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SFXN2 Gene

protein-coding   GIFtS: 55
GCID: GC10P104464

Sideroflexin 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sideroflexin 21 2
sideroflexin-22

External Ids:    HGNC: 160861   Entrez Gene: 1189802   Ensembl: ENSG000001563987   OMIM: 6155705   UniProtKB: Q96NB23   

Export aliases for SFXN2 gene to outside databases

Previous GC identifers: GC10P103367 GC10P103707 GC10P104605 GC10P104138 GC10P098108


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SFXN2 Gene:
SFXN2 (sideroflexin 2) is a protein-coding gene. GO annotations related to this gene include cation transmembrane transporter activity. An important paralog of this gene is SFXN4.

UniProtKB/Swiss-Prot: SFXN2_HUMAN, Q96NB2
Function: Potential iron transporter




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SFXN2 gene promoter:
         AhR   Bach1   TBP   NF-1   NF-1/L   RREB-1   Cdc5   Egr-4   Egr-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSFXN2 promoter sequence
   Search Chromatin IP Primers for SFXN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SFXN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.32   Ensembl cytogenetic band:  10q24.32   HGNC cytogenetic band: 10q24.32

SFXN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SFXN2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P104464:  view genomic region     (about GC identifiers)

Start:
104,474,295 bp from pter      End:
104,503,249 bp from pter
Size:
28,955 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SFXN2_HUMAN, Q96NB2 (See protein sequence)
Recommended Name: Sideroflexin-2  
Size: 322 amino acids; 36232 Da
Sequence caution: Sequence=BAB70993.1; Type=Erroneous initiation;
Secondary accessions: Q5JSM6

Explore the universe of human proteins at neXtProt for SFXN2: NX_Q96NB2

Explore proteomics data for SFXN2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys25, Lys308
  • Modification sites at PhosphoSitePlus

  • See SFXN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_849189.1  
    ENSEMBL proteins: 
     ENSP00000473573   ENSP00000358909   ENSP00000473504   ENSP00000473316   ENSP00000473392  
     ENSP00000473578   ENSP00000473518   ENSP00000473325   ENSP00000473329   ENSP00000473374  

    SFXN2 Human Recombinant Protein Products:

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    Novus Biologicals SFXN2 Protein
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for SFXN2

     
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    antibodies-online proteins for SFXN2 (2 products) 

     
    antibodies-online peptides for SFXN2

    SFXN2 Antibody Products:

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    antibodies-online antibodies for SFXN2 (7 products) 

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    antibodies-online kits for SFXN2 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SFXN: Sideroflexins

    1 InterPro protein domain:
     IPR004686 Mtc

    Graphical View of Domain Structure for InterPro Entry Q96NB2

    ProtoNet protein and cluster: Q96NB2

    1 Blocks protein domain: IPB004686 Tricarboxylate/iron carrier

    UniProtKB/Swiss-Prot: SFXN2_HUMAN, Q96NB2
    Similarity: Belongs to the sideroflexin family


    Find genes that share domains with SFXN2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SFXN2_HUMAN, Q96NB2
    Function: Potential iron transporter

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008324cation transmembrane transporter activity IEA--
         
    Find genes that share ontologies with SFXN2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for SFXN2:
     Decreased influenza A virus in  Increased TP53 protein express  Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SFXN2

    miRNA
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    miRTarBase miRNAs that target SFXN2:
    hsa-mir-128-3p (MIRT022080), hsa-mir-132-3p (MIRT021800), hsa-mir-193b-3p (MIRT016460)

    Block miRNA regulation of human, mouse, rat SFXN2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SFXN2 (see all 23):
    hsa-miR-623 hsa-miR-3685 hsa-miR-1321 hsa-miR-502-5p hsa-miR-539 hsa-miR-128 hsa-miR-650 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidSFXN2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SFXN2
    Predesigned siRNA for gene silencing in human, mouse, rat SFXN2

