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SFTPA2 Gene

protein-coding   GIFtS: 52
GCID: GC10M081305

Surfactant Protein A2

(Previous names: surfactant, pulmonary-associated protein A2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Surfactant Protein A21 2     Pulmonary-Associated Protein A2A1
COLEC52 3 5     surfactant1
Alveolar Proteinosis Protein2 3     Surfactant, Pulmonary-Associated Protein A21
35 KDa Pulmonary Surfactant-Associated Protein2 3     SPAII2
PSAP2 3     Collectin 52
PSP-A2 3     Pulmonary Surfactant-Associated Protein A22
PSPA2 3     Surfactant, Pulmonary-Associated Protein A2A2
SFTP12 3     Collectin-53
SFTPA2B2 3     SFTPA3
SP-A2 3     SP-A23
SPA22 5     

External Ids:    HGNC: 107991   Entrez Gene: 7292382   Ensembl: ENSG000001853037   OMIM: 1786425   UniProtKB: Q8IWL13   

Export aliases for SFTPA2 gene to outside databases

Previous GC identifers: GC10M080272 GC10M080525 GC10M081528 GC10M080980 GC10M075310


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SFTPA2 Gene:
This gene is one of several genes encoding pulmonary-surfactant associated proteins (SFTPA) located on chromosome
10. Mutations in this gene and a highly similar gene located nearby, which affect the highly conserved
carbohydrate recognition domain, are associated with idiopathic pulmonary fibrosis. The current version of the
assembly displays only a single centromeric SFTPA gene pair rather than the two gene pairs shown in the previous
assembly which were thought to have resulted from a duplication. (provided by RefSeq, Sep 2009)

GeneCards Summary for SFTPA2 Gene:
SFTPA2 (surfactant protein A2) is a protein-coding gene. Diseases associated with SFTPA2 include allergic bronchopulmonary aspergillosis, and idiopathic pulmonary fibrosis. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is SFTPA1.

UniProtKB/Swiss-Prot: SFPA2_HUMAN, Q8IWL1
Function: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface
tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SFTPA2 gene promoter:
         MZF-1   GR   NCX/Ncx   GR-alpha   Roaz   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSFTPA2 promoter sequence
   Search Chromatin IP Primers for SFTPA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SFTPA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.3   Ensembl cytogenetic band:  10q22.3   HGNC cytogenetic band: 10q22.3

SFTPA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SFTPA2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M081305:  view genomic region     (about GC identifiers)

Start:
81,315,608 bp from pter      End:
81,320,163 bp from pter
Size:
4,556 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SFPA2_HUMAN, Q8IWL1 (See protein sequence)
Recommended Name: Pulmonary surfactant-associated protein A2 precursor  
Size: 248 amino acids; 26182 Da
Subunit: Oligomeric complex of 6 set of homotrimers
Miscellaneous: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated
proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins
(SP-B and SP-C)
Secondary accessions: A4QPA7 B2RXI6 B2RXK9 C9J9I7 E3VLC6 E3VLC7 E3VLC8 E3VLC9 P07714 Q14DV3
Q5RIR8 Q5RIR9

Explore the universe of human proteins at neXtProt for SFTPA2: NX_Q8IWL1

Explore proteomics data for SFTPA2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn207

  • See SFTPA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001092138.1  
    ENSEMBL proteins: 
     ENSP00000361400   ENSP00000397375   ENSP00000473275   ENSP00000361402  
    Reactome Protein details: Q8IWL1

    SFTPA2 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    SFTPA2 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for SFTPA2

    SFTPA2 Assay Products:

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    GenScript Custom Assay Services for SFTPA2
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    COLEC: Collectins

    5 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR018378 C-type_lectin_CS
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin
     IPR008160 Collagen

    Graphical View of Domain Structure for InterPro Entry Q8IWL1

    ProtoNet protein and cluster: Q8IWL1

    1 Blocks protein domain: IPB008160 Collagen triple helix repeat

    UniProtKB/Swiss-Prot: SFPA2_HUMAN, Q8IWL1
    Similarity: Belongs to the SFTPA family
    Similarity: Contains 1 C-type lectin domain
    Similarity: Contains 1 collagen-like domain


    SFTPA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SFPA2_HUMAN, Q8IWL1
    Function: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface
    tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030246carbohydrate binding IEA--
         
    SFTPA2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SFTPA2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SFTPA2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SFTPA2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SFTPA2

    miRNA
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    Block miRNA regulation of human, mouse, rat SFTPA2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SFTPA2:
    hsa-miR-4291
    SwitchGear 3'UTR luciferase reporter plasmidSFTPA2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SFTPA2
    Predesigned siRNA for gene silencing in human, mouse, rat SFTPA2

