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SFRP4 Gene

protein-coding   GIFtS: 64
GCID: GC07M037912

Secreted Frizzled-Related Protein 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Secreted Frizzled-Related Protein 41 2     FRP-42
FRPHE2 3 5     Secreted Frizzled-Related Protein 4; Secreted Frizzled-Related Protein 42
Frizzled Protein, Human Endometrium2 3     FrpHE3
sFRP-42 3     

External Ids:    HGNC: 107781   Entrez Gene: 64242   Ensembl: ENSG000001064837   OMIM: 6065705   UniProtKB: Q6FHJ73   

Export aliases for SFRP4 gene to outside databases

Previous GC identifers: GC07M037591 GC07M037686 GC07M037652 GC07M037718


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SFRP4 Gene:
Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain
homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt
signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression.
(provided by RefSeq, Jul 2008)

GeneCards Summary for SFRP4 Gene:
SFRP4 (secreted frizzled-related protein 4) is a protein-coding gene. Diseases associated with SFRP4 include hypophosphatemic rickets, autosomal dominant, and hereditary hypophosphatemic rickets. GO annotations related to this gene include Wnt-activated receptor activity and PDZ domain binding. An important paralog of this gene is FZD3.

UniProtKB/Swiss-Prot: SFRP4_HUMAN, Q6FHJ7
Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct
interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types.
SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation
possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically
inhibiting sodium-dependent phosphate uptake

Gene Wiki entry for SFRP4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the SFRP4 gene promoter:
         CRE-BP1   AREB6   p53   ATF-2   Nkx2-5   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSFRP4 promoter sequence
   Search Chromatin IP Primers for SFRP4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SFRP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.1   Ensembl cytogenetic band:  7p14.1   HGNC cytogenetic band: 7p14.1

SFRP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SFRP4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M037912:  view genomic region     (about GC identifiers)

Start:
37,945,534 bp from pter      End:
38,065,297 bp from pter
Size:
119,764 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 37,983,430-37,994,420     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SFRP4_HUMAN, Q6FHJ7 (See protein sequence)
Recommended Name: Secreted frizzled-related protein 4 precursor  
Size: 346 amino acids; 39827 Da
Sequence caution: Sequence=BAG63683.1; Type=Erroneous initiation;
Secondary accessions: B4DYC1 O14877 Q05BG7 Q1ZYW2 Q4G124 Q6FHM0 Q6PD64

Explore the universe of human proteins at neXtProt for SFRP4: NX_Q6FHJ7

Explore proteomics data for SFRP4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn38, Asn68, Asn116, Asn194, Asn240
  • Modification sites at PhosphoSitePlus

  • See SFRP4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003005.2  
    ENSEMBL proteins: 
     ENSP00000410715   ENSP00000402262  

    SFRP4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for SFRP4 (sFRP-4)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for SFRP4
    OriGene Protein Over-expression Lysate for SFRP4
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SFRP4
    GenScript Custom Purified and Recombinant Proteins Services for SFRP4
    Novus Biologicals SFRP4 Protein
    Novus Biologicals SFRP4 Lysates
    Sino Biological Recombinant Protein for SFRP4
    Sino Biological Cell Lysate for SFRP4
    ProSpec Recombinant Protein for SFRP4
    Cloud-Clone Corp. Proteins for SFRP4

    SFRP4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SFRP4
    R&D Systems Antibodies for SFRP4 (sFRP-4)
    OriGene Antibodies for SFRP4
    OriGene Custom Antibody Services for SFRP4
    Novus Biologicals SFRP4 Antibodies
    Abcam antibodies for SFRP4
    Cloud-Clone Corp. Antibodies for SFRP4
    ThermoFisher Antibodies for SFRP4
    LSBio Antibodies in human, mouse, rat for SFRP4

    SFRP4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SFRP4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SFRP4
    Cloud-Clone Corp. CLIAs for SFRP4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SFRP: Secreted frizzled-related proteins

    Selected InterPro protein domains (see all 6):
     IPR008993 TIMP-like_OB-fold
     IPR020067 Frizzled_dom
     IPR026560 SFRP4
     IPR015526 Frizzled/SFRP
     IPR001134 Netrin_domain

    Graphical View of Domain Structure for InterPro Entry Q6FHJ7

    ProtoNet protein and cluster: Q6FHJ7

    UniProtKB/Swiss-Prot: SFRP4_HUMAN, Q6FHJ7
    Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)
    Similarity: Belongs to the secreted frizzled-related protein (sFRP) family
    Similarity: Contains 1 FZ (frizzled) domain
    Similarity: Contains 1 NTR domain


