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Aliases for SFT2D2 Gene

Aliases for SFT2D2 Gene

  • SFT2 Domain Containing 2 2 3 5
  • SFT2 Domain-Containing Protein 2 3 4
  • Vesicle Transport Protein SFT2B 3
  • DJ747L4.C1.2 3
  • UNQ512 3

External Ids for SFT2D2 Gene

Previous GeneCards Identifiers for SFT2D2 Gene

  • GC01P164927
  • GC01P166462
  • GC01P166463
  • GC01P168195
  • GC01P139439

Summaries for SFT2D2 Gene

GeneCards Summary for SFT2D2 Gene

SFT2D2 (SFT2 Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is SFT2D1.

UniProtKB/Swiss-Prot for SFT2D2 Gene

  • May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFT2D2 Gene

Genomics for SFT2D2 Gene

Regulatory Elements for SFT2D2 Gene

Enhancers for SFT2D2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F168202 1.2 Ensembl ENCODE 12.5 -22.6 -22624 1.6 ZFP64 ARID4B DMAP1 THRB ZNF366 HMG20B CEBPB KAT8 RCOR2 IKZF1 TIPRL SFT2D2 MPC2 RPL34P1
GH01F168135 0.2 ENCODE 10.5 -89.2 -89209 2.3 ZFP64 ZNF76 KLF17 SIN3A GLI4 ZNF2 GLIS2 ZNF366 SP3 REST TIPRL SFT2D2 MPC2 GPR161 GC01M168079
GH01F168300 0.9 Ensembl ENCODE 10.5 +75.8 75826 2.6 GTF2F1 ESRRA MXI1 JUN MAX SIN3A RAD21 BRCA1 RFX5 NFYB TBX19 MIR557 SFT2D2 LOC441914
GH01F168145 1 Ensembl ENCODE 10 -79.7 -79738 1.6 CTCF PKNOX1 CBX3 MAX RAD21 ZNF143 SMC3 CREM TCF7L2 TRIM22 TIPRL SFT2D2 MPZL1 TBX19 GPR161
GH01F168079 1.4 FANTOM5 Ensembl ENCODE 1.5 -144.8 -144815 3.6 HDGF CBX3 ZNF76 FEZF1 ZNF2 RAD21 RFX5 ZNF143 FOS CREM MPC2 SFT2D2 GC01M168079 GPR161
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SFT2D2 on UCSC Golden Path with GeneCards custom track

Promoters for SFT2D2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001405025 662 2401 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 CBX5 ZNF143 KLF13

Genomic Location for SFT2D2 Gene

Chromosome:
1
Start:
168,225,938 bp from pter
End:
168,253,025 bp from pter
Size:
27,088 bases
Orientation:
Plus strand

Genomic View for SFT2D2 Gene

Genes around SFT2D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFT2D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFT2D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFT2D2 Gene

Proteins for SFT2D2 Gene

  • Protein details for SFT2D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95562-SFT2B_HUMAN
    Recommended name:
    Vesicle transport protein SFT2B
    Protein Accession:
    O95562
    Secondary Accessions:
    • A8K2R0
    • Q6UWR8

    Protein attributes for SFT2D2 Gene

    Size:
    160 amino acids
    Molecular mass:
    17779 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ89038.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SFT2D2 Gene

Post-translational modifications for SFT2D2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SFT2D2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SFT2D2 Gene

Domains & Families for SFT2D2 Gene

Protein Domains for SFT2D2 Gene

Suggested Antigen Peptide Sequences for SFT2D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95562

UniProtKB/Swiss-Prot:

SFT2B_HUMAN :
  • Belongs to the SFT2 family.
Family:
  • Belongs to the SFT2 family.
genes like me logo Genes that share domains with SFT2D2: view

No data available for Gene Families for SFT2D2 Gene

Function for SFT2D2 Gene

Molecular function for SFT2D2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.

