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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SFTA3 Gene

protein-coding GIFtS: 33
GCID: GC14M036942

surfactant associated 3

(Previous name: surfactant associated protein H )
(Previous symbol: SFTPH)

Explore 1 disease affiliated with
SFTA3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Surfactant Associated 3¹ ²
SFTPH¹ ² ³
Surfactant Associated Protein H¹ ²
Surfactant-Associated Protein 3² ³
Surfactant-Associated Protein H² ³
Putative Protein SFTA3²

External Ids:	HGNC: 18387¹	Entrez Gene: 253970²	Ensembl: ENSG00000229415⁷	UniProtKB: P0C7M3³

Export aliases for SFTA3 gene to outside databases

Previous GC identifers: GC14M036014 GC14M017057

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SFTA3 gene promoter:
Egr-1 IRF-1 Nkx2-5 Max POU2F1 POU2F1a STAT3 AP-2alpha c-Myc AP-2alphaA
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for SFTA3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SFTA3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q13.3 Ensembl cytogenetic band: 14q13.3 HGNC cytogenetic band: 14q13.3

SFTA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SFTA3 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M036942: view genomic region (about GC identifiers)

Start:	36,942,493 bp from pter	End:	36,983,034 bp from pter
Size:	40,542 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SFTA3_HUMAN, P0C7M3 (See protein sequence)

Recommended Name: Putative protein SFTA3

Size: 94 amino acids; 10526 Da

Explore the universe of human proteins at neXtProt for SFTA3: NX_P0C7M3

SFTA3 Protein expression data from MOPED and PaxDb: --

REFSEQ proteins: NP_001094811.1

ENSEMBL proteins:

ENSP00000428331 ENSP00000428247 ENSP00000427853 ENSP00000428198 ENSP00000429830

Human Recombinant Protein Products for SFTA3:

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: P0C7M3

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Phenotypes:
1 GenomeRNAi human phenotype for SFTA3:

High actin ratio cells

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SFTA3

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		hsa-miR-320a hsa-miR-548p hsa-miR-1226 hsa-miR-320d hsa-miR-29c hsa-miR-29a hsa-miR-488 hsa-miR-3161

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFTA3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SFTA3

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SFTA3
Search CenterWatch for drugs/clinical trials and news about SFTA3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SFTA3 gene:

NM_001101341.1

Unigene Cluster for SFTA3:

Surfactant associated 3

Hs.509165 [show with all ESTs]

Unigene Representative Sequence: AK027147

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000519052 ENST00000518529(uc001wtr.3 uc001wtq.3) ENST00000518002

ENST00000521114 ENST00000518987 ENST00000524122 ENST00000518446 ENST00000418548

ENST00000521380

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		8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate SFTA3 (see all 14):
		hsa-miR-320a hsa-miR-548p hsa-miR-1226 hsa-miR-320d hsa-miR-29c hsa-miR-29a hsa-miR-488 hsa-miR-3161

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SFTA3 OriGene shRNA RFP: SFTA3 OriGene siRNA: SFTA3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SFTA3
		Sirion Biotech Custom design and validation of potent shRNA sequences against SFTA3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFTA3 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFTA3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SFTA3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SFTA3

Additional cDNA sequence:

AK027147.1 AY102071.1 BC042093.1 BC129834.1

6 DOTS entries:

DT.91934576 DT.99927627 DT.40116797 DT.92419432 DT.95303523 DT.40118569

24/125 AceView cDNA sequences (see all 125):

AI954875 CR600885 BE503651 U19756 BC006221 BQ943821 BM970287 BM973864

CA311740 CB852634 BC042093 BM973315 AI698112 BU688334 CA502940 BU682404

AI458219 CA438683 AI458394 CB850780 BE796718 CR604190 BM996453 NM_003317

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SFTA3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTAAAATTT

About this image

SFTA3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

N2/LSB/S/F8-induced cells (Generation of midbra...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Genevestigator expression for SFTA3

SOURCE GeneReport for Unigene cluster: Hs.509165

SABiosciences Expression via Pathway-Focused PCR Array including SFTA3:

Lung Cancer in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SFTA3 Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFTA3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for SFTA3 (if available)
TreeFam Gene Tree for SFTA3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs181179775^1,2		--	36942042(+)	`TGTAAA/GTAGAT`	1	--	int¹		0	--	--	--	--
rs183894268^1,2		--	36942643(+)	`ACTCAG/TGTTTA`	1	--	ut3¹		0	--	--	--	--
rs188230188^1,2		--	36942651(+)	`TTATTA/GTGAAG`	1	--	ut3¹		0	--	--	--	--
rs182056283^1,2		--	36942884(+)	`AAGCTG/TTTTGA`	1	--	ut3¹		0	--	--	--	--
rs7159699^1,2	C,F,A,H	--	36942909(+)	`TCAAGA/TTGGTG`	1	--	ut3¹		24		NS EA NA WA	2648
rs138843237^1,2		--	36943000(+)	`TTGACA/GTAGAC`	1	--	ut3¹		0	--	--	--	--
rs200890485^1,2		--	36943126(+)	`AGACAA/TGGTAC`	1	--	int¹		0	--	--	--	--
rs115934556^1,2	F	--	36943179(+)	`AATAGG/TACTTT`	1	--	int¹		1		WA	118
rs186445322^1,2		--	36943187(+)	`TTTAGC/TAATTA`	1	--	int¹		0	--	--	--	--
rs4381495^1,2	H	--	36943206(+)	`TATTTC/TTAAAT`	1	--	int¹		4		NS EA	420

HapMap Linkage Disequilibrium report for SFTA3 (36942493 - 36983034 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SFTA3: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SFTA3

DNA2.0 Custom Variant and Variant Library Synthesis for SFTA3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SFTA3 for disorders About GeneDecksing

1 disease for SFTA3: About MalaCards

lung cancer

1 disease from the University of Copenhagen DISEASES database for SFTA3:

Congenital hypothyroidism

Human Genome Epidemiology (HuGE) Navigator: SFTA3 (3 documents)

Export disorders for SFTA3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SFTA3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SFTA3)

Utopia: connect your pdf to the dynamic
world of online information

Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)² Heilig R.... Weissenbach J. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
The sequence of the human genome. (PubMed id 11181995)¹ Venter J.C.... Zhu X. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 253970	HGNC: 18387	AceView: TITF1	Ensembl:ENSG00000229415	euGenes: HUgn253970
ECgene: SFTA3	H-InvDB: SFTA3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SFTA3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SFTA3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SFTA3 gene:
Search GeneIP for patents involving SFTA3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SFTA3 gene at Home site.

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SFTA3 Gene

surfactant associated 3

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SFTA3 Gene

surfactant associated 3

Aliasesfor SFTA3 gene

Summariesfor SFTA3 gene

Genomic Viewsfor SFTA3 gene

Proteinsfor SFTA3 gene

Protein Domains /Familiesfor SFTA3 gene

Functionfor SFTA3 gene

Pathways & Interactionsfor SFTA3 gene

Drugs & Compoundsfor SFTA3 gene

Transcriptsfor SFTA3 gene

Expression for SFTA3 gene

Orthologsfor SFTA3 gene

Paralogsfor SFTA3 gene

Genomic Variantsfor SFTA3 gene

Disorders / Diseasesfor SFTA3 gene

Publicationsfor SFTA3 gene

External Searches for SFTA3 gene

Genome Databases showing SFTA3 gene

Other Databases showing SFTA3 gene

Specialized Databases showing SFTA3 gene

Intellectual Propertyfor SFTA3 gene

Productsfor SFTA3 gene

View Random Gene

Aliases
for SFTA3 gene

Summaries
for SFTA3 gene

Genomic Views
for SFTA3 gene

Proteins
for SFTA3 gene

Protein Domains /
Families
for SFTA3 gene

Function
for SFTA3 gene

Pathways & Interactions
for SFTA3 gene

Drugs & Compounds
for SFTA3 gene

Transcripts
for SFTA3 gene

Expression
for SFTA3 gene

Orthologs
for SFTA3 gene

Paralogs
for SFTA3 gene

Genomic Variants
for SFTA3 gene

Disorders / Diseases
for SFTA3 gene

Publications
for SFTA3 gene

Intellectual Property
for SFTA3 gene

Products
for SFTA3 gene