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Aliases for SFT2D3 Gene

Aliases for SFT2D3 Gene

  • SFT2 Domain Containing 3 2 3 5
  • SFT2 Domain-Containing Protein 3 4

External Ids for SFT2D3 Gene

Previous GeneCards Identifiers for SFT2D3 Gene

  • GC02P128175
  • GC02P128458
  • GC02P120764

Summaries for SFT2D3 Gene

GeneCards Summary for SFT2D3 Gene

SFT2D3 (SFT2 Domain Containing 3) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SFT2D3 Gene

  • May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFT2D3 Gene

Genomics for SFT2D3 Gene

Regulatory Elements for SFT2D3 Gene

Enhancers for SFT2D3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SFT2D3 on UCSC Golden Path with GeneCards custom track

Promoters for SFT2D3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SFT2D3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SFT2D3 Gene

127,701,023 bp from pter
127,705,242 bp from pter
4,220 bases
Plus strand

Genomic View for SFT2D3 Gene

Genes around SFT2D3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFT2D3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFT2D3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFT2D3 Gene

Proteins for SFT2D3 Gene

  • Protein details for SFT2D3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vesicle transport protein SFT2C
    Protein Accession:
    Secondary Accessions:
    • Q8N2P9

    Protein attributes for SFT2D3 Gene

    215 amino acids
    Molecular mass:
    21790 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SFT2D3 Gene

Proteomics data for SFT2D3 Gene at MOPED

Post-translational modifications for SFT2D3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SFT2D3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for SFT2C
  • Santa Cruz Biotechnology (SCBT) Antibodies for SFT2D3

No data available for DME Specific Peptides for SFT2D3 Gene

Domains & Families for SFT2D3 Gene

Protein Domains for SFT2D3 Gene

Suggested Antigen Peptide Sequences for SFT2D3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SFT2 family.
  • Belongs to the SFT2 family.
genes like me logo Genes that share domains with SFT2D3: view

No data available for Gene Families for SFT2D3 Gene

Function for SFT2D3 Gene

Molecular function for SFT2D3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.

Phenotypes for SFT2D3 Gene

GenomeRNAi human phenotypes for SFT2D3:
genes like me logo Genes that share phenotypes with SFT2D3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SFT2D3 Gene

Localization for SFT2D3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFT2D3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SFT2D3 Gene COMPARTMENTS Subcellular localization image for SFT2D3 gene
Compartment Confidence
plasma membrane 3
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SFT2D3 Gene

Pathways & Interactions for SFT2D3 Gene

SuperPathways for SFT2D3 Gene

No Data Available

Interacting Proteins for SFT2D3 Gene

Gene Ontology (GO) - Biological Process for SFT2D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with SFT2D3: view

No data available for Pathways by source and SIGNOR curated interactions for SFT2D3 Gene

Drugs & Compounds for SFT2D3 Gene

No Compound Related Data Available

Transcripts for SFT2D3 Gene

mRNA/cDNA for SFT2D3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(298) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SFT2D3 Gene

SFT2 domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SFT2D3 Gene

No ASD Table

Relevant External Links for SFT2D3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SFT2D3 Gene

mRNA expression in normal human tissues for SFT2D3 Gene

Protein differential expression in normal tissues from HIPED for SFT2D3 Gene

This gene is overexpressed in Bone (32.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SFT2D3 Gene

SOURCE GeneReport for Unigene cluster for SFT2D3 Gene Hs.345849

genes like me logo Genes that share expression patterns with SFT2D3: view

Protein tissue co-expression partners for SFT2D3 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SFT2D3 Gene

Orthologs for SFT2D3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SFT2D3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SFT2D3 35
  • 81.22 (n)
  • 81.22 (a)
SFT2D3 36
  • 78 (a)
(Mus musculus)
Mammalia Sft2d3 35
  • 79.4 (n)
  • 78.77 (a)
Sft2d3 16
Sft2d3 36
  • 79 (a)
(Pan troglodytes)
Mammalia SFT2D3 35
  • 98.91 (n)
  • 98.6 (a)
SFT2D3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Sft2d3 35
  • 78.6 (n)
  • 80.47 (a)
(Monodelphis domestica)
Mammalia SFT2D3 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8266 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.29830 35
(Danio rerio)
Actinopterygii sft2d3 35
  • 56.96 (n)
  • 52.53 (a)
sft2d3 36
  • 42 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009524 35
  • 47.94 (n)
  • 34.57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33635 35
  • 46.39 (n)
  • 44.06 (a)
CG33635 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea C18E9.10 35
  • 43.2 (n)
  • 41.84 (a)
C18E9.10 36
  • 25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SFT2 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
Species with no ortholog for SFT2D3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SFT2D3 Gene

Gene Tree for SFT2D3 (if available)
Gene Tree for SFT2D3 (if available)

Paralogs for SFT2D3 Gene

No data available for Paralogs for SFT2D3 Gene

Variants for SFT2D3 Gene

Sequence variations from dbSNP and Humsavar for SFT2D3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10206957 - 127,701,640(+) GGGAC(C/G)GGCCG reference, missense
rs800859 -- 127,703,382(+) TGAAA(A/G)TAATG utr-variant-3-prime
rs1048211 -- 127,701,465(+) ACCGA(A/G)CCGCT utr-variant-5-prime
rs10174458 -- 127,701,673(+) CGGGC(C/T)TGCGC reference, synonymous-codon
rs6713423 -- 127,701,384(+) CGCAG(A/G)GCAGG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SFT2D3 Gene

Variant ID Type Subtype PubMed ID
nsv875015 CNV Loss 21882294
dgv4299n71 CNV Loss 21882294
nsv470482 CNV Loss 18288195
dgv4301n71 CNV Loss 21882294
nsv875030 CNV Loss 21882294
nsv875033 CNV Loss 21882294

Variation tolerance for SFT2D3 Gene

Gene Damage Index Score: 9.47; 88.69% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SFT2D3 Gene

Disorders for SFT2D3 Gene

Relevant External Links for SFT2D3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SFT2D3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SFT2D3 Gene

Publications for SFT2D3 Gene

  1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for SFT2D3 Gene

Sources for SFT2D3 Gene