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SGK2 Gene

protein-coding   GIFtS: 60
GCID: GC20P042187

Serum/Glucocorticoid Regulated Kinase 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Serum/Glucocorticoid Regulated Kinase 21 2     Serine/Threonine-Protein Kinase Sgk22
EC 2.7.11.13 8     Serum/Glucocorticoid-Regulated Kinase 23
H-SGK22     EC 2.7.118
dJ138B7.22     

External Ids:    HGNC: 139001   Entrez Gene: 101102   Ensembl: ENSG000001010497   OMIM: 6075895   UniProtKB: Q9HBY83   
ORGUL members:         

Export aliases for SGK2 gene to outside databases

Previous GC identifers: GC20P041916 GC20P042826 GC20P042873 GC20P041621 GC20P038923


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SGK2 Gene:
This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and
glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is
induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Nov 2010)

GeneCards Summary for SGK2 Gene:
SGK2 (serum/glucocorticoid regulated kinase 2) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and sodium channel regulator activity. An important paralog of this gene is AKT1.

UniProtKB/Swiss-Prot: SGK2_HUMAN, Q9HBY8
Function: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels,
membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+)
channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4,
glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase

Gene Wiki entry for SGK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the SGK2 gene promoter:
         GR   NF-1/L   NF-1   USF1   GR-beta   FAC1   USF-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SGK2 promoter sequence
   Search Chromatin IP Primers for SGK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SGK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.2   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.2

SGK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SGK2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P042187:  view genomic region     (about GC identifiers)

Start:
42,187,608 bp from pter      End:
42,216,877 bp from pter
Size:
29,270 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for SGK2

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SGK2_HUMAN, Q9HBY8 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase Sgk2  
Size: 427 amino acids; 47604 Da
Caution: Not regulated by serum or glucocorticoids
Secondary accessions: Q52PK5 Q5H8Y6 Q5H8Z1 Q5TZR3 Q9UKG6
Alternative splicing: 3 isoforms:  Q9HBY8-1   Q9HBY8-2   Q9HBY8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SGK2: NX_Q9HBY8

Explore proteomics data for SGK2 at MOPED

Post-translational modifications: 

  • Activated by phosphorylation on Ser-416 by an unknown kinase (may be mTORC2 but not confirmed), transforming it
    into a substrate for PDPK1 which then phosphorylates it on Thr-2531
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SGK2 (Q9HBY8) (see all 11)
     EPRARFY  VNGGELF  YLAPEVL  RDLKPEN 


    See SGK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001186193.1  NP_057360.2  NP_733794.1  

    ENSEMBL proteins: 
     ENSP00000362192   ENSP00000362184   ENSP00000436841   ENSP00000362168   ENSP00000396222  
     ENSP00000340608   ENSP00000412214   ENSP00000392795  
    Reactome Protein details: Q9HBY8

    SGK2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SGK2

     
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    antibodies-online proteins for SGK2 (8 products) 

     
    antibodies-online peptides for SGK2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: serum/glucocorticoid regulated kinase 2
    SGK family
    Other AGC kinases

    Selected InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C
     IPR008271 Ser/Thr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry Q9HBY8

    ProtoNet protein and cluster: Q9HBY8

    1 Blocks protein domain: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: SGK2_HUMAN, Q9HBY8
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with SGK2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SGK2_HUMAN, Q9HBY8
    Function: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels,
    membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+)
    channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4,
    glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Two specific sites, one in the kinase domain (Thr-253) and the other in the C-terminal
    regulatory region (Ser-416), need to be phosphorylated for its full activation

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
    GO:0015459potassium channel regulator activity IDA12397388
         
    Find genes that share ontologies with SGK2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for SGK2:
     Increased cell death HMECs cel  Increased colony dispersion (i  Synthetic lethal with c-Myc af 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SGK2

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    1 qRT-PCR Assays for microRNA that regulate SGK2:
    hsa-miR-466
    SwitchGear 3'UTR luciferase reporter plasmidSGK2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SGK2

    Gene Editing
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    Addgene plasmids for SGK2 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SGK2_HUMAN, Q9HBY8: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with SGK2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SGK2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    3PI3K / Akt Signaling
    PI3K / Akt Signaling
    4PI3K-Akt signaling pathway
    PI3K-Akt signaling pathway
    5Insulin Signaling
    Insulin Signaling


