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Aliases for SGPL1 Gene

Aliases for SGPL1 Gene

  • Sphingosine-1-Phosphate Lyase 1 2 3
  • Sphingosine-1-Phosphate Aldolase 3 4
  • SP-Lyase 1 3 4
  • SPL 1 3 4
  • S1PL 3 4
  • HSPL 3 4
  • SPL 3 6
  • EC 4.1.2.27 4
  • KIAA1252 4

External Ids for SGPL1 Gene

Summaries for SGPL1 Gene

GeneCards Summary for SGPL1 Gene

SGPL1 (Sphingosine-1-Phosphate Lyase 1) is a Protein Coding gene. Among its related pathways are Sphingolipid metabolism and Sphingolipid metabolism. GO annotations related to this gene include pyridoxal phosphate binding and sphinganine-1-phosphate aldolase activity.

UniProtKB/Swiss-Prot for SGPL1 Gene

  • Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.

Gene Wiki entry for SGPL1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGPL1 Gene

Genomics for SGPL1 Gene

Genomic Location for SGPL1 Gene

Start:
70,815,948 bp from pter
End:
70,881,189 bp from pter
Size:
65,242 bases
Orientation:
Plus strand

Genomic View for SGPL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SGPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGPL1 Gene

Regulatory Elements for SGPL1 Gene

Proteins for SGPL1 Gene

  • Protein details for SGPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95470-SGPL1_HUMAN
    Recommended name:
    Sphingosine-1-phosphate lyase 1
    Protein Accession:
    O95470
    Secondary Accessions:
    • B2RBD4
    • Q7Z732
    • Q9ULG8
    • Q9UN89

    Protein attributes for SGPL1 Gene

    Size:
    568 amino acids
    Molecular mass:
    63524 Da
    Cofactor:
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=BAA86566.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SGPL1 Gene

neXtProt entry for SGPL1 Gene

Proteomics data for SGPL1 Gene at MOPED

Post-translational modifications for SGPL1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys114, Lys131, and Lys263

Other Protein References for SGPL1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SGPL1 Gene

Domains for SGPL1 Gene

Protein Domains for SGPL1 Gene

UniProtKB/Swiss-Prot:

SGPL1_HUMAN
Family:
  • Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.:
    • O95470
genes like me logo Genes that share domains with SGPL1: view

No data available for Gene Families for SGPL1 Gene

Function for SGPL1 Gene

Molecular function for SGPL1 Gene

GENATLAS Biochemistry: sphingosine-1-phosphate lyase 1,pyridoxal dependent,involved in the proliferative signal transduction pathways
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=5.2 uM for sphingosine 1-phosphate {ECO:0000269 PubMed:24809814};
UniProtKB/Swiss-Prot CatalyticActivity: Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.
UniProtKB/Swiss-Prot Function: Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.

Enzyme Numbers (IUBMB) for SGPL1 Gene

Gene Ontology (GO) - Molecular Function for SGPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21903422
GO:0008117 sphinganine-1-phosphate aldolase activity NAS 11018465
GO:0016831 carboxy-lyase activity IEA --
GO:0030170 pyridoxal phosphate binding IEA --
genes like me logo Genes that share ontologies with SGPL1: view
genes like me logo Genes that share phenotypes with SGPL1: view

Animal Models for SGPL1 Gene

MGI Knock Outs for SGPL1:

No data available for Transcription Factor Targeting and HOMER Transcription for SGPL1 Gene

Localization for SGPL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SGPL1 Gene

Endoplasmic reticulum membrane; Single-pass type III membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SGPL1 Gene COMPARTMENTS Subcellular localization image for SGPL1 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
golgi apparatus 2
nucleus 2
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SGPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0030176 integral component of endoplasmic reticulum membrane NAS 11018465
genes like me logo Genes that share ontologies with SGPL1: view

Pathways for SGPL1 Gene

genes like me logo Genes that share pathways with SGPL1: view

Pathways by source for SGPL1 Gene

UniProtKB/Swiss-Prot O95470-SGPL1_HUMAN

  • Pathway: Lipid metabolism; sphingolipid metabolism

Gene Ontology (GO) - Biological Process for SGPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001553 luteinization IEA --
GO:0001570 vasculogenesis IEA --
GO:0001822 kidney development IEA --
GO:0006631 fatty acid metabolic process IDA 24809814
GO:0006665 sphingolipid metabolic process TAS --
genes like me logo Genes that share ontologies with SGPL1: view

Compounds for SGPL1 Gene

(38) HMDB Compounds for SGPL1 Gene

Compound Synonyms Cas Number PubMed IDs
Cer(d18:0/12:0)
Not Available
Cer(d18:0/14:0)
Not Available
Cer(d18:0/16:0)
Not Available
Cer(d18:0/18:0)
Not Available
Cer(d18:0/18:1(11Z))
Not Available

(1) Drugbank Compounds for SGPL1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Pyridoxal Phosphate
  • Codecarboxylase
54-47-7 target cofactor

(1) Novoseek inferred chemical compound relationships for SGPL1 Gene

Compound -log(P) Hits PubMed IDs
sphingosine 59.6 1
genes like me logo Genes that share compounds with SGPL1: view

