Aliases for SFTPD Gene
External Ids for SFTPD Gene
Previous HGNC Symbols for SFTPD Gene
Previous GeneCards Identifiers for SFTPD Gene
The protein encoded by this gene is part of the innate immune response, protecting the lungs against inhaled microorganisms and chemicals. The encoded protein may also be involved in surfactant metabolism. [provided by RefSeq, Jul 2015]
GeneCards Summary for SFTPD Gene
SFTPD (Surfactant Protein D) is a Protein Coding gene. Diseases associated with SFTPD include Extrinsic Allergic Alveolitis and Wilson-Mikity Syndrome. Among its related pathways are Diseases of metabolism and Phagosome. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is COLEC11.
UniProtKB/Swiss-Prot for SFTPD Gene
Contributes to the lungs defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.