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: SFTPA2 (NM_001098668)
    Sino Biological Human cDNA Clone for SFTPA2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SFTPA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFTPA2

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFTPA2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SFPA2_HUMAN, Q8IWL1: Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface
    film
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton1
    endoplasmic reticulum1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005581collagen IEA--
    GO:0005615extracellular space IEA--

    SFTPA2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SFTPA2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Phagosome
    Phagosome
    2Pertussis
    Pertussis
    3FOXA1 transcription factor network
    FOXA1 transcription factor network

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SFTPA2
        FOXA1 transcription factor network


    1 Reactome Pathway for SFTPA2
        Signal regulatory protein (SIRP) family interactions


    2 Kegg Pathways  (Kegg details for SFTPA2):
        Phagosome
    Pertussis


    SFTPA2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SFTPA2
    Interactions:

        GeneGlobe Interaction Network for SFTPA2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for SFTPA2 (Q8IWL13 ENSP000003614004) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LY96Q9Y6Y93I2D: score=1 
    TLR4O002063I2D: score=1 
    SFTPA1ENSP000003613824STRING: ENSP00000361382
    CD93ENSP000002460064STRING: ENSP00000246006
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007585respiratory gaseous exchange IEA--

    SFTPA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SFTPA2 (SFPA2)

    1 HMDB Compound for SFTPA2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SFTPA2 gene: 
    NM_001098668.2  

    Unigene Cluster for SFTPA2:

    Surfactant protein A2
    Hs.523084  [show with all ESTs]
    Unigene Representative Sequence: NM_001098668
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372325(uc001kal.4 uc001kan.4) ENST00000417041(uc001kam.2)
    ENST00000492049 ENST00000372327

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SFTPA2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SFTPA2:
    hsa-miR-4291
    SwitchGear 3'UTR luciferase reporter plasmidSFTPA2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SFTPA2
    Predesigned siRNA for gene silencing in human, mouse, rat SFTPA2
    Clone
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    OriGene clones in human, mouse for SFTPA2 (see all 4)
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    GenScript: all cDNA clones in your preferred vector: SFTPA2 (NM_001098668)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SFTPA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFTPA2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SFTPA2
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat SFTPA2
      QuantiTect SYBR Green Assays in human, mouse, rat SFTPA2
      QuantiFast Probe-based Assays in human, mouse, rat SFTPA2

    Additional mRNA sequence: 

    AK225599.1 AK298041.1 AK298074.1 AK298114.1 AK313179.1 AK316192.1 BC111571.1 BC139727.1 
    BC157866.1 BC157890.1 HQ021421.1 HQ021422.2 HQ021423.2 HQ021424.1 HQ021425.2 HQ021426.1 
    HQ021427.1 HQ021428.2 HQ021429.2 HQ021430.1 HQ021431.2 HQ021432.1 K03475.1 S69680.1 
    S69683.1 S69687.1 S69688.1 S69791.1 

    14 DOTS entries:

    DT.418328  DT.97784300  DT.97827098  DT.92330441  DT.91765535  DT.91765534  DT.121286766  DT.121286855 
    DT.95374233  DT.91765555  DT.95374231  DT.95374232  DT.97832746  DT.97833272 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SFTPA2 expression in normal human tissues (normalized intensities)      SFTPA2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCCAGCCA
    SFTPA2 Expression
    About this image


    SFTPA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Lung (Respiratory System)
             Alveolar type II cells
    SFTPA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SFTPA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523084
        Custom PCR Arrays for SFTPA2
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat SFTPA2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFTPA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SFTPA2 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SFTPA11 surfactant, pulmonary-associated protein A1 53.67(n)
    42.66(a)
      395308  NM_204606.1  NP_989937.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    50(a)
    1 → many
    GL343233.1(1634950-1643878)
    zebrafish
    (Danio rerio)
    Actinopterygii hbl46
    hbl26
    (see all 5)
    hexose-binding lectin 2
    (see all 5)
    31(a)
    30(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    2(37618223-37621667) ENSDARG00000054202
    2(37631017-37632321) ENSDARG00000094681
            Species with no ortholog for SFTPA2

    ENSEMBL Gene Tree for SFTPA2 (if available)
    TreeFam Gene Tree for SFTPA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SFTPA2 gene
    SFTPA12  COLEC112  SFTPD2  COLEC102  MBL22  
    6 SIMAP similar genes for SFTPA2 using alignment to 3 protein entries:     SFPA2_HUMAN (see all proteins):
    SP-2A    SP-A1    SP-A2    SFTPA1    MBL2    SFTPD

    SFTPA2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    SFPA2_HUMAN, Q8IWL1: At least 6 alleles of SFTPA2 are known: 1A, 1A(0), 1A(1), 1A(2), 1A(3) and 1A(4). The sequence shown
    is that of allele 1A(0)


