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Aliases for SFT2D2 Gene

Aliases for SFT2D2 Gene

  • SFT2 Domain Containing 2 2 3
  • SFT2 Domain-Containing Protein 2 3 4
  • Vesicle Transport Protein SFT2B 3
  • DJ747L4.C1.2 3
  • UNQ512 3

External Ids for SFT2D2 Gene

Previous GeneCards Identifiers for SFT2D2 Gene

  • GC01P164927
  • GC01P166462
  • GC01P166463
  • GC01P168195
  • GC01P139439

Summaries for SFT2D2 Gene

GeneCards Summary for SFT2D2 Gene

SFT2D2 (SFT2 Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is SFT2D1.

UniProtKB/Swiss-Prot for SFT2D2 Gene

  • May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFT2D2 Gene

Genomics for SFT2D2 Gene

Regulatory Elements for SFT2D2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SFT2D2 Gene

Start:
168,225,938 bp from pter
End:
168,253,025 bp from pter
Size:
27,088 bases
Orientation:
Plus strand

Genomic View for SFT2D2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SFT2D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFT2D2 Gene

Proteins for SFT2D2 Gene

  • Protein details for SFT2D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95562-SFT2B_HUMAN
    Recommended name:
    Vesicle transport protein SFT2B
    Protein Accession:
    O95562
    Secondary Accessions:
    • A8K2R0
    • Q6UWR8

    Protein attributes for SFT2D2 Gene

    Size:
    160 amino acids
    Molecular mass:
    17779 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ89038.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SFT2D2 Gene

Proteomics data for SFT2D2 Gene at MOPED

Post-translational modifications for SFT2D2 Gene

  • Ubiquitination at Lys6
  • Modification sites at PhosphoSitePlus

Other Protein References for SFT2D2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SFT2D2 Gene

Domains for SFT2D2 Gene

Protein Domains for SFT2D2 Gene

Suggested Antigen Peptide Sequences for SFT2D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95562

UniProtKB/Swiss-Prot:

SFT2B_HUMAN :
  • O95562
Family:
  • Belongs to the SFT2 family.
genes like me logo Genes that share domains with SFT2D2: view

No data available for Gene Families for SFT2D2 Gene

Function for SFT2D2 Gene

Molecular function for SFT2D2 Gene

UniProtKB/Swiss-Prot Function: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.

Gene Ontology (GO) - Molecular Function for SFT2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SFT2D2: view

Animal Model Products

CRISPR Products

miRNA for SFT2D2 Gene

miRTarBase miRNAs that target SFT2D2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SFT2D2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SFT2D2 Gene

Localization for SFT2D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFT2D2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SFT2D2 Gene COMPARTMENTS Subcellular localization image for SFT2D2 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SFT2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SFT2D2: view

Pathways for SFT2D2 Gene

SuperPathways for SFT2D2 Gene

No Data Available

Interacting Proteins for SFT2D2 Gene

Gene Ontology (GO) - Biological Process for SFT2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with SFT2D2: view

No data available for Pathways by source for SFT2D2 Gene

Transcripts for SFT2D2 Gene

mRNA/cDNA for SFT2D2 Gene

Unigene Clusters for SFT2D2 Gene

SFT2 domain containing 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SFT2D2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SFT2D2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SFT2D2 Gene

No ASD Table

Relevant External Links for SFT2D2 Gene

GeneLoc Exon Structure for
SFT2D2
ECgene alternative splicing isoforms for
SFT2D2

Expression for SFT2D2 Gene

mRNA expression in normal human tissues for SFT2D2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SFT2D2 Gene

SOURCE GeneReport for Unigene cluster for SFT2D2 Gene Hs.645435

genes like me logo Genes that share expressions with SFT2D2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SFT2D2 Gene

Orthologs for SFT2D2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SFT2D2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SFT2D2 35
  • 99.79 (n)
  • 99.37 (a)
SFT2D2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SFT2D2 35
  • 90.42 (n)
  • 90 (a)
SFT2D2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SFT2D2 35
  • 87.42 (n)
  • 88.74 (a)
SFT2D2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sft2d2 35
  • 86.58 (n)
  • 91.82 (a)
Sft2d2 16
Sft2d2 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SFT2D2 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SFT2D2 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sft2d2 35
  • 88.11 (n)
  • 89.81 (a)
chicken
(Gallus gallus)
Aves SFT2D2 35
  • 74.58 (n)
  • 74.38 (a)
SFT2D2 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SFT2D2 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7785 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sft2d2 35
  • 70.62 (n)
  • 73.75 (a)
Str.6270 35
zebrafish
(Danio rerio)
Actinopterygii SFT2D2 (1 of 2) 36
  • 51 (a)
OneToMany
SFT2D2 (2 of 2) 36
  • 65 (a)
OneToMany
zgc64053 35
zgc:112392 35
  • 63.94 (n)
  • 66.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5104 36
  • 58 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F27D4.7 36
  • 32 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G23550 35
  • 48.9 (n)
  • 42.11 (a)
rice
(Oryza sativa)
Liliopsida Os02g0564500 35
  • 48.23 (n)
  • 38.3 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.278 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
Species with no ortholog for SFT2D2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SFT2D2 Gene

ENSEMBL:
Gene Tree for SFT2D2 (if available)
TreeFam:
Gene Tree for SFT2D2 (if available)

Paralogs for SFT2D2 Gene

Paralogs for SFT2D2 Gene

Selected SIMAP similar genes for SFT2D2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SFT2D2: view

Variants for SFT2D2 Gene

Sequence variations from dbSNP and Humsavar for SFT2D2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2235177 -- 168,237,138(-) CCTCT(A/G)TTGGA intron-variant
rs2235178 -- 168,233,725(-) CTTCT(A/G)GACTA intron-variant
rs2235179 -- 168,233,306(-) CAGGA(A/T)AAGCT intron-variant
rs2235180 -- 168,230,019(-) AACTG(A/G)GCTCA intron-variant
rs2235181 -- 168,228,182(-) GCCTG(C/G)AAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SFT2D2 Gene

Variant ID Type Subtype PubMed ID
nsv872526 CNV Gain 21882294
nsv831825 CNV Gain+Loss 17160897

Relevant External Links for SFT2D2 Gene

HapMap Linkage Disequilibrium report
SFT2D2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFT2D2 Gene

Disorders for SFT2D2 Gene

Relevant External Links for SFT2D2

Genetic Association Database (GAD)
SFT2D2
Human Genome Epidemiology (HuGE) Navigator
SFT2D2
genes like me logo Genes that share disorders with SFT2D2: view

No data available for UniProtKB/Swiss-Prot for SFT2D2 Gene

Publications for SFT2D2 Gene

  1. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PMID: 19064610) Cheung C.L. … Kung A.W. (Hum. Mol. Genet. 2009) 3 48
  2. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret G.B. … Chakravarti A. (Eur. J. Hum. Genet. 2009) 3 48
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SFT2D2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SFT2D2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for SFT2D2
  • Block miRNA regulation of SFT2D2 using miScript Target Protectors
  • antibodies-online peptides for SFT2D2
  • antibodies-online antibodies for SFT2D2
  • antibodies-online kits for SFT2D2

Sources for SFT2D2 Gene

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