Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SGK3 Gene

protein-coding   GIFtS: 62
GCID: GC08P067624

Serum/Glucocorticoid Regulated Kinase Family, Member 3

(Previous name: serum/glucocorticoid regulated kinase-like)
(Previous symbols: SGK2, SGKL)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Serum/Glucocorticoid Regulated Kinase Family, Member 31 2     Serum/Glucocorticoid Regulated Kinase-Like1
SGKL1 2 3 5     Serine/Threonine-Protein Kinase Sgk32
CISK2 3 5     Serum/Glucocorticoid-Regulated Kinase 33
SGK21 2     Serum/Glucocorticoid-Regulated Kinase-Like3
Cytokine-Independent Survival Kinase2 3     EC 2.7.118
EC 2.7.11.13 8     

External Ids:    HGNC: 108121   Entrez Gene: 236782   Ensembl: ENSG000001042057   OMIM: 6075915   UniProtKB: Q96BR13   

Export aliases for SGK3 gene to outside databases

Previous GC identifers: GC08P067851 GC08P063176


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SGK3 Gene:
This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology)
domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and
activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different
isoforms, have been characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for SGK3 Gene:
SGK3 (serum/glucocorticoid regulated kinase family, member 3) is a protein-coding gene. An important paralog of this gene is AKT1.

UniProtKB/Swiss-Prot: SGK3_HUMAN, Q96BR1
Function: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels,
membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels:
SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5
and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter:
SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2
and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors:
GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the
regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively
regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of
ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes

Gene Wiki entry for SGK3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008183.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the SGK3 gene promoter:
         GR   NF-1/L   NF-1   GATA-3   Brachyury   GR-beta   GATA-1   GATA-2   GR-alpha   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SGK3 promoter sequence
   Search Chromatin IP Primers for SGK3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SGK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q12   Ensembl cytogenetic band:  8q13.1   HGNC cytogenetic band: 8q12

SGK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SGK3 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P067624:  view genomic region     (about GC identifiers)

Start:
67,624,653 bp from pter      End:
67,774,257 bp from pter
Size:
149,605 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SGK3_HUMAN, Q96BR1 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase Sgk3  
Size: 496 amino acids; 57108 Da
Subunit: Interacts with GSK3B and FLII. Interacts with PDPK1 in a phosphorylation-dependent manner
Sequence caution: Sequence=AAF12758.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K5W3 B3KQC2 Q9P1Q7 Q9UKG5
Alternative splicing: 2 isoforms:  Q96BR1-1   Q96BR1-2   

Explore the universe of human proteins at neXtProt for SGK3: NX_Q96BR1

Explore proteomics data for SGK3 at MOPED

Post-translational modifications: 

  • Activated by phosphorylation on Ser-486 by an unknown kinase (may be mTORC2 but not confirmed), transforming it
    into a substrate for PDPK1 which then phosphorylates it on Thr-3201
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SGK3 (Q96BR1) (see all 12)
     FYAAEIA  VNGGELF  RDLKPEN  DFGLCKE 


    See SGK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001028750.1  NP_037389.4  NP_733827.2  

    ENSEMBL proteins: 
     ENSP00000430463   ENSP00000430475   ENSP00000430256   ENSP00000429606   ENSP00000430691  
     ENSP00000428972   ENSP00000331816   ENSP00000428529   ENSP00000429565   ENSP00000379842  
    Reactome Protein details: Q96BR1

    SGK3 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant SGK3 Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for SGK3
    OriGene Purified Proteins for SGK3
    OriGene Protein Over-expression Lysate for SGK3
    OriGene MassSpec for SGK3
    OriGene Custom Protein Services for SGK3
    GenScript Custom Purified and Recombinant Proteins Services for SGK3
    Novus Biologicals SGK3 Proteins
    Novus Biologicals SGK3 Lysates
    Sino Biological Recombinant Protein for SGK3
    Sino Biological Cell Lysate for SGK3
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SGK3

     
    Search eBioscience for Proteins for SGK3 

    SGK3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for SGK3 
    OriGene Antibodies for SGK3
    OriGene Custom Antibody Services for SGK3
    Novus Biologicals SGK3 Antibodies
    Search for Antibodies for SGK3 at Abcam
    Cloud-Clone Corp. Antibodies for SGK3
    ThermoFisher Antibody for SGK3
    LSBio Antibodies in human, mouse, rat for SGK3

