SFTA2 Gene
protein-coding GIFtS: 36
GCID: GC06M030899
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surfactant associated 2(Previous name: surfactant associated protein G )
(Previous symbol: SFTPG)
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Aliases
for SFTA2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Surfactant Associated 21 2 | | GSGL5412 | | SFTPG1 2 3 | | UNQ5412 | | Surfactant Associated Protein G1 2 | | Surfactant-Associated Protein 22 | | Surfactant-Associated Protein G2 3 | | |
Export aliases for SFTA2 gene to outside databasesPrevious GC identifers: GC06M031010 GC06M030700 |
Summaries
for SFTA2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SFTA2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167245.1 NT_167246.1 NT_167247.1 NT_167248.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SFTA2 gene promoter:
Max1 Spz1 ATF-2 LUN-1 LCR-F1 E47 MZF-1 CRE-BP1 NRF-2 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for SFTA2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SFTA2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.33 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.3SFTA2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M030899: view genomic region
(about GC identifiers)
Start:
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30,899,127 bp from pter |
End:
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30,899,952 bp from pter |
Size:
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826 bases |
Orientation:
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minus strand |
5 alternative locations:
| Chr6-,ALT_REF_LOCI_4 30,866,867-30,867,692 | Chr6-,ALT_REF_LOCI_2 30,888,849-30,928,859 | Chr6-,ALT_REF_LOCI_3 30,889,843-30,901,703 | | Chr6-,ALT_REF_LOCI_5 30,892,489-30,893,314 | Chr6-,ALT_REF_LOCI_6 30,888,704-30,925,107 |
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Proteins
for SFTA2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SFTA2_HUMAN, Q6UW10 (See
protein sequence)Recommended Name: Surfactant-associated protein 2 precursor Size: 78 amino acids; 8396 Da
Subcellular location: Secreted (Probable)
Secondary accessions: A2ABK7 A2ACH1 B7ZCJ7Explore the universe of human proteins at neXtProt for SFTA2: NX_Q6UW10
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6UW10
SFTA2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_995326.1
ENSEMBL proteins: ENSP00000351989
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
SFTA2 for ontologies About GeneDecksing
SFTA2 Antibody Products:
Assay Products for SFTA2: |
Protein
Domains /
Families
for SFTA2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q6UW10 |
Function
for SFTA2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFTA2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFTA2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SFTA2 (NM_205854) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SFTA2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFTA2 |
1 GenomeRNAi human phenotype for SFTA2:
|
Pathways & Interactions
for SFTA2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SFTA2
|
Drugs & Compounds
for SFTA2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SFTA2
Search CenterWatch for drugs/clinical trials and news about SFTA2
|
Transcripts
for SFTA2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SFTA2 gene: NM_205854.2 Unigene Cluster for SFTA2: Surfactant associated 2 Hs.211267 [show with all ESTs]Unigene Representative Sequence: BI8200292 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000474914 ENST00000359086(uc003nsf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFTA2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFTA2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SFTA2 (NM_205854) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SFTA2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFTA2 |
Additional cDNA sequence: AY102070.1 AY359057.1 BC039677.1 2 DOTS entries: DT.40315977 DT.95364341 4 AceView cDNA sequences: BC039677 AY359057 NM_205854 AY102070
GeneLoc Exon Structure
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Expression
for SFTA2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SFTA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAGCCATTG
About this image
See SFTA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SFTA2
SOURCE GeneReport for Unigene cluster: Hs.211267
SABiosciences Custom PCR Arrays for SFTA2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SFTA2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SFTA2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SFTA2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SFTA2 |
Orthologs
for SFTA2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for SFTA2 gene from 1/4 species (see all 4) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Sfta25 |
surfactant associated 2 |
-- |
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17 (18.70 cM) 35601549 |
ENSEMBL Gene Tree for SFTA2 (if available)
TreeFam Gene Tree for SFTA2 (if available) |
Paralogs
for SFTA2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SFTA2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SFTA2 (30899127 - 30899952 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SFTA2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SFTA2 |
|
Disorders
/ Diseases
for SFTA2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SFTA2 for disorders About GeneDecksing
2  diseases for SFTA2: About MalaCardssystemic lupus erythematosus lupus erythematosus
Human Genome Epidemiology (HuGE) Navigator: SFTA2 (2 documents)
Export disorders for SFTA2 gene to outside databases
|
Publications
for SFTA2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SFTA2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SFTA2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- SFTA2--a novel secretory peptide highly expressed in t he lung--is modulated by lipopolysaccharide but not hyperoxia. (PubMed id 22768197)1 Mittal R.A....Holzinger A. (2012)
- High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1 Barcellos L.F....Criswell L.A. (2009)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Generation and analysis of 280,000 human expressed sequence tags. (PubMed id 8889549)1 Hillier L.D....Marra M. (1996)
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External Searches for SFTA2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SFTA2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SFTA2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SFTA2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SFTA2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SFTA2 gene:
Search GeneIP for patents involving SFTA2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SFTA2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SFTA2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SFTA2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SFTA2 | | | OriGene Protein Over-expression Lysate for SFTA2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SFTA2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFTA2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFTA2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SFTA2 | | OriGene Custom Protein Services for SFTA2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SFTA2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SFTA2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SFTA2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SFTA2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SFTA2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SFTA2 |
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 |  |  |  | |
| | | | Search Tocris compounds for SFTA2 |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for SFTA2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFTA2 |
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