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Aliases for SGCG Gene

Aliases for SGCG Gene

  • Sarcoglycan Gamma 2 3 5
  • Sarcoglycan, Gamma (35kDa Dystrophin-Associated Glycoprotein) 2 3
  • 35 KDa Dystrophin-Associated Glycoprotein 3 4
  • 35kD Dystrophin-Associated Glycoprotein 2 3
  • Gamma-SG 3 4
  • 35DAG 3 4
  • Limb Girdle Muscular Dystrophy 2C (Duchenne-Like Muscular Dystrophy 2
  • Maghrebian Myopathy (Autosomal Recessive) 2
  • Autosomal Recessive) 2
  • Gamma Sarcoglycan 2
  • SCARMD2 3
  • LGMD2C 3
  • DAGA4 3
  • DMDA1 3
  • DMDA 3
  • SCG3 3
  • MAM 3
  • A4 3

External Ids for SGCG Gene

Previous HGNC Symbols for SGCG Gene

  • DMDA1
  • MAM
  • LGMD2C

Previous GeneCards Identifiers for SGCG Gene

  • GC13P021735
  • GC13P017735
  • GC13P022685
  • GC13P021553
  • GC13P022653
  • GC13P023755
  • GC13P004568

Summaries for SGCG Gene

Entrez Gene Summary for SGCG Gene

  • This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C). [provided by RefSeq, Oct 2008]

GeneCards Summary for SGCG Gene

SGCG (Sarcoglycan Gamma) is a Protein Coding gene. Diseases associated with SGCG include Muscular Dystrophy, Limb-Girdle, Type 2C and Limb-Girdle Muscular Dystrophy. Among its related pathways are Allograft rejection and Hypertrophic cardiomyopathy (HCM). An important paralog of this gene is SGCD.

UniProtKB/Swiss-Prot for SGCG Gene

  • Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

Gene Wiki entry for SGCG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGCG Gene

Genomics for SGCG Gene

Regulatory Elements for SGCG Gene

Enhancers for SGCG Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SGCG on UCSC Golden Path with GeneCards custom track

Genomic Location for SGCG Gene

23,160,506 bp from pter
23,325,165 bp from pter
164,660 bases
Plus strand

Genomic View for SGCG Gene

Genes around SGCG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGCG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGCG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGCG Gene

Proteins for SGCG Gene

  • Protein details for SGCG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q32M32
    • Q5T9J6

    Protein attributes for SGCG Gene

    291 amino acids
    Molecular mass:
    32379 Da
    Quaternary structure:
    • Interacts with the syntrophin SNTA1. Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans (By similarity). Interacts with FLNC.

neXtProt entry for SGCG Gene

Proteomics data for SGCG Gene at MOPED

Post-translational modifications for SGCG Gene

  • Glycosylation at Asn 110
  • Modification sites at PhosphoSitePlus

Other Protein References for SGCG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SGCG Gene

Domains & Families for SGCG Gene

Protein Domains for SGCG Gene

Suggested Antigen Peptide Sequences for SGCG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sarcoglycan beta/delta/gamma/zeta family.
  • Belongs to the sarcoglycan beta/delta/gamma/zeta family.
genes like me logo Genes that share domains with SGCG: view

No data available for Gene Families for SGCG Gene

Function for SGCG Gene

Molecular function for SGCG Gene

GENATLAS Biochemistry:
sarcoglycan gamma,dystrophin associated protein A4 (35kDa),expressed in skeletal and cardiac muscle,associating with other sarcoglycans and in a stoichiometrically equal complex,stabilizing the link between dystroglycan and dystrophin/utrophin
UniProtKB/Swiss-Prot Function:
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
genes like me logo Genes that share phenotypes with SGCG: view

Human Phenotype Ontology for SGCG Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SGCG Gene

MGI Knock Outs for SGCG:

Animal Model Products

miRNA for SGCG Gene

miRTarBase miRNAs that target SGCG

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for SGCG Gene

Localization for SGCG Gene

Subcellular locations from UniProtKB/Swiss-Prot for SGCG Gene

Cell membrane, sarcolemma; Single-pass type II membrane protein. Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for SGCG Gene COMPARTMENTS Subcellular localization image for SGCG gene
Compartment Confidence
plasma membrane 5
cytoskeleton 4
extracellular 2
nucleus 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SGCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with SGCG: view

Pathways & Interactions for SGCG Gene

genes like me logo Genes that share pathways with SGCG: view

Gene Ontology (GO) - Biological Process for SGCG Gene


No data available for SIGNOR curated interactions for SGCG Gene

Drugs & Compounds for SGCG Gene

No Compound Related Data Available

Transcripts for SGCG Gene

mRNA/cDNA for SGCG Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SGCG Gene

Sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SGCG Gene

No ASD Table

Relevant External Links for SGCG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SGCG Gene

mRNA expression in normal human tissues for SGCG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SGCG Gene

This gene is overexpressed in Heart - Left Ventricle (x19.7), Muscle - Skeletal (x12.4), and Heart - Atrial Appendage (x11.2).

Protein differential expression in normal tissues from HIPED for SGCG Gene

This gene is overexpressed in Heart (50.2) and Tonsil (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SGCG Gene

SOURCE GeneReport for Unigene cluster for SGCG Gene Hs.37167

mRNA Expression by UniProt/SwissProt for SGCG Gene

Tissue specificity: Expressed in skeletal and heart muscle.
genes like me logo Genes that share expression patterns with SGCG: view

Protein tissue co-expression partners for SGCG Gene

- Elite partner

Primer Products

Orthologs for SGCG Gene

This gene was present in the common ancestor of animals.