    SFRP4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SFRP4_HUMAN, Q6FHJ7
    Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct
    interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types.
    SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation
    possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically
    inhibiting sodium-dependent phosphate uptake
    Induction: Increased levels in failing myocardium. Up-regulated in several tumor types including
    ostomalacia-associated tumors and endometrial and breast carcinomas

         Genatlas biochemistry entry for SFRP4:
    Drosophila frizzled polarity homolog,secreted related protein 4,mouse sfrp 4 homolog,likely involved in WNT
    binding and signal transduction

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0017147Wnt-protein binding IBA--
    GO:0030165PDZ domain binding IBA--
    GO:0042813Wnt-activated receptor activity IBA--
         
    SFRP4 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sfrp4):
     cardiovascular system  digestive/alimentary  growth/size/body  homeostasis/metabolism  mortality/aging 
     renal/urinary system  reproductive system  respiratory system 

    SFRP4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SFRP4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SFRP4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SFRP4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SFRP4

    miRNA
    Products:
        
    miRTarBase miRNAs that target SFRP4:
    hsa-mir-26b-5p (MIRT030345)

    Block miRNA regulation of human, mouse, rat SFRP4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SFRP4 (see all 19):
    hsa-miR-576-3p hsa-miR-181c hsa-miR-346 hsa-miR-2276 hsa-miR-3143 hsa-miR-23a hsa-miR-181b hsa-miR-34c-3p
    SwitchGear 3'UTR luciferase reporter plasmidSFRP4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SFRP4
    Predesigned siRNA for gene silencing in human, mouse, rat SFRP4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SFRP4

    Clone
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    OriGene clones in human, mouse for SFRP4 (see all 6)
    OriGene ORF clones in mouse, rat for SFRP4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SFRP4 (NM_003014)
    Sino Biological Human cDNA Clone for SFRP4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SFRP4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFRP4

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SFRP4
    Browse ESI BIO Cell Lines and PureStem Progenitors for SFRP4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFRP4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SFRP4_HUMAN, Q6FHJ7: Secreted. Note=Cytoplasmic in ovarian tumor cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus4
    plasma membrane2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IDA14760084
    GO:0005634nucleus IDA18938133
    GO:0005737cytoplasm IDA11793365
    GO:0009986cell surface IDA14760084

    SFRP4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SFRP4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Non-Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    Canonical Wnt Pathway0.53
    2Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway0.55
    3Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    4Adipogenesis
    Adipogenesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for SFRP4
        Wnt Signaling Pathway
    Adipogenesis

    2 Sino Biological Pathways for SFRP4
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway


    1 Kegg Pathway  (Kegg details for SFRP4):
        Wnt signaling pathway


    SFRP4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SFRP4: 
              Leukemia in human mouse rat
              WNT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SFRP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SFRP4 (Q6FHJ73 ENSP000004107154) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WNT3AP567043, ENSP000002845234I2D: score=1 STRING: ENSP00000284523
    GABARAPO951663I2D: score=1 
    FZD1ENSP000002879344STRING: ENSP00000287934
    FZD10ENSP000002290304STRING: ENSP00000229030
    FZD2ENSP000003239014STRING: ENSP00000323901
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001944vasculature development IBA--
    GO:0002092positive regulation of receptor internalization IDA16151791
    GO:0007409NOT axonogenesis IRD--
    GO:0007420brain development IBA--
    GO:0008285negative regulation of cell proliferation IMP14760084

    SFRP4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SFRP4

    1 HMDB Compound for SFRP4    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    4 Novoseek inferred chemical compound relationships for SFRP4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    25-hydroxyvitamin d 51.4 6 12952927 (1), 14675031 (1), 16151791 (1), 17002592 (1)
    calcitriol 44.4 1 19352177 (1)
    progesterone 18 4 12021176 (1), 18287870 (1), 15239838 (1)
    calcium 0 6 19387319 (1), 15607035 (1)



    SFRP4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SFRP4 gene: 
    NM_003014.3  

    Unigene Cluster for SFRP4:

    Secreted frizzled-related protein 4
    Hs.658169  [show with all ESTs]
    Unigene Representative Sequence: NM_003014
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000436072(uc003tfo.4) ENST00000478975 ENST00000447200
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SFRP4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SFRP4 (see all 19):
    hsa-miR-576-3p hsa-miR-181c hsa-miR-346 hsa-miR-2276 hsa-miR-3143 hsa-miR-23a hsa-miR-181b hsa-miR-34c-3p
    SwitchGear 3'UTR luciferase reporter plasmidSFRP4 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SFRP4
    Predesigned siRNA for gene silencing in human, mouse, rat SFRP4
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SFRP4 (NM_003014)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SFRP4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFRP4
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SFRP4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SFRP4
      QuantiTect SYBR Green Assays in human, mouse, rat SFRP4
      QuantiFast Probe-based Assays in human, mouse, rat SFRP4

    Additional mRNA sequence: 

    AF026692.1 AK302357.1 AK303977.1 AK313029.1 BC032828.1 BC047684.1 BC058911.1 BT019679.1 
    CR541731.1 CR541755.1 DQ420628.1 

    6 DOTS entries:

    DT.313601  DT.101980568  DT.100012323  DT.95269438  DT.100793630  DT.92437916 

    Selected AceView cDNA sequences (see all 167):

    CB215544 CA448824 BM998617 BI835131 CB215895 AI537091 BQ955420 AW089415 
    CB215059 CB215470 BU631139 AW966766 CB215487 AA993238 CB215013 CB215074 
    BQ881195 CA394545 AA487193 CB215457 CA395959 CB215739 BU738996 BM832895 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SFRP4 expression in normal human tissues (normalized intensities)      SFRP4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCCCTTGC
    SFRP4 Expression
    About this image


    SFRP4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Granulosa Cells Primary Follicle
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    SFRP4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SFRP4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.658169

    UniProtKB/Swiss-Prot: SFRP4_HUMAN, Q6FHJ7
    Tissue specificity: Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium.
    Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as
    the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of
    CTNNB1 (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SFRP4: 
              Leukemia in human mouse rat
              WNT Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SFRP4
    OriGene qSTAR qPCR primer pairs in human, mouse for SFRP4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SFRP4
    QuantiTect SYBR Green Assays in human, mouse, rat SFRP4
    QuantiFast Probe-based Assays in human, mouse, rat SFRP4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFRP4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for SFRP4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sfrp41 , 5 secreted frizzled-related protein 41, 5 88.31(n)1
    93.62(a)1
      13 (6.99 cM)5
    203791  NM_016687.31  NP_057896.11 
     196231755 
    chicken
    (Gallus gallus)
    Aves SFRP41 secreted frizzled-related protein 4 73.23(n)
    70(a)
      420732  XM_418831.4  XP_418831.4 
    lizard
    (Anolis carolinensis)
    Reptilia SFRP46
    secreted frizzled-related protein 4
    63(a)
    1 ↔ 1
    6(47778949-47788666)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sfrp41 secreted frizzled-related protein 4 69.04(n)
    69.14(a)
      100492736  XM_002939421.2  XP_002939467.2 
    zebrafish
    (Danio rerio)
    Actinopterygii FP102169.16
    Uncharacterized protein
    19(a)
    many ↔ many
    23(6870778-6877165) ENSDARG00000089210
    fruit fly
    (Drosophila melanogaster)
    Insecta fz46
    frizzled 4
    11(a)
    1 → many
    X(7000305-7004325)
    worm
    (Caenorhabditis elegans)
    Secernentea mig-16
    Protein MIG-1, isoform a (mig-1) mRNA, complete cd...
    12(a)
    1 → many
    I(948566-957373) WBGene00003238


    ENSEMBL Gene Tree for SFRP4 (if available)
    TreeFam Gene Tree for SFRP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SFRP4 gene
    FZD32  FZD102  FZD82  FZD12  FZD52  FZD22  FZD92  SMO2  
    FZD42  FZD62  SFRP12  FRZB2  SFRP52  FZD72  SFRP22  
    1 SIMAP similar gene for SFRP4 using alignment to 2 protein entries:     SFRP4_HUMAN (see all proteins):
    FRZB

    SFRP4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SFRP4 (see all 338)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58836191,2
    C--37835597(+) TTCAG-/A/AA  
            
    AAAAA
    1 -- int1 trp31NA 2
    rs715581031,2
    C--37945037(+) ATCTG-/TCTA/ 
    TCTATCTA
    TCTAT
    1 -- ds50011NA 2
    rs1494745251,2
    --37945037(+) ATCTG-/TCTAT 
     CTATCTA
    TCTAT
    1 -- ds50010--------
    rs2003768781,2
    C--37945037(+) ATCTG-/TCTA  
            
