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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SFTPD Gene

protein-coding GIFtS: 63
GCID: GC10M081687

surfactant protein D

(Previous names: surfactant, pulmonary-associated protein D )
(Previous symbol: SFTP4)

Explore 85 diseases affiliated with
SFTPD via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Surfactant Protein D¹ ²		Collectin 7²
SFTP4¹ ² ³ ⁵		Collectin-7³
COLEC7¹ ² ³		Pulmonary Surfactant Apoprotein²
SP-D¹ ² ³		Pulmonary Surfactant-Associated Protein D²
Surfactant, Pulmonary-Associated Protein D¹ ²		Surfactant-Associated Protein, Pulmonary 4²
Lung Surfactant Protein D² ³		Collectin-7³
PSP-D² ³		PSPD³

External Ids:	HGNC: 10803¹	Entrez Gene: 6441²	Ensembl: ENSG00000133661⁷	OMIM: 178635⁵	UniProtKB: P35247³

Export aliases for SFTPD gene to outside databases

Previous GC identifers: GC10M080654 GC10M080919 GC10M081828 GC10M081362 GC10M081019 GC10M075540

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SFTPD_HUMAN, P35247

Function: Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular

reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other

alpha-glucosyl moieties

Gene Wiki entry for SFTPD (Surfactant protein D)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SFTPD gene promoter:
c-Fos AP-1 JunB FosB Fra-1 Arnt JunD IRF-7A c-Jun Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SFTPD promoter sequence

Search SABiosciences Chromatin IP Primers for SFTPD

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SFTPD

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.2-q23.1 Ensembl cytogenetic band: 10q22.3 HGNC cytogenetic band: 10q22.2-q23.1

SFTPD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SFTPD gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M081687: view genomic region (about GC identifiers)

Start:	81,697,496 bp from pter	End:	81,742,370 bp from pter
Size:	44,875 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SFTPD_HUMAN, P35247 (See protein sequence)

Recommended Name: Pulmonary surfactant-associated protein D precursor

Size: 375 amino acids; 37728 Da

Subunit: Oligomeric complex of 4 set of homotrimers

Subcellular location: Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film

Miscellaneous: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins:

2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C)

6/22 PDB 3D structures from and Proteopedia for SFTPD (see all 22):

1B08 (3D)

1M7L (3D)

1PW9 (3D)

1PWB (3D)

2GGU (3D)

2GGX (3D)

Secondary accessions: Q5T0M3 Q6FH08 Q86YK9 Q8TCD8 Q9UCJ2 Q9UCJ3

Explore the universe of human proteins at neXtProt for SFTPD: NX_P35247

Post-translational modifications:

The N-terminus is blocked¹

Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the

requirement for 4-hydroxylation in vertebrates (By similarity)¹

View neXtProt modification sites for NX_P35247

SFTPD Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003010.4

ENSEMBL proteins:

ENSP00000361366 ENSP00000394325

Reactome Protein details: P35247
Human Recombinant Protein Products:

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	Sino Biological Recombinant Protein for SFTPD
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	Browse Proteins at Uscn

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005581	collagen	IEA	--
GO:0005615	extracellular space	IEA	--
GO:0005764	lysosome	TAS	10485905
GO:0030139	endocytic vesicle	TAS	10485905

SFTPD for ontologies About GeneDecksing

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SFTPD for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR015097 Surfac_D-trimer

IPR016187 C-type_lectin_fold

IPR018378 C-type_lectin_CS

IPR016186 C-type_lectin-like

IPR001304 C-type_lectin

Graphical View of Domain Structure for InterPro Entry P35247

ProtoNet protein and cluster: P35247

2 Blocks protein families:

IPB008160 Collagen triple helix repeat

IPB008161 Collagen helix repeat

UniProtKB/Swiss-Prot: SFTPD_HUMAN, P35247

Similarity: Belongs to the SFTPD family

Similarity: Contains 1 C-type lectin domain

Similarity: Contains 1 collagen-like domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SFTPD_HUMAN, P35247

Function: Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular

reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other

alpha-glucosyl moieties

Genatlas biochemistry entry for SFTPD:

surfactant-associated glycoprotein D member of the collectin family,pulmonary,playing an important role in innate

immunity by binding to specific carbohydrate structures found at the surface of pathogenic microorganisms

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		Browse SwitchGear 3'UTR luciferase reporter plasmids

