Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SFT2D2 Gene

Aliases for SFT2D2 Gene

  • SFT2 Domain Containing 2 2 3 5
  • SFT2 Domain-Containing Protein 2 3 4
  • DJ747L4.C1.2 3
  • UNQ512 3

External Ids for SFT2D2 Gene

Previous GeneCards Identifiers for SFT2D2 Gene

  • GC01P164927
  • GC01P166462
  • GC01P166463
  • GC01P168195
  • GC01P139439

Summaries for SFT2D2 Gene

GeneCards Summary for SFT2D2 Gene

SFT2D2 (SFT2 Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is SFT2D1.

UniProtKB/Swiss-Prot for SFT2D2 Gene

  • May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFT2D2 Gene

Genomics for SFT2D2 Gene

Regulatory Elements for SFT2D2 Gene

Enhancers for SFT2D2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SFT2D2 on UCSC Golden Path with GeneCards custom track

Promoters for SFT2D2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SFT2D2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SFT2D2 Gene

168,225,938 bp from pter
168,253,025 bp from pter
27,088 bases
Plus strand

Genomic View for SFT2D2 Gene

Genes around SFT2D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFT2D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFT2D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFT2D2 Gene

Proteins for SFT2D2 Gene

  • Protein details for SFT2D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vesicle transport protein SFT2B
    Protein Accession:
    Secondary Accessions:
    • A8K2R0
    • Q6UWR8

    Protein attributes for SFT2D2 Gene

    160 amino acids
    Molecular mass:
    17779 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ89038.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SFT2D2 Gene

Proteomics data for SFT2D2 Gene at MOPED

Post-translational modifications for SFT2D2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SFT2D2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SFT2D2 Gene

Domains & Families for SFT2D2 Gene

Protein Domains for SFT2D2 Gene

Suggested Antigen Peptide Sequences for SFT2D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SFT2 family.
  • Belongs to the SFT2 family.
genes like me logo Genes that share domains with SFT2D2: view

No data available for Gene Families for SFT2D2 Gene

Function for SFT2D2 Gene

Molecular function for SFT2D2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.

Phenotypes for SFT2D2 Gene

GenomeRNAi human phenotypes for SFT2D2:
genes like me logo Genes that share phenotypes with SFT2D2: view

Animal Model Products

miRNA for SFT2D2 Gene

miRTarBase miRNAs that target SFT2D2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SFT2D2 Gene

Localization for SFT2D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFT2D2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SFT2D2 Gene COMPARTMENTS Subcellular localization image for SFT2D2 gene
Compartment Confidence
extracellular 5
plasma membrane 3
endosome 1
lysosome 1

No data available for Gene Ontology (GO) - Cellular Components for SFT2D2 Gene

Pathways & Interactions for SFT2D2 Gene

SuperPathways for SFT2D2 Gene

No Data Available

Interacting Proteins for SFT2D2 Gene

Gene Ontology (GO) - Biological Process for SFT2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SFT2D2: view

No data available for Pathways by source and SIGNOR curated interactions for SFT2D2 Gene

Drugs & Compounds for SFT2D2 Gene

No Compound Related Data Available

Transcripts for SFT2D2 Gene

Unigene Clusters for SFT2D2 Gene

SFT2 domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SFT2D2 Gene

No ASD Table

Relevant External Links for SFT2D2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SFT2D2 Gene

mRNA expression in normal human tissues for SFT2D2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SFT2D2 Gene

This gene is overexpressed in Nasal epithelium (46.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SFT2D2 Gene

SOURCE GeneReport for Unigene cluster for SFT2D2 Gene Hs.645435

genes like me logo Genes that share expression patterns with SFT2D2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SFT2D2 Gene

Orthologs for SFT2D2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SFT2D2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SFT2D2 35
  • 90.42 (n)
  • 90 (a)
SFT2D2 36
  • 90 (a)
(Canis familiaris)
Mammalia SFT2D2 35
  • 87.42 (n)
  • 88.74 (a)
SFT2D2 36
  • 94 (a)
(Mus musculus)
Mammalia Sft2d2 35
  • 86.58 (n)
  • 91.82 (a)
Sft2d2 16
Sft2d2 36
  • 92 (a)
(Pan troglodytes)
Mammalia SFT2D2 35
  • 99.79 (n)
  • 99.37 (a)
SFT2D2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Sft2d2 35
  • 88.11 (n)
  • 89.81 (a)
(Monodelphis domestica)
Mammalia SFT2D2 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia SFT2D2 36
  • 78 (a)
(Gallus gallus)
Aves SFT2D2 35
  • 74.58 (n)
  • 74.38 (a)
SFT2D2 36
  • 74 (a)
(Anolis carolinensis)
Reptilia SFT2D2 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sft2d2 35
  • 70.62 (n)
  • 73.75 (a)
Str.6270 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7785 35
(Danio rerio)
Actinopterygii zgc64053 35
zgc:112392 35
  • 63.94 (n)
  • 66.04 (a)
SFT2D2 (1 of 2) 36
  • 51 (a)
SFT2D2 (2 of 2) 36
  • 65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5104 36
  • 58 (a)
(Caenorhabditis elegans)
Secernentea F27D4.7 36
  • 32 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G23550 35
  • 48.9 (n)
  • 42.11 (a)
(Oryza sativa)
Liliopsida Os02g0564500 35
  • 48.23 (n)
  • 38.3 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.278 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
Species with no ortholog for SFT2D2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SFT2D2 Gene

Gene Tree for SFT2D2 (if available)
Gene Tree for SFT2D2 (if available)

Paralogs for SFT2D2 Gene

Paralogs for SFT2D2 Gene

(1) SIMAP similar genes for SFT2D2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SFT2D2: view

Variants for SFT2D2 Gene

Sequence variations from dbSNP and Humsavar for SFT2D2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2294218 -- 168,232,693(-) CATGC(A/T)AGTCA intron-variant
rs2235177 -- 168,237,138(-) CCTCT(A/G)TTGGA intron-variant
rs2235178 -- 168,233,725(-) CTTCT(A/G)GACTA intron-variant
rs2235179 -- 168,233,306(-) CAGGA(A/T)AAGCT intron-variant
rs2235180 -- 168,230,019(-) AACTG(A/G)GCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SFT2D2 Gene

Variant ID Type Subtype PubMed ID
nsv872526 CNV Gain 21882294
nsv831825 CNV Gain+Loss 17160897

Variation tolerance for SFT2D2 Gene

Residual Variation Intolerance Score: 59.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.37% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SFT2D2 Gene

Disorders for SFT2D2 Gene

Relevant External Links for SFT2D2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SFT2D2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SFT2D2 Gene

Publications for SFT2D2 Gene

  1. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret G.B. … Chakravarti A. (Eur. J. Hum. Genet. 2009) 3 48 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3
  5. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PMID: 19064610) Cheung C.L. … Kung A.W. (Hum. Mol. Genet. 2009) 3

Products for SFT2D2 Gene

Sources for SFT2D2 Gene