SGK3 Gene
protein-coding GIFtS: 59
GCID: GC08P067624
|
|
serum/glucocorticoid regulated kinase family, member 3(Previous name: serum/glucocorticoid regulated kinase-like )
(Previous symbols: SGK2, SGKL)
| |
Aliases
for SGK3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Serum/Glucocorticoid Regulated Kinase Family, Member 31 2 | | Serum/Glucocorticoid Regulated Kinase-Like1 | | SGKL1 2 3 5 | | Serine/Threonine-Protein Kinase Sgk32 | | CISK2 3 5 | | Serum/Glucocorticoid-Regulated Kinase 33 | | SGK21 2 | | Serum/Glucocorticoid-Regulated Kinase-Like3 | | Cytokine-Independent Survival Kinase2 3 | | EC 2.7.118 | | EC 2.7.11.13 8 | | |
Export aliases for SGK3 gene to outside databasesPrevious GC identifers: GC08P067851 GC08P063176 |
Summaries
for SGK3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SGK3:
This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology)domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport andactivation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms,have been characterized. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SGK3_HUMAN, Q96BR1Function: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels,membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENACand SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6,chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1,Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamatetransporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6,Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubularphosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activitythrough phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and therebyprevents CXCR4 from being efficiently sorted to lysosomes
Gene Wiki entry for SGK3
|
Genomic Views
for SGK3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008183.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SGK3 gene promoter:
GR NF-1/L NF-1 GATA-3 Brachyury GR-beta GATA-1 GATA-2 GR-alpha FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SGK3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SGK3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q12 Ensembl cytogenetic band: 8q13.1 HGNC cytogenetic band: 8q12SGK3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P067624: view genomic region
(about GC identifiers)
Start:
|
67,579,831 bp from pter |
End:
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67,774,257 bp from pter |
Size:
|
194,427 bases |
Orientation:
|
plus strand |
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Proteins
for SGK3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SGK3_HUMAN, Q96BR1 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase Sgk3 Size: 496 amino acids; 57108 Da
Subunit: Interacts with GSK3B and FLII. Interacts with PDPK1 in a phosphorylation-dependent manner
Subcellular location: Cytoplasmic vesicle (By similarity). Early endosome. Recycling endosome. Note=Endosomallocalization is a prerequisite for complete kinase activity. It is essential for its co-localization with the kinaseresponsible for phosphorylating Ser-486 thus allowing PDPK1 phosphorylation of Thr-320 resulting in completeactivation of SGK3. Localized in vesicle-like structures and in the early endosome. Co-localizes with SLC9A3/NHE3 inthe recycling endosomes
Sequence caution: Sequence=AAF12758.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K5W3 B3KQC2 Q9P1Q7 Q9UKG5Alternative splicing: 2 isoforms: Q96BR1-1 Q96BR1-2 Explore the universe of human proteins at neXtProt for SGK3: NX_Q96BR1
Post-translational modifications:
Activated by phosphorylation on Ser-486 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into asubstrate for PDPK1 which then phosphorylates it on Thr-3201
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96BR1
4/12 DME Specific Peptides for SGK3 (Q96BR1) (see all 12)
SGK3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001028750.1 NP_037389.4 NP_733827.2
ENSEMBL proteins: ENSP00000429022 ENSP00000430463 ENSP00000430475 ENSP00000430256 ENSP00000429606 ENSP00000430691 ENSP00000428972 ENSP00000331816 ENSP00000428529 ENSP00000429565 ENSP00000262211 ENSP00000379842 Reactome Protein details: Q96BR1
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005769 | early endosome |
-- | -- | | GO:0016023 | cytoplasmic membrane-bounded vesicle |
-- | -- | | GO:0055037 | recycling endosome |
-- | -- |
SGK3 for ontologies About GeneDecksing
SGK3 Antibody Products:
Assay Products for SGK3: |
Protein
Domains /
Families
for SGK3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SGK3 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q96BR1ProtoNet protein and cluster: Q96BR1 2 Blocks protein families: IPB000961 Protein kinase C-terminal domain IPB001683 Phox-like
UniProtKB/Swiss-Prot: SGK3_HUMAN, Q96BR1Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase familySimilarity: Contains 1 AGC-kinase C-terminal domainSimilarity: Contains 1 protein kinase domainSimilarity: Contains 1 PX (phox homology) domain |
Function
