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SGK1 Gene

protein-coding   GIFtS: 71
GCID: GC06M134490

Serum/Glucocorticoid Regulated Kinase 1

(Previous name: serum/glucocorticoid regulated kinase)
(Previous symbol: SGK)
  See SGK1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serum/Glucocorticoid Regulated Kinase 11 2     Serine/Threonine Protein Kinase SGK2
SGK1 2 3     Serine/Threonine-Protein Kinase Sgk12
Serum/Glucocorticoid-Regulated Kinase 12 3     Sgk1 Variant I32
EC 2.7.11.13 8     EC 2.7.118
Serum/Glucocorticoid Regulated Kinase1     

External Ids:    HGNC: 108101   Entrez Gene: 64462   Ensembl: ENSG000001185157   OMIM: 6029585   UniProtKB: O001413   

Export aliases for SGK1 gene to outside databases

Previous GC identifers: GC06M134533 GC06M132059


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SGK1 Gene:
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This
kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of
processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of
this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively
spliced transcript variants encoding different isoforms have been noted for this gene. (provided by RefSeq, Jan
2009)

GeneCards Summary for SGK1 Gene:
SGK1 (serum/glucocorticoid regulated kinase 1) is a protein-coding gene. Diseases associated with SGK1 include diabetic nephropathy, and hypertension. GO annotations related to this gene include protein serine/threonine kinase activity and sodium channel regulator activity. An important paralog of this gene is AKT1.

UniProtKB/Swiss-Prot: SGK1_HUMAN, O00141
Function: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels,
membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth,
proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response.
Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid
secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood
pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation.
Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and
KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate
transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters:
SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter:
SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6.
Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and
SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and transcription factors: CTNNB1 and
nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and
expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its
interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for
degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1
directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates
MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates microtubule
depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and up-regulates its
activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates MAPK1/ERK2 and
activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and plays an
inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the nucleus to
the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent
transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates SLC9A3/NHE3 in
response to dexamethasone, resulting in its activation and increased localization at the cell membrane.
Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis. Sustained high levels and activity
may contribute to conditions such as hypertension and diabetic nephropathy. Isoform 2 exhibited a greater effect
on cell plasma membrane expression of SCNN1A/ENAC and Na(+) transport than isoform 1

Gene Wiki entry for SGK1 (SGK) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SGK1 gene promoter:
         CREB   p53   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): SGK1 promoter sequence
   Search Chromatin IP Primers for SGK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SGK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23   Ensembl cytogenetic band:  6q23.2   HGNC cytogenetic band: 6q23

SGK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SGK1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M134490:  view genomic region     (about GC identifiers)

Start:
134,490,384 bp from pter      End:
134,639,250 bp from pter
Size:
148,867 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SGK1_HUMAN, O00141 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase Sgk1  
Size: 431 amino acids; 48942 Da
Subunit: Homodimer; disulfide-linked. Forms a trimeric complex with FBXW7 and NOTCH1. Interacts with MAPK3/ERK1,
MAPK1/ERK2, MAP2K1/MEK1, MAP2K2/MEK2, NEDD4, NEDD4L, MAPT/TAU, MAPK7, CREB1, SLC9A3R2/NHERF2 and KCNJ1/ROMK1.
Associates with the mammalian target of rapamycin complex 2 (mTORC2) via an interaction with MAPKAP1/SIN1
3 PDB 3D structures from and Proteopedia for SGK1:
2R5T (3D)        3HDM (3D)        3HDN (3D)    
Secondary accessions: B7UUP7 B7UUP8 B7UUP9 B7Z5B2 E1P583 Q5TCN2 Q5TCN3 Q5TCN4 Q5VY65 Q9UN56
Alternative promoter usage, Alternative splicing: 5 isoforms:  O00141-1   O00141-2   O00141-3   O00141-4   O00141-5   (Produced by alternative promoter usage)

Explore the universe of human proteins at neXtProt for SGK1: NX_O00141

Explore proteomics data for SGK1 at MOPED

Post-translational modifications: 

