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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SGK1 Gene

protein-coding   GIFtS: 70
GCID: GC06M134490

serum/glucocorticoid regulated kinase 1

(Previous name: serum/glucocorticoid regulated kinase )
(Previous symbol: SGK)
 Explore 34 diseases affiliated with
SGK1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SGK1    

Aliases
for SGK1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Serum/Glucocorticoid Regulated Kinase 11 2     Serine/Threonine Protein Kinase SGK2
SGK1 2 3     Serine/Threonine-Protein Kinase Sgk12
Serum/Glucocorticoid-Regulated Kinase 12 3     Sgk1 Variant I32
EC 2.7.11.13 8     EC 2.7.118
Serum/Glucocorticoid Regulated Kinase1     

External Ids:    HGNC: 108101   Entrez Gene: 64462   Ensembl: ENSG000001185157   OMIM: 6029585   UniProtKB: O001413   

Export aliases for SGK1 gene to outside databases

Previous GC identifers: GC06M134533 GC06M132059


Summaries
for SGK1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SGK1:
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This
kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of
processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this
gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced
transcript variants encoding different isoforms have been noted for this gene. (provided by RefSeq, Jan 2009)

UniProtKB/Swiss-Prot: SGK1_HUMAN, O00141
Function: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels,
membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation,
survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of
renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange
and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose
uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and
ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6,
chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3,
SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter:
SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B,
glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT,
SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and
transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by
enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3
ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and
targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates
KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2.
Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates
microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and
up-regulates its activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates
MAPK1/ERK2 and activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and
plays an inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the
nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with
FOXO3-dependent transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates
SLC9A3/NHE3 in response to dexamethasone, resulting in its activation and increased localization at the cell membrane.
Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis. Sustained high levels and activity may
contribute to conditions such as hypertension and diabetic nephropathy. Isoform 2 exhibited a greater effect on cell
plasma membrane expression of SCNN1A/ENAC and Na(+) transport than isoform 1

Gene Wiki entry for SGK1 (SGK)


Genomic Views
for SGK1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SGK1 gene promoter:
         CREB   p53   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): SGK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SGK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SGK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23   Ensembl cytogenetic band:  6q23.2   HGNC cytogenetic band: 6q23

SGK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SGK1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M134490:  view genomic region     (about GC identifiers)

Start:
 134,490,384 bp from pter      End:
 134,639,250 bp from pter
Size:
 148,867 bases      Orientation:
 minus strand

Proteins
for SGK1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SGK1_HUMAN, O00141 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase Sgk1  
Size: 431 amino acids; 48942 Da
Subunit: Homodimer; disulfide-linked. Forms a trimeric complex with FBXW7 and NOTCH1. Interacts with MAPK3/ERK1,
MAPK1/ERK2, MAP2K1/MEK1, MAP2K2/MEK2, NEDD4, NEDD4L, MAPT/TAU, MAPK7, CREB1, SLC9A3R2/NHERF2 and KCNJ1/ROMK1.
Associates with the mammalian target of rapamycin complex 2 (mTORC2) via an interaction with MAPKAP1/SIN1
Subcellular location: Cytoplasm. Nucleus. Endoplasmic reticulum membrane. Cell membrane. Mitochondrion. Note=The
subcellular localization is controlled by the cell cycle, as well as by exposure to specific hormones and
environmental stress stimuli. In proliferating cells, it shuttles between the nucleus and cytoplasm in synchrony with
the cell cycle, and in serum/growth factor-stimulated cells it resides in the nucleus. In contrast, after exposure to
environmental stress or treatment with glucocorticoids, it is detected in the cytoplasm and with certain stress
conditions is associated with the mitochondria. In osmoregulation through the epithelial sodium channel, it can be
localized to the cytoplasmic surface of the cell membrane. Nuclear, upon phosphorylation
Subcellular location: Isoform 2: Cell membrane
3 PDB 3D structures from and Proteopedia for SGK1:
2R5T (3D)        3HDM (3D)        3HDN (3D)    
Secondary accessions: B7UUP7 B7UUP8 B7UUP9 B7Z5B2 E1P583 Q5TCN2 Q5TCN3 Q5TCN4 Q5VY65 Q9UN56
Alternative promoter usage, Alternative splicing: 5 isoforms:  O00141-1   O00141-2   O00141-3   O00141-4   O00141-5   (Produced by alternative promoter usage)

