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SFT2D2 Gene

protein-coding   GIFtS: 47
GCID: GC01P168195

SFT2 Domain Containing 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SFT2 Domain Containing 21 2
SFT2 Domain-Containing Protein 22 3
UNQ5122
dJ747L4.C1.22
Vesicle Transport Protein SFT2B2

External Ids:    HGNC: 251401   Entrez Gene: 3750352   Ensembl: ENSG000002130647   UniProtKB: O955623   

Export aliases for SFT2D2 gene to outside databases

Previous GC identifers: GC01P164927 GC01P166462 GC01P166463 GC01P139439


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SFT2D2 Gene:
SFT2D2 (SFT2 domain containing 2) is a protein-coding gene. Diseases associated with SFT2D2 include essential hypertension, and hypertension. An important paralog of this gene is SFT2D1.

UniProtKB/Swiss-Prot: SFT2B_HUMAN, O95562
Function: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with
the Golgi complex (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the SFT2D2 gene promoter:
         NF-YA   YY1   MEF-2A   NF-YB   CBF-A   CBF-B   CP1A   aMEF-2   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSFT2D2 promoter sequence
   Search Chromatin IP Primers for SFT2D2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SFT2D2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24.2   Ensembl cytogenetic band:  1q24.2   HGNC cytogenetic band: 1q24.2

SFT2D2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SFT2D2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P168195:  view genomic region     (about GC identifiers)

Start:
168,195,176 bp from pter      End:
168,222,263 bp from pter
Size:
27,088 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SFT2B_HUMAN, O95562 (See protein sequence)
Recommended Name: Vesicle transport protein SFT2B  
Size: 160 amino acids; 17779 Da
Sequence caution: Sequence=AAQ89038.1; Type=Erroneous initiation;
Secondary accessions: A8K2R0 Q6UWR8

Explore the universe of human proteins at neXtProt for SFT2D2: NX_O95562

Explore proteomics data for SFT2D2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys6
  • Modification sites at PhosphoSitePlus

  • See SFT2D2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_955376.1  
    ENSEMBL proteins: 
     ENSP00000356803   ENSP00000271375   ENSP00000356799  

    SFT2D2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR007305 Vesicle_transpt_Got1/SFT2
     IPR011691 Vesicle_transpt_SFT2

    Graphical View of Domain Structure for InterPro Entry O95562

    ProtoNet protein and cluster: O95562

    UniProtKB/Swiss-Prot: SFT2B_HUMAN, O95562
    Similarity: Belongs to the SFT2 family


    SFT2D2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SFT2B_HUMAN, O95562
    Function: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with
    the Golgi complex (By similarity)

    Animal Models:

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SFT2D2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SFT2D2

    miRNA
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    miRTarBase miRNAs that target SFT2D2:
    hsa-mir-375 (MIRT019903)

    Block miRNA regulation of human, mouse, rat SFT2D2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate SFT2D2:
    hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidSFT2D2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SFT2D2
    Predesigned siRNA for gene silencing in human, mouse, rat SFT2D2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SFT2D2 (NM_199344)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFT2D2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFT2D2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SFT2B_HUMAN, O95562: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    SFT2D2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SFT2D2
    Interactions:

        Search GeneGlobe Interaction Network for SFT2D2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for SFT2D2 (O955623 ENSP000002713754) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIAH1Q8IUQ43I2D: score=5 
    COG6ENSP000003974414STRING: ENSP00000397441
    COG8ENSP000003054594STRING: ENSP00000305459
    GOLT1AENSP000003085354STRING: ENSP00000308535
    GOLT1BENSP000002293144STRING: ENSP00000229314
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--
    GO:0016192vesicle-mediated transport IEA--

    SFT2D2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SFT2D2 (SFT2B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SFT2D2 gene: 
    NM_199344.2  

    Unigene Cluster for SFT2D2:

    SFT2 domain containing 2
    Hs.645435  [show with all ESTs]
    Unigene Representative Sequence: AL035297
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000471981 ENST00000367829 ENST00000271375(uc001gfi.4) ENST00000367825

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate SFT2D2:
    hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidSFT2D2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SFT2D2
    Predesigned siRNA for gene silencing in human, mouse, rat SFT2D2
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SFT2D2 (NM_199344)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SFT2D2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFT2D2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SFT2D2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SFT2D2
      QuantiTect SYBR Green Assays in human, mouse, rat SFT2D2
      QuantiFast Probe-based Assays in human, mouse, rat SFT2D2

    Additional mRNA sequence: 

    AK290325.1 AL035297.1 AY358675.1 BC068098.1 

    5 DOTS entries:

    DT.106153  DT.102823903  DT.121452822  DT.95183215  DT.95364784 

    Selected AceView cDNA sequences (see all 59):

