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Aliases for SFSWAP Gene

Aliases for SFSWAP Gene

  • Splicing Factor, Suppressor Of White-Apricot Family 2 3
  • Splicing Factor, Arginine/Serine-Rich 8 (Suppressor-Of-White-Apricot, Drosophila Homolog) 2 3
  • Splicing Factor, Arginine/Serine-Rich 8 (Suppressor-Of-White-Apricot Homolog, Drosophila) 2 3
  • Suppressor Of White Apricot Protein Homolog 3 4
  • SFRS8 3 4
  • SWAP 3 4
  • Splicing Factor, Suppressor Of White-Apricot Homolog (Drosophila) 2
  • Splicing Factor, Arginine/Serine-Rich 8 4

External Ids for SFSWAP Gene

Previous HGNC Symbols for SFSWAP Gene

  • SFRS8

Previous GeneCards Identifiers for SFSWAP Gene

  • GC12P132196

Summaries for SFSWAP Gene

Entrez Gene Summary for SFSWAP Gene

  • This gene encodes a human homolog of Drosophila splicing regulatory protein. This gene autoregulates its expression by control of splicing of its first two introns. In addition, it also regulates the splicing of fibronectin and CD45 genes. Two transcript variants encoding different isoforms have been identified. [provided by RefSeq, May 2012]

GeneCards Summary for SFSWAP Gene

SFSWAP (Splicing Factor, Suppressor Of White-Apricot Family) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for SFSWAP Gene

  • Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFSWAP Gene

Genomics for SFSWAP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SFSWAP Gene

Chromosome:
12
Start:
131,711,081 bp from pter
End:
131,799,738 bp from pter
Size:
88,658 bases
Orientation:
Plus strand

Genomic View for SFSWAP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SFSWAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFSWAP Gene

No data available for Regulatory Elements for SFSWAP Gene

Proteins for SFSWAP Gene

  • Protein details for SFSWAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12872-SFSWA_HUMAN
    Recommended name:
    Splicing factor, suppressor of white-apricot homolog
    Protein Accession:
    Q12872
    Secondary Accessions:
    • B2RN45
    • B7ZM97
    • F5H6B8
    • Q6PJF7

    Protein attributes for SFSWAP Gene

    Size:
    951 amino acids
    Molecular mass:
    104822 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SFSWAP Gene

    Alternative splice isoforms for SFSWAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SFSWAP Gene

Proteomics data for SFSWAP Gene at MOPED

Post-translational modifications for SFSWAP Gene

  • Ubiquitination at Lys 473
  • Modification sites at PhosphoSitePlus

Other Protein References for SFSWAP Gene

No data available for DME Specific Peptides for SFSWAP Gene

Domains & Families for SFSWAP Gene

Protein Domains for SFSWAP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SFSWAP Gene

Graphical View of Domain Structure for InterPro Entry

Q12872

UniProtKB/Swiss-Prot:

SFSWA_HUMAN :
  • Contains 2 SURP motif repeats.
Similarity:
  • Contains 2 SURP motif repeats.
genes like me logo Genes that share domains with SFSWAP: view

No data available for Gene Families for SFSWAP Gene

Function for SFSWAP Gene

Molecular function for SFSWAP Gene

UniProtKB/Swiss-Prot Function:
Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10.

Gene Ontology (GO) - Molecular Function for SFSWAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with SFSWAP: view

Phenotypes for SFSWAP Gene

GenomeRNAi human phenotypes for SFSWAP:
genes like me logo Genes that share phenotypes with SFSWAP: view

Animal Model Products

CRISPR Products

miRNA for SFSWAP Gene

miRTarBase miRNAs that target SFSWAP

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SFSWAP Gene

Localization for SFSWAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFSWAP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SFSWAP Gene COMPARTMENTS Subcellular localization image for SFSWAP gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SFSWAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SFSWAP: view

Pathways & Interactions for SFSWAP Gene

SuperPathways for SFSWAP Gene

Superpath Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with SFSWAP: view

Pathways by source for SFSWAP Gene

1 BioSystems pathway for SFSWAP Gene

Interacting Proteins for SFSWAP Gene

Gene Ontology (GO) - Biological Process for SFSWAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006376 mRNA splice site selection --
GO:0006396 RNA processing --
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with SFSWAP: view

No data available for SIGNOR curated interactions for SFSWAP Gene

Drugs & Compounds for SFSWAP Gene

No Compound Related Data Available

Transcripts for SFSWAP Gene

Unigene Clusters for SFSWAP Gene

Splicing factor, suppressor of white-apricot homolog (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SFSWAP Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - -
SP2:
SP3: - -
SP4: -
SP5: -
SP6:
SP7: -
SP8:

ExUns: 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for SFSWAP Gene

GeneLoc Exon Structure for
SFSWAP
ECgene alternative splicing isoforms for
SFSWAP

Expression for SFSWAP Gene

mRNA expression in normal human tissues for SFSWAP Gene

Protein differential expression in normal tissues from HIPED for SFSWAP Gene

This gene is overexpressed in Nasal epithelium (52.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SFSWAP Gene



SOURCE GeneReport for Unigene cluster for SFSWAP Gene Hs.308171

genes like me logo Genes that share expression patterns with SFSWAP: view

Protein tissue co-expression partners for SFSWAP Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SFSWAP Gene

Orthologs for SFSWAP Gene

This gene was present in the common ancestor of animals.

Orthologs for SFSWAP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SFSWAP 35
  • 87.51 (n)
  • 91.72 (a)
SFSWAP 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SFSWAP 35
  • 86.1 (n)
  • 90.53 (a)
SFSWAP 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sfswap 35
  • 83.67 (n)
  • 88.68 (a)
Sfswap 16
Sfswap 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sfswap 35
  • 82.97 (n)
  • 89.17 (a)
oppossum
(Monodelphis domestica)
Mammalia SFSWAP 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SFSWAP 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SFSWAP 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves SFSWAP 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SFSWAP 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sfswap 35
  • 65.99 (n)
  • 67.75 (a)
Str.16049 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398537 35
zebrafish
(Danio rerio)
Actinopterygii sfswap 35
  • 60.81 (n)
  • 62.9 (a)
zgc56184 35
sfswap 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta su(w[a]) 36
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea swp-1 36
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToOne
Species with no ortholog for SFSWAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SFSWAP Gene

ENSEMBL:
Gene Tree for SFSWAP (if available)
TreeFam:
Gene Tree for SFSWAP (if available)

Paralogs for SFSWAP Gene

(1) SIMAP similar genes for SFSWAP Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SFSWAP: view

No data available for Paralogs for SFSWAP Gene

Variants for SFSWAP Gene

Sequence variations from dbSNP and Humsavar for SFSWAP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs13578 -- 131,725,444(+) GCACG(G/T)CCAGC reference, missense
rs737434 -- 131,736,514(-) TTTTT(A/G)CCTCT intron-variant
rs755437 -- 131,775,757(+) CTTGC(C/T)TTGTC intron-variant
rs874592 -- 131,741,601(+) TGGTT(G/T)TGCCA intron-variant
rs897654 -- 131,757,106(-) TTTAC(A/G)TGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SFSWAP Gene

Variant ID Type Subtype PubMed ID
dgv535e1 CNV Complex 17122850
esv34554 CNV Gain 17911159
nsv899685 CNV Loss 21882294
nsv899691 CNV Gain 21882294
nsv899699 CNV Gain 21882294
nsv818946 CNV Gain 17921354
nsv899701 CNV Loss 21882294
nsv9044 CNV Gain 18304495
nsv826560 CNV Gain 20364138
nsv455803 CNV Gain 19166990
esv2746894 CNV Deletion 23290073
nsv832555 CNV Loss 17160897
esv2751042 CNV Gain 17911159
nsv52992 CNV Insertion 16902084
esv997559 CNV Insertion 20482838
esv1251086 CNV Insertion 17803354
esv2746895 CNV Deletion 23290073

Variation tolerance for SFSWAP Gene

Residual Variation Intolerance Score: 11.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.16; 51.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SFSWAP Gene

HapMap Linkage Disequilibrium report
SFSWAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFSWAP Gene

Disorders for SFSWAP Gene

Relevant External Links for SFSWAP

Genetic Association Database (GAD)
SFSWAP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SFSWAP
genes like me logo Genes that share disorders with SFSWAP: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SFSWAP Gene

Publications for SFSWAP Gene

  1. The mammalian homolog of suppressor-of-white-apricot regulates alternative mRNA splicing of CD45 exon 4 and fibronectin IIICS. (PMID: 8940107) Sarkissian M. … Lafyatis R. (J. Biol. Chem. 1996) 2 67
  2. Essential domains of the PRP21 splicing factor are implicated in the binding to PRP9 and PRP11 proteins and are conserved through evolution. (PMID: 8718683) Rain J.C. … Legrain P. (RNA 1996) 23 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67

Products for SFSWAP Gene

Sources for SFSWAP Gene

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