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SFRP5 Gene

protein-coding   GIFtS: 56
GCID: GC10M099516

Secreted Frizzled-Related Protein 5

  Search for SFRP5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Secreted Frizzled-Related Protein 51 2     FRP-1b2 3
SARP32 3 5     SARP-32 3
Secreted Apoptosis Related Protein 31 2     sFRP-52 3
Frizzled-Related Protein 1b2 3     FRP1B3
Secreted Apoptosis-Related Protein 32 3     

External Ids:    HGNC: 107791   Entrez Gene: 64252   Ensembl: ENSG000001200577   OMIM: 6041585   UniProtKB: Q5T4F73   

Export aliases for SFRP5 gene to outside databases

Previous GC identifers: GC10M098419 GC10M098760 GC10M099657 GC10M099190 GC10M099184 GC10M093151


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SFRP5 Gene:
Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain
homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt
signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina.
SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. (provided
by RefSeq, Jul 2008)

GeneCards Summary for SFRP5 Gene:
SFRP5 (secreted frizzled-related protein 5) is a protein-coding gene. GO annotations related to this gene include Wnt-activated receptor activity and PDZ domain binding. An important paralog of this gene is FZD3.

UniProtKB/Swiss-Prot: SFRP5_HUMAN, Q5T4F7
Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct
interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types.
SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina

Gene Wiki entry for SFRP5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the SFRP5 gene promoter:
         Lmo2   Nkx2-5   Tal-1beta   GATA-1   E47   HFH-1   ITF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSFRP5 promoter sequence
   Search Chromatin IP Primers for SFRP5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SFRP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.1   Ensembl cytogenetic band:  10q24.2   HGNC cytogenetic band: 10q24

SFRP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SFRP5 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M099516:  view genomic region     (about GC identifiers)

Start:
99,526,508 bp from pter      End:
99,531,756 bp from pter
Size:
5,249 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SFRP5_HUMAN, Q5T4F7 (See protein sequence)
Recommended Name: Secreted frizzled-related protein 5 precursor  
Size: 317 amino acids; 35563 Da
Secondary accessions: O14780 Q86TH7

Explore the universe of human proteins at neXtProt for SFRP5: NX_Q5T4F7

Explore proteomics data for SFRP5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SFRP5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003006.2  
    ENSEMBL proteins: 
     ENSP00000266066  

    SFRP5 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SFRP5
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    Novus Biologicals SFRP5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SFRP5

     
    Search eBioscience for Proteins for SFRP5 

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    LSBio Antibodies in human, mouse, rat for SFRP5

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    Cloud-Clone Corp. CLIAs for SFRP5
    Search eBioscience for ELISAs for SFRP5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SFRP: Secreted frizzled-related proteins

    Selected InterPro protein domains (see all 6):
     IPR008993 TIMP-like_OB-fold
     IPR020067 Frizzled_dom
     IPR026559 SFRP1/5
     IPR015526 Frizzled/SFRP
     IPR001134 Netrin_domain

    Graphical View of Domain Structure for InterPro Entry Q5T4F7

    ProtoNet protein and cluster: Q5T4F7

    UniProtKB/Swiss-Prot: SFRP5_HUMAN, Q5T4F7
    Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)
    Similarity: Belongs to the secreted frizzled-related protein (sFRP) family
    Similarity: Contains 1 FZ (frizzled) domain
    Similarity: Contains 1 NTR domain


    Find genes that share domains with SFRP5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SFRP5_HUMAN, Q5T4F7
    Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct
    interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types.
    SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina

         Genatlas biochemistry entry for SFRP5:
    Drosophila frizzled polarity homolog,secreted related protein 5,mouse sfrp 5 homolog,likely involved in WNT
    binding and signal transduction,expressed in the retinal epithelium and pancreas

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0017147Wnt-protein binding IBA--
    GO:0030165PDZ domain binding IBA--
    GO:0042813Wnt-activated receptor activity IBA--
         
    Find genes that share ontologies with SFRP5           About GenesLikeMe


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Sfrp5):
     craniofacial  embryogenesis  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 
     limbs/digits/tail  mortality/aging  nervous system  normal  reproductive system 

    Find genes that share phenotypes with SFRP5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SFRP5: Sfrp5tm1Aksh Sfrp5tm1Shwl

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SFRP5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SFRP5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SFRP5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SFRP5

    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate SFRP5:
    hsa-miR-124 hsa-miR-1909* hsa-miR-3942-5p hsa-miR-506 hsa-miR-765 hsa-miR-3652
    SwitchGear 3'UTR luciferase reporter plasmidSFRP5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SFRP5

