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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SFTPB Gene

protein-coding GIFtS: 54
GCID: GC02M085884

surfactant protein B

(Previous names: surfactant, pulmonary-associated protein B )
(Previous symbol: SFTP3)

Explore 48 diseases affiliated with
SFTPB via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Surfactant Protein B¹ ²		SFTB3² ⁵
SFTP3¹ ² ³		SMDP1² ⁵
SP-B¹ ² ³		Surfactant, Pulmonary-Associated Protein B¹
Pulmonary Surfactant-Associated Proteolipid SPL(Phe)² ³		PSP-B²
18 KDa Pulmonary-Surfactant Protein² ³		Pulmonary Surfactant-Associated Protein B²
6 KDa Protein² ³

External Ids:	HGNC: 10801¹	Entrez Gene: 6439²	Ensembl: ENSG00000168878⁷	OMIM: 178640⁵	UniProtKB: P07988³

Export aliases for SFTPB gene to outside databases

Previous GC identifers: GC02M085783 GC02M086180 GC02M085842 GC02M085860 GC02M085858 GC02M085796 GC02M085738 GC02M085781

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SFTPB:

This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for

lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of

90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is

secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface

tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant

monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism

dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are

associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding

the same protein have been identified.(provided by RefSeq, Feb 2010)

UniProtKB/Swiss-Prot: PSPB_HUMAN, P07988

Function: Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the

air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70

millinewtons per meter

Gene Wiki entry for SFTPB (Pulmonary surfactant-associated protein B)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SFTPB gene promoter:
Sp1 STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SFTPB promoter sequence

Search SABiosciences Chromatin IP Primers for SFTPB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SFTPB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12-p11.2 Ensembl cytogenetic band: 2p11.2 HGNC cytogenetic band: 2p12-p11.2

SFTPB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SFTPB gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M085884: view genomic region (about GC identifiers)

Start:	85,884,437 bp from pter	End:	85,895,864 bp from pter
Size:	11,428 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PSPB_HUMAN, P07988 (See protein sequence)

Recommended Name: Pulmonary surfactant-associated protein B precursor

Size: 381 amino acids; 42117 Da

Subunit: Homodimer; disulfide-linked

Subcellular location: Secreted, extracellular space, surface film

Miscellaneous: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins:

2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C)

Sequence caution: Sequence=AAA88099.1; Type=Erroneous initiation;

6/7 PDB 3D structures from and Proteopedia for SFTPB (see all 7):

1DFW (3D)

1KMR (3D)

1RG3 (3D)

1RG4 (3D)

1SSZ (3D)

2DWF (3D)

Secondary accessions: Q96R04

Explore the universe of human proteins at neXtProt for SFTPB: NX_P07988

SFTPB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_000533.3 NP_942140.2

ENSEMBL proteins:

ENSP00000428719 ENSP00000415347 ENSP00000386346 ENSP00000377409 ENSP00000345161

Human Recombinant Protein Products for SFTPB:

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	Novus Biologicals SFTPB Protein Novus Biologicals SFTPB Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IEA	--
GO:0005737	cytoplasm	--	--
GO:0005764	lysosome	IEA	--
GO:0005771	multivesicular body	--	--
GO:0042599	lamellar body	--	--

SFTPB for ontologies About GeneDecksing

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SFTPB for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR011001 Saposin-like

IPR007856 SapB_1

IPR008138 SapB_2

IPR008373 Saposin

IPR003119 SapA

Graphical View of Domain Structure for InterPro Entry P07988

ProtoNet protein and cluster: P07988

2 Blocks protein families:

IPB008137 Surfactant protein B

IPB008139 Saposin B

UniProtKB/Swiss-Prot: PSPB_HUMAN, P07988

Similarity: Contains 1 saposin A-type domain

Similarity: Contains 3 saposin B-type domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PSPB_HUMAN, P07988

Function: Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the

air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70

millinewtons per meter

Genatlas biochemistry entry for SFTPB:

surfactant-associated glycoprotein b,pulmonary 3 (18kDa),expressed in the alveolar and non ciliated bronchiolar

epithelial cells

Phenotypes:
2 GenomeRNAi human phenotypes for SFTPB:

Decreased influenza A H1N1 (A/

Decreased influenza A/WSN/33 r

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Sftpb):

behavior/neurological

homeostasis/metabolism

mortality/aging

respiratory system

SFTPB for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Sftpb^tm1Jaw for SFTPB

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SFTPB

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		hsa-miR-922 hsa-miR-15a hsa-miR-497 hsa-miR-1301 hsa-miR-424 hsa-miR-378* hsa-miR-195 hsa-miR-16

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFTPB

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SFTPB

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for SFTPB (P07988³ ENSP00000345161⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CTSH	P09668³, ENSP00000220166⁴	I2D: score=1 STRING: ENSP00000220166
KRTAP4-12	Q9BQ66³	I2D: score=1

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	--	--
GO:0006665	sphingolipid metabolic process	IEA	--
GO:0007585	respiratory gaseous exchange	IEA	--
GO:0007623	circadian rhythm	--	--
GO:0009749	response to glucose stimulus	--	--

SFTPB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SFTPB for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SFTPB
10/72 Novoseek chemical compound relationships for SFTPB gene (see all 72) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sinapultide	87.5	8	15805380 (1), 8542150 (1), 15813666 (1), 16871629 (1) (see all 5)
dppg	86.1	39	8038387 (4), 8038385 (3), 7794949 (2), 11423403 (2) (see all 14)
lucinactant	84.3	8	15805380 (2), 15633204 (2), 17394936 (1), 15813666 (1) (see all 5)
dppc	83.4	117	1606172 (7), 18708453 (5), 9355744 (4), 14504839 (4) (see all 37)
survanta	81.6	16	9973546 (1), 17394936 (1), 8825793 (1), 11325728 (1) (see all 7)
popg	76.4	19	1606172 (5), 11423403 (2), 8542150 (1), 17890383 (1) (see all 7)
phospholipid	72.6	94	1606172 (2), 8695661 (2), 11839533 (2), 8038387 (2) (see all 52)
infasurf	69.1	3	16019988 (1), 19436610 (1), 15671432 (1)
phosphatidylcholine	61.7	21	9355744 (3), 12030716 (2), 10333303 (1), 1709859 (1) (see all 12)
1,2-dipalmitoyl-sn-glycero-3-phosphocholine	61.1	3	15805380 (1), 8599660 (1), 19399006 (1)

Search CenterWatch for drugs/clinical trials and news about SFTPB / PSPB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SFTPB gene (2 alternative transcripts):

NM_000542.3 NM_198843.2

Unigene Cluster for SFTPB:

Surfactant protein B

Hs.512690 [show with all ESTs]

Unigene Representative Sequence: NM_000542

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000519937(uc010ysw.1) ENST00000428225 ENST00000409383 ENST00000494165

ENST00000491167 ENST00000473692 ENST00000393822 ENST00000342375(uc002sqi.3 uc002sqj.3 uc002sqh.3)

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		hsa-miR-922 hsa-miR-15a hsa-miR-497 hsa-miR-1301 hsa-miR-424 hsa-miR-378* hsa-miR-195 hsa-miR-16

		SwitchGear 3'UTR luciferase reporter plasmid: SFTPB 3' UTR sequence

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Additional cDNA sequence:

AB439563.1 AB439564.1 AB439565.1 AB439566.1 AK303817.1 AK314947.1 BC032785.1 DQ317589.1

J02761.1 M16764.1 M19097.1

15 DOTS entries:

DT.117753 DT.97813494 DT.95081762 DT.92441272 DT.100748542 DT.91974055 DT.97855718 DT.120961087

DT.40133149 DT.91743739 DT.92395929 DT.95081760 DT.95081761 DT.429781 DT.97794181

24/311 AceView cDNA sequences (see all 311):

T96402 T92454 AA487981 AA358068 AI191363 CA439806 AA487826 AA953082

BM978061 CA444303 AA664149 AI821016 AW276646 AI950867 CA435684 CA434243

CA437348 AI821343 T92189 AA487976 CA437037 N79520 CA450126 T65949

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SFTPB (see all 7) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	·	8d	^	9	^	10	^	11	^	12a	·	12b	·	12c	^	13
SP1:					-						-												-								-						-
SP2:																							-								-						-		-		-
SP3:																							-		-						-
SP4:																															-
SP5:					-

ECgene alternative splicing isoforms for SFTPB

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SFTPB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGGGATGGC

About this image

SFTPB expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Alveoli

Alveolar Epithelial Type 2 Cells

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Lung Epithelial Progenitors (Efficient derivation...)

