Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SGK3 Gene

Aliases for SGK3 Gene

  • Serum/Glucocorticoid Regulated Kinase Family Member 3 2 3 5
  • Cytokine-Independent Survival Kinase 3 4
  • EC 2.7.11.1 4 61
  • SGKL 3 4
  • CISK 3 4
  • Serum/Glucocorticoid Regulated Kinase Family, Member 3 2
  • Serum/Glucocorticoid Regulated Kinase-Like 2
  • Serum/Glucocorticoid-Regulated Kinase-Like 4
  • Serum/Glucocorticoid-Regulated Kinase 3 4
  • Serine/Threonine-Protein Kinase Sgk3 3
  • EC 2.7.11 61
  • SGK2 3

External Ids for SGK3 Gene

Previous HGNC Symbols for SGK3 Gene

  • SGK2
  • SGKL

Previous GeneCards Identifiers for SGK3 Gene

  • GC08P067851
  • GC08P067624
  • GC08P063176

Summaries for SGK3 Gene

Entrez Gene Summary for SGK3 Gene

  • This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for SGK3 Gene

SGK3 (Serum/Glucocorticoid Regulated Kinase Family Member 3) is a Protein Coding gene. Among its related pathways are Ion channel transport and FoxO signaling pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is C8orf44-SGK3.

UniProtKB/Swiss-Prot for SGK3 Gene

  • Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.

Gene Wiki entry for SGK3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGK3 Gene

Genomics for SGK3 Gene

Regulatory Elements for SGK3 Gene

Enhancers for SGK3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F066783 1.2 FANTOM5 Ensembl ENCODE 10.5 +72.7 72683 2.6 GATAD2A SAP130 FOXA3 CEBPB CEBPG RAD21 SPI1 SGK3 C8orf44 GC08M066750 PTTG3P
GH08F066781 1.1 FANTOM5 Ensembl ENCODE 8.5 +69.5 69484 1.8 FOSL2 SPI1 TRIM28 SGK3 C8orf44 VCPIP1 GC08M066750 PTTG3P
GH08F066787 0.7 FANTOM5 Ensembl 13.1 +75.1 75146 0.7 SGK3 PPP1R42 COPS5 CSPP1 ADHFE1 VCPIP1 GC08M066750 MCMDC2
GH08F066711 1.3 FANTOM5 ENCODE 5.6 +0.7 671 3.0 ATF1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 GLIS2 FOS MXD4 SGK3 C8orf44 VCPIP1 PTTG3P
GH08F066715 0.6 ENCODE 0.8 +3.7 3715 0.8 PKNOX1 MTA2 MAFG ZNF316 FOS NFE2 MAFK EMSY PRDM1 TCF24 SGK3 PTTG3P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SGK3 on UCSC Golden Path with GeneCards custom track

Promoters for SGK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001441855 782 2401 ATF1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 GLIS2 FOS MXD4

Genomic Location for SGK3 Gene

Chromosome:
8
Start:
66,712,418 bp from pter
End:
66,862,022 bp from pter
Size:
149,605 bases
Orientation:
Plus strand

Genomic View for SGK3 Gene

Genes around SGK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGK3 Gene

Proteins for SGK3 Gene

  • Protein details for SGK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BR1-SGK3_HUMAN
    Recommended name:
    Serine/threonine-protein kinase Sgk3
    Protein Accession:
    Q96BR1
    Secondary Accessions:
    • A8K5W3
    • B3KQC2
    • Q9P1Q7
    • Q9UKG5

    Protein attributes for SGK3 Gene

    Size:
    496 amino acids
    Molecular mass:
    57108 Da
    Quaternary structure:
    • Interacts with GSK3B and FLII. Interacts with PDPK1 in a phosphorylation-dependent manner.
    SequenceCaution:
    • Sequence=AAF12758.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SGK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SGK3 Gene

Selected DME Specific Peptides for SGK3 Gene

Q96BR1:
  • GKGSFGKV
  • GTPEYLAPE
  • NGGELFFHL
  • ERNVLLKNVKHPFLVGLH
  • FYAVKVLQKK
  • VNGGELF
  • FYAAEIA
  • VDWWCLGAVLYEML
  • RDLKPEN
  • NFDPDFIK
  • DFGLCKE
  • KPENILLD

