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Aliases for SFXN5 Gene

Aliases for SFXN5 Gene

  • Sideroflexin 5 2 3 5
  • Sideroflexin-5 3
  • BBG-TCC 3
  • SLC56A5 3

External Ids for SFXN5 Gene

Previous GeneCards Identifiers for SFXN5 Gene

  • GC02M073178
  • GC02M073379
  • GC02M073143
  • GC02M073080
  • GC02M072904
  • GC02M073169

Summaries for SFXN5 Gene

GeneCards Summary for SFXN5 Gene

SFXN5 (Sideroflexin 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include cation transmembrane transporter activity and citrate transmembrane transporter activity. An important paralog of this gene is SFXN2.

UniProtKB/Swiss-Prot for SFXN5 Gene

  • Transports citrate. Potential iron transporter (By similarity).

Additional gene information for SFXN5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFXN5 Gene

Genomics for SFXN5 Gene

GeneHancer (GH) Regulatory Elements for SFXN5 Gene

Promoters and enhancers for SFXN5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I073069 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +4.7 4680 3.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 SFXN5 DUSP11 CCT7 ENSG00000273245 ALMS1 TPRKB SMYD5 DGUOK-AS1 RAB11FIP5 GC02M073119
GH02I073109 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 16 -36.3 -36276 5.2 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 GLIS2 FOS SP3 RAB11FIP5 ENSG00000272702 DUSP11 ENSG00000273245 SFXN5 EMX1 SPR SMYD5 GC02M073116 PIR41361
GH02I073175 Enhancer 1.6 FANTOM5 Ensembl ENCODE 12.9 -101.0 -101035 3.2 HDGF ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 ZNF213 E2F8 SMYD5 ALMS1 DUSP11 SFXN5 PRADC1 NOTO SPR ENSG00000273245 EMX1 CCT7
GH02I072915 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE 9.3 +158.2 158216 4.2 PKNOX1 ARID4B ZNF48 GLIS2 ZNF207 RUNX3 SP3 SP5 NFYC REST EMX1 SPR SFXN5 ENSG00000278060
GH02I072983 Enhancer 0.7 ENCODE 15.2 +91.1 91119 1.8 DRAP1 FOXA2 SAP130 ARID4B MAX RAD21 THRB YY1 SP5 RXRA RAB11FIP5 SFXN5 SPR GC02P072995 PIR59519
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SFXN5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SFXN5 gene promoter:

Genomic Locations for SFXN5 Gene

Genomic Locations for SFXN5 Gene
133,584 bases
Minus strand

Genomic View for SFXN5 Gene

Genes around SFXN5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFXN5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFXN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFXN5 Gene

Proteins for SFXN5 Gene

  • Protein details for SFXN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K116
    • Q494Y3
    • Q53T29

    Protein attributes for SFXN5 Gene

    340 amino acids
    Molecular mass:
    37124 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SFXN5 Gene

Post-translational modifications for SFXN5 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SFXN5 Gene

Domains & Families for SFXN5 Gene

Gene Families for SFXN5 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for SFXN5 Gene


Suggested Antigen Peptide Sequences for SFXN5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sideroflexin family.
  • Belongs to the sideroflexin family.
genes like me logo Genes that share domains with SFXN5: view

Function for SFXN5 Gene

Molecular function for SFXN5 Gene

UniProtKB/Swiss-Prot Function:
Transports citrate. Potential iron transporter (By similarity).

Phenotypes From GWAS Catalog for SFXN5 Gene

Gene Ontology (GO) - Molecular Function for SFXN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015075 ion transmembrane transporter activity IEA --
GO:0015137 citrate transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SFXN5: view
genes like me logo Genes that share phenotypes with SFXN5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SFXN5 Gene

Localization for SFXN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFXN5 Gene

Mitochondrion membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SFXN5 gene
Compartment Confidence
mitochondrion 4
plasma membrane 3
nucleus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SFXN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031966 mitochondrial membrane IEA --
genes like me logo Genes that share ontologies with SFXN5: view

Pathways & Interactions for SFXN5 Gene

SuperPathways for SFXN5 Gene

No Data Available

Interacting Proteins for SFXN5 Gene

Gene Ontology (GO) - Biological Process for SFXN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0015746 citrate transport IEA --
GO:0034220 ion transmembrane transport IEA --
GO:0055072 iron ion homeostasis IEA --
genes like me logo Genes that share ontologies with SFXN5: view

