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SFXN4 Gene

protein-coding   GIFtS: 52
GCID: GC10M120890

Sideroflexin 4

  See SFXN4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sideroflexin 41 2
Breast Cancer Resistance Marker 12 3
BCRM12 3
COXPD182 5
sideroflexin-42

External Ids:    HGNC: 160881   Entrez Gene: 1195592   Ensembl: ENSG000001836057   OMIM: 6155645   UniProtKB: Q6P4A73   

Export aliases for SFXN4 gene to outside databases

Previous GC identifers: GC00U991058 GC10M120143 GC10M121032 GC10M120565 GC10M120535 GC10M114530


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SFXN4 Gene:
This gene encodes a member of the sideroflexin family. The encoded protein is a transmembrane protein of the inner
mitochondrial membrane, and is required for mitochondrial respiratory homeostasis and erythropoiesis. Mutations
in this gene are associated with mitochondriopathy and macrocytic anemia. Alternatively spliced transcript
variants have been found in this gene. (provided by RefSeq, Jan 2014)

GeneCards Summary for SFXN4 Gene:
SFXN4 (sideroflexin 4) is a protein-coding gene. Diseases associated with SFXN4 include combined oxidative phosphorylation deficiency 18, and macrocytic anemia. GO annotations related to this gene include cation transmembrane transporter activity. An important paralog of this gene is SFXN1.

UniProtKB/Swiss-Prot: SFXN4_HUMAN, Q6P4A7
Function: Potential iron transporter (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SFXN4 gene promoter:
         AREB6   Pbx1a   NF-kappaB2   Msx-1   NF-kappaB   NF-kappaB1   Ik-1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSFXN4 promoter sequence
   Search Chromatin IP Primers for SFXN4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SFXN4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.11   Ensembl cytogenetic band:  10q26.11   HGNC cytogenetic band: 10q26.11

SFXN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SFXN4 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M120890:  view genomic region     (about GC identifiers)

Start:
120,900,279 bp from pter      End:
120,925,204 bp from pter
Size:
24,926 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SFXN4_HUMAN, Q6P4A7 (See protein sequence)
Recommended Name: Sideroflexin-4  
Size: 337 amino acids; 37998 Da
Secondary accessions: Q6WSU4 Q86TD9
Alternative splicing: 3 isoforms:  Q6P4A7-1   Q6P4A7-2   Q6P4A7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SFXN4: NX_Q6P4A7

Explore proteomics data for SFXN4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys106, Lys230
  • Modification sites at PhosphoSitePlus

  • See SFXN4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_998814.1  
    ENSEMBL proteins: 
     ENSP00000347924   ENSP00000358127   ENSP00000414193   ENSP00000333200  

    SFXN4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SFXN4

     
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    antibodies-online peptides for SFXN4

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    antibodies-online antibodies for SFXN4 (18 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SFXN: Sideroflexins

    2 InterPro protein domains:
     IPR028825 SFXN4
     IPR004686 Mtc

    Graphical View of Domain Structure for InterPro Entry Q6P4A7

    ProtoNet protein and cluster: Q6P4A7

    1 Blocks protein domain: IPB004686 Tricarboxylate/iron carrier

    UniProtKB/Swiss-Prot: SFXN4_HUMAN, Q6P4A7
    Similarity: Belongs to the sideroflexin family


    Find genes that share domains with SFXN4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SFXN4_HUMAN, Q6P4A7
    Function: Potential iron transporter (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008324cation transmembrane transporter activity IEA--
         
    Find genes that share ontologies with SFXN4           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SFXN4

    miRNA
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    Block miRNA regulation of human, mouse, rat SFXN4 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate SFXN4:
    hsa-miR-27a hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidSFXN4 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SFXN4
    Predesigned siRNA for gene silencing in human, mouse, rat SFXN4

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    GenScript: all cDNA clones in your preferred vector: SFXN4 (NM_213649)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFXN4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SFXN4_HUMAN, Q6P4A7: Mitochondrion inner membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    endoplasmic reticulum1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0031966mitochondrial membrane ----

    Find genes that share ontologies with SFXN4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SFXN4
    Interactions:

        Search GeneGlobe Interaction Network for SFXN4

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for SFXN4 (Q6P4A73 ENSP000003479244) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BABAM1Q9NWV83, ENSP000003524084I2D: score=2 STRING: ENSP00000352408
    CLN3Q132863, ENSP000003530734I2D: score=3 STRING: ENSP00000353073
    TSC22D1Q157143, ENSP000003974354I2D: score=1 STRING: ENSP00000397435
    FYNP062413I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006812cation transport ----
    GO:0055072iron ion homeostasis IEA--
    GO:0055085transmembrane transport ----

    Find genes that share ontologies with SFXN4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SFXN4

    1 HMDB Compound for SFXN4    About this table
    CompoundSynonyms CAS #PubMed Ids
    IronArmco iron (see all 19)7439-89-6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SFXN4 gene (2 alternative transcripts): 
    NM_213649.1  NM_178867.3  

    Unigene Cluster for SFXN4:

    Sideroflexin 4
    Hs.655168  [show with all ESTs]
    Unigene Representative Sequence: BC050475
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000490417 ENST00000484960 ENST00000355697(uc001ldy.3 uc001leb.3 uc001lea.3)
    ENST00000461438 ENST00000369131 ENST00000466218 ENST00000419372 ENST00000462913
    ENST00000330036
    miRNA
    Products:
         
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    2 qRT-PCR Assays for microRNAs that regulate SFXN4:
    hsa-miR-27a hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidSFXN4 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SFXN4
      QuantiTect SYBR Green Assays in human, mouse, rat SFXN4
      QuantiFast Probe-based Assays in human, mouse, rat SFXN4