Gene Ontology (GO) - Molecular Function for SFT2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SFT2D2: view

Phenotypes for SFT2D2 Gene

GenomeRNAi human phenotypes for SFT2D2:
genes like me logo Genes that share phenotypes with SFT2D2: view

Animal Model Products

miRNA for SFT2D2 Gene

miRTarBase miRNAs that target SFT2D2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SFT2D2 Gene

Localization for SFT2D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFT2D2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SFT2D2 Gene COMPARTMENTS Subcellular localization image for SFT2D2 gene
Compartment Confidence
extracellular 5
plasma membrane 3
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SFT2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,IBA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SFT2D2: view

Pathways & Interactions for SFT2D2 Gene

SuperPathways for SFT2D2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SFT2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008150 biological_process ND --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA,IBA --
genes like me logo Genes that share ontologies with SFT2D2: view

No data available for Pathways by source and SIGNOR curated interactions for SFT2D2 Gene

Transcripts for SFT2D2 Gene

Unigene Clusters for SFT2D2 Gene

SFT2 domain containing 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SFT2D2 Gene

No ASD Table

Relevant External Links for SFT2D2 Gene

GeneLoc Exon Structure for
SFT2D2
ECgene alternative splicing isoforms for
SFT2D2

Expression for SFT2D2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SFT2D2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SFT2D2 Gene

This gene is overexpressed in Nasal epithelium (46.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SFT2D2 Gene



NURSA nuclear receptor signaling pathways regulating expression of SFT2D2 Gene:

SFT2D2

SOURCE GeneReport for Unigene cluster for SFT2D2 Gene:

Hs.645435
genes like me logo Genes that share expression patterns with SFT2D2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SFT2D2 Gene

Orthologs for SFT2D2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SFT2D2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SFT2D2 34 35
  • 99.79 (n)
cow
(Bos Taurus)
Mammalia SFT2D2 34 35
  • 90.42 (n)
rat
(Rattus norvegicus)
Mammalia Sft2d2 34
  • 88.11 (n)
dog
(Canis familiaris)
Mammalia SFT2D2 34 35
  • 87.42 (n)
mouse
(Mus musculus)
Mammalia Sft2d2 34 16 35
  • 86.58 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SFT2D2 35
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SFT2D2 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves SFT2D2 34 35
  • 74.58 (n)
lizard
(Anolis carolinensis)
Reptilia SFT2D2 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sft2d2 34
  • 70.62 (n)
Str.6270 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7785 34
zebrafish
(Danio rerio)
Actinopterygii SFT2D2 (2 of 2) 35
  • 65 (a)
OneToMany
zgc:112392 34
  • 63.94 (n)
SFT2D2 (1 of 2) 35
  • 51 (a)
OneToMany
zgc64053 34
fruit fly
(Drosophila melanogaster)
Insecta CG5104 35
  • 58 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F27D4.7 35
  • 32 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G23550 34
  • 48.9 (n)
rice
(Oryza sativa)
Liliopsida Os02g0564500 34
  • 48.23 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.278 34
Species where no ortholog for SFT2D2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SFT2D2 Gene

ENSEMBL:
Gene Tree for SFT2D2 (if available)
TreeFam:
Gene Tree for SFT2D2 (if available)

Paralogs for SFT2D2 Gene

Paralogs for SFT2D2 Gene

(1) SIMAP similar genes for SFT2D2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SFT2D2: view

Variants for SFT2D2 Gene

Sequence variations from dbSNP and Humsavar for SFT2D2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10918852 -- 168,226,759(+) ACTAG(A/T)CTCTA intron-variant
rs10918853 -- 168,227,420(+) TTATT(C/G)GGTTT intron-variant
rs111559294 -- 168,226,303(+) TGGCA(C/G)TACAC intron-variant
rs111569379 -- 168,226,358(+) CCCAT(C/T)CTCCC intron-variant
rs111772567 -- 168,242,165(+) ATTTT(C/G)ACCGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SFT2D2 Gene

Variant ID Type Subtype PubMed ID
nsv1002007 CNV gain 25217958
nsv1078878 OTHER inversion 25765185
nsv831825 CNV gain+loss 17160897

Variation tolerance for SFT2D2 Gene

Residual Variation Intolerance Score: 59.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SFT2D2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SFT2D2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFT2D2 Gene

Disorders for SFT2D2 Gene

Relevant External Links for SFT2D2

Genetic Association Database (GAD)
SFT2D2
Human Genome Epidemiology (HuGE) Navigator
SFT2D2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SFT2D2

No disorders were found for SFT2D2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SFT2D2 Gene

Publications for SFT2D2 Gene

  1. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PMID: 19064610) Cheung C.L. … Kung A.W. (Hum. Mol. Genet. 2009) 3 46 64
  2. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret G.B. … Chakravarti A. (Eur. J. Hum. Genet. 2009) 3 46 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SFT2D2 Gene

Sources for SFT2D2 Gene

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