SGOL1 Gene
protein-coding GIFtS: 54
GCID: GC03M020179
|
|
shugoshin-like 1 (S. pombe)
| |
Aliases
for SGOL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Shugoshin-Like 1 (S. Pombe)1 2 | | Shugoshin 1AB Protein2 | | NY-BR-851 2 | | Shugoshin 1CD Protein2 | | Serologically Defined Breast Cancer Antigen NY-BR-852 3 | | Shugoshin 1EF Protein2 | | HSgo11 | | Shugoshin 1GH Protein2 | | SGO2 5 | | Shugoshin 1KL Protein2 | | SGO13 5 | | Shugoshin-Like 12 | | Sgo12 | | |
Export aliases for SGOL1 gene to outside databasesPrevious GC identifer: GC03M020178 |
Summaries
for SGOL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SGOL1_HUMAN, Q5FBB7Function: Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesincomplex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act bypreventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence atcentromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation duringmitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosomecongression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochorelocalization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint byregulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controllingspindle pole integrity
Gene Wiki entry for SGOL1
|
Genomic Views
for SGOL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SGOL1 gene promoter:
N-Myc NF-AT4 NF-AT2 NF-AT3 NF-AT NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SGOL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SGOL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p24.3 Ensembl cytogenetic band: 3p24.3 HGNC cytogenetic band: 3p24.3SGOL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M020179: view genomic region
(about GC identifiers)
Start:
|
20,202,085 bp from pter |
End:
|
20,227,784 bp from pter |
Size:
|
25,700 bases |
Orientation:
|
minus strand |
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Proteins
for SGOL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SGOL1_HUMAN, Q5FBB7 (See
protein sequence)Recommended Name: Shugoshin-like 1 Size: 561 amino acids; 64190 Da
Subunit: Interacts with PPP2CA (or PPP2CB), PPP2R1B, PPP2R5A, PPP2R5B, PPP2R5C, PPP2R5D, PPP2R5E, SET, LRRC59, RBM10(or RBM5), RPL10A, RPL28, RPL7, RPL7A and RPLP1. Interaction with protein phosphatase 2A occurs most probably throughdirect binding to the regulatory B56 subunits: PPP2R1B, PPP2R5A, PPP2R5B, PPP2R5C, PPP2R5D, PPP2R5E. Interacts withPPP2R1A and NEK2. Isoform 3 interacts with PLK1
Subcellular location: Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton,spindle pole. Cytoplasm, cytoskeleton, centrosome. Note=Localizes to the inner centromere throughout prophase untilmetaphase and disappears at anaphase. During prometaphase, it localizes to a single focus, while at metaphase, itlocalizes to 2 spots corresponding to the 2 centromeres. Centromeric localization requires the presence of BUB1 andthe interaction with PPP2R1A. Localizes to the inner kinetochore from prophase to early metaphase. Co-localizes withNEK2 and SS18L1 at the kinetochore. Phosphorylation by AUKRB and the presence of BUB1 are required for localization tothe kinetochore. Isoform 1 primarily localizes to kinetochores during G2 phase and mitotic prophase, metaphase, andanaphase and does not appear to be associated with kinetochores during late mitosis. Isoform 3 is found at thecentrosome in interphase and at spindle poles in mitosis and its spindle pole localization is PLK1 dependent. Isoform3 does not localize to kinetochores during any stages of the cell cycle
Developmental stage: Appears in prophase cells and remains present until metaphase. Strongly decreases at the onset ofanaphase and completely disappears at telophase. Not present in interphase cells (at protein level)
Miscellaneous: Shugoshin is Japanese for guardian spirit (as it is known to be a protector of centromeric cohesin)
Sequence caution: Sequence=AAH01339.2; Type=Erroneous initiation; Sequence=AAH32696.1; Type=Erroneous initiation;
3 PDB 3D structures from  and Proteopedia  for SGOL1:3FGA (3D)
3Q6S (3D)
4A0I (3D)
Secondary accessions: Q588H5 Q5FBB4 Q5FBB5 Q5FBB6 Q5FBB8 Q8N579 Q8WVL0 Q9BVA8 Q9H275Alternative splicing: 7 isoforms: Q5FBB7-1 Q5FBB7-2 Q5FBB7-3 Q5FBB7-4 Q5FBB7-5 Q5FBB7-6 Q5FBB7-7 Explore the universe of human proteins at neXtProt for SGOL1: NX_Q5FBB7
Post-translational modifications:
Ubiquitinated and degraded during mitotic exit by APC/C-Cdh11
Phosphorylation by NEK2 is essential for chromosome congression in mitosis and for the proper attachment of spindlemicrotubule to the kinetochore. Phosphorylated by PLK1 and AUKRB1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5FBB7
SGOL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (13 alternative transcripts):
NP_001012409.1 NP_001012410.1 NP_001012411.1 NP_001012412.1 NP_001012413.1 NP_001186180.1 NP_001186181.1 NP_001186182.1 NP_001186183.1 NP_001186184.1 NP_001186185.1 NP_001186186.1 NP_612493.1
ENSEMBL proteins: ENSP00000306581 ENSP00000394625 ENSP00000263753 ENSP00000414960 ENSP00000413070 ENSP00000414129 ENSP00000411200 ENSP00000394957 ENSP00000410458 ENSP00000389034 ENSP00000394613 ENSP00000397672 ENSP00000373284 ENSP00000406880 ENSP00000404562 Reactome Protein details: Q5FBB7
