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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SGCG Gene

protein-coding   GIFtS: 60
GCID: GC13P023755

Sarcoglycan, Gamma (35kDa Dystrophin-Associated Glycoprotein)

(Previous names: sarcoglycan, gamma (35kD dystrophin-associated glycoprotein))
(Previous symbols: DMDA1, MAM, LGMD2C)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sarcoglycan, Gamma (35kDa Dystrophin-Associated Glycoprotein)1 2     Maghrebian Myopathy (Autosomal Recessive)1
DMDA11 2 5     Sarcoglycan, Gamma (35kD Dystrophin-Associated Glycoprotein)1
LGMD2C1 2 5     A42
MAM1 2     DAGA42
35kD Dystrophin-Associated Glycoprotein1 2     DMDA2
Gamma Sarcoglycan1 2     SCARMD22
35 KDa Dystrophin-Associated Glycoprotein2 3     TYPE2
35DAG2 3     gamma-SG2
SCG32 5     gamma-sarcoglycan2
Autosomal Recessive)1     Gamma-SG3
Limb Girdle Muscular Dystrophy 2C (Duchenne-Like Muscular Dystrophy1     

External Ids:    HGNC: 108091   Entrez Gene: 64452   Ensembl: ENSG000001026837   OMIM: 6088965   UniProtKB: Q133263   

Export aliases for SGCG gene to outside databases

Previous GC identifers: GC13P021735 GC13P017735 GC13P022685 GC13P021553 GC13P022653 GC13P004568


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SGCG Gene:
This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with
dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin,
syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the
subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead
to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C
(LGMD2C). (provided by RefSeq, Oct 2008)

GeneCards Summary for SGCG Gene: 
SGCG (sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)) is a protein-coding gene. Diseases associated with SGCG include limb-girdle muscular dystrophy, type 2c, and sarcoglycanopathies, and among its related super-pathways are Hypertrophic cardiomyopathy (HCM) and Allograft rejection. An important paralog of this gene is SGCD.

UniProtKB/Swiss-Prot: SGCG_HUMAN, Q13326
Function: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a
link between the F-actin cytoskeleton and the extracellular matrix

Gene Wiki entry for SGCG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SGCG gene promoter:
         PPAR-alpha   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSGCG promoter sequence
   Search SABiosciences Chromatin IP Primers for SGCG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SGCG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12   Ensembl cytogenetic band:  13q12.12   HGNC cytogenetic band: 13q12-q13

SGCG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SGCG gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P023755:  view genomic region     (about GC identifiers)

Start:
23,755,060 bp from pter      End:
23,899,304 bp from pter
Size:
144,245 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SGCG_HUMAN, Q13326 (See protein sequence)
Recommended Name: Gamma-sarcoglycan  
Size: 291 amino acids; 32379 Da
Subunit: Interacts with the syntrophin SNTA1. Cross-link to form 2 major subcomplexes: one consisting of SGCB,
SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly
strong while SGCA is loosely associated with the other sarcoglycans (By similarity). Interacts with FLNC
Subcellular location: Cell membrane, sarcolemma; Single-pass type II membrane protein (By similarity). Cytoplasm,
cytoskeleton (By similarity)
Secondary accessions: Q32M32 Q5T9J6

Explore the universe of human proteins at neXtProt for SGCG: NX_Q13326

Explore proteomics data for SGCG at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13326

  • SGCG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SGCG Protein Expression
    REFSEQ proteins: NP_000222.1  
    ENSEMBL proteins: 
     ENSP00000218867   ENSP00000444100   ENSP00000442232  

    Human Recombinant Protein Products for SGCG: 
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    Novus Biologicals SGCG Lysates
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0005886plasma membrane TAS8641426
    GO:0016012sarcoglycan complex IEA--
    GO:0016021integral to membrane IEA--

    SGCG for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR006875 Sarcoglycan

    Graphical View of Domain Structure for InterPro Entry Q13326

    ProtoNet protein and cluster: Q13326

    1 Blocks protein domain: IPB006875 Sarcoglycan complex subunit protein

    UniProtKB/Swiss-Prot: SGCG_HUMAN, Q13326
    Similarity: Belongs to the sarcoglycan beta/delta/gamma/zeta family


    SGCG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SGCG_HUMAN, Q13326
    Function: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a
    link between the F-actin cytoskeleton and the extracellular matrix

         Genatlas biochemistry entry for SGCG:
    sarcoglycan gamma,dystrophin associated protein A4 (35kDa),expressed in skeletal and cardiac muscle,associating
    with other sarcoglycans and in a stoichiometrically equal complex,stabilizing the link between dystroglycan and
    dystrophin/utrophin

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    SGCG for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sgcg):
     behavior/neurological  cardiovascular system  cellular  growth/size  homeostasis/metabolism 
     mortality/aging  muscle  skeleton 

    SGCG for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SGCG: Sgcgtm1Oza Sgcgtm1Mcn

