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Aliases for SGK2 Gene

Aliases for SGK2 Gene

  • SGK2, Serine/Threonine Kinase 2 2 3 5
  • Serum/Glucocorticoid Regulated Kinase 2 2 3
  • EC 2.7.11.1 4 61
  • Serum/Glucocorticoid-Regulated Kinase 2 4
  • Serine/Threonine-Protein Kinase Sgk2 3
  • DJ138B7.2 3
  • EC 2.7.11 61
  • H-SGK2 3

External Ids for SGK2 Gene

Previous GeneCards Identifiers for SGK2 Gene

  • GC20P041916
  • GC20P042826
  • GC20P042873
  • GC20P041621
  • GC20P042187
  • GC20P038923

Summaries for SGK2 Gene

Entrez Gene Summary for SGK2 Gene

  • This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

GeneCards Summary for SGK2 Gene

SGK2 (SGK2, Serine/Threonine Kinase 2) is a Protein Coding gene. Among its related pathways are Ion channel transport and FoxO signaling pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is SGK1.

UniProtKB/Swiss-Prot for SGK2 Gene

  • Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase.

Gene Wiki entry for SGK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGK2 Gene

Genomics for SGK2 Gene

Regulatory Elements for SGK2 Gene

Enhancers for SGK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F043656 1.8 FANTOM5 Ensembl ENCODE 10.2 +98.7 98712 2.8 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 DEK IFT52 MYBL2 SGK2 OSER1 SRSF6 L3MBTL1 GC20P043655
GH20F043530 1 ENCODE 16.1 -28.0 -28000 1.5 MLX ARID4B DMAP1 ZNF48 SLC30A9 SP5 NFYC ZHX2 MXD4 MIER2 SGK2 RNU6-1251P L3MBTL1 GC20M043507 ENSG00000277611
GH20F044173 1.6 FANTOM5 Ensembl ENCODE 9.8 +622.8 622819 15.7 HDGF PKNOX1 MLX YBX1 DMAP1 ZNF48 ZNF121 ZNF302 ZNF207 SMARCA4 JPH2 FITM2 OSER1 SGK2 OSER1-AS1 GC20P044130
GH20F044089 1.3 FANTOM5 Ensembl ENCODE 9.9 +531.2 531233 0.8 USF1 MAX ZIC2 ZNF316 RBAK NFYB PRDM10 NFE2 FOS EGR2 MYBL2 SGK2 JPH2 GC20P044130 RN7SL443P
GH20F043555 1.6 FANTOM5 Ensembl ENCODE 7.1 -0.4 -354 6.2 HDGF MLX ARID4B DMAP1 YY1 SLC30A9 ZNF207 FOS SP5 NFYC IFT52 RNU6-1251P SGK2 ENSG00000226143
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SGK2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SGK2 Gene

Chromosome:
20
Start:
43,558,968 bp from pter
End:
43,588,237 bp from pter
Size:
29,270 bases
Orientation:
Plus strand

Genomic View for SGK2 Gene

Genes around SGK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGK2 Gene

Proteins for SGK2 Gene

  • Protein details for SGK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBY8-SGK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase Sgk2
    Protein Accession:
    Q9HBY8
    Secondary Accessions:
    • Q52PK5
    • Q5H8Y6
    • Q5H8Z1
    • Q5TZR3
    • Q9UKG6

    Protein attributes for SGK2 Gene

    Size:
    427 amino acids
    Molecular mass:
    47604 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SGK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SGK2 Gene

Selected DME Specific Peptides for SGK2 Gene

Q9HBY8:
  • GTPEYLAPE
  • NGGELFFHL
  • FYAVKVLQKK
  • VNGGELF
  • YLAPEVL
  • AFLGFSYA
  • EPRARFY
  • VDWWCLGAVLYEML
  • RDLKPEN
  • DFGLCKE
  • KPENILLD

Post-translational modifications for SGK2 Gene

  • Activated by phosphorylation on Ser-416 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-253.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SGK2 (SGK2)
  • Santa Cruz Biotechnology (SCBT) Antibodies for SGK2

Domains & Families for SGK2 Gene

Suggested Antigen Peptide Sequences for SGK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HBY8

UniProtKB/Swiss-Prot:

SGK2_HUMAN :
  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with SGK2: view

Function for SGK2 Gene

Molecular function for SGK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Two specific sites, one in the kinase domain (Thr-253) and the other in the C-terminal regulatory region (Ser-416), need to be phosphorylated for its full activation.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase.

Enzyme Numbers (IUBMB) for SGK2 Gene

Gene Ontology (GO) - Molecular Function for SGK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,TAS --
GO:0005246 calcium channel regulator activity IBA --
GO:0005524 ATP binding IEA --
GO:0015459 potassium channel regulator activity IDA 12397388
genes like me logo Genes that share ontologies with SGK2: view
genes like me logo Genes that share phenotypes with SGK2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SGK2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SGK2 Gene

Localization for SGK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SGK2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SGK2 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1

Gene Ontology (GO) - Cellular Components for SGK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular IBA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SGK2: view

Pathways & Interactions for SGK2 Gene

genes like me logo Genes that share pathways with SGK2: view

Pathways by source for SGK2 Gene

1 Cell Signaling Technology pathway for SGK2 Gene
1 BioSystems pathway for SGK2 Gene

SIGNOR curated interactions for SGK2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SGK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth TAS 20919962
GO:0006468 protein phosphorylation NAS 12397388
GO:0006883 cellular sodium ion homeostasis IBA --
GO:0006979 response to oxidative stress TAS 10548550
GO:0010765 positive regulation of sodium ion transport IBA --
genes like me logo Genes that share ontologies with SGK2: view

