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SGOL1 Gene

protein-coding   GIFtS: 60
GCID: GC03M020179

Shugoshin-Like 1 (S. Pombe)

  See SGOL1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Shugoshin-Like 1 (S. Pombe)1 2     Shugoshin 1AB Protein2
Serologically Defined Breast Cancer Antigen NY-BR-852 3     Shugoshin 1CD Protein2
hSgo12 3     Shugoshin 1EF Protein2
SGO2 5     Shugoshin 1GH Protein2
SGO13 5     Shugoshin 1KL Protein2
NY-BR-852     Shugoshin-Like 12
Sgo12     

External Ids:    HGNC: 250881   Entrez Gene: 1516482   Ensembl: ENSG000001298107   OMIM: 6091685   UniProtKB: Q5FBB73   

Export aliases for SGOL1 gene to outside databases

Previous GC identifer: GC03M020178


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SGOL1 Gene:
SGOL1 (shugoshin-like 1 (S. pombe)) is a protein-coding gene. Diseases associated with SGOL1 include breast cancer.

UniProtKB/Swiss-Prot: SGOL1_HUMAN, Q5FBB7
Function: Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of
cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms.
May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin
persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome
segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is
necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore.
Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the
spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining
centriole cohesion involved in controlling spindle pole integrity

Gene Wiki entry for SGOL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SGOL1 gene promoter:
         N-Myc   NF-AT4   NF-AT2   NF-AT3   NF-AT   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSGOL1 promoter sequence
   Search Chromatin IP Primers for SGOL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SGOL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.3   Ensembl cytogenetic band:  3p24.3   HGNC cytogenetic band: 3p24.3

SGOL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SGOL1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M020179:  view genomic region     (about GC identifiers)

Start:
20,202,085 bp from pter      End:
20,227,784 bp from pter
Size:
25,700 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SGOL1_HUMAN, Q5FBB7 (See protein sequence)
Recommended Name: Shugoshin-like 1  
Size: 561 amino acids; 64190 Da
Subunit: Interacts with PPP2CA (or PPP2CB), PPP2R1B, PPP2R5A, PPP2R5B, PPP2R5C, PPP2R5D, PPP2R5E, SET, LRRC59,
RBM10 (or RBM5), RPL10A, RPL28, RPL7, RPL7A and RPLP1. Interaction with protein phosphatase 2A occurs most
probably through direct binding to the regulatory B56 subunits: PPP2R1B, PPP2R5A, PPP2R5B, PPP2R5C, PPP2R5D,
PPP2R5E. Interacts with PPP2R1A and NEK2. Isoform 3 interacts with PLK1
Developmental stage: Appears in prophase cells and remains present until metaphase. Strongly decreases at the
onset of anaphase and completely disappears at telophase. Not present in interphase cells (at protein level)
Miscellaneous: Shugoshin is Japanese for guardian spirit (as it is known to be a protector of centromeric cohesin)
Sequence caution: Sequence=AAH01339.2; Type=Erroneous initiation; Sequence=AAH32696.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for SGOL1:
3FGA (3D)        3Q6S (3D)        4A0I (3D)    
Secondary accessions: Q588H5 Q5FBB4 Q5FBB5 Q5FBB6 Q5FBB8 Q8N579 Q8WVL0 Q9BVA8 Q9H275
Alternative splicing: 7 isoforms:  Q5FBB7-1   Q5FBB7-2   Q5FBB7-3   Q5FBB7-4   Q5FBB7-5   Q5FBB7-6   Q5FBB7-7   

Explore the universe of human proteins at neXtProt for SGOL1: NX_Q5FBB7

Explore proteomics data for SGOL1 at MOPED

Post-translational modifications: 

  • Ubiquitinated and degraded during mitotic exit by APC/C-Cdh11
  • Phosphorylation by NEK2 is essential for chromosome congression in mitosis and for the proper attachment of
    spindle microtubule to the kinetochore. Phosphorylated by PLK1 and AUKRB1
  • Ubiquitination2 at Lys454
  • Modification sites at PhosphoSitePlus

  • See SGOL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (13 alternative transcripts): 
    NP_001012409.1  NP_001012410.1  NP_001012411.1  NP_001012412.1  NP_001012413.1  NP_001186180.1  NP_001186181.1  NP_001186182.1  
    NP_001186183.1  NP_001186184.1  NP_001186185.1  NP_001186186.1  NP_612493.1  

    ENSEMBL proteins: 
     ENSP00000306581   ENSP00000394625   ENSP00000263753   ENSP00000414960   ENSP00000413070  
     ENSP00000414129   ENSP00000411200   ENSP00000394957   ENSP00000410458   ENSP00000389034  
     ENSP00000394613   ENSP00000397672   ENSP00000373284   ENSP00000406880   ENSP00000404562  
    Reactome Protein details: Q5FBB7

