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Aliases for SFTPB Gene

Aliases for SFTPB Gene

  • Surfactant Protein B 2 3
  • Pulmonary Surfactant-Associated Proteolipid SPL(Phe) 3 4
  • 18 KDa Pulmonary-Surfactant Protein 3 4
  • 6 KDa Protein 3 4
  • SFTB3 3 6
  • SFTP3 3 4
  • SMDP1 3 6
  • SP-B 3 4
  • Surfactant, Pulmonary-Associated Protein B 2
  • Pulmonary Surfactant-Associated Protein B 3
  • PSP-B 3

External Ids for SFTPB Gene

Previous HGNC Symbols for SFTPB Gene

  • SFTP3

Previous GeneCards Identifiers for SFTPB Gene

  • GC02M085783
  • GC02M086180
  • GC02M085842
  • GC02M085860
  • GC02M085858
  • GC02M085796
  • GC02M085738
  • GC02M085884
  • GC02M085781

Summaries for SFTPB Gene

Entrez Gene Summary for SFTPB Gene

  • This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, Feb 2010]

GeneCards Summary for SFTPB Gene

SFTPB (Surfactant Protein B) is a Protein Coding gene. Diseases associated with SFTPB include surfactant metabolism dysfunction, pulmonary, 1 and congenital pulmonary alveolar proteinosis. An important paralog of this gene is PSAP.

UniProtKB/Swiss-Prot for SFTPB Gene

  • Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter

Gene Wiki entry for SFTPB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFTPB Gene

Genomics for SFTPB Gene

Regulatory Elements for SFTPB Gene

Transcription factor binding sites by QIAGEN in the SFTPB gene promoter:

Genomic Location for SFTPB Gene

85,657,314 bp from pter
85,668,741 bp from pter
11,428 bases
Minus strand

Genomic View for SFTPB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SFTPB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFTPB Gene

Proteins for SFTPB Gene

  • Protein details for SFTPB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pulmonary surfactant-associated protein B
    Protein Accession:
    Secondary Accessions:
    • Q96R04

    Protein attributes for SFTPB Gene

    381 amino acids
    Molecular mass:
    42117 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.
    • Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C)
    • Sequence=AAA88099.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SFTPB Gene

neXtProt entry for SFTPB Gene

Proteomics data for SFTPB Gene at MOPED

Post-translational modifications for SFTPB Gene

  • Glycosylation at Asn129 and Asn311

Other Protein References for SFTPB Gene

Antibody Products

No data available for DME Specific Peptides for SFTPB Gene

Domains for SFTPB Gene

Protein Domains for SFTPB Gene

Suggested Antigen Peptide Sequences for SFTPB Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 saposin A-type domain.
  • Contains 1 saposin A-type domain.
  • Contains 3 saposin B-type domains.
genes like me logo Genes that share domains with SFTPB: view

No data available for Gene Families for SFTPB Gene

Function for SFTPB Gene

Molecular function for SFTPB Gene

GENATLAS Biochemistry:
surfactant-associated glycoprotein b,pulmonary 3 (18kDa),expressed in the alveolar and non ciliated bronchiolar epithelial cells
UniProtKB/Swiss-Prot Function:
Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter
genes like me logo Genes that share phenotypes with SFTPB: view

Animal Models for SFTPB Gene

MGI Knock Outs for SFTPB:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targets and HOMER Transcription for SFTPB Gene

Localization for SFTPB Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFTPB Gene

Secreted, extracellular space, surface film.

Subcellular locations from

Jensen Localization Image for SFTPB Gene COMPARTMENTS Subcellular localization image for SFTPB gene
Compartment Confidence
extracellular 5
cytoskeleton 2
lysosome 2
nucleus 2
vacuole 2
endoplasmic reticulum 1
endosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SFTPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm --
GO:0005764 lysosome IEA --
genes like me logo Genes that share ontologies with SFTPB: view

Pathways for SFTPB Gene

SuperPathways for SFTPB Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for SFTPB Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: P07988-PSPB_HUMAN ENSP00000377409 for SFTPB Gene via I2D STRING

Gene Ontology (GO) - Biological Process for SFTPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process --
GO:0006665 sphingolipid metabolic process IEA --
GO:0007585 respiratory gaseous exchange IEA --
GO:0009887 organ morphogenesis TAS 10378403
genes like me logo Genes that share ontologies with SFTPB: view

No data available for Pathways by source for SFTPB Gene

Drugs for SFTPB Gene

(72) Novoseek inferred chemical compound relationships for SFTPB Gene

Compound -log(P) Hits PubMed IDs
sinapultide 87.5 5
dppg 86.1 21
lucinactant 84.3 7
dppc 83.4 73
survanta 81.6 7
genes like me logo Genes that share compounds with SFTPB: view

Transcripts for SFTPB Gene

Unigene Clusters for SFTPB Gene

Surfactant protein B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SFTPB Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: -
SP5: -

Relevant External Links for SFTPB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SFTPB Gene

mRNA expression in normal human tissues for SFTPB Gene

mRNA differential expression in normal tissues according to GTEx for SFTPB Gene

This gene is overexpressed in Lung (51.2).