    SGK3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SGK3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SGK3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SGK3
    Cloud-Clone Corp. CLIAs for SGK3
    Search eBioscience for ELISAs for SGK3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: serum/glucocorticoid regulated kinase family, member 3
    SGK family
    Other AGC kinases

    Selected InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR001683 Phox
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C

    Graphical View of Domain Structure for InterPro Entry Q96BR1

    ProtoNet protein and cluster: Q96BR1

    2 Blocks protein domains:
    IPB000961 Protein kinase C-terminal domain
    IPB001683 Phox-like


    UniProtKB/Swiss-Prot: SGK3_HUMAN, Q96BR1
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 PX (phox homology) domain


    Find genes that share domains with SGK3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SGK3_HUMAN, Q96BR1
    Function: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels,
    membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels:
    SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5
    and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter:
    SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2
    and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors:
    GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the
    regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively
    regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of
    ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Two specific sites, one in the kinase domain (Thr-320) and the other in the C-terminal
    regulatory region (Ser-486), need to be phosphorylated for its full activation
    Induction: Induced by estrogen/ER in breast cancer cells

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0005246calcium channel regulator activity ----
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SGK3           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for SGK3:
     Decreased focal adhesion (FA)   Decreased mitotic index  Decreased substrate adherent c  Increased cell death HMECs cel 
     Weaker migration 

         4 MGI mutant phenotypes (inferred from 10 alleles(MGI details for Sgk3):
     growth/size/body  homeostasis/metabolism  immune system  integument 

    Find genes that share phenotypes with SGK3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SGK3: Sgk3tm1Dpea Sgk3tm1Efu

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SGK3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SGK3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SGK3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SGK3

    miRNA
    Products:
        
    miRTarBase miRNAs that target SGK3:
    hsa-mir-16-5p (MIRT031504), hsa-mir-96-5p (MIRT027909), hsa-mir-1 (MIRT023535), hsa-mir-21-5p (MIRT002408)

    Block miRNA regulation of human, mouse, rat SGK3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SGK3 (see all 81):
    hsa-miR-100* hsa-miR-300 hsa-miR-199a-3p hsa-miR-30d hsa-miR-550a* hsa-miR-3916 hsa-miR-3122 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidSGK3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SGK3
    Predesigned siRNA for gene silencing in human, mouse, rat SGK3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SGK3

    Clone
    Products:
         
    OriGene clones in human, mouse for SGK3 (see all 19)
    OriGene ORF clones in mouse, rat for SGK3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SGK3 (NM_013257)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SGK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGK3
    Addgene plasmids for SGK3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SGK3
    Browse ESI BIO Cell Lines and PureStem Progenitors for SGK3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGK3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SGK3_HUMAN, Q96BR1: Cytoplasmic vesicle (By similarity). Early endosome. Recycling endosome. Note=Endosomal
    localization is a prerequisite for complete kinase activity. It is essential for its colocalization with the
    kinase responsible for phosphorylating Ser-486 thus allowing PDPK1 phosphorylation of Thr-320 resulting in
    complete activation of SGK3. Localized in vesicle-like structures and in the early endosome. Colocalizes with
    SLC9A3/NHE3 in the recycling endosomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    cytosol4
    nucleus2
    plasma membrane2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005769early endosome ----
    GO:0005829cytosol ----
    GO:0016023cytoplasmic membrane-bounded vesicle ----
    GO:0055037recycling endosome ----

    Find genes that share ontologies with SGK3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SGK3 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    3Selected targets of ESR1
    Selected targets of ESR1
    4PI3K / Akt Signaling
    PI3K / Akt Signaling
    5PI3K-Akt signaling pathway
    PI3K-Akt signaling pathway


    Find genes that share SuperPaths with SGK3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SGK3
        PI3K / Akt Signaling

    1 BioSystems Pathway for SGK3
        Insulin Signaling


    1 Reactome Pathway for SGK3
        Stimuli-sensing channels


    2 Kegg Pathways  (Kegg details for SGK3):
        FoxO signaling pathway
    PI3K-Akt signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SGK3
    Interactions:

        GeneGlobe Interaction Network for SGK3

    Selected Interacting proteins for SGK3 (Q96BR11, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITCHQ96J021, 2, 3EBI-2801236,EBI-1564678 MINT-2881316 MINT-2881371 MINT-2879884 MINT-2881283 MINT-2881346 I2D: score=1 
    PDK1Q151182, 3MINT-2881442 MINT-2881402 I2D: score=1 
    GSK3BP498413I2D: score=2 
    ESR1P033723I2D: score=1 
    GSK3AP498403I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth ----
    GO:0006468protein phosphorylation ----
    GO:0006950response to stress ----
    GO:0007154cell communication ----
    GO:0030334regulation of cell migration ----

    Find genes that share ontologies with SGK3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for SGK3
      Browse compounds at ApexBio 

    Browse Tocris compounds for SGK3

    2 HMDB Compounds for SGK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    8 Novoseek inferred chemical compound relationships for SGK3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 47.3 4 17167223 (1), 11050396 (1), 16485113 (1), 18464067 (1)
    phosphatidylinositol 45 14 19293151 (3), 10548550 (1), 17015487 (1), 11514587 (1) (see all 5)
    threonine 38.1 1 11050396 (1)
    alanine 28.3 2 17167223 (1), 16485113 (1)
    glutamate 19.9 6 16485113 (2), 12911626 (1), 18464067 (1), 16573659 (1)
    glutamine 16.9 1 12788082 (1)
    glucose 8.8 5 15166308 (2), 17051390 (1)
    lipid 0 2 17356130 (1), 11514587 (1)



    Find genes that share compounds with SGK3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SGK3 gene (3 alternative transcripts): 
    NM_001033578.2  NM_013257.4  NM_170709.2  

    Unigene Cluster for SGK3:

    Serum/glucocorticoid regulated kinase family, member 3
    Hs.613417  [show with all ESTs]
    Unigene Representative Sequence: NM_001204173
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521198 ENST00000523401 ENST00000494528 ENST00000521960 ENST00000522398
    ENST00000522629 ENST00000520976 ENST00000518388 ENST00000345714(uc003xwp.3)
    ENST00000519396 ENST00000521152 ENST00000521435 ENST00000523260 ENST00000396596(uc003xwt.3 uc003xwu.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SGK3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SGK3 (see all 81):
    hsa-miR-100* hsa-miR-300 hsa-miR-199a-3p hsa-miR-30d hsa-miR-550a* hsa-miR-3916 hsa-miR-3122 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidSGK3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SGK3
    Predesigned siRNA for gene silencing in human, mouse, rat SGK3
    Clone
    Products:
         
    OriGene clones in human, mouse for SGK3 (see all 19)
    OriGene ORF clones in mouse, rat for SGK3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SGK3 (NM_013257)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SGK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGK3
    Addgene plasmids for SGK3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SGK3
    OriGene qSTAR qPCR primer pairs in human, mouse for SGK3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SGK3
      QuantiTect SYBR Green Assays in human, mouse, rat SGK3
      QuantiFast Probe-based Assays in human, mouse, rat SGK3

    Additional mRNA sequence: 

    AF169035.1 AK074666.1 AK223523.1 AK291428.1 BC015326.1 CR536581.1 CR933673.1 

    10 DOTS entries:

    DT.101975314  DT.421957  DT.40128432  DT.95157161  DT.95157162  DT.99969225  DT.100683780  DT.91852082 
    DT.95337629  DT.97788047 

    Selected AceView cDNA sequences (see all 139):

    BQ897969 AW770240 AA483276 BU626531 BX107304 AI127772 BQ641920 AV714643 
    CR536581 AI884396 AA211107 CK822899 AW051671 BQ181443 AI439812 BF665552 
    BQ777590 NM_013257 AW517511 AW779720 BQ102291 CD722716 AA423971 NM_170709 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SGK3 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16
    SP1:                                -                                                                                 
    SP2:        -     -                 -                                                                                 
    SP3:                                                                                -                                 
    SP4:                                -                                                                                 
    SP5:              -                 -                                                                                 


    ECgene alternative splicing isoforms for SGK3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SGK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGTCTTGA
    SGK3 Expression
    About this image


    SGK3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Thymus (Hematopoietic System)
             Thymus
    SGK3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SGK3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.613417

    UniProtKB/Swiss-Prot: SGK3_HUMAN, Q96BR1
    Tissue specificity: Expressed in most tissues with highest levels in pancreas, kidney liver, heart and brain and
    lower levels in lung, placenta and skeletal muscle. Expression is higher in ER-positive breast tumors than
    ER-negative breast tumors

