SFXN3 Gene
protein-coding GIFtS: 49
GCID: GC10P102781
|
|
sideroflexin 3
| |
Aliases
for SFXN3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sideroflexin 31 2 | | SFX31 2 | | BA108L7.22 | | Sideroflexin-31 |
Export aliases for SFXN3 gene to outside databasesPrevious GC identifers: GC00U991057 GC10P096420 |
Summaries
for SFXN3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SFXN3_HUMAN, Q9BWM7Function: Potential iron transporter
|
Genomic Views
for SFXN3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SFXN3 gene promoter:
Bach1 RFX1 CUTL1 C/EBPalpha GATA-1 AREB6 PPAR-alpha PPAR-gamma1 c-Rel MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SFXN3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SFXN3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q24.31 Ensembl cytogenetic band: 10q24.31 HGNC cytogenetic band: 10q24.32SFXN3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P102781: view genomic region
(about GC identifiers)
Start:
|
102,790,991 bp from pter |
End:
|
102,800,998 bp from pter |
Size:
|
10,008 bases |
Orientation:
|
plus strand |
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Proteins
for SFXN3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SFXN3_HUMAN, Q9BWM7 (See
protein sequence)Recommended Name: Sideroflexin-3 Size: 325 amino acids; 35979 Da
Subcellular location: Mitochondrion membrane; Multi-pass membrane protein
Caution: It is uncertain whether Met-1 or Met-5 is the initiator
Secondary accessions: Q8NCJ0 Q9NTP4Explore the universe of human proteins at neXtProt for SFXN3: NX_Q9BWM7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BWM7
SFXN3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_112233.2
ENSEMBL proteins: ENSP00000377103 ENSP00000224807
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SFXN3 for ontologies About GeneDecksing
SFXN3 Antibody Products:
Assay Products for SFXN3: |
Protein
Domains /
Families
for SFXN3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SFXN3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BWM7ProtoNet protein and cluster: Q9BWM7 1 Blocks protein family: IPB004686 Tricarboxylate/iron carrier
UniProtKB/Swiss-Prot: SFXN3_HUMAN, Q9BWM7Similarity: Belongs to the sideroflexin family |
Function
for SFXN3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SFXN3_HUMAN, Q9BWM7Function: Potential iron transporter
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFXN3 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFXN3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SFXN3 (NM_030971) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SFXN3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFXN3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFXN3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008324 | cation transmembrane transporter activity |
IEA | -- |
SFXN3 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for SFXN3:
|
Pathways & Interactions
for SFXN3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Validated targets of C-MYC transcriptional repression | |
1  BioSystems Pathway for SFXN3
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SFXN3
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/11 Interacting proteins for SFXN3 (Q9BWM73 ENSP000002248074) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0055072 | iron ion homeostasis |
IEA | -- |
SFXN3 for ontologies About GeneDecksing
|
Drugs & Compounds
for SFXN3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SFXN3
1 HMDB Compound for SFXN3 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Iron | Armco iron (see all 19) | 7439-89-6 | -- |
Search CenterWatch for drugs/clinical trials and news about SFXN3
|
Transcripts
for SFXN3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SFXN3 gene: NM_030971.3 Unigene Cluster for SFXN3: Sideroflexin 3 Hs.283844 [show with all ESTs]Unigene Representative Sequence: AK0915047 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000393459(uc001ksp.3 uc010qpx.2) ENST00000489434 ENST00000465383
ENST00000487721 ENST00000466982 ENST00000470252 ENST00000224807
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFXN3 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFXN3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SFXN3 (NM_030971) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SFXN3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFXN3 |
Additional cDNA sequence: AK074707.1 AK091504.1 AK093011.1 AK299405.1 BC000124.1 13 DOTS entries: DT.100732820 DT.117566 DT.40114554 DT.121238733 DT.40244331 DT.99953089 DT.100716642 DT.121238784 DT.100781687 DT.121238778 DT.121238788 DT.95363720 DT.92447174 24/162 AceView cDNA sequences (see all 162): CO246073 T30448 T30958 BQ959114 BM451364 T31239 AA293453 CF125913 BC000124 CR614959 CD370488 BU184941 F01846 Z42317 NM_030971 BU617280 BG254227 BM772320 BQ223306 F08208 AI732397 BI908654 CA488624 F04451
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SFXN3 (see all 10) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | | | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SFXN3
|
Expression
for SFXN3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SFXN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCTCTGGCT
About this image
See SFXN3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SFXN3
SOURCE GeneReport for Unigene cluster: Hs.283844
SABiosciences Custom PCR Arrays for SFXN3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SFXN3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SFXN3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SFXN3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SFXN3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFXN3 |
Orthologs
for SFXN3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SFXN3 gene from 4/22 species (see all 22) About this table
ENSEMBL Gene Tree for SFXN3 (if available)
TreeFam Gene Tree for SFXN3 (if available) |
Paralogs
for SFXN3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SFXN3 gene
- SFXN42 SFXN12 SFXN52 SFXN22
3 SIMAP similar genes for SFXN3 using alignment to 1 protein entry: SFXN3_HUMAN:SFXN1 SFXN2 SFXN5
SFXN3 for paralogs About GeneDecksing
|
Genomic Variants
for SFXN3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SFXN3 (102790991 - 102800998 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SFXN3
1 CNV: 4711 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SFXN3 |
|
Disorders
/ Diseases
for SFXN3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SFXN3 for disorders About MalaCards
SFXN3 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: SFXN3 (1 document)
Export disorders for SFXN3 gene to outside databases
|
Publications
for SFXN3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SFXN3 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with SFXN3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (2005)
|
External Searches for SFXN3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SFXN3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SFXN3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SFXN3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SFXN3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SFXN3 gene:
Search GeneIP for patents involving SFXN3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SFXN3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SFXN3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SFXN3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SFXN3 | | | OriGene Protein Over-expression Lysate for SFXN3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SFXN3 | | OriGene 3'-UTR Clone for SFXN3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFXN3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFXN3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SFXN3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SFXN3 | | OriGene Custom Protein Services for SFXN3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SFXN3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SFXN3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SFXN3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SFXN3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SFXN3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SFXN3 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for SFXN3 |
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 | | | SFXN3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFXN3 |
|  |  |  | | | | Search ThermoFisher Antibodies for SFXN3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFXN3 |
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