Human Recombinant Protein Products:
Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table
SGOL1 for ontologies About GeneDecksing
SGOL1 Antibody Products:
Assay Products for SGOL1: |
Protein
Domains /
Families
for SGOL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SGOL1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5FBB7ProtoNet protein and cluster: Q5FBB7 UniProtKB/Swiss-Prot: SGOL1_HUMAN, Q5FBB7Domain: The KEN box and D-box 3 are required for its ubiquitination and degradationSimilarity: Belongs to the shugoshin family |
Function
for SGOL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SGOL1_HUMAN, Q5FBB7Function: Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesincomplex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act bypreventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence atcentromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation duringmitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosomecongression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochorelocalization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint byregulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controllingspindle pole integrity
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SGOL1 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SGOL1 (see all 6)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 13): SGOL1 (NM_001199252) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SGOL1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGOL1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGOL1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
SGOL1 for ontologies About GeneDecksing
7 GenomeRNAi human phenotypes for SGOL1:
Animal Models:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Sgol1):
SGOL1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SGOL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | M Phase | | | 2 | Resolution of Sister Chromatid Cohesion | | | 3 | Cell Cycle | | | 4 | Aurora B signaling | | | 5 | PLK1 signaling events | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for SGOL1
5/10 
Reactome Pathways for SGOL1 (see all 10)
1 
Kegg Pathway (Kegg details for SGOL1):
SGOL1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SGOL1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/104 Interacting proteins for SGOL1 (Q5FBB71, 2, 3 ENSP000002637534) via UniProtKB, MINT, STRING, and/or I2D (see all 104)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
SGOL1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SGOL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SGOL1
Search CenterWatch for drugs/clinical trials and news about SGOL1
|
Transcripts
for SGOL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SGOL1 gene (13 alternative transcripts): NM_001012409.2 NM_001012410.3 NM_001012411.2 NM_001012412.3 NM_001012413.2 NM_001199251.1 NM_001199252.1 NM_001199253.1 NM_001199254.1 NM_001199255.1 NM_001199256.1 NM_001199257.1 NM_138484.3 Unigene Cluster for SGOL1: Shugoshin-like 1 (S. pombe) Hs.105153 [show with all ESTs]Unigene Representative Sequence: NM_00119925116 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000306698(uc003cbw.3 uc003cbr.3) ENST00000419233(uc003cbv.3 uc003cbt.3 uc010hfa.3)
ENST00000263753(uc003cbu.3 uc003cbs.3) ENST00000425061 ENST00000443724
ENST00000421451 ENST00000452020 ENST00000442720(uc003ccc.3 uc021wtx.1 uc021wty.1 uc003ccb.3 uc003cby.3 uc003cbx.3)
ENST00000412997(uc003cca.3 uc003cbz.3) ENST00000460637 ENST00000437051
ENST00000417364 ENST00000456624 ENST00000383774 ENST00000412868 ENST00000429446
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SGOL1 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SGOL1 (see all 6)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 13): SGOL1 (NM_001199252) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SGOL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGOL1 |
Additional cDNA sequence: AB187577.1 AB187578.1 AB187579.1 AB187580.1 AB187581.1 AB187582.1 AB190994.1 AB193056.1 AB193057.1 AB193058.1 AB193059.1 AB193060.1 AB193061.1 AB193062.1 AB193063.1 AB193064.1 AB193065.1 AB193066.1 AB451340.1 AB451489.1 AB567656.1 AB567657.1 AF308299.1 AK024292.1 AK308095.1 BC001339.2 BC017867.1 BC032696.1 BC039605.1 BX648516.1 NR_046723.1 11 DOTS entries: DT.203313 DT.95118430 DT.95237273 DT.100659431 DT.100728697 DT.120900907 DT.120900903 DT.100020470 DT.91727397 DT.433101 DT.99995913 24/54 AceView cDNA sequences (see all 54): BF983603 AA514803 AF308299 BM463207 BP353118 AA481066 AA631163 NM_138484 BU195471 BC017867 BM457156 BM147491 AK024292 AI051509 BG394433 BM148884 BC032696 AI248925 BF035618 BM014461 AA481123 BU164324 AI983275 BX350945
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SGOL1 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10 |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for SGOL1
|
Expression
for SGOL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SGOL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATTCACTAA
About this image
