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Aliases for SFT2D2 Gene

Aliases for SFT2D2 Gene

  • SFT2 Domain Containing 2 2 3
  • SFT2 Domain-Containing Protein 2 3 4
  • DJ747L4.C1.2 3
  • UNQ512 3

External Ids for SFT2D2 Gene

Previous GeneCards Identifiers for SFT2D2 Gene

  • GC01P164927
  • GC01P166462
  • GC01P166463
  • GC01P168195
  • GC01P139439

Summaries for SFT2D2 Gene

GeneCards Summary for SFT2D2 Gene

SFT2D2 (SFT2 Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is SFT2D1.

UniProtKB/Swiss-Prot for SFT2D2 Gene

  • May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFT2D2 Gene

Genomics for SFT2D2 Gene

Regulatory Elements for SFT2D2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SFT2D2 Gene

Chromosome:
1
Start:
168,225,938 bp from pter
End:
168,253,025 bp from pter
Size:
27,088 bases
Orientation:
Plus strand

Genomic View for SFT2D2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for SFT2D2 Gene

Proteins for SFT2D2 Gene

  • Protein details for SFT2D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95562-SFT2B_HUMAN
    Recommended name:
    Vesicle transport protein SFT2B
    Protein Accession:
    O95562
    Secondary Accessions:
    • A8K2R0
    • Q6UWR8

    Protein attributes for SFT2D2 Gene

    Size:
    160 amino acids
    Molecular mass:
    17779 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ89038.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SFT2D2 Gene

Proteomics data for SFT2D2 Gene at MOPED

Post-translational modifications for SFT2D2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SFT2D2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SFT2D2 Gene

Domains & Families for SFT2D2 Gene

Protein Domains for SFT2D2 Gene

Suggested Antigen Peptide Sequences for SFT2D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95562

UniProtKB/Swiss-Prot:

SFT2B_HUMAN :
  • Belongs to the SFT2 family.
Family:
  • Belongs to the SFT2 family.
genes like me logo Genes that share domains with SFT2D2: view

No data available for Gene Families for SFT2D2 Gene

Function for SFT2D2 Gene

Molecular function for SFT2D2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.

Gene Ontology (GO) - Molecular Function for SFT2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SFT2D2: view

Phenotypes for SFT2D2 Gene

GenomeRNAi human phenotypes for SFT2D2:
genes like me logo Genes that share phenotypes with SFT2D2: view

Animal Model Products

miRNA for SFT2D2 Gene

miRTarBase miRNAs that target SFT2D2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SFT2D2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SFT2D2 Gene

Localization for SFT2D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFT2D2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SFT2D2 Gene COMPARTMENTS Subcellular localization image for SFT2D2 gene
Compartment Confidence
extracellular 5
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SFT2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SFT2D2: view

Pathways & Interactions for SFT2D2 Gene

SuperPathways for SFT2D2 Gene

No Data Available

Interacting Proteins for SFT2D2 Gene

Gene Ontology (GO) - Biological Process for SFT2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with SFT2D2: view

No data available for Pathways by source and SIGNOR curated interactions for SFT2D2 Gene

Drugs & Compounds for SFT2D2 Gene

No Compound Related Data Available

Transcripts for SFT2D2 Gene

mRNA/cDNA for SFT2D2 Gene

Unigene Clusters for SFT2D2 Gene

SFT2 domain containing 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SFT2D2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SFT2D2 Gene

No ASD Table

Relevant External Links for SFT2D2 Gene

GeneLoc Exon Structure for
SFT2D2
ECgene alternative splicing isoforms for
SFT2D2

Expression for SFT2D2 Gene

mRNA expression in normal human tissues for SFT2D2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SFT2D2 Gene

This gene is overexpressed in Nasal epithelium (46.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SFT2D2 Gene



SOURCE GeneReport for Unigene cluster for SFT2D2 Gene Hs.645435

genes like me logo Genes that share expression patterns with SFT2D2: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SFT2D2 Gene

Orthologs for SFT2D2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SFT2D2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SFT2D2 35
  • 90.42 (n)
  • 90 (a)
SFT2D2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SFT2D2 35
  • 87.42 (n)
  • 88.74 (a)
SFT2D2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sft2d2 35
  • 86.58 (n)
  • 91.82 (a)
Sft2d2 16
Sft2d2 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SFT2D2 35
  • 99.79 (n)
  • 99.37 (a)
SFT2D2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sft2d2 35
  • 88.11 (n)
  • 89.81 (a)
oppossum
(Monodelphis domestica)
Mammalia SFT2D2 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SFT2D2 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves SFT2D2 35
  • 74.58 (n)
  • 74.38 (a)
SFT2D2 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SFT2D2 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sft2d2 35
  • 70.62 (n)
  • 73.75 (a)
Str.6270 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7785 35
zebrafish
(Danio rerio)
Actinopterygii zgc64053 35
zgc:112392 35
  • 63.94 (n)
  • 66.04 (a)
SFT2D2 (1 of 2) 36
  • 51 (a)
OneToMany
SFT2D2 (2 of 2) 36
  • 65 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5104 36
  • 58 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F27D4.7 36
  • 32 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G23550 35
  • 48.9 (n)
  • 42.11 (a)
rice
(Oryza sativa)
Liliopsida Os02g0564500 35
  • 48.23 (n)
  • 38.3 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.278 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
Species with no ortholog for SFT2D2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SFT2D2 Gene

ENSEMBL:
Gene Tree for SFT2D2 (if available)
TreeFam:
Gene Tree for SFT2D2 (if available)

Paralogs for SFT2D2 Gene

Paralogs for SFT2D2 Gene

(1) SIMAP similar genes for SFT2D2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SFT2D2: view

Variants for SFT2D2 Gene

Sequence variations from dbSNP and Humsavar for SFT2D2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2235177 -- 168,237,138(-) CCTCT(A/G)TTGGA intron-variant
rs2235178 -- 168,233,725(-) CTTCT(A/G)GACTA intron-variant
rs2235179 -- 168,233,306(-) CAGGA(A/T)AAGCT intron-variant
rs2235180 -- 168,230,019(-) AACTG(A/G)GCTCA intron-variant
rs2235181 -- 168,228,182(-) GCCTG(C/G)AAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SFT2D2 Gene

Variant ID Type Subtype PubMed ID
nsv872526 CNV Gain 21882294
nsv831825 CNV Gain+Loss 17160897

Variation tolerance for SFT2D2 Gene

Residual Variation Intolerance Score: 59.88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SFT2D2 Gene

HapMap Linkage Disequilibrium report
SFT2D2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFT2D2 Gene

Disorders for SFT2D2 Gene

Relevant External Links for SFT2D2

Genetic Association Database (GAD)
SFT2D2
Human Genome Epidemiology (HuGE) Navigator
SFT2D2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SFT2D2
genes like me logo Genes that share disorders with SFT2D2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SFT2D2 Gene

Publications for SFT2D2 Gene

  1. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  2. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 67
  3. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 67
  4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 67
  5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 67

Products for SFT2D2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SFT2D2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for SFT2D2
  • Block miRNA regulation of SFT2D2 using miScript Target Protectors

Sources for SFT2D2 Gene

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