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Aliases for SGK494 Gene

Aliases for SGK494 Gene

  • Uncharacterized Serine/Threonine-Protein Kinase SgK494 3 5
  • Sugen Kinase 494 4
  • EC 4

External Ids for SGK494 Gene

Previous GeneCards Identifiers for SGK494 Gene

  • GC17M026930
  • GC17M023143
  • GC17M026907
  • GC17M026939
  • GC17M026992
  • GC17M027138

Summaries for SGK494 Gene

GeneCards Summary for SGK494 Gene

SGK494 (Uncharacterized Serine/Threonine-Protein Kinase SgK494) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RPS6KB2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGK494 Gene

Genomics for SGK494 Gene

Regulatory Elements for SGK494 Gene

Enhancers for SGK494 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SGK494 on UCSC Golden Path with GeneCards custom track

Genomic Location for SGK494 Gene

28,607,964 bp from pter
28,614,200 bp from pter
6,237 bases
Minus strand

Genomic View for SGK494 Gene

Genes around SGK494 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGK494 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGK494 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGK494 Gene

Proteins for SGK494 Gene

  • Protein details for SGK494 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized serine/threonine-protein kinase SgK494
    Protein Accession:
    Secondary Accessions:
    • B4DFP4
    • Q49A48

    Protein attributes for SGK494 Gene

    274 amino acids
    Molecular mass:
    31044 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SGK494 Gene


neXtProt entry for SGK494 Gene

Post-translational modifications for SGK494 Gene

No Post-translational modifications

Other Protein References for SGK494 Gene

No data available for DME Specific Peptides for SGK494 Gene

Domains & Families for SGK494 Gene

Gene Families for SGK494 Gene


Protein Domains for SGK494 Gene

Suggested Antigen Peptide Sequences for SGK494 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with SGK494: view

Function for SGK494 Gene

Molecular function for SGK494 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for SGK494 Gene

Gene Ontology (GO) - Molecular Function for SGK494 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with SGK494: view
genes like me logo Genes that share phenotypes with SGK494: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SGK494 Gene

Localization for SGK494 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SGK494 Gene

Pathways & Interactions for SGK494 Gene

SuperPathways for SGK494 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SGK494 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with SGK494: view

No data available for Pathways by source and SIGNOR curated interactions for SGK494 Gene

Drugs & Compounds for SGK494 Gene

No Compound Related Data Available

Transcripts for SGK494 Gene

mRNA/cDNA for SGK494 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SGK494 Gene

Uncharacterized serine/threonine-protein kinase SgK494:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SGK494 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: -
SP6: - - - - - - - - -

Relevant External Links for SGK494 Gene

GeneLoc Exon Structure for

Expression for SGK494 Gene

mRNA expression in normal human tissues for SGK494 Gene

Protein differential expression in normal tissues from HIPED for SGK494 Gene

This gene is overexpressed in Platelet (45.5) and Cerebrospinal fluid (20.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SGK494 Gene

Protein tissue co-expression partners for SGK494 Gene

SOURCE GeneReport for Unigene cluster for SGK494 Gene:

genes like me logo Genes that share expression patterns with SGK494: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SGK494 Gene

Orthologs for SGK494 Gene

This gene was present in the common ancestor of animals.

Orthologs for SGK494 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SGK494 34
  • 89.28 (n)
  • 87.53 (a)
-- 35
  • 83 (a)
(Canis familiaris)
Mammalia SGK494 34
  • 88.69 (n)
  • 86.28 (a)
-- 35
  • 85 (a)
(Mus musculus)
Mammalia BC030499 34
  • 87.66 (n)
  • 85.64 (a)
BC030499 16
BC030499 35
  • 81 (a)
(Pan troglodytes)
Mammalia LOC737514 34
  • 99.11 (n)
  • 98.78 (a)
-- 35
  • 99 (a)
(Rattus norvegicus)
Mammalia Sgk494 34
  • 86.61 (n)
  • 85.3 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 70 (a)
(Gallus gallus)
Aves -- 35
  • 76 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494554 34
  • 62.57 (n)
  • 62.03 (a)
(Danio rerio)
Actinopterygii LOC101883587 34
  • 60.12 (n)
  • 55.95 (a)
sgk494b 35
  • 43 (a)
si:dkeyp-118e10.5 35
  • 44 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pk17E 35
  • 26 (a)
(Caenorhabditis elegans)
Secernentea F31E3.2 34
  • 49 (n)
  • 42.4 (a)
F31E3.2 35
  • 31 (a)
Species where no ortholog for SGK494 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SGK494 Gene

Gene Tree for SGK494 (if available)
Gene Tree for SGK494 (if available)

Paralogs for SGK494 Gene

genes like me logo Genes that share paralogs with SGK494: view

Variants for SGK494 Gene

Structural Variations from Database of Genomic Variants (DGV) for SGK494 Gene

Variant ID Type Subtype PubMed ID
nsv1064087 CNV gain 25217958
nsv482200 CNV loss 20164927

Variation tolerance for SGK494 Gene

Gene Damage Index Score: 2.27; 40.65% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for SGK494 Gene

Disorders for SGK494 Gene

No disorders were found for SGK494 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for SGK494 Gene

Publications for SGK494 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. The protein kinase complement of the human genome. (PMID: 12471243) Manning G. … Sudarsanam S. (Science 2002) 3 4 65
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 65
  5. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E. … Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 65

Products for SGK494 Gene

Sources for SGK494 Gene

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