Explore the universe of human proteins at neXtProt for SGK1: NX_O00141

Post-translational modifications:

  • Regulated by phosphorylation. Activated by phosphorylation on Ser-422 by mTORC2, transforming it into a substrate for
    • PDPK1 which phosphorylates it on Thr-256. Phosphorylation on Ser-397 and Ser-401 are also essential for its activity.
    Phosphorylation on Ser-78 by MAPK7 is required for growth factor-induced cell cycle progression1
  • Ubiquitinated by NEDD4L; which promotes proteasomal degradation. Ubiquitinated by SYVN1 at the endoplasmic reticulum;
    • which promotes rapid proteasomal degradation and maintains a high turnover rate in resting cells. Isoform 2 shows
    enhanced stability1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O00141

    • 4/15 DME Specific Peptides for SGK1 (O00141) (see all 15)
     FYAAEIA  EPRARFY  YLAPEVL  RDLKPEN 

    SGK1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001137148.1  NP_001137149.1  NP_001137150.1  NP_005618.2  

    ENSEMBL proteins: 
     ENSP00000356832   ENSP00000396242   ENSP00000237305   ENSP00000356831   ENSP00000434450  
     ENSP00000434302   ENSP00000435577   ENSP00000431705   ENSP00000435724   ENSP00000436470  
    Reactome Protein details: O00141
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant SGK1 Protein
    R&D Systems Recombinant & Natural Proteins for SGK1 (SGK)
    Enzo Life Sciences proteins for SGK1
    OriGene Purified Protein: SGK1
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for SGK1 
    GenScript Custom Purified and Recombinant Proteins Services for SGK1
    Novus Biologicals SGK1 Proteins
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for SGK1
    Uscn Proteins for SGK1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005739mitochondrion IEA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005886plasma membrane IEA--


    SGK1 for ontologies           About GeneDecksing



    SGK1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of SGK1
    R&D Systems Antibodies for SGK1 (SGK)
    Cell Signaling Technology (CST) Antibodies for SGK1 
    OriGene Antibodies: SGK1
    OriGene Custom Antibody Services for SGK1 
    GenScript Custom Superior Antibodies Services for SGK1
    Novus Biologicals SGK1 Antibodies
    Abcam antibodies for SGK1 
    Uscn Antibodies for SGK1
    ThermoFisher Antibodies for SGK1

    Assay Products for SGK1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SGK1
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    Uscn ELISAs and CLIAs for SGK1

    Protein Domains /
    Families
    for SGK1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SGK1 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR000961 AGC-kinase_C
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C

    Graphical View of Domain Structure for InterPro Entry O00141

    ProtoNet protein and cluster: O00141

    1 Blocks protein family: IPB000961 Protein kinase C-terminal domain

    UniProtKB/Swiss-Prot: SGK1_HUMAN, O00141
    Domain: Isoform 2 subcellular localization at the cell membrane and resistance to proteasomal degradation is mediated
    by the sequences within the first 120 amino acids
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 protein kinase domain


    Function
    for SGK1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SGK1_HUMAN, O00141
    Function: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels,
    membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation,
    survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of
    renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange
    and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose
    uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and
    ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6,
    chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3,
    SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter:
    SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B,
    glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT,
    SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and
    transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by
    enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3
    ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and
    targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates
    KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2.
    Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates
    microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and
    up-regulates its activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates
    MAPK1/ERK2 and activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and
    plays an inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the
    nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with
    FOXO3-dependent transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates
    SLC9A3/NHE3 in response to dexamethasone, resulting in its activation and increased localization at the cell membrane.
    Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis. Sustained high levels and activity may
    contribute to conditions such as hypertension and diabetic nephropathy. Isoform 2 exhibited a greater effect on cell
    plasma membrane expression of SCNN1A/ENAC and Na(+) transport than isoform 1
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Two specific sites, one in the kinase domain (Thr-256) and the other in the C-terminal regulatory
    region (Ser-422), need to be phosphorylated for its full activation. Phosphorylation at Ser-397 and Ser-401 are also
    essential for its activity. Activated by WNK1, WNK2, WNK3 and WNK4
    Induction: Induced by a very large spectrum of stimuli distinct from glucocorticoids and serum. These include
    aldosterone, cell shrinkage, cell swelling, TGF-beta, ischemic injury of the brain, neuronal excitotoxicity memory
    consolidation, chronic viral hepatitis, DNA-damaging agents, vitamin D3 psychophysiological stress, iron, glucose,
    EDN1, CSF2, fibroblast growth factor, platelet-derived growth factor, phorbolesters, follicle-stimulating hormone,
    sorbitol, heat shock, oxidative stress, UV irradiation, and p53/TP53. Many of these stimuli are highly cell-specific,
    as is the case, for example for aldosterone, which has been found to stimulate its expression only in cells derived
    from aldosterone-responsive epithelia. Isoform 2 is not induced by glucocorticoids but by excessive extracellular
    glucose and by TGFB1, in cultured cells

    Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 4): SGK1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SGK1
    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate SGK1 (see all 55):
    hsa-miR-323-3p hsa-miR-576-3p hsa-miR-15a hsa-miR-25 hsa-miR-503 hsa-miR-29a hsa-let-7a-2* hsa-miR-486-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SGK1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SGK1 (see all 4)
    OriGene shRNA RFP: SGK1
    OriGene siRNA: SGK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SGK1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SGK1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SGK1 (see all 11)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SGK1 (see all 8)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): SGK1 (NM_001143676)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGK1 

    Cell Line
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    Search LifeMap BioReagents cell lines for SGK1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGK1

    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0005246calcium channel regulator activity TAS--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--


    SGK1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SGK1:
     Increased apoptosis 

    Animal Models:
         Mouse knock-outs for SGK1: Sgk1tm1Kuhl Sgk1tm1.2Palm
         4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Sgk1):
     growth/size  homeostasis/metabolism  no phenotypic analysis  renal/urinary system 

    SGK1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SGK1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ion channel transport
    		Ion channel transport1.00
    		Stimuli-sensing channels0.49
    2Glucose / Energy Metabolism
    		Glucose / Energy Metabolism1.00
    3PI3K / Akt Signaling
    		PI3K / Akt Signaling1.00
    4Diuretics Pathway, Pharmacodynamics
    		Diuretics Pathway, Pharmacodynamics1.00
    5Selected targets of Oct-3/4
    		Selected targets of Oct-3/41.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for SGK1
        Selected targets of Oct-3/4
    Selected targets of CREB1
    Selected targets of p53


    2 Cell Signaling Technology (CST) Pathways for SGK1
        PI3K / Akt Signaling
    Glucose / Energy Metabolism

    5/8 BioSystems Pathways for SGK1 (see all 8) 
        FSH signaling pathway
    Insulin Signaling
    IL-6 Signaling Pathway
    Insulin Pathway
    FoxO family signaling

    3        Reactome Pathways for SGK1
        Transmembrane transport of small molecules
    Stimuli-sensing channels
    Ion channel transport

    1 PharmGKB Pathway for SGK1
        Diuretics Pathway, Pharmacodynamics

    1         Kegg Pathway  (Kegg details for SGK1):
        Aldosterone-regulated sodium reabsorption


    SGK1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SGK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/107 Interacting proteins for SGK1 (O001412, 3 ENSP000003568324) via UniProtKB, MINT, STRING, and/or I2D (see all 107)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB1P162202, 3, ENSP000003876994MINT-56642 MINT-56643 I2D: score=2 STRING: ENSP00000387699
    PDPK1O155303, ENSP000003442204I2D: score=5 STRING: ENSP00000344220
    MAPK7Q131643, ENSP000003110054I2D: score=3 STRING: ENSP00000311005
    BRAFP150563, ENSP000002886024I2D: score=2 STRING: ENSP00000288602
    FOXO3O435243, ENSP000003395274I2D: score=2 STRING: ENSP00000339527
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth TAS--
    GO:0006468protein phosphorylation TAS9114008
    GO:0006814sodium ion transport TAS10884438
    GO:0006915apoptotic process IEA--
    GO:0006950response to stress TAS9114008


    SGK1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SGK1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SGK1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for SGK1