    SGOL1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for SGOL1
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    OriGene Custom Protein Services for SGOL1
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    Novus Biologicals SGOL1 Protein
    Novus Biologicals SGOL1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SGOL1

     
    Search eBioscience for Proteins for SGOL1 

    SGOL1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SGOL1
    Browse R&D Systems for Antibodies
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    Novus Biologicals SGOL1 Antibodies
    Abcam antibodies for SGOL1
    Cloud-Clone Corp. Antibodies for SGOL1
    ThermoFisher Antibodies for SGOL1
    LSBio Antibodies in human, mouse, rat for SGOL1

    SGOL1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SGOL1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SGOL1
    Cloud-Clone Corp. CLIAs for SGOL1
    Search eBioscience for ELISAs for SGOL1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011516 Shugoshin_N
     IPR011515 Shugoshin_C

    Graphical View of Domain Structure for InterPro Entry Q5FBB7

    ProtoNet protein and cluster: Q5FBB7

    UniProtKB/Swiss-Prot: SGOL1_HUMAN, Q5FBB7
    Domain: The KEN box and D-box 3 are required for its ubiquitination and degradation
    Similarity: Belongs to the shugoshin family


    Find genes that share domains with SGOL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SGOL1_HUMAN, Q5FBB7
    Function: Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of
    cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms.
    May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin
    persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome
    segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is
    necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore.
    Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the
    spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining
    centriole cohesion involved in controlling spindle pole integrity

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16541025
         
    Find genes that share ontologies with SGOL1           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for SGOL1:
     Abundance of large cells with   Cell cycle / mitosis defect  Decreased Hepatitis C virus re  Increased G2M DNA content, inc 
     Increased gamma-H2AX phosphory  Increased number of cells in m  Increased number of mitotic ce 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sgol1):
     cellular  digestive/alimentary  endocrine/exocrine gland  hematopoietic system  immune system 
     mortality/aging  tumorigenesis 

    Find genes that share phenotypes with SGOL1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SGOL1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SGOL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SGOL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SGOL1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SGOL1:
    hsa-mir-193b-3p (MIRT016264)

    Block miRNA regulation of human, mouse, rat SGOL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SGOL1 (see all 10):
    hsa-miR-4311 hsa-miR-600 hsa-miR-137 hsa-miR-3065-5p hsa-miR-583 hsa-miR-1276 hsa-miR-377 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidSGOL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SGOL1
    Predesigned siRNA for gene silencing in human, mouse, rat SGOL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SGOL1

    Clone
    Products:
         
    OriGene clones in human, mouse for SGOL1 (see all 29)
    OriGene ORF clones in mouse, rat for SGOL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 13): SGOL1 (NM_001199252)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SGOL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGOL1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SGOL1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGOL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SGOL1_HUMAN, Q5FBB7: Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Cytoplasm,
    cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to
    the inner centromere throughout prophase until metaphase and disappears at anaphase. During prometaphase, it
    localizes to a single focus, while at metaphase, it localizes to 2 spots corresponding to the 2 centromeres.
    Centromeric localization requires the presence of BUB1 and the interaction with PPP2R1A. Localizes to the inner
    kinetochore from prophase to early metaphase. Colocalizes with NEK2 and SS18L1 at the kinetochore.
    Phosphorylation by AUKRB and the presence of BUB1 are required for localization to the kinetochore. Isoform 1
    primarily localizes to kinetochores during G2 phase and mitotic prophase, metaphase, and anaphase and does not
    appear to be associated with kinetochores during late mitosis. Isoform 3 is found at the centrosome in interphase
    and at spindle poles in mitosis and its spindle pole localization is PLK1 dependent. Isoform 3 does not localize
    to kinetochores during any stages of the cell cycle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IDA16682347
    GO:0000776colocalizes with kinetochore IDA16582621
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0000779condensed chromosome, centromeric region IDA19465021
    GO:0000780condensed nuclear chromosome, centromeric region IEA--

    Find genes that share ontologies with SGOL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SGOL1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92
    4Oocyte meiosis
    Oocyte meiosis0.35
    5PLK1 signaling events
    PLK1 signaling events


    Find genes that share SuperPaths with SGOL1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for SGOL1
        PLK1 signaling events
    Aurora B signaling

    3 Reactome Pathways for SGOL1
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids


    1 Kegg Pathway  (Kegg details for SGOL1):
        Oocyte meiosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SGOL1
    Interactions:

        GeneGlobe Interaction Network for SGOL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SGOL1 (Q5FBB71, 2, 3 ENSP000002637534) via UniProtKB, MINT, STRING, and/or I2D (see all 104)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2R5AQ151721, 3, ENSP000002614614EBI-989069,EBI-641666 I2D: score=2 STRING: ENSP00000261461
    PPP2R5DQ147382, 3, ENSP000004179634MINT-8295766 I2D: score=3 STRING: ENSP00000417963
    PPP2R1AP301533, ENSP000003248044I2D: score=2 STRING: ENSP00000324804
    AURKBQ96GD43, ENSP000003139504I2D: score=1 STRING: ENSP00000313950
    CDCA8Q53HL23, ENSP000003161214I2D: score=1 STRING: ENSP00000316121
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007059chromosome segregation IDA16580887
    GO:0007067mitosis IEA--
    GO:0008608attachment of spindle microtubules to kinetochore IDA17621308
    GO:0010457centriole-centriole cohesion IDA18331714

    Find genes that share ontologies with SGOL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SGOL1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SGOL1 gene (13 alternative transcripts): 
    NM_001012409.2  NM_001012410.3  NM_001012411.2  NM_001012412.3  NM_001012413.2  NM_001199251.1  NM_001199252.1  NM_001199253.1  
    NM_001199254.1  NM_001199255.1  NM_001199256.1  NM_001199257.1  NM_138484.3  

    Unigene Cluster for SGOL1:

    Shugoshin-like 1 (S. pombe)
    Hs.105153  [show with all ESTs]
    Unigene Representative Sequence: NM_001199251
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306698(uc003cbw.3 uc003cbr.3) ENST00000419233(uc003cbv.3 uc003cbt.3 uc010hfa.3)
    ENST00000263753(uc003cbu.3 uc003cbs.3) ENST00000425061 ENST00000443724
    ENST00000421451 ENST00000452020 ENST00000442720(uc003ccc.3 uc021wtx.1 uc021wty.1 uc003ccb.3 uc003cby.3 uc003cbx.3)
    ENST00000412997(uc003cca.3 uc003cbz.3) ENST00000460637 ENST00000437051
    ENST00000417364 ENST00000456624 ENST00000383774 ENST00000412868 ENST00000429446

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SGOL1 (see all 10):
    hsa-miR-4311 hsa-miR-600 hsa-miR-137 hsa-miR-3065-5p hsa-miR-583 hsa-miR-1276 hsa-miR-377 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidSGOL1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SGOL1
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 13): SGOL1 (NM_001199252)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGOL1
    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat SGOL1

    Additional mRNA sequence: 

    AB187577.1 AB187578.1 AB187579.1 AB187580.1 AB187581.1 AB187582.1 AB190994.1 AB193056.1 
    AB193057.1 AB193058.1 AB193059.1 AB193060.1 AB193061.1 AB193062.1 AB193063.1 AB193064.1 
    AB193065.1 AB193066.1 AB451340.1 AB451489.1 AB567656.1 AB567657.1 AF308299.1 AK024292.1 
    AK308095.1 BC001339.2 BC017867.1 BC032696.1 BC039605.1 BX648516.1 NR_046723.1 

    11 DOTS entries:

    DT.203313  DT.95118430  DT.95237273  DT.100659431  DT.100728697  DT.120900907  DT.120900903  DT.100020470 
    DT.91727397  DT.433101  DT.99995913 

    Selected AceView cDNA sequences (see all 54):

    AF308299 AA514803 AA481066 BM463207 BU195471 BP353118 BC017867 NM_138484 
    BF983603 AA631163 AI983275 BI089107 BX494477 BC001339 AA481123 BU164324 
    AI051509 BX648516 BX350945 BG394433 BC039605 BM457156 BG394361 BM014461 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SGOL1 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10
    SP1:                    -     -                                                     -     -     -     -                                 
    SP2:                                                                                -     -     -     -                                 
    SP3:                    -     -                                               -     -     -     -     -                                 
    SP4:                                                                                -     -     -     -     -     -     -     -         
    SP5:                                                                          -     -     -     -     -                                 


    ECgene alternative splicing isoforms for SGOL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SGOL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTCACTAA
    SGOL1 Expression
    About this image


    SGOL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
             Cerebral Cortex
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    SGOL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SGOL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.105153

    UniProtKB/Swiss-Prot: SGOL1_HUMAN, Q5FBB7
    Tissue specificity: Widely expressed. Highly expressed in testis. Expressed in lung, small intestine, breast,
    liver and placenta. Strongly overexpressed in 90% of breast cancers tested