    AI299558 BQ882680 AK129813 CD365919 NM_199344 AI299815 AK091404 AA676929 
    AX746960 CA308141 BC068098 AX747228 BX956478 CB853017 AI655882 NM_005149 
    CB850837 AI633344 AL035297 AI142087 BX280470 AA983219 BF111697 AK091862 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SFT2D2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATACAAACC
    SFT2D2 Expression
    About this image


    SFT2D2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
     
     Colon (Gastrointestinal Tract)
    SFT2D2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SFT2D2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.645435
        Custom PCR Arrays for SFT2D2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFT2D2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SFT2D2 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sft2d21 , 5 SFT2 domain containing 21, 5 86.58(n)1
    91.82(a)1
      1 (72.51 cM)5
    1087351  NM_145512.41  NP_663487.11 
     1651743415 
    chicken
    (Gallus gallus)
    Aves SFT2D21 SFT2 domain containing 2 74.58(n)
    74.38(a)
      418373  XM_416592.4  XP_416592.1 
    lizard
    (Anolis carolinensis)
    Reptilia SFT2D26
    SFT2 domain containing 2
    81(a)
    1 ↔ 1
    3(175104604-175123679)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.77852 Xenopus laevis transcribed sequence with strong similarity more 72.92(n)    CA982995.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc640532 hypothetical protein MGC64053 74.08(n)   393343  BC053226.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG51046
    --
    58(a)
    1 → many
    3L(20514109-20515535)
    worm
    (Caenorhabditis elegans)
    Secernentea F27D4.76
    Protein F27D4.7 (F27D4.7) mRNA, complete cds
    32(a)
    1 → many
    I(7723750-7724654) WBGene00009191
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G235501 AT5G23550 48.9(n)
    42.11(a)
      832421  NM_122262.2  NP_197746.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g05645001 Os02g0564500 48.23(n)
    38.3(a)
      4329697  NM_001053696.1  NP_001047161.1 


    ENSEMBL Gene Tree for SFT2D2 (if available)
    TreeFam Gene Tree for SFT2D2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SFT2D2 gene
    SFT2D12  
    1 SIMAP similar gene for SFT2D2 using alignment to 2 protein entries:     SFT2B_HUMAN (see all proteins):
    SFT2D1

    SFT2D2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SFT2D2 (see all 446)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1409229121,2
    Cuntested1168204394(+) CTACTC/TGTTTG 2 R C mis10--------
    rs1398135241,2
    C--168193348(+) GACACA/CTTGGA 1 -- us2k10--------
    rs75473401,2
    C,F,A,H--168193361(+) AAGATA/GAGAGT 1 -- us2k14Minor allele frequency- G:0.00NS EA 418
    rs781203711,2
    C,F--168193375(+) TGCCTG/ATTACA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1467102671,2
    --168193480(+) CCATAC/TAGTTA 1 -- us2k10--------
    rs1872219421,2
    --168193530(+) AGCTGC/TGCATG 1 -- us2k10--------
    rs1488455381,2
    --168193609(+) TCCTCC/TATCCC 1 -- us2k10--------
    rs1920283791,2
    --168193716(+) GCTTCC/TGTGAA 1 -- us2k10--------
    rs1846082291,2
    --168193739(+) TGGGCC/TCCCCC 1 -- us2k10--------
    rs283735561,2
    C--168193829(+) TTCACT/GGAGAT 1 -- us2k12Minor allele frequency- G:0.00NA 4

    HapMap Linkage Disequilibrium report for SFT2D2 (168195176 - 168222263 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SFT2D2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv872526CNV Gain21882294
    nsv831825CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SFT2D2
    DNA2.0 Custom Variant and Variant Library Synthesis for SFT2D2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    4 diseases for SFT2D2:    
    About MalaCards
    essential hypertension    hypertension    t-cell leukemia    leukemia


    SFT2D2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SFT2D2
    Human Genome Epidemiology (HuGE) Navigator: SFT2D2 (2 documents)

    Export disorders for SFT2D2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SFT2D2 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with SFT2D2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (Eur. J. Hum. Genet. 2009)
    2. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PubMed id 19064610)1, 4 Cheung C.L....Kung A.W. (Hum. Mol. Genet. 2009)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    7. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 375035 HGNC: 25140 AceView: TBX19 Ensembl:ENSG00000213064 euGenes: HUgn375035
    ECgene: SFT2D2 H-InvDB: SFT2D2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SFT2D2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SFT2D2 gene:
    Search GeneIP for patents involving SFT2D2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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