    TCTAT
    1 -- ds50010--------
    rs715466091,2
    C--37945058(+) TCTATG/CTATCT 1 -- ds50011Minor allele frequency- C:0.50NA 2
    rs1465493571,2
    C--37945066(+) TCTATC/GTATCT 1 -- ds50010--------
    rs2017924801,2
    --37945098(+) CTATC-/TATCTA 1 -- ds50010--------
    rs127015991,2
    C,F--37945103(+) TATCTG/ATCTGT 1 -- ds50013Minor allele frequency- A:0.33NA WA 6
    rs1893705721,2
    --37945123(+) TGTCTA/GTCTAT 1 -- ds50010--------
    rs1484227771,2
    C--37945135(+) CATCC-/ATCT  
            
    ATCTT
    1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SFRP4 (37945534 - 38065297 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SFRP4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv8074CNV Loss18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SFRP4
    DNA2.0 Custom Variant and Variant Library Synthesis for SFRP4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606570    OMIM disorders: --

    Selected diseases for SFRP4 (see all 38):    About MalaCards
    hypophosphatemic rickets, autosomal dominant    hereditary hypophosphatemic rickets    familial chronic lymphocytic leukemia    oncogenic osteomalacia
    osteomalacia    hypophosphatemia    hyperphosphatemia    rickets
    ureteral obstruction    endometrial stromal sarcoma    ectopic pregnancy    paraneoplastic syndromes
    chronic lymphocytic leukemia    barrett's esophagus    uterine fibroid    pituitary tumors
    oral cancer    multiple myeloma    endometriosis    myeloma

    2 diseases from the University of Copenhagen DISEASES database for SFRP4:
    Hypophosphatemia     Osteomalacia

    SFRP4 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for SFRP4 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypophosphatemic rickets, autosomal dominant 85.4 2 18288501 (1)
    rickets hypophosphatemic 84.6 2 18288501 (1)
    osteomalacia 82.5 10 12187320 (2), 12952927 (1), 18288501 (1), 14730508 (1) (see all 6)
    hypophosphatemia 82.4 13 16691036 (2), 12952927 (1), 16151791 (1), 18288501 (1) (see all 6)
    hyperphosphatemia 54 3 16691036 (2)
    rickets 39.4 1 12187320 (1)
    mesothelioma 28.8 4 15705870 (4)
    tumors 20.8 8 19000546 (1), 12952927 (1), 18287870 (1), 12187320 (1) (see all 6)
    renal disease 5.49 2 16691036 (2)
    renal failure chronic 0 3 16691036 (2)

    Genetic Association Database (GAD): SFRP4
    Human Genome Epidemiology (HuGE) Navigator: SFRP4 (7 documents)

    Export disorders for SFRP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SFRP4 gene, integrated from 10 sources (see all 90):
    (articles sorted by number of sources associating them with SFRP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy. (PubMed id 10211996)1, 2, 3, 9 Abu-Jawdeh G.M.... Kocher O. (Lab. Invest. 1999)
    2. Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent. (PubMed id 12952927)1, 2, 9 Berndt T.... Kumar R. (J. Clin. Invest. 2003)
    3. Expression of secreted frizzled-related protein 4 (SFRP4) in primary serous ovarian tumours. (PubMed id 19480240)1, 2, 9 Drake J....Dharmarajan A. (Eur. J. Gynaecol. Oncol. 2009)
    4. Wnt antagonist gene polymorphisms and renal cancer. (PubMed id 19562778)1, 4, 9 Hirata H....Dahiya R. (Cancer 2009)
    5. Association between polymorphisms in Wnt signaling pathway genes and bone mineral density in postmenopausal Korean women. (PubMed id 20613673)1, 4 Lee D.Y....Kim J.G. (Menopause 2010)
    6. Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer. (PubMed id 20403915)1, 4 Frank B....Brenner H. (Carcinogenesis 2010)
    7. A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. (PubMed id 19396169)1, 4 Cho Y.S....Kim H.L. (Nat. Genet. 2009)
    8. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Expression of secreted frizzled related proteins 3 and 4 in human ventricular myocardium correlates with apoptosis related gene expression. (PubMed id 10728394)1, 2 Schumann H.... Hatzfeld M. (Cardiovasc. Res. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6424 HGNC: 10778 AceView: SFRP4 Ensembl:ENSG00000106483 euGenes: HUgn6424
    ECgene: SFRP4 Kegg: 6424 H-InvDB: SFRP4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SFRP4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SFRP4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SFRP4 gene:
    Search GeneIP for patents involving SFRP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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