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Aliases for SGK2 Gene

Aliases for SGK2 Gene

  • Serum/Glucocorticoid Regulated Kinase 2 2 3
  • EC 2.7.11.1 4 64
  • Serum/Glucocorticoid-Regulated Kinase 2 4
  • Serine/Threonine-Protein Kinase Sgk2 3
  • DJ138B7.2 3
  • EC 2.7.11 64
  • H-SGK2 3

External Ids for SGK2 Gene

Summaries for SGK2 Gene

Entrez Gene Summary for SGK2 Gene

  • This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

GeneCards Summary for SGK2 Gene

SGK2 (Serum/Glucocorticoid Regulated Kinase 2) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Insulin Signaling. GO annotations related to this gene include protein serine/threonine kinase activity and sodium channel regulator activity. An important paralog of this gene is AKT1.

UniProtKB/Swiss-Prot for SGK2 Gene

  • Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase.

Gene Wiki entry for SGK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGK2 Gene

Genomics for SGK2 Gene

Genomic Location for SGK2 Gene

Start:
43,558,968 bp from pter
End:
43,588,237 bp from pter
Size:
29,270 bases
Orientation:
Plus strand

Genomic View for SGK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SGK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGK2 Gene

Regulatory Elements for SGK2 Gene

Proteins for SGK2 Gene

  • Protein details for SGK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBY8-SGK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase Sgk2
    Protein Accession:
    Q9HBY8
    Secondary Accessions:
    • Q52PK5
    • Q5H8Y6
    • Q5H8Z1
    • Q5TZR3
    • Q9UKG6

    Protein attributes for SGK2 Gene

    Size:
    427 amino acids
    Molecular mass:
    47604 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SGK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SGK2 Gene

Proteomics data for SGK2 Gene at MOPED

Post-translational modifications for SGK2 Gene

  • Activated by phosphorylation on Ser-416 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-253.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for SGK2 Gene

UniProtKB/Swiss-Prot:

SGK2_HUMAN
Domain:
  • Contains 1 AGC-kinase C-terminal domain.:
    • Q9HBY8
  • Contains 1 protein kinase domain.:
    • Q9HBY8
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.:
    • Q9HBY8
genes like me logo Genes that share domains with SGK2: view

Function for SGK2 Gene

Molecular function for SGK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Two specific sites, one in the kinase domain (Thr-253) and the other in the C-terminal regulatory region (Ser-416), need to be phosphorylated for its full activation
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase.

Enzyme Numbers (IUBMB) for SGK2 Gene

Gene Ontology (GO) - Molecular Function for SGK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IEA --
GO:0015459 potassium channel regulator activity IDA 12397388
genes like me logo Genes that share ontologies with SGK2: view
genes like me logo Genes that share phenotypes with SGK2: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SGK2 Gene

Localization for SGK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SGK2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SGK2 Gene COMPARTMENTS Subcellular localization image for SGK2 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 1

Gene Ontology (GO) - Cellular Components for SGK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SGK2: view

Pathways for SGK2 Gene

genes like me logo Genes that share pathways with SGK2: view

Pathways by source for SGK2 Gene

1 Cell Signaling Technology pathway for SGK2 Gene
1 BioSystems pathway for SGK2 Gene

Gene Ontology (GO) - Biological Process for SGK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth TAS 20919962
GO:0006468 protein phosphorylation NAS 12397388
GO:0006979 response to oxidative stress TAS 10548550
GO:0032411 positive regulation of transporter activity TAS 16460280
GO:0034220 ion transmembrane transport TAS --
genes like me logo Genes that share ontologies with SGK2: view

Compounds for SGK2 Gene

(2) HMDB Compounds for SGK2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with SGK2: view

Transcripts for SGK2 Gene

Unigene Clusters for SGK2 Gene

Serum/glucocorticoid regulated kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SGK2 Gene

