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Aliases for SFTA2 Gene

Aliases for SFTA2 Gene

  • Surfactant Associated 2 2 3 5
  • Surfactant Associated Protein G 2 3
  • SFTPG 3 4
  • SP-G 3 4
  • Surfactant-Associated Protein 2 3
  • Surfactant-Associated Protein G 4
  • GSGL541 3
  • UNQ541 3

External Ids for SFTA2 Gene

Previous HGNC Symbols for SFTA2 Gene


Previous GeneCards Identifiers for SFTA2 Gene

  • GC06M031010
  • GC06M030700

Summaries for SFTA2 Gene

GeneCards Summary for SFTA2 Gene

SFTA2 (Surfactant Associated 2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SFTA2 Gene

  • Putative surfactant protein.

Additional gene information for SFTA2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFTA2 Gene

Genomics for SFTA2 Gene

GeneHancer (GH) Regulatory Elements for SFTA2 Gene

Promoters and enhancers for SFTA2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I030955 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE 550.8 -0.2 -209 0.9 PKNOX1 ATF1 POLR2B E2F8 ZNF143 ATF7 RUNX3 RXRA NCOA1 REST HCG21 SFTA2 VARS2 DDR1 DDR1-AS1 MICD GNL1 CCHCR1 NAPGP2
GH06I030931 Promoter/Enhancer 1.2 EPDnew ENCODE dbSUPER 550.3 +23.2 23182 1.2 BCOR ZFP36 ZMYM3 KDM1A ENSG00000252761 SFTA2 VARS2 CCHCR1
GH06I030879 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.6 +71.3 71253 9.2 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 SLC30A9 ZNF766 ZNF143 FOS DDR1 VARS2 HLA-C PSORS1C1 GNL1 PSORS1C3 SFTA2 HCG18 IER3 FLOT1
GH06I031352 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.4 -400.6 -400556 7 HDGF PKNOX1 ATF1 SMAD1 NSD2 ZNF2 IRF4 GLIS2 ZNF207 ZNF143 HLA-B ENSG00000271581 GC06M031409 GC06M031410 PIR40863 MIR6891 HLA-C DDX39B MICA LY6G5B
GH06I030894 Enhancer 0.5 dbSUPER 22.5 +59.9 59949 3.2 POLR2A ZNF366 PHB2 YBX1 ZBTB17 VARS2 SFTA2 HLA-C ENSG00000252761 FLOT1 IER3 DPCR1 C6orf15 PSORS1C1 HCG21
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SFTA2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SFTA2 gene promoter:

Genomic Locations for SFTA2 Gene

Genomic Locations for SFTA2 Gene
24,287 bases
Minus strand

Genomic View for SFTA2 Gene

Genes around SFTA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFTA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFTA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for SFTA2 Gene

  • Protein details for SFTA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Surfactant-associated protein 2
    Protein Accession:
    Secondary Accessions:
    • A2ABK7
    • A2ACH1
    • B7ZCJ7

    Protein attributes for SFTA2 Gene

    78 amino acids
    Molecular mass:
    8396 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SFTA2 Gene

Post-translational modifications for SFTA2 Gene

Other Protein References for SFTA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SFTA2 Gene

Domains & Families for SFTA2 Gene

Gene Families for SFTA2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for SFTA2 Gene


Suggested Antigen Peptide Sequences for SFTA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SFTA2: view

No data available for UniProtKB/Swiss-Prot for SFTA2 Gene

Function for SFTA2 Gene

Molecular function for SFTA2 Gene

UniProtKB/Swiss-Prot Function:
Putative surfactant protein.

Phenotypes From GWAS Catalog for SFTA2 Gene

genes like me logo Genes that share phenotypes with SFTA2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SFTA2 Gene

Localization for SFTA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFTA2 Gene

Secreted. Cytoplasmic vesicle, secretory vesicle. Golgi apparatus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SFTA2 gene
Compartment Confidence
extracellular 5
golgi apparatus 3

Gene Ontology (GO) - Cellular Components for SFTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005794 Golgi apparatus IEA --
GO:0030133 transport vesicle IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with SFTA2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SFTA2 Gene

Pathways & Interactions for SFTA2 Gene

SuperPathways for SFTA2 Gene

No Data Available

Interacting Proteins for SFTA2 Gene

Gene Ontology (GO) - Biological Process for SFTA2 Gene


No data available for Pathways by source and SIGNOR curated interactions for SFTA2 Gene

Drugs & Compounds for SFTA2 Gene

No Compound Related Data Available

Transcripts for SFTA2 Gene

mRNA/cDNA for SFTA2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SFTA2 Gene

Surfactant associated 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SFTA2 Gene

No ASD Table

Relevant External Links for SFTA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SFTA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SFTA2 Gene

mRNA differential expression in normal tissues according to GTEx for SFTA2 Gene

This gene is overexpressed in Lung (x35.3) and Esophagus - Mucosa (x9.2).

NURSA nuclear receptor signaling pathways regulating expression of SFTA2 Gene:


SOURCE GeneReport for Unigene cluster for SFTA2 Gene:


mRNA Expression by UniProt/SwissProt for SFTA2 Gene:

Tissue specificity: Predominantly expressed in lung, where it is detected in type II pneumocytes in the alveolus, and in nonciliated epithelium in bronchioli (at protein level). Also detected at lower levels in cervix, esophagus, stomach, testis and kidney.

Evidence on tissue expression from TISSUES for SFTA2 Gene

  • Intestine(4)
genes like me logo Genes that share expression patterns with SFTA2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SFTA2 Gene

Orthologs for SFTA2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SFTA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SFTA2 33 34
  • 99.57 (n)
(Bos Taurus)
Mammalia SFTA2 34
  • 73 (a)
(Mus musculus)
Mammalia Sfta2 34
  • 55 (a)
Species where no ortholog for SFTA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SFTA2 Gene

Gene Tree for SFTA2 (if available)
Gene Tree for SFTA2 (if available)

Paralogs for SFTA2 Gene

No data available for Paralogs for SFTA2 Gene

Variants for SFTA2 Gene

Sequence variations from dbSNP and Humsavar for SFTA2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000665033 -- 30,933,148(-) C/T upstream_transcript_variant
rs1000715536 -- 30,933,426(-) G/T upstream_transcript_variant
rs1002854370 -- 30,932,255(-) G/C upstream_transcript_variant
rs1003054175 -- 30,933,936(-) T/C upstream_transcript_variant
rs1003653046 -- 30,931,024(-) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SFTA2 Gene

Variant ID Type Subtype PubMed ID
esv2670269 CNV deletion 23128226
esv2731791 CNV deletion 23290073
esv3411275 CNV duplication 20981092
esv3608518 CNV gain 21293372
nsv1031677 CNV gain 25217958
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv525438 CNV gain 19592680
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781

Variation tolerance for SFTA2 Gene

Residual Variation Intolerance Score: 50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.65; 56.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SFTA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFTA2 Gene

Disorders for SFTA2 Gene

Additional Disease Information for SFTA2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SFTA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SFTA2 Gene

Publications for SFTA2 Gene

  1. SFTA2--a novel secretory peptide highly expressed in the lung--is modulated by lipopolysaccharide but not hyperoxia. (PMID: 22768197) Mittal RA … Holzinger A (PloS one 2012) 3 4 58
  2. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 44 58
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for SFTA2 Gene

Sources for SFTA2 Gene

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