Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SGOL2 Gene

Aliases for SGOL2 Gene

  • Shugoshin-Like 2 (S. Pombe) 2 3
  • TRIPIN 3 4 6
  • SGO2 3 4 6
  • Shugoshin-2 3 4
  • Shugoshin-Like 2 3

External Ids for SGOL2 Gene

Summaries for SGOL2 Gene

GeneCards Summary for SGOL2 Gene

SGOL2 (Shugoshin-Like 2 (S. Pombe)) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for SGOL2 Gene

  • Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.

Gene Wiki entry for SGOL2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGOL2 Gene

Genomics for SGOL2 Gene

Genomic Location for SGOL2 Gene

Start:
200,510,008 bp from pter
End:
200,584,095 bp from pter
Size:
74,088 bases
Orientation:
Plus strand

Genomic View for SGOL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SGOL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGOL2 Gene

Regulatory Elements for SGOL2 Gene

Proteins for SGOL2 Gene

  • Protein details for SGOL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q562F6-SGOL2_HUMAN
    Recommended name:
    Shugoshin-like 2
    Protein Accession:
    Q562F6
    Secondary Accessions:
    • Q53RR9
    • Q53T20
    • Q86XY4
    • Q8IWK2
    • Q8IZK1
    • Q8N1Q5
    • Q96LQ3

    Protein attributes for SGOL2 Gene

    Size:
    1265 amino acids
    Molecular mass:
    144739 Da
    Quaternary structure:
    • Directly interacts with PPP2CA. Part of an astrin (SPAG5) -kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGOL2.
    Miscellaneous:
    • Shugoshin is Japanese for guardian spirit (as it is known to be a protector of centromeric cohesin)
    SequenceCaution:
    • Sequence=AAH35764.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB71617.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC04524.1; Type=Frameshift; Positions=649; Evidence={ECO:0000305};

    Alternative splice isoforms for SGOL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SGOL2 Gene

Proteomics data for SGOL2 Gene at MOPED

Post-translational modifications for SGOL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SGOL2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SGOL2 Gene

Domains for SGOL2 Gene

Protein Domains for SGOL2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SGOL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q562F6

UniProtKB/Swiss-Prot:

SGOL2_HUMAN
Family:
  • Belongs to the shugoshin family.:
    • Q562F6
genes like me logo Genes that share domains with SGOL2: view

No data available for Gene Families for SGOL2 Gene

Function for SGOL2 Gene

Molecular function for SGOL2 Gene

UniProtKB/Swiss-Prot Function: Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.

Gene Ontology (GO) - Molecular Function for SGOL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17485487
genes like me logo Genes that share ontologies with SGOL2: view
genes like me logo Genes that share phenotypes with SGOL2: view

miRNA for SGOL2 Gene

miRTarBase miRNAs that target SGOL2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SGOL2 Gene

Localization for SGOL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SGOL2 Gene

Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=During meiosis I, accumulates at centromeres during diplotene, and colocalizes differentially with the cohesin subunits RAD21 and REC8 at metaphase I centromeres. SGO2 and RAD21 change their relative distributions during telophase I when sister-kinetochore association is lost. During meiosis II, it shows a striking tension-dependent redistribution within centromeres throughout chromosome congression during prometaphase II, as it does during mitosis (By similarity). In Hela cells, localizes at centromeres throughout prophase until metaphase and disappears at anaphase. Centromeric localization requires the presence of BUB1 and AUKRB. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SGOL2 Gene COMPARTMENTS Subcellular localization image for SGOL2 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SGOL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IDA 17485487
GO:0000776 kinetochore --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with SGOL2: view

Pathways for SGOL2 Gene

genes like me logo Genes that share pathways with SGOL2: view

Pathways by source for SGOL2 Gene

Gene Ontology (GO) - Biological Process for SGOL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0051301 cell division IEA --
GO:0051754 meiotic sister chromatid cohesion, centromeric IEA --
genes like me logo Genes that share ontologies with SGOL2: view

Transcripts for SGOL2 Gene

Unigene Clusters for SGOL2 Gene

Shugoshin-like 2 (S. pombe):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SGOL2 Gene

No ASD Table

Relevant External Links for SGOL2 Gene

GeneLoc Exon Structure for
SGOL2
ECgene alternative splicing isoforms for
SGOL2

Expression for SGOL2 Gene

mRNA expression in normal human tissues for SGOL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SGOL2 Gene

This gene is overexpressed in Testis (10.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SGOL2 Gene

SOURCE GeneReport for Unigene cluster for SGOL2 Gene Hs.655182

genes like me logo Genes that share expressions with SGOL2: view

No data available for mRNA Expression by UniProt/SwissProt for SGOL2 Gene

Orthologs for SGOL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SGOL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SGOL2 35
  • 99.42 (n)
  • 98.97 (a)
SGOL2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SGOL2 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SGOL2 35
  • 82.5 (n)
  • 68.54 (a)
SGOL2 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm4975 36
  • 49 (a)
OneToMany
Sgol2 35
  • 75.38 (n)
  • 57.66 (a)
Sgol2 16
Sgol2 36
  • 52 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SGOL2 36
  • 37 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sgol2 35
  • 75 (n)
  • 58.83 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
OneToMany
-- 36
  • 19 (a)
OneToMany
Species with no ortholog for SGOL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SGOL2 Gene

ENSEMBL:
Gene Tree for SGOL2 (if available)
TreeFam:
Gene Tree for SGOL2 (if available)

Paralogs for SGOL2 Gene

No data available for Paralogs for SGOL2 Gene

Variants for SGOL2 Gene

Sequence variations from dbSNP and Humsavar for SGOL2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs700632 -- 200,529,360(-) ccagc(G/T)catgg intron-variant
rs700633 -- 200,529,284(-) ACTAA(A/G)AACTT intron-variant
rs842930 -- 200,528,603(-) actac(G/T)catct intron-variant
rs842931 -- 200,558,664(-) tgacc(A/G)gcata intron-variant
rs842932 -- 200,551,525(-) actta(C/T)atctt intron-variant

Relevant External Links for SGOL2 Gene

HapMap Linkage Disequilibrium report
SGOL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SGOL2 Gene

Disorders for SGOL2 Gene

Relevant External Links for SGOL2

Genetic Association Database (GAD)
SGOL2
Human Genome Epidemiology (HuGE) Navigator
SGOL2
genes like me logo Genes that share disorders with SGOL2: view

No data available for UniProtKB/Swiss-Prot for SGOL2 Gene

Publications for SGOL2 Gene

  1. Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments. (PMID: 17485487) Huang H. … Yen T.J. (J. Cell Biol. 2007) 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PMID: 19898482) Ross C.J. … Hayden M.R. (Nat. Genet. 2009) 3 48
  5. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PMID: 16541025) Kitajima T.S. … Watanabe Y. (Nature 2006) 3 4

Products for SGOL2 Gene

Sources for SGOL2 Gene

Back to Top

Content