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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SFRP5 Gene

protein-coding   GIFtS: 56
GCID: GC10M099516

secreted frizzled-related protein 5
 Explore 27 diseases affiliated with
SFRP5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SFRP5    

Aliases
for SFRP5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Secreted Frizzled-Related Protein 51 2     SARP-32 3
SARP31 2 3 5     SFRP-51
Frizzled-Related Protein 1b2 3     Secreted Apoptosis Related Protein 32
Secreted Apoptosis-Related Protein 32 3     FRP1B3
FRP-1b2 3     

External Ids:    HGNC: 107791   Entrez Gene: 64252   Ensembl: ENSG000001200577   OMIM: 6041585   UniProtKB: Q5T4F73   

Export aliases for SFRP5 gene to outside databases

Previous GC identifers: GC10M098419 GC10M098760 GC10M099657 GC10M099190 GC10M099184 GC10M093151


Summaries
for SFRP5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SFRP5:
Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain
homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling.
SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly
expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SFRP5_HUMAN, Q5T4F7
Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction
with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be
involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina

Gene Wiki entry for SFRP5


Genomic Views
for SFRP5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SFRP5 gene promoter:
         Lmo2   Nkx2-5   Tal-1beta   GATA-1   E47   HFH-1   ITF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SFRP5 promoter sequence
   Search SABiosciences Chromatin IP Primers for SFRP5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SFRP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.1   Ensembl cytogenetic band:  10q24.2   HGNC cytogenetic band: 10q24

SFRP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SFRP5 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M099516:  view genomic region     (about GC identifiers)

Start:
 99,526,508 bp from pter      End:
 99,531,756 bp from pter
Size:
 5,249 bases      Orientation:
 minus strand

Proteins
for SFRP5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SFRP5_HUMAN, Q5T4F7 (See protein sequence)
Recommended Name: Secreted frizzled-related protein 5 precursor  
Size: 317 amino acids; 35563 Da
Subcellular location: Secreted (By similarity)
Secondary accessions: O14780 Q86TH7

Explore the universe of human proteins at neXtProt for SFRP5: NX_Q5T4F7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5T4F7

    • SFRP5 Protein expression data from MOPED and PaxDb:    About this image 
    SFRP5 Protein Expression
    REFSEQ proteins: NP_003006.2  
    ENSEMBL proteins: 
     ENSP00000266066  

    Human Recombinant Protein Products for SFRP5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for SFRP5 (sFRP-5)
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: SFRP5
    OriGene Custom Protein Services for SFRP5 
    GenScript Custom Purified and Recombinant Proteins Services for SFRP5
    Novus Biologicals SFRP5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SFRP5

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS10072424
    GO:0005737cytoplasm IBA--
    GO:0005886plasma membrane IBA--
    GO:0042995NOT cell projection IKR--

    SFRP5 for ontologies           About GeneDecksing



    SFRP5 Antibody Products: 
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    Abcam antibodies for SFRP5 
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    ThermoFisher Antibodies for SFRP5

    Assay Products for SFRP5: 
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    Uscn ELISAs and CLIAs for SFRP5

    Protein Domains /
    Families
    for SFRP5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SFRP5 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR008993 TIMP-like_OB-fold
     IPR015526 Frizzled/SFRP
     IPR020067 Frizzled_dom
     IPR026561 SFRP5
     IPR001134 Netrin_domain

    Graphical View of Domain Structure for InterPro Entry Q5T4F7

    ProtoNet protein and cluster: Q5T4F7

    UniProtKB/Swiss-Prot: SFRP5_HUMAN, Q5T4F7
    Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)
    Similarity: Belongs to the secreted frizzled-related protein (sFRP) family
    Similarity: Contains 1 FZ (frizzled) domain
    Similarity: Contains 1 NTR domain


    Function
    for SFRP5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SFRP5_HUMAN, Q5T4F7
    Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction
    with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be
    involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina

         Genatlas biochemistry entry for SFRP5:
    Drosophila frizzled polarity homolog,secreted related protein 5,mouse sfrp 5 homolog,likely involved in WNT binding and
    signal transduction,expressed in the retinal epithelium and pancreas

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0017147Wnt-protein binding IBA--
    GO:0030165PDZ domain binding IBA--
    GO:0042813Wnt-activated receptor activity IBA--
         
    SFRP5 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Sfrp5):
     craniofacial  embryogenesis  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     limbs/digits/tail  mortality/aging  nervous system  normal  reproductive system 

    SFRP5 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for SFRP5: Sfrp5tm1Aksh Sfrp5tm1Shwl
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SFRP5 

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SFRP5
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate SFRP5:
    hsa-miR-124 hsa-miR-1909* hsa-miR-3942-5p hsa-miR-506 hsa-miR-765 hsa-miR-3652
    SwitchGear 3'UTR luciferase reporter plasmid: SFRP5 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SFRP5 (see all 7)
    OriGene shRNA RFP: SFRP5
    OriGene siRNA: SFRP5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SFRP5
    Sirion Biotech Custom design and validation of potent shRNA sequences against SFRP5 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SFRP5
    Sirion Biotech Customized adenovirus for overexpression of SFRP5 
    Sirion Biotech Customized adenovirus for potent knockdown of SFRP5

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFRP5 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFRP5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SFRP5 (NM_003015)
    Sino Biological Human cDNA Clone for SFRP5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SFRP5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFRP5 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SFRP5
    Search LifeMap BioReagents cell lines for SFRP5
    Sirion Biotech Customized stable knockdown cell line services for SFRP5 
    Sirion Biotech Customized inducible knockdown cell line services for SFRP5
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    Sirion Biotech Customized inducible overexpressing cell line services for SFRP5

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFRP5


    Pathways & Interactions
    for SFRP5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Wnt Signaling Pathway
    		Wnt signaling pathway0.30

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for SFRP5):
        Wnt signaling pathway


    SFRP5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SFRP5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/32 Interacting proteins for SFRP5 (Q5T4F73 ENSP000002660664) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFRP2Q96HF13, ENSP000002740634I2D: score=1 STRING: ENSP00000274063
    SFRP1Q8N4743, ENSP000002207724I2D: score=1 STRING: ENSP00000220772
    FZD1ENSP000002879344STRING: ENSP00000287934
    FZD10ENSP000002290304STRING: ENSP00000229030
    FZD2ENSP000003239014STRING: ENSP00000323901
    About this table

    Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001944vasculature development IBA--
    GO:0006915apoptotic process TAS9391078
    GO:0007163establishment or maintenance of cell polarity TAS10072424
    GO:0007165signal transduction TAS10072424
    GO:0007420brain development IBA--

    SFRP5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SFRP5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SFRP5
    Search CenterWatch for drugs/clinical trials and news about SFRP5 

    Transcripts
    for SFRP5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SFRP5 gene: 
    NM_003015.3  

    Unigene Cluster for SFRP5:

    Secreted frizzled-related protein 5
    Hs.279565  [show with all ESTs]
    Unigene Representative Sequence: AF117758
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000266066(uc001kor.4)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SFRP5
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate SFRP5:
    hsa-miR-124 hsa-miR-1909* hsa-miR-3942-5p hsa-miR-506 hsa-miR-765 hsa-miR-3652
    SwitchGear 3'UTR luciferase reporter plasmid: SFRP5 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SFRP5 (see all 7)
    OriGene shRNA RFP: SFRP5
    OriGene siRNA: SFRP5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SFRP5
    Sirion Biotech Custom design and validation of potent shRNA sequences against SFRP5 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFRP5 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFRP5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SFRP5 (NM_003015)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SFRP5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFRP5 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SFRP5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SFRP5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SFRP5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SFRP5