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SFTPD (see all 7) OriGene shRNA RFP: SFTPD OriGene siRNA: SFTPD
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for SFTPD

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFTPD

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	12884308
GO:0030246	carbohydrate binding	TAS	10485905
GO:0051635	bacterial cell surface binding	TAS	9751757

SFTPD for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for SFTPD: Sftpd^tm2Haw Sftpd^tm1Haw Sftpd^tm1Jhf
     6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Sftpd):

growth/size	hematopoietic system	homeostasis/metabolism	immune system	mortality/aging
respiratory system

SFTPD for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Selected targets of C/EBPbeta

Selected targets of C/EBPbeta

1.00

Selected targets of C/EBPalpha

Selected targets of C/EBPalpha

1.00

FOXA1 transcription factor network

FOXA1 transcription factor network

1.00

Regulation of retinoblastoma protein

Regulation of retinoblastoma protein

1.00

Phagosome

Phagosome

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for SFTPD

	Selected targets of C/EBPbeta
	Selected targets of C/EBPalpha

1 GeneGo (Thomson Reuters) Pathway for SFTPD

Bacterial infections in CF airways

2 BioSystems Pathways for SFTPD

	Regulation of retinoblastoma protein
	FOXA1 transcription factor network

2 Reactome Pathways for SFTPD

	Signal regulatory protein (SIRP) family interactions
	Cell-Cell communication

1 Kegg Pathway (Kegg details for SFTPD):

Phagosome

SFTPD for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SFTPD

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/11 Interacting proteins for SFTPD (P35247³ ENSP00000361366⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DCN	P07585³, ENSP00000052754⁴	I2D: score=2 STRING: ENSP00000052754
DMBT1	Q9UGM3³, ENSP00000357905⁴	I2D: score=2 STRING: ENSP00000357905
SFTPA1	Q8IWL2³, ENSP00000361382⁴	I2D: score=1 STRING: ENSP00000361382
MFAP4	P55083³, ENSP00000299610⁴	I2D: score=1 STRING: ENSP00000299610
LY96	Q9Y6Y9³	I2D: score=1

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001817	regulation of cytokine production	NAS	9751757
GO:0006898	receptor-mediated endocytosis	TAS	10485905
GO:0007585	respiratory gaseous exchange	IEA	--
GO:0042130	negative regulation of T cell proliferation	TAS	10485905
GO:0043129	surfactant homeostasis	IMP	9751757

SFTPD for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SFTPD for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SFTPD

1 DrugBank Compound for SFTPD About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Beta-D-Glucose	--	50-99-7	target	--	17139284 17016423

10/43 Novoseek chemical compound relationships for SFTPD gene (see all 43) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mannan	73.4	11	10224141 (1), 11045608 (1), 12816736 (1), 9153228 (1) (see all 9)
sivelestat	68.7	9	15500109 (2), 18992355 (1), 17974096 (1), 17644940 (1)
mannose	67	31	17915943 (2), 17567900 (2), 15187139 (2), 19249874 (2) (see all 18)
sivelestat sodium hydrate	66.7	1	17313021 (1)
maltose	66.2	23	17915943 (3), 9153228 (2), 8918587 (1), 9700129 (1) (see all 16)
phospholipid	40.4	10	10666121 (3), 9870921 (1), 10456901 (1), 9813383 (1) (see all 6)
allergens	40	36	9367408 (5), 17202930 (4), 12706535 (4), 15905537 (3) (see all 11)
hydroxylysine	38.9	1	1339284 (1)
phosphatidylcholine	34.5	2	16889547 (1), 10666121 (1)
phosphatidylinositol	33.5	31	1400434 (6), 1457414 (5), 17417879 (3), 16834340 (2) (see all 9)

Search CenterWatch for drugs/clinical trials and news about SFTPD

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SFTPD gene:

NM_003019.4

Unigene Cluster for SFTPD:

Surfactant protein D

Hs.253495 [show with all ESTs]

Unigene Representative Sequence: BC022318

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000372292(uc001kbh.3) ENST00000444384

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SFTPD
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Additional cDNA sequence:

BC022318.1 CR541948.1

1 DOTS entry:

DT.91644675

24/43 AceView cDNA sequences (see all 43):

BX282004 BM972342 BM985387 AI924488 AI732255 BI821373 BI823937 BG482911

BM994163 BM985241 BI820265 X65018 BI822450 BI819407 BQ030140 BF446634

BQ029770 NM_003019 BI820618 BE465060 BI770406 BC022318 BM970199 CR541948

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SFTPD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGCCAATAT

About this image

SFTPD expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Alveoli

Alveolar Epithelial Type 2 Cells

Selective marker (cell-identifying gene)

Lung

Pancreas

Dorsal Pancreatic Bud

Immature Beta Progenitor Cells

Pancreas

Ventral Pancreatic Bud

Immature Beta Progenitor Cells

Pancreas

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Type II pneumocytes (airway epithelial cells) (Derivation of lung s...)

