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Aliases for SGK223 Gene

Aliases for SGK223 Gene

  • Homolog Of Rat Pragma Of Rnd2 3
  • Tyrosine-Protein Kinase SgK223 3 5
  • Sugen Kinase 223 3 4
  • EC 2.7.10.2 4
  • PRAGMIN 3

External Ids for SGK223 Gene

Previous GeneCards Identifiers for SGK223 Gene

  • GC08M008175
  • GC08M007103

Summaries for SGK223 Gene

Entrez Gene Summary for SGK223 Gene

  • This gene encodes an enzyme that belongs to the tyrosine protein kinase family. A similar protein in rat binds to Rho family GTPase 2 (Rnd2) and regulates neurite outgrowth via activation of Ras homolog gene family, member A (RhoA). [provided by RefSeq, Mar 2014]

GeneCards Summary for SGK223 Gene

SGK223 (Homolog Of Rat Pragma Of Rnd2) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and non-membrane spanning protein tyrosine kinase activity. An important paralog of this gene is PEAK1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGK223 Gene

Genomics for SGK223 Gene

Regulatory Elements for SGK223 Gene

Enhancers for SGK223 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SGK223 on UCSC Golden Path with GeneCards custom track

Promoters for SGK223 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SGK223 on UCSC Golden Path with GeneCards custom track

Genomic Location for SGK223 Gene

Chromosome:
8
Start:
8,317,736 bp from pter
End:
8,386,498 bp from pter
Size:
68,763 bases
Orientation:
Minus strand

Genomic View for SGK223 Gene

Genes around SGK223 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGK223 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGK223 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGK223 Gene

Proteins for SGK223 Gene

  • Protein details for SGK223 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YV5-SG223_HUMAN
    Recommended name:
    Tyrosine-protein kinase SgK223
    Protein Accession:
    Q86YV5
    Secondary Accessions:
    • Q8N3N5

    Protein attributes for SGK223 Gene

    Size:
    1406 amino acids
    Molecular mass:
    149624 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SGK223 Gene

Post-translational modifications for SGK223 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SGK223 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SGK223 Gene

Domains & Families for SGK223 Gene

Protein Domains for SGK223 Gene

Suggested Antigen Peptide Sequences for SGK223 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86YV5

UniProtKB/Swiss-Prot:

SG223_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily.
genes like me logo Genes that share domains with SGK223: view

No data available for Gene Families for SGK223 Gene

Function for SGK223 Gene

Molecular function for SGK223 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Enzyme Numbers (IUBMB) for SGK223 Gene

Gene Ontology (GO) - Molecular Function for SGK223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IBA --
GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with SGK223: view
genes like me logo Genes that share phenotypes with SGK223: view

Animal Models for SGK223 Gene

MGI Knock Outs for SGK223:

Animal Model Products

CRISPR Products

miRNA for SGK223 Gene

miRTarBase miRNAs that target SGK223

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SGK223 Gene

Localization for SGK223 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SGK223 Gene

Pathways & Interactions for SGK223 Gene

SuperPathways for SGK223 Gene

No Data Available

Interacting Proteins for SGK223 Gene

Gene Ontology (GO) - Biological Process for SGK223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
genes like me logo Genes that share ontologies with SGK223: view

No data available for Pathways by source and SIGNOR curated interactions for SGK223 Gene

Drugs & Compounds for SGK223 Gene

No Compound Related Data Available

Transcripts for SGK223 Gene

mRNA/cDNA for SGK223 Gene

Unigene Clusters for SGK223 Gene

Homolog of rat pragma of Rnd2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SGK223 Gene

No ASD Table

Relevant External Links for SGK223 Gene

GeneLoc Exon Structure for
SGK223

Expression for SGK223 Gene

mRNA expression in normal human tissues for SGK223 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SGK223 Gene

This gene is overexpressed in Brain - Cerebellum (x5.9) and Brain - Cerebellar Hemisphere (x5.5).

Protein differential expression in normal tissues from HIPED for SGK223 Gene

This gene is overexpressed in Lung (21.5), Peripheral blood mononuclear cells (19.9), and Neutrophil (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SGK223 Gene



Protein tissue co-expression partners for SGK223 Gene

SOURCE GeneReport for Unigene cluster for SGK223 Gene:

Hs.657673
genes like me logo Genes that share expression patterns with SGK223: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SGK223 Gene

Orthologs for SGK223 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SGK223 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC533821 34
  • 83.35 (n)
  • 81.26 (a)
dog
(Canis familiaris)
Mammalia LOC482885 34
  • 84.14 (n)
  • 82.57 (a)
mouse
(Mus musculus)
Mammalia D8Ertd82e 34
  • 80.07 (n)
  • 77.89 (a)
D8Ertd82e 16
chimpanzee
(Pan troglodytes)
Mammalia LOC472692 34
  • 99.18 (n)
  • 98.7 (a)
rat
(Rattus norvegicus)
Mammalia Pragmin 34
  • 79.35 (n)
  • 77.49 (a)
chicken
(Gallus gallus)
Aves SGK223 34
  • 60.55 (n)
  • 55.02 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486686 34
  • 55.67 (n)
  • 54.73 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398552 34
Species where no ortholog for SGK223 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SGK223 Gene

ENSEMBL:
Gene Tree for SGK223 (if available)
TreeFam:
Gene Tree for SGK223 (if available)

Paralogs for SGK223 Gene

Paralogs for SGK223 Gene

genes like me logo Genes that share paralogs with SGK223: view

Variants for SGK223 Gene

Sequence variations from dbSNP and Humsavar for SGK223 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs55764617 - 8,378,045(+) CGGGA(G/T)GGGGA reference, missense
rs56290960 - 8,378,000(+) ACCTC(A/C/G)GAAGC reference, missense
rs34346032 - 8,377,994(+) CTGTA(C/T)ACCTC reference, missense
rs3896980 - 8,377,198(-) CCCCC(A/G/T)GGAGG reference, missense
rs4840955 - 8,376,703(+) CCAGC(A/G)GTGAC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SGK223 Gene

Variant ID Type Subtype PubMed ID
esv2759589 CNV gain+loss 17122850
esv2764098 CNV gain+loss 21179565
esv3303302 CNV mobile element insertion 20981092
esv3310316 CNV mobile element insertion 20981092
esv33394 CNV loss 17666407
esv3616132 CNV loss 21293372
nsv396756 CNV deletion 16902084
nsv478031 CNV novel sequence insertion 20440878
nsv610152 CNV gain 21841781
nsv610153 CNV loss 21841781
nsv610154 CNV loss 21841781
nsv610156 CNV loss 21841781
nsv610157 CNV loss 21841781
nsv831227 CNV gain+loss 17160897

Variation tolerance for SGK223 Gene

Residual Variation Intolerance Score: 96.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 25.84; 99.74% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SGK223 Gene

Disorders for SGK223 Gene

Relevant External Links for SGK223

Genetic Association Database (GAD)
SGK223
Human Genome Epidemiology (HuGE) Navigator
SGK223

No disorders were found for SGK223 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SGK223 Gene

Publications for SGK223 Gene

  1. The protein kinase complement of the human genome. (PMID: 12471243) Manning G. … Sudarsanam S. (Science 2002) 3 4 65
  2. The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling. (PMID: 26215634) Tactacan C.M. … Daly R.J. (Mol. Cancer 2015) 3 65
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 65
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 65
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 65

Products for SGK223 Gene

Sources for SGK223 Gene

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