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SGK223 Gene

protein-coding   GIFtS: 43
GCID: GC08M008175

Homolog Of Rat Pragma Of Rnd2


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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sugen Kinase 2232 3
PRAGMIN2
Homolog Of Rat Pragma Of Rnd22
Tyrosine-Protein Kinase SgK2232
EC 2.7.10.23

External Ids:    Entrez Gene: 1572852   Ensembl: ENSG000001823197   UniProtKB: Q86YV53   

Export aliases for SGK223 gene to outside databases

Previous GC identifer: GC08M007103


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SGK223 Gene:
This gene encodes an enzyme that belongs to the tyrosine protein kinase family. A similar protein in rat binds to
Rho family GTPase 2 (Rnd2) and regulates neurite outgrowth via activation of Ras homolog gene family, member A
(RhoA). (provided by RefSeq, Mar 2014)

GeneCards Summary for SGK223 Gene:
SGK223 is a protein-coding gene. GO annotations related to this gene include non-membrane spanning protein tyrosine kinase activity. An important paralog of this gene is PEAK1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_077531.5  NC_018919.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SGK223
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SGK223

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SGK223


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1   Ensembl cytogenetic band:  8p23.1   

SGK223 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SGK223 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M008175:  view genomic region     (about GC identifiers)

Start:
8,175,258 bp from pter      End:
8,244,008 bp from pter
Size:
68,751 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SG223_HUMAN, Q86YV5 (See protein sequence)
Recommended Name: Tyrosine-protein kinase SgK223  
Size: 1402 amino acids; 149311 Da
Secondary accessions: Q8N3N5

Explore the universe of human proteins at neXtProt for SGK223: NX_Q86YV5

Explore proteomics data for SGK223 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SGK223 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001074295.2  
    ENSEMBL proteins: 
     ENSP00000428054   ENSP00000330930  

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    antibodies-online proteins for SGK223 (2 products) 

     
    antibodies-online peptides for SGK223

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR008266 Tyr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry Q86YV5

    ProtoNet protein and cluster: Q86YV5

    UniProtKB/Swiss-Prot: SG223_HUMAN, Q86YV5
    Similarity: Belongs to the protein kinase superfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with SGK223           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SG223_HUMAN, Q86YV5
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Enzyme Number (IUBMB): EC 2.7.10.21

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004715non-membrane spanning protein tyrosine kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    Find genes that share ontologies with SGK223           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SGK223:
     Decreased focal adhesion (FA)  

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SGK223

    miRNA
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    miRTarBase miRNAs that target SGK223:
    hsa-mir-335-5p (MIRT018036)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SGK223
    Interactions:

        Search GeneGlobe Interaction Network for SGK223

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for SGK223 (Q86YV52, 3 ENSP000003309304) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHGBP050602, 3, ENSP000003682444MINT-64846 I2D: score=4 STRING: ENSP00000368244
    PSAPP076022, 3, ENSP000003783944MINT-64847 I2D: score=4 STRING: ENSP00000378394
    UBE3AQ050862, 3, ENSP000003810454MINT-8276498 I2D: score=2 STRING: ENSP00000381045
    SFNP319472, 3MINT-3976327 I2D: score=1 
    EGFRP005333I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    Find genes that share ontologies with SGK223           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SGK223 (SG223)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SGK223 gene: 
    NM_001080826.2  

    Unigene Cluster for SGK223:

    Homolog of rat pragma of Rnd2
    Hs.657673  [show with all ESTs]
    Unigene Representative Sequence: NM_001080826
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000520004 ENST00000330777(uc003wsh.4)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat SGK223

    Additional mRNA sequence: 

    AF075060.1 AK122582.1 AL833872.1 

    1 DOTS entry:

    DT.310428 

    Selected AceView cDNA sequences (see all 35):

    R70141 BX106109 AI393927 AI918219 AI283647 BF739767 AI392901 BU160727 
    AI151293 BF436003 BF525647 BG754185 BQ688679 BF820929 BU753714 BX420505 
    AA148983 BM145650 AL833872 AK122582 AF075060 AA687243 AW295170 BE242203 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SGK223 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAACGTCCTG
    SGK223 Expression
    About this image


    SGK223 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Epithelial Cells
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Eye (Sensory Organs)
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    SGK223 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SGK223 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.657673
        Custom PCR Arrays for SGK223
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGK223

