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Aliases for SFTA2 Gene

Aliases for SFTA2 Gene

  • Surfactant Associated 2 2 3 5
  • Surfactant Associated Protein G 2 3
  • Surfactant-Associated Protein G 3 4
  • SFTPG 3 4
  • SP-G 3 4
  • GSGL541 3
  • UNQ541 3

External Ids for SFTA2 Gene

Previous HGNC Symbols for SFTA2 Gene


Previous GeneCards Identifiers for SFTA2 Gene

  • GC06M031010
  • GC06M030700

Summaries for SFTA2 Gene

GeneCards Summary for SFTA2 Gene

SFTA2 (Surfactant Associated 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFTA2 Gene

Genomics for SFTA2 Gene

Regulatory Elements for SFTA2 Gene

Enhancers for SFTA2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SFTA2 on UCSC Golden Path with GeneCards custom track

Promoters for SFTA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SFTA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SFTA2 Gene

30,931,350 bp from pter
30,955,636 bp from pter
24,287 bases
Minus strand

Genomic View for SFTA2 Gene

Genes around SFTA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFTA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFTA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for SFTA2 Gene

  • Protein details for SFTA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Surfactant-associated protein 2
    Protein Accession:
    Secondary Accessions:
    • A2ABK7
    • A2ACH1
    • B7ZCJ7

    Protein attributes for SFTA2 Gene

    78 amino acids
    Molecular mass:
    8396 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SFTA2 Gene

Proteomics data for SFTA2 Gene at MOPED

Post-translational modifications for SFTA2 Gene

  • Glycosylation at Asn 37
  • Modification sites at PhosphoSitePlus

Other Protein References for SFTA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SFTA2 Gene

Domains & Families for SFTA2 Gene

Protein Domains for SFTA2 Gene


Suggested Antigen Peptide Sequences for SFTA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SFTA2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SFTA2 Gene

Function for SFTA2 Gene

genes like me logo Genes that share phenotypes with SFTA2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SFTA2

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SFTA2 Gene

Localization for SFTA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFTA2 Gene


Subcellular locations from

Jensen Localization Image for SFTA2 Gene COMPARTMENTS Subcellular localization image for SFTA2 gene
Compartment Confidence
extracellular 3

No data available for Gene Ontology (GO) - Cellular Components for SFTA2 Gene

Pathways & Interactions for SFTA2 Gene

SuperPathways for SFTA2 Gene

No Data Available

Interacting Proteins for SFTA2 Gene

Gene Ontology (GO) - Biological Process for SFTA2 Gene


No data available for Pathways by source and SIGNOR curated interactions for SFTA2 Gene

Drugs & Compounds for SFTA2 Gene

No Compound Related Data Available

Transcripts for SFTA2 Gene

mRNA/cDNA for SFTA2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SFTA2 Gene

Surfactant associated 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SFTA2 Gene

No ASD Table

Relevant External Links for SFTA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SFTA2 Gene

mRNA expression in normal human tissues for SFTA2 Gene

mRNA differential expression in normal tissues according to GTEx for SFTA2 Gene

This gene is overexpressed in Lung (x35.3) and Esophagus - Mucosa (x9.2).

SOURCE GeneReport for Unigene cluster for SFTA2 Gene Hs.211267

genes like me logo Genes that share expression patterns with SFTA2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SFTA2 Gene

Orthologs for SFTA2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SFTA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SFTA2 35
  • 99.57 (n)
  • 98.72 (a)
SFTA2 36
  • 99 (a)
(Bos Taurus)
Mammalia SFTA2 36
  • 73 (a)
(Mus musculus)
Mammalia Sfta2 36
  • 55 (a)
Species with no ortholog for SFTA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SFTA2 Gene

Gene Tree for SFTA2 (if available)
Gene Tree for SFTA2 (if available)

Paralogs for SFTA2 Gene

No data available for Paralogs for SFTA2 Gene

Variants for SFTA2 Gene

Sequence variations from dbSNP and Humsavar for SFTA2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs3131787 - 30,931,747(-) GACAA(A/G)TTCCT reference, missense
rs6923002 -- 30,932,405(+) GGAAG(C/T)GGGGA upstream-variant-2KB
rs2253588 -- 30,931,600(-) TACAT(C/G/T)GCGCC intron-variant
rs2253705 -- 30,932,317(-) TGGAA(A/G)AGAGG upstream-variant-2KB
rs2253718 -- 30,932,650(-) CTTCT(A/C)CTCTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SFTA2 Gene

Variant ID Type Subtype PubMed ID
esv2731791 CNV Deletion 23290073
esv2670269 CNV Deletion 23128226
nsv525438 CNV Gain 19592680

Variation tolerance for SFTA2 Gene

Residual Variation Intolerance Score: 50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.65; 56.83% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SFTA2 Gene

Disorders for SFTA2 Gene

Relevant External Links for SFTA2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SFTA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SFTA2 Gene

Publications for SFTA2 Gene

  1. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 48 67
  2. SFTA2--a novel secretory peptide highly expressed in the lung--is modulated by lipopolysaccharide but not hyperoxia. (PMID: 22768197) Mittal R.A. … Holzinger A. (PLoS ONE 2012) 3
  3. "SP-G", a putative new surfactant protein--tissue localization and 3D structure. (PMID: 23094088) Rausch F. … Brandt W. (PLoS ONE 2012) 3
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for SFTA2 Gene

Sources for SFTA2 Gene