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Aliases for SFXN3 Gene

Aliases for SFXN3 Gene

  • Sideroflexin 3 2 3
  • Sideroflexin-3 3
  • BA108L7.2 3
  • SFX3 3

External Ids for SFXN3 Gene

Previous GeneCards Identifiers for SFXN3 Gene

  • GC00U991057
  • GC10P102781
  • GC10P096420

Summaries for SFXN3 Gene

GeneCards Summary for SFXN3 Gene

SFXN3 (Sideroflexin 3) is a Protein Coding gene. Among its related pathways are Validated targets of C-MYC transcriptional repression. GO annotations related to this gene include cation transmembrane transporter activity. An important paralog of this gene is SFXN4.

UniProtKB/Swiss-Prot for SFXN3 Gene

  • Potential iron transporter

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFXN3 Gene

Genomics for SFXN3 Gene

Regulatory Elements for SFXN3 Gene

Genomic Location for SFXN3 Gene

101,031,234 bp from pter
101,041,244 bp from pter
10,011 bases
Plus strand

Genomic View for SFXN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SFXN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFXN3 Gene

Proteins for SFXN3 Gene

  • Protein details for SFXN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q8NCJ0
    • Q9NTP4

    Protein attributes for SFXN3 Gene

    325 amino acids
    Molecular mass:
    35979 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SFXN3 Gene

Proteomics data for SFXN3 Gene at MOPED

Post-translational modifications for SFXN3 Gene

  • Ubiquitination at Lys75 and Lys173
  • Modification sites at PhosphoSitePlus

Other Protein References for SFXN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SFXN3 Gene

Domains for SFXN3 Gene

Gene Families for SFXN3 Gene

Protein Domains for SFXN3 Gene


Suggested Antigen Peptide Sequences for SFXN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sideroflexin family.
  • Belongs to the sideroflexin family.
genes like me logo Genes that share domains with SFXN3: view

Function for SFXN3 Gene

Molecular function for SFXN3 Gene

UniProtKB/Swiss-Prot Function:
Potential iron transporter

Gene Ontology (GO) - Molecular Function for SFXN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008324 cation transmembrane transporter activity --
GO:0015075 ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SFXN3: view

Phenotypes for SFXN3 Gene

genes like me logo Genes that share phenotypes with SFXN3: view

Animal Models for SFXN3 Gene

MGI Knock Outs for SFXN3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for SFXN3 Gene

Localization for SFXN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFXN3 Gene

Mitochondrion membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SFXN3 Gene COMPARTMENTS Subcellular localization image for SFXN3 gene
Compartment Confidence
mitochondrion 5
cytosol 2
peroxisome 2
nucleus 1

Gene Ontology (GO) - Cellular Components for SFXN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0031966 mitochondrial membrane IEA --
genes like me logo Genes that share ontologies with SFXN3: view

Pathways for SFXN3 Gene

genes like me logo Genes that share pathways with SFXN3: view

Pathways by source for SFXN3 Gene

1 BioSystems pathway for SFXN3 Gene

Interacting Proteins for SFXN3 Gene

Gene Ontology (GO) - Biological Process for SFXN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0034220 ion transmembrane transport IEA --
GO:0055072 iron ion homeostasis IEA --
GO:0055085 transmembrane transport --
GO:0098655 cation transmembrane transport --
genes like me logo Genes that share ontologies with SFXN3: view

Drugs for SFXN3 Gene

(1) HMDB Compounds for SFXN3 Gene

Compound Synonyms Cas Number PubMed IDs
  • Armco iron
genes like me logo Genes that share compounds with SFXN3: view

Transcripts for SFXN3 Gene

Unigene Clusters for SFXN3 Gene

Sideroflexin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SFXN3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5: - - - -
SP6: - - - - - - - -
SP7: -
SP8: -

Relevant External Links for SFXN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SFXN3 Gene

mRNA expression in normal human tissues for SFXN3 Gene

Protein differential expression in normal tissues for SFXN3 Gene

This gene is overexpressed in Nasal epithelium (15.6) and Bone (8.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SFXN3 Gene

SOURCE GeneReport for Unigene cluster for SFXN3 Gene Hs.283844

genes like me logo Genes that share expressions with SFXN3: view

Expression partners for SFXN3 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SFXN3 Gene

Orthologs for SFXN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SFXN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SFXN3 35
  • 90.13 (n)
  • 93.46 (a)
SFXN3 36
  • 93 (a)
(Canis familiaris)
Mammalia SFXN3 35
  • 91.59 (n)
  • 94.39 (a)
SFXN3 36
  • 94 (a)
(Mus musculus)
Mammalia Sfxn3 35
  • 88.47 (n)
  • 93.77 (a)
Sfxn3 16
Sfxn3 36
  • 94 (a)
(Pan troglodytes)
Mammalia SFXN3 35
  • 99.18 (n)
  • 98.77 (a)
SFXN3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Sfxn3 35
  • 87.64 (n)
  • 93.46 (a)
(Monodelphis domestica)
Mammalia SFXN3 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia SFXN3 36
  • 62 (a)
(Gallus gallus)
Aves SFXN3 36
  • 76 (a)
(Anolis carolinensis)
Reptilia SFXN3 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sfxn3 35
  • 70.53 (n)
  • 77.74 (a)
(Danio rerio)
Actinopterygii sfxn3 35
  • 70.62 (n)
  • 76.25 (a)
sfxn3 36
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11739 36
  • 54 (a)
(Caenorhabditis elegans)
Secernentea sfxn-1.4 35
  • 55.35 (n)
  • 54.4 (a)
sfxn-1.1 36
  • 47 (a)
sfxn-1.2 36
  • 46 (a)
sfxn-1.3 36
  • 46 (a)
sfxn-1.4 36
  • 52 (a)
sfxn-1.5 36
  • 52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FSF1 36
  • 38 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4566 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10377 36
  • 60 (a)
Species with no ortholog for SFXN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SFXN3 Gene

Gene Tree for SFXN3 (if available)
Gene Tree for SFXN3 (if available)

Paralogs for SFXN3 Gene

Paralogs for SFXN3 Gene

(3) SIMAP similar genes for SFXN3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SFXN3: view

Variants for SFXN3 Gene

Sequence variations from dbSNP and Humsavar for SFXN3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs3740498 -- 101,039,606(+) GTCCC(C/G)TCCCT utr-variant-3-prime
rs11190805 -- 101,041,517(+) ttttt(C/T)ttttt downstream-variant-500B
rs11539977 -- 101,039,925(+) AGCCT(A/C)ATGTC utr-variant-3-prime
rs12356481 -- 101,041,653(+) gctga(A/G)actac downstream-variant-500B
rs17855995 -- 101,035,669(+) ACAGG(A/C)AGGGT splice-donor-variant

Structural Variations from Database of Genomic Variants (DGV) for SFXN3 Gene

Variant ID Type Subtype PubMed ID
nsv831965 CNV Loss 17160897
nsv895963 CNV Loss 21882294
nsv7525 CNV Insertion 18451855

Relevant External Links for SFXN3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFXN3 Gene

Disorders for SFXN3 Gene

Relevant External Links for SFXN3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for SFXN3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SFXN3 Gene

Publications for SFXN3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for SFXN3 Gene

Sources for SFXN3 Gene

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