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Aliases for SFRP4 Gene

Aliases for SFRP4 Gene

  • Secreted Frizzled-Related Protein 4 2 3
  • FRPHE 3 4 6
  • Frizzled Protein, Human Endometrium 3 4
  • SFRP-4 3 4
  • Secreted Frizzled-Related Protein 4; Secreted Frizzled-Related Protein 4 3
  • FRP-4 3

External Ids for SFRP4 Gene

Summaries for SFRP4 Gene

Entrez Gene Summary for SFRP4 Gene

  • Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008]

GeneCards Summary for SFRP4 Gene

SFRP4 (Secreted Frizzled-Related Protein 4) is a Protein Coding gene. Diseases associated with SFRP4 include hypophosphatemic rickets, autosomal dominant and oncogenic osteomalacia. Among its related pathways are Adipogenesis and Wnt signaling pathway (KEGG). GO annotations related to this gene include PDZ domain binding and Wnt-activated receptor activity. An important paralog of this gene is FZD10.

UniProtKB/Swiss-Prot for SFRP4 Gene

  • Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.

Gene Wiki entry for SFRP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFRP4 Gene

Genomics for SFRP4 Gene

Genomic Location for SFRP4 Gene

Start:
37,905,932 bp from pter
End:
38,025,695 bp from pter
Size:
119,764 bases
Orientation:
Minus strand

Genomic View for SFRP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SFRP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFRP4 Gene

Regulatory Elements for SFRP4 Gene

Proteins for SFRP4 Gene

  • Protein details for SFRP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6FHJ7-SFRP4_HUMAN
    Recommended name:
    Secreted frizzled-related protein 4
    Protein Accession:
    Q6FHJ7
    Secondary Accessions:
    • B4DYC1
    • O14877
    • Q05BG7
    • Q1ZYW2
    • Q4G124
    • Q6FHM0
    • Q6PD64

    Protein attributes for SFRP4 Gene

    Size:
    346 amino acids
    Molecular mass:
    39827 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAG63683.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SFRP4 Gene

Proteomics data for SFRP4 Gene at MOPED

Post-translational modifications for SFRP4 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn38, Asn68, Asn116, Asn194, and Asn240

Other Protein References for SFRP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SFRP4 Gene

Domains for SFRP4 Gene

Gene Families for SFRP4 Gene

HGNC:
  • SFRP :Secreted frizzled-related proteins

Protein Domains for SFRP4 Gene

Suggested Antigen Peptide Sequences for SFRP4 Gene

Graphical View of Domain Structure for InterPro Entry

Q6FHJ7

UniProtKB/Swiss-Prot:

SFRP4_HUMAN
Domain:
  • The FZ domain is involved in binding with Wnt ligands.:
    • Q6FHJ7
  • Contains 1 FZ (frizzled) domain.:
    • Q6FHJ7
  • Contains 1 NTR domain.:
    • Q6FHJ7
Family:
  • Belongs to the secreted frizzled-related protein (sFRP) family.:
    • Q6FHJ7
genes like me logo Genes that share domains with SFRP4: view

Function for SFRP4 Gene

Molecular function for SFRP4 Gene

GENATLAS Biochemistry: Drosophila frizzled polarity homolog,secreted related protein 4,mouse sfrp 4 homolog,likely involved in WNT binding and signal transduction
UniProtKB/Swiss-Prot Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.
UniProtKB/Swiss-Prot Induction: Increased levels in failing myocardium. Up-regulated in several tumor types including ostomalacia-associated tumors and endometrial and breast carcinomas

Gene Ontology (GO) - Molecular Function for SFRP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 NOT G-protein coupled receptor activity IBA --
GO:0005515 protein binding IPI 15607035
GO:0017147 Wnt-protein binding IBA --
GO:0030165 PDZ domain binding --
GO:0042813 NOT Wnt-activated receptor activity IBA --
genes like me logo Genes that share ontologies with SFRP4: view
genes like me logo Genes that share phenotypes with SFRP4: view

miRNA for SFRP4 Gene

miRTarBase miRNAs that target SFRP4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SFRP4 Gene

Localization for SFRP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFRP4 Gene

Secreted. Note=Cytoplasmic in ovarian tumor cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SFRP4 Gene COMPARTMENTS Subcellular localization image for SFRP4 gene
Compartment Confidence
extracellular 5
nucleus 4
plasma membrane 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SFRP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IDA 14760084
GO:0005634 nucleus IDA 18938133
GO:0005737 cytoplasm IDA 11793365
GO:0009986 cell surface IDA 14760084
genes like me logo Genes that share ontologies with SFRP4: view

Pathways for SFRP4 Gene

genes like me logo Genes that share pathways with SFRP4: view

Pathways by source for SFRP4 Gene

2 Sino Biological pathways for SFRP4 Gene
2 BioSystems pathways for SFRP4 Gene
1 KEGG pathway for SFRP4 Gene

Gene Ontology (GO) - Biological Process for SFRP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001944 vasculature development --
GO:0002092 positive regulation of receptor internalization IDA 16151791
GO:0007275 multicellular organismal development IEA --
GO:0007420 brain development --
GO:0008285 negative regulation of cell proliferation IMP 14760084
genes like me logo Genes that share ontologies with SFRP4: view

