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Aliases for SFXN5 Gene

Aliases for SFXN5 Gene

  • Sideroflexin 5 2 3
  • Sideroflexin-5 3
  • BBG-TCC 3

External Ids for SFXN5 Gene

Previous GeneCards Identifiers for SFXN5 Gene

  • GC02M073178
  • GC02M073379
  • GC02M073143
  • GC02M073080
  • GC02M072904
  • GC02M073169

Summaries for SFXN5 Gene

GeneCards Summary for SFXN5 Gene

SFXN5 (Sideroflexin 5) is a Protein Coding gene. GO annotations related to this gene include cation transmembrane transporter activity and citrate transmembrane transporter activity. An important paralog of this gene is SFXN4.

UniProtKB/Swiss-Prot for SFXN5 Gene

  • Transports citrate. Potential iron transporter (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFXN5 Gene

Genomics for SFXN5 Gene

Regulatory Elements for SFXN5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SFXN5 Gene

Start:
72,942,036 bp from pter
End:
73,075,619 bp from pter
Size:
133,584 bases
Orientation:
Minus strand

Genomic View for SFXN5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SFXN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFXN5 Gene

Proteins for SFXN5 Gene

  • Protein details for SFXN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD22-SFXN5_HUMAN
    Recommended name:
    Sideroflexin-5
    Protein Accession:
    Q8TD22
    Secondary Accessions:
    • A8K116
    • Q494Y3
    • Q53T29

    Protein attributes for SFXN5 Gene

    Size:
    340 amino acids
    Molecular mass:
    37124 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SFXN5 Gene

Proteomics data for SFXN5 Gene at MOPED

Post-translational modifications for SFXN5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SFXN5 Gene

No data available for DME Specific Peptides for SFXN5 Gene

Domains for SFXN5 Gene

Gene Families for SFXN5 Gene

HGNC:
  • SFXN :Sideroflexins

Protein Domains for SFXN5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SFXN5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TD22

UniProtKB/Swiss-Prot:

SFXN5_HUMAN :
  • Q8TD22
Family:
  • Belongs to the sideroflexin family.
genes like me logo Genes that share domains with SFXN5: view

Function for SFXN5 Gene

Molecular function for SFXN5 Gene

UniProtKB/Swiss-Prot Function:
Transports citrate. Potential iron transporter (By similarity).

Gene Ontology (GO) - Molecular Function for SFXN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008324 cation transmembrane transporter activity --
GO:0015075 ion transmembrane transporter activity --
GO:0015137 citrate transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SFXN5: view

Animal Model Products

miRNA for SFXN5 Gene

miRTarBase miRNAs that target SFXN5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SFXN5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SFXN5 Gene

Localization for SFXN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFXN5 Gene

Mitochondrion membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SFXN5 Gene COMPARTMENTS Subcellular localization image for SFXN5 gene
Compartment Confidence
mitochondrion 5
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for SFXN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SFXN5: view

Pathways for SFXN5 Gene

SuperPathways for SFXN5 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for SFXN5 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000272433%0d%0a9606.ENSP00000264705%0d%0a9606.ENSP00000402608%0d%0a9606.ENSP00000355890%0d%0a
Selected Interacting proteins: ENSP00000272433 Q8TD22-SFXN5_HUMAN for SFXN5 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SFXN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0015746 citrate transport IEA --
GO:0034220 ion transmembrane transport IEA --
GO:0055072 iron ion homeostasis IEA --
GO:0055085 transmembrane transport --
genes like me logo Genes that share ontologies with SFXN5: view

No data available for Pathways by source for SFXN5 Gene

Compounds for SFXN5 Gene

(1) HMDB Compounds for SFXN5 Gene

Compound Synonyms Cas Number PubMed IDs
Iron
  • Armco iron
7439-89-6
genes like me logo Genes that share compounds with SFXN5: view

Transcripts for SFXN5 Gene

Unigene Clusters for SFXN5 Gene

Sideroflexin 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SFXN5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SFXN5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
SP1: - - - -
SP2: -
SP3:
SP4: -
SP5: - - -
SP6: - -
SP7:

Relevant External Links for SFXN5 Gene

GeneLoc Exon Structure for
SFXN5
ECgene alternative splicing isoforms for
SFXN5

Expression for SFXN5 Gene

mRNA expression in normal human tissues for SFXN5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SFXN5 Gene

This gene is overexpressed in Brain - Amygdala (4.6), Brain - Caudate (basal ganglia) (4.2), and Brain - Nucleus accumbens (basal ganglia) (4.1).

