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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SGK3 Gene

protein-coding   GIFtS: 63
GCID: GC08P067624

Serum/Glucocorticoid Regulated Kinase Family, Member 3

(Previous name: serum/glucocorticoid regulated kinase-like)
(Previous symbols: SGK2, SGKL)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serum/Glucocorticoid Regulated Kinase Family, Member 31 2     Serum/Glucocorticoid Regulated Kinase-Like1
SGKL1 2 3 5     Serine/Threonine-Protein Kinase Sgk32
CISK2 3 5     Serum/Glucocorticoid-Regulated Kinase 33
SGK21 2     Serum/Glucocorticoid-Regulated Kinase-Like3
Cytokine-Independent Survival Kinase2 3     EC 2.7.118
EC 2.7.11.13 8     

External Ids:    HGNC: 108121   Entrez Gene: 236782   Ensembl: ENSG000001042057   OMIM: 6075915   UniProtKB: Q96BR13   

Export aliases for SGK3 gene to outside databases

Previous GC identifers: GC08P067851 GC08P063176


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SGK3 Gene:
This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology)
domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and
activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different
isoforms, have been characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for SGK3 Gene: 
SGK3 (serum/glucocorticoid regulated kinase family, member 3) is a protein-coding gene. Diseases associated with SGK3 include bone density, and gastric cancer, and among its related super-pathways are Stimuli-sensing channels and SLC-mediated transmembrane transport. An important paralog of this gene is RPS6KA6.

UniProtKB/Swiss-Prot: SGK3_HUMAN, Q96BR1
Function: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels,
membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels:
SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5
and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter:
SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2
and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors:
GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the
regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively
regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of
ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes

Gene Wiki entry for SGK3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008183.19  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SGK3 gene promoter:
         GR   NF-1/L   NF-1   GATA-3   Brachyury   GR-beta   GATA-1   GATA-2   GR-alpha   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SGK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SGK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SGK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q12   Ensembl cytogenetic band:  8q13.1   HGNC cytogenetic band: 8q12

SGK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SGK3 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P067624:  view genomic region     (about GC identifiers)

Start:
67,624,653 bp from pter      End:
67,774,257 bp from pter
Size:
149,605 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SGK3_HUMAN, Q96BR1 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase Sgk3  
Size: 496 amino acids; 57108 Da
Subunit: Interacts with GSK3B and FLII. Interacts with PDPK1 in a phosphorylation-dependent manner
Subcellular location: Cytoplasmic vesicle (By similarity). Early endosome. Recycling endosome. Note=Endosomal
localization is a prerequisite for complete kinase activity. It is essential for its co-localization with the
kinase responsible for phosphorylating Ser-486 thus allowing PDPK1 phosphorylation of Thr-320 resulting in
complete activation of SGK3. Localized in vesicle-like structures and in the early endosome. Co-localizes with
SLC9A3/NHE3 in the recycling endosomes
Sequence caution: Sequence=AAF12758.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K5W3 B3KQC2 Q9P1Q7 Q9UKG5
Alternative splicing: 2 isoforms:  Q96BR1-1   Q96BR1-2   

Explore the universe of human proteins at neXtProt for SGK3: NX_Q96BR1

Explore proteomics data for SGK3 at MOPED 

Post-translational modifications:

  • UniProtKB: Activated by phosphorylation on Ser-486 by an unknown kinase (may be mTORC2 but not confirmed), transforming it
    into a substrate for PDPK1 which then phosphorylates it on Thr-320
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96BR1

  • 4/12 DME Specific Peptides for SGK3 (Q96BR1) (see all 12)
     FYAAEIA  VNGGELF  RDLKPEN  DFGLCKE 

    SGK3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SGK3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001028750.1  NP_037389.4  NP_733827.2  

    ENSEMBL proteins: 
     ENSP00000430463   ENSP00000430475   ENSP00000430256   ENSP00000429606   ENSP00000430691  
     ENSP00000428972   ENSP00000331816   ENSP00000428529   ENSP00000429565   ENSP00000379842  
    Reactome Protein details: Q96BR1
    Human Recombinant Protein Products for SGK3: 
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    OriGene MassSpec for SGK3 
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    GenScript Custom Purified and Recombinant Proteins Services for SGK3
    Novus Biologicals SGK3 Proteins
    Novus Biologicals SGK3 Lysates
    Sino Biological Recombinant Protein for SGK3
    Sino Biological Cell Lysate for SGK3 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SGK3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005769early endosome ----
    GO:0005829cytosol ----
    GO:0016023cytoplasmic membrane-bounded vesicle ----
    GO:0055037recycling endosome ----

