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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SFXN1 Gene

protein-coding GIFtS: 55
GCID: GC05P174838

Sideroflexin 1

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Sideroflexin 1¹ ²
Tricarboxylate Carrier Protein² ³
TCC² ³
sideroflexin-1²

External Ids:	HGNC: 16085¹	Entrez Gene: 94081²	Ensembl: ENSG00000164466⁷	UniProtKB: Q9H9B4³

Export aliases for SFXN1 gene to outside databases

Previous GC identifers: GC05U990169 GC05P175644 GC05P174840 GC05P174886 GC05P170004

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SFXN1 Gene:

SFXN1 (sideroflexin 1) is a protein-coding gene. Diseases associated with SFXN1 include neonatal anemia, and aceruloplasminemia. GO annotations related to this gene include cation transmembrane transporter activity. An important paralog of this gene is SFXN4.

UniProtKB/Swiss-Prot: SFXN1_HUMAN, Q9H9B4

Function: Might be involved in the transport of a component required for iron utilization into or out of the

mitochondria

Gene Wiki entry for SFXN1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NT_023133.13 NC_018916.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SFXN1 gene promoter:
TBP GCNF E4BP4 HNF-1A AREB6 PPAR-gamma1 GCNF-1 TFIID PPAR-gamma2 GCNF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SFXN1 promoter sequence

Search SABiosciences Chromatin IP Primers for SFXN1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SFXN1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band: 5q35.2 HGNC cytogenetic band: 5q35.3

SFXN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SFXN1 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P174838: view genomic region (about GC identifiers)

Start:	174,904,065 bp from pter	End:	174,956,745 bp from pter
Size:	52,681 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SFXN1_HUMAN, Q9H9B4 (See protein sequence)

Recommended Name: Sideroflexin-1

Size: 322 amino acids; 35619 Da

Subcellular location: Mitochondrion membrane; Multi-pass membrane protein (By similarity)

Sequence caution: Sequence=AAH20517.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=BAB14003.1; Type=Miscellaneous discrepancy; Note=Cloning artifact; Sequence=BAB14318.1; Type=Erroneous

initiation; Note=Translation N-terminally extended;

Secondary accessions: B3KPW3 D3DQN2 Q9HA53

Explore the universe of human proteins at neXtProt for SFXN1: NX_Q9H9B4

Explore proteomics data for SFXN1 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9H9B4

SFXN1 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_073591.2

ENSEMBL proteins:

ENSP00000420961 ENSP00000316905 ENSP00000473710 ENSP00000421982 ENSP00000421467

ENSP00000424270

Human Recombinant Protein Products for SFXN1:

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	Cloud-Clone Corp. Proteins for SFXN1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IDA	--
GO:0005743	mitochondrial inner membrane	IEA	--
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	IEA	--

SFXN1 for ontologies About GeneDecksing

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	Cloud-Clone Corp. ELISAs for SFXN1 Cloud-Clone Corp. CLIAs for SFXN1

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

SFXN: Sideroflexins

1 InterPro protein domain:

IPR004686 Mtc

Graphical View of Domain Structure for InterPro Entry Q9H9B4

ProtoNet protein and cluster: Q9H9B4

1 Blocks protein domain: IPB004686 Tricarboxylate/iron carrier

UniProtKB/Swiss-Prot: SFXN1_HUMAN, Q9H9B4

Similarity: Belongs to the sideroflexin family

SFXN1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SFXN1_HUMAN, Q9H9B4

Function: Might be involved in the transport of a component required for iron utilization into or out of the

mitochondria

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008324	cation transmembrane transporter activity	IEA	--

SFXN1 for ontologies About GeneDecksing

Phenotypes:
1 MGI phenotypic allele

for Sfxn1 (no phenotypes)

SFXN1 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for SFXN1

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SFXN1

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SFXN1

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SFXN1

miRNA Products:		miRTarBase miRNAs that target SFXN1: hsa-mir-1 (MIRT001335)

		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SFXN1
		8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate SFXN1 (see all 30):
		hsa-miR-30c hsa-miR-142-5p hsa-miR-3673 hsa-miR-562 hsa-miR-15a hsa-miR-503 hsa-miR-16-1* hsa-miR-30d

		SwitchGear 3'UTR luciferase reporter plasmid: SFXN1 3' UTR sequence

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SFXN1
		Search LifeMap BioReagents cell lines for SFXN1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFXN1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SFXN1

