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Aliases for SGK1 Gene

Aliases for SGK1 Gene

  • Serum/Glucocorticoid Regulated Kinase 1 2 3
  • Serum/Glucocorticoid-Regulated Kinase 1 3 4
  • EC 2.7.11.1 4 63
  • SGK 3 4
  • Serum/Glucocorticoid Regulated Kinase 2
  • Serine/Threonine-Protein Kinase Sgk1 3
  • Serine/Threonine Protein Kinase SGK 3
  • Sgk1 Variant I3 3
  • EC 2.7.11 63

External Ids for SGK1 Gene

Previous Symbols for SGK1 Gene

  • SGK

Summaries for SGK1 Gene

Entrez Gene Summary for SGK1 Gene

  • This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]

GeneCards Summary for SGK1 Gene

SGK1 (Serum/Glucocorticoid Regulated Kinase 1) is a Protein Coding gene. Diseases associated with SGK1 include pseudohypoaldosteronism, type i. Among its related pathways are PI3K-Akt signaling pathway and IL-6 Signaling Pathway. GO annotations related to this gene include protein serine/threonine kinase activity and sodium channel regulator activity. An important paralog of this gene is AKT1.

UniProtKB/Swiss-Prot for SGK1 Gene

  • Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and up-regulates its activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates MAPK1/ERK2 and activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and plays an inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates SLC9A3/NHE3 in response to dexamethasone, resulting in its activation and increased localization at the cell membrane. Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Isoform 2 exhibited a greater effect on cell plasma membrane expression of SCNN1A/ENAC and Na(+) transport than isoform 1.

Gene Wiki entry for SGK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGK1 Gene

Genomics for SGK1 Gene

Genomic Location for SGK1 Gene

Start:
134,169,246 bp from pter
End:
134,318,112 bp from pter
Size:
148,867 bases
Orientation:
Minus strand

Genomic View for SGK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SGK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGK1 Gene

Regulatory Elements for SGK1 Gene

Proteins for SGK1 Gene

  • Protein details for SGK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00141-SGK1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase Sgk1
    Protein Accession:
    O00141
    Secondary Accessions:
    • B7UUP7
    • B7UUP8
    • B7UUP9
    • B7Z5B2
    • E1P583
    • Q5TCN2
    • Q5TCN3
    • Q5TCN4
    • Q5VY65
    • Q9UN56

    Protein attributes for SGK1 Gene

    Size:
    431 amino acids
    Molecular mass:
    48942 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Forms a trimeric complex with FBXW7 and NOTCH1. Interacts with MAPK3/ERK1, MAPK1/ERK2, MAP2K1/MEK1, MAP2K2/MEK2, NEDD4, NEDD4L, MAPT/TAU, MAPK7, CREB1, SLC9A3R2/NHERF2 and KCNJ1/ROMK1. Associates with the mammalian target of rapamycin complex 2 (mTORC2) via an interaction with MAPKAP1/SIN1.

    Three dimensional structures from OCA and Proteopedia for SGK1 Gene

    Alternative splice isoforms for SGK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SGK1 Gene

Proteomics data for SGK1 Gene at MOPED

Post-translational modifications for SGK1 Gene

  • Regulated by phosphorylation. Activated by phosphorylation on Ser-422 by mTORC2, transforming it into a substrate for PDPK1 which phosphorylates it on Thr-256. Phosphorylation on Ser-397 and Ser-401 are also essential for its activity. Phosphorylation on Ser-78 by MAPK7 is required for growth factor-induced cell cycle progression.
  • Ubiquitinated by NEDD4L; which promotes proteasomal degradation. Ubiquitinated by SYVN1 at the endoplasmic reticulum; which promotes rapid proteasomal degradation and maintains a high turnover rate in resting cells. Isoform 2 shows enhanced stability.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for SGK1 Gene

Suggested Antigen Peptide Sequences for SGK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00141

UniProtKB/Swiss-Prot:

SGK1_HUMAN
Domain:
  • Isoform 2 subcellular localization at the cell membrane and resistance to proteasomal degradation is mediated by the sequences within the first 120 amino acids:
    • O00141
  • Contains 1 AGC-kinase C-terminal domain.:
    • O00141
  • Contains 1 protein kinase domain.:
    • O00141
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.:
    • O00141
genes like me logo Genes that share domains with SGK1: view