  • Regulated by phosphorylation. Activated by phosphorylation on Ser-422 by mTORC2, transforming it into a substrate
    for PDPK1 which phosphorylates it on Thr-256. Phosphorylation on Ser-397 and Ser-401 are also essential for its
    activity. Phosphorylation on Ser-78 by MAPK7 is required for growth factor-induced cell cycle progression1
  • Ubiquitinated by NEDD4L; which promotes proteasomal degradation. Ubiquitinated by SYVN1 at the endoplasmic
    reticulum; which promotes rapid proteasomal degradation and maintains a high turnover rate in resting cells.
    Isoform 2 shows enhanced stability1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SGK1 (O00141) (see all 15)
     FYAAEIA  EPRARFY  YLAPEVL  RDLKPEN 


    See SGK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001137148.1  NP_001137149.1  NP_001137150.1  NP_005618.2  

    ENSEMBL proteins: 
     ENSP00000356832   ENSP00000396242   ENSP00000237305   ENSP00000356831   ENSP00000434450  
     ENSP00000434302   ENSP00000435577   ENSP00000431705   ENSP00000435724   ENSP00000436470  
    Reactome Protein details: O00141

    SGK1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant SGK1 Protein
    R&D Systems Recombinant & Natural Proteins for SGK1 (SGK)
    Enzo Life Sciences proteins for SGK1
    OriGene Purified Protein for SGK1
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for SGK1
    OriGene Custom Protein Services for SGK1
    GenScript Custom Purified and Recombinant Proteins Services for SGK1
    Novus Biologicals SGK1 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SGK1
    Cloud-Clone Corp. Proteins for SGK1

     
    Search eBioscience for Proteins for SGK1 

     
    antibodies-online proteins for SGK1 (18 products) 

     
    antibodies-online peptides for SGK1

    SGK1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SGK1
    R&D Systems Antibodies for SGK1 (SGK)
    Cell Signaling Technology (CST) Antibodies for SGK1 
    OriGene Antibodies for SGK1
    OriGene Custom Antibody Services for SGK1
    Novus Biologicals SGK1 Antibodies
    Search for Antibodies for SGK1 at Abcam
    Cloud-Clone Corp. Antibodies for SGK1
    ThermoFisher Antibodies for SGK1
    antibodies-online antibodies for SGK1 (151 products) 

    SGK1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SGK1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SGK1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SGK1
    Cloud-Clone Corp. CLIAs for SGK1
    Search eBioscience for ELISAs for SGK1 
    antibodies-online kits for SGK1 (17 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

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    IUPHAR Guide to PHARMACOLOGY protein family classification: serum/glucocorticoid regulated kinase 1
    SGK family
    Other AGC kinases

    Selected InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C
     IPR008271 Ser/Thr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry O00141

    ProtoNet protein and cluster: O00141

    1 Blocks protein domain: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: SGK1_HUMAN, O00141
    Domain: Isoform 2 subcellular localization at the cell membrane and resistance to proteasomal degradation is
    mediated by the sequences within the first 120 amino acids
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with SGK1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SGK1_HUMAN, O00141
    Function: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels,
    membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth,
    proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response.
    Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid
    secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood
    pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation.
    Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and
    KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate
    transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters:
    SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter:
    SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6.
    Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and
    SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and transcription factors: CTNNB1 and
    nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and
    expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its
    interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for
    degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1
    directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates
    MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates microtubule
    depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and up-regulates its
    activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates MAPK1/ERK2 and
    activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and plays an
    inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the nucleus to
    the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent
    transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates SLC9A3/NHE3 in
    response to dexamethasone, resulting in its activation and increased localization at the cell membrane.
    Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis. Sustained high levels and activity
    may contribute to conditions such as hypertension and diabetic nephropathy. Isoform 2 exhibited a greater effect
    on cell plasma membrane expression of SCNN1A/ENAC and Na(+) transport than isoform 1
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Two specific sites, one in the kinase domain (Thr-256) and the other in the C-terminal
    regulatory region (Ser-422), need to be phosphorylated for its full activation. Phosphorylation at Ser-397 and
    Ser-401 are also essential for its activity. Activated by WNK1, WNK2, WNK3 and WNK4
    Induction: Induced by a very large spectrum of stimuli distinct from glucocorticoids and serum. These include
    aldosterone, cell shrinkage, cell swelling, TGF-beta, ischemic injury of the brain, neuronal excitotoxicity
    memory consolidation, chronic viral hepatitis, DNA-damaging agents, vitamin D3 psychophysiological stress, iron,
    glucose, EDN1, CSF2, fibroblast growth factor, platelet-derived growth factor, phorbolesters,
    follicle-stimulating hormone, sorbitol, heat shock, oxidative stress, UV irradiation, and p53/TP53. Many of these
    stimuli are highly cell-specific, as is the case, for example for aldosterone, which has been found to stimulate
    its expression only in cells derived from aldosterone-responsive epithelia. Isoform 2 is not induced by
    glucocorticoids but by excessive extracellular glucose and by TGFB1, in cultured cells