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SGK223 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia D8Ertd82e1 , 5 DNA segment, Chr 8, ERATO Doi 82, expressed1, 5 80.07(n)1
    77.89(a)1
      8 (22.78 cM)5
    2444181  NM_172911.31  NP_766499.21 
     360948285 
    chicken
    (Gallus gallus)
    Aves SGK2231 homolog of rat pragma of Rnd2 60.55(n)
    55.02(a)
      422632  XM_420588.4  XP_420588.4 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    46(a)
    1 ↔ 1
    GL343257.1(791014-870797)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985522 hypothetical protein LOC398552 75.47(n)    BC046743.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01072929.16
    Uncharacterized protein
    58(a)
    1 ↔ 1
    21(754536-756300) ENSDARG00000088305


    ENSEMBL Gene Tree for SGK223 (if available)
    TreeFam Gene Tree for SGK223 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SGK223 gene
    PEAK12  

    Find genes that share paralogs with SGK223           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SGK223 (see all 1874)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105830761,2
    C--7114363(+) ttttt-/T/TTT 
            
    gatga
    1 -- int11NA 2
    rs610519161,2
    C--7114365(+) TTTTT-/TGATGAA 1 -- int10--------
    rs1504896291,2
    C--8174832(+) CTCAGA/CGCGAA 1 -- ds50010--------
    rs1907313291,2
    --8174843(+) TACCTC/GCTGTA 1 -- ds50010--------
    rs1833935761,2
    --8174884(+) CTTTTC/GGCCTT 1 -- ds50010--------
    rs14013891,2
    C,F,A,H--8174921(-) GCTAGG/CTGTGA 1 -- ds500116Minor allele frequency- C:0.49NS NA WA CSA EA 588
    rs562195251,2
    C,F--8174985(+) TTCAGG/ACACGT 1 -- ds50011Minor allele frequency- A:0.03NA 120
    rs13566271,2
    C,F,A--8174989(-) AGAGAC/TGTGCC 1 -- ds500110Minor allele frequency- T:0.17NS WA CSA NA 454
    rs1383031291,2
    --8174996(+) CTCTGA/CATTTT 1 -- ds50010--------
    rs558526931,2
    C,F--8175136(+) TACCCA/CCTTGC 1 -- ds50015Minor allele frequency- C:0.20WA CSA NA 244

    HapMap Linkage Disequilibrium report for SGK223 (8175258 - 8244008 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SGK223:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv274588CNV Insertion20981092
    esv267582CNV Insertion20981092
    esv33394CNV Loss17666407
    nsv396756CNV Loss16902084
    nsv890331CNV Loss21882294
    nsv831227CNV Gain+Loss17160897
    essv21038CNV CNV17122850
    dgv2191e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): SGK223
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SGK223
    DNA2.0 Custom Variant and Variant Library Synthesis for SGK223

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with SGK223           About GenesLikeMe

    Genetic Association Database (GAD): SGK223
    Human Genome Epidemiology (HuGE) Navigator: SGK223 (0 documents)

    Export disorders for SGK223 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SGK223 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with SGK223)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The protein kinase complement of the human genome. (PubMed id 12471243)1, 2 Manning G.... Sudarsanam S. (Science 2002)
    2. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    3. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    4. Mammalian Pragmin regulates Src family kinases via the Glu-Pro-Ile-Tyr-Ala (EPIYA) motif that is exploited by bacterial effectors. (PubMed id 21873224)1 Safari F....Hatakeyama M. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
    9. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)1 Choudhary C.... Mann M. (Science 2009)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 157285 AceView: DKFZp761P0423 Ensembl:ENSG00000182319 euGenes: HUgn157285

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SGK223 gene:
    Search GeneIP for patents involving SGK223

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     OriGene Antibodies for SGK223   OriGene RNAi products in human, mouse, rat for SGK223  
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     Block miRNA regulation of human, mouse, rat SGK223 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SGK223
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     Custom PCR Arrays for SGK223 Search Chromatin IP Primers for SGK223
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     Search Tocris compounds for SGK223 (SG223)
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     Browse ESI BIO Cell Lines and PureStem Progenitors for SGK223
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     Browse compounds at ApexBio
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      Search eBioscience for proteins for SGK223
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      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for SGK223
     antibodies-online antibodies for SGK223 (27 products)
     antibodies-online kits for SGK223 (2 products)
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     antibodies-online proteins for SGK223 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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