Protein differential expression in normal tissues for SFTPB Gene

This gene is overexpressed in Lung (53.3), Lavage (8.3), and Heart (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SFTPB Gene

SOURCE GeneReport for Unigene cluster for SFTPB Gene Hs.512690

genes like me logo Genes that share expressions with SFTPB: view

Expression partners for SFTPB Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SFTPB Gene

Orthologs for SFTPB Gene

This gene was present in the common ancestor of animals.

Orthologs for SFTPB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SFTPB 35
  • 82.67 (n)
  • 74.72 (a)
  • 70 (a)
(Canis familiaris)
Mammalia SFTPB 35
  • 80.38 (n)
  • 71.77 (a)
  • 64 (a)
(Mus musculus)
Mammalia Sftpb 35
  • 78.58 (n)
  • 71.17 (a)
Sftpb 16
Sftpb 36
  • 67 (a)
(Pan troglodytes)
Mammalia SFTPB 35
  • 98.25 (n)
  • 97.37 (a)
(Rattus norvegicus)
Mammalia Sftpb 35
  • 79.12 (n)
  • 71.35 (a)
(Monodelphis domestica)
Mammalia SFTPB 36
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia SFTPB 36
  • 43 (a)
(Anolis carolinensis)
Reptilia SFTPB 36
  • 32 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sftpb 35
  • 52.18 (n)
  • 38.02 (a)
(Danio rerio)
Actinopterygii sftpba 36
  • 14 (a)
sftpbb 36
  • 14 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sap-r 36
  • 5 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 9 (a)
Species with no ortholog for SFTPB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SFTPB Gene

Gene Tree for SFTPB (if available)
Gene Tree for SFTPB (if available)

Paralogs for SFTPB Gene

Paralogs for SFTPB Gene

genes like me logo Genes that share paralogs with SFTPB: view

Variants for SFTPB Gene

Sequence variations from dbSNP and Humsavar for SFTPB Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs7316 -- 85,658,890(-) CACCA(A/G)TGCTA utr-variant-3-prime, intron-variant
rs9752 -- 85,659,544(-) CTCGG(C/G)AGTCA utr-variant-3-prime, intron-variant
rs10625 -- 85,657,910(+) GGGTG(A/G)GTGGG utr-variant-3-prime, downstream-variant-500B
rs762547 -- 85,664,763(-) CAGAT(A/T)GGGTT intron-variant
rs762548 -- 85,663,630(-) ATGCC(C/T)GCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SFTPB Gene

Variant ID Type Subtype PubMed ID
dgv4202n71 CNV Loss 21882294
nsv874464 CNV Loss 21882294
esv2657560 CNV Deletion 23128226

Relevant External Links for SFTPB Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFTPB Gene

Disorders for SFTPB Gene

(1) OMIM Diseases for SFTPB Gene (178640)


  • Pulmonary surfactant metabolism dysfunction 1 (SMDP1) [MIM:265120]: A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. {ECO:0000269 PubMed:7491219}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Respiratory distress syndrome in premature infants (RDS) [MIM:267450]: A lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called hyaline membranes. {ECO:0000269 PubMed:11063734}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry. A variation Ile to Thr at position 131 influences the association between specific alleles of SFTPA1 and respiratory distress syndrome in premature infants.

(57) Novoseek inferred disease relationships for SFTPB Gene

Disease -log(P) Hits PubMed IDs
respiratory distress syndrome 83.1 40
pulmonary alveolar proteinosis 81.5 6
respiratory failure 72.9 37
lung diseases 70.7 32
hyaline membrane disease 68.9 1

Relevant External Links for SFTPB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SFTPB: view

No data available for Genatlas for SFTPB Gene

Publications for SFTPB Gene

  1. Surfactant proteins A and B as interactive genetic determinants of neonatal respiratory distress syndrome. (PMID: 11063734) Haataja R. … Hallman M. (Hum. Mol. Genet. 2000) 3 4 23 48
  2. Polymorphisms of human SP-A, SP-B, and SP-D genes: association of SP- B Thr131Ile with ARDS. (PMID: 11076040) Lin Z. … Floros J. (Clin. Genet. 2000) 3 4 23 48
  3. Surfactant protein B polymorphism and respiratory distress syndrome in premature twins. (PMID: 12483294) Marttila R. … Hallman M. (Hum. Genet. 2003) 3 23 48
  4. Family-based association tests suggest linkage between surfactant protein B (SP-B) (and flanking region) and respiratory distress syndrome (RDS): SP-B haplotypes and alleles from SP-B-linked loci are risk factors for RDS. (PMID: 16549540) Floros J. … Pavlovic J. (Pediatr. Res. 2006) 3 23 48
  5. Comparison of surfactant protein B polymorphisms of healthy term newborns with preterm newborns having respiratory distress syndrome. (PMID: 17581675) Lyra P.P. … Diniz E.M. (Braz. J. Med. Biol. Res. 2007) 3 23 48

Products for SFTPB Gene

Sources for SFTPB Gene

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