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Aliases for SFXN2 Gene

Aliases for SFXN2 Gene

  • Sideroflexin 2 2 3
  • Sideroflexin-2 3

External Ids for SFXN2 Gene

Summaries for SFXN2 Gene

GeneCards Summary for SFXN2 Gene

SFXN2 (Sideroflexin 2) is a Protein Coding gene. GO annotations related to this gene include cation transmembrane transporter activity. An important paralog of this gene is SFXN4.

UniProtKB/Swiss-Prot for SFXN2 Gene

  • Potential iron transporter

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFXN2 Gene

Genomics for SFXN2 Gene

Genomic Location for SFXN2 Gene

Start:
102,714,538 bp from pter
End:
102,743,492 bp from pter
Size:
28,955 bases
Orientation:
Plus strand

Genomic View for SFXN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SFXN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFXN2 Gene

Regulatory Elements for SFXN2 Gene

Proteins for SFXN2 Gene

  • Protein details for SFXN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NB2-SFXN2_HUMAN
    Recommended name:
    Sideroflexin-2
    Protein Accession:
    Q96NB2
    Secondary Accessions:
    • Q5JSM6

    Protein attributes for SFXN2 Gene

    Size:
    322 amino acids
    Molecular mass:
    36232 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB70993.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SFXN2 Gene

Proteomics data for SFXN2 Gene at MOPED

Post-translational modifications for SFXN2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys25 and Lys308

No data available for DME Specific Peptides for SFXN2 Gene

Domains for SFXN2 Gene

Gene Families for SFXN2 Gene

HGNC:
  • SFXN :Sideroflexins

Protein Domains for SFXN2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SFXN2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96NB2

UniProtKB/Swiss-Prot:

SFXN2_HUMAN
Family:
  • Belongs to the sideroflexin family.:
    • Q96NB2
genes like me logo Genes that share domains with SFXN2: view

Function for SFXN2 Gene

Molecular function for SFXN2 Gene

UniProtKB/Swiss-Prot Function: Potential iron transporter

Gene Ontology (GO) - Molecular Function for SFXN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008324 cation transmembrane transporter activity --
GO:0015075 ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SFXN2: view
genes like me logo Genes that share phenotypes with SFXN2: view

miRNA for SFXN2 Gene

miRTarBase miRNAs that target SFXN2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SFXN2 Gene

Localization for SFXN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFXN2 Gene

Mitochondrion membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SFXN2 Gene COMPARTMENTS Subcellular localization image for SFXN2 gene
Compartment Confidence
mitochondrion 5
cytosol 2
peroxisome 2
nucleus 1

Gene Ontology (GO) - Cellular Components for SFXN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SFXN2: view

Pathways for SFXN2 Gene

SuperPathways for SFXN2 Gene

No Data Available

Interacting Proteins for SFXN2 Gene

Gene Ontology (GO) - Biological Process for SFXN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0034220 ion transmembrane transport IEA --
GO:0055072 iron ion homeostasis IEA --
GO:0055085 transmembrane transport --
GO:0098655 cation transmembrane transport --
genes like me logo Genes that share ontologies with SFXN2: view

No data available for Pathways by source for SFXN2 Gene

Compounds for SFXN2 Gene

(1) HMDB Compounds for SFXN2 Gene

Compound Synonyms Cas Number PubMed IDs
Iron
  • Armco iron
7439-89-6
genes like me logo Genes that share compounds with SFXN2: view

Transcripts for SFXN2 Gene

Unigene Clusters for SFXN2 Gene

Sideroflexin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SFXN2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e · 10f ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3:
SP4: - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - - -
SP10: - - - - -
SP11: - - - - -
SP12: - - - -
SP13: - - - - - - - - - -
SP14: -
SP15: - - - -

ExUns: 15 ^ 16 ^ 17 ^ 18a · 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for SFXN2 Gene

GeneLoc Exon Structure for
SFXN2
ECgene alternative splicing isoforms for
SFXN2

Expression for SFXN2 Gene

mRNA expression in normal human tissues for SFXN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SFXN2 Gene

This gene is overexpressed in Kidney - Cortex (5.9) and Liver (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SFXN2 Gene

