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Aliases for SFTA3 Gene

Aliases for SFTA3 Gene

  • Surfactant Associated 3 2 3
  • Surfactant Associated Protein H 2 3
  • Surfactant-Associated Protein H 3 4
  • SFTPH 3 4
  • SP-H 3 4
  • Surfactant-Associated Protein 3 3
  • Putative Protein SFTA3 3
  • NANCI 3

External Ids for SFTA3 Gene

Previous HGNC Symbols for SFTA3 Gene

  • SFTPH

Previous GeneCards Identifiers for SFTA3 Gene

  • GC14M036014
  • GC14M036942
  • GC14M017057

Summaries for SFTA3 Gene

GeneCards Summary for SFTA3 Gene

SFTA3 (Surfactant Associated 3) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFTA3 Gene

Genomics for SFTA3 Gene

Regulatory Elements for SFTA3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SFTA3 Gene

Start:
36,473,288 bp from pter
End:
36,513,829 bp from pter
Size:
40,542 bases
Orientation:
Minus strand

Genomic View for SFTA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SFTA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFTA3 Gene

Proteins for SFTA3 Gene

  • Protein details for SFTA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C7M3-SFTA3_HUMAN
    Recommended name:
    Surfactant-associated protein 3
    Protein Accession:
    P0C7M3
    Secondary Accessions:

    Protein attributes for SFTA3 Gene

    Size:
    94 amino acids
    Molecular mass:
    10526 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SFTA3 Gene

Proteomics data for SFTA3 Gene at MOPED

Post-translational modifications for SFTA3 Gene

No Post-translational modifications

Other Protein References for SFTA3 Gene

No data available for DME Specific Peptides for SFTA3 Gene

Domains for SFTA3 Gene

Protein Domains for SFTA3 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for SFTA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SFTA3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SFTA3 Gene

Function for SFTA3 Gene

Molecular function for SFTA3 Gene

UniProtKB/Swiss-Prot Induction: By lipopolysaccharides (LPS). Down-regulated by cytokines IL1B and IL23.

Phenotypes for SFTA3 Gene

GenomeRNAi human phenotypes for SFTA3:
genes like me logo Genes that share phenotypes with SFTA3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SFTA3 Gene

Localization for SFTA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFTA3 Gene

Cytoplasm. Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SFTA3 Gene COMPARTMENTS Subcellular localization image for SFTA3 gene
Compartment Confidence
cytosol 2
extracellular 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SFTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SFTA3: view

Pathways for SFTA3 Gene

SuperPathways for SFTA3 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Lung Cancer in human,mouse,rat

Interacting Proteins for SFTA3 Gene

Gene Ontology (GO) - Biological Process for SFTA3 Gene

None

No data available for Pathways by source for SFTA3 Gene

Transcripts for SFTA3 Gene

Unigene Clusters for SFTA3 Gene

Surfactant associated 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SFTA3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SFTA3
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SFTA3 Gene

No ASD Table

Relevant External Links for SFTA3 Gene

GeneLoc Exon Structure for
SFTA3
ECgene alternative splicing isoforms for
SFTA3

Expression for SFTA3 Gene

mRNA expression in normal human tissues for SFTA3 Gene

mRNA differential expression in normal tissues according to GTEx for SFTA3 Gene

This gene is overexpressed in Thyroid (28.2) and Lung (21.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SFTA3 Gene

SOURCE GeneReport for Unigene cluster for SFTA3 Gene Hs.509165

mRNA Expression by UniProt/SwissProt for SFTA3 Gene

P0C7M3-SFTA3_HUMAN
Tissue specificity: Found (at protein level) in lung alveolar cells type I and II, as well as alveolar macrophages.
genes like me logo Genes that share expressions with SFTA3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SFTA3 Gene

Orthologs for SFTA3 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SFTA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SFTA3 35
  • 98.58 (n)
  • 96.81 (a)
SFTA3 36
  • 89 (a)
OneToOne
Species with no ortholog for SFTA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SFTA3 Gene

ENSEMBL:
Gene Tree for SFTA3 (if available)
TreeFam:
Gene Tree for SFTA3 (if available)

Paralogs for SFTA3 Gene

No data available for Paralogs for SFTA3 Gene

Variants for SFTA3 Gene

Sequence variations from dbSNP and Humsavar for SFTA3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs735599 -- 36,508,866(-) TTTAA(A/G)GGAAC intron-variant
rs735708 -- 36,509,462(-) CTGGG(A/T)GGTGG intron-variant
rs761999 -- 36,478,252(-) GAATA(A/C)AAAAG intron-variant
rs927285 -- 36,478,763(-) CTCCT(C/T)GTAGC intron-variant
rs927286 -- 36,478,551(-) GATAC(C/G)TTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SFTA3 Gene

Variant ID Type Subtype PubMed ID
nsv832771 CNV Loss 17160897
nsv826922 CNV Gain 20364138
esv2748601 CNV Deletion 23290073
esv990813 CNV Deletion 20482838
esv2748602 CNV Deletion 23290073
esv2748603 CNV Deletion 23290073

Relevant External Links for SFTA3 Gene

HapMap Linkage Disequilibrium report
SFTA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFTA3 Gene

Disorders for SFTA3 Gene

Relevant External Links for SFTA3

Genetic Association Database (GAD)
SFTA3
Human Genome Epidemiology (HuGE) Navigator
SFTA3
genes like me logo Genes that share disorders with SFTA3: view

No data available for UniProtKB/Swiss-Prot for SFTA3 Gene

Publications for SFTA3 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  2. Long noncoding RNAs are spatially correlated with transcription factors and regulate lung development. (PMID: 24939938) Herriges M.J. … Morrisey E.E. (Genes Dev. 2014) 3
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. SFTA3, a novel protein of the lung: three-dimensional structure, characterisation and immune activation. (PMID: 24743970) Schicht M. … Brauer L. (Eur. Respir. J. 2014) 4

Products for SFTA3 Gene

Sources for SFTA3 Gene

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