Protein differential expression in normal tissues for SFXN5 Gene

This gene is overexpressed in Frontal cortex (19.4) and Brain (15.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SFXN5 Gene

SOURCE GeneReport for Unigene cluster for SFXN5 Gene Hs.368171

mRNA Expression by UniProt/SwissProt for SFXN5 Gene

Q8TD22-SFXN5_HUMAN
Tissue specificity: Primarily expressed in the brain.
genes like me logo Genes that share expressions with SFXN5: view

Expression partners for SFXN5 Gene

In Situ Assay Products

Orthologs for SFXN5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SFXN5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SFXN5 35
  • 93.27 (n)
  • 98.25 (a)
SFXN5 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SFXN5 35
  • 93.23 (n)
  • 98.44 (a)
SFXN5 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sfxn5 35
  • 90.67 (n)
  • 98.43 (a)
Sfxn5 16
Sfxn5 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SFXN5 35
  • 99.61 (n)
  • 100 (a)
SFXN5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sfxn5 35
  • 91.3 (n)
  • 98.43 (a)
oppossum
(Monodelphis domestica)
Mammalia SFXN5 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SFXN5 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves SFXN5 35
  • 80.4 (n)
  • 90.25 (a)
SFXN5 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SFXN5 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sfxn5 35
  • 77.55 (n)
  • 86.25 (a)
zebrafish
(Danio rerio)
Actinopterygii sfxn5b 35
  • 72.64 (n)
  • 78.62 (a)
sfxn5a 36
  • 68 (a)
OneToMany
sfxn5b 36
  • 78 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sre-2 37
  • 47 (a)
sfxn-5 35
  • 52.05 (n)
  • 50.79 (a)
sfxn-5 36
  • 50 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER336C 35
  • 47.34 (n)
  • 39.74 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C07447g 35
  • 44.55 (n)
  • 40.32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FSF1 35
  • 47.37 (n)
  • 40.19 (a)
FSF1 36
  • 39 (a)
OneToMany
FSF1 38
bread mold
(Neurospora crassa)
Ascomycetes NCU00227 35
  • 48.38 (n)
  • 41.23 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC17G6.15c 35
  • 48.08 (n)
  • 41.99 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 61 (a)
OneToOne
Species with no ortholog for SFXN5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SFXN5 Gene

ENSEMBL:
Gene Tree for SFXN5 (if available)
TreeFam:
Gene Tree for SFXN5 (if available)

Paralogs for SFXN5 Gene

Paralogs for SFXN5 Gene

Selected SIMAP similar genes for SFXN5 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for SFXN5 Gene

genes like me logo Genes that share paralogs with SFXN5: view

Variants for SFXN5 Gene

Sequence variations from dbSNP and Humsavar for SFXN5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs732178 -- 72,999,283(-) CTCCA(C/G)CCAGC intron-variant
rs732179 -- 72,999,153(-) CTTTG(A/G)GTCCT intron-variant
rs732180 -- 72,999,130(-) CCTTC(C/T)ACCCA intron-variant
rs755408 -- 72,943,407(+) CTAGG(G/T)GGGGT utr-variant-3-prime, nc-transcript-variant
rs755409 -- 72,943,601(+) GAGGC(A/G)ACACA utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for SFXN5 Gene

Variant ID Type Subtype PubMed ID
nsv874266 CNV Loss 21882294
esv2674088 CNV Deletion 23128226
esv27979 CNV Loss 19812545
esv2636937 CNV Deletion 19546169
esv2237523 CNV Deletion 18987734
esv2720203 CNV Deletion 23290073
esv2660274 CNV Deletion 23128226

Relevant External Links for SFXN5 Gene

HapMap Linkage Disequilibrium report
SFXN5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFXN5 Gene

Disorders for SFXN5 Gene

Relevant External Links for SFXN5

Genetic Association Database (GAD)
SFXN5
Human Genome Epidemiology (HuGE) Navigator
SFXN5

No disorders were found for SFXN5 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SFXN5 Gene

Publications for SFXN5 Gene

  1. The human sideroflexin 5 (SFXN5) gene: sequence, expression analysis and exclusion as a candidate for PARK3. (PMID: 12039050) Lockhart P.J. … Farrer M.J. (Gene 2002) 2 3 4
  2. Identification and characterization of a novel mitochondrial tricarboxylate carrier. (PMID: 12150972) Miyake S. … Tohyama M. (Biochem. Biophys. Res. Commun. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for SFXN5 Gene

Sources for SFXN5 Gene

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