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for SFXN2 (see all 6)
    OriGene ORF clones in mouse, rat for SFXN2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SFXN2 (NM_178858)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SFXN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFXN2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SFXN2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFXN2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SFXN2_HUMAN, Q96NB2: Mitochondrion membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    peroxisome2
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005743mitochondrial inner membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SFXN2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SFXN2
    Interactions:

        Search GeneGlobe Interaction Network for SFXN2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for SFXN2 (Q96NB23 ENSP000003589094) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLN3Q132863I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006812cation transport ----
    GO:0055072iron ion homeostasis IEA--
    GO:0055085transmembrane transport ----

    Find genes that share ontologies with SFXN2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SFXN2

    1 HMDB Compound for SFXN2    About this table
    CompoundSynonyms CAS #PubMed Ids
    IronArmco iron (see all 19)7439-89-6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SFXN2 gene: 
    NM_178858.4  

    Unigene Cluster for SFXN2:

    Sideroflexin 2
    Hs.44070  [show with all ESTs]
    Unigene Representative Sequence: BC022091
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000602831 ENST00000369893(uc001kwb.2 uc001kwc.2) ENST00000602287
    ENST00000480358 ENST00000602544 ENST00000602647 ENST00000602785 ENST00000602439
    ENST00000602764 ENST00000459894 ENST00000602670 ENST00000602660 ENST00000602868

    miRNA
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    Block miRNA regulation of human, mouse, rat SFXN2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SFXN2 (see all 23):
    hsa-miR-623 hsa-miR-3685 hsa-miR-1321 hsa-miR-502-5p hsa-miR-539 hsa-miR-128 hsa-miR-650 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidSFXN2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SFXN2
    Predesigned siRNA for gene silencing in human, mouse, rat SFXN2
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    OriGene clones in human, mouse for SFXN2 (see all 6)
    OriGene ORF clones in mouse, rat for SFXN2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SFXN2 (NM_178858)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SFXN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFXN2
    Primer
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    OriGene qPCR primer pairs and template standards for SFXN2
    OriGene qSTAR qPCR primer pairs in human, mouse for SFXN2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SFXN2
      QuantiTect SYBR Green Assays in human, mouse, rat SFXN2
      QuantiFast Probe-based Assays in human, mouse, rat SFXN2

    Additional mRNA sequence: 

    AF462052.1 AK308246.1 BC022091.2 

    10 DOTS entries:

    DT.314537  DT.92069123  DT.121642604  DT.102825440  DT.40188814  DT.121213741  DT.100774592  DT.121213745 
    DT.75172333  DT.92051672 

    Selected AceView cDNA sequences (see all 118):

    AA989363 AI049571 BM833015 AA557277 BP873601 BM697684 BP872052 AA496126 
    CR616223 AA476258 BP871559 BP872141 CA445823 AA894829 BF194923 BP871592 
    BM991011 BX090573 AI168025 BQ082296 AA887308 AK055711 N56615 BP872233 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SFXN2 (see all 15)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e · 10f ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^
    SP1:        -     -     -     -     -     -     -                                   -     -                                   -     -     -           -     -   
    SP2:        -     -     -     -     -     -     -     -                             -     -                                   -                                 
    SP3:                                                                                                                                                            
    SP4:        -     -     -     -     -     -     -     -                                                                                                         
    SP5:        -     -     -     -     -     -     -     -                             -     -                                   -     -     -                     

    ExUns: 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for SFXN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SFXN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGAACCTA
    SFXN2 Expression
    About this image


    SFXN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Kidney (Urinary System)
    SFXN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SFXN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.44070

    UniProtKB/Swiss-Prot: SFXN2_HUMAN, Q96NB2
    Tissue specificity: Widely expressed, highest levels in kidney, liver, and pancreas

