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Aliases for SFXN3 Gene

Aliases for SFXN3 Gene

  • Sideroflexin 3 2 3 5
  • Sideroflexin-3 3
  • BA108L7.2 3
  • SFX3 3

External Ids for SFXN3 Gene

Previous GeneCards Identifiers for SFXN3 Gene

  • GC00U991057
  • GC10P102781
  • GC10P096420

Summaries for SFXN3 Gene

GeneCards Summary for SFXN3 Gene

SFXN3 (Sideroflexin 3) is a Protein Coding gene. Among its related pathways are Validated targets of C-MYC transcriptional repression. GO annotations related to this gene include cation transmembrane transporter activity and ion transmembrane transporter activity. An important paralog of this gene is SFXN1.

UniProtKB/Swiss-Prot for SFXN3 Gene

  • Potential iron transporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFXN3 Gene

Genomics for SFXN3 Gene

Regulatory Elements for SFXN3 Gene

Enhancers for SFXN3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SFXN3 on UCSC Golden Path with GeneCards custom track

Promoters for SFXN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SFXN3 Gene

101,031,229 bp from pter
101,041,244 bp from pter
10,016 bases
Plus strand

Genomic View for SFXN3 Gene

Genes around SFXN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFXN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFXN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFXN3 Gene

Proteins for SFXN3 Gene

  • Protein details for SFXN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q8NCJ0
    • Q9NTP4

    Protein attributes for SFXN3 Gene

    325 amino acids
    Molecular mass:
    35979 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SFXN3 Gene

Post-translational modifications for SFXN3 Gene

  • Ubiquitination at Lys 75 and Lys 173
  • Modification sites at PhosphoSitePlus

Other Protein References for SFXN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SFXN3 Gene

Domains & Families for SFXN3 Gene

Gene Families for SFXN3 Gene

Protein Domains for SFXN3 Gene


Suggested Antigen Peptide Sequences for SFXN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sideroflexin family.
  • Belongs to the sideroflexin family.
genes like me logo Genes that share domains with SFXN3: view

Function for SFXN3 Gene

Molecular function for SFXN3 Gene

UniProtKB/Swiss-Prot Function:
Potential iron transporter.

Gene Ontology (GO) - Molecular Function for SFXN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015075 ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SFXN3: view
genes like me logo Genes that share phenotypes with SFXN3: view

Animal Models for SFXN3 Gene

MGI Knock Outs for SFXN3:

Animal Model Products

  • Taconic Biosciences Mouse Models for SFXN3

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SFXN3 Gene

Localization for SFXN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFXN3 Gene

Mitochondrion membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SFXN3 Gene COMPARTMENTS Subcellular localization image for SFXN3 gene
Compartment Confidence
mitochondrion 5
cytosol 2
peroxisome 2
nucleus 1

Gene Ontology (GO) - Cellular Components for SFXN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0016021 integral component of membrane IEA --
GO:0031966 mitochondrial membrane IEA --
genes like me logo Genes that share ontologies with SFXN3: view

Pathways & Interactions for SFXN3 Gene

genes like me logo Genes that share pathways with SFXN3: view

Pathways by source for SFXN3 Gene

1 BioSystems pathway for SFXN3 Gene

Gene Ontology (GO) - Biological Process for SFXN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034220 ion transmembrane transport IEA --
GO:0055072 iron ion homeostasis IEA --
genes like me logo Genes that share ontologies with SFXN3: view

No data available for SIGNOR curated interactions for SFXN3 Gene

Drugs & Compounds for SFXN3 Gene

(1) Additional Compounds for SFXN3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
genes like me logo Genes that share compounds with SFXN3: view

Transcripts for SFXN3 Gene

Unigene Clusters for SFXN3 Gene

Sideroflexin 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SFXN3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5: - - - -
SP6: - - - - - - - -
SP7: -
SP8: -

Relevant External Links for SFXN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SFXN3 Gene

mRNA expression in normal human tissues for SFXN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SFXN3 Gene

This gene is overexpressed in Nasal epithelium (15.6) and Bone (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SFXN3 Gene

Protein tissue co-expression partners for SFXN3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SFXN3 Gene:


SOURCE GeneReport for Unigene cluster for SFXN3 Gene:

genes like me logo Genes that share expression patterns with SFXN3: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SFXN3 Gene

Orthologs for SFXN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SFXN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SFXN3 34
  • 90.13 (n)
  • 93.46 (a)
SFXN3 35
  • 93 (a)
(Canis familiaris)
Mammalia SFXN3 34
  • 91.59 (n)
  • 94.39 (a)
SFXN3 35
  • 94 (a)
(Mus musculus)
Mammalia Sfxn3 34
  • 88.47 (n)
  • 93.77 (a)
Sfxn3 16
Sfxn3 35
  • 94 (a)
(Pan troglodytes)
Mammalia SFXN3 34
  • 99.18 (n)
  • 98.77 (a)
SFXN3 35
  • 99 (a)
(Rattus norvegicus)
Mammalia Sfxn3 34
  • 87.64 (n)
  • 93.46 (a)
(Monodelphis domestica)
Mammalia SFXN3 35
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia SFXN3 35
  • 62 (a)
(Gallus gallus)
Aves SFXN3 35
  • 76 (a)
(Anolis carolinensis)
Reptilia SFXN3 35
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sfxn3 34
  • 70.53 (n)
  • 77.74 (a)
(Danio rerio)
Actinopterygii sfxn3 34
  • 70.62 (n)
  • 76.25 (a)
sfxn3 35
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11739 35
  • 54 (a)
(Caenorhabditis elegans)
Secernentea sfxn-1.4 34
  • 55.35 (n)
  • 54.4 (a)
sfxn-1.1 35
  • 47 (a)
sfxn-1.2 35
  • 46 (a)
sfxn-1.3 35
  • 46 (a)
sfxn-1.4 35
  • 52 (a)
sfxn-1.5 35
  • 52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FSF1 35
  • 38 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4566 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10377 35
  • 60 (a)
Species where no ortholog for SFXN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SFXN3 Gene

Gene Tree for SFXN3 (if available)
Gene Tree for SFXN3 (if available)

Paralogs for SFXN3 Gene

Paralogs for SFXN3 Gene

(3) SIMAP similar genes for SFXN3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SFXN3: view

Variants for SFXN3 Gene

Sequence variations from dbSNP and Humsavar for SFXN3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs3740498 -- 101,039,606(+) GTCCC(C/G)TCCCT nc-transcript-variant, utr-variant-3-prime
rs807048 -- 101,040,603(-) TCCAT(C/T)AAAAA nc-transcript-variant, utr-variant-3-prime
rs807049 -- 101,038,589(-) CTGTC(A/G)CCCCA intron-variant, nc-transcript-variant
rs807050 -- 101,033,751(-) actac(G/T)acatt intron-variant
rs2275382 -- 101,037,502(-) CTGGA(A/G)AGAGA intron-variant, nc-transcript-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SFXN3 Gene

Variant ID Type Subtype PubMed ID
esv3624367 CNV loss 21293372
nsv476347 CNV novel sequence insertion 20440878
nsv7525 CNV insertion 18451855
nsv831965 CNV loss 17160897

Variation tolerance for SFXN3 Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.27; 52.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SFXN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFXN3 Gene

Disorders for SFXN3 Gene

Relevant External Links for SFXN3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SFXN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SFXN3 Gene

Publications for SFXN3 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd B.J. … Pagliarini D.J. (Mol. Cell 2016) 3 65
  4. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3 65
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 65

Products for SFXN3 Gene

Sources for SFXN3 Gene

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