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Aliases for SFTPD Gene

Aliases for SFTPD Gene

  • Surfactant Protein D 2 3
  • Lung Surfactant Protein D 3 4
  • Collectin-7 3 4
  • COLEC7 3 4
  • SFTP4 3 4
  • PSP-D 3 4
  • SP-D 3 4
  • Surfactant, Pulmonary-Associated Protein D 2
  • Surfactant-Associated Protein, Pulmonary 4 3
  • Pulmonary Surfactant Apoprotein 3
  • PSPD 4

External Ids for SFTPD Gene

Previous HGNC Symbols for SFTPD Gene

  • SFTP4

Previous GeneCards Identifiers for SFTPD Gene

  • GC10M080654
  • GC10M080919
  • GC10M081828
  • GC10M081362
  • GC10M081019
  • GC10M081687
  • GC10M075540

Summaries for SFTPD Gene

Entrez Gene Summary for SFTPD Gene

  • The protein encoded by this gene is part of the innate immune response, protecting the lungs against inhaled microorganisms and chemicals. The encoded protein may also be involved in surfactant metabolism. [provided by RefSeq, Jul 2015]

GeneCards Summary for SFTPD Gene

SFTPD (Surfactant Protein D) is a Protein Coding gene. Diseases associated with SFTPD include wilson-mikity syndrome and chest wall lymphoma. Among its related pathways are Infectious disease and Transport to the Golgi and subsequent modification. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is COLEC11.

UniProtKB/Swiss-Prot for SFTPD Gene

  • Contributes to the lungs defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.

Gene Wiki entry for SFTPD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFTPD Gene

Genomics for SFTPD Gene

Regulatory Elements for SFTPD Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SFTPD Gene

Chromosome:
10
Start:
79,937,740 bp from pter
End:
79,982,614 bp from pter
Size:
44,875 bases
Orientation:
Minus strand

Genomic View for SFTPD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SFTPD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFTPD Gene

Proteins for SFTPD Gene

  • Protein details for SFTPD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35247-SFTPD_HUMAN
    Recommended name:
    Pulmonary surfactant-associated protein D
    Protein Accession:
    P35247
    Secondary Accessions:
    • Q5T0M3
    • Q6FH08
    • Q86YK9
    • Q8TCD8
    • Q9UCJ2
    • Q9UCJ3

    Protein attributes for SFTPD Gene

    Size:
    375 amino acids
    Molecular mass:
    37728 Da
    Quaternary structure:
    • Oligomeric complex of 4 set of homotrimers
    Miscellaneous:
    • Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C)

    Three dimensional structures from OCA and Proteopedia for SFTPD Gene

neXtProt entry for SFTPD Gene

Proteomics data for SFTPD Gene at MOPED

Post-translational modifications for SFTPD Gene

  • Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.
  • S-nitrosylation at Cys-35 and Cys-40 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages.
  • The N-terminus is blocked
  • Glycosylation at Asn 90
  • Modification sites at PhosphoSitePlus

Other Protein References for SFTPD Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SFTPD Gene

Domains & Families for SFTPD Gene

Gene Families for SFTPD Gene

Suggested Antigen Peptide Sequences for SFTPD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35247

UniProtKB/Swiss-Prot:

SFTPD_HUMAN :
  • Contains 1 C-type lectin domain.
  • Belongs to the SFTPD family.
Domain:
  • Contains 1 C-type lectin domain.
  • Contains 1 collagen-like domain.
Family:
  • Belongs to the SFTPD family.
genes like me logo Genes that share domains with SFTPD: view

Function for SFTPD Gene

Molecular function for SFTPD Gene

GENATLAS Biochemistry:
surfactant-associated glycoprotein D member of the collectin family,pulmonary,playing an important role in innate immunity by binding to specific carbohydrate structures found at the surface of pathogenic microorganisms
UniProtKB/Swiss-Prot Function:
Contributes to the lungs defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.