        Custom PCR Arrays for SGK3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SGK3
    OriGene qSTAR qPCR primer pairs in human, mouse for SGK3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SGK3
    QuantiTect SYBR Green Assays in human, mouse, rat SGK3
    QuantiFast Probe-based Assays in human, mouse, rat SGK3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGK3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SGK3 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sgk31 , 5 serum/glucocorticoid regulated kinase 31, 5 90.39(n)1
    96.77(a)1
      1 (2.08 cM)5
    1707551  NM_001037759.11  NP_001032848.11 
     97981305 
    chicken
    (Gallus gallus)
    Aves SGK31 serum/glucocorticoid regulated kinase family, member more 84.19(n)
    93.87(a)
      420167  NM_001030940.1  NP_001026111.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    92(a)
    1 → many
    4(30940678-31007924)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sgk31 serum/glucocorticoid regulated kinase family, member more 75.35(n)
    76.81(a)
      100491891  XM_002935321.2  XP_002935367.2 
    zebrafish
    (Danio rerio)
    Actinopterygii sgk31 serum/glucocorticoid regulated kinase family, member more 72.22(n)
    79.01(a)
      564523  NM_001110467.1  NP_001103937.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sgk-16
    Protein SGK-1, isoform a (sgk-1) mRNA, complete cd...
    44(a)
    1 → many
    X(16254840-16262129) WBGene00004789
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YPK26
    YPK16
    Protein kinase with similarity to serine/threonine...
    Serine/threonine protein kinase that phosphorylate...
    28(a)
    28(a)
    many ↔ many
    many ↔ many
    XIII(473420-475453) YMR104C
    XI(205707-207749) YKL126W


    ENSEMBL Gene Tree for SGK3 (if available)
    TreeFam Gene Tree for SGK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SGK3 gene
    C8orf44-SGK31 2  AKT12  GRK72  RPS6KB12  GRK12  GRK42  GRK62  SGK22  
    ADRBK22  AKT32  SGK12  RPS6KB22  GRK52  ADRBK12  AKT22  
    Selected SIMAP similar genes for SGK3 using alignment to 6 protein entries:     SGK3_HUMAN (see all proteins) (see all similar genes):
    DKFZp781N0293    SGKL    SGK2    DMPK    SGK1    PRKACA
    AKT1    MAST4    RPS6KB2    RPS6KA2    CAMK1D    CIT
    PRKY    RPS6KA5    PRKACB    AKT2    RPS6KB1    PKN1

    Find genes that share paralogs with SGK3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    8 SNPs for SGK3    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356364
    A breast cancer sample4--see VAR_0356362 A V mis40--------
    rs1995825721,2
    --67656748(+) TATAT-/AT    
       ATATA
    TTTTT
    1 -- int10--------
    rs352843931,2
    C--67701358(+) AAAAA-/A/AA  
            
    CACTA
    1 -- int12NA 4
    VAR_0410764
    ----see VAR_0410762 L P mis40--------
    rs358646321,2
    ----67623370(+) GTGTT-/GT    
       
    /GTGT
    CTTCA
    1 -- us2k10--------
    rs712475021,2
    ----67635367(+) TATATATATTT/-
            
    TTTTT
    1 -- cds11Minor allele frequency- -:0.00NA 2
    rs712475011,2
    ----67623369(+) TGTGTGT/-TCTTC 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1998877391,2
    ----67699161(+) CTGTC-/TTTTTTT
    TTTTTTTTTT
    TTTTT
    1 -- int10--------

    HapMap Linkage Disequilibrium report for SGK3 (67624653 - 67774257 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SGK3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675141CNV Deletion23128226
    esv2062022CNV Deletion18987734
    nsv6239CNV Insertion18451855
    esv2466698CNV Insertion19546169
    esv1319586CNV Insertion17803354
    nsv6238CNV Insertion18451855
    nsv831346CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SGK3
    DNA2.0 Custom Variant and Variant Library Synthesis for SGK3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607591    OMIM disorders: --


