SFT2D1 Gene
protein-coding GIFtS: 43
GCID: GC06M166654
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SFT2 domain containing 1(Previous name: chromosome 6 open reading frame 83 )
(Previous symbol: C6orf83)
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Aliases
for SFT2D1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SFT2 Domain Containing 11 2 | | MGC198251 | | C6orf831 2 3 | | Chromosome 6 Open Reading Frame 831 | | PRGR11 | | Vesicle Transport Protein SFT2A2 | | SFT2 Domain-Containing Protein 12 3 | | |
Export aliases for SFT2D1 gene to outside databasesPrevious GC identifers: GC06M166704 GC06M164204 |
Summaries
for SFT2D1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SFT2A_HUMAN, Q8WV19Function: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with theGolgi complex (By similarity)
|
Genomic Views
for SFT2D1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SFT2D1 gene promoter:
AP-4 E47 Meis-1b c-Ets-1 IRF-2 FOXC1 POU2F1c Meis-1a En-1 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SFT2D1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SFT2D1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q27 Ensembl cytogenetic band: 6q27 HGNC cytogenetic band: 6q27SFT2D1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M166654: view genomic region
(about GC identifiers)
Start:
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166,733,216 bp from pter |
End:
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166,756,079 bp from pter |
Size:
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22,864 bases |
Orientation:
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minus strand |
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Proteins
for SFT2D1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SFT2A_HUMAN, Q8WV19 (See
protein sequence)Recommended Name: Vesicle transport protein SFT2A Size: 159 amino acids; 17804 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAF18564.1; Type=Erroneous initiation;
Secondary accessions: Q5TI64 Q9UIC7Explore the universe of human proteins at neXtProt for SFT2D1: NX_Q8WV19
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WV19
SFT2D1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_660152.1
ENSEMBL proteins: ENSP00000354590
Human Recombinant Protein Products for SFT2D1:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
SFT2D1 for ontologies About GeneDecksing
SFT2D1 Antibody Products:
Assay Products for SFT2D1: |
Protein
Domains /
Families
for SFT2D1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SFT2D1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WV19ProtoNet protein and cluster: Q8WV19 UniProtKB/Swiss-Prot: SFT2A_HUMAN, Q8WV19Similarity: Belongs to the SFT2 family |
Function
for SFT2D1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SFT2A_HUMAN, Q8WV19Function: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with theGolgi complex (By similarity)Phenotypes:
1 GenomeRNAi human phenotype for SFT2D1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFT2D1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFT2D1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SFT2D1 (NM_145169) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SFT2D1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFT2D1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFT2D1 |
|
Pathways & Interactions
for SFT2D1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SFT2D1
1 Interacting protein for SFT2D1 (Q8WV193) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015031 | protein transport |
IEA | -- | | GO:0016192 | vesicle-mediated transport |
IEA | -- |
SFT2D1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SFT2D1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SFT2D1
Search CenterWatch for drugs/clinical trials and news about SFT2D1 / SFT2A
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Transcripts
for SFT2D1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SFT2D1 gene: NM_145169.1 Unigene Cluster for SFT2D1: SFT2 domain containing 1 Hs.487143 [show with all ESTs]Unigene Representative Sequence: AL8332176 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000361731(uc003qux.3) ENST00000487841 ENST00000479490 ENST00000478705
ENST00000488773 ENST00000494682
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFT2D1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFT2D1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SFT2D1 (NM_145169) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SFT2D1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFT2D1 |
Additional cDNA sequence: AF041429.1 AK021489.1 AK090795.1 AL832690.1 AL833217.1 BC018969.1 BC028388.1 14 DOTS entries: DT.445020 DT.91962764 DT.100761892 DT.99930512 DT.95286873 DT.100761890 DT.40131894 DT.95256834 DT.95280689 DT.91965435 DT.100648774 DT.91767628 DT.121367132 DT.40126889 24/156 AceView cDNA sequences (see all 156): AA485179 BX354406 AI908082 BE006748 AI815979 BQ446536 AL712341 BE006749 D62795 AI878998 BE006747 AI879497 AI816062 AI040158 BX354407 BQ023883 AW955053 CA414057 BX385677 CK820799 CA412928 BV176852 CB161192 BG533909
GeneLoc Exon Structure
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Expression
for SFT2D1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SFT2D1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTGATTAAA
About this image
See SFT2D1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SFT2D1
SOURCE GeneReport for Unigene cluster: Hs.487143
SABiosciences Custom PCR Arrays for SFT2D1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SFT2D1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SFT2D1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SFT2D1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SFT2D1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFT2D1 |
Orthologs
for SFT2D1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SFT2D1 gene from 8/24 species (see all 24) About this table
ENSEMBL Gene Tree for SFT2D1 (if available)
TreeFam Gene Tree for SFT2D1 (if available) |
Paralogs
for SFT2D1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SFT2D1 gene
- SFT2D22
1 SIMAP similar gene for SFT2D1 using alignment to 2 protein entries: SFT2A_HUMAN (see all proteins):SFT2D2
SFT2D1 for paralogs About GeneDecksing
|
Genomic Variants
for SFT2D1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SFT2D1 (166733216 - 166756079 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SFT2D1
3 CNVs: 94204 94203 81724 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SFT2D1 |
|
Disorders
/ Diseases
for SFT2D1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SFT2D1 for disorders About MalaCards
SFT2D1 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: SFT2D1 (1 document)
Export disorders for SFT2D1 gene to outside databases
|
Publications
for SFT2D1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SFT2D1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SFT2D1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for SFT2D1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SFT2D1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SFT2D1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SFT2D1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SFT2D1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SFT2D1 gene:
Search GeneIP for patents involving SFT2D1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SFT2D1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SFT2D1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SFT2D1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SFT2D1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SFT2D1 | | OriGene 3'-UTR Clone for SFT2D1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFT2D1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFT2D1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SFT2D1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SFT2D1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SFT2D1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SFT2D1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SFT2D1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SFT2D1 |
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| | | | Search Tocris compounds for SFT2D1 |
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 | | | SFT2D1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFT2D1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for SFT2D1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFT2D1 |
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