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Aliases for SFT2D3 Gene

Aliases for SFT2D3 Gene

  • SFT2 Domain Containing 3 2 3 5
  • SFT2 Domain-Containing Protein 3 4

External Ids for SFT2D3 Gene

Previous GeneCards Identifiers for SFT2D3 Gene

  • GC02P128175
  • GC02P128458
  • GC02P120764

Summaries for SFT2D3 Gene

GeneCards Summary for SFT2D3 Gene

SFT2D3 (SFT2 Domain Containing 3) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SFT2D3 Gene

  • May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFT2D3 Gene

Genomics for SFT2D3 Gene

Regulatory Elements for SFT2D3 Gene

Enhancers for SFT2D3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SFT2D3 on UCSC Golden Path with GeneCards custom track

Promoters for SFT2D3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SFT2D3 Gene

Chromosome:
2
Start:
127,701,023 bp from pter
End:
127,705,242 bp from pter
Size:
4,220 bases
Orientation:
Plus strand

Genomic View for SFT2D3 Gene

Genes around SFT2D3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFT2D3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFT2D3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFT2D3 Gene

Proteins for SFT2D3 Gene

  • Protein details for SFT2D3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q587I9-SFT2C_HUMAN
    Recommended name:
    Vesicle transport protein SFT2C
    Protein Accession:
    Q587I9
    Secondary Accessions:
    • Q8N2P9

    Protein attributes for SFT2D3 Gene

    Size:
    215 amino acids
    Molecular mass:
    21790 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SFT2D3 Gene

Post-translational modifications for SFT2D3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SFT2D3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for SFT2C

No data available for DME Specific Peptides for SFT2D3 Gene

Domains & Families for SFT2D3 Gene

Protein Domains for SFT2D3 Gene

Suggested Antigen Peptide Sequences for SFT2D3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q587I9

UniProtKB/Swiss-Prot:

SFT2C_HUMAN :
  • Belongs to the SFT2 family.
Family:
  • Belongs to the SFT2 family.
genes like me logo Genes that share domains with SFT2D3: view

No data available for Gene Families for SFT2D3 Gene

Function for SFT2D3 Gene

Molecular function for SFT2D3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.

Phenotypes for SFT2D3 Gene

GenomeRNAi human phenotypes for SFT2D3:
genes like me logo Genes that share phenotypes with SFT2D3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SFT2D3 Gene

Localization for SFT2D3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFT2D3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SFT2D3 Gene COMPARTMENTS Subcellular localization image for SFT2D3 gene
Compartment Confidence
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for SFT2D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SFT2D3: view

Pathways & Interactions for SFT2D3 Gene

SuperPathways for SFT2D3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SFT2D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA,IBA --
genes like me logo Genes that share ontologies with SFT2D3: view

No data available for Pathways by source and SIGNOR curated interactions for SFT2D3 Gene

Drugs & Compounds for SFT2D3 Gene

No Compound Related Data Available

Transcripts for SFT2D3 Gene

mRNA/cDNA for SFT2D3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(298) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SFT2D3 Gene

SFT2 domain containing 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SFT2D3 Gene

No ASD Table

Relevant External Links for SFT2D3 Gene

GeneLoc Exon Structure for
SFT2D3
ECgene alternative splicing isoforms for
SFT2D3

Expression for SFT2D3 Gene

mRNA expression in normal human tissues for SFT2D3 Gene

Protein differential expression in normal tissues from HIPED for SFT2D3 Gene

This gene is overexpressed in Bone (32.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SFT2D3 Gene



Protein tissue co-expression partners for SFT2D3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SFT2D3 Gene:

SFT2D3

SOURCE GeneReport for Unigene cluster for SFT2D3 Gene:

Hs.345849
genes like me logo Genes that share expression patterns with SFT2D3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SFT2D3 Gene

Orthologs for SFT2D3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SFT2D3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SFT2D3 34
  • 81.22 (n)
  • 81.22 (a)
SFT2D3 35
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sft2d3 34
  • 79.4 (n)
  • 78.77 (a)
Sft2d3 16
Sft2d3 35
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SFT2D3 34
  • 98.91 (n)
  • 98.6 (a)
SFT2D3 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sft2d3 34
  • 78.6 (n)
  • 80.47 (a)
oppossum
(Monodelphis domestica)
Mammalia SFT2D3 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8266 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.29830 34
zebrafish
(Danio rerio)
Actinopterygii sft2d3 34
  • 56.96 (n)
  • 52.53 (a)
sft2d3 35
  • 42 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009524 34
  • 47.94 (n)
  • 34.57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33635 34
  • 46.39 (n)
  • 44.06 (a)
CG33635 35
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C18E9.10 34
  • 43.2 (n)
  • 41.84 (a)
C18E9.10 35
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SFT2 35
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
OneToOne
Species where no ortholog for SFT2D3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SFT2D3 Gene

ENSEMBL:
Gene Tree for SFT2D3 (if available)
TreeFam:
Gene Tree for SFT2D3 (if available)

Paralogs for SFT2D3 Gene

No data available for Paralogs for SFT2D3 Gene

Variants for SFT2D3 Gene

Sequence variations from dbSNP and Humsavar for SFT2D3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10206957 - 127,701,640(+) GGGAC(C/G)GGCCG reference, missense
rs1048211 -- 127,701,465(+) ACCGA(A/G)CCGCT utr-variant-5-prime
rs7580688 -- 127,700,367(+) AGAAT(A/G)TATTT upstream-variant-2KB
rs6713423 -- 127,701,384(+) CGCAG(A/G)GCAGG utr-variant-5-prime
rs800859 -- 127,703,382(+) TGAAA(A/G)TAATG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SFT2D3 Gene

Variant ID Type Subtype PubMed ID
dgv4069n100 CNV gain 25217958
nsv1122007 CNV deletion 24896259
nsv1143959 CNV deletion 24896259
nsv470482 CNV loss 18288195
nsv583038 CNV loss 21841781

Variation tolerance for SFT2D3 Gene

Gene Damage Index Score: 9.47; 88.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SFT2D3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SFT2D3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFT2D3 Gene

Disorders for SFT2D3 Gene

Relevant External Links for SFT2D3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SFT2D3

No disorders were found for SFT2D3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SFT2D3 Gene

Publications for SFT2D3 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 65
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 65
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 65
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3 65

Products for SFT2D3 Gene

Sources for SFT2D3 Gene

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