    Additional cDNA sequence: 

    AF017988.1 AF117758.1 BC050435.1 

    2 DOTS entries:

    DT.40122116  DT.100747160 

    24/30 AceView cDNA sequences (see all 30):

    CR596705 BM694123 CD673335 BM663190 BM694939 BC050435 BQ102400 CK819907 
    BM142123 NM_003015 AL538532 BM141715 BF445674 CD518814 BM716341 BM707670 
    BM141982 CK819908 AF117758 BU727948 BM691353 BM686567 BM141830 BM662388 

    GeneLoc Exon Structure


    Expression
    for SFRP5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SFRP5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGGGTTGGG
    SFRP5 Expression
    About this image

    SFRP5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HypoblastExtraembryonic Visceral EndodermAnterior Visceral Endoderm CellsExtraembryonic Tissues, Yolk Sac
    HypoblastExtraembryonic Visceral EndodermDistal Visceral Endoderm CellsExtraembryonic Tissues, Yolk Sac
    AdiposeVisceral White AdiposeVisceral White AdipocytesAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    Embryoid bodies (Generation of adipoc...)
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
    HyStem+BMP4-induced 7SMOO32 cells (HyStem+BMP4 inductio...)Adipose
    TGF?3+BMP7-induced chondrocytes (Chondrogenic HyStem+...)Bone, Cartilage
    HyStem+TGF?3+GDF5-induced E15 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage

    See SFRP5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SFRP5

    SOURCE GeneReport for Unigene cluster: Hs.279565

    UniProtKB/Swiss-Prot: SFRP5_HUMAN, Q5T4F7
    Tissue specificity: Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart,
    liver and muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including SFRP5: 
              Leukemia in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Adipogenesis in human mouse rat

    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SFRP5
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFRP5

    Orthologs
    for SFRP5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SFRP5 gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Sfrp51 , 5 secreted frizzled-related sequence protein 51, 5 91.86(n)1
    96.09(a)1    		   19 (35.93 cM)5
    546121  NM_018780.31  NP_061250.21 
     421979715 
    chicken
    (Gallus gallus)    		 Aves SFRP51 secreted frizzled-related protein 5 77.74(n)
    73.29(a)    		   423838  XM_421707.2  XP_421707.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SFRP56
    		 --
    		 75(a)
    		 1 ↔ 1
    		 3(39103969-39116288)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.218152 Xenopus laevis secreted frizzled-related protein 5 more 77.51(n)    AY164461.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii sfrp51 secreted frizzled-related protein 5 70.75(n)
    67.01(a)    		   117510  NM_131858.1  NP_571933.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y73B6BL.213   -- 38(a)   IV(6396933-6402093)   --


    ENSEMBL Gene Tree for SFRP5 (if available)
    TreeFam Gene Tree for SFRP5 (if available) 

    Paralogs
    for SFRP5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SFRP5 gene
    FZD102  FZD32  FZD82  FZD12  FZD52  FZD22  FZD92  SFRP42  
    SMO2  FZD42  FZD62  SFRP12  FRZB2  FZD72  SFRP22  
    2 SIMAP similar genes for SFRP5 using alignment to 1 protein entry:     SFRP5_HUMAN:
    SFRP1    SFRP2

