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Aliases for SFXN3 Gene

Aliases for SFXN3 Gene

  • Sideroflexin 3 2 3 5
  • BA108L7.2 3
  • SFX3 3

External Ids for SFXN3 Gene

Previous GeneCards Identifiers for SFXN3 Gene

  • GC00U991057
  • GC10P102781
  • GC10P096420

Summaries for SFXN3 Gene

GeneCards Summary for SFXN3 Gene

SFXN3 (Sideroflexin 3) is a Protein Coding gene. Among its related pathways are Validated targets of C-MYC transcriptional repression. GO annotations related to this gene include cation transmembrane transporter activity and ion transmembrane transporter activity. An important paralog of this gene is SFXN4.

UniProtKB/Swiss-Prot for SFXN3 Gene

  • Potential iron transporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFXN3 Gene

Genomics for SFXN3 Gene

Regulatory Elements for SFXN3 Gene

Promoters for SFXN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SFXN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SFXN3 Gene

Chromosome:
10
Start:
101,031,229 bp from pter
End:
101,041,244 bp from pter
Size:
10,016 bases
Orientation:
Plus strand

Genomic View for SFXN3 Gene

Genes around SFXN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFXN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFXN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFXN3 Gene

Proteins for SFXN3 Gene

  • Protein details for SFXN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWM7-SFXN3_HUMAN
    Recommended name:
    Sideroflexin-3
    Protein Accession:
    Q9BWM7
    Secondary Accessions:
    • Q8NCJ0
    • Q9NTP4

    Protein attributes for SFXN3 Gene

    Size:
    325 amino acids
    Molecular mass:
    35979 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SFXN3 Gene

Proteomics data for SFXN3 Gene at MOPED

Post-translational modifications for SFXN3 Gene

  • Ubiquitination at Lys 75 and Lys 173
  • Modification sites at PhosphoSitePlus

Other Protein References for SFXN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SFXN3 Gene

Domains & Families for SFXN3 Gene

Gene Families for SFXN3 Gene

Protein Domains for SFXN3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SFXN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BWM7

UniProtKB/Swiss-Prot:

SFXN3_HUMAN :
  • Belongs to the sideroflexin family.
Family:
  • Belongs to the sideroflexin family.
genes like me logo Genes that share domains with SFXN3: view

Function for SFXN3 Gene

Molecular function for SFXN3 Gene

UniProtKB/Swiss-Prot Function:
Potential iron transporter.
genes like me logo Genes that share phenotypes with SFXN3: view

Animal Models for SFXN3 Gene

MGI Knock Outs for SFXN3:

Animal Model Products

  • Taconic Biosciences Mouse Models for SFXN3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SFXN3 Gene

Localization for SFXN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFXN3 Gene

Mitochondrion membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SFXN3 Gene COMPARTMENTS Subcellular localization image for SFXN3 gene
Compartment Confidence
mitochondrion 5
cytosol 2
peroxisome 2
nucleus 1

Gene Ontology (GO) - Cellular Components for SFXN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SFXN3: view

Pathways & Interactions for SFXN3 Gene

genes like me logo Genes that share pathways with SFXN3: view

Pathways by source for SFXN3 Gene

1 BioSystems pathway for SFXN3 Gene

Interacting Proteins for SFXN3 Gene

Gene Ontology (GO) - Biological Process for SFXN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034220 ion transmembrane transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SFXN3: view

No data available for SIGNOR curated interactions for SFXN3 Gene

Drugs & Compounds for SFXN3 Gene

(1) Additional Compounds for SFXN3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
genes like me logo Genes that share compounds with SFXN3: view

Transcripts for SFXN3 Gene

Unigene Clusters for SFXN3 Gene

Sideroflexin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SFXN3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5: - - - -
SP6: - - - - - - - -
SP7: -
SP8: -
SP9:
SP10:

Relevant External Links for SFXN3 Gene

GeneLoc Exon Structure for
SFXN3
ECgene alternative splicing isoforms for
SFXN3

Expression for SFXN3 Gene

mRNA expression in normal human tissues for SFXN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SFXN3 Gene

This gene is overexpressed in Nasal epithelium (15.6) and Bone (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SFXN3 Gene



SOURCE GeneReport for Unigene cluster for SFXN3 Gene Hs.283844

genes like me logo Genes that share expression patterns with SFXN3: view

Protein tissue co-expression partners for SFXN3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SFXN3 Gene

Orthologs for SFXN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SFXN3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SFXN3 35
  • 90.13 (n)
  • 93.46 (a)
SFXN3 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SFXN3 35
  • 91.59 (n)
  • 94.39 (a)
SFXN3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sfxn3 35
  • 88.47 (n)
  • 93.77 (a)
Sfxn3 16
Sfxn3 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SFXN3 35
  • 99.18 (n)
  • 98.77 (a)
SFXN3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sfxn3 35
  • 87.64 (n)
  • 93.46 (a)
oppossum
(Monodelphis domestica)
Mammalia SFXN3 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SFXN3 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves SFXN3 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SFXN3 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sfxn3 35
  • 70.53 (n)
  • 77.74 (a)
zebrafish
(Danio rerio)
Actinopterygii sfxn3 35
  • 70.62 (n)
  • 76.25 (a)
sfxn3 36
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11739 36
  • 54 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sfxn-1.4 35
  • 55.35 (n)
  • 54.4 (a)
sfxn-1.1 36
  • 47 (a)
ManyToMany
sfxn-1.2 36
  • 46 (a)
ManyToMany
sfxn-1.3 36
  • 46 (a)
ManyToMany
sfxn-1.4 36
  • 52 (a)
ManyToMany
sfxn-1.5 36
  • 52 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FSF1 36
  • 38 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4566 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10377 36
  • 60 (a)
OneToMany
Species with no ortholog for SFXN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SFXN3 Gene

ENSEMBL:
Gene Tree for SFXN3 (if available)
TreeFam:
Gene Tree for SFXN3 (if available)

Paralogs for SFXN3 Gene

Paralogs for SFXN3 Gene

(3) SIMAP similar genes for SFXN3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SFXN3: view

Variants for SFXN3 Gene

Sequence variations from dbSNP and Humsavar for SFXN3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs807048 -- 101,040,603(-) TCCAT(C/T)AAAAA nc-transcript-variant, utr-variant-3-prime
rs807049 -- 101,038,589(-) CTGTC(A/G)CCCCA intron-variant, nc-transcript-variant
rs807050 -- 101,033,751(-) actac(G/T)acatt intron-variant
rs1141327 -- 101,040,638(+) agtgc(A/G)atggt nc-transcript-variant, utr-variant-3-prime
rs1064255 -- 101,039,734(+) GGTGG(A/G)GGAGG nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SFXN3 Gene

Variant ID Type Subtype PubMed ID
nsv831965 CNV Loss 17160897
nsv895963 CNV Loss 21882294
nsv7525 CNV Insertion 18451855

Variation tolerance for SFXN3 Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.27; 52.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SFXN3 Gene

HapMap Linkage Disequilibrium report
SFXN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFXN3 Gene

Disorders for SFXN3 Gene

Relevant External Links for SFXN3

Genetic Association Database (GAD)
SFXN3
Human Genome Epidemiology (HuGE) Navigator
SFXN3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SFXN3

No disorders were found for SFXN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SFXN3 Gene

Publications for SFXN3 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for SFXN3 Gene

Sources for SFXN3 Gene

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