    Find genes that share SuperPaths with SGK2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SGK2
        PI3K / Akt Signaling

    1 BioSystems Pathway for SGK2
        Insulin Signaling

    1 Reactome Pathway for SGK2
        Stimuli-sensing channels


    2 Kegg Pathways  (Kegg details for SGK2):
        FoxO signaling pathway
    PI3K-Akt signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including SGK2: 
              Nitric Oxide Signaling Pathway in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SGK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SGK2 (Q9HBY83 ENSP000003406084) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDPK1O155303, ENSP000003442204I2D: score=1 STRING: ENSP00000344220
    ITCHENSP000003639984STRING: ENSP00000363998
    JAZF1ENSP000002839284STRING: ENSP00000283928
    MAF1ENSP000003186044STRING: ENSP00000318604
    MAPKAP1ENSP000002659604STRING: ENSP00000265960
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth TAS--
    GO:0006468protein phosphorylation NAS12397388
    GO:0006979response to oxidative stress TAS10548550
    GO:0032411positive regulation of transporter activity TAS16460280
    GO:0034220ion transmembrane transport TAS--

    Find genes that share ontologies with SGK2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for SGK2
      Browse compounds at ApexBio 

    Browse Tocris compounds for SGK2

    2 HMDB Compounds for SGK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    Find genes that share compounds with SGK2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SGK2 gene (3 alternative transcripts): 
    NM_001199264.1  NM_016276.3  NM_170693.2  

    Unigene Cluster for SGK2:

    Serum/glucocorticoid regulated kinase 2
    Hs.300863  [show with all ESTs]
    Unigene Representative Sequence: BC006523
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373100(uc002xkr.3 uc010ggm.3 uc002xkt.3 uc002xku.3)
    ENST00000373092 ENST00000496343 ENST00000373077 ENST00000412111 ENST00000341458(uc002xkv.3)
    ENST00000485914 ENST00000426287 ENST00000423407(uc002xkq.1)
    miRNA
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    hsa-miR-466
    SwitchGear 3'UTR luciferase reporter plasmidSGK2 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF169034.2 AF186470.1 AK289596.1 AK308502.1 AY987010.1 BC006523.2 BC014037.2 BC042809.1 
    BC065511.1 BT020098.1 

    10 DOTS entries:

    DT.409831  DT.100748082  DT.102652  DT.97794288  DT.100709439  DT.100836482  DT.102827897  DT.91894629 
    DT.120838200  DT.75175072 

    Selected AceView cDNA sequences (see all 71):

    BX099171 BC065511 BG323229 CR625759 AW296147 BX405926 AI650283 NM_016276 
    BM796040 AI631895 AI670884 AI668634 BX957013 BC014037 CR613964 AW195815 
    BC006523 AW152408 AI732394 BI762252 BI763213 BG422762 AI813357 AI733685 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SGK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTCTTCAG
    SGK2 Expression
    About this image


    SGK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebellum
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
    SGK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SGK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.300863

    UniProtKB/Swiss-Prot: SGK2_HUMAN, Q9HBY8
    Tissue specificity: Highly expressed in liver, kidney and pancreas, and at lower levels in brain

        Pathway & Disease-focused RT2 Profiler PCR Array including SGK2: 
              Nitric Oxide Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SGK2 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sgk21 , 5 serum/glucocorticoid regulated kinase 21, 5 89.16(n)1
    94.26(a)1
      2 (83.93 cM)5
    272191  NM_013731.21  NP_038759.11 
     1629873305 
    chicken
    (Gallus gallus)
    Aves SGK21 serum/glucocorticoid regulated kinase 2 76.92(n)
    82.97(a)
      419166  XM_004946999.1  XP_004947056.1 
    lizard
    (Anolis carolinensis)
    Reptilia SGK26
    serum/glucocorticoid regulated kinase 2
    74(a)
    1 ↔ 1
    GL343365.1(592634-637962)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.52942 Transcribed sequence with moderate similarity to protein more 77.24(n)    BX732481.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sgk2a1 serum/glucocorticoid regulated kinase 2a 68.83(n)
    74.93(a)
      570956  NM_001113622.1  NP_001107094.1 
    worm
    (Caenorhabditis elegans)
    Secernentea W10G6.23 Protein kinase C terminal domain 54(a)   X(16285814-16290079)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YPK1(YKL126W)4
    YPK11
    Serine/threonine protein kinase that phosphorylates more4
    YPK11
    52.67(n)1
    54.17(a)1
      11(205707-207749)4
    8537331, 4  NP_012796.11, 4 


