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Aliases for SGPL1 Gene

Aliases for SGPL1 Gene

  • Sphingosine-1-Phosphate Lyase 1 2 3 5
  • Sphingosine-1-Phosphate Aldolase 3 4
  • SP-Lyase 1 3 4
  • SPL 1 3 4
  • S1PL 3 4
  • HSPL 3 4
  • EC 4.1.2.27 4
  • KIAA1252 4
  • SPL 3

External Ids for SGPL1 Gene

Previous GeneCards Identifiers for SGPL1 Gene

  • GC10P071360
  • GC10P071679
  • GC10P072468
  • GC10P071920
  • GC10P072245
  • GC10P072575
  • GC10P066569

Summaries for SGPL1 Gene

GeneCards Summary for SGPL1 Gene

SGPL1 (Sphingosine-1-Phosphate Lyase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Sphingolipid metabolism. GO annotations related to this gene include pyridoxal phosphate binding and sphinganine-1-phosphate aldolase activity.

UniProtKB/Swiss-Prot for SGPL1 Gene

  • Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.

Gene Wiki entry for SGPL1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGPL1 Gene

Genomics for SGPL1 Gene

Regulatory Elements for SGPL1 Gene

Enhancers for SGPL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SGPL1 on UCSC Golden Path with GeneCards custom track

Promoters for SGPL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SGPL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SGPL1 Gene

Chromosome:
10
Start:
70,815,948 bp from pter
End:
70,881,189 bp from pter
Size:
65,242 bases
Orientation:
Plus strand

Genomic View for SGPL1 Gene

Genes around SGPL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGPL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGPL1 Gene

Proteins for SGPL1 Gene

  • Protein details for SGPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95470-SGPL1_HUMAN
    Recommended name:
    Sphingosine-1-phosphate lyase 1
    Protein Accession:
    O95470
    Secondary Accessions:
    • B2RBD4
    • Q7Z732
    • Q9ULG8
    • Q9UN89

    Protein attributes for SGPL1 Gene

    Size:
    568 amino acids
    Molecular mass:
    63524 Da
    Cofactor:
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=BAA86566.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SGPL1 Gene

neXtProt entry for SGPL1 Gene

Proteomics data for SGPL1 Gene at MOPED

Post-translational modifications for SGPL1 Gene

  • Ubiquitination at Lys 114, Lys 131, and Lys 263
  • Modification sites at PhosphoSitePlus

Other Protein References for SGPL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for SGPL1

No data available for DME Specific Peptides for SGPL1 Gene

Domains & Families for SGPL1 Gene

Protein Domains for SGPL1 Gene

Suggested Antigen Peptide Sequences for SGPL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95470

UniProtKB/Swiss-Prot:

SGPL1_HUMAN :
  • Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.
Family:
  • Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.
genes like me logo Genes that share domains with SGPL1: view

No data available for Gene Families for SGPL1 Gene

Function for SGPL1 Gene

Molecular function for SGPL1 Gene

GENATLAS Biochemistry:
sphingosine-1-phosphate lyase 1,pyridoxal dependent,involved in the proliferative signal transduction pathways
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=5.2 uM for sphingosine 1-phosphate {ECO:0000269 PubMed:24809814};
UniProtKB/Swiss-Prot CatalyticActivity:
Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.
UniProtKB/Swiss-Prot Function:
Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.

Enzyme Numbers (IUBMB) for SGPL1 Gene

genes like me logo Genes that share phenotypes with SGPL1: view

Animal Models for SGPL1 Gene

MGI Knock Outs for SGPL1:

Animal Model Products

miRNA for SGPL1 Gene

miRTarBase miRNAs that target SGPL1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SGPL1 Gene

Localization for SGPL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SGPL1 Gene

Endoplasmic reticulum membrane; Single-pass type III membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SGPL1 Gene COMPARTMENTS Subcellular localization image for SGPL1 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
golgi apparatus 2
nucleus 2
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SGPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030176 integral component of endoplasmic reticulum membrane NAS 11018465
genes like me logo Genes that share ontologies with SGPL1: view

Pathways & Interactions for SGPL1 Gene

genes like me logo Genes that share pathways with SGPL1: view

Pathways by source for SGPL1 Gene

UniProtKB/Swiss-Prot O95470-SGPL1_HUMAN

  • Pathway: Lipid metabolism; sphingolipid metabolism.

Gene Ontology (GO) - Biological Process for SGPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001570 vasculogenesis IEA --
GO:0001822 kidney development IEA --
GO:0006631 fatty acid metabolic process IDA 24809814
GO:0006672 ceramide metabolic process IDA 14570870
GO:0006807 nitrogen compound metabolic process IEA --
genes like me logo Genes that share ontologies with SGPL1: view

No data available for SIGNOR curated interactions for SGPL1 Gene

Drugs & Compounds for SGPL1 Gene

(5) Drugs for SGPL1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hexadecanal Experimental Pharma 0
O-Phosphoethanolamine Experimental Pharma 0
Pyridoxal Phosphate Nutra Target, cofactor 14
Sphingosine-1-phosphate Pharma Full agonist, Agonist Endogenous agonist at S1P1-5 0

(31) Additional Compounds for SGPL1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cer(d18:0/12:0)
Cer(d18:0/14:0)
Cer(d18:0/16:0)
Cer(d18:0/18:0)
Cer(d18:0/18:1(11Z))
genes like me logo Genes that share compounds with SGPL1: view