    Selected SNPs for SFTPA2 (see all 330)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0635204
    Pulmonary fibrosis, idiopathic (IPF)4--see VAR_0635202 G V mis40--------
    VAR_0635194
    Pulmonary fibrosis, idiopathic (IPF)4--see VAR_0635192 F S mis40--------
    rs178861811,2
    F--75316761(-) CAATA-/CAAA  
            
    CAAAC
    1 -- us2k12Minor allele frequency- CAAA:0.09NS 90
    rs178811771,2
    C,F--81321504(-) ATTTGG/-AGTTA 1 -- us2k12Minor allele frequency- -:0.07NS 92
    rs178868181,2
    C,F--81687881(-) CCACTA/TCTCCC 1 -- ds50012Minor allele frequency- T:0.05NS 90
    rs178783061,2
    C,F--81687976(-) CACTGC/TCCCAT 1 -- ds50012Minor allele frequency- T:0.06NS 90
    rs1917528771,2
    --81687996(+) CAAGCC/TGACAT 1 -- ds50010--------
    rs178785341,2
    C,F--81687997(-) CATGTC/TGGCTT 1 -- ds50012Minor allele frequency- T:0.01NS 90
    rs1468733461,2
    --81688034(+) GAACTC/GAGCCC 1 -- ds50010--------
    rs1830999771,2
    --81688087(+) GGCTGC/TGCAGA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SFTPA2 (81315608 - 81320163 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SFTPA2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv436110CNV Deletion17901297
    nsv8694CNV Gain18304495
    essv24085CNV CNV17122850

    Human Gene Mutation Database (HGMD): SFTPA2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SFTPA2
    DNA2.0 Custom Variant and Variant Library Synthesis for SFTPA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 178642   
    OMIM disorders: 178500  
    UniProtKB/Swiss-Prot: SFPA2_HUMAN, Q8IWL1
  • Pulmonary fibrosis, idiopathic (IPF) [MIM:178500]: A lung disease characterized by shortness of breath,
    radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on
    biopsy. In some cases, the disorder can be rapidly progressive and characterized by sequential acute lung injury
    with subsequent scarring and end-stage lung disease. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 20 diseases for SFTPA2:    About MalaCards
    allergic bronchopulmonary aspergillosis    idiopathic pulmonary fibrosis    pulmonary fibrosis    pulmonary edema
    pulmonary fibrosis, familial    aspergillosis    bronchopulmonary dysplasia    otitis media
    pulmonary tuberculosis    eosinophilia    allergic rhinitis    rhinitis
    tuberculosis    pertussis    cystic fibrosis    lung cancer
    alzheimer's disease    asthma    multiple myeloma    myeloma

    2 diseases from the University of Copenhagen DISEASES database for SFTPA2:
    Aspergillosis     Lung disease

    SFTPA2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): SFTPA2
    Human Genome Epidemiology (HuGE) Navigator: SFTPA2 (22 documents)

    Export disorders for SFTPA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SFTPA2 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with SFTPA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human SP-A1 (SFTPA1) variant-specific 3' UTRs and poly(A) tail differentially affect the in vitro translation of a reporter gene. (PubMed id 20693318)1, 2 Silveyra P.... Floros J. (Am. J. Physiol. 2010)
    2. Polymorphisms in the surfactant protein a gene are associated with the susceptibility to recurrent urinary tract infection in chinese women. (PubMed id 20448439)1, 4 Liu J....Ding G. (Tohoku J. Exp. Med. 2010)
    3. Surfactant protein A and D gene polymorphisms and protein expression in victims of sudden infant death. (PubMed id 18983439)1, 4 Stray-Pedersen A....Rognum T.O. (Acta Paediatr. 2009)
    4. Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer. (PubMed id 19100526)1, 2 Wang Y.... Garcia C.K. (Am. J. Hum. Genet. 2009)
    5. Comprehensive linkage and association analyses identify haplotype, near to the TNFSF15 gene, significantly associated with spondyloarthritis. (PubMed id 19543369)1, 4 Zinovieva E....Breban M. (PLoS Genet. 2009)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    9. Characterization of a second human pulmonary surfactant-associated protein SP-A gene. (PubMed id 1372511)1, 2 Katyal S.L.... Locker J.L. (Am. J. Respir. Cell Mol. Biol. 1992)
    10. Studies of the structure of lung surfactant protein SP-A. (PubMed id 2610270)1, 2 Haagsman H.P.... Clements J.A. (Am. J. Physiol. 1989)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 729238 HGNC: 10799 Ensembl:ENSG00000185303 euGenes: HUgn729238 ECgene: SFTPA2 Kegg: 729238
    H-InvDB: SFTPA2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SFTPA2 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/sftpa2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SFTPA2 gene:
    Search GeneIP for patents involving SFTPA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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