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Aliases for SGK2 Gene

Aliases for SGK2 Gene

  • SGK2, Serine/Threonine Kinase 2 2
  • Serum/Glucocorticoid Regulated Kinase 2 2 3 5
  • EC 2.7.11.1 4 63
  • Serum/Glucocorticoid-Regulated Kinase 2 4
  • DJ138B7.2 3
  • EC 2.7.11 63
  • H-SGK2 3

External Ids for SGK2 Gene

Previous GeneCards Identifiers for SGK2 Gene

  • GC20P041916
  • GC20P042826
  • GC20P042873
  • GC20P041621
  • GC20P042187
  • GC20P038923

Summaries for SGK2 Gene

Entrez Gene Summary for SGK2 Gene

  • This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

GeneCards Summary for SGK2 Gene

SGK2 (SGK2, Serine/Threonine Kinase 2) is a Protein Coding gene. Among its related pathways are Ion channel transport and PI3K-Akt signaling pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AKT1.

UniProtKB/Swiss-Prot for SGK2 Gene

  • Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase.

Gene Wiki entry for SGK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGK2 Gene

Genomics for SGK2 Gene

Regulatory Elements for SGK2 Gene

Enhancers for SGK2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SGK2 on UCSC Golden Path with GeneCards custom track

Promoters for SGK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SGK2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SGK2 Gene

Chromosome:
20
Start:
43,558,968 bp from pter
End:
43,588,237 bp from pter
Size:
29,270 bases
Orientation:
Plus strand

Genomic View for SGK2 Gene

Genes around SGK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGK2 Gene

Proteins for SGK2 Gene

  • Protein details for SGK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBY8-SGK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase Sgk2
    Protein Accession:
    Q9HBY8
    Secondary Accessions:
    • Q52PK5
    • Q5H8Y6
    • Q5H8Z1
    • Q5TZR3
    • Q9UKG6

    Protein attributes for SGK2 Gene

    Size:
    427 amino acids
    Molecular mass:
    47604 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SGK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SGK2 Gene

Proteomics data for SGK2 Gene at MOPED

Post-translational modifications for SGK2 Gene

  • Activated by phosphorylation on Ser-416 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-253.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SGK2 (SGK2)

Domains & Families for SGK2 Gene

Suggested Antigen Peptide Sequences for SGK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HBY8

UniProtKB/Swiss-Prot:

SGK2_HUMAN :
  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with SGK2: view

Function for SGK2 Gene

Molecular function for SGK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Two specific sites, one in the kinase domain (Thr-253) and the other in the C-terminal regulatory region (Ser-416), need to be phosphorylated for its full activation.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase.

Enzyme Numbers (IUBMB) for SGK2 Gene

Gene Ontology (GO) - Molecular Function for SGK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with SGK2: view
genes like me logo Genes that share phenotypes with SGK2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SGK2

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SGK2 Gene

Localization for SGK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SGK2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SGK2 Gene COMPARTMENTS Subcellular localization image for SGK2 gene
Compartment Confidence
cytosol 5
nucleus 4
extracellular 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for SGK2 Gene

Pathways & Interactions for SGK2 Gene

genes like me logo Genes that share pathways with SGK2: view

Pathways by source for SGK2 Gene

1 Cell Signaling Technology pathway for SGK2 Gene
1 BioSystems pathway for SGK2 Gene

SIGNOR curated interactions for SGK2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SGK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,NAS 12397388
GO:0010765 positive regulation of sodium ion transport IBA --
GO:0034220 ion transmembrane transport TAS --
genes like me logo Genes that share ontologies with SGK2: view

Drugs & Compounds for SGK2 Gene

(2) Drugs for SGK2 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
GSK 650394 Pharma SGK1 inhibitor 0

(1) Additional Compounds for SGK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(1) ApexBio Compounds for SGK2 Gene

Compound Action Cas Number
GSK 650394 SGK1 inhibitor 890842-28-1
genes like me logo Genes that share compounds with SGK2: view

Transcripts for SGK2 Gene

Unigene Clusters for SGK2 Gene

Serum/glucocorticoid regulated kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SGK2 Gene

No ASD Table

Relevant External Links for SGK2 Gene

GeneLoc Exon Structure for
SGK2
ECgene alternative splicing isoforms for
SGK2

Expression for SGK2 Gene

mRNA expression in normal human tissues for SGK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SGK2 Gene

This gene is overexpressed in Liver (x11.4), Kidney - Cortex (x8.1), and Colon - Transverse (x5.5).