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SFRP5 (NM_003015)
    Sino Biological Human cDNA Clone for SFRP5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SFRP5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFRP5

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFRP5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SFRP5_HUMAN, Q5T4F7: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    plasma membrane3
    nucleus2
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS10072424
    GO:0005737cytoplasm IBA--
    GO:0005886plasma membrane IBA--
    GO:0042995NOT cell projection IKR--

    Find genes that share ontologies with SFRP5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SFRP5 About    
    See pathways by source

    SuperPathContained pathways About
    1Non-Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    2Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40


    Find genes that share SuperPaths with SFRP5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Sino Biological Pathway for SFRP5
        Non-Canonical Wnt Pathway


    1 Kegg Pathway  (Kegg details for SFRP5):
        Wnt signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SFRP5: 
              Leukemia in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Adipogenesis in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SFRP5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SFRP5 (Q5T4F73 ENSP000002660664) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFRP1Q8N4743, ENSP000002207724I2D: score=1 STRING: ENSP00000220772
    SFRP2Q96HF13, ENSP000002740634I2D: score=1 STRING: ENSP00000274063
    FZD1ENSP000002879344STRING: ENSP00000287934
    FZD10ENSP000002290304STRING: ENSP00000229030
    FZD2ENSP000003239014STRING: ENSP00000323901
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001944vasculature development IBA--
    GO:0006915apoptotic process TAS9391078
    GO:0007163establishment or maintenance of cell polarity TAS10072424
    GO:0007165signal transduction TAS10072424
    GO:0007420brain development IBA--

    Find genes that share ontologies with SFRP5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SFRP5

    1 PharmGKB related drug/compound annotation for SFRP5 gene    About this table
    Drug/compound PharmGKB Annotation
    BisphosphonatesCA  



    Find genes that share compounds with SFRP5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SFRP5 gene: 
    NM_003015.3  

    Unigene Cluster for SFRP5:

    Secreted frizzled-related protein 5
    Hs.279565  [show with all ESTs]
    Unigene Representative Sequence: AF117758
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000266066(uc001kor.4)
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate SFRP5:
    hsa-miR-124 hsa-miR-1909* hsa-miR-3942-5p hsa-miR-506 hsa-miR-765 hsa-miR-3652
    SwitchGear 3'UTR luciferase reporter plasmidSFRP5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SFRP5
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    OriGene ORF clones in mouse, rat for SFRP5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SFRP5 (NM_003015)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SFRP5
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SFRP5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SFRP5
      QuantiTect SYBR Green Assays in human, mouse, rat SFRP5
      QuantiFast Probe-based Assays in human, mouse, rat SFRP5

    Additional mRNA sequence: 

    AF017988.1 AF117758.1 BC050435.1 

    2 DOTS entries:

    DT.40122116  DT.100747160 

    Selected AceView cDNA sequences (see all 30):

    CD673335 BM694939 CR596705 BM694123 BM663190 BQ102400 AF117758 BM141982 
    BU727948 CK819908 CD518814 CK819907 BC050435 BM716341 BM707670 AL538532 
    BF445674 BM141715 NM_003015 BM142123 BM685364 BM686567 AF017988 BQ879095 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SFRP5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGGTTGGG
    SFRP5 Expression
    About this image


    SFRP5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             TGFbeta3+BMP7-induced chondrocytes
     
     Cartilage (Muscoskeletal System)    fully expand to see all 5 entries
             TGFbeta3+BMP7-induced chondrocytes
     
     Adipose (Muscoskeletal System)    fully expand to see all 3 entries
             Visceral White Adipocytes Visceral White Adipose
             HyStem+BMP4-induced E15 cells
     
     Hypoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Anterior Visceral Endoderm Cells Extraembryonic Visceral Endoderm
     
     Yolk Sac (Extraembryonic Tissues)    fully expand to see all 2 entries
             Anterior Visceral Endoderm Cells Extraembryonic Visceral Endoderm
    SFRP5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SFRP5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.279565

    UniProtKB/Swiss-Prot: SFRP5_HUMAN, Q5T4F7
    Tissue specificity: Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in
    heart, liver and muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SFRP5: 
              Leukemia in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Adipogenesis in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFRP5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SFRP5 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sfrp51 , 5 secreted frizzled-related sequence protein 51, 5 92.01(n)1
    96.23(a)1
      19 (35.93 cM)5
    546121  NM_018780.31  NP_061250.21 
     421979715 
    chicken
    (Gallus gallus)
    Aves SFRP51 secreted frizzled-related protein 5 78.78(n)
    74.39(a)
      423838  XM_421707.3  XP_421707.1 
    lizard
    (Anolis carolinensis)
    Reptilia SFRP56
    secreted frizzled-related protein 5
    74(a)
    1 ↔ 1
    3(39103762-39116306)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.218152 Xenopus laevis secreted frizzled-related protein 5 more 77.51(n)    AY164461.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sfrp51 secreted frizzled-related protein 5 72.12(n)
    67.97(a)
      117510  NM_131858.1  NP_571933.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y73B6BL.213   -- 38(a)   IV(6396933-6402093)   --


