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Aliases for SGF29 Gene

Aliases for SGF29 Gene

  • SAGA Complex Associated Factor 29 2 3 5
  • Coiled-Coil Domain-Containing Protein 101 3 4
  • Coiled-Coil Domain Containing 101 2 3
  • CCDC101 3 4
  • SAGA-Associated Factor 29 Homolog (Yeast) 2
  • SAGA-Associated Factor 29 Homolog 3
  • SAGA Complex-Associated Factor 29 4
  • SAGA-Associated Factor 29 3
  • STAF36 3
  • TDRD29 3

External Ids for SGF29 Gene

Previous HGNC Symbols for SGF29 Gene

  • CCDC101

Summaries for SGF29 Gene

Entrez Gene Summary for SGF29 Gene

  • CCDC101 is a subunit of 2 histone acetyltransferase complexes: the ADA2A (TADA2A; MIM 602276)-containing (ATAC) complex and the SPT3 (SUPT3H; MIM 602947)-TAF9 (MIM 600822)-GCN5 (KAT2A; MIM 602301)/PCAF (KAT2B; MIM 602303) acetylase (STAGA) complex. Both of these complexes contain either GCN5 or PCAF, which are paralogous acetyltransferases (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010]

GeneCards Summary for SGF29 Gene

SGF29 (SAGA Complex Associated Factor 29) is a Protein Coding gene. Diseases associated with SGF29 include Granulomatous Hepatitis. Among its related pathways are Chromatin organization. An important paralog of this gene is LOC388242.

UniProtKB/Swiss-Prot for SGF29 Gene

  • Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated Lys-4 of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA-type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGF29 Gene

Genomics for SGF29 Gene

Regulatory Elements for SGF29 Gene

Enhancers for SGF29 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G028542 1.7 FANTOM5 Ensembl ENCODE 11.2 -10.4 -10352 1.9 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SULT1A2 TUFM NFATC2IP ENSG00000260853 NPIPB7 CLN3 APOBR SGF29 EIF3CL ENSG00000260367
GH16G028595 1.5 Ensembl ENCODE dbSUPER 12.2 +43.4 43399 3.0 PKNOX1 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 ZNF2 ZNF766 ZNF143 SULT1A2 TUFM SGF29 ENSG00000278665
GH16G028531 1.5 FANTOM5 Ensembl ENCODE 12.1 -20.3 -20260 3.7 ELF3 CBX3 ARID4B RAD21 RARA YY1 ZNF121 ZNF366 IKZF2 MIXL1 SULT1A2 TUFM APOBR SGF29 NPIPB7 CLN3 IL27 ENSG00000251417 SULT1A1 SPNS1
GH16G028525 1.1 ENCODE 12.1 -26.5 -26496 3.8 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 ZNF766 KLF13 SP3 SP5 SULT1A2 TUFM CLN3 APOBR NPIPB7 SGF29 ENSG00000251417 IL27 PIR42560
GH16G028950 1.1 ENCODE 12 +397.4 397405 2.4 HDGF PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF143 FOS SULT1A2 SMG1P2 SGF29 NFATC2IP EIF3CL KCTD13 TMEM219 MIR4517
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SGF29 on UCSC Golden Path with GeneCards custom track

Promoters for SGF29 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000084908 85 1201 HDGF PKNOX1 MLX CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for SGF29 Gene

Chromosome:
16
Start:
28,553,915 bp from pter
End:
28,591,790 bp from pter
Size:
37,876 bases
Orientation:
Plus strand

Genomic View for SGF29 Gene

Genes around SGF29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGF29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGF29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGF29 Gene

Proteins for SGF29 Gene

  • Protein details for SGF29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96ES7-SGF29_HUMAN
    Recommended name:
    SAGA-associated factor 29
    Protein Accession:
    Q96ES7
    Secondary Accessions:
    • Q96MF5

    Protein attributes for SGF29 Gene

    Size:
    293 amino acids
    Molecular mass:
    33238 Da
    Quaternary structure:
    • Interacts with TADA3L, GCN5L2, SUPT3H and MYC (By similarity). Component of some SAGA-type complexes. Interacts with dimethylated and trimethylated Lys-4 of histone H3 (H3K4me2 and H3K4me3), with a preference for the trimethylated form (H3K4me3). Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.

    Three dimensional structures from OCA and Proteopedia for SGF29 Gene

neXtProt entry for SGF29 Gene

Post-translational modifications for SGF29 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SGF29 Gene

No data available for DME Specific Peptides for SGF29 Gene

Domains & Families for SGF29 Gene

Protein Domains for SGF29 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SGF29 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96ES7

UniProtKB/Swiss-Prot:

SGF29_HUMAN :
  • The SGF29 tudor-like domain mediates binding to methylated Lys-4 of histone H3 (H3K4me).
  • Belongs to the SGF29 family.
Domain:
  • The SGF29 tudor-like domain mediates binding to methylated Lys-4 of histone H3 (H3K4me).
Family:
  • Belongs to the SGF29 family.
genes like me logo Genes that share domains with SGF29: view

Function for SGF29 Gene

Molecular function for SGF29 Gene

UniProtKB/Swiss-Prot Function:
Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated Lys-4 of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA-type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation.

