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Aliases for SGF29 Gene

Aliases for SGF29 Gene

  • SAGA Complex Associated Factor 29 2 3 5
  • Coiled-Coil Domain-Containing Protein 101 3 4
  • Coiled-Coil Domain Containing 101 2 3
  • SAGA Complex-Associated Factor 29 3 4
  • CCDC101 3 4
  • SAGA-Associated Factor 29 Homolog (Yeast) 2
  • SAGA-Associated Factor 29 Homolog 3
  • STAF36 3
  • TDRD29 3

External Ids for SGF29 Gene

Previous HGNC Symbols for SGF29 Gene

  • CCDC101

Summaries for SGF29 Gene

Entrez Gene Summary for SGF29 Gene

  • CCDC101 is a subunit of 2 histone acetyltransferase complexes: the ADA2A (TADA2A; MIM 602276)-containing (ATAC) complex and the SPT3 (SUPT3H; MIM 602947)-TAF9 (MIM 600822)-GCN5 (KAT2A; MIM 602301)/PCAF (KAT2B; MIM 602303) acetylase (STAGA) complex. Both of these complexes contain either GCN5 or PCAF, which are paralogous acetyltransferases (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010]

GeneCards Summary for SGF29 Gene

SGF29 (SAGA Complex Associated Factor 29) is a Protein Coding gene. Diseases associated with SGF29 include granulomatous hepatitis. Among its related pathways are Chromatin organization. An important paralog of this gene is LOC388242.

UniProtKB/Swiss-Prot for SGF29 Gene

  • Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated Lys-4 of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA-type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGF29 Gene

Genomics for SGF29 Gene

Regulatory Elements for SGF29 Gene

Enhancers for SGF29 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SGF29 on UCSC Golden Path with GeneCards custom track

Promoters for SGF29 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SGF29 on UCSC Golden Path with GeneCards custom track

Genomic Location for SGF29 Gene

Chromosome:
16
Start:
28,553,915 bp from pter
End:
28,591,790 bp from pter
Size:
37,876 bases
Orientation:
Plus strand

Genomic View for SGF29 Gene

Genes around SGF29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGF29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGF29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGF29 Gene

Proteins for SGF29 Gene

  • Protein details for SGF29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96ES7-SGF29_HUMAN
    Recommended name:
    SAGA-associated factor 29
    Protein Accession:
    Q96ES7
    Secondary Accessions:
    • Q96MF5

    Protein attributes for SGF29 Gene

    Size:
    293 amino acids
    Molecular mass:
    33238 Da
    Quaternary structure:
    • Interacts with TADA3L, GCN5L2, SUPT3H and MYC (By similarity). Component of some SAGA-type complexes. Interacts with dimethylated and trimethylated Lys-4 of histone H3 (H3K4me2 and H3K4me3), with a preference for the trimethylated form (H3K4me3). Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.

    Three dimensional structures from OCA and Proteopedia for SGF29 Gene

neXtProt entry for SGF29 Gene

Proteomics data for SGF29 Gene at MOPED

Post-translational modifications for SGF29 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SGF29 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SGF29 Gene

Domains & Families for SGF29 Gene

Protein Domains for SGF29 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SGF29 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96ES7

UniProtKB/Swiss-Prot:

SGF29_HUMAN :
  • The SGF29 tudor-like domain mediates binding to methylated Lys-4 of histone H3 (H3K4me).
  • Belongs to the SGF29 family.
Domain:
  • The SGF29 tudor-like domain mediates binding to methylated Lys-4 of histone H3 (H3K4me).
  • Contains 1 SGF29 C-terminal domain.
Family:
  • Belongs to the SGF29 family.
genes like me logo Genes that share domains with SGF29: view

Function for SGF29 Gene

Molecular function for SGF29 Gene

UniProtKB/Swiss-Prot Function:
Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated Lys-4 of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA-type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation.

