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Aliases for SFTA3 Gene

Aliases for SFTA3 Gene

  • Surfactant Associated 3 2 3 5
  • Surfactant-Associated Protein H 3 4
  • SFTPH 3 4
  • SP-H 3 4
  • Nkx2.1-Associated Noncoding Intergenic RNA 3
  • Surfactant Associated Protein H 2
  • Surfactant-Associated Protein 3 3
  • Putative Protein SFTA3 3
  • NANCI 3

External Ids for SFTA3 Gene

Previous HGNC Symbols for SFTA3 Gene

  • SFTPH

Previous GeneCards Identifiers for SFTA3 Gene

  • GC14M036014
  • GC14M036942
  • GC14M017057

Summaries for SFTA3 Gene

GeneCards Summary for SFTA3 Gene

SFTA3 (Surfactant Associated 3) is a Protein Coding gene. Diseases associated with SFTA3 include Pulmonary Surfactant Metabolism Dysfunction. Among its related pathways are Diseases of metabolism and Transport to the Golgi and subsequent modification.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFTA3 Gene

Genomics for SFTA3 Gene

Regulatory Elements for SFTA3 Gene

Enhancers for SFTA3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SFTA3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SFTA3 Gene

Chromosome:
14
Start:
36,473,288 bp from pter
End:
36,513,829 bp from pter
Size:
40,542 bases
Orientation:
Minus strand

Genomic View for SFTA3 Gene

Genes around SFTA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFTA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFTA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFTA3 Gene

Proteins for SFTA3 Gene

  • Protein details for SFTA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C7M3-SFTA3_HUMAN
    Recommended name:
    Surfactant-associated protein 3
    Protein Accession:
    P0C7M3

    Protein attributes for SFTA3 Gene

    Size:
    94 amino acids
    Molecular mass:
    10526 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SFTA3 Gene

Post-translational modifications for SFTA3 Gene

No Post-translational modifications

Other Protein References for SFTA3 Gene

No data available for DME Specific Peptides for SFTA3 Gene

Domains & Families for SFTA3 Gene

Protein Domains for SFTA3 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for SFTA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SFTA3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SFTA3 Gene

Function for SFTA3 Gene

Molecular function for SFTA3 Gene

UniProtKB/Swiss-Prot Induction:
By lipopolysaccharides (LPS). Down-regulated by cytokines IL1B and IL23.

Phenotypes for SFTA3 Gene

GenomeRNAi human phenotypes for SFTA3:
genes like me logo Genes that share phenotypes with SFTA3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SFTA3 Gene

Localization for SFTA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFTA3 Gene

Cytoplasm. Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SFTA3 Gene COMPARTMENTS Subcellular localization image for SFTA3 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
cytosol 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SFTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0042599 lamellar body TAS --
GO:0045334 clathrin-coated endocytic vesicle TAS --
genes like me logo Genes that share ontologies with SFTA3: view

Pathways & Interactions for SFTA3 Gene

genes like me logo Genes that share pathways with SFTA3: view

Interacting Proteins for SFTA3 Gene

Gene Ontology (GO) - Biological Process for SFTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with SFTA3: view

No data available for SIGNOR curated interactions for SFTA3 Gene

Drugs & Compounds for SFTA3 Gene

No Compound Related Data Available

Transcripts for SFTA3 Gene

Unigene Clusters for SFTA3 Gene

Surfactant associated 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SFTA3 Gene

No ASD Table

Relevant External Links for SFTA3 Gene

GeneLoc Exon Structure for
SFTA3
ECgene alternative splicing isoforms for
SFTA3

Expression for SFTA3 Gene

mRNA expression in normal human tissues for SFTA3 Gene

mRNA differential expression in normal tissues according to GTEx for SFTA3 Gene

This gene is overexpressed in Thyroid (x28.2) and Lung (x21.3).

Protein differential expression in normal tissues from HIPED for SFTA3 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SFTA3 Gene



Protein tissue co-expression partners for SFTA3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SFTA3 Gene:

SFTA3

SOURCE GeneReport for Unigene cluster for SFTA3 Gene:

Hs.509165

mRNA Expression by UniProt/SwissProt for SFTA3 Gene:

P0C7M3-SFTA3_HUMAN
Tissue specificity: Found (at protein level) in lung alveolar cells type I and II, as well as alveolar macrophages.
genes like me logo Genes that share expression patterns with SFTA3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SFTA3 Gene

Orthologs for SFTA3 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SFTA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SFTA3 34
  • 98.58 (n)
  • 96.81 (a)
SFTA3 35
  • 89 (a)
OneToOne
Species where no ortholog for SFTA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SFTA3 Gene

ENSEMBL:
Gene Tree for SFTA3 (if available)
TreeFam:
Gene Tree for SFTA3 (if available)

Paralogs for SFTA3 Gene

No data available for Paralogs for SFTA3 Gene

Variants for SFTA3 Gene

Sequence variations from dbSNP and Humsavar for SFTA3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1535340 -- 36,514,593(-) TGTGG(C/T)ACCCT upstream-variant-2KB
rs1535341 -- 36,514,418(-) TCAAT(C/T)ACGCT upstream-variant-2KB
rs1535342 -- 36,513,860(-) AAAGC(G/T)GCTCC upstream-variant-2KB
rs7142010 -- 36,486,517(+) TTTCT(A/G)TAAAT intron-variant
rs1885122 -- 36,504,170(-) GGGGT(C/G)GGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SFTA3 Gene

Variant ID Type Subtype PubMed ID
esv2748601 CNV deletion 23290073
esv2748602 CNV deletion 23290073
esv2748603 CNV deletion 23290073
esv990813 CNV deletion 20482838
nsv826922 CNV gain 20364138
nsv832771 CNV loss 17160897

Variation tolerance for SFTA3 Gene

Residual Variation Intolerance Score: 68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.75; 33.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SFTA3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SFTA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFTA3 Gene

Disorders for SFTA3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SFTA3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
pulmonary surfactant metabolism dysfunction
  • pulmonary alveolar proteinosis
- elite association - COSMIC cancer census association via MalaCards
Search SFTA3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SFTA3

Genetic Association Database (GAD)
SFTA3
Human Genome Epidemiology (HuGE) Navigator
SFTA3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SFTA3
genes like me logo Genes that share disorders with SFTA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SFTA3 Gene

Publications for SFTA3 Gene

  1. SFTA3, a novel protein of the lung: three-dimensional structure, characterisation and immune activation. (PMID: 24743970) Schicht M. … Brauer L. (Eur. Respir. J. 2014) 3 4 65
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65
  3. Long noncoding RNAs are spatially correlated with transcription factors and regulate lung development. (PMID: 24939938) Herriges M.J. … Morrisey E.E. (Genes Dev. 2014) 3 65
  4. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 65

Products for SFTA3 Gene

Sources for SFTA3 Gene

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