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005246calcium channel regulator activity TAS--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SGK1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SGK1:
     Increased apoptosis 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Sgk1):
     growth/size/body  homeostasis/metabolism  no phenotypic analysis  renal/urinary system 

    Find genes that share phenotypes with SGK1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SGK1: Sgk1tm1Kuhl Sgk1tm1.2Palm

       genOway: Develop your customized and physiologically relevant rodent model for SGK1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SGK1:
    hsa-mir-124-3p (MIRT022117)

    Block miRNA regulation of human, mouse, rat SGK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SGK1 (see all 55):
    hsa-miR-323-3p hsa-miR-576-3p hsa-miR-15a hsa-miR-25 hsa-miR-503 hsa-miR-29a hsa-let-7a-2* hsa-miR-486-3p
    SwitchGear 3'UTR luciferase reporter plasmidSGK1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SGK1
    Predesigned siRNA for gene silencing in human, mouse, rat SGK1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SGK1

    Clone
    Products:
         
    OriGene clones in human, mouse for SGK1 (see all 32)
    OriGene ORF clones in mouse, rat for SGK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): SGK1 (NM_001143676)
    Sino Biological Human cDNA Clone for SGK1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SGK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGK1
    Addgene plasmids for SGK1 

    Cell Line
    Products:
         
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SGK1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGK1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SGK1_HUMAN, O00141: Cytoplasm. Nucleus. Endoplasmic reticulum membrane. Cell membrane. Mitochondrion. Note=The
    subcellular localization is controlled by the cell cycle, as well as by exposure to specific hormones and
    environmental stress stimuli. In proliferating cells, it shuttles between the nucleus and cytoplasm in synchrony
    with the cell cycle, and in serum/growth factor-stimulated cells it resides in the nucleus. In contrast, after
    exposure to environmental stress or treatment with glucocorticoids, it is detected in the cytoplasm and with
    certain stress conditions is associated with the mitochondria. In osmoregulation through the epithelial sodium
    channel, it can be localized to the cytoplasmic surface of the cell membrane. Nuclear, upon phosphorylation
    SGK1_HUMAN, O00141: Isoform 2: Cell membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    mitochondrion5
    nucleus5
    plasma membrane5
    cytosol4
    extracellular2
    endosome1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0005789endoplasmic reticulum membrane IEA--

    Find genes that share ontologies with SGK1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SGK1 About   (see all 19)  
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    3Selected targets of p53
    Selected targets of p53
    4Selected targets of Oct 3 4
    Selected targets of Oct 3 4
    5Selected targets of CREB1
    Selected targets of CREB1


    Find genes that share SuperPaths with SGK1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for SGK1
        PI3K / Akt Signaling
    Glucose / Energy Metabolism

    Selected BioSystems Pathways for SGK1 (see all 8)
        Insulin Signaling
    IL-6 Signaling Pathway
    FSH signaling pathway
    mTOR signaling pathway
    Class I PI3K signaling events


    1 Reactome Pathway for SGK1
        Stimuli-sensing channels

    1 PharmGKB Pathway for SGK1
        Diuretics Pathway, Pharmacodynamics

    3 Kegg Pathways  (Kegg details for SGK1):
        FoxO signaling pathway
    PI3K-Akt signaling pathway
    Aldosterone-regulated sodium reabsorption

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SGK1: 
              mTOR Signaling in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Huntington's Disease in human mouse rat
              Osmotic Stress in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SGK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SGK1 (O001412, 3 ENSP000003568324) via UniProtKB, MINT, STRING, and/or I2D (see all 157)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000096171P266403I2D: score=1 
    ENSG00000224264P266403I2D: score=1 
    ENSG00000226589P266403I2D: score=1 
    ENSG00000231116P266403I2D: score=1 
    VARSP266403I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth TAS--
    GO:0006468protein phosphorylation TAS9114008
    GO:0006814sodium ion transport TAS10884438
    GO:0006915apoptotic process IEA--
    GO:0006950response to stress TAS9114008

    Find genes that share ontologies with SGK1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for SGK1
      Browse compounds at ApexBio 