Transcripts for SGPL1 Gene

Unigene Clusters for SGPL1 Gene

Sphingosine-1-phosphate lyase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SGPL1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^
SP1: - - - - - - - - -
SP2: - - -
SP3: - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - -
SP7: - - -
SP8: - - - - - - -
SP9: - - - - -
SP10: - - - - -
SP11: -
SP12: -
SP13: - - - -

ExUns: 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for SGPL1 Gene

GeneLoc Exon Structure for
SGPL1
ECgene alternative splicing isoforms for
SGPL1

Expression for SGPL1 Gene

mRNA expression in normal human tissues for SGPL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SGPL1 Gene

SOURCE GeneReport for Unigene cluster for SGPL1 Gene Hs.499984

mRNA Expression by UniProt/SwissProt for SGPL1 Gene

O95470-SGPL1_HUMAN
Tissue specificity: Found in liver and kidney.
genes like me logo Genes that share expressions with SGPL1: view

Orthologs for SGPL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SGPL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SGPL1 36
  • 99.71 (n)
  • 99.82 (a)
SGPL1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SGPL1 36
  • 87.5 (n)
  • 91.02 (a)
SGPL1 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SGPL1 36
  • 89.61 (n)
  • 93.31 (a)
SGPL1 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sgpl1 36
  • 84.8 (n)
  • 84.68 (a)
Sgpl1 16
Sgpl1 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SGPL1 37
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SGPL1 37
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sgpl1 36
  • 85.27 (n)
  • 85.56 (a)
chicken
(Gallus gallus)
Aves SGPL1 36
  • 67.98 (n)
  • 69.11 (a)
lizard
(Anolis carolinensis)
Reptilia SGPL1 37
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sgpl1 36
  • 67.22 (n)
  • 67.59 (a)
Str.10102 36
zebrafish
(Danio rerio)
Actinopterygii sgpl1 36
  • 65.95 (n)
  • 64.45 (a)
sgpl1 37
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001724 36
  • 54.93 (n)
  • 51.17 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sply 36
  • 55.64 (n)
  • 50 (a)
Sply 37
  • 48 (a)
OneToOne
Sply 38
  • 49 (a)
worm
(Caenorhabditis elegans)
Secernentea spl-1 37
  • 42 (a)
OneToMany
tag-38 36
  • 49.31 (n)
  • 39.2 (a)
tag-38 37
  • 38 (a)
OneToMany
Y104H12D.3 37
  • 31 (a)
OneToMany
Y66H1B.4 38
  • 43 (a)
Y104H12D.3 38
  • 40 (a)
B0222.4 38
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DPL1 36
  • 52.6 (n)
  • 42.83 (a)
DPL1 37
  • 35 (a)
OneToOne
DPL1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C10505g 36
  • 50.6 (n)
  • 42.57 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons DPL1 36
  • 50.55 (n)
  • 44.32 (a)
rice
(Oryza sativa)
Liliopsida Os01g0100900 36
  • 49.11 (n)
  • 42.59 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06761 36
  • 51.96 (n)
  • 46.9 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13999 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9336 37
  • 51 (a)
OneToOne
Species with no ortholog for SGPL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SGPL1 Gene

ENSEMBL:
Gene Tree for SGPL1 (if available)
TreeFam:
Gene Tree for SGPL1 (if available)

Paralogs for SGPL1 Gene

No data available for Paralogs for SGPL1 Gene

Variants for SGPL1 Gene

Sequence variations from dbSNP and Humsavar for SGPL1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs2881 -- 70,880,043(+) TTTCA(A/G)TGCTC utr-variant-3-prime
rs827232 -- 70,846,549(-) agtgg(A/G)gtgat intron-variant
rs827233 -- 70,843,984(-) TACTC(A/C)TCTCT intron-variant
rs827234 -- 70,843,903(-) ATTAC(A/G)GACAC intron-variant
rs827235 -- 70,842,056(-) GTATC(A/G)GGTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SGPL1 Gene

Variant ID Type Subtype PubMed ID
nsv517453 CNV Gain+Loss 19592680
esv2665625 CNV Deletion 23128226
nsv526539 CNV Gain 19592680
esv268853 CNV Insertion 20981092
esv1086437 CNV Insertion 17803354

Relevant External Links for SGPL1 Gene

HapMap Linkage Disequilibrium report
SGPL1

Disorders for SGPL1 Gene

(4) Novoseek inferred disease relationships for SGPL1 Gene

Disease -log(P) Hits PubMed IDs
adenoma 23.1 1
colon cancer 22.8 2
cancer 5.32 5
tumors 0 2

Relevant External Links for SGPL1

Genetic Association Database (GAD)
SGPL1
Human Genome Epidemiology (HuGE) Navigator
SGPL1
genes like me logo Genes that share disorders with SGPL1: view

No data available for UniProtKB/Swiss-Prot for SGPL1 Gene

Publications for SGPL1 Gene

  1. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PMID: 16777052) Zhan X. … Desiderio D.M. (Anal. Biochem. 2006) 3 4 23
  2. Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer. (PMID: 17090686) Oskouian B. … Saba J.D. (Proc. Natl. Acad. Sci. U.S.A. 2006) 2 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 49
  5. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. (PMID: 17373700) Morgan A.R. … Williams J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 49

Products for SGPL1 Gene

Sources for SGPL1 Gene

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