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SGOL2 Gene

protein-coding   GIFtS: 53
GCID: GC02P201375

Shugoshin-Like 2 (S. Pombe)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Shugoshin-Like 2 (S. Pombe)1 2     Shugoshin-Like 22
SGO22 5     Sgo23
TRIPIN2 5     Shugoshin-23
shugoshin-22     Tripin3

External Ids:    HGNC: 308121   Entrez Gene: 1512462   Ensembl: ENSG000001635357   OMIM: 6124255   UniProtKB: Q562F63   

Export aliases for SGOL2 gene to outside databases

Previous GC identifers: GC02P201594 GC02P201216 GC02P201099 GC02P193242


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SGOL2 Gene:
SGOL2 (shugoshin-like 2 (S. pombe)) is a protein-coding gene.

UniProtKB/Swiss-Prot: SGOL2_HUMAN, Q562F6
Function: Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes
specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase.
During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing
premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for
an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation
(By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore
attachments

Gene Wiki entry for SGOL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SGOL2 gene promoter:
         LHX3b/Lhx3b   Brachyury   LCR-F1   POU3F2   HNF-3beta   FAC1   POU2F1   POU2F1a   LHX3a/Lhx3a   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSGOL2 promoter sequence
   Search Chromatin IP Primers for SGOL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SGOL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.1   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33.2

SGOL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SGOL2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P201375:  view genomic region     (about GC identifiers)

Start:
201,374,731 bp from pter      End:
201,448,818 bp from pter
Size:
74,088 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SGOL2_HUMAN, Q562F6 (See protein sequence)
Recommended Name: Shugoshin-like 2  
Size: 1265 amino acids; 144739 Da
Subunit: Directly interacts with PPP2CA. Part of an astrin (SPAG5) -kinastrin (SKAP) complex containing KNSTRN,
SPAG5, PLK1, DYNLL1 and SGOL2
Miscellaneous: Shugoshin is Japanese for guardian spirit (as it is known to be a protector of centromeric cohesin)
Sequence caution: Sequence=AAH35764.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAB71617.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAC04524.1; Type=Frameshift; Positions=649;
Secondary accessions: Q53RR9 Q53T20 Q86XY4 Q8IWK2 Q8IZK1 Q8N1Q5 Q96LQ3
Alternative splicing: 3 isoforms:  Q562F6-1   Q562F6-2   Q562F6-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SGOL2: NX_Q562F6

Explore proteomics data for SGOL2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SGOL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001153505.1  NP_001153518.1  NP_689737.4  

    ENSEMBL proteins: 
     ENSP00000393325   ENSP00000350447   ENSP00000386249  
    Reactome Protein details: Q562F6

    SGOL2 Human Recombinant Protein Products:

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    LSBio Antibodies in human, mouse, rat for SGOL2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026706 SGOL2

    Graphical View of Domain Structure for InterPro Entry Q562F6

    ProtoNet protein and cluster: Q562F6

    UniProtKB/Swiss-Prot: SGOL2_HUMAN, Q562F6
    Similarity: Belongs to the shugoshin family


    Find genes that share domains with SGOL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SGOL2_HUMAN, Q562F6
    Function: Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes
    specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase.
    During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing
    premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for
    an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation
    (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore
    attachments

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17485487
         
    Find genes that share ontologies with SGOL2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SGOL2:
     Upregulation of Wnt/beta-caten 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sgol2):
     behavior/neurological  cellular  endocrine/exocrine gland  homeostasis/metabolism  reproductive system 

    Find genes that share phenotypes with SGOL2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SGOL2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SGOL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SGOL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SGOL2

    miRNA
    Products:
        
    miRTarBase miRNAs that target SGOL2:
    hsa-mir-192-5p (MIRT026157), hsa-mir-215-5p (MIRT024332), hsa-mir-375 (MIRT019725)

    Block miRNA regulation of human, mouse, rat SGOL2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate SGOL2:
    hsa-miR-2052 hsa-miR-491-3p
    SwitchGear 3'UTR luciferase reporter plasmidSGOL2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat SGOL2

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): SGOL2 (NM_001160046)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGOL2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGOL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SGOL2_HUMAN, Q562F6: Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore (By similarity).
    Note=During meiosis I, accumulates at centromeres during diplotene, and colocalizes differentially with the
    cohesin subunits RAD21 and REC8 at metaphase I centromeres. SGO2 and RAD21 change their relative distributions
    during telophase I when sister-kinetochore association is lost. During meiosis II, it shows a striking
    tension-dependent redistribution within centromeres throughout chromosome congression during prometaphase II, as
    it does during mitosis (By similarity). In Hela cells, localizes at centromeres throughout prophase until
    metaphase and disappears at anaphase. Centromeric localization requires the presence of BUB1 and AUKRB
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IDA17485487
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with SGOL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SGOL2 About    
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92


    Find genes that share SuperPaths with SGOL2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Reactome Pathways for SGOL2
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SGOL2
    Interactions:

        Search GeneGlobe Interaction Network for SGOL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SGOL2 (Q562F61, 2, 3 ENSP000003504474) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAD2L1Q132571, 2, 3EBI-989213,EBI-78203 MINT-8212643 MINT-8295741 MINT-8210333 MINT-8211871 MINT-8210370 MINT-8210344 MINT-8210355 MINT-8211862 MINT-8210383 MINT-8212589 MINT-8211761 I2D: score=2 
    PPP1CAP621361, 2, 3EBI-989213,EBI-357253 MINT-8212643 MINT-8212619 MINT-8212589 MINT-8210383 I2D: score=1 
    MAD2L1BPQ150131, 2, 3EBI-989213,EBI-712181 MINT-8211808 MINT-8211761 I2D: score=1 
    PPP2R5DQ147382, 3, ENSP000004179634MINT-8212557 I2D: score=2 STRING: ENSP00000417963
    PPP2R1BP301543, ENSP000003113444I2D: score=2 STRING: ENSP00000311344
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007059chromosome segregation IEA--
    GO:0007126meiotic nuclear division IEA--
    GO:0051301cell division ----
    GO:0051754meiotic sister chromatid cohesion, centromeric ----

