SGCG Gene

Aliases
for SGCG gene

Previous GC identifers: GC13P021735 GC13P017735 GC13P022685 GC13P021553 GC13P022653 GC13P004568

Summaries
for SGCG gene

Genomic Views
for SGCG gene

RefSeq DNA sequence:

NC_000013.10  NC_018924.1  NT_024524.14  

SwitchGear Promoter luciferase reporter plasmid: SGCG promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SGCG

SGCG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P023755:  view genomic region     (about GC identifiers)

Proteins
for SGCG gene

Explore the universe of human proteins at neXtProt for SGCG: NX_Q13326

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: SGCG OriGene Protein Over-expression Lysate: SGCG OriGene Custom Protein Services for SGCG
	GenScript Custom Purified and Recombinant Proteins Services for SGCG
	Novus Biologicals SGCG Proteins Novus Biologicals SGCG Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SGCG

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Browse OriGene Antibodies OriGene Custom Antibody Services for SGCG
	GenScript Custom Superior Antibodies Services for SGCG
	Novus Biologicals SGCG Antibodies
	Search for Antibodies for SGCG at Abcam
	Uscn Antibodies for SGCG
	Search ThermoFisher Antibodies for SGCG

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SGCG
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SGCG

Protein Domains /
Families
for SGCG gene

ProtoNet protein and cluster: Q13326

Function
for SGCG gene

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SGCG
		1 QIAGEN miScript miRNA Assays for microRNA that regulate SGCG:
		hsa-miR-137
		SwitchGear 3'UTR luciferase reporter plasmid: SGCG 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SGCG (see all 7) OriGene shRNA RFP: SGCG OriGene siRNA: SGCG
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SGCG

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for SGCG

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SGCG (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SGCG OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SGCG (NM_000231)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SGCG
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGCG

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SGCG
		Search LifeMap BioReagents cell lines for SGCG

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGCG

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Sgcg)

Pathways & Interactions
for SGCG gene

	Super-pathway	contained gene-specific pathways
1	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	Arrhythmogenic right ventricular cardiomyopathy (ARVC) 1.00 Arrhythmogenic right ventricular cardiomyopathy 0.99
2	Hypertrophic cardiomyopathy (HCM)	Hypertrophic cardiomyopathy (HCM) 1.00 Dilated cardiomyopathy 0.75
3	Allograft rejection	Viral myocarditis 0.33

1 BioSystems Pathway for SGCG

Arrhythmogenic right ventricular cardiomyopathy

4         Kegg Pathways  (Kegg details for SGCG)

	Hypertrophic cardiomyopathy (HCM)
	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
	Dilated cardiomyopathy
	Viral myocarditis

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for SGCG gene

Transcripts
for SGCG gene

Expression
for SGCG gene

SGCG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCTCAAAAT

2 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	KidneyCap MesenchymeCap Mesenchyme Cells			Kidney
	BoneMandibular Process			Bone
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SGCG Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SGCG
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SGCG
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SGCG

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGCG

Orthologs
for SGCG gene

Paralogs
for SGCG gene

Paralogs for SGCG gene

SGCD²  SGCZ²  

2 SIMAP similar genes for SGCG using alignment to 1 protein entry:     SGCG_HUMAN:

SGCD    SGCZ

SGCG for paralogs           About GeneDecksing

Genomic Variants
for SGCG gene

10/3352 NCBI SNPs in SGCG are shown (see all 3352)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1048944231,2	C	pathogenic	4711220(+)	TCTACA/GAAATC	2	K E	mis1		0	--	--	--	--
rs1048944221,2	C	pathogenic	4711281(+)	CACGTA/GCCAGG	2	Y C	mis1		0	--	--	--	--
rs170783961,2	C,F,H,	--	4567207(+)	AAAGTA/GGAAGT	1	--	us2k1		19		NA NS EA WA	1854
rs121001511,2	C,F,H,	--	4567226(+)	GCAGAG/TAATTC	1	--	us2k1		13		NS EA NA WA	1350
rs1122993341,2		--	4567507(+)	ATTGCG/ATATCA	1	--	us2k1		1		CSA	2
rs73200811,2	C,F,A,H,	--	4567808(+)	TTTATT/CCTGTT	1	--	us2k1		15		NS EA NA CSA WA	1626
rs790295581,2		--	4568858(+)	ACATAT/CTTTTA	1	--	int1		1		NA	120
rs760924761,2		--	4568916(+)	TAGCAT/GTTCTG	1	--	int1		2		CSA WA	120
rs744452851,2		--	4569768(+)	AAATTA/GCATTA	1	--	int1		0	--	--	--	--
rs731686211,2	C,	--	4569910(+)	AGGCAC/TCAGGG	1	--	int1		0	--	--	--	--

HapMap Linkage Disequilibrium report for SGCG (23755060 - 23899304 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for SGCG
     6 CNVs: 71691 5314 8746 5317 49189 9216
Human Gene Mutation Database (HGMD): SGCG

Locus Specific Mutation Databases (LSDB): SGCG

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SGCG

DNA2.0 Custom Variant and Variant Library Synthesis for SGCG

Disorders / Diseases
for SGCG gene

15 diseases for SGCG

4 Novoseek disease relationships for SGCG gene    About this table

Publications
for SGCG gene

PubMed articles for SGCG gene, integrated from 9 sources (see all 54): (articles sorted by number of sources associating them with SGCG)

Utopia: connect your pdf to the dynamic world of online information

1. A founder mutation in the gamma-sarcoglycan gene of Gypsies possibly predating their migration out of India. (PubMed id 8968757)^{1, 2, 3, 9} Piccolo F.... Kaplan J.-C. (1996)
2. C283Y gamma-sarcoglycan gene mutation in the Bulgarian Roma (Gypsy) population: prevalence study and carrier screening in a high-risk community. (PubMed id 15479193)^{1, 4} Georgieva B....Kremensky I. (2004)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
4. Screening for C283Y gamma-sarcoglycan mutation in a high-risk group of Bulgarian Gypsies: evidence for a geographical localization and a non-random distribution among Gypsy subgroups. (PubMed id 14960875)^{1, 4} Todorova A....Kremensky I. (2002)
5. Filamin 2 (FLN2): a muscle-specific sarcoglycan interacting protein. (PubMed id 10629222)^{1, 2} Thompson T.G.... Kunkel L.M. (2000)
6. Severe gamma-sarcoglycanopathy caused by a novel missense mutation and a large deletion. (PubMed id 10714584)^{1, 2} Nowak K.J.... Laing N.G. (2000)
7. Mild and severe muscular dystrophy caused by a single gamma- sarcoglycan mutation. (PubMed id 8900232)^{1, 2} McNally E.M.... Kunkel L.M. (1996)
8. Mutations in the dystrophin-associated protein gamma-sarcoglycan in chromosome 13 muscular dystrophy. (PubMed id 7481775)^{1, 2} Noguchi S.... Ozawa E. (1995)
9. Spectrum of mutations in sarcoglycan genes in the Mum bai region of western India: high prevalence of 525del T. (PubMed id 19770540)^{1, 9} Khadilkar S.V....Chong B. (2009)
10. Low incidence of limb-girdle muscular dystrophy type 2C revealed by a mutation study in Japanese patients clinically diagnosed with DMD. (PubMed id 20350330)^{1, 9} Okizuka Y....Matsuo M. (2010)

External Searches for SGCG gene

Genome Databases showing SGCG gene

Other Databases showing SGCG gene

Specialized Databases showing SGCG gene

Products
for SGCG gene