SFXN2 Gene
protein-coding GIFtS: 50
GCID: GC10P104464
|
|
sideroflexin 2
| |
Aliases for SFXN2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Sideroflexin 21 2 | | Sideroflexin-21 |
Export aliases for SFXN2 gene to outside databasesPrevious GC identifers: GC10P103367 GC10P103707 GC10P104605 GC10P104138 GC10P098108 |
Summaries for SFXN2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: SFXN2_HUMAN, Q96NB2Function: Potential iron transporter
|
Genomic Views for SFXN2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SFXN2 gene promoter: AhR Bach1 TBP NF-1 NF-1/L RREB-1 Cdc5 Egr-4 Egr-2 Other transcription factors
Search SABiosciences Chromatin IP Primers for SFXN2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SFXN2 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q24.32 Ensembl cytogenetic band: 10q24.32 HGNC cytogenetic band: 10q24.32SFXN2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P104464: view genomic region
(about GC identifiers)
Start:
|
104,474,297 bp from pter |
End:
|
104,498,951 bp from pter |
Size:
|
24,655 bases |
Orientation:
|
plus strand |
|
Proteins for SFXN2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: SFXN2_HUMAN, Q96NB2 (See
protein sequence)Recommended Name: Sideroflexin-2 Size: 322 amino acids; 36232 Da
Subcellular location: Mitochondrion membrane; Multi-pass membrane protein (By similarity)
Sequence caution: Sequence=BAB70993.1; Type=Erroneous initiation;Explore the universe of human proteins at neXtProt for SFXN2: NX_Q96NB2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96NB2 SFXN2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_849189.1 ENSEMBL proteins: ENSP00000358909 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005743 | mitochondrial inner membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
SFXN2 for ontologies About GeneDecksing
SFXN2 Antibody Products: Assay Products for SFXN2: |
Protein
Domains / Families for SFXN2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SFXN2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96NB2ProtoNet protein and cluster: Q96NB2 1 Blocks protein family: IPB004686 Tricarboxylate/iron carrier
UniProtKB/Swiss-Prot: SFXN2_HUMAN, Q96NB2Similarity: Belongs to the sideroflexin family |
Function for SFXN2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: SFXN2_HUMAN, Q96NB2Function: Potential iron transporter
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFXN2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFXN2 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SFXN2 (NM_178858) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SFXN2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFXN2  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFXN2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008324 | cation transmembrane transporter activity |
IEA | -- |
SFXN2 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for SFXN2:
|
Pathways & Interactions for SFXN2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SFXN2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
 2 Interacting proteins for SFXN2 (Q96NB23 ENSP000003589094) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0055072 | iron ion homeostasis |
IEA | -- |
SFXN2 for ontologies About GeneDecksing
|
Drugs & Compounds for SFXN2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for SFXN2
1 HMDB Compound for SFXN2 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Iron | Armco iron (see all 19) | 7439-89-6 | -- | Search CenterWatch for drugs/clinical trials and news about SFXN2 
|
Transcripts for SFXN2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for SFXN2 gene: NM_178858.4 Unigene Cluster for SFXN2: Sideroflexin 2 Hs.44070 [show with all ESTs]Unigene Representative Sequence: BC0220914 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369893(uc001kwb.2 uc001kwc.2) ENST00000459894 ENST00000473178 ENST00000480358
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFXN2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFXN2 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SFXN2 (NM_178858) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SFXN2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFXN2  |
Additional cDNA sequence: AF462052.1 AK308246.1 BC022091.2 10 DOTS entries: DT.314537 DT.92069123 DT.121642604 DT.102825440 DT.40188814 DT.121213741 DT.100774592 DT.121213745 DT.75172333 DT.92051672 24/118 AceView cDNA sequences (see all 118): BF194923 BX090573 BM833015 N56615 AI049571 AI168025 BQ082296 BP872141 AA557277 AK055711 BP872052 AA894829 CR616223 BP872285 BP873601 AA887308 AA476258 BP871592 BM697684 AA989363 BP871559 CA445823 BP872233 AA496126 GeneLoc Exon Structure
5/15 Alternative Splicing Database (ASD) splice patterns (SP) for SFXN2 (see all 15) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | · | 10f | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | |
| SP1: | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | - |   | - |   | |
| SP2: | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   |
| ExUns: | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | |
| SP1: | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for SFXN2
|
Expression for SFXN2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SFXN2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TCTGAACCTA
About this image See SFXN2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SFXN2
SOURCE GeneReport for Unigene cluster: Hs.44070 SABiosciences Custom PCR Arrays for SFXN2
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SFXN2 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SFXN2 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SFXN2 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SFXN2 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFXN2 |
Orthologs for SFXN2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SFXN2 gene from 6/24 species (see all 24) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
SFXN21 |
sideroflexin 2 |
73.31(n) 74.68(a) |
  |
423866 XM_421731.3 XP_421731.1 |
lizard (Anolis carolinensis) |
Reptilia |
SFXN26 |
-- |
70(a) |
1 ↔ 1 |
3(40115142-40140922) |
African clawed frog (Xenopus laevis) |
Amphibia |
MGC691442 |
hypothetical protein MGC69144 |
71.68(n) |
  |
BC056118.1 |
zebrafish (Danio rerio) |
Actinopterygii |
wufa03a092 |
Danio rerio mRNA similar to sideroflexin 2 (cDNA clone more |
74.15(n) |
  |
BC048044.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
CG68121 , 3 |
CG68121 |
53(a) (best of 2)3 60.4(n)1 58.28(a)1 |
  |
75F63 400801 NM_140829.21 NP_649086.21 |
worm (Caenorhabditis elegans) |
Secernentea |
T04F8.13 sfxn-21 |
Protein SFXN-21 |
49(a) (best of 6)3 51.88(n)1 48.55(a)1 |
  |
X(11694958-11696884)3 1810541 NM_076940.41 NP_509341.21 |
ENSEMBL Gene Tree for SFXN2 (if available) TreeFam Gene Tree for SFXN2 (if available)  |
Paralogs for SFXN2 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for SFXN2 gene
- SFXN42 SFXN12 SFXN52 SFXN32
3 SIMAP similar genes for SFXN2 using alignment to 2 protein entries: SFXN2_HUMAN (see all proteins):SFXN1 SFXN3 SFXN5
SFXN2 for paralogs About GeneDecksing
|
Genomic Variants for SFXN2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 10 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for SFXN2 (104474297 - 104498951 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for SFXN2 1 CNV: 58417  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SFXN2 |
|
Disorders
/ Diseases for SFXN2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SFXN2 for disorders About GeneDecksing
4 diseases for SFXN2: About MalaCardssideroblastic anemia parkinson's disease anemia alzheimer's disease 1 disease from the University of Copenhagen DISEASES database for SFXN2:Sideroblastic anemia Human Genome Epidemiology (HuGE) Navigator: SFXN2 (2 documents) Export disorders for SFXN2 gene to outside databases
|
Publications for SFXN2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SFXN2 gene, integrated from 9 sources (see all 12): (articles sorted by number of sources associating them with SFXN2) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Genome-wide association study reveals genetic risk un derlying Parkinson's disease. (PubMed id 19915575)1 SimA^n-SA!nchez J....Gasser T. (2009)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
|
External Searches for SFXN2 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SFXN2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SFXN2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SFXN2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for SFXN2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SFXN2 gene: Search GeneIP for patents involving SFXN2
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for SFXN2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| |
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| | | Search Tocris compounds for SFXN2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | SFXN2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFXN2 |
|  |  |  | | | Search ThermoFisher Antibodies for SFXN2 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFXN2 |
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