for SGK3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SGK3_HUMAN, Q96BR1Function: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels,membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENACand SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6,chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1,Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamatetransporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6,Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubularphosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activitythrough phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and therebyprevents CXCR4 from being efficiently sorted to lysosomesCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Two specific sites, one in the kinase domain (Thr-320) and the other in the C-terminal regulatoryregion (Ser-486), need to be phosphorylated for its full activationInduction: Induced by estrogen/ER in breast cancer cellsEnzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SGK3 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SGK3 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector (see all 3): SGK3 (NM_013257) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SGK3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGK3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGK3 |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004672 | protein kinase activity |
-- | -- | | GO:0004674 | protein serine/threonine kinase activity |
-- | -- | | GO:0005246 | calcium channel regulator activity |
-- | -- | | GO:0005524 | ATP binding |
-- | -- | | GO:0015459 | potassium channel regulator activity |
-- | -- |
SGK3 for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for SGK3:
Animal Models:
Mouse knock-outs for SGK3: Sgk3tm1Dpea Sgk3tm1Efu
4 MGI mutant phenotypes (inferred from 10 alleles ) (MGI details for Sgk3):
SGK3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SGK3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ion channel transport | | | 2 | Selected targets of ESR1 | | | 3 | Insulin Signaling | | | 4 | PI3K / Akt Signaling | | | 5 | SLC-mediated transmembrane transport | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for SGK3
1 
Cell Signaling Technology (CST) Pathway for SGK3
1  BioSystems Pathway for SGK3
3 
Reactome Pathways for SGK3
SGK3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SGK3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/8 Interacting proteins for SGK3 (Q96BR12, 3 ENSP000002622114) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
SGK3 for ontologies About GeneDecksing
|
Drugs & Compounds
for SGK3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SGK3 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for SGK3 |
 Browse Tocris compounds for SGK3
2 HMDB Compounds for SGK3 About this table
8 Novoseek chemical compound relationships for SGK3 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| serine |
47.3 |
4 |
17167223 (1), 11050396 (1), 16485113 (1), 18464067 (1) |
| phosphatidylinositol |
45 |
14 |
19293151 (3), 10548550 (1), 17015487 (1), 11514587 (1) (see all 5) |
| threonine |
38.1 |
1 |
11050396 (1) |
| alanine |
28.3 |
2 |
17167223 (1), 16485113 (1) |
| glutamate |
19.9 |
6 |
16485113 (2), 12911626 (1), 18464067 (1), 16573659 (1) |
| glutamine |
16.9 |
1 |
12788082 (1) |
| glucose |
8.8 |
5 |
15166308 (2), 17051390 (1) |
| lipid |
0 |
2 |
17356130 (1), 11514587 (1) |
Search CenterWatch for drugs/clinical trials and news about SGK3
|
Transcripts
for SGK3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SGK3 gene (3 alternative transcripts): NM_001033578.2 NM_013257.4 NM_170709.2 Unigene Cluster for SGK3: Serum/glucocorticoid regulated kinase family, member 3 Hs.613417 [show with all ESTs]Unigene Representative Sequence: NM_00120417317 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000520044 ENST00000519289 ENST00000521198 ENST00000523401 ENST00000494528
ENST00000521960 ENST00000522398 ENST00000522629 ENST00000520976 ENST00000518388
ENST00000345714(uc003xwp.3) ENST00000519396 ENST00000521152 ENST00000521435
ENST00000523260 ENST00000262211(uc003xwr.3) ENST00000396596(uc003xwt.3 uc003xwu.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SGK3 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SGK3 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): SGK3 (NM_013257) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SGK3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGK3 |
Additional cDNA sequence: AF169035.1 AK074666.1 AK223523.1 AK291428.1 BC015326.1 CR536581.1 CR933673.1 10 DOTS entries: DT.101975314 DT.421957 DT.40128432 DT.95157161 DT.95157162 DT.99969225 DT.100683780 DT.91852082 DT.95337629 DT.97788047 24/139 AceView cDNA sequences (see all 139): AW051671 AA211107 AI439812 AF169035 CK822899 AA884846 BX107304 BQ181443 BQ787765 BC015326 AI375182 AK074666 N94726 AW517511 AW779720 AI127772 AA483276 CD722716 BQ102291 BQ086186 AI161430 AU138726 AW770240 BF665552
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SGK3 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SGK3
|
Expression
for SGK3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SGK3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATGTCTTGA
About this image
See SGK3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SGK3
SOURCE GeneReport for Unigene cluster: Hs.613417
UniProtKB/Swiss-Prot: SGK3_HUMAN, Q96BR1Tissue specificity: Expressed in most tissues with highest levels in pancreas, kidney liver, heart and brain and lowerlevels in lung, placenta and skeletal muscle. Expression is higher in ER-positive breast tumors than ER-negativebreast tumors