Drugs & Compounds for SGK2 Gene

(2) Drugs for SGK2 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
GSK 650394 Pharma SGK1 inhibitor, Serum- and glucocorticoid-regulated kinase (SGK) inhibitor 0

(1) Additional Compounds for SGK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(1) ApexBio Compounds for SGK2 Gene

Compound Action Cas Number
GSK 650394 SGK1 inhibitor 890842-28-1
genes like me logo Genes that share compounds with SGK2: view

Transcripts for SGK2 Gene

Unigene Clusters for SGK2 Gene

Serum/glucocorticoid regulated kinase 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SGK2 Gene

No ASD Table

Relevant External Links for SGK2 Gene

GeneLoc Exon Structure for
SGK2
ECgene alternative splicing isoforms for
SGK2

Expression for SGK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SGK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SGK2 Gene

This gene is overexpressed in Liver (x11.4), Kidney - Cortex (x8.1), and Colon - Transverse (x5.5).

Protein differential expression in normal tissues from HIPED for SGK2 Gene

This gene is overexpressed in Nasal epithelium (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SGK2 Gene



Protein tissue co-expression partners for SGK2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SGK2 Gene:

SGK2

SOURCE GeneReport for Unigene cluster for SGK2 Gene:

Hs.300863

mRNA Expression by UniProt/SwissProt for SGK2 Gene:

Q9HBY8-SGK2_HUMAN
Tissue specificity: Highly expressed in liver, kidney and pancreas, and at lower levels in brain.
genes like me logo Genes that share expression patterns with SGK2: view

Orthologs for SGK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SGK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SGK2 34 35
  • 99.27 (n)
cow
(Bos Taurus)
Mammalia SGK2 34 35
  • 90.92 (n)
dog
(Canis familiaris)
Mammalia SGK2 34
  • 90.9 (n)
mouse
(Mus musculus)
Mammalia Sgk2 34 16 35
  • 89.16 (n)
rat
(Rattus norvegicus)
Mammalia Sgk2 34
  • 88.16 (n)
oppossum
(Monodelphis domestica)
Mammalia SGK2 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SGK2 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves SGK2 34 35
  • 76.92 (n)
lizard
(Anolis carolinensis)
Reptilia SGK2 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sgk2 34
  • 74.4 (n)
Str.5294 34
zebrafish
(Danio rerio)
Actinopterygii sgk2a 34 35
  • 68.83 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9898 34
worm
(Caenorhabditis elegans)
Secernentea W10G6.2 36
  • 54 (a)
sgk-1 35
  • 39 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL028W 34
  • 54.93 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B12716g 34
  • 53.4 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPK1 34 35 37
  • 52.67 (n)
YPK2 35
  • 27 (a)
ManyToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU07280 34
  • 55.38 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gad8 34
  • 52.1 (n)
Species where no ortholog for SGK2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SGK2 Gene

ENSEMBL:
Gene Tree for SGK2 (if available)
TreeFam:
Gene Tree for SGK2 (if available)

Paralogs for SGK2 Gene

genes like me logo Genes that share paralogs with SGK2: view

Variants for SGK2 Gene

Sequence variations from dbSNP and Humsavar for SGK2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_041074 A lung adenocarcinoma sample
rs10523244 -- 43,579,035(+) TTTTT(-/T)GAGAC intron-variant
rs10664352 -- 43,566,917(+) AGGGA(-/CGGA)GGCGG intron-variant
rs1077832 -- 43,559,552(+) GTTTT(C/T)TCCTC intron-variant
rs11086882 -- 43,557,029(+) AAAAA(A/T)TGGAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SGK2 Gene

Variant ID Type Subtype PubMed ID
nsv1057847 CNV loss 25217958

Variation tolerance for SGK2 Gene

Residual Variation Intolerance Score: 39.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SGK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SGK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SGK2 Gene

Disorders for SGK2 Gene

Relevant External Links for SGK2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SGK2

No disorders were found for SGK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SGK2 Gene

Publications for SGK2 Gene

  1. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. (PMID: 10548550) Kobayashi T. … Cohen P. (Biochem. J. 1999) 2 3 4 64
  2. Serum- and glucocorticoid-inducible kinase SGK2 regulates human organic anion transporters 4 via ubiquitin ligase Nedd4-2. (PMID: 26740304) Wang H. … You G. (Biochem. Pharmacol. 2016) 2 3 64
  3. Statin-activated nuclear receptor PXR promotes SGK2 dephosphorylation by scaffolding PP2C to induce hepatic gluconeogenesis. (PMID: 26392083) Gotoh S. … Negishi M. (Sci Rep 2015) 2 3 64
  4. The serum and glucocorticoid inducible kinases SGK1-3 stimulate the neutral amino acid transporter SLC6A19. (PMID: 20511718) Boehmer C. … Palmada M. (Cell. Physiol. Biochem. 2010) 3 4 64
  5. Second AKT: the rise of SGK in cancer signalling. (PMID: 20919962) Bruhn M.A. … Sheppard K.E. (Growth Factors 2010) 3 4 64

Products for SGK2 Gene

Sources for SGK2 Gene

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