    SGK3 for ontologies           About GeneDecksing



    SGK3 Antibody Products: 
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    Assay Products for SGK3: 
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    Cloud-Clone Corp. ELISAs for SGK3 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: serum/glucocorticoid regulated kinase family, member 3 
    SGK family
    Other AGC kinases

    5/8 InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR001683 Phox
     IPR000961 AGC-kinase_C
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q96BR1

    ProtoNet protein and cluster: Q96BR1

    2 Blocks protein domains:
    IPB000961 Protein kinase C-terminal domain
    IPB001683 Phox-like


    UniProtKB/Swiss-Prot: SGK3_HUMAN, Q96BR1
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 PX (phox homology) domain


    SGK3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SGK3_HUMAN, Q96BR1
    Function: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels,
    membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels:
    SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5
    and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter:
    SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2
    and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors:
    GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the
    regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively
    regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of
    ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Two specific sites, one in the kinase domain (Thr-320) and the other in the C-terminal
    regulatory region (Ser-486), need to be phosphorylated for its full activation
    Induction: Induced by estrogen/ER in breast cancer cells

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0005246calcium channel regulator activity ----
    GO:0005515protein binding ----
         
    SGK3 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for SGK3:
     Decreased focal adhesion (FA)   Decreased mitotic index  Decreased substrate adherent c  Increased cell death HMECs cel 
     Weaker migration 

         4 MGI mutant phenotypes (inferred from 10 alleles(MGI details for Sgk3):
     growth/size  homeostasis/metabolism  immune system  integument 

    SGK3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SGK3: Sgk3tm1Dpea Sgk3tm1Efu

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SGK3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SGK3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SGK3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SGK3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SGK3
    8/81 QIAGEN miScript miRNA Assays for microRNAs that regulate SGK3 (see all 81):
    hsa-miR-100* hsa-miR-300 hsa-miR-199a-3p hsa-miR-30d hsa-miR-550a* hsa-miR-3916 hsa-miR-3122 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidSGK3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): SGK3 (NM_013257)
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                         Customized lentivirus expression plasmids for stable overexpression of SGK3 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGK3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SGK3 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.49
    Stimuli-sensing channels0.49
    2SLC-mediated transmembrane transport
    Transmembrane transport of small molecules0.50
    3Selected targets of ESR1
    Selected targets of ESR1
    4PI3K / Akt Signaling
    PI3K / Akt Signaling
    5Insulin Signaling
    Insulin Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for SGK3
        Selected targets of ESR1


    1 Cell Signaling Technology (CST) Pathway for SGK3
        PI3K / Akt Signaling

    1 BioSystems Pathway for SGK3
        Insulin Signaling


    3        Reactome Pathways for SGK3
        Transmembrane transport of small molecules
    Stimuli-sensing channels
    Ion channel transport


    1         Kegg Pathway  (Kegg details for SGK3):
        PI3K-Akt signaling pathway


    SGK3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SGK3

    5/7 Interacting proteins for SGK3 (Q96BR12, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITCHQ96J022, 3MINT-2881316 MINT-2881371 MINT-2879884 MINT-2881283 MINT-2881346 I2D: score=1 
    PDK1Q151182, 3MINT-2881442 MINT-2881402 I2D: score=1 
    GSK3BP498413I2D: score=2 
    ESR1P033723I2D: score=1 
    GSK3AP498403I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth ----
    GO:0006468protein phosphorylation ----
    GO:0006950response to stress ----
    GO:0007154cell communication ----
    GO:0030334regulation of cell migration ----

    SGK3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SGK3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for SGK3

    Browse Tocris compounds for SGK3

    2 HMDB Compounds for SGK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    8 Novoseek inferred chemical compound relationships for SGK3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 47.3 4 17167223 (1), 11050396 (1), 16485113 (1), 18464067 (1)
    phosphatidylinositol 45 14 19293151 (3), 10548550 (1), 17015487 (1), 11514587 (1) (see all 5)
    threonine 38.1 1 11050396 (1)
    alanine 28.3 2 17167223 (1), 16485113 (1)
    glutamate 19.9 6 16485113 (2), 12911626 (1), 18464067 (1), 16573659 (1)
    glutamine 16.9 1 12788082 (1)
    glucose 8.8 5 15166308 (2), 17051390 (1)
    lipid 0 2 17356130 (1), 11514587 (1)