    Compounds for SGK1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (5Z)-7-OxozeaenolPotent and selective TAK1 MAPKKK inhibitor[66018-38-0]
    GSK 650394Serum- and glucocorticoid-regulated kinase (SGK) inhibitor[890842-28-1]
    IPA 3Group I p21-activated kinase (PAK) inhibitor[42521-82-4]
    CGP 57380Selective inhibitor of Mnk1[522629-08-9]
    AZ 3146Potent and selective monopolar spindle 1 (Mps1) kinase inhibitor[1124329-14-1]

    5 HMDB Compounds for SGK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Aldosterone(+)-Aldosterone (see all 22)52-39-117202226
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    ChlorineCl2 (see all 13)16887-00-6--
    SodiumSodium (see all 2)7440-23-5--

    3 DrugBank Compounds for SGK1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid-- --target--10592235
    Riboflavin Monophosphate-- 146-17-8target--10592235
    [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for SGK1 gene (see all 36)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pki-166 69.3 3 16105029 (2), 17382577 (1)
    threonine 65.6 39 20416281 (3), 8647846 (2), 10608847 (2), 8455596 (2) (see all 24)
    sodium 62.5 56 10608847 (5), 18653620 (3), 18238849 (3), 12388075 (2) (see all 30)
    ly294002 61.6 9 18787837 (2), 18456663 (1), 10935551 (1), 15679045 (1)
    rapamycin 60.8 18 20338997 (2), 18925875 (2), 18570873 (2), 19584721 (1) (see all 7)
    serine 59.7 45 20416281 (3), 8647846 (2), 10608847 (2), 8455596 (2) (see all 34)
    phosphatidylinositol 53.5 14 16081417 (2), 10548550 (2), 12218062 (1), 17015487 (1) (see all 8)
    dexamethasone 51.2 43 16971495 (3), 12488318 (3), 19619128 (3), 11179908 (2) (see all 19)
    phosphoinositide 48.3 8 18456663 (1), 16895519 (1), 19619128 (1), 17356130 (1) (see all 6)
    phosphatidylinositol-3,4,5-trisphosphate 45.5 1 10074427 (1)



    Find genes that share compounds with SGK1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for SGK1 gene (4 alternative transcripts): 
    NM_001143676.1  NM_001143677.1  NM_001143678.1  NM_005627.3  

    Unigene Cluster for SGK1:

    Serum/glucocorticoid regulated kinase 1
    Hs.510078  [show with all ESTs]
    Unigene Representative Sequence: NM_001143676
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000367858(uc011ecw.2 uc003qeo.4) ENST00000474427 ENST00000413996(uc011ecv.2)
    ENST00000477460 ENST00000237305(uc003qen.4 uc011ecu.2) ENST00000367855
    ENST00000367857(uc011ect.2) ENST00000528577 ENST00000475719 ENST00000531782
    ENST00000473704 ENST00000525877 ENST00000489458 ENST00000524764 ENST00000475882
    ENST00000534658 ENST00000490149 ENST00000524387
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SGK1 (see all 55):
    hsa-miR-323-3p hsa-miR-576-3p hsa-miR-15a hsa-miR-25 hsa-miR-503 hsa-miR-29a hsa-let-7a-2* hsa-miR-486-3p
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    GenScript: all cDNA clones in your preferred vector (see all 4): SGK1 (NM_001143676)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGK1
    Addgene plasmids for SGK1 
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      QuantiFast Probe-based Assays in human, mouse, rat SGK1

    Additional mRNA sequence: 

    AF153609.1 AK055077.1 AK098509.1 AK293383.1 AK295422.1 AK298688.1 BC001263.1 BC013832.1 
    BX537882.1 EU518415.1 FM205707.1 FM205708.1 FM205709.1 FM205710.1 JQ836654.1 Y10032.1 

    Selected DOTS entries (see all 35):

    DT.100873674  DT.92462390  DT.100873685  DT.319593  DT.121395150  DT.100873680  DT.121395132  DT.92062009 
    DT.121395158  DT.121395163  DT.121395196  DT.97862328  DT.121395174  DT.100873673  DT.100873686  DT.100851660 
    DT.91972894  DT.100873677  DT.91660435  DT.95075276  DT.121395111  DT.121395123  DT.95151857  DT.100873687 

    Selected AceView cDNA sequences (see all 558):