Transcripts for SGPL1 Gene

Unigene Clusters for SGPL1 Gene

Sphingosine-1-phosphate lyase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SGPL1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^
SP1: - - - - - - - - -
SP2: - - -
SP3: - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - -
SP7: - - -
SP8: - - - - - - -
SP9: - - - - -
SP10: - - - - -
SP11: -
SP12: -
SP13: - - - -

ExUns: 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for SGPL1 Gene

GeneLoc Exon Structure for
SGPL1
ECgene alternative splicing isoforms for
SGPL1

Expression for SGPL1 Gene

mRNA expression in normal human tissues for SGPL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SGPL1 Gene

This gene is overexpressed in Nasal epithelium (22.5) and Lymph node (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SGPL1 Gene



SOURCE GeneReport for Unigene cluster for SGPL1 Gene Hs.499984

mRNA Expression by UniProt/SwissProt for SGPL1 Gene

O95470-SGPL1_HUMAN
Tissue specificity: Found in liver and kidney.
genes like me logo Genes that share expression patterns with SGPL1: view

Protein tissue co-expression partners for SGPL1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for SGPL1 Gene

Orthologs for SGPL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SGPL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SGPL1 35
  • 87.5 (n)
  • 91.02 (a)
SGPL1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SGPL1 35
  • 89.61 (n)
  • 93.31 (a)
SGPL1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sgpl1 35
  • 84.8 (n)
  • 84.68 (a)
Sgpl1 16
Sgpl1 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SGPL1 35
  • 99.71 (n)
  • 99.82 (a)
SGPL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sgpl1 35
  • 85.27 (n)
  • 85.56 (a)
oppossum
(Monodelphis domestica)
Mammalia SGPL1 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SGPL1 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves SGPL1 35
  • 67.98 (n)
  • 69.11 (a)
lizard
(Anolis carolinensis)
Reptilia SGPL1 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sgpl1 35
  • 67.22 (n)
  • 67.59 (a)
Str.10102 35
zebrafish
(Danio rerio)
Actinopterygii sgpl1 35
  • 65.95 (n)
  • 64.45 (a)
sgpl1 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sply 37
  • 49 (a)
Sply 35
  • 55.64 (n)
  • 50 (a)
Sply 36
  • 48 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001724 35
  • 54.93 (n)
  • 51.17 (a)
worm
(Caenorhabditis elegans)
Secernentea B0222.4 37
  • 38 (a)
Y104H12D.3 37
  • 40 (a)
Y66H1B.4 37
  • 43 (a)
tag-38 35
  • 49.31 (n)
  • 39.2 (a)
spl-1 36
  • 42 (a)
OneToMany
tag-38 36
  • 38 (a)
OneToMany
Y104H12D.3 36
  • 31 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C10505g 35
  • 50.6 (n)
  • 42.57 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DPL1 35
  • 52.6 (n)
  • 42.83 (a)
DPL1 36
  • 35 (a)
OneToOne
DPL1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons DPL1 35
  • 50.55 (n)
  • 44.32 (a)
rice
(Oryza sativa)
Liliopsida Os01g0100900 35
  • 49.11 (n)
  • 42.59 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13999 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06761 35
  • 51.96 (n)
  • 46.9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9336 36
  • 51 (a)
OneToOne
Species with no ortholog for SGPL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SGPL1 Gene

ENSEMBL:
Gene Tree for SGPL1 (if available)
TreeFam:
Gene Tree for SGPL1 (if available)

Paralogs for SGPL1 Gene

No data available for Paralogs for SGPL1 Gene

Variants for SGPL1 Gene

Sequence variations from dbSNP and Humsavar for SGPL1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs12770335 - 70,844,506(+) TGGAA(G/T)TATAC reference, missense, utr-variant-5-prime
rs1485998 -- 70,852,727(-) CGCGC(A/G)CACAC intron-variant
rs2881 -- 70,880,043(+) TTTCA(A/G)TGCTC utr-variant-3-prime
rs1591917 -- 70,831,188(+) tttca(C/T)tggaa intron-variant
rs1683852 -- 70,853,363(-) AGAAC(A/G)CCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SGPL1 Gene

Variant ID Type Subtype PubMed ID
nsv517453 CNV Gain+Loss 19592680
esv2665625 CNV Deletion 23128226
nsv526539 CNV Gain 19592680
esv268853 CNV Insertion 20981092
esv1086437 CNV Insertion 17803354

Variation tolerance for SGPL1 Gene

Residual Variation Intolerance Score: 8.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.23; 62.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SGPL1 Gene

HapMap Linkage Disequilibrium report
SGPL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SGPL1 Gene

Disorders for SGPL1 Gene

Relevant External Links for SGPL1

Genetic Association Database (GAD)
SGPL1
Human Genome Epidemiology (HuGE) Navigator
SGPL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SGPL1

No disorders were found for SGPL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SGPL1 Gene

Publications for SGPL1 Gene

  1. Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer. (PMID: 17090686) Oskouian B. … Saba J.D. (Proc. Natl. Acad. Sci. U.S.A. 2006) 2 3 23 67
  2. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PMID: 16777052) Zhan X. … Desiderio D.M. (Anal. Biochem. 2006) 3 23
  3. Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast. (PMID: 9464245) Zhou J. … Saba J.D. (Biochem. Biophys. Res. Commun. 1998) 2 3
  4. Dissociation of SHP-1 from spinophilin during platelet activation exposes an inhibitory binding site for protein phosphatase-1 (PP1). (PMID: 25785436) Ma P. … Brass L.F. (PLoS ONE 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for SGPL1 Gene

Sources for SGPL1 Gene

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