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Aliases for SFXN5 Gene

Aliases for SFXN5 Gene

  • Sideroflexin 5 2 3 5
  • BBG-TCC 3

External Ids for SFXN5 Gene

Previous GeneCards Identifiers for SFXN5 Gene

  • GC02M073178
  • GC02M073379
  • GC02M073143
  • GC02M073080
  • GC02M072904
  • GC02M073169

Summaries for SFXN5 Gene

GeneCards Summary for SFXN5 Gene

SFXN5 (Sideroflexin 5) is a Protein Coding gene. GO annotations related to this gene include cation transmembrane transporter activity and citrate transmembrane transporter activity. An important paralog of this gene is SFXN3.

UniProtKB/Swiss-Prot for SFXN5 Gene

  • Transports citrate. Potential iron transporter (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFXN5 Gene

Genomics for SFXN5 Gene

Regulatory Elements for SFXN5 Gene

Genomic Location for SFXN5 Gene

Chromosome:
2
Start:
72,942,036 bp from pter
End:
73,075,619 bp from pter
Size:
133,584 bases
Orientation:
Minus strand

Genomic View for SFXN5 Gene

Genes around SFXN5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFXN5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFXN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFXN5 Gene

Proteins for SFXN5 Gene

  • Protein details for SFXN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD22-SFXN5_HUMAN
    Recommended name:
    Sideroflexin-5
    Protein Accession:
    Q8TD22
    Secondary Accessions:
    • A8K116
    • Q494Y3
    • Q53T29

    Protein attributes for SFXN5 Gene

    Size:
    340 amino acids
    Molecular mass:
    37124 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SFXN5 Gene

Proteomics data for SFXN5 Gene at MOPED

Post-translational modifications for SFXN5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SFXN5 Gene

No data available for DME Specific Peptides for SFXN5 Gene

Domains & Families for SFXN5 Gene

Gene Families for SFXN5 Gene

Protein Domains for SFXN5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SFXN5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TD22

UniProtKB/Swiss-Prot:

SFXN5_HUMAN :
  • Belongs to the sideroflexin family.
Family:
  • Belongs to the sideroflexin family.
genes like me logo Genes that share domains with SFXN5: view

Function for SFXN5 Gene

Molecular function for SFXN5 Gene

UniProtKB/Swiss-Prot Function:
Transports citrate. Potential iron transporter (By similarity).
genes like me logo Genes that share phenotypes with SFXN5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SFXN5

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SFXN5 Gene

Localization for SFXN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFXN5 Gene

Mitochondrion membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SFXN5 Gene COMPARTMENTS Subcellular localization image for SFXN5 gene
Compartment Confidence
mitochondrion 4
plasma membrane 3
nucleus 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SFXN5 Gene

Pathways & Interactions for SFXN5 Gene

SuperPathways for SFXN5 Gene

No Data Available

Interacting Proteins for SFXN5 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000272433%0d%0a9606.ENSP00000264705%0d%0a9606.ENSP00000402608%0d%0a9606.ENSP00000355890%0d%0a
Selected Interacting proteins: Q8TD22-SFXN5_HUMAN ENSP00000272433 for SFXN5 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for SFXN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015746 citrate transport IEA --
GO:0034220 ion transmembrane transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SFXN5: view

No data available for Pathways by source and SIGNOR curated interactions for SFXN5 Gene

Drugs & Compounds for SFXN5 Gene

(1) Additional Compounds for SFXN5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
genes like me logo Genes that share compounds with SFXN5: view

Transcripts for SFXN5 Gene

Unigene Clusters for SFXN5 Gene

Sideroflexin 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SFXN5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
SP1: - - - -
SP2: -
SP3:
SP4: -
SP5: - - -
SP6: - -
SP7:

Relevant External Links for SFXN5 Gene

GeneLoc Exon Structure for
SFXN5
ECgene alternative splicing isoforms for
SFXN5

Expression for SFXN5 Gene

mRNA expression in normal human tissues for SFXN5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SFXN5 Gene

This gene is overexpressed in Brain - Amygdala (x4.6), Brain - Caudate (basal ganglia) (x4.2), and Brain - Nucleus accumbens (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for SFXN5 Gene

This gene is overexpressed in Frontal cortex (19.4) and Brain (15.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SFXN5 Gene



