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SGK494 Gene

protein-coding   GIFtS: 31
GCID: GC17M027138

Uncharacterized Serine/Threonine-Protein Kinase SgK494


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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sugen Kinase 4942 3
Uncharacterized Serine/Threonine-Protein Kinase SgK4942
EC 2.7.11.13

External Ids:    Entrez Gene: 1249232   Ensembl: ENSG000001675247   UniProtKB: Q96LW23   

Export aliases for SGK494 gene to outside databases

Previous GC identifers: GC17M026930 GC17M023143 GC17M026907 GC17M026939 GC17M026992


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SGK494 Gene:
SGK494 is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is STK32B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for SGK494
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SGK494

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SGK494


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   

SGK494 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SGK494 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M027138:  view genomic region     (about GC identifiers)

Start:
26,934,982 bp from pter      End:
26,941,218 bp from pter
Size:
6,237 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SG494_HUMAN, Q96LW2 (See protein sequence)
Recommended Name: Uncharacterized serine/threonine-protein kinase SgK494  
Size: 274 amino acids; 31044 Da
Secondary accessions: B4DFP4 Q49A48
Alternative splicing: 2 isoforms:  Q96LW2-1   Q96LW2-2   

Explore the universe of human proteins at neXtProt for SGK494: NX_Q96LW2

Explore proteomics data for SGK494 at MOPED


See SGK494 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001167574.1  NP_001274136.1  

ENSEMBL proteins: 
 ENSP00000463890   ENSP00000468448   ENSP00000301037   ENSP00000434603   ENSP00000464010  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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IUPHAR Guide to PHARMACOLOGY protein family classification: SGK494
RSKR subfamily
Other AGC kinases

3 InterPro protein domains:
 IPR011009 Kinase-like_dom
 IPR008271 Ser/Thr_kinase_AS
 IPR000719 Prot_kinase_dom

Graphical View of Domain Structure for InterPro Entry Q96LW2

ProtoNet protein and cluster: Q96LW2

UniProtKB/Swiss-Prot: SG494_HUMAN, Q96LW2
Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family
Similarity: Contains 1 protein kinase domain


Find genes that share domains with SGK494           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: SG494_HUMAN, Q96LW2
Catalytic activity: ATP + a protein = ADP + a phosphoprotein

     Enzyme Number (IUBMB): EC 2.7.11.11

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004672protein kinase activity ----
GO:0004674protein serine/threonine kinase activity IEA--
GO:0004713protein tyrosine kinase activity ----
GO:0005524ATP binding IEA--
GO:0016772transferase activity, transferring phosphorus-containing groups ----
     
Find genes that share ontologies with SGK494           About GenesLikeMe


Phenotypes:
     3 GenomeRNAi human phenotypes for SGK494:
 Actin fiber cells  Decreased focal adhesion (FA)   Decreased substrate adherent c 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for SGK494

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane2
cytosol1
endoplasmic reticulum1
extracellular1
mitochondrion1
nucleus1
peroxisome1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SGK494
Interactions:

    Search GeneGlobe Interaction Network for SGK494

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for SGK494 (Q96LW23 ENSP000003010374) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
InteractantInteraction Details
GeneCardExternal ID(s)
PSTPIP1O435863, ENSP000003689144I2D: score=1 STRING: ENSP00000368914
APLP2ENSP000002635744STRING: ENSP00000263574
APPENSP000002849814STRING: ENSP00000284981
PIGGENSP000004152034STRING: ENSP00000415203
APLP1ENSP000002218914STRING: ENSP00000221891
About this table

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006468protein phosphorylation ----

Find genes that share ontologies with SGK494           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SGK494 (SG494)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for SGK494 gene (3 alternative transcripts): 
NM_144610.1  NM_001174103.1  NM_001287207.1  

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000579457 ENST00000578956 ENST00000494272 ENST00000301037(uc010crq.2)
ENST00000581199(uc021ttt.1) ENST00000526073 ENST00000461399 ENST00000527918
ENST00000530121 ENST00000469832 ENST00000527863 ENST00000525510
miRNA
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hsa-miR-3194-5p hsa-miR-137 hsa-miR-29c hsa-miR-29a hsa-miR-1273d hsa-miR-629* hsa-miR-641 hsa-miR-548x
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGK494
Addgene plasmids for SGK494 
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16 AceView cDNA sequences:

H19001 AI699883 AI383263 BI546006 AK057735 BQ082279 NM_144610 BF954472 
BE968821 AW860225 BG656290 BF825420 BF812397 BG986157 H19102 BF377561 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for SGK494 (see all 6)    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:              -                             -                                 
SP2:              -                             -     -     -                     
SP3:              -                       -     -                                 
SP4:              -                                                               
SP5:                                            -                                 



(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SGK494 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
SGK494 Expression
About this image

SGK494 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SGK494 Protein Expression
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGK494

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for SGK494 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia BC0304991 , 5 cDNA sequence BC0304991, 5 87.66(n)1
85.64(a)1
  11 (46.74 cM)5
2169761  NM_001287206.11  NP_001274135.11 
 782908415 
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
76(a)
1 ↔ 1
19(5749123-5751483)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
47(a)
1 ↔ 1
GL344005.1(111404-112460)
tropical clawed frog
(Xenopus tropicalis)
Amphibia LOC1004945541 uncharacterized LOC100494554 62.57(n)
62.03(a)
  100494554  XM_002937626.2  XP_002937672.2 
zebrafish
(Danio rerio)
Actinopterygii LOC1018835871 putative serine/threonine-protein kinase F31E3.2-like 60.12(n)
55.95(a)
  101883587  XM_005157443.1  XP_005157500.1 
fruit fly
(Drosophila melanogaster)
Insecta Pk17E6
Protein kinase-like 17E
26(a)
1 ↔ 1
X(18682499-18700090)
worm
(Caenorhabditis elegans)
Secernentea F31E3.21 F31E3.2 49(n)
42.4(a)
  175977  NM_001027386.3  NP_001022557.1 


ENSEMBL Gene Tree for SGK494 (if available)
TreeFam Gene Tree for SGK494 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SGK494 gene
STK32B2  STK32C2  STK32A2  
Selected SIMAP similar genes for SGK494 using alignment to 6 protein entries:     SG494_HUMAN (see all proteins) (see all similar genes):
STK38L    PRKCH    RPS6KA2    MARK4    PKN2    RPS6KA1
NEK8    ULK1    RPS6KA6    RPS6KA3    BRAF    PRKY
STK25    PRKACG    STK32A    STK36    CDK1    MAP4K5

Find genes that share paralogs with SGK494           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Structural Variations
     Database of Genomic Variants (DGV) 1 variation for SGK494:    About this table    
Variant IDTypeSubtypePubMed ID
nsv482200CNV Loss20164927

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SGK494
DNA2.0 Custom Variant and Variant Library Synthesis for SGK494

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SGK494 gene integrated from 10 sources:
(articles sorted by number of sources associating them with SGK494)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. The protein kinase complement of the human genome. (PubMed id 12471243)1, 2 Manning G.... Sudarsanam S. (Science 2002)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  5. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 124923 AceView: FLJ25006 Ensembl:ENSG00000167524 euGenes: HUgn124923

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SGK494 gene:
Search GeneIP for patents involving SGK494

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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