Gene Ontology (GO) - Molecular Function for SFTPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12884308
GO:0030246 carbohydrate binding TAS 10485905
genes like me logo Genes that share ontologies with SFTPD: view
genes like me logo Genes that share phenotypes with SFTPD: view

Animal Models for SFTPD Gene

MGI Knock Outs for SFTPD:

Animal Model Products

CRISPR Products

miRNA for SFTPD Gene

miRTarBase miRNAs that target SFTPD

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SFTPD

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SFTPD Gene

Localization for SFTPD Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFTPD Gene

Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SFTPD Gene COMPARTMENTS Subcellular localization image for SFTPD gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5

Gene Ontology (GO) - Cellular Components for SFTPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 9751757
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005581 collagen trimer IEA --
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with SFTPD: view

Pathways & Interactions for SFTPD Gene

genes like me logo Genes that share pathways with SFTPD: view

Pathways by source for SFTPD Gene

1 KEGG pathway for SFTPD Gene
1 GeneGo (Thomson Reuters) pathway for SFTPD Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for SFTPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001817 regulation of cytokine production NAS 9751757
GO:0006898 receptor-mediated endocytosis TAS 10485905
GO:0007585 respiratory gaseous exchange IEA --
GO:0042130 negative regulation of T cell proliferation TAS 10485905
GO:0042742 defense response to bacterium TAS 9751757
genes like me logo Genes that share ontologies with SFTPD: view

No data available for SIGNOR curated interactions for SFTPD Gene

Drugs & Compounds for SFTPD Gene

(20) Drugs for SFTPD Gene - From: NovoSeek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Budesonide Approved Pharma Anti-inflammatory corticosteroid 368
Dexamethasone Approved, Investigational Pharma Agonist 1806
Gefitinib Approved, Investigational Pharma EGFR Inhibitors, Kinase Inhibitors, Epidermal growth factor receptor (EGFR) inhibitors 322
hydroxyproline Approved, Experimental Pharma 0
Nitric Oxide Approved Pharma 540

(24) Additional Compounds for SFTPD Gene - From: NovoSeek

genes like me logo Genes that share compounds with SFTPD: view

Transcripts for SFTPD Gene

mRNA/cDNA for SFTPD Gene

Unigene Clusters for SFTPD Gene

Surfactant protein D:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SFTPD

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SFTPD Gene

No ASD Table

Relevant External Links for SFTPD Gene

GeneLoc Exon Structure for
SFTPD
ECgene alternative splicing isoforms for
SFTPD

Expression for SFTPD Gene

mRNA expression in normal human tissues for SFTPD Gene

mRNA differential expression in normal tissues according to GTEx for SFTPD Gene

This gene is overexpressed in Lung (x40.8).

Protein differential expression in normal tissues from HIPED for SFTPD Gene

This gene is overexpressed in Lavage (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SFTPD Gene



SOURCE GeneReport for Unigene cluster for SFTPD Gene Hs.253495

mRNA Expression by UniProt/SwissProt for SFTPD Gene

P35247-SFTPD_HUMAN
Tissue specificity: Expressed in lung, brain, pancreas and adipose tissue (mainly mature adipocytes).
genes like me logo Genes that share expression patterns with SFTPD: view

Protein tissue co-expression partners for SFTPD Gene

Primer Products

In Situ Assay Products

Orthologs for SFTPD Gene

This gene was present in the common ancestor of chordates.