Gene Ontology (GO) - Molecular Function for SGF29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0035064 methylated histone binding IDA 20850016
genes like me logo Genes that share ontologies with SGF29: view
genes like me logo Genes that share phenotypes with SGF29: view

Animal Models for SGF29 Gene

MGI Knock Outs for SGF29:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SGF29

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SGF29 Gene

Localization for SGF29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SGF29 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SGF29 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SGF29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IDA 18838386
GO:0070461 SAGA-type complex IDA 18838386
genes like me logo Genes that share ontologies with SGF29: view

Pathways & Interactions for SGF29 Gene

genes like me logo Genes that share pathways with SGF29: view

Pathways by source for SGF29 Gene

Interacting Proteins for SGF29 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000316114%0d%0a9606.ENSP00000307684%0d%0a9606.ENSP00000308022%0d%0a9606.ENSP00000263754%0d%0a9606.ENSP00000225916%0d%0a9606.ENSP00000360515%0d%0a
Selected Interacting proteins: ENSP00000316114 Q96ES7-SGF29_HUMAN for SGF29 Gene via STRING MINT IID UniProtKB

Symbol External ID(s) Details
HIST1H3H
HIST1H3J
HIST1H3A
HIST1H3B
HIST1H3C

Gene Ontology (GO) - Biological Process for SGF29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016569 covalent chromatin modification IEA --
GO:0043966 histone H3 acetylation IDA 18838386
GO:0071169 establishment of protein localization to chromatin TAS 20850016
genes like me logo Genes that share ontologies with SGF29: view

No data available for SIGNOR curated interactions for SGF29 Gene

Drugs & Compounds for SGF29 Gene

No Compound Related Data Available

Transcripts for SGF29 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SGF29

Alternative Splicing Database (ASD) splice patterns (SP) for SGF29 Gene

No ASD Table

Relevant External Links for SGF29 Gene

GeneLoc Exon Structure for
SGF29
ECgene alternative splicing isoforms for
SGF29

Expression for SGF29 Gene

NURSA nuclear receptor signaling pathways regulating expression of SGF29 Gene:

SGF29

Evidence on tissue expression from TISSUES for SGF29 Gene

  • Muscle(4.5)
  • Skin(2.1)
  • Lung(2)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SGF29 Gene

Orthologs for SGF29 Gene

This gene was present in the common ancestor of animals.

Orthologs for SGF29 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC101 34 35
  • 99.2 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 99 (a)
OneToMany
CCDC101 34
  • 92.61 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 97 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CCDC101 34
  • 93.06 (n)
-- 35
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ccdc101 34 35
  • 90.78 (n)
Sgf29 16
rat
(Rattus norvegicus)
Mammalia Ccdc101 34
  • 89.8 (n)
chicken
(Gallus gallus)
Aves CCDC101 34 35
  • 81 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 96 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc101 34
  • 81.34 (n)
Str.1997 34
zebrafish
(Danio rerio)
Actinopterygii ccdc101 34 35
  • 76.04 (n)
Dr.13656 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11051 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005116 34
  • 58.18 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sgf29 34 35
  • 54.74 (n)
worm
(Caenorhabditis elegans)
Secernentea Y17G9B.8 34 35
  • 47.12 (n)
T22B7.4 35
  • 14 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3192 34
Species where no ortholog for SGF29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SGF29 Gene

ENSEMBL:
Gene Tree for SGF29 (if available)
TreeFam:
Gene Tree for SGF29 (if available)

Paralogs for SGF29 Gene

Paralogs for SGF29 Gene

Pseudogenes.org Pseudogenes for SGF29 Gene

genes like me logo Genes that share paralogs with SGF29: view

Variants for SGF29 Gene

Sequence variations from dbSNP and Humsavar for SGF29 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000042689 -- 28,558,302(+) GTAGA(A/G)ATGGG intron-variant
rs1000045131 -- 28,554,446(+) ATGGG(C/T)CCCGA intron-variant
rs1000149731 -- 28,561,128(+) GGCTC(A/C)CACCT intron-variant
rs1000152063 -- 28,588,439(+) TTTGC(C/T)GAAGG intron-variant
rs1000235224 -- 28,571,728(+) AAAAA(A/C)GTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SGF29 Gene

Variant ID Type Subtype PubMed ID
esv2758640 CNV gain+loss 17122850
esv3638337 CNV gain 21293372
esv3892823 CNV gain 25118596
nsv1059555 CNV gain 25217958
nsv1066415 CNV gain 25217958
nsv1138423 CNV deletion 24896259
nsv509608 CNV insertion 20534489
nsv833180 CNV loss 17160897
nsv833182 CNV gain 17160897
nsv9416 CNV gain+loss 18304495

Variation tolerance for SGF29 Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SGF29 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SGF29

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SGF29 Gene

Disorders for SGF29 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SGF29 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
granulomatous hepatitis
- elite association - COSMIC cancer census association via MalaCards
Search SGF29 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SGF29

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SGF29
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SGF29
genes like me logo Genes that share disorders with SGF29: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SGF29 Gene

Publications for SGF29 Gene

  1. Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. (PMID: 21685874) Bian C. … Min J. (EMBO J. 2011) 2 3 4 64
  2. Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. (PMID: 20850016) Vermeulen M. … Mann M. (Cell 2010) 3 4 64
  3. Deregulated expression of a novel component of TFTC/STAGA histone acetyltransferase complexes, rat SGF29, in hepatocellular carcinoma: possible implication for the oncogenic potential of c-Myc. (PMID: 17334388) Kurabe N. … Tashiro F. (Oncogene 2007) 2 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SGF29 Gene

  • Addgene plasmids for SGF29

Sources for SGF29 Gene

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