SGCD Gene

Aliases
for SGCD gene

Previous GC identifers: GC05P155803 GC05P156305 GC05P155480 GC05P155734 GC05P155686 GC05P150847

Summaries
for SGCD gene

Genomic Views
for SGCD gene

RefSeq DNA sequence:

NC_000005.9  NC_018916.1  NT_023133.13  

SwitchGear Promoter luciferase reporter plasmid: SGCD promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SGCD

SGCD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P155297:  view genomic region     (about GC identifiers)

Proteins
for SGCD gene

Explore the universe of human proteins at neXtProt for SGCD: NX_Q92629

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 3): SGCD OriGene Custom Protein Services for SGCD
	GenScript Custom Purified and Recombinant Proteins Services for SGCD
	Novus Biologicals SGCD Proteins Novus Biologicals SGCD Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for SGCD (delta-Sarcoglycan)
	Browse OriGene Antibodies OriGene Custom Antibody Services for SGCD
	GenScript Custom Superior Antibodies Services for SGCD
	Novus Biologicals SGCD Antibodies
	Abcam antibodies for SGCD
	Browse Antibodies at Uscn
	Search ThermoFisher Antibodies for SGCD

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SGCD
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

Protein Domains /
Families
for SGCD gene

ProtoNet protein and cluster: Q92629

Function
for SGCD gene

miRNA Products:		OriGene 3'-UTR Clone (see all 3): SGCD Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SGCD
		8/100 QIAGEN miScript miRNA Assays for microRNAs that regulate SGCD (see all 100):
		hsa-miR-124* hsa-miR-579 hsa-miR-376b hsa-miR-15a hsa-miR-218-1* hsa-miR-489 hsa-miR-29a* hsa-miR-761
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SGCD (see all 7) OriGene shRNA RFP: SGCD OriGene siRNA: SGCD
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SGCD

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for SGCD

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SGCD (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SGCD (see all 4) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): SGCD (NM_172244)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SGCD
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SGCD

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SGCD
		Search LifeMap BioReagents cell lines for SGCD

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGCD

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Sgcd)

Pathways & Interactions
for SGCD gene

	Super-pathway	contained gene-specific pathways
1	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	Arrhythmogenic right ventricular cardiomyopathy (ARVC) 1.00 Arrhythmogenic right ventricular cardiomyopathy 0.99
2	Hypertrophic cardiomyopathy (HCM)	Hypertrophic cardiomyopathy (HCM) 1.00 Dilated cardiomyopathy 0.75
3	Allograft rejection	Viral myocarditis 0.33

1 BioSystems Pathway for SGCD

Arrhythmogenic right ventricular cardiomyopathy

4         Kegg Pathways  (Kegg details for SGCD)

	Hypertrophic cardiomyopathy (HCM)
	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
	Dilated cardiomyopathy
	Viral myocarditis

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for SGCD gene

Transcripts
for SGCD gene

Expression
for SGCD gene

SGCD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Stem Cell Differentiation: 2 LifeMap Cells
	Name			Category
	PureStem™ progenitor F15 (Embryonic Progenitor Cell)
	Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SGCD Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SGCD
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SGCD
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SGCD

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SGCD

Orthologs
for SGCD gene

Paralogs
for SGCD gene

Paralogs for SGCD gene

SGCG²  SGCZ²  

2 SIMAP similar genes for SGCD using alignment to 2 protein entries:     SGCD_HUMAN (see all proteins):

SGCG    SGCZ

SGCD for paralogs           About GeneDecksing

Genomic Variants
for SGCD gene

10/8019 NCBI SNPs in SGCD are shown (see all 8019)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs117485881,2	C,F,H,	non-pathogenic	189895168(+)	AAGTTT/CCTGCT	3	--	int1		5		NS EA EU	992
rs1219092981,2	C	pathogenic	189809000(+)	TCTTCG/TCTGCA	6	A S	mis1		0	--	--	--	--
rs1128812721,2	F	--	150845437(+)	CCCACG/ATAGAA	3	--	us2k1		2		CSA	4
rs777235791,2	C,	--	150845567(+)	TGTAAT/CTGTTA	3	--	us2k1		2		CSA WA	120
rs1165984201,2	C,F,	--	150845671(+)	CTGCAG/TATTTG	3	--	us2k1		1		WA	118
rs767740981,2	F,	--	150845707(+)	GTTAAT/CCTCAA	3	--	us2k1		1		WA	118
rs759520441,2	F,	--	150845816(+)	GGTGAC/GAGGCC	3	--	us2k1		1		WA	118
rs2015171241,2	C	--	150845960(-)	CAGTTA/TACTTT	3	--	us2k1		0	--	--	--	--
rs783027541,2	F,	--	150846556(+)	ACATAC/AAACAC	3	--	us2k1		1		WA	118
rs761692091,2		--	150846872(+)	GGAGTG/CTCATC	3	--	us2k1		2		CSA WA	120

HapMap Linkage Disequilibrium report for SGCD (155297354 - 155547354 bp, first 250kb of SGCD)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SGCD
     2 CNVs: 64347 7480
     1 Indel: 11249
Human Gene Mutation Database (HGMD): SGCD

Locus Specific Mutation Databases (LSDB): SGCD

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SGCD

DNA2.0 Custom Variant and Variant Library Synthesis for SGCD

Disorders / Diseases
for SGCD gene

11 diseases for SGCD

2 Novoseek disease relationships for SGCD gene    About this table

Publications
for SGCD gene

PubMed articles for SGCD gene, integrated from 9 sources (see all 52): (articles sorted by number of sources associating them with SGCD)

Utopia: connect your pdf to the dynamic world of online information

1. Mutations in the human delta-sarcoglycan gene in familial and sporadic dilated cardiomyopathy. (PubMed id 10974018)^{1, 2, 3} Tsubata S.... Towbin J.A. (2000)
2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
3. Filamin 2 (FLN2): a muscle-specific sarcoglycan interacting protein. (PubMed id 10629222)^{1, 2} Thompson T.G.... Kunkel L.M. (2000)
4. A first missense mutation in the delta sarcoglycan gene associated with a severe phenotype and frequency of limb-girdle muscular dystrophy type 2F (LGMD2F) in Brazilian sarcoglycanopathies. (PubMed id 9832045)^{1, 2} Moreira E.S....Passos-Bueno M.R. (1998)
5. Identification of a novel sarcoglycan gene at 5q33 encoding a sarcolemmal 35kDa glycoprotein. (PubMed id 8842738)^{1, 2} Nigro V.... Puca G.A. (1996)
6. Characterization of delta-sarcoglycan, a novel component of the oligomeric sarcoglycan complex involved in limb-girdle muscular dystrophy. (PubMed id 8943294)^{1, 2} Jung D.... Campbell K.P. (1996)
7. Autosomal recessive limb-girdle muscular dystrophy, LGMD2F, is caused by a mutation in the delta-sarcoglycan gene. (PubMed id 8841194)^{1, 3} Nigro V....Zatz M. (1996)
8. Linkage analysis in autosomal recessive limb-girdle muscular dystrophy (AR LGMD) maps a sixth form to 5q33-34 (LGMD2F) and indicates that there is at least one more subtype of AR LGMD. (PubMed id 8776597)^{1, 3} Passos-Bueno M.R....Zatz M. (1996)
9. A novel custom resequencing array for dilated cardiom yopathy. (PubMed id 20474083)¹ Zimmerman R.S....Funke B.H. (2010)
10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)

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Products
for SGCD gene