    ENSEMBL Gene Tree for SFRP5 (if available)
    TreeFam Gene Tree for SFRP5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SFRP5 gene
    FZD32  FZD102  FZD82  FZD12  FZD52  FZD22  FZD92  SFRP42  
    SMO2  FZD42  FZD62  SFRP12  FRZB2  FZD72  SFRP22  
    2 SIMAP similar genes for SFRP5 using alignment to 1 protein entry:     SFRP5_HUMAN:
    SFRP1    SFRP2

    Find genes that share paralogs with SFRP5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SFRP5 (see all 175)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1852738491,2
    --99526008(+) CCCCCA/GGCCAG 1 -- ds50010--------
    rs111893651,2
    C,F,H--99526085(+) GTGCCC/TGCGGT 1 -- ds500110Minor allele frequency- T:0.11NS EA NA CSA WA 541
    rs115941661,2
    H--99526129(+) TCGGCC/TTCAGG 1 -- ds50010--------
    rs1512530581,2
    --99526199(+) CTCCTC/TGGGGA 1 -- ds50010--------
    rs57872541,2
    C--99526242(+) GAGAAA/-GCTGG 1 -- ds50012Minor allele frequency- -:0.25CSA 4
    rs1148655781,2
    C,F--99526313(+) TTAGCG/AGTCAG 1 -- ds50012Minor allele frequency- A:0.03WA EA 238
    rs1901327671,2
    --99526337(+) CCCTTA/GCTATG 1 -- ds50010--------
    rs111893661,2
    C,H--99526461(+) CCCCCC/TACCTC 1 -- ds5001 trp34Minor allele frequency- T:0.00NS EA 408
    rs21853651,2
    C,F,A,H--99526507(-) AATAAC/TTGGTT 1 -- ds5001 ese325Minor allele frequency- T:0.22NS EA NA WA CSA 2649
    rs1504390311,2
    --99526587(+) TACCTA/GTGGCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SFRP5 (99526508 - 99531756 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SFRP5: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SFRP5
    DNA2.0 Custom Variant and Variant Library Synthesis for SFRP5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604158    OMIM disorders: --


    Find genes that share disorders with SFRP5           About GenesLikeMe

    3 Novoseek inferred disease relationships for SFRP5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastric cancer 29.3 9 19586554 (5)
    cancer 29.2 2 19586554 (1)
    tumors 27.7 1 18356147 (1)

    Genetic Association Database (GAD): SFRP5
    Human Genome Epidemiology (HuGE) Navigator: SFRP5 (2 documents)

    Export disorders for SFRP5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SFRP5 gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with SFRP5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SARPs: a family of secreted apoptosis-related proteins. (PubMed id 9391078)1, 2, 3 Melkonyan H.S.... Umansky S.R. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    2. A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma. (PubMed id 19926868)1, 4 Sharma S....Weiss S.T. (Am. J. Respir. Crit. Care Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    5. Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium. (PubMed id 10072424)1, 2 Chang J.T.... Zack D.J. (Hum. Mol. Genet. 1999)
    6. Tissue restricted expression of two human Frzbs in preadipocytes and pancreas. (PubMed id 9642118)1, 2 Hu E....Brooks D. (Biochem. Biophys. Res. Commun. 1998)
    7. Downregulation of SFRP5 expression and its inverse correlation with those of MMP-7 and MT1-MMP in gastric cancer. (PubMed id 19586554)1, 9 Zhao C....Wang W. (BMC Cancer 2009)
    8. Epigenetic inactivation of the secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosis. (PubMed id 18356147)1, 9 Veeck J....Dahl E. (Carcinogenesis 2008)
    9. Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling. (PubMed id 18981481)1, 9 Li Y....Zorn A.M. (amp 2008)
    10. SFRP5 inhibits gastric epithelial cell migration induced by macrophage-derived Wnt5a. (PubMed id 23054609)1 Zhao C....Zhang N. (Carcinogenesis 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6425 HGNC: 10779 AceView: SFRP5 Ensembl:ENSG00000120057 euGenes: HUgn6425
    ECgene: SFRP5 Kegg: 6425 H-InvDB: SFRP5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SFRP5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SFRP5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SFRP5 gene:
    Search GeneIP for patents involving SFRP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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