Protein differential expression in normal tissues from HIPED for SGK2 Gene

This gene is overexpressed in Nasal epithelium (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SGK2 Gene



SOURCE GeneReport for Unigene cluster for SGK2 Gene Hs.300863

mRNA Expression by UniProt/SwissProt for SGK2 Gene

Q9HBY8-SGK2_HUMAN
Tissue specificity: Highly expressed in liver, kidney and pancreas, and at lower levels in brain.
genes like me logo Genes that share expression patterns with SGK2: view

Protein tissue co-expression partners for SGK2 Gene

Primer Products

Orthologs for SGK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SGK2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SGK2 35
  • 90.92 (n)
  • 95.91 (a)
SGK2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SGK2 35
  • 90.9 (n)
  • 92.86 (a)
mouse
(Mus musculus)
Mammalia Sgk2 35
  • 89.16 (n)
  • 94.26 (a)
Sgk2 16
Sgk2 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SGK2 35
  • 99.27 (n)
  • 99.18 (a)
SGK2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sgk2 35
  • 88.16 (n)
  • 93.72 (a)
oppossum
(Monodelphis domestica)
Mammalia SGK2 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SGK2 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves SGK2 35
  • 76.92 (n)
  • 82.97 (a)
SGK2 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SGK2 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sgk2 35
  • 74.4 (n)
  • 82.81 (a)
Str.5294 35
zebrafish
(Danio rerio)
Actinopterygii sgk2a 35
  • 68.83 (n)
  • 74.93 (a)
sgk2a 36
  • 74 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9898 35
worm
(Caenorhabditis elegans)
Secernentea W10G6.2 37
  • 54 (a)
sgk-1 36
  • 39 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL028W 35
  • 54.93 (n)
  • 54.4 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B12716g 35
  • 53.4 (n)
  • 50.47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPK1 35
  • 52.67 (n)
  • 54.17 (a)
YPK1 36
  • 27 (a)
ManyToMany
YPK2 36
  • 27 (a)
ManyToMany
YPK1 38
bread mold
(Neurospora crassa)
Ascomycetes NCU07280 35
  • 55.38 (n)
  • 53.29 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gad8 35
  • 52.1 (n)
  • 52.22 (a)
Species with no ortholog for SGK2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SGK2 Gene

ENSEMBL:
Gene Tree for SGK2 (if available)
TreeFam:
Gene Tree for SGK2 (if available)

Paralogs for SGK2 Gene

genes like me logo Genes that share paralogs with SGK2: view

Variants for SGK2 Gene

Sequence variations from dbSNP and Humsavar for SGK2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs33969356 - 43,566,349(+) AACCC(A/T)CAGGC intron-variant, reference, missense
VAR_041074 A lung adenocarcinoma sample
rs35793869 - 43,579,987(+) AGAAC(C/T)ATGTA reference, missense
rs1077832 -- 43,559,552(+) GTTTT(C/T)TCCTC intron-variant
rs763227 -- 43,576,421(-) AGCTG(C/T)GAGCC intron-variant

Variation tolerance for SGK2 Gene

Residual Variation Intolerance Score: 39.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.17% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for SGK2 Gene

Disorders for SGK2 Gene

Relevant External Links for SGK2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SGK2

No disorders were found for SGK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SGK2 Gene

Publications for SGK2 Gene

  1. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. (PMID: 10548550) Kobayashi T. … Cohen P. (Biochem. J. 1999) 2 3 4 67
  2. Serum- and glucocorticoid-inducible kinase SGK2 regulates human organic anion transporters 4 via ubiquitin ligase Nedd4-2. (PMID: 26740304) Wang H. … You G. (Biochem. Pharmacol. 2016) 2 3
  3. Statin-activated nuclear receptor PXR promotes SGK2 dephosphorylation by scaffolding PP2C to induce hepatic gluconeogenesis. (PMID: 26392083) Gotoh S. … Negishi M. (Sci Rep 2015) 2 3
  4. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  5. Serum- and glucocorticoid-regulated kinase 2 determines drug-activated pregnane X receptor to induce gluconeogenesis in human liver cells. (PMID: 24204015) Gotoh S. … Negishi M. (J. Pharmacol. Exp. Ther. 2014) 3

Products for SGK2 Gene

Sources for SGK2 Gene

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