Aliases for SFRP4 Gene
External Ids for SFRP4 Gene
Previous GeneCards Identifiers for SFRP4 Gene
Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008]
GeneCards Summary for SFRP4 Gene
SFRP4 (Secreted Frizzled Related Protein 4) is a Protein Coding gene. Diseases associated with SFRP4 include hypophosphatemic rickets, autosomal dominant and oncogenic osteomalacia. Among its related pathways are Wnt signaling pathway (KEGG) and Wnt Signaling Pathways: beta-Catenin-independent Wnt/PCP Signaling Pathways. GO annotations related to this gene include G-protein coupled receptor activity and Wnt-protein binding. An important paralog of this gene is FZD10.
UniProtKB/Swiss-Prot for SFRP4 Gene
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.