Gene Ontology (GO) - Molecular Function for SGF29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0047485 protein N-terminus binding IEA --
genes like me logo Genes that share ontologies with SGF29: view
genes like me logo Genes that share phenotypes with SGF29: view

Animal Models for SGF29 Gene

MGI Knock Outs for SGF29:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SGF29 Gene

Localization for SGF29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SGF29 Gene

Gene Ontology (GO) - Cellular Components for SGF29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070461 SAGA-type complex IDA 18838386
genes like me logo Genes that share ontologies with SGF29: view

No data available for Subcellular locations from COMPARTMENTS for SGF29 Gene

Pathways & Interactions for SGF29 Gene

genes like me logo Genes that share pathways with SGF29: view

Pathways by source for SGF29 Gene

Interacting Proteins for SGF29 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000316114%0d%0a9606.ENSP00000307684%0d%0a9606.ENSP00000360515%0d%0a9606.ENSP00000252996%0d%0a9606.ENSP00000312709%0d%0a9606.ENSP00000336750%0d%0a
Selected Interacting proteins: Q96ES7-SGF29_HUMAN ENSP00000316114 for SGF29 Gene via UniProtKB I2D MINT STRING

Symbol External ID(s) Details
HIST1H3J
HIST1H3A
HIST1H3B
HIST1H3C
HIST1H3D

Gene Ontology (GO) - Biological Process for SGF29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0043966 histone H3 acetylation IDA 18838386
genes like me logo Genes that share ontologies with SGF29: view

No data available for SIGNOR curated interactions for SGF29 Gene

Drugs & Compounds for SGF29 Gene

No Compound Related Data Available

Transcripts for SGF29 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for SGF29 Gene

No ASD Table

Relevant External Links for SGF29 Gene

GeneLoc Exon Structure for
SGF29
ECgene alternative splicing isoforms for
SGF29

Expression for SGF29 Gene

No Expression Related Data Available

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SGF29 Gene

Orthologs for SGF29 Gene

This gene was present in the common ancestor of animals.

Orthologs for SGF29 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Sgf29 16
Ccdc101 36
  • 98 (a)
OneToMany
Ccdc101 35
  • 90.78 (n)
  • 98.29 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 99 (a)
OneToMany
CCDC101 35
  • 92.61 (n)
  • 98.98 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 92 (a)
OneToMany
CCDC101 35
  • 93.06 (n)
  • 98.98 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 97 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 97 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CCDC101 36
  • 100 (a)
OneToOne
CCDC101 35
  • 99.2 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Ccdc101 35
  • 89.8 (n)
  • 98.43 (a)
chicken
(Gallus gallus)
Aves CCDC101 36
  • 95 (a)
OneToMany
CCDC101 35
  • 81 (n)
  • 94.54 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 96 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1997 35
ccdc101 35
  • 81.34 (n)
  • 95.56 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.13656 35
ccdc101 36
  • 91 (a)
OneToMany
ccdc101 35
  • 76.04 (n)
  • 90.76 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11051 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005116 35
  • 58.18 (n)
  • 54.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sgf29 35
  • 54.74 (n)
  • 52.4 (a)
Sgf29 36
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T22B7.4 36
  • 14 (a)
ManyToMany
Y17G9B.8 36
  • 35 (a)
ManyToMany
Y17G9B.8 35
  • 47.12 (n)
  • 41.83 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3192 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
Species with no ortholog for SGF29:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SGF29 Gene

ENSEMBL:
Gene Tree for SGF29 (if available)
TreeFam:
Gene Tree for SGF29 (if available)

Paralogs for SGF29 Gene

Paralogs for SGF29 Gene

Pseudogenes.org Pseudogenes for SGF29 Gene

genes like me logo Genes that share paralogs with SGF29: view

Variants for SGF29 Gene

Variation tolerance for SGF29 Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SGF29 Gene

HapMap Linkage Disequilibrium report
SGF29

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for SGF29 Gene

Disorders for SGF29 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SGF29 Gene - From: DISEASES

Disorder Aliases PubMed IDs
granulomatous hepatitis
- elite association - COSMIC cancer census association via MalaCards
Search SGF29 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SGF29

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SGF29
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SGF29
genes like me logo Genes that share disorders with SGF29: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SGF29 Gene

Publications for SGF29 Gene

  1. Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. (PMID: 21685874) Bian C. … Min J. (EMBO J. 2011) 2 3 4 67
  2. Deregulated expression of a novel component of TFTC/STAGA histone acetyltransferase complexes, rat SGF29, in hepatocellular carcinoma: possible implication for the oncogenic potential of c-Myc. (PMID: 17334388) Kurabe N. … Tashiro F. (Oncogene 2007) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for SGF29 Gene

Sources for SGF29 Gene

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