SFT2D3 Gene
protein-coding GIFtS: 41
GCID: GC02P128458
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SFT2 domain containing 3
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Aliases
for SFT2D3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SFT2 Domain Containing 31 2 | | SFT2 Domain-Containing Protein 32 3 | | MGC53911 | | Vesicle Transport Protein SFT2C2 |
Export aliases for SFT2D3 gene to outside databasesPrevious GC identifers: GC02P128175 GC02P120764 |
Summaries
for SFT2D3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SFT2C_HUMAN, Q587I9Function: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with theGolgi complex (By similarity)
|
Genomic Views
for SFT2D3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022135.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SFT2D3 gene promoter:
AML1a MAZR Pax-5 MIF-1 Nkx5-1 POU3F2 YY1 HNF-4alpha1 CP2 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for SFT2D3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SFT2D3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q14.3 Ensembl cytogenetic band: 2q14.3 HGNC cytogenetic band: 2q14.3SFT2D3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P128458: view genomic region
(about GC identifiers)
Start:
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128,458,597 bp from pter |
End:
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128,461,407 bp from pter |
Size:
|
2,811 bases |
Orientation:
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plus strand |
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Proteins
for SFT2D3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SFT2C_HUMAN, Q587I9 (See
protein sequence)Recommended Name: Vesicle transport protein SFT2C Size: 215 amino acids; 21790 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q8N2P9Explore the universe of human proteins at neXtProt for SFT2D3: NX_Q587I9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q587I9
SFT2D3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_116129.3
ENSEMBL proteins: ENSP00000310803
Human Recombinant Protein Products for SFT2D3:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
SFT2D3 for ontologies About GeneDecksing
SFT2D3 Antibody Products:
Assay Products for SFT2D3: |
Protein
Domains /
Families
for SFT2D3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SFT2D3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q587I9ProtoNet protein and cluster: Q587I9 UniProtKB/Swiss-Prot: SFT2C_HUMAN, Q587I9Similarity: Belongs to the SFT2 family |
Function
for SFT2D3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SFT2C_HUMAN, Q587I9Function: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with theGolgi complex (By similarity)Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFT2D3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFT2D3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SFT2D3 (NM_032740) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SFT2D3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFT2D3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFT2D3 |
|
Pathways & Interactions
for SFT2D3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SFT2D3
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for SFT2D3 (ENSP000003108034) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015031 | protein transport |
IEA | -- | | GO:0016192 | vesicle-mediated transport |
IEA | -- |
SFT2D3 for ontologies About GeneDecksing
|
Drugs & Compounds
for SFT2D3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SFT2D3
Search CenterWatch for drugs/clinical trials and news about SFT2D3 / SFT2C
|
Transcripts
for SFT2D3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SFT2D3 gene: NM_032740.3 Unigene Cluster for SFT2D3: SFT2 domain containing 3 Hs.345849 [show with all ESTs]Unigene Representative Sequence: NM_0327401 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000310981(uc002tpf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFT2D3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFT2D3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SFT2D3 (NM_032740) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SFT2D3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFT2D3 |
Additional cDNA sequence: AK074549.1 BC006808.1 BC063637.1 BC110324.1 BC133675.1 5 DOTS entries: DT.114076 DT.120966434 DT.409300 DT.85105571 DT.100774516 24/298 AceView cDNA sequences (see all 298): BU552527 BQ056233 BM751741 AW504651 AA927896 BX115033 AI289429 BQ011321 BM675133 BF593522 AA491257 BF063402 AL834365 BE859089 AW968222 BU633446 AI480300 AW243049 BU538276 AI678924 Z41772 AW167162 CR591938 AW407659
GeneLoc Exon Structure
|
Expression
for SFT2D3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SFT2D3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATTTCTACA
About this image
See SFT2D3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SFT2D3
SOURCE GeneReport for Unigene cluster: Hs.345849
SABiosciences Custom PCR Arrays for SFT2D3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SFT2D3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SFT2D3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SFT2D3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SFT2D3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFT2D3 |
Orthologs
for SFT2D3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SFT2D3 gene from 7/23 species (see all 23) About this table
ENSEMBL Gene Tree for SFT2D3 (if available)
TreeFam Gene Tree for SFT2D3 (if available) |
Paralogs
for SFT2D3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SFT2D3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SFT2D3 (128458597 - 128461407 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SFT2D3
1 CNV: 30103 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SFT2D3 |
|
Disorders
/ Diseases
for SFT2D3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SFT2D3 for disorders About GeneDecksing
1  disease for SFT2D3: About MalaCardsmalaria
Export disorders for SFT2D3 gene to outside databases
|
Publications
for SFT2D3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SFT2D3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SFT2D3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for SFT2D3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SFT2D3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SFT2D3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SFT2D3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SFT2D3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SFT2D3 gene:
Search GeneIP for patents involving SFT2D3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SFT2D3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SFT2D3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SFT2D3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SFT2D3 | | | OriGene Protein Over-expression Lysate for SFT2D3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SFT2D3 | | OriGene 3'-UTR Clone for SFT2D3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFT2D3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFT2D3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SFT2D3 | | OriGene Custom Protein Services for SFT2D3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SFT2D3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SFT2D3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SFT2D3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SFT2D3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SFT2D3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SFT2D3 |
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 |  |  |  | |
| | | | Search Tocris compounds for SFT2D3 |
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 | | | SFT2D3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFT2D3 |
|  |  |  |  | | | | ThermoFisher Antibody for SFT2D3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFT2D3 |
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