    SFRP5 for paralogs           About GeneDecksing



    Genomic Variants
    for SFRP5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/139 NCBI SNPs in SFRP5 are shown (see all 139)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1852738491,2
    		--99526008(+) CCCCCA/GGCCAG 1 -- ds50010--------
    rs111893651,2
    		C,F,H--99526085(+) GTGCCC/TGCGGT 1 -- ds500110Minor allele frequency- T:0.11NS EA NA CSA WA 541
    rs115941661,2
    		H--99526129(+) TCGGCC/TTCAGG 1 -- ds50010--------
    rs1512530581,2
    		--99526199(+) CTCCTC/TGGGGA 1 -- ds50010--------
    rs1131511311,2
    		C--99526241(+) GGGAGA/-AAGCT 1 -- ds50012Minor allele frequency- -:0.25CSA 4
    rs1148655781,2
    		F--99526313(+) TTAGCG/AGTCAG 1 -- ds50012Minor allele frequency- A:0.03WA EA 238
    rs1901327671,2
    		--99526337(+) CCCTTA/GCTATG 1 -- ds50010--------
    rs111893661,2
    		C,H--99526461(+) CCCCCC/TACCTC 1 -- ds5001 trp34Minor allele frequency- T:0.00NS EA 408
    rs21853651,2
    		C,F,A,H--99526507(-) AATAAC/TTGGTT 1 -- ds5001 ese325Minor allele frequency- T:0.22NS EA NA WA CSA 2649
    rs1504390311,2
    		--99526587(+) TACCTA/GTGGCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SFRP5 (99526508 - 99531756 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SFRP5: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SFRP5
    DNA2.0 Custom Variant and Variant Library Synthesis for SFRP5

    Disorders / Diseases
    for SFRP5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SFRP5 for disorders           About GeneDecksing

    OMIM gene information: 604158    OMIM disorders: --

    20/27 diseases for SFRP5 (see all 27):    About MalaCards
    retinitis    oral squamous cell carcinoma    clear cell adenocarcinoma    squamous cell carcinoma
    acute lymphoblastic leukemia    chronic lymphocytic leukemia    lymphoblastic leukemia    acute myeloid leukemia
    lymphocytic leukemia    myeloid leukemia    retinal degeneration    multiple myeloma
    leukemia    gastric cancer    endometrial carcinoma    rabies
    oral cancer    myeloma    hepatocellular carcinoma    ovarian cancer

    3 Novoseek disease relationships for SFRP5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastric cancer 29.3 9 19586554 (5)
    cancer 29.2 2 19586554 (1)
    tumors 27.7 1 18356147 (1)

    Human Genome Epidemiology (HuGE) Navigator: SFRP5 (2 documents)

    Export disorders for SFRP5 gene to outside databases

    Publications
    for SFRP5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SFRP5 gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with SFRP5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. SARPs: a family of secreted apoptosis-related proteins. (PubMed id 9391078)1, 2, 3 Melkonyan H.S.... Umansky S.R. (1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    4. Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium. (PubMed id 10072424)1, 2 Chang J.T.... Zack D.J. (1999)
    5. Tissue restricted expression of two human Frzbs in preadipocytes and pancreas. (PubMed id 9642118)1, 2 Hu E....Brooks D. (1998)
    6. Downregulation of SFRP5 expression and its inverse co rrelation with those of MMP-7 and MT1-MMP in gastric cancer. (PubMed id 19586554)1, 9 Zhao C....Wang W. (2009)
    7. Epigenetic inactivation of the secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosis. (PubMed id 18356147)1, 9 Veeck J....Dahl E. (2008)
    8. Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling. (PubMed id 18981481)1, 9 Li Y....Zorn A.M. (2008)
    9. Pro-inflammatory wnt5a and anti-inflammatory sFRP5 are differentially regulated by nutritional factors in obese human subjects. (PubMed id 22384249)1 Schulte D.M....Laudes M. (2012)
    10. Decreased expression and aberrant hypermethylation of the SFRP genes in human gastric cancer. (PubMed id 21830441)1 Kinoshita T....Nakao A. (2011)

    External Searches for SFRP5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SFRP5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6425 HGNC: 10779 AceView: SFRP5 Ensembl:ENSG00000120057 euGenes: HUgn6425
    ECgene: SFRP5 Kegg: 6425 H-InvDB: SFRP5

    Other Databases showing SFRP5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SFRP5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SFRP5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SFRP5 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SFRP5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SFRP5 gene:
    Search GeneIP for patents involving SFRP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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