Function for SGK1 Gene

Molecular function for SGK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Two specific sites, one in the kinase domain (Thr-256) and the other in the C-terminal regulatory region (Ser-422), need to be phosphorylated for its full activation. Phosphorylation at Ser-397 and Ser-401 are also essential for its activity. Activated by WNK1, WNK2, WNK3 and WNK4
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and up-regulates its activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates MAPK1/ERK2 and activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and plays an inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates SLC9A3/NHE3 in response to dexamethasone, resulting in its activation and increased localization at the cell membrane. Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Isoform 2 exhibited a greater effect on cell plasma membrane expression of SCNN1A/ENAC and Na(+) transport than isoform 1.
UniProtKB/Swiss-Prot Induction: Induced by a very large spectrum of stimuli distinct from glucocorticoids and serum. These include aldosterone, cell shrinkage, cell swelling, TGF-beta, ischemic injury of the brain, neuronal excitotoxicity memory consolidation, chronic viral hepatitis, DNA-damaging agents, vitamin D3 psychophysiological stress, iron, glucose, EDN1, CSF2, fibroblast growth factor, platelet-derived growth factor, phorbolesters, follicle-stimulating hormone, sorbitol, heat shock, oxidative stress, UV irradiation, and p53/TP53. Many of these stimuli are highly cell-specific, as is the case, for example for aldosterone, which has been found to stimulate its expression only in cells derived from aldosterone-responsive epithelia. Isoform 2 is not induced by glucocorticoids but by excessive extracellular glucose and by TGFB1, in cultured cells.

Enzyme Numbers (IUBMB) for SGK1 Gene

Gene Ontology (GO) - Molecular Function for SGK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004712 protein serine/threonine/tyrosine kinase activity IDA 22797923
GO:0004713 protein tyrosine kinase activity --
GO:0005246 calcium channel regulator activity TAS 20530112
genes like me logo Genes that share ontologies with SGK1: view

Phenotypes for SGK1 Gene

genes like me logo Genes that share phenotypes with SGK1: view

Animal Models for SGK1 Gene

MGI Knock Outs for SGK1:

miRNA for SGK1 Gene

miRTarBase miRNAs that target SGK1

No data available for Transcription Factor Targeting and HOMER Transcription for SGK1 Gene

Localization for SGK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SGK1 Gene

Cytoplasm. Nucleus. Endoplasmic reticulum membrane. Cell membrane. Mitochondrion. Note=The subcellular localization is controlled by the cell cycle, as well as by exposure to specific hormones and environmental stress stimuli. In proliferating cells, it shuttles between the nucleus and cytoplasm in synchrony with the cell cycle, and in serum/growth factor-stimulated cells it resides in the nucleus. In contrast, after exposure to environmental stress or treatment with glucocorticoids, it is detected in the cytoplasm and with certain stress conditions is associated with the mitochondria. In osmoregulation through the epithelial sodium channel, it can be localized to the cytoplasmic surface of the cell membrane. Nuclear, upon phosphorylation.
Isoform 2: Cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SGK1 Gene COMPARTMENTS Subcellular localization image for SGK1 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 5
nucleus 5
plasma membrane 5
cytosol 4
extracellular 2
endosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SGK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum --
genes like me logo Genes that share ontologies with SGK1: view

Pathways for SGK1 Gene

genes like me logo Genes that share pathways with SGK1: view

Gene Ontology (GO) - Biological Process for SGK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth TAS 20919962
GO:0006468 protein phosphorylation IEA --
GO:0006814 sodium ion transport TAS 10884438
GO:0006915 apoptotic process IEA --
GO:0006950 response to stress TAS 9114008
genes like me logo Genes that share ontologies with SGK1: view

Compounds for SGK1 Gene

(5) Tocris Compounds for SGK1 Gene

Compound Action Cas Number
(5Z)-7-Oxozeaenol Potent and selective TAK1 MAPKKK inhibitor [66018-38-0]
AZ 3146 Potent and selective monopolar spindle 1 (Mps1) kinase inhibitor [1124329-14-1]
CGP 57380 Selective inhibitor of Mnk1 [522629-08-9]
GSK 650394 Serum- and glucocorticoid-regulated kinase (SGK) inhibitor [890842-28-1]
IPA 3 Group I p21-activated kinase (PAK) inhibitor [42521-82-4]

(5) HMDB Compounds for SGK1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Aldosterone
  • (+)-Aldosterone
52-39-1
Chlorine
  • Cl2
16887-00-6
Sodium
  • Sodium
7440-23-5

(3) Drugbank Compounds for SGK1 Gene

(36) Novoseek inferred chemical compound relationships for SGK1 Gene

Compound -log(P) Hits PubMed IDs
pki-166 69.3 3
threonine 65.6 29
sodium 62.5 44
ly294002 61.6 5
rapamycin 60.8 10
genes like me logo Genes that share compounds with SGK1: view

Transcripts for SGK1 Gene

Unigene Clusters for SGK1 Gene

Serum/glucocorticoid regulated kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SGK1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - -
SP5: - -
SP6: - -
SP7: - -
SP8: - -
SP9: - -
SP10: -
SP11: -
SP12:
SP13: -
SP14: - -

ExUns: 14b ^ 15a · 15b
SP1: -
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for SGK1 Gene

GeneLoc Exon Structure for
SGK1
ECgene alternative splicing isoforms for
SGK1

Expression for SGK1 Gene

mRNA expression in normal human tissues for SGK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SGK1 Gene

