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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SGIP1 Gene

protein-coding GIFtS: 50
GCID: GC01P066999

SH3-domain GRB2-like (endophilin) interacting protein 1

Explore 2 diseases affiliated with
SGIP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
SH3-Domain GRB2-Like (Endophilin) Interacting Protein 1¹ ²
Endophilin-3-Interacting Protein² ³
DKFZp761D221¹
SH3-Containing GRB2-Like Protein 3-Interacting Protein 1²

External Ids:	HGNC: 25412¹	Entrez Gene: 84251²	Ensembl: ENSG00000118473⁷	OMIM: 611540⁵	UniProtKB: Q9BQI5³

Export aliases for SGIP1 gene to outside databases

Previous GC identifers: GC00U915585 GC01P066712 GC01P065109

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SGIP1:

SGIP1 functions as an endocytic protein that affects signaling by receptors in neuronal systems involved in energy

homeostasis via its interaction with endophilins (see SH3GL3; MIM 603362) (Trevaskis et al., 2005 (PubMed 15919751)

and Uezu et al., 2007 (PubMed 17626015)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: SGIP1_HUMAN, Q9BQI5

Function: May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the

ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for

membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin

receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis (By similarity)

Gene Wiki entry for SGIP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SGIP1 gene promoter:
USF1 C/EBPbeta AML1a HSF1 (long) Tal-1beta Evi-1 E47 USF-1 COMP1 HSF1short
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SGIP1 promoter sequence

Search SABiosciences Chromatin IP Primers for SGIP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SGIP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3 Ensembl cytogenetic band: 1p31.3 HGNC cytogenetic band: 1p31.3

SGIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SGIP1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P066999: view genomic region (about GC identifiers)

Start:	66,999,066 bp from pter	End:	67,213,982 bp from pter
Size:	214,917 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SGIP1_HUMAN, Q9BQI5 (See protein sequence)

Recommended Name: SH3-containing GRB2-like protein 3-interacting protein 1

Size: 828 amino acids; 89109 Da

Subunit: Interacts with proteins essential or regulating the formation of functional clathrin-coated pits. Interacts

with CANX (By similarity). Interacts with AP2A1 (By similarity). Interacts with EPS15 (By similarity). Interacts with

SH3GL3. Interacts with AMPH. Interacts with ITSN1 (via SH3 domains). Interacts with and REPS1

Subcellular location: Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side (Probable)

Sequence caution: Sequence=BAE06121.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: A6NL81 A6NLD1 Q4LE32 Q5VYE2 Q5VYE3 Q5VYE4 Q68D76 Q6MZY6 Q8IWC2

Alternative splicing: 5 isoforms: Q9BQI5-1 Q9BQI5-2 Q9BQI5-3 Q9BQI5-4 Q9BQI5-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SGIP1: NX_Q9BQI5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BQI5

SGIP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_115667.2

ENSEMBL proteins:

ENSP00000237247 ENSP00000360078 ENSP00000410439 ENSP00000360076 ENSP00000395525

ENSP00000360074 ENSP00000360075

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	Uscn Proteins for SGIP1

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	--
GO:0005886	plasma membrane	IDA	--
GO:0005905	coated pit	IDA	--
GO:0030122	AP-2 adaptor complex	ISS	--
GO:0030136	clathrin-coated vesicle	ISS	--

SGIP1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SGIP1 for domains About GeneDecksing

1 InterPro domain/family:

IPR018808 Muniscin_C-term_mu_dom

Graphical View of Domain Structure for InterPro Entry Q9BQI5

ProtoNet protein and cluster: Q9BQI5

1 Blocks protein family: IPB008160 Collagen triple helix repeat

UniProtKB/Swiss-Prot: SGIP1_HUMAN, Q9BQI5

Similarity: Contains 1 MUHD (Muniscin C-terminal mu homology domain) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SGIP1_HUMAN, Q9BQI5

Function: May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the

ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for

membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin

receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: SGIP1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SGIP1
		8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate SGIP1 (see all 48):
		hsa-miR-3607-3p hsa-miR-429 hsa-miR-4272 hsa-miR-519a hsa-miR-500a hsa-miR-1243 hsa-miR-1183 hsa-miR-200b

		SwitchGear 3'UTR luciferase reporter plasmid: SGIP1 3' UTR sequence

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SGIP1 (see all 4) OriGene shRNA RFP: SGIP1 OriGene siRNA: SGIP1
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGIP1