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SGCG 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SGCG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SGCG 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SGCG 

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    1 QIAGEN miScript miRNA Assays for microRNA that regulate SGCG:
    hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmidSGCG 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGCG


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SGCG About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.53
    2Allograft rejection
    Viral myocarditis0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SGCG
        Arrhythmogenic right ventricular cardiomyopathy


    4         Kegg Pathways  (Kegg details for SGCG):
        Hypertrophic cardiomyopathy (HCM)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    Dilated cardiomyopathy
    Viral myocarditis


    SGCG for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SGCG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/27 Interacting proteins for SGCG (Q133261, 2, 3 ENSP000002188674) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FLNCQ143152, 3, ENSP000003271454MINT-15713 MINT-15712 MINT-15714 I2D: score=4 STRING: ENSP00000327145
    SGCDQ926293, ENSP000003383434I2D: score=3 STRING: ENSP00000338343
    CDK8P493363, ENSP000003709384I2D: score=1 STRING: ENSP00000370938
    DMDP115323, ENSP000003549234I2D: score=1 STRING: ENSP00000354923
    SGCZQ96LD13, ENSP000003715124I2D: score=1 STRING: ENSP00000371512
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization ----
    GO:0007517muscle organ development TAS8641426

    SGCG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SGCG

    Search CenterWatch for drugs/clinical trials and news about SGCG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SGCG gene: 
    NM_000231.2  

    Unigene Cluster for SGCG:

    Sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
    Hs.37167  [show with all ESTs]
    Unigene Representative Sequence: NM_000231
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000218867(uc001uom.2 uc009zzv.2 uc009zzw.2) ENST00000537476
    ENST00000545013
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate SGCG:
    hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmidSGCG 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SGCG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGCG
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    Additional mRNA sequence: 

    AK290620.1 AK316579.1 BC074777.2 BC074778.2 BC109321.2 U34976.1 

    3 DOTS entries:

    DT.402122  DT.120783184  DT.120783180 

    11 AceView cDNA sequences:

    U34976 AI276563 BC074778 BG201553 NM_000231 BC074777 AI127453 AI370490 
    BX098887 AJ710063 C03544 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SGCG expression in normal human tissues (normalized intensities)      SGCG embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCTCAAAAT
    SGCG Expression
    About this image


    SGCG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Lung (Respiratory System)
     
     Heart (Cardiovascular System)

    See SGCG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SGCG

    SOURCE GeneReport for Unigene cluster: Hs.37167

    UniProtKB/Swiss-Prot: SGCG_HUMAN, Q13326
    Tissue specificity: Expressed in skeletal and heart muscle

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SGCG gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sgcg1 , 5 sarcoglycan, gamma (dystrophin-associated glycoprotein)1, 5 82.59(n)1
    83.85(a)1
      14 (32.27 cM)5
    240531  NM_011892.31  NP_036022.11 
     612210595 
    chicken
    (Gallus gallus)
    Aves SGCG1 sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 77.59(n)
    83.1(a)
      418945  XM_417139.3  XP_417139.2 
    lizard
    (Anolis carolinensis)
    Reptilia SGCG6
    sarcoglycan, gamma (35kDa dystrophin-associated gl...
    57(a)
    1 ↔ 1
    3(188567258-188596287)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.151702 Transcribed sequence with moderate similarity to protein more 76.61(n)    AL900078.2 
    zebrafish
    (Danio rerio)
    Actinopterygii sgcg1 sarcoglycan, gamma 62.92(n)
    64.21(a)
      445292  NM_001003748.1  NP_001003748.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Scg&dgr;3 cytoskeletal anchoring cytoskeletal
    anchor protein
    38(a)   2B8   --
    worm
    (Caenorhabditis elegans)
    Secernentea sgn-13 gamma-sarcoglycan 35(a)   II(8781992-8783467)   --


    ENSEMBL Gene Tree for SGCG (if available)
    TreeFam Gene Tree for SGCG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SGCG gene
    SGCD2  SGCZ2  
    2 SIMAP similar genes for SGCG using alignment to 1 protein entry:     SGCG_HUMAN:
    SGCD    SGCZ

    SGCG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3815 SNPs in SGCG are shown (see all 3815)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0104304
    Limb-girdle muscular dystrophy 2C (LGMD2C)4--see VAR_0104302 G D mis40--------
    VAR_0103984
    Limb-girdle muscular dystrophy 2C (LGMD2C)4--see VAR_0103982 C Y mis40--------
    VAR_0122024
    Limb-girdle muscular dystrophy 2C (LGMD2C)4--see VAR_0122022 G R mis40--------
    rs1048944231,2
    Cpathogenic14853198(+) TCTACA/GAAATC 2 K E mis10--------
    rs1048944221,2
    Cpathogenic14853259(+) CACGTA/GCCAGG 2 Y C mis10--------
    VAR_0103994
    ----see VAR_0103992 N S mis40--------
    rs30649531,2
    C--4581078(-) tctctCTCT/-  
            
    gccac
    1 -- int11Minor allele frequency- -:0.00CSA 2
    rs671882991,2
    C--4581079(+) TGGCA-/AGAG  
            
