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Aliases for SFRP5 Gene

Aliases for SFRP5 Gene

  • Secreted Frizzled Related Protein 5 2 3 5
  • Secreted Apoptosis Related Protein 3 2 3
  • Frizzled-Related Protein 1b 3 4
  • FRP-1b 3 4
  • SARP-3 3 4
  • SFRP-5 3 4
  • SARP3 3 4
  • Secreted Apoptosis-Related Protein 3 4
  • Secreted Frizzled-Related Protein 5 3
  • FRP1B 4

External Ids for SFRP5 Gene

Previous GeneCards Identifiers for SFRP5 Gene

  • GC10M098419
  • GC10M098760
  • GC10M099657
  • GC10M099190
  • GC10M099184
  • GC10M099516
  • GC10M093151

Summaries for SFRP5 Gene

Entrez Gene Summary for SFRP5 Gene

  • Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. [provided by RefSeq, Jul 2008]

GeneCards Summary for SFRP5 Gene

SFRP5 (Secreted Frizzled Related Protein 5) is a Protein Coding gene. Diseases associated with SFRP5 include Esophageal Basaloid Squamous Cell Carcinoma. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling and Wnt Signaling Pathway and Pluripotency. GO annotations related to this gene include G-protein coupled receptor activity and Wnt-protein binding. An important paralog of this gene is SFRP1.

UniProtKB/Swiss-Prot for SFRP5 Gene

  • Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.

Gene Wiki entry for SFRP5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFRP5 Gene

Genomics for SFRP5 Gene

Regulatory Elements for SFRP5 Gene

Enhancers for SFRP5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F097792 0.2 ENCODE 11.7 -20.2 -20160 0.2 CTCF KLF17 ZIC2 RAD21 ZNF335 GLIS2 PATZ1 ZNF143 SMC3 STAT1 SFRP5 CRTAC1 PIR33458
GH10F097742 0.2 ENCODE 11.7 +28.3 28311 1.7 PKNOX1 CBX3 ESRRA TAL1 POLR2A NCOR1 NR2F6 ZNF600 MTA2 NR2F1 MARVELD1 HOGA1 SFRP5 PI4K2A ENSG00000249967 C10orf62 ZFYVE27
GH10F097796 0.8 Ensembl ENCODE 11.6 -24.7 -24685 0.9 RFX1 STAT1 CBFB JUNB USF2 GABPA ZNF121 RAD51 NFYB SFRP5 CRTAC1 PIR33458
GH10F097861 1 Ensembl ENCODE 11.6 -89.8 -89778 1.2 PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 SFRP5 SLIT1-AS1 ZFYVE27 GOLGA7B PIR47260
GH10F097862 0.2 Ensembl 11.6 -90.7 -90702 0.2 SFRP5 GOLGA7B PIR47260
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SFRP5 on UCSC Golden Path with GeneCards custom track

Promoters for SFRP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001763310 -1 401 CTCF KLF1 SUZ12 TAL1 ZIC2 CCNT2 ZFHX2 GLIS2 NCOR1 ZNF366

Genomic Location for SFRP5 Gene

Chromosome:
10
Start:
97,766,751 bp from pter
End:
97,771,999 bp from pter
Size:
5,249 bases
Orientation:
Minus strand

Genomic View for SFRP5 Gene

Genes around SFRP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFRP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFRP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFRP5 Gene

Proteins for SFRP5 Gene

  • Protein details for SFRP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T4F7-SFRP5_HUMAN
    Recommended name:
    Secreted frizzled-related protein 5
    Protein Accession:
    Q5T4F7
    Secondary Accessions:
    • O14780
    • Q86TH7

    Protein attributes for SFRP5 Gene

    Size:
    317 amino acids
    Molecular mass:
    35563 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SFRP5 Gene

Post-translational modifications for SFRP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SFRP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for SFRP5
  • Santa Cruz Biotechnology (SCBT) Antibodies for SFRP5

No data available for DME Specific Peptides for SFRP5 Gene

Domains & Families for SFRP5 Gene

Gene Families for SFRP5 Gene

Suggested Antigen Peptide Sequences for SFRP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T4F7

UniProtKB/Swiss-Prot:

SFRP5_HUMAN :
  • The FZ domain is involved in binding with Wnt ligands.
  • Belongs to the secreted frizzled-related protein (sFRP) family.
Domain:
  • The FZ domain is involved in binding with Wnt ligands.
  • Contains 1 FZ (frizzled) domain.
  • Contains 1 NTR domain.
Family:
  • Belongs to the secreted frizzled-related protein (sFRP) family.
genes like me logo Genes that share domains with SFRP5: view

Function for SFRP5 Gene

Molecular function for SFRP5 Gene

GENATLAS Biochemistry:
Drosophila frizzled polarity homolog,secreted related protein 5,mouse sfrp 5 homolog,likely involved in WNT binding and signal transduction,expressed in the retinal epithelium and pancreas
UniProtKB/Swiss-Prot Function:
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.

