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Aliases for SFXN5 Gene

Aliases for SFXN5 Gene

  • Sideroflexin 5 2 3 5
  • Sideroflexin-5 3
  • BBG-TCC 3

External Ids for SFXN5 Gene

Previous GeneCards Identifiers for SFXN5 Gene

  • GC02M073178
  • GC02M073379
  • GC02M073143
  • GC02M073080
  • GC02M072904
  • GC02M073169

Summaries for SFXN5 Gene

GeneCards Summary for SFXN5 Gene

SFXN5 (Sideroflexin 5) is a Protein Coding gene. GO annotations related to this gene include cation transmembrane transporter activity and citrate transmembrane transporter activity. An important paralog of this gene is SFXN2.

UniProtKB/Swiss-Prot for SFXN5 Gene

  • Transports citrate. Potential iron transporter (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFXN5 Gene

Genomics for SFXN5 Gene

Regulatory Elements for SFXN5 Gene

Enhancers for SFXN5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F073109 1.4 FANTOM5 ENCODE 16 -36.3 -36277 5.2 ATF1 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 GLIS2 FOS ZNF263 RAB11FIP5 SFXN5 DUSP11 ENSG00000273245 EMX1 SPR SMYD5 ENSG00000272702 GC02M073097 PIR41361
GH02F073175 1.7 FANTOM5 Ensembl ENCODE 12.8 -101.0 -101036 3.2 HDGF CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 SMYD5 SFXN5 DUSP11 PRADC1 ENSG00000273245 NOTO SPR EMX1 CCT7 EGR4
GH02F073020 1.2 Ensembl ENCODE 11.8 +54.4 54422 1.7 ATF1 MLX ARID4B ZNF48 SLC30A9 FOS SP5 MIER2 REST PPARG RAB11FIP5 SFXN5 EMX1 SPR GC02P072995 LOC105374800
GH02F072983 0.9 ENCODE 15.2 +91.1 91119 1.8 ELF3 ARID4B THRB RAD21 ZNF48 SLC30A9 SCRT2 ZNF143 THAP11 SP5 RAB11FIP5 SFXN5 SPR GC02P072995 PIR59519
GH02F072999 1.2 Ensembl ENCODE 11.2 +74.6 74590 2.1 MLX ARID4B DMAP1 ZNF48 YY1 FOS PAF1 SP5 MXD4 MIER2 SFXN5 SPR RAB11FIP5 GC02P072995 LOC105374800
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SFXN5 on UCSC Golden Path with GeneCards custom track

Genomic Location for SFXN5 Gene

Chromosome:
2
Start:
72,942,036 bp from pter
End:
73,075,619 bp from pter
Size:
133,584 bases
Orientation:
Minus strand

Genomic View for SFXN5 Gene

Genes around SFXN5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFXN5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFXN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFXN5 Gene

Proteins for SFXN5 Gene

  • Protein details for SFXN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD22-SFXN5_HUMAN
    Recommended name:
    Sideroflexin-5
    Protein Accession:
    Q8TD22
    Secondary Accessions:
    • A8K116
    • Q494Y3
    • Q53T29

    Protein attributes for SFXN5 Gene

    Size:
    340 amino acids
    Molecular mass:
    37124 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SFXN5 Gene

Post-translational modifications for SFXN5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SFXN5 Gene

Domains & Families for SFXN5 Gene

Gene Families for SFXN5 Gene

Protein Domains for SFXN5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SFXN5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TD22

UniProtKB/Swiss-Prot:

SFXN5_HUMAN :
  • Belongs to the sideroflexin family.
Family:
  • Belongs to the sideroflexin family.
genes like me logo Genes that share domains with SFXN5: view

Function for SFXN5 Gene

Molecular function for SFXN5 Gene

UniProtKB/Swiss-Prot Function:
Transports citrate. Potential iron transporter (By similarity).

Gene Ontology (GO) - Molecular Function for SFXN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015075 ion transmembrane transporter activity IEA --
GO:0015137 citrate transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SFXN5: view
genes like me logo Genes that share phenotypes with SFXN5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SFXN5

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SFXN5 Gene

Localization for SFXN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFXN5 Gene

Mitochondrion membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SFXN5 gene
Compartment Confidence
mitochondrion 4
plasma membrane 3
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SFXN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031966 mitochondrial membrane IEA --
genes like me logo Genes that share ontologies with SFXN5: view

Pathways & Interactions for SFXN5 Gene

SuperPathways for SFXN5 Gene

No Data Available

Interacting Proteins for SFXN5 Gene

Gene Ontology (GO) - Biological Process for SFXN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0015746 citrate transport IEA --
GO:0034220 ion transmembrane transport IEA --
GO:0055072 iron ion homeostasis IEA --
genes like me logo Genes that share ontologies with SFXN5: view

No data available for Pathways by source and SIGNOR curated interactions for SFXN5 Gene

