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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SGPL1 Gene

protein-coding   GIFtS: 62
GCID: GC10P072575

sphingosine-1-phosphate lyase 1

 Explore 10 diseases affiliated with
SGPL1 via our new
 Human Malady Compendium 
Biological research products
for SGPL1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Sphingosine-1-Phosphate Lyase 11 2     SP-Lyase 12 3
SPL1 2 5     SPL 12 3
Sphingosine-1-Phosphate Aldolase2 3     EC 4.1.2.273
S1PL2 3     KIAA12523
HSPL1     

External Ids:    HGNC: 108171   Entrez Gene: 88792   Ensembl: ENSG000001662247   OMIM: 6037295   UniProtKB: O954703   

Export aliases for SGPL1 gene to outside databases

Previous GC identifers: GC10P071360 GC10P071679 GC10P072468 GC10P071920 GC10P072245 GC10P066569


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SGPL1_HUMAN, O95470
Function: Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and
phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis

Gene Wiki entry for SGPL1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SGPL1 gene promoter:
         TBP   Egr-1   RelA   Meis-1b   GATA-1   MEF-2A   aMEF-2   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SGPL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SGPL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SGPL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q21

SGPL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SGPL1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P072575:  view genomic region     (about GC identifiers)

Start:
72,575,704 bp from pter      End:
72,640,946 bp from pter
Size:
65,243 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SGPL1_HUMAN, O95470 (See protein sequence)
Recommended Name: Sphingosine-1-phosphate lyase 1  
Size: 568 amino acids; 63524 Da
Cofactor: Pyridoxal phosphate (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Single-pass type III membrane protein
Sequence caution: Sequence=BAA86566.1; Type=Erroneous initiation;
Secondary accessions: B2RBD4 Q7Z732 Q9ULG8 Q9UN89

Explore the universe of human proteins at neXtProt for SGPL1: NX_O95470

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95470

  • SGPL1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003892.2  
    ENSEMBL proteins: 
     ENSP00000362298   ENSP00000299297   ENSP00000386549  
    Reactome Protein details: O95470
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SGPL1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0030176integral to endoplasmic reticulum membrane NAS11018465


    SGPL1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SGPL1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR002129 PyrdxlP-dep_de-COase
     IPR015424 PyrdxlP-dep_Trfase
     IPR015421 PyrdxlP-dep_Trfase_major_sub1

    Graphical View of Domain Structure for InterPro Entry O95470

    ProtoNet protein and cluster: O95470

    UniProtKB/Swiss-Prot: SGPL1_HUMAN, O95470
    Similarity: Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SGPL1_HUMAN, O95470
    Function: Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and
    phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis
    Catalytic activity: Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde

         Genatlas biochemistry entry for SGPL1:
    sphingosine-1-phosphate lyase 1,pyridoxal dependent,involved in the proliferative signal transduction pathways

    Enzyme Number (IUBMB): EC 4.1.2.271

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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008117sphinganine-1-phosphate aldolase activity NAS11018465
    GO:0016831carboxy-lyase activity IEA--
    GO:0030170pyridoxal phosphate binding IEA--


    SGPL1 for ontologies           About GeneDecksing


    Animal Models:
         15/17 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Sgpl1) (see all 17):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     muscle  no phenotypic analysis  normal  renal/urinary system  reproductive system 

    SGPL1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Sphingolipid metabolism
    Sphingolipid metabolism1.00
    Sphingolipid de novo biosynthesis0.46
    Sphingolipid metabolism0.54
    2Metabolism
    Metabolism1.00
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.38
    3S1P3 pathway
    Sphingosine 1-phosphate (S1P) pathway0.40

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for SGPL1 
        Sphingosine 1-phosphate (S1P) pathway

    4        Reactome Pathways for SGPL1
        Sphingolipid metabolism
    Metabolism
    Metabolism of lipids and lipoproteins
    Sphingolipid de novo biosynthesis


    2         Kegg Pathways  (Kegg details for SGPL1):
        Sphingolipid metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: SGPL1_HUMAN, O95470
    Pathway: Lipid metabolism; sphingolipid metabolism


    SGPL1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SGPL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/41 Interacting proteins for SGPL1 (O954701, 3 ENSP000003622984) via UniProtKB, MINT, STRING, and/or I2D (see all 41)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TMEM173Q86WV61, 3, ENSP000003312884EBI-1046170,EBI-2800345 I2D: score=1 STRING: ENSP00000331288
    ADSLP305663, ENSP000002161944I2D: score=1 STRING: ENSP00000216194
    SPHK2Q9NRA03, ENSP000002452224I2D: score=1 STRING: ENSP00000245222
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    PIGNO954273, ENSP000003502634I2D: score=1 STRING: ENSP00000350263
    About this table

    Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001553luteinization IEA--
    GO:0001570vasculogenesis IEA--
    GO:0001822kidney development IEA--
    GO:0006644phospholipid metabolic process TAS--
    GO:0006665sphingolipid metabolic process TAS--


    SGPL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SGPL1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SGPL1

    10/38 HMDB Compounds for SGPL1 (see all 38)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cer(d18:0/12:0) ----
    Cer(d18:0/14:0) ----
    Cer(d18:0/16:0) ----
    Cer(d18:0/18:0) ----
    Cer(d18:0/18:1(11Z)) ----
    Cer(d18:0/18:1(9Z)) ----
    Cer(d18:0/20:0) ----
    Cer(d18:0/22:0) ----
    Cer(d18:0/22:1(13Z)) ----
    Cer(d18:0/23:0) ----

    1 DrugBank Compound for SGPL1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetcofactor11377878 15522238

    1 Novoseek chemical compound relationship for SGPL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sphingosine 59.6 1 15258913 (1)

    Search CenterWatch for drugs/clinical trials and news about SGPL1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SGPL1 gene: 
    NM_003901.3  

    Unigene Cluster for SGPL1:

    Sphingosine-1-phosphate lyase 1
    Hs.499984  [show with all ESTs]
    Unigene Representative Sequence: NM_003901
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486993(uc001jrl.2) ENST00000373202(uc001jrm.3 uc009xqk.3)
    ENST00000299297 ENST00000409118

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    hsa-miR-3678-3p hsa-miR-607 hsa-miR-624* hsa-miR-218 hsa-miR-124 hsa-miR-506 hsa-miR-626 hsa-miR-3163
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    Additional cDNA sequence: 

    AB033078.1 AF144638.1 AJ011304.2 AK023873.1 AK308610.1 AK314615.1 BC031338.1 BC041567.1 
    BC051238.1 BC052991.1 BC068061.1 

    12 DOTS entries:

    DT.216906  DT.99934933  DT.100789416  DT.100010662  DT.91748919  DT.121264661  DT.65284746  DT.70103051 
    DT.95308624  DT.95214309  DT.91744923  DT.97776403 

    24/259 AceView cDNA sequences (see all 259):

    BQ778468 AI739573 BU627688 BX371476 BC068061 BF513285 BU608120 AI301617 
    BX282607 AI633968 AA733213 AW574730 BQ679149 AA442998 AI767378 AA338781 
    BM556374 CB214990 AB033078 AW590282 BI253944 AI613091 R84511 NM_003901 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for SGPL1 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^
    SP1:                                -     -     -     -           -     -                                         -                             -           -   
    SP2:                                                              -     -                                         -                                             
    SP3:                          -     -     -     -     -           -     -                                         -                                             
    SP4:                          -     -     -     -     -           -     -                                         -                                             
    SP5:                                -     -     -     -           -     -                                                                                       

    ExUns: 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for SGPL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SGPL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTTATTATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See SGPL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SGPL1

    SOURCE GeneReport for Unigene cluster: Hs.499984

    UniProtKB/Swiss-Prot: SGPL1_HUMAN, O95470
    Tissue specificity: Found in liver and kidney

        SABiosciences Expression via Pathway-Focused PCR Array including SGPL1: 
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for SGPL1 gene from 11/34 species (see all 34)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sgpl11 , 5 sphingosine phosphate lyase 11, 5 84.83(n)1
    84.83(a)1
      10 (32.14 cM)5
    203971  NM_009163.31  NP_033189.21 
     610986425 
    chicken
    (Gallus gallus)
    Aves SGPL11 sphingosine-1-phosphate lyase 1 67.98(n)
    69.11(a)
      423714  NM_001007946.1  NP_001007947.1 
    lizard
    (Anolis carolinensis)
    Reptilia SGPL16
    --
    68(a)
    1 ↔ 1
    3(50345366-50382487)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.101022 Transcribed sequence with moderate similarity to protein more 74.27(n)    BX693739.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sgpl11 sphingosine-1-phosphate lyase 1 65.95(n)
    64.45(a)
      100037312  NM_001089469.1  NP_001082938.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sply1 , 3 sphinganine-1-phosphate aldolase3
    Sphingosine-1-phosphate lyase1
    49(a)3
    55.64(n)1
    50(a)1
      53F83
    460591  NM_166215.11  NP_725652.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y66H1B.43
    tag-381
    Protein TAG-381 43(a)
    (best of 3)3
    49.37(n)1
    39.2(a)1
      IV(380018-383179)3
    1818591  NM_072971.31  NP_505372.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DPL1(YDR294C)4
    DPL11
    Dihydrosphingosine phosphate lyase, regulates intracellular more4
    Dpl1p1
    52.6(n)1
    42.83(a)1
      4(1052228-1050459)4
    8518881, 4  NP_010580.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons DPL11 Sphingosine-1-phosphate lyase 50.55(n)
    44.32(a)
      839691  NM_102563.3  NP_174119.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g01009001 hypothetical protein 48.99(n)
    42.59(a)
      4326459  NM_001048275.2  NP_001041740.2 