Orthologs for SFTPD Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SFTPD 35
  • 80.77 (n)
  • 73.95 (a)
CGN1 36
  • 67 (a)
OneToMany
CL43 36
  • 62 (a)
OneToMany
CL46 36
  • 70 (a)
OneToMany
SFTPD 36
  • 74 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SFTPD 35
  • 80.99 (n)
  • 76.86 (a)
SFTPD 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sftpd 35
  • 80.17 (n)
  • 75.21 (a)
Sftpd 16
Sftpd 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SFTPD 35
  • 93.91 (n)
  • 93.04 (a)
rat
(Rattus norvegicus)
Mammalia Sftpd 35
  • 79.06 (n)
  • 75.48 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 53 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SFTPD 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SFTPD 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100135366 35
  • 51.96 (n)
  • 47.89 (a)
zebrafish
(Danio rerio)
Actinopterygii CR847898.1 36
  • 25 (a)
ManyToMany
hbl1 36
  • 35 (a)
ManyToMany
hbl2 36
  • 38 (a)
ManyToMany
hbl3 36
  • 33 (a)
ManyToMany
hbl4 36
  • 37 (a)
ManyToMany
Species with no ortholog for SFTPD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SFTPD Gene

ENSEMBL:
Gene Tree for SFTPD (if available)
TreeFam:
Gene Tree for SFTPD (if available)

Paralogs for SFTPD Gene

Paralogs for SFTPD Gene

genes like me logo Genes that share paralogs with SFTPD: view

Variants for SFTPD Gene

Sequence variations from dbSNP and Humsavar for SFTPD Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs721917 Benign, Benign, - 79,946,568(-) AACAA(C/T)GCCCA missense, reference
rs723191 -- 79,948,164(+) CCAGC(A/G)GCGGC intron-variant
rs723192 -- 79,948,257(+) TGCCC(C/T)GCAGC intron-variant
rs723193 -- 79,948,399(+) GACCC(G/T)GGTTT intron-variant
rs726014 -- 79,948,988(-) ATTCA(A/G)CCTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SFTPD Gene

Variant ID Type Subtype PubMed ID
nsv895801 CNV Gain 21882294
nsv895802 CNV Gain 21882294
nsv467391 CNV Gain 19166990
nsv831922 CNV Loss 17160897
esv2738751 CNV Deletion 23290073

Variation tolerance for SFTPD Gene

Residual Variation Intolerance Score: 67.18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.90; 67.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SFTPD Gene

HapMap Linkage Disequilibrium report
SFTPD
Human Gene Mutation Database (HGMD)
SFTPD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFTPD Gene

Disorders for SFTPD Gene

MalaCards: The human disease database

(32) MalaCards diseases for SFTPD Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
wilson-mikity syndrome
  • pulmonary dysmaturity syndrome
chest wall lymphoma
  • lymphoma of chest wall
tracheal agenesis
  • congenital tracheal agenesis
extrinsic allergic alveolitis
  • hypersensitivity pneumonitis
interstitial lung disease
  • ild
- elite association
Search SFTPD in MalaCards View complete list of genes associated with diseases

Relevant External Links for SFTPD

Genetic Association Database (GAD)
SFTPD
Human Genome Epidemiology (HuGE) Navigator
SFTPD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SFTPD
genes like me logo Genes that share disorders with SFTPD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SFTPD Gene

Publications for SFTPD Gene

  1. Purification, characterization and cDNA cloning of human lung surfactant protein D. (PMID: 1339284) Lu J. … Reid K.B.M. (Biochem. J. 1992) 2 23 67
  2. Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain. (PMID: 1898081) Rust K. … Crouch E. (Arch. Biochem. Biophys. 1991) 2 23 67
  3. Surfactant protein D interacts with alpha2-macroglobulin and increases its innate immune potential. (PMID: 20207732) Craig-Barnes H.A. … Palaniyar N. (J. Biol. Chem. 2010) 23 67
  4. SP-D and regulation of the pulmonary innate immune system in allergic airway changes. (PMID: 20447075) Forbes L.R. … Haczku A. (Clin. Exp. Allergy 2010) 23 67
  5. Insight into the dynamic interaction of different carbohydrates with human surfactant protein D: molecular dynamics simulations. (PMID: 20450150) Zhang J. … Zhang H. (J Phys Chem B 2010) 23 67

Products for SFTPD Gene

Sources for SFTPD Gene

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