    Compounds for SGK1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GSK 650394Serum- and glucocorticoid-regulated kinase (SGK) inhibitor[890842-28-1]

    5 HMDB Compounds for SGK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Aldosterone(+)-Aldosterone (see all 22)52-39-117202226
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    ChlorineCl2 (see all 13)16887-00-6--
    SodiumSodium (see all 2)7440-23-5--

    3 DrugBank Compounds for SGK1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid-- --target--10592235
    Riboflavin Monophosphate-- 146-17-8target--10592235
    [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid-- --target--10592235

    10/36 Novoseek chemical compound relationships for SGK1 gene (see all 36)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pki-166 69.3 3 16105029 (2), 17382577 (1)
    threonine 65.6 39 20416281 (3), 8647846 (2), 10608847 (2), 8455596 (2) (see all 24)
    sodium 62.5 56 10608847 (5), 18653620 (3), 18238849 (3), 12388075 (2) (see all 30)
    ly294002 61.6 9 18787837 (2), 18456663 (1), 10935551 (1), 15679045 (1)
    rapamycin 60.8 18 20338997 (2), 18925875 (2), 18570873 (2), 19584721 (1) (see all 7)
    serine 59.7 45 20416281 (3), 8647846 (2), 10608847 (2), 8455596 (2) (see all 34)
    phosphatidylinositol 53.5 14 16081417 (2), 10548550 (2), 12218062 (1), 17015487 (1) (see all 8)
    dexamethasone 51.2 43 16971495 (3), 12488318 (3), 19619128 (3), 11179908 (2) (see all 19)
    phosphoinositide 48.3 8 18456663 (1), 16895519 (1), 19619128 (1), 17356130 (1) (see all 6)
    phosphatidylinositol-3,4,5-trisphosphate 45.5 1 10074427 (1)

    Search CenterWatch for drugs/clinical trials and news about SGK1 

    Transcripts
    for SGK1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SGK1 gene (4 alternative transcripts): 
    NM_001143676.1  NM_001143677.1  NM_001143678.1  NM_005627.3  

    Unigene Cluster for SGK1:

    Serum/glucocorticoid regulated kinase 1
    Hs.510078  [show with all ESTs]
    Unigene Representative Sequence: NM_001143676
    18/30 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000367858(uc011ecw.2 uc003qeo.4) ENST00000474427 ENST00000413996(uc011ecv.2)
    ENST00000477460 ENST00000237305(uc003qen.4 uc011ecu.2) ENST00000367855
    ENST00000367857(uc011ect.2) ENST00000528577 ENST00000475719 ENST00000531782
    ENST00000473704 ENST00000525877 ENST00000489458 ENST00000524764 ENST00000475882
    ENST00000534658 ENST00000490149 ENST00000524387

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 4): SGK1
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    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate SGK1 (see all 55):
    hsa-miR-323-3p hsa-miR-576-3p hsa-miR-15a hsa-miR-25 hsa-miR-503 hsa-miR-29a hsa-let-7a-2* hsa-miR-486-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SGK1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SGK1 (see all 4)
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SGK1
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): SGK1 (NM_001143676)
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    Additional cDNA sequence: 

    AF153609.1 AK055077.1 AK098509.1 AK293383.1 AK295422.1 AK298688.1 BC001263.1 BC013832.1 
    BX537882.1 EU518415.1 FM205707.1 FM205708.1 FM205709.1 FM205710.1 JQ836654.1 Y10032.1 

    24/35 DOTS entries (see all 35):

    DT.100873674  DT.92462390  DT.100873685  DT.319593  DT.121395150  DT.100873680  DT.121395132  DT.92062009 
    DT.121395158  DT.121395163  DT.121395196  DT.97862328  DT.121395174  DT.100873673  DT.100873686  DT.100851660 
    DT.91972894  DT.100873677  DT.91660435  DT.95075276  DT.121395111  DT.121395123  DT.95151857  DT.100873687 

    24/558 AceView cDNA sequences (see all 558):