Gene Ontology (GO) - Molecular Function for SFRP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0017147 Wnt-protein binding NAS 24431302
GO:0042813 Wnt-activated receptor activity IBA --
genes like me logo Genes that share ontologies with SFRP5: view
genes like me logo Genes that share phenotypes with SFRP5: view

Animal Models for SFRP5 Gene

MGI Knock Outs for SFRP5:

Animal Model Products

  • Taconic Biosciences Mouse Models for SFRP5

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SFRP5 Gene

Localization for SFRP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFRP5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SFRP5 Gene COMPARTMENTS Subcellular localization image for SFRP5 gene
Compartment Confidence
extracellular 5
nucleus 3
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for SFRP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS 10072424
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with SFRP5: view

Pathways & Interactions for SFRP5 Gene

genes like me logo Genes that share pathways with SFRP5: view

Pathways by source for SFRP5 Gene

1 KEGG pathway for SFRP5 Gene

Gene Ontology (GO) - Biological Process for SFRP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 9391078
GO:0007163 establishment or maintenance of cell polarity TAS 10072424
GO:0007165 signal transduction TAS 10072424
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with SFRP5: view

No data available for SIGNOR curated interactions for SFRP5 Gene

Drugs & Compounds for SFRP5 Gene

(1) Drugs for SFRP5 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bisphosphonates Pharma 0
genes like me logo Genes that share compounds with SFRP5: view

Transcripts for SFRP5 Gene

mRNA/cDNA for SFRP5 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(30) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SFRP5 Gene

Secreted frizzled-related protein 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SFRP5 Gene

No ASD Table

Relevant External Links for SFRP5 Gene

GeneLoc Exon Structure for
SFRP5
ECgene alternative splicing isoforms for
SFRP5

Expression for SFRP5 Gene

mRNA expression in normal human tissues for SFRP5 Gene

mRNA differential expression in normal tissues according to GTEx for SFRP5 Gene

This gene is overexpressed in Nerve - Tibial (x18.7), Pancreas (x10.7), and Heart - Atrial Appendage (x6.7).

Protein differential expression in normal tissues from HIPED for SFRP5 Gene

This gene is overexpressed in Islet of Langerhans (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SFRP5 Gene



Protein tissue co-expression partners for SFRP5 Gene

NURSA nuclear receptor signaling pathways regulating expression of SFRP5 Gene:

SFRP5

SOURCE GeneReport for Unigene cluster for SFRP5 Gene:

Hs.279565

mRNA Expression by UniProt/SwissProt for SFRP5 Gene:

Q5T4F7-SFRP5_HUMAN
Tissue specificity: Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart, liver and muscle.
genes like me logo Genes that share expression patterns with SFRP5: view

Primer Products

Orthologs for SFRP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SFRP5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SFRP5 34 35
  • 95.09 (n)
dog
(Canis familiaris)
Mammalia SFRP5 34 35
  • 94.2 (n)
mouse
(Mus musculus)
Mammalia Sfrp5 34 16 35
  • 92.01 (n)
rat
(Rattus norvegicus)
Mammalia Sfrp5 34
  • 91.08 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SFRP5 35
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SFRP5 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves SFRP5 34 35
  • 78.78 (n)
lizard
(Anolis carolinensis)
Reptilia SFRP5 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sfrp5 34
  • 69.82 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21815 34
zebrafish
(Danio rerio)
Actinopterygii sfrp5 34 35
  • 72.12 (n)
worm
(Caenorhabditis elegans)
Secernentea Y73B6BL.21 36
  • 38 (a)
sfrp-1 35
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8698 35
  • 37 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5649 34
Species where no ortholog for SFRP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SFRP5 Gene

ENSEMBL:
Gene Tree for SFRP5 (if available)
TreeFam:
Gene Tree for SFRP5 (if available)

Paralogs for SFRP5 Gene

Paralogs for SFRP5 Gene

(2) SIMAP similar genes for SFRP5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SFRP5: view

Variants for SFRP5 Gene

Sequence variations from dbSNP and Humsavar for SFRP5 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs111331060 -- 97,767,717(+) GCCCG(C/T)GCCAT reference, missense
rs111783533 -- 97,766,920(+) GCGGA(C/G)CAGAA utr-variant-3-prime
rs11189365 -- 97,766,328(+) GTGCC(C/T)GCGGT downstream-variant-500B
rs11189366 -- 97,766,704(+) CCCCC(C/T)ACCTC downstream-variant-500B
rs11189367 -- 97,771,990(+) GCGGG(C/T)GCCCC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SFRP5 Gene

Variant ID Type Subtype PubMed ID
nsv552026 CNV loss 21841781

Variation tolerance for SFRP5 Gene

Residual Variation Intolerance Score: 67.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SFRP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SFRP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFRP5 Gene

Disorders for SFRP5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SFRP5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
esophageal basaloid squamous cell carcinoma
  • basaloid squamous carcinoma of esophagus
- elite association - COSMIC cancer census association via MalaCards
Search SFRP5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SFRP5

Genetic Association Database (GAD)
SFRP5
Human Genome Epidemiology (HuGE) Navigator
SFRP5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SFRP5
genes like me logo Genes that share disorders with SFRP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SFRP5 Gene

Publications for SFRP5 Gene

  1. SARPs: a family of secreted apoptosis-related proteins. (PMID: 9391078) Melkonyan H.S. … Umansky S.R. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 64
  2. A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma. (PMID: 19926868) Sharma S. … Weiss S.T. (Am. J. Respir. Crit. Care Med. 2010) 3 46 64
  3. Downregulation of SFRP5 expression and its inverse correlation with those of MMP-7 and MT1-MMP in gastric cancer. (PMID: 19586554) Zhao C. … Wang W. (BMC Cancer 2009) 3 22 64
  4. Epigenetic inactivation of the secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosis. (PMID: 18356147) Veeck J. … Dahl E. (Carcinogenesis 2008) 3 22 64
  5. Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling. (PMID: 18981481) Li Y. … Zorn A.M. (Genes Dev. 2008) 3 22 64

Products for SFRP5 Gene

Sources for SFRP5 Gene

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