    Search CenterWatch for drugs/clinical trials and news about SGK3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SGK3 gene (3 alternative transcripts): 
    NM_001033578.2  NM_013257.4  NM_170709.2  

    Unigene Cluster for SGK3:

    Serum/glucocorticoid regulated kinase family, member 3
    Hs.613417  [show with all ESTs]
    Unigene Representative Sequence: NM_001204173
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521198 ENST00000523401 ENST00000494528 ENST00000521960 ENST00000522398
    ENST00000522629 ENST00000520976 ENST00000518388 ENST00000345714(uc003xwp.3)
    ENST00000519396 ENST00000521152 ENST00000521435 ENST00000523260 ENST00000396596(uc003xwt.3 uc003xwu.3)

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGK3
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SGK3

    Additional mRNA sequence: 

    AF169035.1 AK074666.1 AK223523.1 AK291428.1 BC015326.1 CR536581.1 CR933673.1 

    10 DOTS entries:

    DT.101975314  DT.421957  DT.40128432  DT.95157161  DT.95157162  DT.99969225  DT.100683780  DT.91852082 
    DT.95337629  DT.97788047 

    24/139 AceView cDNA sequences (see all 139):

    NM_170709 CD722716 AW051671 BQ960013 AW779720 BQ787765 AI375182 AU138726 
    BQ777590 AW517511 BQ181443 CR536581 AK074666 AW770240 N94726 AA884846 
    BU557817 BU626531 BQ787582 AI161430 BC015326 AA211107 BF665552 AI127772 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SGK3 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16
    SP1:                                -                                                                                 
    SP2:        -     -                 -                                                                                 
    SP3:                                                                                -                                 
    SP4:                                -                                                                                 
    SP5:              -                 -                                                                                 


    ECgene alternative splicing isoforms for SGK3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SGK3 expression in normal human tissues (normalized intensities)      SGK3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGTCTTGA
    SGK3 Expression
    About this image


    SGK3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/46 selected tissues (see all 46) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
             ganglion/cranial   
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             monocytes   
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             heart muscle ; myocytes   
             heart/ventricle   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Lung (Respiratory System)    fully expand to see all 4 entries
             Stem Bronchi
             bronchus ; respiratory epithelial cells   

    See SGK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SGK3

    SOURCE GeneReport for Unigene cluster: Hs.613417

    UniProtKB/Swiss-Prot: SGK3_HUMAN, Q96BR1
    Tissue specificity: Expressed in most tissues with highest levels in pancreas, kidney liver, heart and brain and
    lower levels in lung, placenta and skeletal muscle. Expression is higher in ER-positive breast tumors than
    ER-negative breast tumors

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SGK3 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sgk31 , 5 serum/glucocorticoid regulated kinase 31, 5 90.39(n)1
    96.77(a)1
      1 (2.08 cM)5
    1707551  NM_001037759.11  NP_001032848.11 
     97981305 
    chicken
    (Gallus gallus)
    Aves SGK31 serum/glucocorticoid regulated kinase family, member more 84.19(n)
    93.87(a)
      420167  NM_001030940.1  NP_001026111.1 
    lizard
    (Anolis carolinensis)
    Reptilia SGK36
    Uncharacterized protein
    92(a)
    1 → many
    4(30940678-31007924)
    zebrafish
    (Danio rerio)
    Actinopterygii sgk31 serum/glucocorticoid regulated kinase family, member more 72.22(n)
    79.01(a)
      564523  NM_001110467.1  NP_001103937.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sgk-16
    Serine/threonine-protein kinase sgk-1
    45(a)
    1 → many
    X(16254840-16262129)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YPK16
    YPK26
    Serine/threonine protein kinase that phosphorylate...
    Protein kinase with similarity to serine/threonine...
    27(a)
    27(a)
    many ↔ many
    many ↔ many
    XI(205707-207749)
    XIII(473420-475453)