No data available for Pathways by source and SIGNOR curated interactions for SFXN5 Gene

Drugs & Compounds for SFXN5 Gene

(1) Additional Compounds for SFXN5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
genes like me logo Genes that share compounds with SFXN5: view

Transcripts for SFXN5 Gene

Unigene Clusters for SFXN5 Gene

Sideroflexin 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SFXN5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
SP1: - - - -
SP2: -
SP4: -
SP5: - - -
SP6: - -

Relevant External Links for SFXN5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SFXN5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SFXN5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SFXN5 Gene

This gene is overexpressed in Brain - Amygdala (x4.6), Brain - Caudate (basal ganglia) (x4.2), and Brain - Nucleus accumbens (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for SFXN5 Gene

This gene is overexpressed in Frontal cortex (19.4) and Brain (15.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SFXN5 Gene

Protein tissue co-expression partners for SFXN5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SFXN5 Gene:


SOURCE GeneReport for Unigene cluster for SFXN5 Gene:


mRNA Expression by UniProt/SwissProt for SFXN5 Gene:

Tissue specificity: Primarily expressed in the brain.

Evidence on tissue expression from TISSUES for SFXN5 Gene

  • Nervous system(4.9)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with SFXN5: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SFXN5 Gene

Orthologs for SFXN5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SFXN5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SFXN5 33 34
  • 99.61 (n)
(Bos Taurus)
Mammalia SFXN5 33 34
  • 93.27 (n)
(Canis familiaris)
Mammalia SFXN5 33 34
  • 93.23 (n)
(Rattus norvegicus)
Mammalia Sfxn5 33
  • 91.3 (n)
(Mus musculus)
Mammalia Sfxn5 33 16 34
  • 90.67 (n)
(Monodelphis domestica)
Mammalia SFXN5 34
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia SFXN5 34
  • 71 (a)
(Gallus gallus)
Aves SFXN5 33 34
  • 80.4 (n)
(Anolis carolinensis)
Reptilia SFXN5 34
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sfxn5 33
  • 77.55 (n)
(Danio rerio)
Actinopterygii sfxn5b 33 34
  • 72.64 (n)
sfxn5a 34
  • 68 (a)
(Caenorhabditis elegans)
Secernentea sfxn-5 33 34
  • 52.05 (n)
sre-2 35
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FSF1 33 34 36
  • 47.37 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER336C 33
  • 47.34 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C07447g 33
  • 44.55 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 61 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00227 33
  • 48.38 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC17G6.15c 33
  • 48.08 (n)
Species where no ortholog for SFXN5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SFXN5 Gene

Gene Tree for SFXN5 (if available)
Gene Tree for SFXN5 (if available)

Paralogs for SFXN5 Gene

Paralogs for SFXN5 Gene

(3) SIMAP similar genes for SFXN5 Gene using alignment to 5 proteins: Pseudogenes for SFXN5 Gene

genes like me logo Genes that share paralogs with SFXN5: view

Variants for SFXN5 Gene

Sequence variations from dbSNP and Humsavar for SFXN5 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000034416 -- 72,958,998(-) C/T intron_variant
rs1000048300 -- 72,954,066(-) G/A intron_variant
rs1000054018 -- 72,994,035(-) C/T intron_variant
rs1000066399 -- 72,998,739(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000069931 -- 72,981,733(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SFXN5 Gene

Variant ID Type Subtype PubMed ID
dgv1933n106 CNV deletion 24896259
esv2237523 CNV deletion 18987734
esv2636937 CNV deletion 19546169
esv2660274 CNV deletion 23128226
esv2674088 CNV deletion 23128226
esv27979 CNV loss 19812545
esv3558488 CNV deletion 23714750
esv3591254 CNV loss 21293372
esv3591255 CNV loss 21293372
nsv1002295 CNV gain 25217958
nsv953148 CNV deletion 24416366

Variation tolerance for SFXN5 Gene

Residual Variation Intolerance Score: 80.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SFXN5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFXN5 Gene

Disorders for SFXN5 Gene

Additional Disease Information for SFXN5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SFXN5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SFXN5 Gene

Publications for SFXN5 Gene

  1. The human sideroflexin 5 (SFXN5) gene: sequence, expression analysis and exclusion as a candidate for PARK3. (PMID: 12039050) Lockhart PJ … Farrer MJ (Gene 2002) 2 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for SFXN5 Gene

Sources for SFXN5 Gene

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