    BG769533 BG575325 BM760147 AA887418 BQ720678 CB124600 CB243597 BM460788 
    BM771318 AA953375 BQ001235 AA371225 BM985237 AI678448 AI479297 AF153609 
    BF725499 AW302545 CA389917 AI167676 CR596295 BE892510 N27967 AL040857 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SGK1 (see all 14)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a ·
    SP1:                          -           -                             -           -     -                       -                             -               
    SP2:              -           -           -                             -           -     -                       -                                             
    SP3:        -     -           -           -                             -           -     -                                                                     
    SP4:                                                                                                              -                             -               
    SP5:                                                                                                              -                             -               

    ExUns: 14b ^ 15a · 15b
    SP1:  -               
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:  -               


    ECgene alternative splicing isoforms for SGK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SGK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTATAATAC
    SGK1 Expression
    About this image


    SGK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Granulosa Cells Primary Follicle
             Secondary follicles
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Inner Cell Mass Cells Inner Cell Mass
             Human embryonic stem cells (family)
     
     Hypoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Extraembryonic Visceral Endoderm Cells Extraembryonic Visceral Endoderm
             Extraembryonic Visceral Endoderm
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Medulla Oblongata
     
     Kidney (Urinary System)
             Interstitial Stroma
    SGK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SGK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.510078

    UniProtKB/Swiss-Prot: SGK1_HUMAN, O00141
    Tissue specificity: Expressed in most tissues with highest levels in the pancreas, followed by placenta, kidney
    and lung. Isoform 2 is strongly expressed in brain and pancreas, weaker in heart, placenta, lung, liver and
    skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SGK1: 
              mTOR Signaling in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Huntington's Disease in human mouse rat
              Osmotic Stress in human mouse rat

    Primer
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SGK1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sgk11 , 5 serum/glucocorticoid regulated kinase 11, 5 88.74(n)1
    94.47(a)1
      10 (9.83 cM)5
    203931  NM_001161845.21  NP_001155317.21 
     218821845 
    chicken
    (Gallus gallus)
    Aves SGK11 serum/glucocorticoid regulated kinase 1 84.56(n)
    96.55(a)
      395133  NM_204476.1  NP_989807.1 
    lizard
    (Anolis carolinensis)
    Reptilia SGK16
    serum/glucocorticoid regulated kinase 1
    90(a)
    1 ↔ 1
    GL343200.1(3617268-3712618)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.78422 Xenopus laevis unknown mRNA 79.91(n)    AF057138.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sgk2 serum/glucocorticoid regulated kinase 77.21(n)   324140  BC052134.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sgk-11 sgk-1 55.5(n)
    54.19(a)
      181697  NM_001047833.4  NP_001041298.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YPK26
    YPK16
    Protein kinase with similarity to serine/threonine...
    Serine/threonine protein kinase that phosphorylate...
    29(a)
    29(a)
    many ↔ many
    many ↔ many
    XIII(473420-475453) YMR104C
    XI(205707-207749) YKL126W


    ENSEMBL Gene Tree for SGK1 (if available)
    TreeFam Gene Tree for SGK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SGK1 gene
    AKT12  GRK72  RPS6KB12  GRK12  SGK32  GRK42  GRK62  C8orf44-SGK32  
    SGK22  ADRBK22  AKT32  RPS6KB22  GRK52  ADRBK12  AKT22  
    Selected SIMAP similar genes for SGK1 using alignment to 6 protein entries:     SGK1_HUMAN (see all proteins) (see all similar genes):
    DKFZp686M0890    SGK    DKFZp686H1615    SGK2    DKFZp781N0293    SGKL
    PKN2    SGK3    PNCK    RPS6KA2    PRKCI    RPS6KA6
    PRKACA    MARK4    PRKCZ    PRKCB    RPS6KA3    PRKCH

    Find genes that share paralogs with SGK1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SGK1 (see all 3185)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1144959431,2
    F--134489948(+) TGGAAG/AGGCGA 4 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1900973901,2
    --134489951(+) AAGGGC/TGAAGT 4 -- ds50010--------
    rs1122639811,2
    C,F--134489953(+) GGGCGC/AAGTTG 4 -- ds50011Minor allele frequency- A:0.50WA 2
    rs69113751,2
    C,F,A,H--134489975(+) CACTAC/TGATAT 4 -- ds500117Minor allele frequency- T:0.05NS EA NA WA 2134
    rs1816662341,2
    --134490112(+) GAAGCA/GTTACT 4 -- ds50010--------
    rs1386796721,2
    C--134490129(+) CAATCC/TTTGCA 4 -- ds50010--------
    rs801106631,2
    F--134490166(+) TTGGAT/CGGATT 4 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1410741641,2
    --134490447(+) AAAAAG/TTTGTG 4 -- ut310--------
    rs755919001,2
    C--134490551(+) AAATAC/TACTAG 4 -- ut310--------
    rs1180559871,2
    F--134490553(+) ATATAC/TTAGTG 4 -- ut311Minor allele frequency- T:0.01NA 120

