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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SGK223 Gene

protein-coding   GIFtS: 40
GCID: GC08M008175

Homolog Of Rat Pragma Of Rnd2


  Search for SGK223
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sugen Kinase 2232 3
PRAGMIN2
Homolog Of Rat Pragma Of Rnd22
Tyrosine-Protein Kinase SgK2232
EC 2.7.10.23

External Ids:    Entrez Gene: 1572852   Ensembl: ENSG000001823197   UniProtKB: Q86YV53   

Export aliases for SGK223 gene to outside databases

Previous GC identifer: GC08M007103


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SGK223 Gene: 
SGK223 is a protein-coding gene. GO annotations related to this gene include non-membrane spanning protein tyrosine kinase activity and ATP binding. An important paralog of this gene is PEAK1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_077531.4  NC_018919.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SGK223
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SGK223

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SGK223


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1   Ensembl cytogenetic band:  8p23.1   

SGK223 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SGK223 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M008175:  view genomic region     (about GC identifiers)

Start:
8,175,258 bp from pter      End:
8,244,008 bp from pter
Size:
68,751 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SG223_HUMAN, Q86YV5 (See protein sequence)
Recommended Name: Tyrosine-protein kinase SgK223  
Size: 1402 amino acids; 149311 Da
Secondary accessions: Q8N3N5

Explore the universe of human proteins at neXtProt for SGK223: NX_Q86YV5

Explore proteomics data for SGK223 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86YV5

  • SGK223 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SGK223 Protein Expression
    REFSEQ proteins: NP_001074295.1  
    ENSEMBL proteins: 
     ENSP00000428054   ENSP00000330930  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR008266 Tyr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry Q86YV5

    ProtoNet protein and cluster: Q86YV5

    UniProtKB/Swiss-Prot: SG223_HUMAN, Q86YV5
    Similarity: Belongs to the protein kinase superfamily
    Similarity: Contains 1 protein kinase domain


    SGK223 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SG223_HUMAN, Q86YV5
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Enzyme Number (IUBMB): EC 2.7.10.21

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004715non-membrane spanning protein tyrosine kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    SGK223 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SGK223:
     Decreased focal adhesion (FA)  

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SGK223

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/7 Interacting proteins for SGK223 (Q86YV52, 3 ENSP000003309304) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHGBP050602, 3, ENSP000003682444MINT-64846 I2D: score=4 STRING: ENSP00000368244
    PSAPP076022, 3, ENSP000003783944MINT-64847 I2D: score=4 STRING: ENSP00000378394
    UBE3AQ050862, 3, ENSP000003810454MINT-8276498 I2D: score=2 STRING: ENSP00000381045
    SFNP319472, 3MINT-3976327 I2D: score=1 
    EGFRP005333I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    SGK223 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SGK223 (SG223)

    Search CenterWatch for drugs/clinical trials and news about SGK223 / SG223

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SGK223 gene: 
    NM_001080826.1  

    Unigene Cluster for SGK223:

    Homolog of rat pragma of Rnd2
    Hs.657673  [show with all ESTs]
    Unigene Representative Sequence: NM_001080826
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000520004 ENST00000330777(uc003wsh.4)
    miRNA
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    Inhib. RNA
    Products:
         
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    Additional mRNA sequence: 

    AF075060.1 AK122582.1 AL833872.1 

    1 DOTS entry:

    DT.310428 

    24/35 AceView cDNA sequences (see all 35):

    AI918219 AI393927 BX106109 R70141 BF820929 BM145650 BF436003 AI392901 
    BF525647 BQ688679 BU753714 AA687243 AI283647 AI151293 BX420505 BG754185 
    AL833872 AF075060 AK122582 BF739767 AA148983 BU160727 AW295170 BQ220319 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SGK223 expression in normal human tissues (normalized intensities)      SGK223 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAACGTCCTG
    SGK223 Expression
    About this image


    SGK223 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Eye (Sensory Organs)
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium

    See SGK223 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SGK223

    SOURCE GeneReport for Unigene cluster: Hs.657673
        SABiosciences Custom PCR Arrays for SGK223
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGK223

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SGK223 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia D8Ertd82e1 , 5 DNA segment, Chr 8, ERATO Doi 82, expressed1, 5 80.72(n)1
    79.18(a)1
      8 (22.78 cM)5
    2444181  NM_172911.31  NP_766499.21 
     360948285 
    chicken
    (Gallus gallus)
    Aves SGK2231 homolog of rat pragma of Rnd2 61.48(n)
    56.03(a)
      422632  XM_420588.3  XP_420588.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    47(a)
    1 ↔ 1
    GL343257.1(791014-870797)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985522 hypothetical protein LOC398552 75.47(n)    BC046743.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01072929.16
    Uncharacterized protein
    57(a)
    1 ↔ 1
    21(754536-756300)


    ENSEMBL Gene Tree for SGK223 (if available)
    TreeFam Gene Tree for SGK223 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SGK223 gene
    PEAK12  

    SGK223 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1874 SNPs in SGK223 are shown (see all 1874)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0418064
    ----see VAR_0418062 R Q mis40--------
    VAR_0418144
    ----see VAR_0418142 V M mis40--------
    VAR_0418094
    ----see VAR_0418092 P A mis40--------
    VAR_0418154
    ----see VAR_0418152 A T mis40--------
    VAR_0418074
    ----see VAR_0418072 P L mis40--------
    VAR_0418164
    ----see VAR_0418162 R H mis40--------
    VAR_0418084
    ----see VAR_0418082 S C mis40--------
    VAR_0418124
    ----see VAR_0418122 H R mis40--------
    VAR_0418114
    ----see VAR_0418112 P L mis40--------
    VAR_0418034
    ----see VAR_0418032 L I mis40--------

    HapMap Linkage Disequilibrium report for SGK223 (8175258 - 8244008 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SGK223:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv274588CNV Insertion20981092
    esv267582CNV Insertion20981092
    esv33394CNV Loss17666407
    nsv396756CNV Loss16902084
    nsv890331CNV Loss21882294
    nsv831227CNV Gain+Loss17160897
    essv21038CNV CNV17122850
    dgv2191e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SGK223 for disorders           About MalaCards

    SGK223 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SGK223
    Human Genome Epidemiology (HuGE) Navigator: SGK223 (0 documents)

    Export disorders for SGK223 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SGK223 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with SGK223)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The protein kinase complement of the human genome. (PubMed id 12471243)1, 2 Manning G.... Sudarsanam S. (2002)
    2. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    3. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    4. Mammalian Pragmin regulates Src family kinases via th e Glu-Pro-Ile-Tyr-Ala (EPIYA) motif that is exploited by bacterial effectors. (PubMed id 21873224)1 Safari F....Hatakeyama M. (2011)
    5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    8. The SH3 domain of postsynaptic density 95 mediates inf lammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (2010)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 157285 AceView: DKFZp761P0423 Ensembl:ENSG00000182319 euGenes: HUgn157285

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SGK223 gene:
    Search GeneIP for patents involving SGK223

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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