SOURCE GeneReport for Unigene cluster for SFXN2 Gene Hs.44070

mRNA Expression by UniProt/SwissProt for SFXN2 Gene

Q96NB2-SFXN2_HUMAN
Tissue specificity: Widely expressed, highest levels in kidney, liver, and pancreas.
genes like me logo Genes that share expressions with SFXN2: view

Orthologs for SFXN2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SFXN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SFXN2 35
  • 99.59 (n)
  • 99.69 (a)
SFXN2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SFXN2 35
  • 88.82 (n)
  • 91.3 (a)
SFXN2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SFXN2 35
  • 91.41 (n)
  • 94.41 (a)
SFXN2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sfxn2 35
  • 86.34 (n)
  • 89.13 (a)
Sfxn2 16
Sfxn2 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SFXN2 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SFXN2 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910912 35
  • 87.37 (n)
  • 91.92 (a)
chicken
(Gallus gallus)
Aves SFXN2 35
  • 73.52 (n)
  • 75 (a)
SFXN2 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SFXN2 36
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC69144 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sfxn2 35
  • 68.32 (n)
  • 73.29 (a)
Str.20013 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9550 35
zebrafish
(Danio rerio)
Actinopterygii sfxn2 35
  • 69.47 (n)
  • 71.65 (a)
sfxn2 36
  • 71 (a)
OneToOne
wufa03a09 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007119 35
  • 60.9 (n)
  • 58.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6812 35
  • 60.19 (n)
  • 58.28 (a)
CG6812 36
  • 56 (a)
OneToOne
CG11739 37
  • 49 (a)
CG6812 37
  • 53 (a)
worm
(Caenorhabditis elegans)
Secernentea sfxn-2 35
  • 51.82 (n)
  • 48.4 (a)
sfxn-2 36
  • 47 (a)
OneToOne
T04F8.1 37
  • 49 (a)
AH6.2 37
  • 44 (a)
C14F5.4 37
  • 47 (a)
C47D12.3 37
  • 48 (a)
Y6E2A.9 37
  • 43 (a)
F37H8.4 37
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FSF1 36
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToOne
Species with no ortholog for SFXN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SFXN2 Gene

ENSEMBL:
Gene Tree for SFXN2 (if available)
TreeFam:
Gene Tree for SFXN2 (if available)

Paralogs for SFXN2 Gene

Paralogs for SFXN2 Gene

Selected SIMAP similar genes for SFXN2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SFXN2: view

Variants for SFXN2 Gene

Sequence variations from dbSNP and Humsavar for SFXN2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1129600 -- 102,738,539(+) TGATC(A/C/T)GCCCG utr-variant-3-prime, nc-transcript-variant
rs1475644 -- 102,731,407(+) gccag(A/G)atgat intron-variant
rs1475645 -- 102,718,446(+) CTCTT(G/T)CCCCT intron-variant
rs2244254 -- 102,729,254(-) GGCTT(C/G)AGGGA intron-variant
rs2244257 -- 102,729,157(-) AGTGC(C/T)CCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SFXN2 Gene

Variant ID Type Subtype PubMed ID
nsv831969 CNV Loss 17160897
nsv820242 CNV Gain 19587683
esv999356 CNV Loss 20482838

Relevant External Links for SFXN2 Gene

HapMap Linkage Disequilibrium report
SFXN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFXN2 Gene

Disorders for SFXN2 Gene

(1) University of Copenhagen DISEASES for SFXN2 Gene

Relevant External Links for SFXN2

Genetic Association Database (GAD)
SFXN2
Human Genome Epidemiology (HuGE) Navigator
SFXN2
genes like me logo Genes that share disorders with SFXN2: view

No data available for UniProtKB/Swiss-Prot for SFXN2 Gene

Publications for SFXN2 Gene

  1. Isolation and characterization of a novel human putative anemia- related gene homologous to mouse sideroflexin. (PMID: 12670026) Ye X. … Mao Y. (Biochem. Genet. 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  5. Genome-wide association study reveals genetic risk underlying Parkinson's disease. (PMID: 19915575) SimA^n-SA!nchez J. … Gasser T. (Nat. Genet. 2009) 3 48

Products for SFXN2 Gene

Sources for SFXN2 Gene

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