Post-translational modifications for SGK3 Gene

  • Activated by phosphorylation on Ser-486 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-320.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SGK3 (SGK3)
  • Santa Cruz Biotechnology (SCBT) Antibodies for SGK3

Domains & Families for SGK3 Gene

Graphical View of Domain Structure for InterPro Entry

Q96BR1

UniProtKB/Swiss-Prot:

SGK3_HUMAN :
  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 protein kinase domain.
  • Contains 1 PX (phox homology) domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with SGK3: view

Function for SGK3 Gene

Molecular function for SGK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Two specific sites, one in the kinase domain (Thr-320) and the other in the C-terminal regulatory region (Ser-486), need to be phosphorylated for its full activation.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.
UniProtKB/Swiss-Prot Induction:
Induced by estrogen/ER in breast cancer cells.

Enzyme Numbers (IUBMB) for SGK3 Gene

Gene Ontology (GO) - Molecular Function for SGK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 10548550
GO:0004674 protein serine/threonine kinase activity IEA,TAS --
GO:0005246 calcium channel regulator activity TAS 16460280
GO:0005515 protein binding IPI 16888620
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with SGK3: view
genes like me logo Genes that share phenotypes with SGK3: view

Animal Models for SGK3 Gene

MGI Knock Outs for SGK3:

Animal Model Products

  • Taconic Biosciences Mouse Models for SGK3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SGK3 Gene

Localization for SGK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SGK3 Gene

Cytoplasmic vesicle. Early endosome. Recycling endosome. Note=Endosomal localization is a prerequisite for complete kinase activity. It is essential for its colocalization with the kinase responsible for phosphorylating Ser-486 thus allowing PDPK1 phosphorylation of Thr-320 resulting in complete activation of SGK3. Localized in vesicle-like structures and in the early endosome. Colocalizes with SLC9A3/NHE3 in the recycling endosomes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SGK3 gene
Compartment Confidence
cytosol 5
endosome 5
plasma membrane 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SGK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA --
GO:0005829 cytosol TAS --
GO:0031410 cytoplasmic vesicle IEA --
GO:0055037 recycling endosome IEA --
genes like me logo Genes that share ontologies with SGK3: view

Pathways & Interactions for SGK3 Gene

genes like me logo Genes that share pathways with SGK3: view

Pathways by source for SGK3 Gene

1 Cell Signaling Technology pathway for SGK3 Gene
1 BioSystems pathway for SGK3 Gene

SIGNOR curated interactions for SGK3 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for SGK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth TAS 20919962
GO:0006468 protein phosphorylation TAS 10548550
GO:0006883 cellular sodium ion homeostasis IBA --
GO:0006950 response to stress TAS 10548550
GO:0010765 positive regulation of sodium ion transport IBA --
genes like me logo Genes that share ontologies with SGK3: view

Drugs & Compounds for SGK3 Gene

(6) Drugs for SGK3 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
GSK 650394 Pharma SGK1 inhibitor, Serum- and glucocorticoid-regulated kinase (SGK) inhibitor 0

(3) Additional Compounds for SGK3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for SGK3 Gene

Compound Action Cas Number
GSK 650394 SGK1 inhibitor 890842-28-1
genes like me logo Genes that share compounds with SGK3: view

Transcripts for SGK3 Gene

Unigene Clusters for SGK3 Gene

Serum/glucocorticoid regulated kinase family, member 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SGK3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16
SP1: -
SP2: - - -
SP3: -
SP4: -
SP5: - -
SP6:
SP7:

Relevant External Links for SGK3 Gene

GeneLoc Exon Structure for
SGK3
ECgene alternative splicing isoforms for
SGK3

Expression for SGK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SGK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SGK3 Gene

This gene is overexpressed in Tlymphocyte (24.9) and Heart (22.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SGK3 Gene



Protein tissue co-expression partners for SGK3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SGK3 Gene:

SGK3

SOURCE GeneReport for Unigene cluster for SGK3 Gene:

Hs.613417

mRNA Expression by UniProt/SwissProt for SGK3 Gene:

Q96BR1-SGK3_HUMAN
Tissue specificity: Expressed in most tissues with highest levels in pancreas, kidney liver, heart and brain and lower levels in lung, placenta and skeletal muscle. Expression is higher in ER-positive breast tumors than ER-negative breast tumors.
genes like me logo Genes that share expression patterns with SGK3: view

No data available for mRNA differential expression in normal tissues for SGK3 Gene

Orthologs for SGK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SGK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SGK3 34 35
  • 99.8 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 98 (a)
OneToMany
SGK3 34
  • 93.27 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 96 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 95 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SGK3 34 35
  • 94.83 (n)
mouse
(Mus musculus)
Mammalia Sgk3 34 16 35
  • 90.39 (n)
rat
(Rattus norvegicus)
Mammalia Sgk3 34
  • 88.1 (n)
chicken
(Gallus gallus)
Aves SGK3 34 35
  • 84.19 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 92 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia sgk3 34
  • 75.35 (n)
zebrafish
(Danio rerio)
Actinopterygii C24H8orf44 35
  • 79 (a)
OneToMany
sgk3 34
  • 72.22 (n)
worm
(Caenorhabditis elegans)
Secernentea sgk-1 35
  • 44 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPK1 35
  • 28 (a)
ManyToMany
YPK2 35
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9294 35
  • 64 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sck2 34
  • 51.37 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2814 34
Species where no ortholog for SGK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SGK3 Gene

ENSEMBL:
Gene Tree for SGK3 (if available)
TreeFam:
Gene Tree for SGK3 (if available)

Paralogs for SGK3 Gene

Variants for SGK3 Gene

Sequence variations from dbSNP and Humsavar for SGK3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_035636 A breast cancer sample
rs193920898 Uncertain significance 66,840,043(+) TGAGC(A/G)CAGAG reference, missense
rs10095448 -- 66,744,519(+) tatat(A/T)ttttt intron-variant
rs10099769 -- 66,826,223(+) GCCTC(A/G)GCCTC intron-variant
rs10108088 -- 66,740,880(+) ccagc(C/T)tgggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SGK3 Gene

Variant ID Type Subtype PubMed ID
esv2675141 CNV deletion 23128226
esv3543607 CNV deletion 23714750
esv3617491 CNV loss 21293372
nsv1026746 CNV gain 25217958
nsv1117832 CNV deletion 24896259
nsv6238 CNV insertion 18451855
nsv6239 CNV insertion 18451855
nsv831346 CNV loss 17160897
nsv971317 CNV duplication 23825009
esv2466698 CNV insertion 19546169
esv2062022 CNV deletion 18987734
esv1319586 CNV insertion 17803354

Variation tolerance for SGK3 Gene

Residual Variation Intolerance Score: 22.2% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SGK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SGK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SGK3 Gene

Disorders for SGK3 Gene

Relevant External Links for SGK3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SGK3

No disorders were found for SGK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SGK3 Gene

Publications for SGK3 Gene

  1. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. (PMID: 10548550) Kobayashi T. … Cohen P. (Biochem. J. 1999) 2 3 4 22 64
  2. Cloning and mapping of a novel human Serum/Glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1. (PMID: 10585774) Dai F. … Zhao S. (Genomics 1999) 2 3 4 22 64
  3. Identification of Flightless-I as a substrate of the cytokine- independent survival kinase CISK. (PMID: 19293151) Xu J. … Songyang Z. (J. Biol. Chem. 2009) 3 4 22 64
  4. Upregulation of HERG channels by the serum and glucocorticoid inducible kinase isoform SGK3. (PMID: 17167223) Maier G. … Lang F. (Cell. Physiol. Biochem. 2006) 3 4 22 64
  5. Stimulation of the creatine transporter SLC6A8 by the protein kinases SGK1 and SGK3. (PMID: 16036218) Shojaiefard M. … Lang F. (Biochem. Biophys. Res. Commun. 2005) 3 4 22 64

Products for SGK3 Gene

Sources for SGK3 Gene

Content
Loading form....