    ENSEMBL Gene Tree for SGK2 (if available)
    TreeFam Gene Tree for SGK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SGK2 gene
    AKT12  GRK72  RPS6KB12  GRK12  SGK32  GRK42  GRK62  C8orf44-SGK32  
    ADRBK22  AKT32  SGK12  RPS6KB22  GRK52  ADRBK12  AKT22  
    Selected SIMAP similar genes for SGK2 using alignment to 3 protein entries:     SGK2_HUMAN (see all proteins) (see all similar genes):
    SGK3    DKFZp781N0293    SGKL    SGK1    AKT3    AKT1
    PRKCZ    KIN27    PKN2    RPS6KA3    RPS6KA2    PRKACA
    STK32C    PRKACB    AKT2    RPS6KA6    PRKCH    STK38L

    Find genes that share paralogs with SGK2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SGK2 (see all 766)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0410744
    A lung adenocarcinoma sample4--see VAR_0410742 E K mis40--------
    rs1841582091,2
    --42154680(+) ATGGCC/TCATTT 1 -- us2k10--------
    rs31270631,2
    C,F,A,H--42154684(-) CAGAAA/TATGGG 1 -- us2k111Minor allele frequency- T:0.16NS EA NA 1080
    rs2012708801,2
    --42154689(+) TTTCT-/GGAAAA 1 -- us2k10--------
    rs58415071,2
    C--42154691(+) TCTGGA/-AAAAA 1 -- us2k1 trp33Minor allele frequency- -:0.17NA CSA 6
    rs1459196751,2
    --42154718(+) TAGATC/TAATAC 1 -- us2k10--------
    rs31354131,2
    F,H--42154862(+) ggctcA/C/Tctgaa 1 -- us2k14NS EA 420
    rs1490349361,2
    --42154872(+) AAGCTA/GCATCT 1 -- us2k10--------
    rs1119525991,2
    C,F--42154900(+) CTCCTG/ACCTCA 1 -- us2k12Minor allele frequency- A:0.50NA CSA 4
    rs1482267681,2
    --42154936(+) GCACTC/TGCCAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SGK2 (42187608 - 42216877 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SGK2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SGK2
    DNA2.0 Custom Variant and Variant Library Synthesis for SGK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607589    OMIM disorders: --


    Find genes that share disorders with SGK2           About GenesLikeMe


    Export disorders for SGK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SGK2 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with SGK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. (PubMed id 10548550)1, 2, 3 Kobayashi T.... Cohen P. (Biochem. J. 1999)
    2. The serum and glucocorticoid inducible kinases SGK1-3 stimulate the neutral amino acid transporter SLC6A19. (PubMed id 20511718)1, 2 Boehmer C.... Palmada M. (Cell. Physiol. Biochem. 2010)
    3. Sgk kinases and their role in epithelial transport. (PubMed id 16460280)1, 2 Loffing J.... Staub O. (Annu. Rev. Physiol. 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms. (PubMed id 12634932)1, 2 Embark H.M.... Lang F. (Pflugers Arch. 2003)
    6. The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC. (PubMed id 12632189)1, 2 Friedrich B.... Lang F. (Pflugers Arch. 2003)
    7. K(+) channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK. (PubMed id 12397388)1, 2 Gamper N.... Lang F. (Pflugers Arch. 2002)
    8. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    9. Serum- and glucocorticoid-regulated kinase 2 determines drug-activated pregnane X receptor to induce gluconeogenesis in human liver cells. (PubMed id 24204015)1 Gotoh S. and Negishi M. (J. Pharmacol. Exp. Ther. 2014)
    10. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10110 HGNC: 13900 AceView: SGK2 Ensembl:ENSG00000101049 euGenes: HUgn10110
    ECgene: SGK2 Kegg: 10110 H-InvDB: SGK2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SGK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SGK2 gene:
    Search GeneIP for patents involving SGK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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