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Aliases for SGK494 Gene

Aliases for SGK494 Gene

  • Uncharacterized Serine/Threonine-Protein Kinase SgK494 3
  • Sugen Kinase 494 4
  • EC 2.7.11.1 4

External Ids for SGK494 Gene

Previous GeneCards Identifiers for SGK494 Gene

  • GC17M026930
  • GC17M023143
  • GC17M026907
  • GC17M026939
  • GC17M026992
  • GC17M027138

Summaries for SGK494 Gene

GeneCards Summary for SGK494 Gene

SGK494 (Uncharacterized Serine/Threonine-Protein Kinase SgK494) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is STK32B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGK494 Gene

Genomics for SGK494 Gene

Genomic Location for SGK494 Gene

Start:
28,607,964 bp from pter
End:
28,614,340 bp from pter
Size:
6,377 bases
Orientation:
Minus strand

Genomic View for SGK494 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SGK494 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGK494 Gene

No data available for Regulatory Elements for SGK494 Gene

Proteins for SGK494 Gene

  • Protein details for SGK494 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LW2-SG494_HUMAN
    Recommended name:
    Uncharacterized serine/threonine-protein kinase SgK494
    Protein Accession:
    Q96LW2
    Secondary Accessions:
    • B4DFP4
    • Q49A48

    Protein attributes for SGK494 Gene

    Size:
    274 amino acids
    Molecular mass:
    31044 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SGK494 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SGK494 Gene

Proteomics data for SGK494 Gene at MOPED

Post-translational modifications for SGK494 Gene

No Post-translational modifications

Other Protein References for SGK494 Gene

No data available for DME Specific Peptides for SGK494 Gene

Domains for SGK494 Gene

Gene Families for SGK494 Gene

Protein Domains for SGK494 Gene

Suggested Antigen Peptide Sequences for SGK494 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96LW2

UniProtKB/Swiss-Prot:

SG494_HUMAN :
  • Q96LW2
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with SGK494: view

Function for SGK494 Gene

Molecular function for SGK494 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB) for SGK494 Gene

Gene Ontology (GO) - Molecular Function for SGK494 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with SGK494: view

Phenotypes for SGK494 Gene

genes like me logo Genes that share phenotypes with SGK494: view

Animal Model Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SGK494 Gene

Localization for SGK494 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SGK494 Gene COMPARTMENTS Subcellular localization image for SGK494 gene
Compartment Confidence
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SGK494 Gene

Pathways for SGK494 Gene

SuperPathways for SGK494 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SGK494 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with SGK494: view

No data available for Pathways by source for SGK494 Gene

Transcripts for SGK494 Gene

mRNA/cDNA for SGK494 Gene

(16) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SGK494 Gene

Uncharacterized serine/threonine-protein kinase SgK494:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SGK494

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SGK494 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: -
SP6: - - - - - - - - -

Relevant External Links for SGK494 Gene

GeneLoc Exon Structure for
SGK494

Expression for SGK494 Gene

mRNA expression in normal human tissues for SGK494 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SGK494 Gene

SOURCE GeneReport for Unigene cluster for SGK494 Gene Hs.729077

genes like me logo Genes that share expressions with SGK494: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SGK494 Gene

Orthologs for SGK494 Gene

This gene was present in the common ancestor of animals.

Orthologs for SGK494 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
OneToOne
LOC737514 35
  • 99.11 (n)
  • 98.78 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 83 (a)
OneToOne
SGK494 35
  • 89.28 (n)
  • 87.53 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 85 (a)
OneToOne
SGK494 35
  • 88.69 (n)
  • 86.28 (a)
mouse
(Mus musculus)
Mammalia BC030499 35
  • 87.66 (n)
  • 85.64 (a)
BC030499 16
BC030499 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sgk494 35
  • 86.61 (n)
  • 85.3 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494554 35
  • 62.57 (n)
  • 62.03 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101883587 35
  • 60.12 (n)
  • 55.95 (a)
sgk494b 36
  • 43 (a)
OneToMany
si:dkeyp-118e10.5 36
  • 44 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Pk17E 36
  • 26 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F31E3.2 35
  • 49 (n)
  • 42.4 (a)
F31E3.2 36
  • 31 (a)
OneToOne
Species with no ortholog for SGK494:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SGK494 Gene

ENSEMBL:
Gene Tree for SGK494 (if available)
TreeFam:
Gene Tree for SGK494 (if available)

Paralogs for SGK494 Gene

Paralogs for SGK494 Gene

genes like me logo Genes that share paralogs with SGK494: view

Variants for SGK494 Gene

Structural Variations from Database of Genomic Variants (DGV) for SGK494 Gene

Variant ID Type Subtype PubMed ID
nsv482200 CNV Loss 20164927

Relevant External Links for SGK494 Gene

HapMap Linkage Disequilibrium report
SGK494

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for SGK494 Gene

Disorders for SGK494 Gene

No disorders were found for SGK494 Gene.

No data available for UniProtKB/Swiss-Prot for SGK494 Gene

Publications for SGK494 Gene

  1. The protein kinase complement of the human genome. (PMID: 12471243) Manning G. … Sudarsanam S. (Science 2002) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E. … Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3

Products for SGK494 Gene

Sources for SGK494 Gene

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