    HapMap Linkage Disequilibrium report for SGK1 (134490384 - 134639250 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SGK1 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1152e199CNV Deletion23128226
    dgv1153e199CNV Deletion23128226
    esv2674292CNV Deletion23128226
    esv2732732CNV Deletion23290073
    esv1004173CNV Deletion20482838
    nsv823844CNV Loss20364138
    nsv819323CNV Loss19587683
    nsv514390CNV Loss21397061
    nsv7971CNV Loss18304495
    nsv499444CNV Loss21111241

    Human Gene Mutation Database (HGMD): SGK1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SGK1
    DNA2.0 Custom Variant and Variant Library Synthesis for SGK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602958    OMIM disorders: --

    2 diseases for SGK1:    
    About MalaCards
    diabetic nephropathy    hypertension

    1 disease from the University of Copenhagen DISEASES database for SGK1:
    Hypertension

    Find genes that share disorders with SGK1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SGK1 gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pseudohypoaldosteronism 74.9 1 17317952 (1)
    diabetic nephropathies 39.7 11 10589686 (2), 18238849 (2), 18653620 (1), 17170520 (1) (see all 8)
    cystic fibrosis 25.7 3 17595519 (1), 20021289 (1)
    mammary tumor 22 7 9114008 (1), 11278764 (1), 10357815 (1), 8455596 (1)
    hyperinsulinemia 6.11 1 16221215 (1)
    niddm 0 2 16105029 (1), 18985156 (1)
    insulin resistance 0 2 15167446 (1), 11551807 (1)
    essential hypertension 0 1 12215463 (1)
    ischemia 0 4 19764891 (1), 20021289 (1), 17015487 (1), 15504348 (1)
    renal failure chronic 0 1 15304560 (1)

    Genetic Association Database (GAD): SGK1
    Human Genome Epidemiology (HuGE) Navigator: SGK1 (9 documents)

    Export disorders for SGK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for SGK1 gene, integrated from 10 sources (see all 335):
    (articles sorted by number of sources associating them with SGK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume. (PubMed id 9114008)1, 2, 3, 9 Waldegger S.... Lang F. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    2. Genomic organization and chromosomal localization of the human SGK protein kinase gene. (PubMed id 9722955)1, 2, 3 Waldegger S.... Lang F. (Genomics 1998)
    3. Nedd4-2 phosphorylation induces serum and glucocorticoid-regulated kinase (SGK) ubiquitination and degradation. (PubMed id 15576372)1, 2, 9 Zhou R. and Snyder P.M. (J. Biol. Chem. 2005)
    4. Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2. (PubMed id 10191262)1, 2, 9 Kobayashi T. and Cohen P. (Biochem. J. 1999)
    5. mTOR complex-2 activates ENaC by phosphorylating SGK1. (PubMed id 20338997)1, 2, 9 Lu M.... Pearce D. (J. Am. Soc. Nephrol. 2010)
    6. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. (PubMed id 10548550)1, 2, 9 Kobayashi T.... Cohen P. (Biochem. J. 1999)
    7. Protein kinase SGK1 enhances MEK/ERK complex formation through the phosphorylation of ERK2: implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration. (PubMed id 19447520)1, 2, 9 Won M....Hur G.M. (J. Hepatol. 2009)
    8. Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms. (PubMed id 12590200)1, 2, 9 Henke G.... Lang F. (Kidney Blood Press. Res. 2002)
    9. Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf. (PubMed id 11410590)1, 2, 9 Zhang B.H.... Guan K.L. (J. Biol. Chem. 2001)
    10. Regulation of a third conserved phosphorylation site in SGK1. (PubMed id 19068477)1, 2, 9 Chen W.... Cobb M.H. (J. Biol. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6446 HGNC: 10810 AceView: SGK Ensembl:ENSG00000118515 euGenes: HUgn6446
    ECgene: SGK1 Kegg: 6446 H-InvDB: SGK1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SGK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SGK1 gene:
    Search GeneIP for patents involving SGK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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