Alveolar type II cells (Derivation of mature...)

Lung

See SFTPD Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SFTPD

SOURCE GeneReport for Unigene cluster: Hs.253495

SABiosciences Expression via Pathway-Focused PCR Arrays including SFTPD (see all 6):

Cell Lineage Identification in human mouse rat

Terminal Differentiation Markers in human mouse rat

Th1/Th2 Response in human mouse rat

Oxidative Stress in human mouse rat

Antifungal Response in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFTPD

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SFTPD gene from 3/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sftpd^{1 , 5}	surfactant associated protein D^{1, 5}	79.59(n)¹ 74.87(a)¹		14 (22.36 cM)⁵ 20390¹ NM_009160.2¹ NP_033186.1¹ 41172212⁵
lizard (Anolis carolinensis)	Reptilia	SFTPD⁶	--	50(a)	1 ↔ 1	GL343233.1(1470468-1495994)
zebrafish (Danio rerio)	Actinopterygii	hbl1⁶ hbl2⁶ (see all 5)	hexose-binding lectin 2 (see all 5)	34(a) 34(a) (see all 5)	many ↔ many many ↔ many (see all 5)	2(37633260-37635376) 2(37631017-37632321)

ENSEMBL Gene Tree for SFTPD (if available)
TreeFam Gene Tree for SFTPD (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SFTPD gene

SFTPA1² COLEC11² COLEC12² MBL2² COLEC10² SCARA3² SFTPA2²

18/29 SIMAP similar genes for SFTPD using alignment to 3 protein entries: SFTPD_HUMAN (see all proteins) (see all similar genes):

MBL2 COL16A1 COL17A1 MARCO COL21A1 COL3A1

COL11A2 COL5A3 SFTPA2 COL10A1 COL22A1 COL5A1

COL5A2 COL1A1 COL11A1 COL7A1 DKFZp686H17246 SFTPA1

SFTPD for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs144155092^1,2		--	81697083(+)	`TAGCCA/GGGCGT`	1	--	ds500¹		0	--	--	--	--
rs2758547^1,2	C,F,	--	81697124(-)	`CTCTGC/TCTCCC`	1	--	ds500¹		14		NS NA WA CSA EA	469
rs10583219^1,2	C,F	--	81697164(+)	`ACTCC-/GATATTGG`	1	--	ds500¹		3		NS NA	96
rs140809567^1,2	C,	--	81697164(+)	`ACTCC-/GATATTGG`	1	--	ds500¹		0	--	--	--	--
rs17886602^1,2	C,F,	--	81697177(-)	`TCACTC/GTGTCA`	1	--	ds500¹		4		NS WA NA	308
rs138300773^1,2	C,	--	81697193(+)	`GTCTC-/AAAACA`	1	--	ds500¹		0	--	--	--	--
rs6583888^1,2	C,F,A,,	--	81697197(+)	`TCAAAA/CAAAAA`	1	--	ds500¹		5		NS WA NA	98
rs2819099^1,2	C,F,A,	--	81697273(-)	`CCTGCG/AGATCT`	1	--	ds500¹		18		NA NS WA CSA EA	612
rs183746527^1,2		--	81697365(+)	`CTTTTA/TTCCCT`	1	--	ds500¹		0	--	--	--	--
rs17878664^1,2	C,F,	--	81697468(-)	`CAAAAG/CTTACA`	1	--	ds500¹		4		NS WA	212

HapMap Linkage Disequilibrium report for SFTPD (81697496 - 81742370 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SFTPD: --
Human Gene Mutation Database (HGMD): SFTPD

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SFTPD for disorders           About GeneDecksing