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SGOL1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sgol11 , 5 shugoshin-like 1 (S. pombe)1, 5 71.96(n)1
    55.04(a)1
      17 (27.92 cM)5
    724151  NM_028232.21  NP_082508.11 
     536747865 
    chicken
    (Gallus gallus)
    Aves SGOL11 shugoshin-like 1 (S. pombe) 50.51(n)
    39.6(a)
      420650  NM_001199648.1  NP_001186577.1 
    lizard
    (Anolis carolinensis)
    Reptilia SGOL16
    shugoshin-like 1 (S. pombe)
    33(a)
    1 ↔ 1
    6(32849361-32865768)
    zebrafish
    (Danio rerio)
    Actinopterygii SGOL16
    shugoshin-like 1 (S. pombe)
    22(a)
    1 ↔ 1
    19(49965025-49976798) ENSDARG00000069916


    ENSEMBL Gene Tree for SGOL1 (if available)
    TreeFam Gene Tree for SGOL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SGOL1 gene

    Find genes that share paralogs with SGOL1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for SGOL1
    PGOHUM00000244068 PGOHUM00000232695


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SGOL1 (see all 281)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1839824571,2
    --20141498(+) GGTTGA/GAAAGA 7 -- int10--------
    rs1900065341,2
    --20141573(+) AACAAA/TGGCCC 7 -- int10--------
    rs1816788151,2
    --20201695(+) AAATAA/CAAATC 7 -- int10--------
    rs1870966951,2
    --20201782(+) ATTAAA/GAAAAT 7 -- int10--------
    rs1900862471,2
    --20201868(+) AGACAA/GAATCT 7 -- int10--------
    rs1818237101,2
    --20201887(+) GGAACG/TTAGAG 7 -- int10--------
    rs170066841,2
    C,F,H--20201928(+) CTGAAA/CGATTA 7 -- int117Minor allele frequency- C:0.07NA NS EA 2262
    rs126309291,2
    C,H--20202053(+) TGTAGA/G/TGTGAG 7 -- int10--------
    rs1501471881,2
    --20202112(+) TAAGAC/GAAATA 7 -- ut310--------
    rs1896552181,2
    --20202183(+) GATTTA/TAAAAA 7 -- ut310--------

    HapMap Linkage Disequilibrium report for SGOL1 (20202085 - 20227784 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SGOL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422249CNV Deletion17116639
    nsv876597CNV Loss21882294
    nsv470450CNV Loss18288195
    nsv834627CNV Loss17160897
    esv35078CNV Gain17911159
    nsv433359CNV Gain18776910
    esv23068CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609168    OMIM disorders: --

    1 disease for SGOL1:    
    About MalaCards
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for SGOL1:
    Chagas disease

    Find genes that share disorders with SGOL1           About GenesLikeMe

    Genetic Association Database (GAD): SGOL1
    Human Genome Epidemiology (HuGE) Navigator: SGOL1 (1 document)

    Export disorders for SGOL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SGOL1 gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with SGOL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (PubMed id 12747765)1, 2, 3 Scanlan M.J.... Old L.J. (Cancer Immun. 2001)
    2. Differential subcellular localizations of two human Sgo1 isoforms: implications in regulation of sister chromatid cohesion and microtubule dynamics. (PubMed id 16582621)1, 2, 9 Wang X.... Dai W. (Cell Cycle 2006)
    3. Multiple anaphase-promoting complex/cyclosome degrons mediate the degradation of human Sgo1. (PubMed id 19015261)1, 2, 9 Karamysheva Z.... Yu H. (J. Biol. Chem. 2009)
    4. PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. (PubMed id 16580887)1, 2, 9 Tang Z.... Yu H. (Dev. Cell 2006)
    5. Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis. (PubMed id 15604152)1, 2, 9 Tang Z.... Yu H. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    6. Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci. (PubMed id 22365631)1, 4 Greenwood T.A....Kelsoe J.R. (Biol. Psychiatry 2012)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1. (PubMed id 18331714)1, 2 Wang X....Dai W. (Dev. Cell 2008)
    9. Phosphorylation of human Sgo1 by NEK2A is essential for chromosome congression in mitosis. (PubMed id 17621308)1, 2 Fu G....Yao X. (Cell Res. 2007)
    10. Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1. (PubMed id 17617734)1, 2 Pouwels J.... Kallio M.J. (Cell Cycle 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 151648 HGNC: 25088 AceView: SGOL1 Ensembl:ENSG00000129810 euGenes: HUgn151648
    ECgene: SGOL1 Kegg: 151648 H-InvDB: SGOL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SGOL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SGOL1 gene:
    Search GeneIP for patents involving SGOL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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