SOURCE GeneReport for Unigene cluster for SGK1 Gene Hs.510078

mRNA Expression by UniProt/SwissProt for SGK1 Gene

O00141-SGK1_HUMAN
Tissue specificity: Expressed in most tissues with highest levels in the pancreas, followed by placenta, kidney and lung. Isoform 2 is strongly expressed in brain and pancreas, weaker in heart, placenta, lung, liver and skeletal muscle.
genes like me logo Genes that share expressions with SGK1: view

No data available for mRNA differential expression in normal tissues for SGK1 Gene

Orthologs for SGK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SGK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SGK1 35
  • 96.7 (n)
  • 96.38 (a)
SGK1 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SGK1 35
  • 91.79 (n)
  • 97.29 (a)
SGK1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SGK 36
  • 96 (a)
OneToOne
SGK1 35
  • 92.71 (n)
  • 96.39 (a)
mouse
(Mus musculus)
Mammalia Sgk1 35
  • 88.74 (n)
  • 94.47 (a)
Sgk1 16
Sgk1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SGK1 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SGK1 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sgk1 35
  • 88.59 (n)
  • 97.54 (a)
chicken
(Gallus gallus)
Aves SGK1 35
  • 84.56 (n)
  • 96.55 (a)
SGK1 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SGK1 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7842 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sgk1 35
  • 79.64 (n)
  • 91.38 (a)
Str.10900 35
zebrafish
(Danio rerio)
Actinopterygii sgk 35
sgk1 35
  • 76.85 (n)
  • 89.16 (a)
sgk1 36
  • 85 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea sgk-1 35
  • 55.5 (n)
  • 54.19 (a)
sgk-1 36
  • 45 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPK1 36
  • 29 (a)
ManyToMany
YPK2 36
  • 29 (a)
ManyToMany
Species with no ortholog for SGK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SGK1 Gene

ENSEMBL:
Gene Tree for SGK1 (if available)
TreeFam:
Gene Tree for SGK1 (if available)

Paralogs for SGK1 Gene

genes like me logo Genes that share paralogs with SGK1: view

Variants for SGK1 Gene

Sequence variations from dbSNP and Humsavar for SGK1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs229135 -- 134,318,130(-) AAGTA(A/G)CCCTC upstream-variant-2KB
rs734738 -- 134,247,783(-) TTAGT(A/G)AATGG intron-variant
rs744196 -- 134,247,078(+) ATTGA(C/G)GGGTC intron-variant
rs763023 -- 134,304,755(-) CCTTG(G/T)TTTTT intron-variant
rs880692 -- 134,307,932(-) TAGTA(C/G)ACGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SGK1 Gene

Variant ID Type Subtype PubMed ID
nsv441702 CNV CNV 18776908
dgv395n21 CNV Gain 19592680
dgv1152e199 CNV Deletion 23128226
esv25399 CNV Loss 19812545
esv2732732 CNV Deletion 23290073
esv1004173 CNV Deletion 20482838
nsv499444 CNV Loss 21111241
dgv1153e199 CNV Deletion 23128226
nsv823844 CNV Loss 20364138
nsv819323 CNV Loss 19587683
nsv514390 CNV Loss 21397061
esv2674292 CNV Deletion 23128226
dgv2010e1 CNV Complex 17122850
nsv7971 CNV Loss 18304495

Relevant External Links for SGK1 Gene

HapMap Linkage Disequilibrium report
SGK1
Human Gene Mutation Database (HGMD)
SGK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SGK1 Gene

Disorders for SGK1 Gene

(1) University of Copenhagen DISEASES for SGK1 Gene

(25) Novoseek inferred disease relationships for SGK1 Gene

Disease -log(P) Hits PubMed IDs
pseudohypoaldosteronism 74.9 1
diabetic nephropathies 39.7 10
cystic fibrosis 25.7 2
mammary tumor 22 4
hyperinsulinemia 6.11 1

Relevant External Links for SGK1

Genetic Association Database (GAD)
SGK1
Human Genome Epidemiology (HuGE) Navigator
SGK1
genes like me logo Genes that share disorders with SGK1: view

No data available for UniProtKB/Swiss-Prot for SGK1 Gene

Publications for SGK1 Gene

  1. Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume. (PMID: 9114008) Waldegger S. … Lang F. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23
  2. Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2. (PMID: 10191262) Kobayashi T. … Cohen P. (Biochem. J. 1999) 3 4 23
  3. Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf. (PMID: 11410590) Zhang B.H. … Guan K.L. (J. Biol. Chem. 2001) 3 4 23
  4. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. (PMID: 10548550) Kobayashi T. … Cohen P. (Biochem. J. 1999) 3 4 23
  5. Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel. (PMID: 11696533) Snyder P.M. … Thomas B.C. (J. Biol. Chem. 2002) 3 4 23

Products for SGK1 Gene

  • Addgene plasmids for SGK1

Sources for SGK1 Gene

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