OMIM gene information: 178635    OMIM disorders: --

20/85 diseases for SFTPD (see all 85):    About MalaCards

wilson-mikity syndrome mushroom workers' lung pulmonary alveolar proteinosis extrinsic allergic alveolitis

lysinuric protein intolerance allergic bronchopulmonary aspergillosis patent ductus arteriosus connective tissue disease

non-small cell lung carcinoma aspergillosis eosinophilic pneumonia severe acute respiratory syndrome

invasive aspergillosis idiopathic interstitial pneumonia pulmonary eosinophilia pulmonary emphysema

avian influenza chronic obstructive pulmonary disease bronchiolitis obliterans respiratory failure

6 diseases from the University of Copenhagen DISEASES database for SFTPD:

Pneumonia Pulmonary alveolar proteinosis Interstitial lung disease Chronic obstructive pulmonary disease

Influenza Respiratory failure

10/70 Novoseek disease relationships for SFTPD gene (see all 70) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pulmonary alveolar proteinosis	80.9	21	8424457 (2), 19046553 (2), 8046250 (2), 11355171 (1) (see all 12)
bronchoalveolar lavage fluid	74.2	40	19046553 (2), 8918587 (1), 10497393 (1), 15274124 (1) (see all 27)
lung diseases interstitial	73.4	25	11818324 (2), 12421999 (2), 19286849 (2), 14522914 (1) (see all 14)
respiratory distress syndrome	70.8	10	14522914 (1), 16188791 (1), 19348329 (1), 16472150 (1) (see all 9)
pneumonia interstitial	70.6	36	12692985 (3), 10846395 (2), 17874049 (2), 11475580 (2) (see all 17)
fibrosis idiopathic pulmonary	68.8	14	11896896 (1), 19255294 (1), 11321887 (1), 16798048 (1) (see all 10)
lung diseases	68.5	61	10897675 (4), 16684127 (4), 16517507 (3), 16472150 (2) (see all 32)
pneumonitis hypersensitivity	63	5	11083713 (1), 9844346 (1), 16319337 (1), 17874049 (1)
acute respiratory distress	62.7	7	14522914 (1), 16472150 (1), 15244040 (1), 10452960 (1) (see all 6)
acute eosinophilic pneumonia	61.9	2	15357266 (1), 16157978 (1)

Genetic Association Database (GAD): SFTPD
Human Genome Epidemiology (HuGE) Navigator: SFTPD (39 documents)

Export disorders for SFTPD gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SFTPD gene, integrated from 9 sources (see all 497):
(articles sorted by number of sources associating them with SFTPD)

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world of online information

Purification, characterization and cDNA cloning of human lung surfactant protein D. (PubMed id 1339284)^{1, 2, 3, 9} Lu J.... Reid K.B.M. (1992)
Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain. (PubMed id 1898081)^{1, 2, 3, 9} Rust K.... Crouch E. (1991)
Polymorphisms in the human surfactant protein-D (SFTPD) gene: strong evidence that serum levels of surfactant protein-D (SP-D) are genetically influenced. (PubMed id 15700120)^{1, 4, 9} Heidinger K....Bein G. (2005)
A common polymorphism in the SFTPD gene influences assembly, function, and concentration of surfactant protein D. (PubMed id 15661913)^{1, 4, 9} Leth-Larsen R....Holmskov U. (2005)
Accumulation of surfactant protein D in human pulmonary alveolar proteinosis. (PubMed id 8424457)^{1, 2, 9} Crouch E.... Chang D. (1993)
Genomic organization of human surfactant protein D (SP-D). SP-D is encoded on chromosome 10q22.2-23.1. (PubMed id 8428971)^{1, 2, 9} Crouch E.... Grosso L. (1993)
Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis. (PubMed id 13680361)^{1, 4, 9} Selman M.... Floros J. (2003)
Data mining and multiparameter analysis of lung surfactant protein genes in bronchopulmonary dysplasia. (PubMed id 15102713)^{1, 4} Rova M....Hallman M. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{1, 2} Deloukas P.... Rogers J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6441	HGNC: 10803	AceView: SFTPD	Ensembl:ENSG00000133661	euGenes: HUgn6441
ECgene: SFTPD	Kegg: 6441	H-InvDB: SFTPD

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SFTPD	Pharmacogenomics, SNPs, Pathways
SeattleSNPs	http://pga.gs.washington.edu/data/sftpd/
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_228

Intellectual Property for SFTPD gene
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Patent Information for SFTPD gene:
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surfactant protein D

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