Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SFTPD Gene

Aliases for SFTPD Gene

  • Surfactant Protein D 2 3
  • SFTP4 3 4 6
  • Surfactant, Pulmonary-Associated Protein D 2 3
  • Lung Surfactant Protein D 3 4
  • Collectin-7 3 4
  • COLEC7 3 4
  • PSP-D 3 4
  • SP-D 3 4
  • Surfactant-Associated Protein, Pulmonary 4 3
  • Pulmonary Surfactant-Associated Protein D 3
  • Pulmonary Surfactant Apoprotein 3
  • Collectin 7 3
  • PSPD 4

External Ids for SFTPD Gene

Previous Symbols for SFTPD Gene

  • SFTP4

Summaries for SFTPD Gene

GeneCards Summary for SFTPD Gene

SFTPD (Surfactant Protein D) is a Protein Coding gene. Diseases associated with SFTPD include wilson-mikity syndrome and pneumonia. Among its related pathways are FOXA1 transcription factor network and Bacterial infections in CF airways. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is COLEC11.

UniProtKB/Swiss-Prot for SFTPD Gene

  • Contributes to the lungs defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.

Gene Wiki entry for SFTPD Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFTPD Gene

Genomics for SFTPD Gene

Genomic Location for SFTPD Gene

Start:
79,937,740 bp from pter
End:
79,982,614 bp from pter
Size:
44,875 bases
Orientation:
Minus strand

Genomic View for SFTPD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SFTPD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFTPD Gene

Regulatory Elements for SFTPD Gene

Proteins for SFTPD Gene

  • Protein details for SFTPD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35247-SFTPD_HUMAN
    Recommended name:
    Pulmonary surfactant-associated protein D
    Protein Accession:
    P35247
    Secondary Accessions:
    • Q5T0M3
    • Q6FH08
    • Q86YK9
    • Q8TCD8
    • Q9UCJ2
    • Q9UCJ3

    Protein attributes for SFTPD Gene

    Size:
    375 amino acids
    Molecular mass:
    37728 Da
    Quaternary structure:
    • Oligomeric complex of 4 set of homotrimers
    Miscellaneous:
    • Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C)

    Three dimensional structures from OCA and Proteopedia for SFTPD Gene

neXtProt entry for SFTPD Gene

Proteomics data for SFTPD Gene at MOPED

Post-translational modifications for SFTPD Gene

  • Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.
  • S-nitrosylation at Cys-35 and Cys-40 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages.
  • The N-terminus is blocked
  • Glycosylation at Asn90

Other Protein References for SFTPD Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SFTPD Gene

Domains for SFTPD Gene

Gene Families for SFTPD Gene

HGNC:

UniProtKB/Swiss-Prot:

SFTPD_HUMAN
Domain:
  • Contains 1 C-type lectin domain.:
    • P35247
  • Contains 1 collagen-like domain.:
    • P35247
Family:
  • Belongs to the SFTPD family.:
    • P35247
genes like me logo Genes that share domains with SFTPD: view

Function for SFTPD Gene

Molecular function for SFTPD Gene

GENATLAS Biochemistry: surfactant-associated glycoprotein D member of the collectin family,pulmonary,playing an important role in innate immunity by binding to specific carbohydrate structures found at the surface of pathogenic microorganisms
UniProtKB/Swiss-Prot Function: Contributes to the lungs defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.

Gene Ontology (GO) - Molecular Function for SFTPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12884308
GO:0030246 carbohydrate binding TAS 10485905
genes like me logo Genes that share ontologies with SFTPD: view
genes like me logo Genes that share phenotypes with SFTPD: view

Animal Models for SFTPD Gene

MGI Knock Outs for SFTPD:

miRNA for SFTPD Gene

miRTarBase miRNAs that target SFTPD

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SFTPD Gene

Localization for SFTPD Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFTPD Gene

Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SFTPD Gene COMPARTMENTS Subcellular localization image for SFTPD gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SFTPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 9751757
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005581 collagen trimer IEA --
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with SFTPD: view

Pathways for SFTPD Gene

genes like me logo Genes that share pathways with SFTPD: view

Pathways by source for SFTPD Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for SFTPD Gene
1 KEGG pathway for SFTPD Gene

Gene Ontology (GO) - Biological Process for SFTPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001817 regulation of cytokine production NAS 9751757
GO:0006898 receptor-mediated endocytosis TAS 10485905
GO:0007585 respiratory gaseous exchange IEA --
GO:0042130 negative regulation of T cell proliferation TAS 10485905
GO:0042742 defense response to bacterium TAS 9751757
genes like me logo Genes that share ontologies with SFTPD: view

Compounds for SFTPD Gene

(1) Drugbank Compounds for SFTPD Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Beta-D-Glucose
50-99-7 target

(43) Novoseek inferred chemical compound relationships for SFTPD Gene

Compound -log(P) Hits PubMed IDs
mannan 73.4 9
sivelestat 68.7 5
mannose 67 22
sivelestat sodium hydrate 66.7 1
maltose 66.2 19
genes like me logo Genes that share compounds with SFTPD: view

Transcripts for SFTPD Gene

mRNA/cDNA for SFTPD Gene

Unigene Clusters for SFTPD Gene

Surfactant protein D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SFTPD Gene