    Additional mRNA sequence: 

    AY269785.1 BC050475.1 BC063562.1 

    10 DOTS entries:

    DT.100663296  DT.87016601  DT.87016599  DT.100811192  DT.100811193  DT.100811186  DT.92431518  DT.100811183 
    DT.444577  DT.40274822 

    Selected AceView cDNA sequences (see all 223):

    BX343293 AI291700 CR610013 NM_213649 BE252549 AA972928 AI127267 AA044164 
    BM782500 BQ186183 AI144205 BM930783 AI300110 AA642354 BM685179 CA842907 
    AL522341 BX400877 BM021472 AA504824 BG035720 AA044245 CR621683 CR608481 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SFXN4 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                    -           -           -                                                     -                           
    SP2:                                -           -                                                                                 
    SP3:                                                                                                  -                 -         
    SP4:                                                                                                                              
    SP5:                    -           -                                                                                             


    ECgene alternative splicing isoforms for SFXN4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SFXN4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACAAGGAAG
    SFXN4 Expression
    About this image


    SFXN4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    SFXN4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SFXN4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655168
        Custom PCR Arrays for SFXN4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFXN4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SFXN4 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sfxn41 , 5 sideroflexin 41, 5 71.46(n)1
    61.34(a)1
      19 (56.52 cM)5
    942811  NM_053198.31  NP_444428.31 
     608372775 
    chicken
    (Gallus gallus)
    Aves SFXN41 sideroflexin 4 52.94(n)
    40.25(a)
      771604  XM_001234860.3  XP_001234861.2 
    lizard
    (Anolis carolinensis)
    Reptilia SFXN46
    sideroflexin 4
    40(a)
    1 ↔ 1
    GL343399.1(480529-529575)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.89552 Xenopus laevis transcribed sequence with moderate similarity more 74.96(n)    CA980988.1 
    zebrafish
    (Danio rerio)
    Actinopterygii prdx32 peroxiredoxin 3 74.04(n)   373079  CK352837.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sfxn-56
    Protein SFXN-5 (sfxn-5) mRNA, complete cds
    24(a)
    1 → many
    II(8102129-8105052) WBGene00044049
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FSF16
    Putative protein, predicted to be an alpha-isoprop...
    21(a)
    1 → many
    XV(831059-832042) YOR271C


    ENSEMBL Gene Tree for SFXN4 (if available)
    TreeFam Gene Tree for SFXN4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SFXN4 gene
    SFXN12  SFXN52  SFXN22  SFXN32  

    Find genes that share paralogs with SFXN4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SFXN4
    PGOHUM00000240367


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SFXN4 (see all 663)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1893057071,2
    C--114529586(+) CAGGCA/GATCCA 1 -- ds50010--------
    rs1820522961,2
    --114529612(+) CAAAGC/TGCTGG 1 -- ds50010--------
    rs1502905121,2
    --114529628(+) CAGGCA/GTGAGC 1 -- ds50010--------
    rs1154836701,2
    F--114529636(+) AGCCAC/ACGCGC 1 -- ds50011Minor allele frequency- A:0.14WA 118
    rs1139648211,2
    C--114529640(+) ACCGCG/ACCTGG 1 -- ds50013Minor allele frequency- A:0.16CSA WA EA 240
    rs1860780751,2
    --114529647(+) CTGGCC/TGACAA 1 -- ds50010--------
    rs2019981611,2
    --114529718(+) GAAGC-/AGAGAGA 1 -- ds50010--------
    rs1900964251,2
    --114529743(+) GAGGAC/TGCTGG 1 -- ds50010--------
    rs79121151,2
    C,F,H--114529760(+) ACGGAG/AGAAGG 1 -- ds500110Minor allele frequency- A:0.16NS EA NA WA 782
    rs1449511741,2
    C--114529816(+) CCTGGA/CGGAGG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SFXN4 (120900279 - 120925204 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SFXN4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv825583CNV Gain20364138

    Human Gene Mutation Database (HGMD): SFXN4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SFXN4
    DNA2.0 Custom Variant and Variant Library Synthesis for SFXN4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615564   
    OMIM disorders: 615578  
    UniProtKB/Swiss-Prot: SFXN4_HUMAN, Q6P4A7
  • Combined oxidative phosphorylation deficiency 18 (COXPD18) [MIM:615578]: An autosomal recessive disorder
    of mitochondrial dysfunction characterized by intrauterine growth retardation, hypotonia, visual impairment,
    speech delay, and lactic acidosis associated with decreased mitochondrial respiratory chain activity. Affected
    patients may also show hematologic abnormalities, mainly macrocytic anemia. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 3 diseases for SFXN4:    
    About MalaCards
    combined oxidative phosphorylation deficiency 18    macrocytic anemia    breast cancer


    Find genes that share disorders with SFXN4           About GenesLikeMe

    Genetic Association Database (GAD): SFXN4
    Human Genome Epidemiology (HuGE) Navigator: SFXN4 (3 documents)

    Export disorders for SFXN4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SFXN4 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with SFXN4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel human putative transmembrane protein homologous to mouse sideroflexin associated with sideroblastic anemia. (PubMed id 14756423)1, 2, 3, 9 Zheng H.... Mao Y. (DNA Seq. 2003)
    2. Macrocytic anemia and mitochondriopathy resulting from a defect in sideroflexin 4. (PubMed id 24119684)1, 2 Hildick-Smith G.J....Paw B.H. (Am. J. Hum. Genet. 2013)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    7. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 119559 HGNC: 16088 AceView: SFXN4 Ensembl:ENSG00000183605 euGenes: HUgn119559
    ECgene: SFXN4 H-InvDB: SFXN4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SFXN4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SFXN4 gene:
    Search GeneIP for patents involving SFXN4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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