Lung

Type II pneumocytes (airway epithelial cells) (Derivation of lung s...)

Alveolar type II cells (Derivation of mature...)

Lung

See SFTPB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SFTPB

SOURCE GeneReport for Unigene cluster: Hs.512690

SABiosciences Expression via Pathway-Focused PCR Arrays including SFTPB:

Cell Lineage Identification in human mouse rat

Terminal Differentiation Markers in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SFTPB gene from 3/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	SFTPB⁶	--	36(a)	1 ↔ 1	AAWZ02037276(1118-13671)
zebrafish (Danio rerio)	Actinopterygii	si:ch211-283h6.6⁶ si:ch73-340n8.2⁶	si:ch73-340n8.2	19(a) 17(a)	1 ↔ many 1 ↔ many	5(71749763-71780926) 10(6826587-6833510)
fruit fly (Drosophila melanogaster)	Insecta	Sap-r⁶	Saposin-related	8(a)	possible ortholog	3R(26709186-26714795)

ENSEMBL Gene Tree for SFTPB (if available)
TreeFam Gene Tree for SFTPB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SFTPB gene

PSAPL1² PSAP²

SFTPB for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs137853202^1,2	C	pathogenic	85788269(-)	`TGTGCC/TGCGTG`	4	R C	mis¹		1		NA	2500
rs3024830^1,2	C,F,H	--	85781969(-)	`CAAGCG/ACCAGA`	2	--	ut3¹ ese³		7		NS NA	884
rs200871431^1,2	C	--	85782008(-)	`TCTTCC/TCCCCA`	2	--	ut3¹		0	--	--	--	--
rs113824447^1,2		--	85782238(+)	`ATAGGC/TGGTGG`	2	--	ut3¹		1		CSA	2
rs3024829^1,2	C,F,H	--	85782302(-)	`TCTCCG/ACCATT`	2	--	ut3¹ ese³		6		NS EA	498
rs114238614^1,2	C,F	--	85782961(+)	`TTTATT/GTATTT`	2	--	ut3¹		1		WA	118
rs3024828^1,2	C,F,H	--	85783293(-)	`GACACC/TGTCCT`	2	--	ut3¹ ese³		14		NS EA NA WA	1464
rs3024827^1,2	C,F,H	--	85783394(-)	`AAGCTC/GAGCTG`	2	--	ut3¹ int¹		10		NS EA NA WA CSA	630
rs3024826^1,2	C	--	85783490(-)	`AAAAGG/CGGTTT`	2	--	int¹ ut3¹		2		NS	82
rs3024825^1,2	C	--	85783500(-)	`TTAAG-/CATATATA`	2	--	ut3¹ int¹		2		NS	84

HapMap Linkage Disequilibrium report for SFTPB (85884437 - 85895864 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SFTPB: --
Human Gene Mutation Database (HGMD): SFTPB

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SFTPB for disorders           About GeneDecksing

OMIM gene information: 178640
OMIM disorders: 265120
UniProtKB/Swiss-Prot: PSPB_HUMAN, P07988

Defects in SFTPB are the cause of pulmonary surfactant metabolism dysfunction type 1 (SMDP1) [MIM:265120];

also called pulmonary alveolar proteinosis due to surfactant protein B deficiency. A rare lung disorder due to

impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive

using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive

lipoproteins accumulation in the alveoli results in severe respiratory distress

Genetic variations in SFTPB are a cause of susceptibility to respiratory distress syndrome in premature

infants (RDS) [MIM:267450]. RDS is a lung disease affecting usually premature newborn infants. It is characterized by

deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called

'hyaline membranes'. Note=A variation Ile to Thr at position 131 influences the association between specific alleles

of SFTPA1 and respiratory distress syndrome in premature infants

20/48 diseases for SFTPB (see all 48): About MalaCards

pulmonary alveolar proteinosis pulmonary surfactant metabolism dysfunction alpha 1-antitrypsin deficiency newborn respiratory distress syndrome

hermansky-pudlak syndrome congenital pulmonary alveolar proteinosis alveolar capillary dysplasia patent ductus arteriosus

non-small cell lung carcinoma respiratory failure sclerosing hemangioma congenital diaphragmatic hernia

bronchopulmonary dysplasia malignant mesothelioma pulmonary sclerosing hemangioma neonatal respiratory failure

surfactant deficiency chronic obstructive pulmonary disease hemangioma idiopathic pulmonary fibrosis