    GAGAG
    1 -- int10--------
    rs1498182081,2
    C--4583228(+) CTAGA-/TGTGTGT 1 -- int10--------
    rs680335261,2
    C--4587294(+) ACTTA-/CAAAAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for SGCG (23755060 - 23899304 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/20 variations for SGCG (see all 20):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2747128CNV Deletion23290073
    esv2747122CNV Deletion23290073
    esv2422502CNV Duplication17116639
    esv2422437CNV Duplication17116639
    esv22115CNV Loss19812545
    nsv471123CNV Loss18288195
    nsv520725CNV Loss19592680
    esv2751136CNV Loss17911159
    nsv517054CNV Loss19592680
    nsv455838CNV Gain19166990


    Human Gene Mutation Database (HGMD): SGCG

    Locus Specific Mutation Databases (LSDB): SGCG
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SGCG
    DNA2.0 Custom Variant and Variant Library Synthesis for SGCG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608896   
    OMIM disorders: 253700  
    UniProtKB/Swiss-Prot: SGCG_HUMAN, Q13326
  • Limb-girdle muscular dystrophy 2C (LGMD2C) [MIM:253700]: An autosomal recessive degenerative myopathy
    characterized by rapidly progressive muscle wasting from early childhood with loss of independent ambulation
    around age 12 years, dystrophic pattern on muscle biopsy, absence of gamma-sarcoglycan and normal dystrophin
    immunostaining. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20 diseases for SGCG:    About MalaCards
    limb-girdle muscular dystrophy, type 2c    sarcoglycanopathies    limb-girdle muscular dystrophy    vacterl association
    bovine spongiform encephalopathy    imperforate anus    muscular dystrophy    esophageal atresia
    gastroenteritis    neurofibromatosis    myocarditis    hypertrophic cardiomyopathy
    spasticity    bipolar disorder    dilated cardiomyopathy    ataxia
    myopathy    neuropathy    esophagitis    alcoholism

    2 diseases from the University of Copenhagen DISEASES database for SGCG:
    Myopathy     Neuropathy

    SGCG for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for SGCG gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lgmd2f 94.2 2 9266733 (1), 10196712 (1)
    limb girdle 84.7 1 11856878 (1)
    muscular dystrophies 81.2 2 8173351 (1), 11856878 (1)
    lgmd2a 78.4 1 9266733 (1)

    Genetic Association Database (GAD): SGCG
    Human Genome Epidemiology (HuGE) Navigator: SGCG (3 documents)

    Export disorders for SGCG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SGCG gene, integrated from 9 sources (see all 57):
    (articles sorted by number of sources associating them with SGCG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A founder mutation in the gamma-sarcoglycan gene of Gypsies possibly predating their migration out of India. (PubMed id 8968757)1, 2, 3, 9 Piccolo F.... Kaplan J.-C. (1996)
    2. Genome-wide significant association between alcohol de pendence and a variant in the ADH gene cluster. (PubMed id 22004471)1, 4 Frank J....Rietschel M. (2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. C283Y gamma-sarcoglycan gene mutation in the Bulgarian Roma (Gypsy) population: prevalence study and carrier screening in a high-risk community. (PubMed id 15479193)1, 4 Georgieva B....Kremensky I. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Screening for C283Y gamma-sarcoglycan mutation in a high-risk group of Bulgarian Gypsies: evidence for a geographical localization and a non-random distribution among Gypsy subgroups. (PubMed id 14960875)1, 4 Todorova A....Kremensky I. (2002)
    7. Filamin 2 (FLN2): a muscle-specific sarcoglycan interacting protein. (PubMed id 10629222)1, 2 Thompson T.G.... Kunkel L.M. (2000)
    8. Severe gamma-sarcoglycanopathy caused by a novel missense mutation and a large deletion. (PubMed id 10714584)1, 2 Nowak K.J.... Laing N.G. (2000)
    9. Mild and severe muscular dystrophy caused by a single gamma- sarcoglycan mutation. (PubMed id 8900232)1, 2 McNally E.M.... Kunkel L.M. (1996)
    10. Mutations in the dystrophin-associated protein gamma-sarcoglycan in chromosome 13 muscular dystrophy. (PubMed id 7481775)1, 2 Noguchi S.... Ozawa E. (1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6445 HGNC: 10809 AceView: SGCG Ensembl:ENSG00000102683 euGenes: HUgn6445
    ECgene: SGCG Kegg: 6445 H-InvDB: SGCG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SGCG Pharmacogenomics, SNPs, Pathways
    LEIDEN Muscular Dystrophy page for SGCG Scientfic Information about Duchenne and Duchenne-like muscular dystrophies.
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SGCG

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SGCG gene:
    Search GeneIP for patents involving SGCG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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