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	15919751
GO:0005543	phospholipid binding	ISS	--
GO:0008017	microtubule binding	ISS	--
GO:0015631	tubulin binding	--	--
GO:0017124	SH3 domain binding	IPI	--

SGIP1 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SGIP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/69 Interacting proteins for SGIP1 (Q9BQI5³ ENSP00000360076⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 69)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GRB2	P62993³	I2D: score=2
PHB	P35232³	I2D: score=1
YWHAB	P31946³	I2D: score=1
AFTPH	ENSP00000238855⁴	STRING: ENSP00000238855
AP1G1	ENSP00000377148⁴	STRING: ENSP00000377148

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002021	response to dietary excess	ISS	--
GO:0006897	endocytosis	IEA	--
GO:0048260	positive regulation of receptor-mediated endocytosis	ISS	--
GO:2000253	positive regulation of feeding behavior	ISS	--
GO:2000507	positive regulation of energy homeostasis	ISS	--

SGIP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SGIP1
Search CenterWatch for drugs/clinical trials and news about SGIP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SGIP1 gene:

NM_032291.2

Unigene Cluster for SGIP1:

SH3-domain GRB2-like (endophilin) interacting protein 1

Hs.132121 [show with all ESTs]

Unigene Representative Sequence: AB210039

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000237247 ENST00000371039(uc001dct.3) ENST00000493564 ENST00000424320

ENST00000468286 ENST00000497055 ENST00000371037(uc001dcr.3 uc010opd.2 uc001dcs.3 uc009wat.3)

ENST00000484988 ENST00000483060 ENST00000480548 ENST00000487507 ENST00000435165(uc001dcu.3)

ENST00000320161 ENST00000468570 ENST00000371035 ENST00000371036

miRNA Products:		OriGene 3'-UTR Clone: SGIP1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SGIP1
		8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate SGIP1 (see all 48):
		hsa-miR-3607-3p hsa-miR-429 hsa-miR-4272 hsa-miR-519a hsa-miR-500a hsa-miR-1243 hsa-miR-1183 hsa-miR-200b

		SwitchGear 3'UTR luciferase reporter plasmid: SGIP1 3' UTR sequence

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Additional cDNA sequence:

AB210039.1 AK090697.1 AK125044.1 AK298970.1 AK299941.1 AL136561.1 BC040516.1 BX640813.1

CR749541.1

18 DOTS entries:

DT.300250 DT.101977408 DT.40122976 DT.97818383 DT.97837254 DT.100707067 DT.100751777 DT.99959796

DT.100733782 DT.102828380 DT.121360717 DT.40128900 DT.75171357 DT.95233599 DT.91681076 DT.97811811

DT.97825419 DT.101957447

24/104 AceView cDNA sequences (see all 104):

BU728721 AK090697 AX746580 BM695055 BQ639995 BM680994 BX108437 BQ437636

AK125044 BX460244 W45716 BM671405 AL711418 BM725988 CF129395 AL558074

BX640813 BX103189 BM703265 AA001702 BM666838 AW955735 BM692836 CR622141

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SGIP1 (see all 8) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14a	·	14b	^	15	^	16	^	17	^	18	^	19	^	20	^	21
SP1:																					-						-				-		-		-
SP2:																																			-
SP3:																					-
SP4:
SP5:

ECgene alternative splicing isoforms for SGIP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SGIP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGAAAACAG

About this image

SGIP1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Podocyte Layer

Presumptive Podocytes

Kidney

Kidney

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

Primitive gut tube-like cells (A scalable, suspensi...)

See SGIP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SGIP1

SOURCE GeneReport for Unigene cluster: Hs.132121

UniProtKB/Swiss-Prot: SGIP1_HUMAN, Q9BQI5

Tissue specificity: Specifically expressed in brain

SABiosciences Custom PCR Arrays for SGIP1

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SGIP1 gene from 6/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SGIP1¹	SH3-domain GRB2-like (endophilin) interacting protein more	76.23(n) 85.04(a)		776038 XM_001235603.2 XP_001235604.2
lizard (Anolis carolinensis)	Reptilia	SGIP1⁶	--	85(a)	1 ↔ 1	GL343410.1(290054-397711)
African clawed frog (Xenopus laevis)	Amphibia	BJ626274.1²	--	76.3(n)		BJ626274.1
zebrafish (Danio rerio)	Actinopterygii	BX510915.2⁶	--	65(a)	1 ↔ 1	2(14312207-14432336)
fruit fly (Drosophila melanogaster)	Insecta	CG8176⁶	--	16(a)	possible ortholog	3R(5341758-5352964)
worm (Caenorhabditis elegans)	Secernentea	F56D12.6⁶	Protein F56D12.6, isoform a	15(a)	1 → many	II(1310542-1320445)

