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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SGK223 Gene

protein-coding   GIFtS: 36
GCID: GC08M008175

SGK223
  Search for SGK223
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SGK223    

Aliases
for SGK223 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sugen Kinase 2232 3
PRAGMIN2
Homolog Of Rat Pragma Of Rnd22
Tyrosine-Protein Kinase SgK2232
EC 2.7.10.23

External Ids:    Entrez Gene: 1572852   Ensembl: ENSG000001823197   UniProtKB: Q86YV53   

Export aliases for SGK223 gene to outside databases

Previous GC identifer: GC08M007103


Summaries
for SGK223 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for SGK223 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_077531.4  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SGK223
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SGK223

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SGK223


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1   Ensembl cytogenetic band:  8p23.1   

SGK223 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SGK223 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M008175:  view genomic region     (about GC identifiers)

Start:
 8,175,258 bp from pter      End:
 8,244,008 bp from pter
Size:
 68,751 bases      Orientation:
 minus strand

Proteins
for SGK223 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SG223_HUMAN, Q86YV5 (See protein sequence)
Recommended Name: Tyrosine-protein kinase SgK223  
Size: 1402 amino acids; 149311 Da
Secondary accessions: Q8N3N5

Explore the universe of human proteins at neXtProt for SGK223: NX_Q86YV5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86YV5

    • SGK223 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001074295.1  
    ENSEMBL proteins: 
     ENSP00000428054   ENSP00000330930  

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    Protein Domains /
    Families
    for SGK223 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SGK223 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR008266 Tyr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry Q86YV5

    ProtoNet protein and cluster: Q86YV5

    UniProtKB/Swiss-Prot: SG223_HUMAN, Q86YV5
    Similarity: Belongs to the protein kinase superfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for SGK223 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SG223_HUMAN, Q86YV5
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

    Enzyme Number (IUBMB): EC 2.7.10.21

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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004715non-membrane spanning protein tyrosine kinase activity IEA--
    GO:0005524ATP binding IEA--


    SGK223 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SGK223:
     Decreased focal adhesion (FA)  


    Pathways & Interactions
    for SGK223 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SGK223

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/7 Interacting proteins for SGK223 (Q86YV52, 3 ENSP000003309304) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHGBP050602, 3, ENSP000003682444MINT-64846 I2D: score=4 STRING: ENSP00000368244
    PSAPP076022, 3, ENSP000003783944MINT-64847 I2D: score=4 STRING: ENSP00000378394
    UBE3AQ050862, 3, ENSP000003810454MINT-8276498 I2D: score=2 STRING: ENSP00000381045
    SFNP319472, 3MINT-3976327 I2D: score=1 
    EGFRP005333I2D: score=1 
    About this table

    Drugs & Compounds
    for SGK223 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SGK223
    Search CenterWatch for drugs/clinical trials and news about SGK223 / SG223 

    Transcripts
    for SGK223 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for SGK223 gene: 
    NM_001080826.1  

    Unigene Cluster for SGK223:

    Homolog of rat pragma of Rnd2
    Hs.657673  [show with all ESTs]
    Unigene Representative Sequence: NM_001080826
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000520004 ENST00000330777(uc003wsh.4)

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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF075060.1 AK122582.1 AL833872.1 

    1 DOTS entry:

    DT.310428 

    24/35 AceView cDNA sequences (see all 35):

    R70141 AI393927 BX106109 AI918219 AI392901 AK122582 AF075060 BF436003 
    BG754185 BF820929 AI151293 AA148983 BQ688679 AA687243 BF525647 BU160727 
    BX420505 BM145650 AL833872 BU753714 AI283647 BF739767 AI783873 AW295170 

    GeneLoc Exon Structure


    Expression
    for SGK223 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SGK223 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAACGTCCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SGK223 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SGK223 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SGK223

    SOURCE GeneReport for Unigene cluster: Hs.657673
        SABiosciences Custom PCR Arrays for SGK223
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGK223

    Orthologs
    for SGK223 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for SGK223 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SGK2231 homolog of rat pragma of Rnd2 61.48(n)
    56.03(a)    		   422632  XM_420588.3  XP_420588.3 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 68(a)
    43(a)
    		 1 ↔ 1
    possible ortholog
    		 GL343257.1(794128-801516)
    GL343257.1(848612-849030)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3985522 hypothetical protein LOC398552 75.47(n)    BC046743.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii CABZ01072929.16
    		 --
    		 58(a)
    		 1 ↔ 1
    		 21(754536-756300)


    ENSEMBL Gene Tree for SGK223 (if available)
    TreeFam Gene Tree for SGK223 (if available) 

    Paralogs
    for SGK223 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SGK223 gene
    PEAK12  C19orf352  

    SGK223 for paralogs           About GeneDecksing



    Genomic Variants
    for SGK223 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1499 NCBI SNPs in SGK223 are shown (see all 1499)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1504896291,2
    		--8174832(+) CTCAGA/CGCGAA 1 -- ds50010--------
    rs1907313291,2
    		--8174843(+) TACCTC/GCTGTA 1 -- ds50010--------
    rs1833935761,2
    		--8174884(+) CTTTTC/GGCCTT 1 -- ds50010--------
    rs14013891,2
    		C,F,A,H,--8174921(-) GCTAGG/CTGTGA 1 -- ds500116Minor allele frequency- C:0.49NS NA WA CSA EA 588
    rs562195251,2
    		C,F,--8174985(+) TTCAGG/ACACGT 1 -- ds50011Minor allele frequency- A:0.03NA 120
    rs13566271,2
    		C,F,A,--8174989(-) AGAGAC/TGTGCC 1 -- ds500110Minor allele frequency- T:0.17NS WA CSA NA 454
    rs1383031291,2
    		--8174996(+) CTCTGA/CATTTT 1 -- ds50010--------
    rs558526931,2
    		C,F,--8175136(+) TACCCA/CCTTGC 1 -- ds50015Minor allele frequency- C:0.20WA CSA NA 244
    rs1496177211,2
    		--8175165(+) CTGCTC/GTATCT 1 -- ds50010--------
    rs1488542551,2
    		C,--8175270(+) CAACC-/AAAAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SGK223 (8175258 - 8244008 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SGK223: --

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    Disorders / Diseases
    for SGK223 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SGK223 for disorders           About MalaCards

    SGK223 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: SGK223 (0 documents)

    Export disorders for SGK223 gene to outside databases

    Publications
    for SGK223 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SGK223 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with SGK223)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The protein kinase complement of the human genome. (PubMed id 12471243)1, 2 Manning G.... Sudarsanam S. (2002)
    2. Mammalian Pragmin regulates Src family kinases via th e Glu-Pro-Ile-Tyr-Ala (EPIYA) motif that is exploited by bacterial effectors. (PubMed id 21873224)1 Safari F....Hatakeyama M. (2011)
    3. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    4. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    5. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    9. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)

    External Searches for SGK223 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SGK223 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 157285 AceView: DKFZp761P0423 Ensembl:ENSG00000182319 euGenes: HUgn157285

    Other Databases showing SGK223 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SGK223 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    		   --

    Intellectual Property
    for SGK223 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SGK223 gene:
    Search GeneIP for patents involving SGK223

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SGK223 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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    About This Section

     
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