    Find genes that share disorders with SGK3           About GenesLikeMe


    Export disorders for SGK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SGK3 gene, integrated from 10 sources (see all 66):
    (articles sorted by number of sources associating them with SGK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. (PubMed id 10548550)1, 2, 3, 9 Kobayashi T.... Cohen P. (Biochem. J. 1999)
    2. Cloning and mapping of a novel human Serum/Glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1. (PubMed id 10585774)1, 2, 3, 9 Dai F.... Zhao S. (Genomics 1999)
    3. Identification of Flightless-I as a substrate of the cytokine- independent survival kinase CISK. (PubMed id 19293151)1, 2, 9 Xu J.... Songyang Z. (J. Biol. Chem. 2009)
    4. Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms. (PubMed id 12590200)1, 2, 9 Henke G.... Lang F. (Kidney Blood Press. Res. 2002)
    5. Peroxisomal targeting as a tool for assaying protein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner. (PubMed id 14604990)1, 2, 9 Nilsen T....Olsnes S. (J. Biol. Chem. 2004)
    6. Regulation of CLC-Ka/barttin by the ubiquitin ligase Nedd4-2 and the serum- and glucocorticoid-dependent kinases. (PubMed id 15496163)1, 2, 9 Embark H.M....Lang F. (Kidney Int. 2004)
    7. Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms. (PubMed id 12634932)1, 2, 9 Embark H.M.... Lang F. (Pflugers Arch. 2003)
    8. K(+) channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK. (PubMed id 12397388)1, 2, 9 Gamper N.... Lang F. (Pflugers Arch. 2002)
    9. Upregulation of HERG channels by the serum and glucocorticoid inducible kinase isoform SGK3. (PubMed id 17167223)1, 2, 9 Maier G....Lang F. (Cell. Physiol. Biochem. 2006)
    10. Stimulation of the creatine transporter SLC6A8 by the protein kinases SGK1 and SGK3. (PubMed id 16036218)1, 2, 9 Shojaiefard M.... Lang F. (Biochem. Biophys. Res. Commun. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23678 HGNC: 10812 AceView: SGKLandFLJ11267 Ensembl:ENSG00000104205 euGenes: HUgn23678
    ECgene: SGK3 Kegg: 23678 H-InvDB: SGK3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SGK3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SGK3 gene:
    Search GeneIP for patents involving SGK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Purified and/or Recombinant SGK3 Protein
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SGK3   OriGene RNAi products in human, mouse, rat for SGK3  
     OriGene qPCR primer pairs and template standards for SGK3   OriGene Protein Over-expression Lysate for SGK3  
     OriGene MassSpec something-or-other for SGK3   OriGene clones in human, mouse for SGK3  
     OriGene qSTAR qPCR primer pairs in human, mouse for SGK3   OriGene Purified Protein for SGK3  
     OriGene ORF clones in mouse, rat for SGK3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SGK3   OriGene Custom Protein Services for SGK3  

     
     
     Block miRNA regulation of human, mouse, rat SGK3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SGK3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SGK3 Predesigned siRNA for gene silencing in human, mouse, rat SGK3
     QuantiFast Probe-based Assays in human, mouse, rat SGK3 QuantiTect SYBR Green Assays in human, mouse, rat SGK3
     Custom PCR Arrays for SGK3 Search Chromatin IP Primers for SGK3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SGK3  GeneGlobe Interaction Network for SGK3
     Regulatory tfbs in SGK3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SGK3 GenScript cDNA clones with any tag delivered in your preferred vector for SGK3
     GenScript Custom Assay Services for SGK3 GenScript Custom overexpressing Cell Line Services for SGK3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for SGK3 

     Search Tocris compounds for SGK3
     Proteins for SGK3
     Cell Lysates for SGK3
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs/Proteins for SGK3
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SGK3 antibodies
     SGK3 proteins
     SGK3 lysates
     Search for Antibodies for SGK3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SGK3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SGK3
     Antibodies for SGK3
     ELISAs for SGK3
     CLIAs for SGK3



     Browse ESI BIO Cell Lines and PureStem Progenitors for SGK3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGK3
     SwitchGear 3'UTR luciferase reporter plasmids for SGK3
     SwitchGear Promoter luciferase reporter plasmids for SGK3
     ThermoFisher Antibody for SGK3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGK3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SGK3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SGK3
     LSBio Antibodies in human, mouse, rat for SGK3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for SGK3
      Search eBioscience for proteins for SGK3
      Search eBioscience for elisas for SGK3
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SGK3 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4