SFT2D2 Gene
protein-coding GIFtS: 43
GCID: GC01P168195
|
|
SFT2 domain containing 2
| |
Aliases
for SFT2D2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SFT2 Domain Containing 21 2 | | UNQ5121 2 | | DJ747L4.C1.21 | | SFT2 Domain-Containing Protein 22 3 | | Vesicle Transport Protein SFT2B2 |
Export aliases for SFT2D2 gene to outside databasesPrevious GC identifers: GC01P164927 GC01P166462 GC01P166463 GC01P139439 |
Summaries
for SFT2D2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SFT2B_HUMAN, O95562Function: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with theGolgi complex (By similarity)
|
Genomic Views
for SFT2D2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SFT2D2 gene promoter:
NF-YA YY1 MEF-2A NF-YB CBF-A CBF-B CP1A aMEF-2 NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for SFT2D2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SFT2D2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q24.2 Ensembl cytogenetic band: 1q24.2 HGNC cytogenetic band: 1q24.2SFT2D2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P168195: view genomic region
(about GC identifiers)
Start:
|
168,195,176 bp from pter |
End:
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168,212,378 bp from pter |
Size:
|
17,203 bases |
Orientation:
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plus strand |
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Proteins
for SFT2D2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SFT2B_HUMAN, O95562 (See
protein sequence)Recommended Name: Vesicle transport protein SFT2B Size: 160 amino acids; 17779 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAQ89038.1; Type=Erroneous initiation;
Secondary accessions: A8K2R0 Q6UWR8Explore the universe of human proteins at neXtProt for SFT2D2: NX_O95562
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95562
SFT2D2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_955376.1
ENSEMBL proteins: ENSP00000356803 ENSP00000271375 ENSP00000356799
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
SFT2D2 for ontologies About GeneDecksing
SFT2D2 Antibody Products:
Assay Products for SFT2D2: |
Protein
Domains /
Families
for SFT2D2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SFT2D2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95562ProtoNet protein and cluster: O95562 UniProtKB/Swiss-Prot: SFT2B_HUMAN, O95562Similarity: Belongs to the SFT2 family |
Function
for SFT2D2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SFT2B_HUMAN, O95562Function: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with theGolgi complex (By similarity)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFT2D2
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFT2D2 |
|
Pathways & Interactions
for SFT2D2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SFT2D2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for SFT2D2 (O955623 ENSP000002713754) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015031 | protein transport |
IEA | -- | | GO:0016192 | vesicle-mediated transport |
IEA | -- |
SFT2D2 for ontologies About GeneDecksing
|
Drugs & Compounds
for SFT2D2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SFT2D2
Search CenterWatch for drugs/clinical trials and news about SFT2D2 / SFT2B
|
Transcripts
for SFT2D2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SFT2D2 gene: NM_199344.2 Unigene Cluster for SFT2D2: SFT2 domain containing 2 Hs.645435 [show with all ESTs]Unigene Representative Sequence: AL0352974 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000471981 ENST00000367829 ENST00000271375(uc001gfi.4) ENST00000367825
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFT2D2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFT2D2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SFT2D2 (NM_199344) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SFT2D2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFT2D2 |
Additional cDNA sequence: AK290325.1 AL035297.1 AY358675.1 BC068098.1 5 DOTS entries: DT.106153 DT.102823903 DT.121452822 DT.95183215 DT.95364784 24/59 AceView cDNA sequences (see all 59): AW467021 AI142087 AI953686 BX280470 CA308141 AK129813 AK091404 BQ882680 CD365919 NM_199344 AK091862 AI299558 AA983219 BF115008 AI299815 AY358675 AX747228 AJ010277 CB850837 AX746960 CB853017 BE504539 NM_005149 BC068098
GeneLoc Exon Structure
|
Expression
for SFT2D2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SFT2D2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATACAAACC
About this image
See SFT2D2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SFT2D2
SOURCE GeneReport for Unigene cluster: Hs.645435
SABiosciences Custom PCR Arrays for SFT2D2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SFT2D2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SFT2D2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SFT2D2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SFT2D2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFT2D2 |
Orthologs
for SFT2D2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SFT2D2 gene from 8/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SFT2D21 |
SFT2 domain containing 2 |
74.58(n)
74.38(a) |
|
418373 XM_416592.3 XP_416592.1 |
lizard
(Anolis carolinensis) |
Reptilia |
SFT2D26 |
-- |
81(a) |
1 ↔ 1 |
3(175104750-175123676) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.77852 |
Xenopus laevis transcribed sequence with strong similarity more |
72.92(n) |
|
CA982995.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc640532 |
hypothetical protein MGC64053 |
74.08(n) |
|
393343 BC053226.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG51046 |
-- |
58(a) |
1 → many |
3L(20514109-20515535) |
worm
(Caenorhabditis elegans) |
Secernentea |
F27D4.76 |
-- |
33(a) |
1 → many |
I(7723746-7724650) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G235501 |
Got1/Sft2-like vescicle transport protein |
48.9(n)
42.11(a) |
|
832421 NM_122262.2 NP_197746.1 |
rice
(Oryza sativa) |
Liliopsida |
Os02g05645001 |
hypothetical protein |
48.23(n)
38.3(a) |
|
4329697 NM_001053696.1 NP_001047161.1 |
ENSEMBL Gene Tree for SFT2D2 (if available)
TreeFam Gene Tree for SFT2D2 (if available) |
Paralogs
for SFT2D2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SFT2D2 gene
- SFT2D12
1 SIMAP similar gene for SFT2D2 using alignment to 2 protein entries: SFT2B_HUMAN (see all proteins):SFT2D1
SFT2D2 for paralogs About GeneDecksing
|
Genomic Variants
for SFT2D2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SFT2D2 (168195176 - 168212378 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SFT2D2
2 CNVs: 74771 4261 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SFT2D2 |
|
Disorders
/ Diseases
for SFT2D2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SFT2D2 for disorders About GeneDecksing
4  diseases for SFT2D2: About MalaCardsessential hypertension hypertension t-cell leukemia leukemia
Human Genome Epidemiology (HuGE) Navigator: SFT2D2 (2 documents)
Export disorders for SFT2D2 gene to outside databases
|
Publications
for SFT2D2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SFT2D2 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with SFT2D2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
|
External Searches for SFT2D2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SFT2D2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SFT2D2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SFT2D2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SFT2D2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SFT2D2 gene:
Search GeneIP for patents involving SFT2D2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SFT2D2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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