SABiosciences Custom PCR Arrays for SGK3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SGK3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SGK3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SGK3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SGK3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGK3 |
Orthologs
for SGK3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SGK3 gene from 4/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SGK31 |
serum/glucocorticoid regulated kinase family, member more |
84.19(n)
93.87(a) |
|
420167 NM_001030940.1 NP_001026111.1 |
lizard
(Anolis carolinensis) |
Reptilia |
SGK36 |
-- |
92(a) |
1 ↔ 1 |
4(30980335-31003187) |
zebrafish
(Danio rerio) |
Actinopterygii |
sgk31 |
serum/glucocorticoid regulated kinase family, member more |
72.22(n)
79.01(a) |
|
564523 NM_001110467.1 NP_001103937.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
sgk-16 |
Serine/threonine-protein kinase sgk-1 |
40(a) |
possible ortholog |
X(16254766-16262056) |
ENSEMBL Gene Tree for SGK3 (if available)
TreeFam Gene Tree for SGK3 (if available) |
Paralogs
for SGK3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SGK3 gene
- C8orf44-SGK3 AKT12 RPS6KA62 RPS6KB12 SGK22 RPS6KA12 AKT32 RPS6KA52
- RPS6KA42 SGK12 RPS6KB22 RPS6KA22 AKT22 RPS6KA32
18/57 SIMAP similar genes for SGK3 using alignment to 6 protein entries: SGK3_HUMAN (see all proteins)
(see all similar genes):DKFZp781N0293 SGKL SGK2 SGK1 PRKACA NEK5
AKT1 MAST4 RPS6KA2 RPS6KB2 CAMK1D CIT
PRKY RPS6KA5 AKT2 PRKACB RPS6KB1 PKN1
SGK3 for paralogs About GeneDecksing
|
Genomic Variants
for SGK3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SGK3 (67579831 - 67774257 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SGK3
1 Indel: 100377 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SGK3 |
|
Disorders
/ Diseases
for SGK3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SGK3 for disorders About GeneDecksing
OMIM gene information: 607591
OMIM disorders: --
2  diseases for SGK3: About MalaCardsbreast cancer neuronitis
Export disorders for SGK3 gene to outside databases
|
Publications
for SGK3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SGK3 gene, integrated from 9 sources (see all 61):
(articles sorted by number of sources associating them with SGK3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. (PubMed id 10548550)1, 2, 3, 9 Kobayashi T.... Cohen P. (1999)
- Cloning and mapping of a novel human Serum/Glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1. (PubMed id 10585774)1, 2, 3, 9 Dai F.... Zhao S. (1999)
- Identification of Flightless-I as a Substrate of the Cytokine-independent Survival Kinase CISK. (PubMed id 19293151)1, 2, 9 Xu J....Songyang Z. (2009)
- Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms. (PubMed id 12590200)1, 2, 9 Henke G....Lang F. (2002)
- Peroxisomal targeting as a tool for assaying potein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner. (PubMed id 14604990)1, 2, 9 Nilsen T....Olsnes S. (2004)
- Regulation of CLC-Ka/barttin by the ubiquitin ligase Nedd4-2 and the serum- and glucocorticoid-dependent kinases. (PubMed id 15496163)1, 2, 9 Embark H.M....Lang F. (2004)
- Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms. (PubMed id 12634932)1, 2, 9 Embark H.M....Lang F. (2003)
- K(+) channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK. (PubMed id 12397388)1, 2, 9 Gamper N.... Lang F. (2002)
- Upregulation of HERG channels by the serum and glucocorticoid inducible kinase isoform SGK3. (PubMed id 17167223)1, 2, 9 Maier G....Lang F. (2006)
- Stimulation of the creatine transporter SLC6A8 by the protein kinases SGK1 and SGK3. (PubMed id 16036218)1, 2, 9 Shojaiefard M....Lang F. (2005)
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External Searches for SGK3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing SGK3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing SGK3 gene
(According to HUGE)
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Specialized Databases showing SGK3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for SGK3 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for SGK3 gene:
Search GeneIP for patents involving SGK3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SGK3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SGK3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SGK3 | | | OriGene Protein Over-expression Lysate for SGK3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SGK3 | | OriGene 3'-UTR Clone for SGK3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SGK3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SGK3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SGK3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SGK3 | | OriGene Custom Protein Services for SGK3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SGK3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SGK3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SGK3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SGK3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SGK3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SGK3 |
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| | Antibodies & Assays for SGK3 |
| | | | Search Tocris compounds for SGK3 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGK3 |
|  |  |  | | | | ThermoFisher Antibody for SGK3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGK3 |
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