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Aliases for SFTA2 Gene

Aliases for SFTA2 Gene

  • Surfactant Associated 2 2 3 5
  • Surfactant Associated Protein G 2 3
  • Surfactant-Associated Protein G 3 4
  • SFTPG 3 4
  • SP-G 3 4
  • Surfactant-Associated Protein 2 3
  • GSGL541 3
  • UNQ541 3

External Ids for SFTA2 Gene

Previous HGNC Symbols for SFTA2 Gene

  • SFTPG

Previous GeneCards Identifiers for SFTA2 Gene

  • GC06M031010
  • GC06M030700

Summaries for SFTA2 Gene

GeneCards Summary for SFTA2 Gene

SFTA2 (Surfactant Associated 2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SFTA2 Gene

  • Putative surfactant protein.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFTA2 Gene

Genomics for SFTA2 Gene

Regulatory Elements for SFTA2 Gene

Enhancers for SFTA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SFTA2 on UCSC Golden Path with GeneCards custom track

Promoters for SFTA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SFTA2 Gene

Chromosome:
6
Start:
30,931,350 bp from pter
End:
30,955,636 bp from pter
Size:
24,287 bases
Orientation:
Minus strand

Genomic View for SFTA2 Gene

Genes around SFTA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFTA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFTA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for SFTA2 Gene

  • Protein details for SFTA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UW10-SFTA2_HUMAN
    Recommended name:
    Surfactant-associated protein 2
    Protein Accession:
    Q6UW10
    Secondary Accessions:
    • A2ABK7
    • A2ACH1
    • B7ZCJ7

    Protein attributes for SFTA2 Gene

    Size:
    78 amino acids
    Molecular mass:
    8396 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SFTA2 Gene

Post-translational modifications for SFTA2 Gene

Other Protein References for SFTA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SFTA2 Gene

Domains & Families for SFTA2 Gene

Protein Domains for SFTA2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SFTA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SFTA2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SFTA2 Gene

Function for SFTA2 Gene

Molecular function for SFTA2 Gene

UniProtKB/Swiss-Prot Function:
Putative surfactant protein.
genes like me logo Genes that share phenotypes with SFTA2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SFTA2

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SFTA2 Gene

Localization for SFTA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFTA2 Gene

Secreted. Cytoplasmic vesicle, secretory vesicle. Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SFTA2 Gene COMPARTMENTS Subcellular localization image for SFTA2 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for SFTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005794 Golgi apparatus IEA --
GO:0030133 transport vesicle IEA --
genes like me logo Genes that share ontologies with SFTA2: view

Pathways & Interactions for SFTA2 Gene

SuperPathways for SFTA2 Gene

No Data Available

Interacting Proteins for SFTA2 Gene

Gene Ontology (GO) - Biological Process for SFTA2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SFTA2 Gene

Drugs & Compounds for SFTA2 Gene

No Compound Related Data Available

Transcripts for SFTA2 Gene

mRNA/cDNA for SFTA2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SFTA2 Gene

Surfactant associated 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SFTA2 Gene

No ASD Table

Relevant External Links for SFTA2 Gene

GeneLoc Exon Structure for
SFTA2
ECgene alternative splicing isoforms for
SFTA2

Expression for SFTA2 Gene

mRNA expression in normal human tissues for SFTA2 Gene

mRNA differential expression in normal tissues according to GTEx for SFTA2 Gene

This gene is overexpressed in Lung (x35.3) and Esophagus - Mucosa (x9.2).

NURSA nuclear receptor signaling pathways regulating expression of SFTA2 Gene:

SFTA2

SOURCE GeneReport for Unigene cluster for SFTA2 Gene:

Hs.211267

mRNA Expression by UniProt/SwissProt for SFTA2 Gene:

Q6UW10-SFTA2_HUMAN
Tissue specificity: Predominantly expressed in lung, where it is detected in type II pneumocytes in the alveolus, and in nonciliated epithelium in bronchioli (at protein level). Also detected at lower levels in cervix, esophagus, stomach, testis and kidney.
genes like me logo Genes that share expression patterns with SFTA2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SFTA2 Gene

Orthologs for SFTA2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SFTA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SFTA2 34
  • 99.57 (n)
  • 98.72 (a)
SFTA2 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SFTA2 35
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sfta2 35
  • 55 (a)
OneToOne
Species where no ortholog for SFTA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SFTA2 Gene

ENSEMBL:
Gene Tree for SFTA2 (if available)
TreeFam:
Gene Tree for SFTA2 (if available)

Paralogs for SFTA2 Gene

No data available for Paralogs for SFTA2 Gene

Variants for SFTA2 Gene

Sequence variations from dbSNP and Humsavar for SFTA2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs3131787 - 30,931,747(-) GACAA(A/G)TTCCT reference, missense
rs4713402 -- 30,931,456(+) AAGCC(C/T)GGGCC utr-variant-3-prime
rs6923002 -- 30,932,405(+) GGAAG(C/T)GGGGA upstream-variant-2KB
rs7746905 -- 30,933,451(+) tccct(C/T)cctcc upstream-variant-2KB
rs2253588 -- 30,931,600(-) TACAT(C/G/T)GCGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SFTA2 Gene

Variant ID Type Subtype PubMed ID
esv2670269 CNV deletion 23128226
esv2731791 CNV deletion 23290073
esv3411275 CNV duplication 20981092
esv3608518 CNV gain 21293372
nsv1031677 CNV gain 25217958
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv525438 CNV gain 19592680
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781

Variation tolerance for SFTA2 Gene

Residual Variation Intolerance Score: 50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.65; 56.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SFTA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SFTA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFTA2 Gene

Disorders for SFTA2 Gene

Relevant External Links for SFTA2

Genetic Association Database (GAD)
SFTA2
Human Genome Epidemiology (HuGE) Navigator
SFTA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SFTA2

No disorders were found for SFTA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SFTA2 Gene

Publications for SFTA2 Gene

  1. SFTA2--a novel secretory peptide highly expressed in the lung--is modulated by lipopolysaccharide but not hyperoxia. (PMID: 22768197) Mittal R.A. … Holzinger A. (PLoS ONE 2012) 3 4 65
  2. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 46 65
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 65

Products for SFTA2 Gene

Sources for SFTA2 Gene

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