No ASD Table

Relevant External Links for SGK2 Gene

GeneLoc Exon Structure for
SGK2
ECgene alternative splicing isoforms for
SGK2

Expression for SGK2 Gene

mRNA expression in normal human tissues for SGK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SGK2 Gene

This gene is overexpressed in Liver (11.4), Kidney - Cortex (8.1), and Colon - Transverse (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SGK2 Gene

SOURCE GeneReport for Unigene cluster for SGK2 Gene Hs.300863

mRNA Expression by UniProt/SwissProt for SGK2 Gene

Q9HBY8-SGK2_HUMAN
Tissue specificity: Highly expressed in liver, kidney and pancreas, and at lower levels in brain.
genes like me logo Genes that share expressions with SGK2: view

Orthologs for SGK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SGK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SGK2 36
  • 99.27 (n)
  • 99.18 (a)
SGK2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SGK2 36
  • 90.92 (n)
  • 95.91 (a)
SGK2 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SGK2 36
  • 90.9 (n)
  • 92.86 (a)
mouse
(Mus musculus)
Mammalia Sgk2 36
  • 89.16 (n)
  • 94.26 (a)
Sgk2 16
Sgk2 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SGK2 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SGK2 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sgk2 36
  • 88.16 (n)
  • 93.72 (a)
chicken
(Gallus gallus)
Aves SGK2 36
  • 76.92 (n)
  • 82.97 (a)
SGK2 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SGK2 37
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sgk2 36
  • 74.4 (n)
  • 82.81 (a)
Str.5294 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9898 36
zebrafish
(Danio rerio)
Actinopterygii sgk2a 36
  • 68.83 (n)
  • 74.93 (a)
sgk2a 37
  • 74 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea sgk-1 37
  • 39 (a)
OneToMany
W10G6.2 38
  • 54 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL028W 36
  • 54.93 (n)
  • 54.4 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPK1 36
  • 52.67 (n)
  • 54.17 (a)
YPK1 37
  • 27 (a)
ManyToMany
YPK1 39
YPK2 37
  • 27 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B12716g 36
  • 53.4 (n)
  • 50.47 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07280 36
  • 55.38 (n)
  • 53.29 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gad8 36
  • 52.1 (n)
  • 52.22 (a)
Species with no ortholog for SGK2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SGK2 Gene

ENSEMBL:
Gene Tree for SGK2 (if available)
TreeFam:
Gene Tree for SGK2 (if available)

Paralogs for SGK2 Gene

genes like me logo Genes that share paralogs with SGK2: view

Variants for SGK2 Gene

Sequence variations from dbSNP and Humsavar for SGK2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs763227 -- 43,576,421(-) AGCTG(C/T)GAGCC intron-variant
rs763228 -- 43,557,583(-) AGCTG(C/G)TTAAA upstream-variant-2KB
rs916409 -- 43,574,802(-) CTGTA(C/T)GTGTG intron-variant
rs916410 -- 43,574,597(-) AAGCC(A/G)CAACA intron-variant
rs1077832 -- 43,559,552(+) GTTTT(C/T)TCCTC intron-variant

Relevant External Links for SGK2 Gene

HapMap Linkage Disequilibrium report
SGK2

No data available for Structural Variations from Database of Genomic Variants (DGV) for SGK2 Gene

Disorders for SGK2 Gene

No disorders were found for SGK2 Gene.

No data available for UniProtKB/Swiss-Prot for SGK2 Gene

Publications for SGK2 Gene

  1. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. (PMID: 10548550) Kobayashi T. … Cohen P. (Biochem. J. 1999) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. K(+) channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK. (PMID: 12397388) Gamper N. … Lang F. (Pflugers Arch. 2002) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The serum and glucocorticoid inducible kinases SGK1-3 stimulate the neutral amino acid transporter SLC6A19. (PMID: 20511718) Boehmer C. … Palmada M. (Cell. Physiol. Biochem. 2010) 3 4

Products for SGK2 Gene

  • Addgene plasmids for SGK2

Sources for SGK2 Gene

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