SOURCE GeneReport for Unigene cluster for SFXN5 Gene Hs.368171

mRNA Expression by UniProt/SwissProt for SFXN5 Gene

Q8TD22-SFXN5_HUMAN
Tissue specificity: Primarily expressed in the brain.
genes like me logo Genes that share expression patterns with SFXN5: view

Protein tissue co-expression partners for SFXN5 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SFXN5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SFXN5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SFXN5 36
  • 100 (a)
OneToOne
SFXN5 35
  • 99.61 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia SFXN5 35
  • 93.27 (n)
  • 98.25 (a)
SFXN5 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SFXN5 36
  • 98 (a)
OneToOne
SFXN5 35
  • 93.23 (n)
  • 98.44 (a)
mouse
(Mus musculus)
Mammalia Sfxn5 36
  • 97 (a)
OneToOne
Sfxn5 16
Sfxn5 35
  • 90.67 (n)
  • 98.43 (a)
oppossum
(Monodelphis domestica)
Mammalia SFXN5 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SFXN5 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sfxn5 35
  • 91.3 (n)
  • 98.43 (a)
chicken
(Gallus gallus)
Aves SFXN5 35
  • 80.4 (n)
  • 90.25 (a)
SFXN5 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SFXN5 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sfxn5 35
  • 77.55 (n)
  • 86.25 (a)
zebrafish
(Danio rerio)
Actinopterygii sfxn5b 35
  • 72.64 (n)
  • 78.62 (a)
sfxn5a 36
  • 68 (a)
OneToMany
sfxn5b 36
  • 78 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sre-2 37
  • 47 (a)
sfxn-5 36
  • 50 (a)
OneToMany
sfxn-5 35
  • 52.05 (n)
  • 50.79 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER336C 35
  • 47.34 (n)
  • 39.74 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FSF1 35
  • 47.37 (n)
  • 40.19 (a)
FSF1 36
  • 39 (a)
OneToMany
FSF1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C07447g 35
  • 44.55 (n)
  • 40.32 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00227 35
  • 48.38 (n)
  • 41.23 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC17G6.15c 35
  • 48.08 (n)
  • 41.99 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 61 (a)
OneToOne
Species with no ortholog for SFXN5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SFXN5 Gene

ENSEMBL:
Gene Tree for SFXN5 (if available)
TreeFam:
Gene Tree for SFXN5 (if available)

Paralogs for SFXN5 Gene

Paralogs for SFXN5 Gene

(3) SIMAP similar genes for SFXN5 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for SFXN5 Gene

genes like me logo Genes that share paralogs with SFXN5: view

Variants for SFXN5 Gene

Sequence variations from dbSNP and Humsavar for SFXN5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs732178 -- 72,999,283(-) CTCCA(C/G)CCAGC intron-variant
rs1036512 -- 73,025,323(+) CTCCC(A/C)CCTCT intron-variant
rs1133804 -- 72,961,246(-) GAAGA(A/C)GGCTC intron-variant, nc-transcript-variant, reference, synonymous-codon, missense
rs1898443 -- 72,977,817(+) taaaa(A/T)acaaa intron-variant
rs2164733 -- 72,945,843(-) ATGGG(A/G)GCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SFXN5 Gene

Variant ID Type Subtype PubMed ID
nsv874266 CNV Loss 21882294
esv2674088 CNV Deletion 23128226
esv27979 CNV Loss 19812545
esv2636937 CNV Deletion 19546169
esv2237523 CNV Deletion 18987734
esv2720203 CNV Deletion 23290073
esv2660274 CNV Deletion 23128226

Variation tolerance for SFXN5 Gene

Residual Variation Intolerance Score: 80.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SFXN5 Gene

HapMap Linkage Disequilibrium report
SFXN5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFXN5 Gene

Disorders for SFXN5 Gene

Relevant External Links for SFXN5

Genetic Association Database (GAD)
SFXN5
Human Genome Epidemiology (HuGE) Navigator
SFXN5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SFXN5

No disorders were found for SFXN5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SFXN5 Gene

Publications for SFXN5 Gene

  1. The human sideroflexin 5 (SFXN5) gene: sequence, expression analysis and exclusion as a candidate for PARK3. (PMID: 12039050) Lockhart P.J. … Farrer M.J. (Gene 2002) 2 3 4 67
  2. Identification and characterization of a novel mitochondrial tricarboxylate carrier. (PMID: 12150972) Miyake S. … Tohyama M. (Biochem. Biophys. Res. Commun. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3

Products for SFXN5 Gene

Sources for SFXN5 Gene

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