3 diseases from the University of Copenhagen DISEASES database for SFTPB:

Respiratory failure Pulmonary alveolar proteinosis Sclerosing hemangioma

10/57 Novoseek disease relationships for SFTPB gene (see all 57) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
respiratory distress syndrome	83.1	53	12483294 (2), 17581675 (2), 16549540 (2), 18353230 (2) (see all 35)
pulmonary alveolar proteinosis	81.5	9	15358702 (2), 9793979 (1), 10445627 (1), 20005435 (1) (see all 5)
respiratory failure	72.9	54	9506635 (2), 15027668 (2), 15190959 (2), 10571948 (2) (see all 31)
lung diseases	70.7	48	7491219 (3), 14977415 (3), 10960490 (2), 15790313 (2) (see all 26)
hyaline membrane disease	68.9	1	11041444 (1)
lung diseases interstitial	68.8	18	19220077 (2), 15737281 (1), 19824815 (1), 20461691 (1) (see all 12)
bronchopulmonary dysplasia	67.3	1	10493923 (1)
bronchoalveolar lavage fluid	61	19	15639455 (3), 7582290 (2), 15049696 (1), 9042125 (1) (see all 11)
acute respiratory distress	56	7	16871629 (1), 17505704 (1), 11076040 (1), 19132247 (1) (see all 7)
adenocarcinoma lung	52.6	9	12930693 (3), 15614737 (1), 12698189 (1), 9128293 (1) (see all 6)

Genetic Association Database (GAD): SFTPB
Human Genome Epidemiology (HuGE) Navigator: SFTPB (39 documents)

Export disorders for SFTPB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SFTPB gene, integrated from 9 sources (see all 523):
(articles sorted by number of sources associating them with SFTPB)

Utopia: connect your pdf to the dynamic
world of online information

Polymorphisms of human SP-A, SP-B, and SP-D genes: association of SP- B Thr131Ile with ARDS. (PubMed id 11076040)^{1, 2, 4, 9} Lin Z....Floros J. (2000)
Surfactant proteins A and B as interactive genetic determinants of neonatal respiratory distress syndrome. (PubMed id 11063734)^{1, 2, 4, 9} Haataja R.... Hallman M. (2000)
Structure and organization of the gene encoding human pulmonary surfactant proteolipid SP-B. (PubMed id 2924687)^{1, 2, 3} Pilot-Matias T.J....Whitsett J.A. (1989)
Association between surfactant protein B + 1580 polymorphism and the risk of respiratory failure in adults with community-acquired pneumonia. (PubMed id 15190959)^{1, 4, 9} Quasney M.W....Wunderink R.G. (2004)
Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis. (PubMed id 13680361)^{1, 4, 9} Selman M.... Floros J. (2003)
Chromosomal localization of three pulmonary surfactan t protein genes in the mouse. (PubMed id 1346779)^{1, 3, 9} Moore K.J....Copeland N.G. (1992)
Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations. (PubMed id 15817713)^{1, 4, 9} Hersh C.P....Silverman E.K. (2005)
Polymorphism in the surfactant protein-B gene, gender, and the risk of direct pulmonary injury and ARDS. (PubMed id 14718442)^{1, 4, 9} Gong M.N....Christiani D.C. (2004)
Surfactant protein B polymorphism and respiratory distress syndrome in premature twins. (PubMed id 12483294)^{1, 4, 9} Marttila R....Hallman M. (2003)
Polymorphisms of surfactant protein B encoding gene: modifiers of the course of neonatal respiratory distress syndrome? (PubMed id 12424586)^{1, 4, 9} Makri V....Gortner L. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6439	HGNC: 10801	AceView: SFTPB	Ensembl:ENSG00000168878	euGenes: HUgn6439
ECgene: SFTPB	H-InvDB: SFTPB

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SFTPB	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SFTPB
SeattleSNPs	http://pga.gs.washington.edu/data/sftpb/

Intellectual Property for SFTPB gene
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Patent Information for SFTPB gene:
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surfactant protein B

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