ENSEMBL Gene Tree for SGIP1 (if available)
TreeFam Gene Tree for SGIP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SGIP1 gene

FCHO2² FCHO1²

2 SIMAP similar genes for SGIP1 using alignment to 5 protein entries: SGIP1_HUMAN (see all proteins):

FCHO2 FCHO1

SGIP1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: SGIP1_HUMAN, Q9BQI5

Polymorphism: Genetic variation in SGIP1 is associated with fat mass and SGIP1 may be a determinant of obesity-related

traits

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12058383^1,2	F,	--	66997893(+)	`TCATTC/ACCCTT`	1	--	us2k¹ trp³		1		WA	118
rs6699568^1,2	C,F,A,	--	66997958(+)	`CCCTGA/GAGAAT`	1	--	us2k¹		9		NA WA EA	386
rs4142763^1,2	C,F,A,H,	--	66998036(+)	`TCTAAG/ATTGCT`	1	--	us2k¹		21		NA NS EA WA CSA	935
rs78473006^1,2		--	66998099(+)	`CAGTAC/TGTCAT`	1	--	us2k¹		2		CSA WA	119
rs149883736^1,2		--	66998245(+)	`TATTTC/TGAGTA`	1	--	us2k¹		0	--	--	--	--
rs182543953^1,2		--	66998275(+)	`CAATTG/TCTCTC`	1	--	us2k¹		0	--	--	--	--
rs7544247^1,2	C,F,A,	--	66998351(+)	`GTTGTT/CTTTCC`	1	--	us2k¹		8		NA WA EA	504
rs186864385^1,2		--	66998427(+)	`CATAGA/GCTGCC`	1	--	us2k¹		0	--	--	--	--
rs7532400^1,2	C,F,H,	--	66998436(+)	`CCCTGC/ACCTTT`	1	--	us2k¹ trp³		20		NS EA NA WA	2360
rs114446161^1,2		--	66998484(+)	`AGGGTC/TGTAGA`	1	--	us2k¹		1		NA	120

HapMap Linkage Disequilibrium report for SGIP1 (66999066 - 67213982 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for SGIP1
2 CNVs: 97381 5500
5 Indels: 39612 60834 39613 44610 42275

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SGIP1

DNA2.0 Custom Variant and Variant Library Synthesis for SGIP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SGIP1 for disorders           About GeneDecksing

OMIM gene information: 611540    OMIM disorders: --

2 diseases for SGIP1:    About MalaCards

neuronitis obesity

Human Genome Epidemiology (HuGE) Navigator: SGIP1 (5 documents)

Export disorders for SGIP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SGIP1 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with SGIP1)

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Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2, 3} Wiemann S.... Poustka A. (2001)
Genetic variation in SH3-domain GRB2-like (endophilin)-interacting protein 1 has a major impact on fat mass. (PubMed id 21407171)^{1, 2} Cummings N.... Jowett J.B. (2012)
Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits. (PubMed id 20946875)^{1, 2} Dergai O....Rynditch A. (2010)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance. (PubMed id 15919751)^{1, 2} Trevaskis J.... Collier G.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Nonreplication of an association of SGIP1 SNPs with al cohol dependence and resting theta EEG power. (PubMed id 21317682)¹ Derringer J....Bierut L.J. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Genome-wide association identifies candidate genes th at influence the human electroencephalogram. (PubMed id 20421487)¹ Hodgkinson C.A....Goldman D. (2010)
Syp1 is a conserved endocytic adaptor that contains d omains involved in cargo selection and membrane tubulation. (PubMed id 19713939)¹ Reider A....Wendland B. (2009)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 84251	HGNC: 25412	AceView: DKFZp761D221	Ensembl:ENSG00000118473	euGenes: HUgn84251
ECgene: SGIP1	H-InvDB: SGIP1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SGIP1	Pharmacogenomics, SNPs, Pathways

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SH3-domain GRB2-like (endophilin) interacting protein 1

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SH3-domain GRB2-like (endophilin) interacting protein 1

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