SFXN4 Gene
protein-coding GIFtS: 46
GCID: GC10M120890
|
|
sideroflexin 4
| |
Aliases for SFXN4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Sideroflexin 41 2 | | Breast Cancer Resistance Marker 12 3 | | BCRM12 3 | | Sideroflexin-41 |
Export aliases for SFXN4 gene to outside databasesPrevious GC identifers: GC00U991058 GC10M120143 GC10M121032 GC10M120565 GC10M120535 GC10M114530 |
Summaries for SFXN4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: SFXN4_HUMAN, Q6P4A7Function: Potential iron transporter (By similarity)
|
Genomic Views for SFXN4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SFXN4 gene promoter: AREB6 Pbx1a NF-kappaB2 Msx-1 NF-kappaB NF-kappaB1 Ik-1 Hlf Other transcription factors
Search SABiosciences Chromatin IP Primers for SFXN4
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SFXN4 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q26.11 Ensembl cytogenetic band: 10q26.11 HGNC cytogenetic band: 10q26.11SFXN4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M120890: view genomic region
(about GC identifiers)
Start:
|
120,900,279 bp from pter |
End:
|
120,925,204 bp from pter |
Size:
|
24,926 bases |
Orientation:
|
minus strand |
|
Proteins for SFXN4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: SFXN4_HUMAN, Q6P4A7 (See
protein sequence)Recommended Name: Sideroflexin-4 Size: 337 amino acids; 37998 Da
Subcellular location: Mitochondrion membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: Q6WSU4 Q86TD9Alternative splicing: 3 isoforms: Q6P4A7-1 Q6P4A7-2 Q6P4A7-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SFXN4: NX_Q6P4A7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6P4A7 SFXN4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_998814.1 ENSEMBL proteins: ENSP00000437244 ENSP00000347924 ENSP00000358127 ENSP00000414193 ENSP00000333200 Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
SFXN4 for ontologies About GeneDecksing
SFXN4 Antibody Products: Assay Products for SFXN4: |
Protein
Domains / Families for SFXN4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SFXN4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6P4A7ProtoNet protein and cluster: Q6P4A7 1 Blocks protein family: IPB004686 Tricarboxylate/iron carrier
UniProtKB/Swiss-Prot: SFXN4_HUMAN, Q6P4A7Similarity: Belongs to the sideroflexin family |
Function for SFXN4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: SFXN4_HUMAN, Q6P4A7Function: Potential iron transporter (By similarity)
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFXN4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFXN4 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SFXN4 (NM_213649) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SFXN4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFXN4  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFXN4 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008324 | cation transmembrane transporter activity |
IEA | -- |
SFXN4 for ontologies About GeneDecksing
|
Pathways & Interactions for SFXN4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SFXN4
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
 5 Interacting proteins for SFXN4 (Q6P4A73 ENSP000003479244) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0055072 | iron ion homeostasis |
IEA | -- |
SFXN4 for ontologies About GeneDecksing
|
Drugs & Compounds for SFXN4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for SFXN4
1 HMDB Compound for SFXN4 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Iron | Armco iron (see all 19) | 7439-89-6 | -- | Search CenterWatch for drugs/clinical trials and news about SFXN4 
|
Transcripts for SFXN4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for SFXN4 gene (2 alternative transcripts): NM_178867.3 NM_213649.1 Unigene Cluster for SFXN4: Sideroflexin 4 Hs.655168 [show with all ESTs]Unigene Representative Sequence: BC0504759 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000490417 ENST00000355697(uc001ldy.3 uc001leb.3 uc001lea.3) ENST00000484960 ENST00000461438 ENST00000369131 ENST00000466218 ENST00000419372 ENST00000462913 ENST00000330036
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFXN4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFXN4 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SFXN4 (NM_213649) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SFXN4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFXN4  |
Additional cDNA sequence: AY269785.1 BC050475.1 BC063562.1 10 DOTS entries: DT.100663296 DT.87016601 DT.87016599 DT.100811192 DT.100811193 DT.100811186 DT.92431518 DT.100811183 DT.444577 DT.40274822 24/223 AceView cDNA sequences (see all 223): AA830947 AL522341 BG035720 NM_213650 BQ000934 AA205530 CR612708 BG474702 AI300110 CR612933 AA642354 BM930783 AA731463 AI924888 CR610013 AA504824 AW182383 CA842907 AA235483 BQ186183 BM021472 BM972933 CR603154 AA044245 GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SFXN4 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | |
| SP1: | |   | |   | |   | - |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for SFXN4
|
Expression for SFXN4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SFXN4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GACAAGGAAG
About this image See SFXN4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SFXN4
SOURCE GeneReport for Unigene cluster: Hs.655168 SABiosciences Custom PCR Arrays for SFXN4
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SFXN4 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SFXN4 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SFXN4 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SFXN4 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFXN4 |
Orthologs for SFXN4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SFXN4 gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
SFXN41 |
sideroflexin 4 |
53.07(n) 39.81(a) |
  |
771604 XM_001234860.2 XP_001234861.1 |
lizard (Anolis carolinensis) |
Reptilia |
SFXN46 |
-- |
41(a) |
1 ↔ 1 |
GL343399.1(483131-495716) |
African clawed frog (Xenopus laevis) |
Amphibia |
Xl.89552 |
Xenopus laevis transcribed sequence with moderate similarity more |
74.96(n) |
  |
CA980988.1 |
zebrafish (Danio rerio) |
Actinopterygii |
prdx32 |
peroxiredoxin 3 |
74.04(n) |
  |
373079 CK352837.1 |
worm (Caenorhabditis elegans) |
Secernentea |
sfxn-56 |
Sideroflexin-5 |
23(a) |
1 ↔ 1 |
II(8102077-8105000) |
ENSEMBL Gene Tree for SFXN4 (if available) TreeFam Gene Tree for SFXN4 (if available)  |
Paralogs for SFXN4 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for SFXN4 gene
- SFXN12 SFXN52 SFXN22 SFXN32
SFXN4 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SFXN4 PGOHUM00000240367
|
Genomic Variants for SFXN4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 10 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for SFXN4 (120900279 - 120925204 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for SFXN4: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SFXN4 |
|
Disorders
/ Diseases for SFXN4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SFXN4 for disorders About GeneDecksing
6 diseases for SFXN4: About MalaCardsbreast cancer sideroblastic anemia hepatitis b anemia alzheimer's disease hepatitis Human Genome Epidemiology (HuGE) Navigator: SFXN4 (3 documents) Export disorders for SFXN4 gene to outside databases
|
Publications for SFXN4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SFXN4 gene, integrated from 9 sources (see all 19): (articles sorted by number of sources associating them with SFXN4) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Molecular cloning and characterization of a novel human putative transmembrane protein homologous to mouse sideroflexin associated with sideroblastic anemia. (PubMed id 14756423)1, 2, 3, 9 Zheng H.... Mao Y. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
|
External Searches for SFXN4 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SFXN4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SFXN4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SFXN4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for SFXN4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SFXN4 gene: Search GeneIP for patents involving SFXN4
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for SFXN4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SFXN4 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SFXN4 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SFXN4 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SFXN4 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SFXN4 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SFXN4 |
| |
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| | | Search Tocris compounds for SFXN4 |
| |  |  |  |  | | | | |
 |
 |
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 | | SFXN4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFXN4 |
|  |  |  | | | Search ThermoFisher Antibodies for SFXN4 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFXN4 |
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