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/267 Interacting proteins for SFXN1 (Q9H9B4^{1, 2, 3} ENSP00000316905⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 267)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IKBKG	Q9Y6K9²^,³, ENSP00000358622⁴	MINT-48148 I2D: score=2 STRING: ENSP00000358622
TSC22D1	Q15714¹^,³	EBI-355861,EBI-712609 I2D: score=2
PGRMC1	O00264¹^,³, ENSP00000217971⁴	EBI-355861,EBI-1045534 I2D: score=2 STRING: ENSP00000217971
ICT1	Q14197²^,³, ENSP00000301585⁴	MINT-8079030 I2D: score=1 STRING: ENSP00000301585
UBA5	Q9GZZ9³, ENSP00000348565⁴	I2D: score=3 STRING: ENSP00000348565

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006812	cation transport	--	--
GO:0006826	iron ion transport	IEA	--
GO:0030218	erythrocyte differentiation	IEA	--
GO:0055072	iron ion homeostasis	IEA	--
GO:0055085	transmembrane transport	--	--

SFXN1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SFXN1

1 HMDB Compound for SFXN1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Iron	Armco iron (see all 19)	7439-89-6	--

Search CenterWatch for drugs/clinical trials and news about SFXN1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SFXN1 gene:

NM_022754.5

Unigene Cluster for SFXN1:

Sideroflexin 1

Hs.369440 [show with all ESTs]

Unigene Representative Sequence: NM_022754

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000507017 ENST00000321442(uc003mda.2) ENST00000508290 ENST00000507395

ENST00000515791 ENST00000502393 ENST00000507823(uc003mdb.1) ENST00000513725

ENST00000506963 ENST00000502865 ENST00000515736 ENST00000421887

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SFXN1
		8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate SFXN1 (see all 30):
		hsa-miR-30c hsa-miR-142-5p hsa-miR-3673 hsa-miR-562 hsa-miR-15a hsa-miR-503 hsa-miR-16-1* hsa-miR-30d

		SwitchGear 3'UTR luciferase reporter plasmid: SFXN1 3' UTR sequence

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Clone Products:		OriGene clones in human, mouse for SFXN1 (see all 7) OriGene ORF clones in mouse, rat for SFXN1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SFXN1 (NM_022754)
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Additional mRNA sequence:

AK022287.1 AK022938.1 AK025032.1 AK056915.1 BC020517.1 BC063241.1 BX648188.1

14 DOTS entries:

DT.413038 DT.40257647 DT.100047356 DT.91918185 DT.91749122 DT.100792319 DT.100808897 DT.102830359

DT.91643054 DT.120806935 DT.120806967 DT.65287012 DT.91992105 DT.97771092

24/211 AceView cDNA sequences (see all 211):

BE550926 AI014241 BX509399 BM128746 BM928783 BQ216550 CN481191 BU956596

BX369174 AA973546 BC020517 F11510 AW614734 BP363027 AW502257 CN482188

BQ225449 BX951549 BG235896 BX483956 CA865759 BQ421555 CR599132 BE741335

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SFXN1 (see all 7) About this scheme

ExUns:	1	^	2	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12a	·	12b
SP1:											-				-												-						-		-
SP2:					-						-				-												-
SP3:											-				-								-				-						-		-
SP4:											-				-
SP5:											-

ECgene alternative splicing isoforms for SFXN1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SFXN1 expression in normal human tissues (normalized intensities) SFXN1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AAGTGTAGAT

About this image

SFXN1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/3 selected tissues (see all 3) fully expand


Blood (Hematopoietic System) fully expand to see all 2 entries
cd3+ t cells

Liver (Hepatobiliary System)
Periportal Hepatocytes Liver Lobule

Eye (Sensory Organs)
Mature Horizontal Cells Inner Nuclear Layer

See SFXN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SFXN1

SOURCE GeneReport for Unigene cluster: Hs.369440

SABiosciences Expression via Pathway-Focused PCR Array including SFXN1:

Hematopoiesis in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for SFXN1 gene from 8/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sfxn1^{1 , 5}	sideroflexin 1^{1, 5}	84.58(n)¹ 94.72(a)¹		13 (28.40 cM)⁵ 14057¹ NM_027324.5¹ NP_081600.1¹ 54071845⁵
chicken (Gallus gallus)	Aves	SFXN1¹	sideroflexin 1	81.37(n) 90.99(a)		416221 XM_414544.3 XP_414544.2
lizard (Anolis carolinensis)	Reptilia	SFXN1⁶	Uncharacterized protein	81(a)	1 ↔ 1	2(137172283-137205488)
African clawed frog (Xenopus laevis)	Amphibia	xm278-prov²	sideroflexin 1	75(n)		BC044027.1
zebrafish (Danio rerio)	Actinopterygii	sfxn1¹	sideroflexin 1	75.05(n) 84.16(a)		445143 NM_001003537.1 NP_001003537.1
fruit fly (Drosophila melanogaster)	Insecta	CG11739¹	CG11739	55.38(n) 55.38(a)		40552 NM_164347.2 NP_730823.2
worm (Caenorhabditis elegans)	Secernentea	sfxn-1.5¹	Protein SFXN-1.5	58.01(n) 55.13(a)		181353 NM_077548.3 NP_509949.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	FSF1⁶	Putative protein, predicted to be an alpha-isoprop...	37(a)	1 → many	XV(831059-832042)

ENSEMBL Gene Tree for SFXN1 (if available)
TreeFam Gene Tree for SFXN1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SFXN1 gene

SFXN4² SFXN5² SFXN2² SFXN3²

3 SIMAP similar genes for SFXN1 using alignment to 5 protein entries: SFXN1_HUMAN (see all proteins):

SFXN3 SFXN2 SFXN5

SFXN1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs117675680^1,2	C,F	--	174903547(+)	`GGAGCG/AGAGCC`	1	--	us2k¹		1		EA	120
rs114175457^1,2	F	--	174903644(+)	`TGACCA/TTAGAC`	1	--	us2k¹		1		WA	118
rs143923263^1,2		--	174903728(+)	`ACTAAA/TTGTTT`	1	--	us2k¹		0	--	--	--	--
rs267349^1,2	C,F,A,H	--	174903767(-)	`CTATAT/AGACAA`	1	--	us2k¹		29		NS EA NA WA CSA	2669
rs113590298^1,2	C,F	--	174903779(+)	`ATTACT/CGTGGC`	1	--	us2k¹		2		CSA WA	120
rs180741223^1,2		--	174903976(+)	`TTGCTC/TACAAG`	1	--	us2k¹		0	--	--	--	--
rs116264037^1,2	F	--	174904080(+)	`CACCTA/GGGTTG`	1	--	us2k¹		1		WA	118
rs186652676^1,2		--	174904110(+)	`CAGCCA/GACTGC`	1	--	us2k¹		0	--	--	--	--
rs150631307^1,2		--	174904180(+)	`CATACA/GCCACC`	1	--	us2k¹		0	--	--	--	--
rs58498006^1,2	C	--	174904278(+)	`CACTCC/TGGCCT`	1	--	us2k¹		2		WA	120

HapMap Linkage Disequilibrium report for SFXN1 (174904065 - 174956745 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for SFXN1: About this table

Variant ID	Type	Subtype	PubMed ID
nsv469707	CNV	Loss	16826518

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing SFXN1

DNA2.0 Custom Variant and Variant Library Synthesis for SFXN1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

4 diseases for SFXN1: About MalaCards

neonatal anemia aceruloplasminemia sideroblastic anemia anemia

1 disease from the University of Copenhagen DISEASES database for SFXN1:

Aceruloplasminemia

SFXN1 for disorders About GeneDecksing

Genetic Association Database (GAD): SFXN1
Human Genome Epidemiology (HuGE) Navigator: SFXN1 (1 document)

Export disorders for SFXN1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SFXN1 gene, integrated from 9 sources (see all 38):
(articles sorted by number of sources associating them with SFXN1)

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Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)^{1, 4} Hendrickson S.L....O'Brien S.J. (2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. (PubMed id 23464991)¹ Scifo E....Lalowski M. (2013)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
PKCe promotes oncogenic functions of ATF2 in the nucle us while blocking its apoptotic function at mitochondria. (PubMed id 22304920)¹ Lau E....Ronai Z.A. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation. (PubMed id 21081666)¹ Greco T.M....Cristea I.M. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 94081	HGNC: 16085	AceView: SFXN1	Ensembl:ENSG00000164466	euGenes: HUgn94081
ECgene: SFXN1	H-InvDB: SFXN1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SFXN1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SFXN1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SFXN1 gene:
Search GeneIP for patents involving SFXN1

GeneCards and IP:
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