Drugs & Compounds for SFXN5 Gene

(1) Additional Compounds for SFXN5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
genes like me logo Genes that share compounds with SFXN5: view

Transcripts for SFXN5 Gene

Unigene Clusters for SFXN5 Gene

Sideroflexin 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SFXN5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
SP1: - - - -
SP2: -
SP3:
SP4: -
SP5: - - -
SP6: - -
SP7:

Relevant External Links for SFXN5 Gene

GeneLoc Exon Structure for
SFXN5
ECgene alternative splicing isoforms for
SFXN5

Expression for SFXN5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SFXN5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SFXN5 Gene

This gene is overexpressed in Brain - Amygdala (x4.6), Brain - Caudate (basal ganglia) (x4.2), and Brain - Nucleus accumbens (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for SFXN5 Gene

This gene is overexpressed in Frontal cortex (19.4) and Brain (15.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SFXN5 Gene



Protein tissue co-expression partners for SFXN5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SFXN5 Gene:

SFXN5

SOURCE GeneReport for Unigene cluster for SFXN5 Gene:

Hs.368171

mRNA Expression by UniProt/SwissProt for SFXN5 Gene:

Q8TD22-SFXN5_HUMAN
Tissue specificity: Primarily expressed in the brain.
genes like me logo Genes that share expression patterns with SFXN5: view

Primer Products

Orthologs for SFXN5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SFXN5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SFXN5 34 35
  • 99.61 (n)
cow
(Bos Taurus)
Mammalia SFXN5 34 35
  • 93.27 (n)
dog
(Canis familiaris)
Mammalia SFXN5 34 35
  • 93.23 (n)
rat
(Rattus norvegicus)
Mammalia Sfxn5 34
  • 91.3 (n)
mouse
(Mus musculus)
Mammalia Sfxn5 34 16 35
  • 90.67 (n)
oppossum
(Monodelphis domestica)
Mammalia SFXN5 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SFXN5 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves SFXN5 34 35
  • 80.4 (n)
lizard
(Anolis carolinensis)
Reptilia SFXN5 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sfxn5 34
  • 77.55 (n)
zebrafish
(Danio rerio)
Actinopterygii sfxn5b 34 35
  • 72.64 (n)
sfxn5a 35
  • 68 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sfxn-5 34 35
  • 52.05 (n)
sre-2 36
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FSF1 34 35 37
  • 47.37 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER336C 34
  • 47.34 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C07447g 34
  • 44.55 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 61 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU00227 34
  • 48.38 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC17G6.15c 34
  • 48.08 (n)
Species where no ortholog for SFXN5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SFXN5 Gene

ENSEMBL:
Gene Tree for SFXN5 (if available)
TreeFam:
Gene Tree for SFXN5 (if available)

Paralogs for SFXN5 Gene

Paralogs for SFXN5 Gene

(3) SIMAP similar genes for SFXN5 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for SFXN5 Gene

genes like me logo Genes that share paralogs with SFXN5: view

Variants for SFXN5 Gene

Sequence variations from dbSNP and Humsavar for SFXN5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10166058 -- 73,012,006(+) GGTGC(C/T)ATTCA intron-variant, upstream-variant-2KB
rs10166220 -- 73,042,087(+) GGCCA(C/G)AGTAA intron-variant
rs10167180 -- 72,982,836(+) GGGAG(A/G)AGAGG intron-variant
rs10167566 -- 73,058,017(+) GTGGA(C/T)ACACG intron-variant
rs10169188 -- 73,009,541(+) GAGCA(C/T)TGTCA intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for SFXN5 Gene

Variant ID Type Subtype PubMed ID
nsv953148 CNV deletion 24416366
nsv1002295 CNV gain 25217958
esv3591255 CNV loss 21293372
esv3591254 CNV loss 21293372
esv3558488 CNV deletion 23714750
esv27979 CNV loss 19812545
esv2674088 CNV deletion 23128226
esv2660274 CNV deletion 23128226
esv2636937 CNV deletion 19546169
esv2237523 CNV deletion 18987734
dgv1933n106 CNV deletion 24896259

Variation tolerance for SFXN5 Gene

Residual Variation Intolerance Score: 80.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SFXN5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SFXN5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFXN5 Gene

Disorders for SFXN5 Gene

Relevant External Links for SFXN5

Genetic Association Database (GAD)
SFXN5
Human Genome Epidemiology (HuGE) Navigator
SFXN5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SFXN5

No disorders were found for SFXN5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SFXN5 Gene

Publications for SFXN5 Gene

  1. The human sideroflexin 5 (SFXN5) gene: sequence, expression analysis and exclusion as a candidate for PARK3. (PMID: 12039050) Lockhart P.J. … Farrer M.J. (Gene 2002) 2 3 4 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SFXN5 Gene

Sources for SFXN5 Gene

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