    AA605052 AU280667 NM_005627 BX439033 AA953375 BG769533 AI167676 BQ677816 
    AA887418 CB216289 BM973959 BE384761 BQ680126 AI092578 AA724007 AI479297 
    BG575325 BQ936977 BF725499 CF272410 BC001263 BU069438 AI202068 BG762465 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for SGK1 (see all 14)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a ·
    SP1:                          -           -                             -           -     -                       -                             -               
    SP2:              -           -           -                             -           -     -                       -                                             
    SP3:        -     -           -           -                             -           -     -                                                                     
    SP4:                                                                                                              -                             -               
    SP5:                                                                                                              -                             -               

    ExUns: 14b ^ 15a · 15b
    SP1:  -               
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:  -               


    ECgene alternative splicing isoforms for SGK1

    Expression
    for SGK1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SGK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTATAATAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SGK1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    9 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
    OvaryAntral FollicleCumulus CellsOvary
    OvaryPrimary FollicleGranulosa CellsOvary
    BrainChoroid PlexusBrain
    BrainMedulla OblongataBrain
    KidneyInterstitial StromaKidney
    LimbAutopodLimb
    Neural TubeDiencephalic Roof PlateNeural Tube
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    CyT49 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Secondary follicles (Primary Cell)Ovary, Reproductive System

    See SGK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SGK1

    SOURCE GeneReport for Unigene cluster: Hs.510078

    UniProtKB/Swiss-Prot: SGK1_HUMAN, O00141
    Tissue specificity: Expressed in most tissues with highest levels in the pancreas, followed by placenta, kidney and
    lung. Isoform 2 is strongly expressed in brain and pancreas, weaker in heart, placenta, lung, liver and skeletal
    muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including SGK1: 
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              Huntington's Disease in human mouse rat
              Osmotic Stress in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGK1

    Orthologs
    for SGK1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SGK1 gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SGK11 serum/glucocorticoid regulated kinase 1 84.56(n)
    96.55(a)    		   395133  NM_204476.1  NP_989807.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SGK16
    		 --
    		 92(a)
    		 1 ↔ 1
    		 GL343200.1(3703999-3710338)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.78422 Xenopus laevis unknown mRNA 79.91(n)    AF057138.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii sgk2 serum/glucocorticoid regulated kinase 77.21(n)   324140  BC052134.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea sgk-11 Protein SGK-1 55.5(n)
    54.19(a)    		   181697  NM_001047834.1  NP_001041299.1 


    ENSEMBL Gene Tree for SGK1 (if available)
    TreeFam Gene Tree for SGK1 (if available) 

    Paralogs
    for SGK1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SGK1 gene
    AKT12  RPS6KA62  RPS6KB12  SGK32  SGK22  RPS6KA12  AKT32  RPS6KA52  
    RPS6KA42  RPS6KB22  RPS6KA22  AKT22  RPS6KA32  
    18/82 SIMAP similar genes for SGK1 using alignment to 5 protein entries:     SGK1_HUMAN (see all proteins) (see all similar genes):
    DKFZp686M0890    SGK    DKFZp686H1615    SGK2    DKFZp781N0293    SGKL
    PKN2    SGK3    PNCK    RPS6KA2    PRKCI    RPS6KA6
    PRKACA    MARK4    PRKCB    RPS6KA3    PRKG1    PRKCH

    SGK1 for paralogs           About GeneDecksing



    Genomic Variants
    for SGK1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2675 NCBI SNPs in SGK1 are shown (see all 2675)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1144959431,2
    		F,--134489948(+) TGGAAG/AGGCGA 4 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1900973901,2
    		--134489951(+) AAGGGC/TGAAGT 4 -- ds50010--------
    rs1122639811,2
    		C,--134489953(+) GGGCGC/AAGTTG 4 -- ds50011Minor allele frequency- A:0.50WA 2
    rs69113751,2
    		C,F,A,H,--134489975(+) CACTAC/TGATAT 4 -- ds500117Minor allele frequency- T:0.05NS EA NA WA 2134
    rs1816662341,2
    		--134490112(+) GAAGCA/GTTACT 4 -- ds50010--------
    rs1386796721,2
    		--134490129(+) CAATCC/TTTGCA 4 -- ds50010--------
    rs801106631,2
    		--134490166(+) TTGGAT/CGGATT 4 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1410741641,2
    		--134490447(+) AAAAAG/TTTGTG 4 -- ut310--------
    rs755919001,2
    		--134490551(+) AAATAC/TACTAG 4 -- ut310--------
    rs1180559871,2
    		--134490553(+) ATATAC/TTAGTG 4 -- ut311Minor allele frequency- T:0.01NA 120