    Find genes that share ontologies with SGOL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SGOL2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SGOL2 gene (3 alternative transcripts): 
    NM_001160033.1  NM_001160046.1  NM_152524.5  

    Unigene Cluster for SGOL2:

    Shugoshin-like 2 (S. pombe)
    Hs.655182  [show with all ESTs]
    Unigene Representative Sequence: NM_152524
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418045 ENST00000357799(uc010zhd.1 uc002uvw.2 uc010zhe.1)
    ENST00000409203(uc002uvv.4) ENST00000460534 ENST00000488636 ENST00000469840

    miRNA
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    Block miRNA regulation of human, mouse, rat SGOL2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate SGOL2:
    hsa-miR-2052 hsa-miR-491-3p
    SwitchGear 3'UTR luciferase reporter plasmidSGOL2 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SGOL2 (NM_001160046)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SGOL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGOL2
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat SGOL2
      QuantiFast Probe-based Assays in human, mouse, rat SGOL2

    Additional mRNA sequence: 

    AK057940.1 AK095291.1 AK302457.1 AY094614.1 BC004567.2 BC035764.1 BC048349.1 BC092412.1 
    BC110583.2 BX647433.1 

    6 DOTS entries:

    DT.310968  DT.100745205  DT.120971938  DT.100024087  DT.100745206  DT.120971959 

    Selected AceView cDNA sequences (see all 88):

    BX643025 N42444 AK095291 BC004567 AW592556 AA284372 AA811814 AA292611 
    BC048349 AI651208 BM806118 AA280255 AA804785 AA897307 AA732496 BQ082148 
    BX117626 BX109357 AA465090 AI357263 BQ029778 BI856051 BP432474 AL045632 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SGOL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTGTTGAT
    SGOL2 Expression
    About this image


    SGOL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Thalamus
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Ovary (Reproductive System)
             XX Germ Cells Ovigerous Cord
     
     Gonad
             XX Germ Cells Ovigerous Cord
    SGOL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SGOL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655182
        Custom PCR Arrays for SGOL2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SGOL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SGOL2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGOL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SGOL2 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sgol21 , 5 shugoshin-like 2 (S. pombe)1, 5 75.38(n)1
    57.66(a)1
      1 (28.86 cM)5
    685491  NM_199007.21  NP_950172.11 
     579959715 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    55(a)
    19(a)
    many → 1
    many → 1
    1(117833110-117837335)
    4(90516021-90530295)


    ENSEMBL Gene Tree for SGOL2 (if available)
    TreeFam Gene Tree for SGOL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SGOL2 (see all 1113)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs116817411,2
    C,F,H--201389078(+) ACTTTT/CAGGTT 3 -- us2k1 tfbs314Minor allele frequency- C:0.15NS EA NA WA 902
    rs75690991,2
    C,F,A--201389426(+) ACCTCA/GTGATC 3 -- us2k13Minor allele frequency- G:0.33NA WA 6
    rs730441201,2
    C--201389646(+) TAATGT/CATTTG 3 -- us2k12Minor allele frequency- C:0.10WA 120
    rs1829735231,2
    --201389813(+) AAAAAC/GATATA 3 -- us2k10--------
    rs1410359771,2
    --201389908(+) CCAGTA/GTATTA 3 -- us2k10--------
    rs168336641,2
    C,F--201389987(+) AGATTC/TATGTA 3 -- us2k113Minor allele frequency- T:0.10NA EA WA CSA 1458
    rs794615931,2
    F--201390382(+) TTGTAT/CATTCA 3 -- us2k11Minor allele frequency- C:0.01NA 120
    rs101964391,2
    C,F,H--201390401(+) AGACCA/GTTAGT 3 -- us2k110Minor allele frequency- G:0.02NS EA NA WA 1210
    rs1145333071,2
    F--201390646(+) TGTGAT/CTGATA 3 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1887382341,2
    C--201390702(+) ACAGCA/GGACCG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for SGOL2 (201374731 - 201448818 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SGOL2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SGOL2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612425    OMIM disorders: --


    Find genes that share disorders with SGOL2           About GenesLikeMe

    Genetic Association Database (GAD): SGOL2
    Human Genome Epidemiology (HuGE) Navigator: SGOL2 (1 document)

    Export disorders for SGOL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SGOL2 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with SGOL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments. (PubMed id 17485487)1, 2, 9 Huang H.... Yen T.J. (J. Cell Biol. 2007)
    2. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PubMed id 19898482)1, 4 Ross C.J....Hayden M.R. (Nat. Genet. 2009)
    3. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PubMed id 16541025)1, 2 Kitajima T.S.... Watanabe Y. (Nature 2006)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    8. The astrin-kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment. (PubMed id 21402792)2 Dunsch A.K.... Gruneberg U. (J. Cell Biol. 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres. (PubMed id 20889715)1 Tanno Y....Watanabe Y. (amp 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 151246 HGNC: 30812 AceView: SGOL2 Ensembl:ENSG00000163535 euGenes: HUgn151246
    ECgene: SGOL2 H-InvDB: SGOL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SGOL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SGOL2 gene:
    Search GeneIP for patents involving SGOL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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