See SGOL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SGOL1
SOURCE GeneReport for Unigene cluster: Hs.105153
UniProtKB/Swiss-Prot: SGOL1_HUMAN, Q5FBB7Tissue specificity: Widely expressed. Highly expressed in testis. Expressed in lung, small intestine, breast, liver andplacenta. Strongly overexpressed in 90% of breast cancers tested
SABiosciences Custom PCR Arrays for SGOL1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SGOL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SGOL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SGOL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SGOL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGOL1 |
Orthologs
for SGOL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SGOL1 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for SGOL1 (if available)
TreeFam Gene Tree for SGOL1 (if available) |
Paralogs
for SGOL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SGOL1 gene
SGOL1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for SGOL1
PGOHUM00000244068 PGOHUM00000232695
|
Genomic Variants
for SGOL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SGOL1 (20202085 - 20227784 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for SGOL1
4 CNVs: 63413 37531 5371 8415 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SGOL1 |
|
Disorders
/ Diseases
for SGOL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SGOL1 for disorders About GeneDecksing
OMIM gene information: 609168
OMIM disorders: --
8  diseases for SGOL1: About MalaCardsbreast cancer roberts syndrome fanconi's anemia myocarditis
gout endometrial cancer anemia colorectal cancer
1 disease from the University of Copenhagen DISEASES database for SGOL1:Chagas disease Human Genome Epidemiology (HuGE) Navigator: SGOL1 (1 document)
Export disorders for SGOL1 gene to outside databases
|
Publications
for SGOL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SGOL1 gene, integrated from 9 sources (see all 54):
(articles sorted by number of sources associating them with SGOL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (PubMed id 12747765)1, 2, 3 Scanlan M.J.... Old L.J. (2001)
- Differential subcellular localizations of two human Sgo1 isoforms: implications in regulation of sister chromatid cohesion and microtubule dynamics. (PubMed id 16582621)1, 2, 9 Wang X.... Dai W. (2006)
- Multiple anaphase-promoting complex/cyclosome degrons mediate the degradation of human Sgo1. (PubMed id 19015261)1, 2, 9 Karamysheva Z.... Yu H. (2009)
- PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. (PubMed id 16580887)1, 2, 9 Tang Z....Yu H. (2006)
- Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis. (PubMed id 15604152)1, 2, 9 Tang Z.... Yu H. (2004)
- sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1. (PubMed id 18331714)1, 2 Wang X....Dai W. (2008)
- Phosphorylation of human Sgo1 by NEK2A is essential for chromosome congression in mitosis. (PubMed id 17621308)1, 2 Fu G....Yao X. (2007)
- Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1. (PubMed id 17617734)1, 2 Pouwels J.... Kallio M.J. (2007)
- Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PubMed id 16541025)1, 2 Kitajima T.S.... Watanabe Y. (2006)
- Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells. (PubMed id 15737064)1, 2 McGuinness B.E.... Nasmyth K. (2005)
|
External Searches for SGOL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SGOL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SGOL1 gene
(According to HUGE)
About This Section
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Specialized Databases showing SGOL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for SGOL1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for SGOL1 gene:
Search GeneIP for patents involving SGOL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SGOL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for SGOL1 | | OriGene shRNA RFP for SGOL1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SGOL1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SGOL1 | | | OriGene Protein Over-expression Lysate for SGOL1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SGOL1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SGOL1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SGOL1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SGOL1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SGOL1 | | OriGene Custom Protein Services for SGOL1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SGOL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SGOL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SGOL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SGOL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SGOL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SGOL1 |
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| | | | Search Tocris compounds for SGOL1 |
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 | | | SGOL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGOL1 |
|  |  |  | | | | Search ThermoFisher Antibodies for SGOL1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGOL1 |
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