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SFTA3 Gene

protein-coding   GIFtS: 32
GCID: GC14M036942

Surfactant Associated 3

(Previous name: surfactant associated protein H)
(Previous symbol: SFTPH)
  Search for SFTA3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Surfactant Associated 31 2
SFTPH1 2 3
Surfactant Associated Protein H1 2
Surfactant-Associated Protein 32 3
Surfactant-Associated Protein H2 3
Putative Protein SFTA32

External Ids:    HGNC: 183871   Entrez Gene: 2539702   Ensembl: ENSG000002294157   UniProtKB: P0C7M33   

Export aliases for SFTA3 gene to outside databases

Previous GC identifers: GC14M036014 GC14M017057


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SFTA3 Gene:
SFTA3 (surfactant associated 3) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the SFTA3 gene promoter:
         Egr-1   IRF-1   Nkx2-5   Max   POU2F1   POU2F1a   STAT3   AP-2alpha   c-Myc   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SFTA3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SFTA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q13.3   Ensembl cytogenetic band:  14q13.3   HGNC cytogenetic band: 14q13.3

SFTA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SFTA3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M036942:  view genomic region     (about GC identifiers)

Start:
36,942,493 bp from pter      End:
36,983,034 bp from pter
Size:
40,542 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SFTA3_HUMAN, P0C7M3 (See protein sequence)
Recommended Name: Putative protein SFTA3  
Size: 94 amino acids; 10526 Da

Explore the universe of human proteins at neXtProt for SFTA3: NX_P0C7M3

REFSEQ proteins: NP_001094811.1  
ENSEMBL proteins: 
 ENSP00000428331   ENSP00000428247   ENSP00000427853   ENSP00000428198   ENSP00000429830  

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Search eBioscience for ELISAs for SFTA3 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: P0C7M3


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     1 GenomeRNAi human phenotype for SFTA3:
 High actin ratio cells 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SFTA3
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hsa-miR-320a hsa-miR-548p hsa-miR-1226 hsa-miR-320d hsa-miR-29c hsa-miR-29a hsa-miR-488 hsa-miR-3161
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
extracellular2
nucleus1
peroxisome1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathway & Disease-focused RT2 Profiler PCR Array including SFTA3: 
          Lung Cancer in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for SFTA3

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SFTA3



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for SFTA3 gene: 
NM_001101341.1  

Unigene Cluster for SFTA3:

Surfactant associated 3
Hs.509165  [show with all ESTs]
Unigene Representative Sequence: AK027147
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000519052 ENST00000518529(uc001wtr.3 uc001wtq.3) ENST00000518002
ENST00000521114 ENST00000518987 ENST00000524122 ENST00000518446 ENST00000418548
ENST00000521380
miRNA
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hsa-miR-320a hsa-miR-548p hsa-miR-1226 hsa-miR-320d hsa-miR-29c hsa-miR-29a hsa-miR-488 hsa-miR-3161
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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Clone
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GenScript: all cDNA clones in your preferred vector: SFTA3 (NM_001101341)
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Primer
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  QuantiFast Probe-based Assays in human, mouse, rat SFTA3

Additional mRNA sequence: 

AK027147.1 AY102071.1 BC042093.1 BC129834.1 

6 DOTS entries:

DT.91934576  DT.99927627  DT.40116797  DT.92419432  DT.95303523  DT.40118569 

Selected AceView cDNA sequences (see all 125):

BU682404 AI458219 AI698112 AI458394 BE503651 BU688334 BC042093 BQ943821 
CB850780 BM970287 BM973864 CA311740 CB852634 AI954875 CR600885 BE796718 
BM996453 CR604190 AY102071 NM_003317 U19756 CA502940 BC006221 CA438683 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SFTA3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGTAAAATTT
SFTA3 Expression
About this image

SFTA3 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.509165
    Pathway & Disease-focused RT2 Profiler PCR Array including SFTA3: 
          Lung Cancer in human mouse rat

Primer
Products:
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFTA3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and chimp.

Orthologs for SFTA3 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia SFTA31 surfactant associated 3 98.58(n)
96.81(a)
  452866  XM_003952476.1  XP_003952525.1 


ENSEMBL Gene Tree for SFTA3 (if available)
TreeFam Gene Tree for SFTA3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SFTA3 (see all 717)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1811797751,2
--36942042(+) TGTAAA/GTAGAT 1 -- int10--------
rs1838942681,2
--36942643(+) ACTCAG/TGTTTA 1 -- ut310--------
rs1882301881,2
--36942651(+) TTATTA/GTGAAG 1 -- ut310--------
rs1820562831,2
--36942884(+) AAGCTG/TTTTGA 1 -- ut310--------
rs71596991,2
C,F,A,H--36942909(+) TCAAGA/TTGGTG 1 -- ut3124Minor allele frequency- T:0.09NS EA NA WA 2648
rs1388432371,2
--36943000(+) TTGACA/GTAGAC 1 -- ut310--------
rs2001056531,2
C--36943072(+) GCAGTA/GTGAAT 2 H syn11Minor allele frequency- G:0.00EU 569
rs2008904851,2
--36943126(+) AGACAA/TGGTAC 1 -- int10--------
rs1159345561,2
F--36943179(+) AATAGG/TACTTT 1 -- int11Minor allele frequency- T:0.02WA 118
rs1864453221,2
--36943187(+) TTTAGC/TAATTA 1 -- int10--------

HapMap Linkage Disequilibrium report for SFTA3 (36942493 - 36983034 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for SFTA3:    About this table    
Variant IDTypeSubtypePubMed ID
esv990813CNV Deletion20482838
esv2748601CNV Deletion23290073
esv2748603CNV Deletion23290073
esv2748602CNV Deletion23290073
nsv832771CNV Loss17160897
nsv826922CNV Gain20364138

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SFTA3
DNA2.0 Custom Variant and Variant Library Synthesis for SFTA3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with SFTA3           About GenesLikeMe

Genetic Association Database (GAD): SFTA3
Human Genome Epidemiology (HuGE) Navigator: SFTA3 (3 documents)

Export disorders for SFTA3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SFTA3 gene integrated from 10 sources:
(articles sorted by number of sources associating them with SFTA3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
  2. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (Nature 2003)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  6. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 253970 HGNC: 18387 AceView: TITF1 Ensembl:ENSG00000229415 euGenes: HUgn253970
ECgene: SFTA3 H-InvDB: SFTA3

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SFTA3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SFTA3 gene:
Search GeneIP for patents involving SFTA3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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