Orthologs for SGCG Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SGCG 35
  • 82.25 (n)
  • 84.19 (a)
  • 84 (a)
(Canis familiaris)
Mammalia SGCG 35
  • 89.46 (n)
  • 93.13 (a)
  • 93 (a)
(Mus musculus)
Mammalia Sgcg 35
  • 82.59 (n)
  • 83.85 (a)
Sgcg 16
Sgcg 36
  • 84 (a)
(Pan troglodytes)
Mammalia SGCG 35
  • 99.43 (n)
  • 98.97 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Sgcg 35
  • 81.67 (n)
  • 84.19 (a)
(Monodelphis domestica)
Mammalia SGCG 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia SGCG 36
  • 85 (a)
(Gallus gallus)
Aves SGCG 35
  • 77.59 (n)
  • 83.1 (a)
  • 82 (a)
(Anolis carolinensis)
Reptilia SGCG 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sgcg 35
  • 73.79 (n)
  • 77.59 (a)
Str.15170 35
(Danio rerio)
Actinopterygii sgcg 35
  • 62.92 (n)
  • 64.21 (a)
sgcg 36
  • 63 (a)
sgcg 36
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta Scgdgr 37
  • 38 (a)
Scgdelta 36
  • 24 (a)
(Caenorhabditis elegans)
Secernentea sgn-1 37
  • 35 (a)
sgn-1 36
  • 29 (a)
Species with no ortholog for SGCG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SGCG Gene

Gene Tree for SGCG (if available)
Gene Tree for SGCG (if available)

Paralogs for SGCG Gene

Paralogs for SGCG Gene

(2) SIMAP similar genes for SGCG Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SGCG: view

Variants for SGCG Gene

Sequence variations from dbSNP and Humsavar for SGCG Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs17314986 - 23,250,679(+) TGCGC(A/G)CAACT reference, missense
VAR_010398 Limb-girdle muscular dystrophy 2C (LGMD2C)
rs1800354 - 23,324,525(+) GCACA(A/C/G)CCACA reference, missense
VAR_010430 Limb-girdle muscular dystrophy 2C (LGMD2C)
VAR_012202 Limb-girdle muscular dystrophy 2C (LGMD2C)

Structural Variations from Database of Genomic Variants (DGV) for SGCG Gene

Variant ID Type Subtype PubMed ID
esv2422437 CNV Duplication 17116639
esv2422502 CNV Duplication 17116639
esv2747122 CNV Deletion 23290073
esv5325 CNV Complex 18987735
esv2751135 CNV Gain 17911159
nsv455837 CNV Gain 19166990
nsv525965 CNV Gain 19592680
dgv1561n71 CNV Gain 21882294
dgv1563n71 CNV Gain 21882294
nsv455838 CNV Gain 19166990
nsv899911 CNV Gain 21882294
esv2751136 CNV Loss 17911159
nsv899918 CNV Gain 21882294
nsv899919 CNV Gain 21882294
nsv520725 CNV Loss 19592680
nsv517054 CNV Loss 19592680
esv22115 CNV Loss 19812545
esv259931 OTHER Complex 20981092
esv2747128 CNV Deletion 23290073
nsv471123 CNV Loss 18288195

Variation tolerance for SGCG Gene

Residual Variation Intolerance Score: 71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.43; 54.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SGCG Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SGCG Gene

Disorders for SGCG Gene

MalaCards: The human disease database

(10) MalaCards diseases for SGCG Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
muscular dystrophy, limb-girdle, type 2c
  • sarcoglycan, gamma
limb-girdle muscular dystrophy
  • erb's muscular dystrophy
muscular dystrophy
  • muscular dystrophies
muscular dystrophy, limb-girdle, type 2f
  • limb-girdle muscular dystrophy type 2f
- elite association - COSMIC cancer census association via MalaCards
Search SGCG in MalaCards View complete list of genes associated with diseases


  • Limb-girdle muscular dystrophy 2C (LGMD2C) [MIM:253700]: An autosomal recessive degenerative myopathy characterized by rapidly progressive muscle wasting from early childhood with loss of independent ambulation around age 12 years, dystrophic pattern on muscle biopsy, absence of gamma-sarcoglycan and normal dystrophin immunostaining. {ECO:0000269 PubMed:10714584, ECO:0000269 PubMed:8968757}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SGCG

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SGCG: view

No data available for Genatlas for SGCG Gene

Publications for SGCG Gene

  1. A founder mutation in the gamma-sarcoglycan gene of Gypsies possibly predating their migration out of India. (PMID: 8968757) Piccolo F. … Kaplan J.-C. (Hum. Mol. Genet. 1996) 2 3 4 23 67
  2. Low incidence of limb-girdle muscular dystrophy type 2C revealed by a mutation study in Japanese patients clinically diagnosed with DMD. (PMID: 20350330) Okizuka Y. … Matsuo M. (BMC Med. Genet. 2010) 3 23
  3. Spectrum of mutations in sarcoglycan genes in the Mumbai region of western India: high prevalence of 525del T. (PMID: 19770540) Khadilkar S.V. … Chong B. (Neurol India 2009) 3 23
  4. Sarcoglycanopathies and the risk of undetected deletion alleles in diagnosis. (PMID: 15954112) White S.J. … den Dunnen J.T. (Hum. Mutat. 2005) 3 23
  5. Gamma-sarcoglycan is required for the response of archvillin to mechanical stimulation in skeletal muscle. (PMID: 25605665) Spinazzola J.M. … Barton E.R. (Hum. Mol. Genet. 2015) 3

Products for SGCG Gene

Sources for SGCG Gene