Aliases for SFRP4 Gene
External Ids for SFRP4 Gene
Previous GeneCards Identifiers for SFRP4 Gene
Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008]
GeneCards Summary for SFRP4 Gene
SFRP4 (Secreted Frizzled-Related Protein 4) is a Protein Coding gene. Diseases associated with SFRP4 include hypophosphatemic rickets, autosomal dominant and oncogenic osteomalacia. Among its related pathways are Adipogenesis and Wnt signaling pathway (KEGG). GO annotations related to this gene include PDZ domain binding and Wnt-activated receptor activity. An important paralog of this gene is FZD10.
UniProtKB/Swiss-Prot for SFRP4 Gene
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.