    ENSEMBL Gene Tree for SGPL1 (if available)
    TreeFam Gene Tree for SGPL1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1126 NCBI SNPs in SGPL1 are shown (see all 1126    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1999251861,2
    C--66633142(+) TTTATA/GTNNNN 1 -- ut310--------
    rs1501681651,2
    --72573712(+) CACACA/TCACAG 1 -- us2k10--------
    rs1860552781,2
    --72573732(+) GGCTCA/GGAGAG 1 -- us2k10--------
    rs1386293871,2
    --72573808(+) CTGGAC/TCTCAG 1 -- us2k10--------
    rs1157894291,2
    F,--72573872(+) GACCCC/TTCTAG 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs27911801,2
    C,F,H,--72573879(+) CTAGCT/CCTACC 1 -- us2k114Minor allele frequency- C:0.01NA WA CSA EA 379
    rs1164809021,2
    F,--72574110(+) ATGTAA/GAGGTG 1 -- us2k11Minor allele frequency- G:0.06WA 118
    rs1155230001,2
    --72574142(+) GCAAGG/TATCAG 1 -- us2k10--------
    rs27911811,2
    C,H,--72574170(+) GTTTGT/AGCATC 1 -- us2k112Minor allele frequency- A:0.03NA WA CSA 140
    rs1888626951,2
    --72574318(+) GAGGTA/GTGCAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SGPL1 (72575704 - 72640946 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SGPL1
         2 CNVs: 48626 48625

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SGPL1
    DNA2.0 Custom Variant and Variant Library Synthesis for SGPL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SGPL1 for disorders           About GeneDecksing

    OMIM gene information: 603729    OMIM disorders: --

    10 diseases for SGPL1:    About MalaCards
    atopic dermatitis    pituitary adenoma    colon cancer    dermatitis
    adenoma    alzheimer's disease    influenza    lung cancer
    tuberculosis    mycobacterium tuberculosis

    4 Novoseek disease relationships for SGPL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenoma 23.1 1 17361098 (1)
    colon cancer 22.8 2 17361098 (1), 17090686 (1)
    cancer 5.32 6 17416206 (2), 19934311 (1), 19534571 (1), 20215862 (1)
    tumors 0 3 19934311 (1), 17090686 (1)

    Human Genome Epidemiology (HuGE) Navigator: SGPL1 (2 documents)

    Export disorders for SGPL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SGPL1 gene, integrated from 9 sources (see all 51):
    (articles sorted by number of sources associating them with SGPL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer. (PubMed id 17090686)1, 3, 9 Oskouian B....Saba J.D. (2006)
    2. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PubMed id 16777052)1, 2, 9 Zhan X. and Desiderio D.M. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. (PubMed id 14570870)1, 2 Reiss U.... Saba J.D. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22. (PubMed id 11018465)1, 2 Van Veldhoven P.P....Brys V. (2000)
    7. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (1999)
    8. Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast. (PubMed id 9464245)1, 3 Zhou J. and Saba J.D. (1998)
    9. First evidence of sphingosine 1-phosphate lyase protei n expression and activity downregulation in human neoplasm: implication for resi stance to therapeutics in prostate cancer. (PubMed id 22784711)1 Brizuela L....Cuvillier O. (2012)
    10. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8879 HGNC: 10817 AceView: SGPL1 Ensembl:ENSG00000166224 euGenes: HUgn8879
    ECgene: SGPL1 Kegg: 8879 H-InvDB: SGPL1

    (According to HUGE)
    About This Section
    HUGE: KIAA1252

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SGPL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SGPL1 gene:
    Search GeneIP for patents involving SGPL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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