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFXN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SFXN2 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sfxn21 , 5 sideroflexin 21, 5 86.34(n)1
    89.13(a)1
      19 (38.96 cM)5
    942791  NM_053196.31  NP_444426.31 
     465733655 
    chicken
    (Gallus gallus)
    Aves SFXN21 sideroflexin 2 73.52(n)
    75(a)
      423866  XM_004942243.1  XP_004942300.1 
    lizard
    (Anolis carolinensis)
    Reptilia SFXN26
    sideroflexin 2
    60(a)
    1 ↔ 1
    3(40102156-40140922)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC691442 hypothetical protein MGC69144 71.68(n)    BC056118.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa03a092 Danio rerio mRNA similar to sideroflexin 2 (cDNA clone more 74.15(n)    BC048044.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG68121 , 3 CG68121 53(a)
    (best of 2)3
    60.19(n)1
    58.28(a)1
      75F63
    400801  NM_140829.31  NP_649086.21 
    worm
    (Caenorhabditis elegans)
    Secernentea T04F8.13
    sfxn-21
    sfxn-21 49(a)
    (best of 6)3
    51.82(n)1
    48.4(a)1
      X(11694958-11696884)3
    1810541  NM_076940.51  NP_509341.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FSF16
    Putative protein, predicted to be an alpha-isoprop...
    32(a)
    1 → many
    XV(831059-832042) YOR271C


    ENSEMBL Gene Tree for SFXN2 (if available)
    TreeFam Gene Tree for SFXN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SFXN2 gene
    SFXN42  SFXN12  SFXN52  SFXN32  
    3 SIMAP similar genes for SFXN2 using alignment to 8 protein entries:     SFXN2_HUMAN (see all proteins):
    SFXN1    SFXN3    SFXN5

    Find genes that share paralogs with SFXN2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SFXN2 (see all 483)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2001177681,2
    C--104476285(+) ATTAC-/TTTTTT 1 -- int10--------
    rs79054811,2
    C,F--104476292(+) TTTTTT/CTCTCT 1 -- int1 trp38Minor allele frequency- C:0.25NA CSA WA EA 368
    rs560714571,2
    --104476293(+) TTTTTC/TCTCTT 1 -- int10--------
    rs1832837501,2
    --104476384(+) GCAACA/GGTGCG 1 -- int10--------
    rs1379575191,2
    --104476541(+) GGCTGG/TTCTTG 1 -- int10--------
    rs1126775681,2
    C--104476562(+) CTCAGG/ATGATC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1881584121,2
    --104476581(+) TTGGGC/TTCTCA 1 -- int10--------
    rs1419678601,2
    C--104476615(+) GCCACC/TGTGCC 1 -- int10--------
    rs1917954311,2
    --104476627(+) GGCCTC/GGGAGT 1 -- int10--------
    rs1142901731,2
    C,F--104476662(+) AGGACC/TTTGGG 1 -- int11Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for SFXN2 (104474295 - 104503249 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SFXN2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv999356CNV Loss20482838
    nsv831969CNV Loss17160897
    nsv820242CNV Gain19587683

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615570    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for SFXN2:
    Sideroblastic anemia

    Find genes that share disorders with SFXN2           About GenesLikeMe

    Genetic Association Database (GAD): SFXN2
    Human Genome Epidemiology (HuGE) Navigator: SFXN2 (2 documents)

    Export disorders for SFXN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SFXN2 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with SFXN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    2. Genome-wide association study reveals genetic risk underlying Parkinson's disease. (PubMed id 19915575)1, 4 SimA^n-SA!nchez J....Gasser T. (Nat. Genet. 2009)
    3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Isolation and characterization of a novel human putative anemia- related gene homologous to mouse sideroflexin. (PubMed id 12670026)1, 2 Ye X.... Mao Y. (Biochem. Genet. 2003)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)
    9. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    10. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PubMed id 23974872)1 Ripke S....Sullivan P.F. (Nat. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 118980 HGNC: 16086 AceView: SFXN2 Ensembl:ENSG00000156398 euGenes: HUgn118980
    ECgene: SFXN2 H-InvDB: SFXN2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SFXN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SFXN2 gene:
    Search GeneIP for patents involving SFXN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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