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Aliases for SFTA2 Gene

Aliases for SFTA2 Gene

  • Surfactant Associated 2 2 3
  • Surfactant Associated Protein G 2 3
  • Surfactant-Associated Protein G 3 4
  • SFTPG 3 4
  • SP-G 3 4
  • Surfactant-Associated Protein 2 3
  • GSGL541 3
  • UNQ541 3

External Ids for SFTA2 Gene

Previous Symbols for SFTA2 Gene

  • SFTPG

Summaries for SFTA2 Gene

GeneCards Summary for SFTA2 Gene

SFTA2 (Surfactant Associated 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFTA2 Gene

Genomics for SFTA2 Gene

Genomic Location for SFTA2 Gene

Start:
30,931,350 bp from pter
End:
30,932,175 bp from pter
Size:
826 bases
Orientation:
Minus strand

Genomic View for SFTA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SFTA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for SFTA2 Gene

Proteins for SFTA2 Gene

  • Protein details for SFTA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UW10-SFTA2_HUMAN
    Recommended name:
    Surfactant-associated protein 2
    Protein Accession:
    Q6UW10
    Secondary Accessions:
    • A2ABK7
    • A2ACH1
    • B7ZCJ7

    Protein attributes for SFTA2 Gene

    Size:
    78 amino acids
    Molecular mass:
    8396 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SFTA2 Gene

Proteomics data for SFTA2 Gene at MOPED

Post-translational modifications for SFTA2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn37

Other Protein References for SFTA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SFTA2 Gene

Domains for SFTA2 Gene

Protein Domains for SFTA2 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with SFTA2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SFTA2 Gene

Function for SFTA2 Gene

Phenotypes for SFTA2 Gene

GenomeRNAi human phenotypes for SFTA2:
genes like me logo Genes that share phenotypes with SFTA2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SFTA2 Gene

Localization for SFTA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFTA2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SFTA2 Gene COMPARTMENTS Subcellular localization image for SFTA2 gene
Compartment Confidence
extracellular 4

Gene Ontology (GO) - Cellular Components for SFTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SFTA2: view

Pathways for SFTA2 Gene

SuperPathways for SFTA2 Gene

No Data Available

Interacting Proteins for SFTA2 Gene

Gene Ontology (GO) - Biological Process for SFTA2 Gene

None

No data available for Pathways by source for SFTA2 Gene

Transcripts for SFTA2 Gene

mRNA/cDNA for SFTA2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SFTA2 Gene

Surfactant associated 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SFTA2 Gene

No ASD Table

Relevant External Links for SFTA2 Gene

GeneLoc Exon Structure for
SFTA2
ECgene alternative splicing isoforms for
SFTA2

Expression for SFTA2 Gene

mRNA expression in normal human tissues for SFTA2 Gene

mRNA differential expression in normal tissues according to GTEx for SFTA2 Gene

This gene is overexpressed in Lung (35.3) and Esophagus - Mucosa (9.2).

SOURCE GeneReport for Unigene cluster for SFTA2 Gene Hs.211267

genes like me logo Genes that share expressions with SFTA2: view

Orthologs for SFTA2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SFTA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SFTA2 36
  • 99.57 (n)
  • 98.72 (a)
SFTA2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SFTA2 37
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sfta2 16
Sfta2 37
  • 55 (a)
OneToOne
Species with no ortholog for SFTA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SFTA2 Gene

ENSEMBL:
Gene Tree for SFTA2 (if available)
TreeFam:
Gene Tree for SFTA2 (if available)

Paralogs for SFTA2 Gene

No data available for Paralogs for SFTA2 Gene

Variants for SFTA2 Gene

Sequence variations from dbSNP and Humsavar for SFTA2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2253588 -- 30,931,600(-) TACAT(C/G)GCGCC intron-variant
rs2253705 -- 30,932,317(-) TGGAA(A/G)AGAGG upstream-variant-2KB
rs2253718 -- 30,932,650(-) CTTCT(A/C)CTCTT upstream-variant-2KB
rs2286654 -- 30,932,457(-) GGCCC(A/G)GGCAT upstream-variant-2KB
rs2286655 -- 30,931,969(-) TGGGA(C/T)TTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SFTA2 Gene

Variant ID Type Subtype PubMed ID
esv2731791 CNV Deletion 23290073
esv2670269 CNV Deletion 23128226
nsv525438 CNV Gain 19592680

Relevant External Links for SFTA2 Gene

HapMap Linkage Disequilibrium report
SFTA2

Disorders for SFTA2 Gene

Relevant External Links for SFTA2

Genetic Association Database (GAD)
SFTA2
Human Genome Epidemiology (HuGE) Navigator
SFTA2
genes like me logo Genes that share disorders with SFTA2: view

No data available for UniProtKB/Swiss-Prot for SFTA2 Gene

Publications for SFTA2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 49
  5. SFTA2--a novel secretory peptide highly expressed in the lung--is modulated by lipopolysaccharide but not hyperoxia. (PMID: 22768197) Mittal R.A. … Holzinger A. (PLoS ONE 2012) 3

Products for SFTA2 Gene

Sources for SFTA2 Gene

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