    ENSEMBL Gene Tree for SGK3 (if available)
    TreeFam Gene Tree for SGK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SGK3 gene
    C8orf44-SGK31 2  RPS6KA62  AKT12  RPS6KB12  RPS6KA12  SGK22  RPS6KA52  AKT32  
    RPS6KA42  SGK12  RPS6KB22  RPS6KA22  RPS6KA32  AKT22  
    18/57 SIMAP similar genes for SGK3 using alignment to 6 protein entries:     SGK3_HUMAN (see all proteins) (see all similar genes):
    DKFZp781N0293    SGKL    SGK2    DMPK    SGK1    PRKACA
    NEK5    AKT1    MAST4    RPS6KB2    RPS6KA2    AKT2
    CAMK1D    CIT    PRKY    RPS6KA5    PRKACB    RPS6KB1

    SGK3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    8 SNPs in SGK3 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356364
    A breast cancer sample4--see VAR_0356362 A V mis40--------
    VAR_0410764
    ----see VAR_0410762 L P mis40--------
    rs1995825721,2
    --67656748(+) TATAT-/AT    
       ATATA
    TTTTT
    1 -- int10--------
    rs352843931,2
    C--67701358(+) AAAAA-/A/AA  
            
    CACTA
    1 -- int12NA 4
    rs358646321,2
    ----67623370(+) GTGTT-/GT    
       
    /GTGT
    CTTCA
    1 -- us2k10--------
    rs712475021,2
    ----67635367(+) TATATATATTT/-
            
    TTTTT
    1 -- cds11Minor allele frequency- -:0.00NA 2
    rs712475011,2
    ----67623369(+) TGTGTGT/-TCTTC 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1998877391,2
    ----67699161(+) CTGTC-/TTTTTTT
    TTTTTTTTTT
    TTTTT
    1 -- int10--------

    HapMap Linkage Disequilibrium report for SGK3 (67624653 - 67774257 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SGK3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2675141CNV Deletion23128226
    esv2062022CNV Deletion18987734
    nsv6239CNV Insertion18451855
    esv2466698CNV Insertion19546169
    esv1319586CNV Insertion17803354
    nsv6238CNV Insertion18451855
    nsv831346CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607591    OMIM disorders: --

    4 diseases for SGK3:    About MalaCards
    bone density    gastric cancer    hepatocellular carcinoma    breast cancer


    SGK3 for disorders           About GeneDecksing


    Export disorders for SGK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SGK3 gene, integrated from 9 sources (see all 66):
    (articles sorted by number of sources associating them with SGK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. (PubMed id 10548550)1, 2, 3, 9 Kobayashi T.... Cohen P. (1999)
    2. Cloning and mapping of a novel human Serum/Glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1. (PubMed id 10585774)1, 2, 3, 9 Dai F.... Zhao S. (1999)
    3. Identification of Flightless-I as a Substrate of the Cytokine-independent Survival Kinase CISK. (PubMed id 19293151)1, 2, 9 Xu J....Songyang Z. (2009)
    4. Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms. (PubMed id 12590200)1, 2, 9 Henke G....Lang F. (2002)
    5. Peroxisomal targeting as a tool for assaying potein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner. (PubMed id 14604990)1, 2, 9 Nilsen T....Olsnes S. (2004)
    6. Regulation of CLC-Ka/barttin by the ubiquitin ligase Nedd4-2 and the serum- and glucocorticoid-dependent kinases. (PubMed id 15496163)1, 2, 9 Embark H.M....Lang F. (2004)
    7. Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms. (PubMed id 12634932)1, 2, 9 Embark H.M....Lang F. (2003)
    8. K(+) channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK. (PubMed id 12397388)1, 2, 9 Gamper N.... Lang F. (2002)
    9. Upregulation of HERG channels by the serum and glucocorticoid inducible kinase isoform SGK3. (PubMed id 17167223)1, 2, 9 Maier G....Lang F. (2006)
    10. Stimulation of the creatine transporter SLC6A8 by the protein kinases SGK1 and SGK3. (PubMed id 16036218)1, 2, 9 Shojaiefard M....Lang F. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23678 HGNC: 10812 AceView: SGKLandFLJ11267 Ensembl:ENSG00000104205 euGenes: HUgn23678
    ECgene: SGK3 Kegg: 23678 H-InvDB: SGK3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SGK3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SGK3 gene:
    Search GeneIP for patents involving SGK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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