    HapMap Linkage Disequilibrium report for SGK1 (134490384 - 134639250 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for SGK1
         6 CNVs: 94036 3640 59296 51806 64665 37978
         1 Indel: 33822
    Human Gene Mutation Database (HGMD): SGK1

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for SGK1

    Disorders / Diseases
    for SGK1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SGK1 for disorders           About GeneDecksing

    OMIM gene information: 602958    OMIM disorders: --

    20/34 diseases for SGK1 (see all 34):    About MalaCards
    nephropathy    hypertension    pseudohypoaldosteronism type i    pseudohypoaldosteronism
    insulin resistance    cystic fibrosis    fanconi's anemia    neuronitis
    viral hepatitis    chorioamnionitis    hyperglycemia    neurodegeneration
    neurodegenerative disease    huntington's disease    fibrosis    osteosarcoma
    breast cancer    ischemia    kidney cancer    aldosteronism

    1 disease from the University of Copenhagen DISEASES database for SGK1:
    Hypertension

    10/25 Novoseek disease relationships for SGK1 gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pseudohypoaldosteronism 74.9 1 17317952 (1)
    diabetic nephropathies 39.7 11 10589686 (2), 18238849 (2), 18653620 (1), 17170520 (1) (see all 8)
    cystic fibrosis 25.7 3 17595519 (1), 20021289 (1)
    mammary tumor 22 7 9114008 (1), 11278764 (1), 10357815 (1), 8455596 (1)
    hyperinsulinemia 6.11 1 16221215 (1)
    niddm 0 2 16105029 (1), 18985156 (1)
    insulin resistance 0 2 15167446 (1), 11551807 (1)
    essential hypertension 0 1 12215463 (1)
    ischemia 0 4 19764891 (1), 20021289 (1), 17015487 (1), 15504348 (1)
    renal failure chronic 0 1 15304560 (1)

    Human Genome Epidemiology (HuGE) Navigator: SGK1 (9 documents)

    Export disorders for SGK1 gene to outside databases

    Publications
    for SGK1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SGK1 gene, integrated from 9 sources (see all 309):
    (articles sorted by number of sources associating them with SGK1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume. (PubMed id 9114008)1, 2, 3, 9 Waldegger S.... Lang F. (1997)
    2. Genomic organization and chromosomal localization of the human SGK protein kinase gene. (PubMed id 9722955)1, 2, 3 Waldegger S.... Lang F. (1998)
    3. Nedd4-2 phosphorylation induces serum and glucocorticoid-regulated kinase (SGK) ubiquitination and degradation. (PubMed id 15576372)1, 2, 9 Zhou R. and Snyder P.M. (2005)
    4. Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2. (PubMed id 10191262)1, 2, 9 Kobayashi T. and Cohen P. (1999)
    5. mTOR complex-2 activates ENaC by phosphorylating SGK1 . (PubMed id 20338997)1, 2, 9 Lu M....Pearce D. (2010)
    6. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. (PubMed id 10548550)1, 2, 9 Kobayashi T.... Cohen P. (1999)
    7. Protein kinase SGK1 enhances MEK/ERK complex formatio n through the phosphorylation of ERK2: implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration. (PubMed id 19447520)1, 2, 9 Won M....Hur G.M. (2009)
    8. Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms. (PubMed id 12590200)1, 2, 9 Henke G....Lang F. (2002)
    9. Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf. (PubMed id 11410590)1, 2, 9 Zhang B.H....Guan K.L. (2001)
    10. Regulation of a third conserved phosphorylation site in SGK1. (PubMed id 19068477)1, 2, 9 Chen W....Cobb M.H. (2009)

    External Searches for SGK1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SGK1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6446 HGNC: 10810 AceView: SGK Ensembl:ENSG00000118515 euGenes: HUgn6446
    ECgene: SGK1 Kegg: 6446 H-InvDB: SGK1

    Other Databases showing SGK1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SGK1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SGK1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SGK1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SGK1 gene:
    Search GeneIP for patents involving SGK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SGK1 gene

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    About This Section

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