259):

    CA307922 AA458506 N59392 BU626117 BE139630 AI301639 AA699330 AI091626 
    AI656172 BQ953703 BX499484 BU622668 AW148814 AW273244 BQ224779 BM703055 
    BM678208 AU118779 R84511 BU608120 AA235660 T08353 BM955766 BX957002 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SGPL1 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^
    SP1:                                -     -     -     -           -     -                                         -                             -           -   
    SP2:                                                              -     -                                         -                                             
    SP3:                          -     -     -     -     -           -     -                                         -                                             
    SP4:                          -     -     -     -     -           -     -                                         -                                             
    SP5:                                -     -     -     -           -     -                                                                                       

    ExUns: 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for SGPL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SGPL1 expression in normal human tissues (normalized intensities)      SGPL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTATTATT
    SGPL1 Expression
    About this image


    SGPL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Limb (Muscoskeletal System)
             Limb Bud
     
     Thymus (Hematopoietic System)
             Thymus
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Brain (Nervous System)
             Cerebral Cortex
    SGPL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SGPL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.499984

    UniProtKB/Swiss-Prot: SGPL1_HUMAN, O95470
    Tissue specificity: Found in liver and kidney

        Pathway & Disease-focused RT2 Profiler PCR Array including SGPL1: 
              Notch Signaling Targets in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGPL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SGPL1 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sgpl11 , 5 sphingosine phosphate lyase 11, 5 84.8(n)1
    84.68(a)1
      10 (32.14 cM)5
    203971  NM_009163.31  NP_033189.21 
     610986425 
    chicken
    (Gallus gallus)
    Aves SGPL11 sphingosine-1-phosphate lyase 1 67.98(n)
    69.11(a)
      423714  NM_001007946.2  NP_001007947.1 
    lizard
    (Anolis carolinensis)
    Reptilia SGPL16
    sphingosine-1-phosphate lyase 1
    68(a)
    1 ↔ 1
    3(50344342-50402950)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.101022 Transcribed sequence with moderate similarity to protein more 74.27(n)    BX693739.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sgpl11 sphingosine-1-phosphate lyase 1 65.95(n)
    64.45(a)
      100037312  NM_001089469.1  NP_001082938.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sply1 , 3 sphinganine-1-phosphate aldolase3
    Sphingosine-1-phosphate lyase1
    49(a)3
    55.64(n)1
    50(a)1
      53F83
    460591  NM_166215.11  NP_725652.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y66H1B.43
    tag-381
    tag-381 43(a)
    (best of 3)3
    49.31(n)1
    39.2(a)1
      IV(380018-383179)3
    1818591  NM_072971.41  NP_505372.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DPL1(YDR294C)4
    DPL11
    Dihydrosphingosine phosphate lyase, regulates intracellular more4
    DPL11
    52.6(n)1
    42.83(a)1
      4(1052228-1050459)4
    8518881, 4  NP_010580.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons DPL11 DPL1 50.55(n)
    44.32(a)
      839691  NM_102563.3  NP_174119.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g01009001 Os01g0100900 49.11(n)
    42.59(a)
      4326459  NM_001048275.2  NP_001041740.2 


    ENSEMBL Gene Tree for SGPL1 (if available)
    TreeFam Gene Tree for SGPL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SGPL1 (see all 1355)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1501681651,2
    --72573712(+) CACACA/TCACAG 1 -- us2k10--------
    rs1860552781,2
    --72573732(+) GGCTCA/GGAGAG 1 -- us2k10--------
    rs1386293871,2
    --72573808(+) CTGGAC/TCTCAG 1 -- us2k10--------
    rs1157894291,2
    F--72573872(+) GACCCC/TTCTAG 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs27911801,2
    C,F,H--72573879(+) CTAGCT/CCTACC 1 -- us2k114Minor allele frequency- C:0.01NA WA CSA EA 379
    rs1164809021,2
    F--72574110(+) ATGTAA/GAGGTG 1 -- us2k11Minor allele frequency- G:0.06WA 118
    rs1155230001,2
    --72574142(+) GCAAGG/TATCAG 1 -- us2k10--------
    rs27911811,2
    C,H--72574170(+) GTTTGT/AGCATC 1 -- us2k112Minor allele frequency- A:0.03NA WA CSA 140
    rs1888626951,2
    --72574318(+) GAGGTA/GTGCAG 1 -- us2k10--------
    rs26303391,2
    C,F,A,H--72574353(-) CTTCTG/CCTTTA 1 -- us2k1 tfbs316Minor allele frequency- C:0.14NS EA NA WA CSA 1324

    HapMap Linkage Disequilibrium report for SGPL1 (72575704 - 72640946 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SGPL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665625CNV Deletion23128226
    esv1086437CNV Insertion17803354
    esv268853CNV Insertion20981092
    nsv526539CNV Gain19592680
    nsv517453CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SGPL1
    DNA2.0 Custom Variant and Variant Library Synthesis for SGPL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603729    OMIM disorders: --

    13 diseases for SGPL1:    About MalaCards
    pituitary adenoma    atopic dermatitis    adenoma    dermatitis
    influenza    tuberculosis    alzheimer's disease    lung cancer
    prostate cancer    prostatitis    endotheliitis    malaria
    cerebritis


    SGPL1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for SGPL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenoma 23.1 1 17361098 (1)
    colon cancer 22.8 2 17361098 (1), 17090686 (1)
    cancer 5.32 6 17416206 (2), 19934311 (1), 19534571 (1), 20215862 (1)
    tumors 0 3 19934311 (1), 17090686 (1)

    Genetic Association Database (GAD): SGPL1
    Human Genome Epidemiology (HuGE) Navigator: SGPL1 (2 documents)

    Export disorders for SGPL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SGPL1 gene, integrated from 10 sources (see all 57):
    (articles sorted by number of sources associating them with SGPL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer. (PubMed id 17090686)1, 3, 9 Oskouian B....Saba J.D. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    2. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PubMed id 16777052)1, 2, 9 Zhan X. and Desiderio D.M. (Anal. Biochem. 2006)
    3. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. (PubMed id 17373700)1, 4 Morgan A.R....Williams J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. (PubMed id 14570870)1, 2 Reiss U.... Saba J.D. (J. Biol. Chem. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22. (PubMed id 11018465)1, 2 Van Veldhoven P.P....Brys V. (Biochim. Biophys. Acta 2000)
    9. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    10. Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast. (PubMed id 9464245)1, 3 Zhou J. and Saba J.D. (Biochem. Biophys. Res. Commun. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8879 HGNC: 10817 AceView: SGPL1 Ensembl:ENSG00000166224 euGenes: HUgn8879
    ECgene: SGPL1 Kegg: 8879 H-InvDB: SGPL1

    (According to HUGE)
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    HUGE: KIAA1252

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SGPL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SGPL1 gene:
    Search GeneIP for patents involving SGPL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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