Compounds for SFRP4 Gene

(1) HMDB Compounds for SFRP4 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5

(4) Novoseek inferred chemical compound relationships for SFRP4 Gene

Compound -log(P) Hits PubMed IDs
25-hydroxyvitamin d 51.4 4
calcitriol 44.4 1
progesterone 18 3
calcium 0 2
genes like me logo Genes that share compounds with SFRP4: view

Transcripts for SFRP4 Gene

mRNA/cDNA for SFRP4 Gene

Unigene Clusters for SFRP4 Gene

Secreted frizzled-related protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SFRP4 Gene

No ASD Table

Relevant External Links for SFRP4 Gene

GeneLoc Exon Structure for
SFRP4
ECgene alternative splicing isoforms for
SFRP4

Expression for SFRP4 Gene

mRNA expression in normal human tissues for SFRP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SFRP4 Gene

This gene is overexpressed in Cervix - Endocervix (10.8), Nerve - Tibial (6.4), Uterus (5.8), and Cervix - Ectocervix (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SFRP4 Gene

SOURCE GeneReport for Unigene cluster for SFRP4 Gene Hs.658169

mRNA Expression by UniProt/SwissProt for SFRP4 Gene

Q6FHJ7-SFRP4_HUMAN
Tissue specificity: Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level).
genes like me logo Genes that share expressions with SFRP4: view

Orthologs for SFRP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SFRP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SFRP4 35
  • 99.71 (n)
  • 99.71 (a)
SFRP4 36
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SFRP4 35
  • 91.71 (n)
  • 95.95 (a)
SFRP4 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SFRP4 35
  • 91.81 (n)
  • 94.8 (a)
SFRP4 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sfrp4 35
  • 88.31 (n)
  • 93.62 (a)
Sfrp4 16
Sfrp4 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SFRP4 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SFRP4 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sfrp4 35
  • 88.41 (n)
  • 92.73 (a)
chicken
(Gallus gallus)
Aves SFRP4 35
  • 73.23 (n)
  • 70 (a)
SFRP4 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SFRP4 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sfrp4 35
  • 69.04 (n)
  • 69.14 (a)
zebrafish
(Danio rerio)
Actinopterygii FP102169.1 36
  • 19 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta fz4 36
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mig-1 36
  • 12 (a)
OneToMany
Species with no ortholog for SFRP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SFRP4 Gene

ENSEMBL:
Gene Tree for SFRP4 (if available)
TreeFam:
Gene Tree for SFRP4 (if available)

Paralogs for SFRP4 Gene

Paralogs for SFRP4 Gene

Selected SIMAP similar genes for SFRP4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SFRP4: view

Variants for SFRP4 Gene

Sequence variations from dbSNP and Humsavar for SFRP4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1052969 -- 37,906,945(-) TGTGA(C/T)GAAAG utr-variant-3-prime
rs1052974 -- 37,906,938(-) AAAGG(G/T)GATTT utr-variant-3-prime
rs1052981 -- 37,906,899(-) GAAAA(C/T)TATAA utr-variant-3-prime
rs1132552 -- 37,914,238(-) GCAAC(A/G)TATCT synonymous-codon, reference
rs1132553 -- 37,912,124(-) TGGCG(C/T)TCAAG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for SFRP4 Gene

Variant ID Type Subtype PubMed ID
nsv8074 CNV Loss 18304495

Relevant External Links for SFRP4 Gene

HapMap Linkage Disequilibrium report
SFRP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFRP4 Gene

Disorders for SFRP4 Gene

(2) University of Copenhagen DISEASES for SFRP4 Gene

(12) Novoseek inferred disease relationships for SFRP4 Gene

Disease -log(P) Hits PubMed IDs
hypophosphatemic rickets, autosomal dominant 85.4 1
rickets hypophosphatemic 84.6 1
osteomalacia 82.5 7
hypophosphatemia 82.4 7
hyperphosphatemia 54 2

Relevant External Links for SFRP4

Genetic Association Database (GAD)
SFRP4
Human Genome Epidemiology (HuGE) Navigator
SFRP4
genes like me logo Genes that share disorders with SFRP4: view

No data available for UniProtKB/Swiss-Prot for SFRP4 Gene

Publications for SFRP4 Gene

  1. Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy. (PMID: 10211996) Abu-Jawdeh G.M. … Kocher O. (Lab. Invest. 1999) 2 3 4 23
  2. Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent. (PMID: 12952927) Berndt T. … Kumar R. (J. Clin. Invest. 2003) 3 4 23
  3. Expression of secreted frizzled-related protein 4 (SFRP4) in primary serous ovarian tumours. (PMID: 19480240) Drake J. … Dharmarajan A. (Eur. J. Gynaecol. Oncol. 2009) 3 4 23
  4. Wnt antagonist gene polymorphisms and renal cancer. (PMID: 19562778) Hirata H. … Dahiya R. (Cancer 2009) 3 23 48
  5. The roles of Wnt antagonists Dkk1 and sFRP4 during adipogenesis of human adipose tissue-derived mesenchymal stem cells. (PMID: 19040566) Park J.R. … Kang K.S. (Cell Prolif. 2008) 3 23

Products for SFRP4 Gene

Sources for SFRP4 Gene

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