No ASD Table

Relevant External Links for SFTPD Gene

GeneLoc Exon Structure for
SFTPD
ECgene alternative splicing isoforms for
SFTPD

Expression for SFTPD Gene

mRNA expression in normal human tissues for SFTPD Gene

mRNA differential expression in normal tissues according to GTEx for SFTPD Gene

This gene is overexpressed in Lung (40.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SFTPD Gene

SOURCE GeneReport for Unigene cluster for SFTPD Gene Hs.253495

mRNA Expression by UniProt/SwissProt for SFTPD Gene

P35247-SFTPD_HUMAN
Tissue specificity: Expressed in lung, brain, pancreas and adipose tissue (mainly mature adipocytes).
genes like me logo Genes that share expressions with SFTPD: view

Orthologs for SFTPD Gene

This gene was present in the common ancestor of chordates.

Orthologs for SFTPD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SFTPD 36
  • 93.91 (n)
  • 93.04 (a)
cow
(Bos Taurus)
Mammalia CGN1 37
  • 67 (a)
OneToMany
CL43 37
  • 62 (a)
OneToMany
CL46 37
  • 70 (a)
OneToMany
SFTPD 36
  • 80.77 (n)
  • 73.95 (a)
SFTPD 37
  • 74 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SFTPD 36
  • 80.99 (n)
  • 76.86 (a)
SFTPD 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sftpd 36
  • 80.17 (n)
  • 75.21 (a)
Sftpd 16
Sftpd 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 53 (a)
OneToMany
-- 37
  • 63 (a)
OneToMany
-- 37
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SFTPD 37
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sftpd 36
  • 79.06 (n)
  • 75.48 (a)
lizard
(Anolis carolinensis)
Reptilia SFTPD 37
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100135366 36
  • 51.96 (n)
  • 47.89 (a)
zebrafish
(Danio rerio)
Actinopterygii CR847898.1 37
  • 25 (a)
ManyToMany
hbl1 37
  • 35 (a)
ManyToMany
hbl2 37
  • 38 (a)
ManyToMany
hbl3 37
  • 33 (a)
ManyToMany
hbl4 37
  • 37 (a)
ManyToMany
Species with no ortholog for SFTPD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SFTPD Gene

ENSEMBL:
Gene Tree for SFTPD (if available)
TreeFam:
Gene Tree for SFTPD (if available)

Paralogs for SFTPD Gene

Paralogs for SFTPD Gene

genes like me logo Genes that share paralogs with SFTPD: view

Variants for SFTPD Gene

Sequence variations from dbSNP and Humsavar for SFTPD Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs721917 Benign, - 79,946,568(-) AACAA(C/T)GCCCA missense, reference
rs723191 -- 79,948,164(+) CCAGC(A/G)GCGGC intron-variant
rs723192 -- 79,948,257(+) TGCCC(C/T)GCAGC intron-variant
rs723193 -- 79,948,399(+) GACCC(G/T)GGTTT intron-variant
rs726014 -- 79,948,988(-) ATTCA(A/G)CCTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SFTPD Gene

Variant ID Type Subtype PubMed ID
nsv895801 CNV Gain 21882294
nsv895802 CNV Gain 21882294
nsv467391 CNV Gain 19166990
nsv831922 CNV Loss 17160897
esv2738751 CNV Deletion 23290073

Relevant External Links for SFTPD Gene

HapMap Linkage Disequilibrium report
SFTPD
Human Gene Mutation Database (HGMD)
SFTPD

Disorders for SFTPD Gene

(70) Novoseek inferred disease relationships for SFTPD Gene

Disease -log(P) Hits PubMed IDs
pulmonary alveolar proteinosis 80.9 15
bronchoalveolar lavage fluid 74.2 28
lung diseases interstitial 73.4 17
respiratory distress syndrome 70.8 9
pneumonia interstitial 70.6 22

Relevant External Links for SFTPD

Genetic Association Database (GAD)
SFTPD
Human Genome Epidemiology (HuGE) Navigator
SFTPD
genes like me logo Genes that share disorders with SFTPD: view

No data available for UniProtKB/Swiss-Prot for SFTPD Gene

Publications for SFTPD Gene

  1. Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain. (PMID: 1898081) Rust K. … Crouch E. (Arch. Biochem. Biophys. 1991) 2 3 4 23
  2. Purification, characterization and cDNA cloning of human lung surfactant protein D. (PMID: 1339284) Lu J. … Reid K.B.M. (Biochem. J. 1992) 2 3 4 23
  3. Accumulation of surfactant protein D in human pulmonary alveolar proteinosis. (PMID: 8424457) Crouch E. … Chang D. (Am. J. Pathol. 1993) 3 4 23
  4. Genomic organization of human surfactant protein D (SP-D). SP-D is encoded on chromosome 10q22.2-23.1. (PMID: 8428971) Crouch E. … Grosso L. (J. Biol. Chem. 1993) 3 4 23
  5. Polymorphisms in the human surfactant protein-D (SFTPD) gene: strong evidence that serum levels of surfactant protein-D (SP-D) are genetically influenced. (PMID: 15700120) Heidinger K. … Bein G. (Immunogenetics 2005) 3 23 49

Products for SFTPD Gene

Sources for SFTPD Gene

Back to Top

Content