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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SFRP2 Gene

protein-coding GIFtS: 63
GCID: GC04M154701

secreted frizzled-related protein 2

Explore 45 diseases affiliated with
SFRP2 via

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our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Secreted Frizzled-Related Protein 2¹ ²		SARP-1² ³
SARP1¹ ² ³ ⁵		SFRP-2¹
FRP-2¹ ² ³		Secreted Apoptosis Related Protein 1²
SDF-5¹ ²		FRP2³
Secreted Apoptosis-Related Protein 1² ³

External Ids:	HGNC: 10777¹	Entrez Gene: 6423²	Ensembl: ENSG00000145423⁷	OMIM: 604157⁵	UniProtKB: Q96HF1³

Export aliases for SFRP2 gene to outside databases

Previous GC identifers: GC04M155550 GC04M155090 GC04M155279 GC04M155059 GC04M154921 GC04M150432

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SFRP2:

This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative

Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a

potential marker for the presence of colorectal cancer. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SFRP2_HUMAN, Q96HF1

Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction

with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be

important for eye retinal development and for myogenesis

Gene Wiki entry for SFRP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SFRP2 gene promoter:
FOXF2 MAZR Brachyury Pax-2 Pax-2a C/EBPalpha CREB CHOP-10 deltaCREB ZIC2/Zic2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SFRP2 promoter sequence

Search SABiosciences Chromatin IP Primers for SFRP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SFRP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.3 Ensembl cytogenetic band: 4q31.3 HGNC cytogenetic band: 4q31.3

SFRP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SFRP2 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M154701: view genomic region (about GC identifiers)

Start:	154,701,742 bp from pter	End:	154,710,272 bp from pter
Size:	8,531 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SFRP2_HUMAN, Q96HF1 (See protein sequence)

Recommended Name: Secreted frizzled-related protein 2 precursor

Size: 295 amino acids; 33490 Da

Subcellular location: Secreted (By similarity)

Secondary accessions: B3KQR2 O14778 Q9HAP5

Explore the universe of human proteins at neXtProt for SFRP2: NX_Q96HF1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96HF1

SFRP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003004.1

ENSEMBL proteins:

ENSP00000274063

Human Recombinant Protein Products for SFRP2:

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	Novus Biologicals SFRP2 Lysate
	Sino Biological Recombinant Protein for SFRP2
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SFRP2

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	ISS	--
GO:0005737	cytoplasm	IBA	--
GO:0005886	plasma membrane	IBA	--
GO:0031012	extracellular matrix	ISS	--
GO:0042995	NOT cell projection	IKR	--

SFRP2 for ontologies About GeneDecksing

SFRP2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of SFRP2
	R&D Systems Antibodies for SFRP2 (sFRP-2)
	OriGene Antibodies (see all 2): SFRP2 OriGene Custom Antibody Services for SFRP2
	GenScript Custom Superior Antibodies Services for SFRP2
	Novus Biologicals SFRP2 Antibodies
	Abcam antibodies for SFRP2
	Uscn Antibodies for SFRP2
	ThermoFisher Antibodies for SFRP2

Assay Products for SFRP2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for SFRP2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SFRP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SFRP2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR008993 TIMP-like_OB-fold

IPR015526 Frizzled/SFRP

IPR020067 Frizzled_dom

IPR001134 Netrin_domain

IPR026558 SFRP2

Graphical View of Domain Structure for InterPro Entry Q96HF1

ProtoNet protein and cluster: Q96HF1

UniProtKB/Swiss-Prot: SFRP2_HUMAN, Q96HF1

Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)

Similarity: Belongs to the secreted frizzled-related protein (sFRP) family

Similarity: Contains 1 FZ (frizzled) domain

Similarity: Contains 1 NTR domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SFRP2_HUMAN, Q96HF1

Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction

with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be

important for eye retinal development and for myogenesis

Genatlas biochemistry entry for SFRP2:

Drosophila frizzled polarity homolog,secreted related protein 2,mouse sfrp 2 homolog,likely involved in WNT binding and

signal transduction,expressed in inner nuclear layer of the retina

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001968	fibronectin binding	ISS	--
GO:0005178	integrin binding	ISS	--
GO:0005515	protein binding	--	--
GO:0010577	metalloenzyme activator activity	IEA	--
GO:0017147	Wnt-protein binding	IBA	--

SFRP2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for SFRP2:

Decreased DCP1a protein expres

15/19 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Sfrp2) (see all 19):

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial
embryogenesis	endocrine/exocrine gland	growth/size	homeostasis/metabolism	limbs/digits/tail
mortality/aging	muscle	nervous system	no phenotypic analysis	normal

SFRP2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for SFRP2: Sfrp2^tm1Nat Sfrp2^tm1Aksh Sfrp2^tm1Ktas Sfrp2^tm1.1Brle

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SFRP2

miRNA Products:		miRTarBase miRNAs that target SFRP2: hsa-mir-29a (MIRT003607)

		OriGene 3'-UTR Clone: SFRP2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SFRP2
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate SFRP2 (see all 23):
		hsa-miR-3200-5p hsa-miR-16-2* hsa-miR-300 hsa-miR-3942-5p hsa-miR-606 hsa-miR-218 hsa-miR-570 hsa-miR-510

		SwitchGear 3'UTR luciferase reporter plasmid: SFRP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SFRP2 (see all 7) OriGene shRNA RFP: SFRP2 OriGene siRNA: SFRP2
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		Sirion Biotech Custom design and validation of potent shRNA sequences against SFRP2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SFRP2
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFRP2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFRP2 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SFRP2 (NM_003013)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SFRP2
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SFRP2
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		Sirion Biotech Customized stable knockdown cell line services for SFRP2 Sirion Biotech Customized inducible knockdown cell line services for SFRP2 Sirion Biotech Customized stable overexpressing cell line services for SFRP2 Sirion Biotech Customized inducible overexpressing cell line services for SFRP2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFRP2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Wnt Signaling Pathway

Wnt signaling pathway

0.30

Wnt Signaling Pathway NetPath

0.22

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for SFRP2

Wnt Signaling Pathway NetPath

1 Kegg Pathway (Kegg details for SFRP2):

Wnt signaling pathway

SFRP2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SFRP2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/39 Interacting proteins for SFRP2 (Q96HF1³ ENSP00000274063⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 39)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
WNT4	P56705³, ENSP00000290167⁴	I2D: score=3 STRING: ENSP00000290167
BARX1	Q9HBU1³, ENSP00000253968⁴	I2D: score=1 STRING: ENSP00000253968
PAX2	Q02962³, ENSP00000355069⁴	I2D: score=1 STRING: ENSP00000355069
SFRP5	Q5T4F7³, ENSP00000266066⁴	I2D: score=1 STRING: ENSP00000266066
VANGL2	Q9ULK5³, ENSP00000357040⁴	I2D: score=1 STRING: ENSP00000357040

About this table

Gene Ontology (GO): 5/70 biological process terms (GO ID links to tree view) (see all 70): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001569	patterning of blood vessels	ISS	--
GO:0001756	somitogenesis	--	--
GO:0001843	neural tube closure	IEA	--
GO:0001944	vasculature development	IBA	--
GO:0002063	chondrocyte development	IEA	--

SFRP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SFRP2
Search CenterWatch for drugs/clinical trials and news about SFRP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SFRP2 gene:

NM_003013.2

Unigene Cluster for SFRP2:

Secreted frizzled-related protein 2

Hs.481022 [show with all ESTs]

Unigene Representative Sequence: NM_003013

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000274063(uc003inv.1)

miRNA Products:		OriGene 3'-UTR Clone: SFRP2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SFRP2
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate SFRP2 (see all 23):
		hsa-miR-3200-5p hsa-miR-16-2* hsa-miR-300 hsa-miR-3942-5p hsa-miR-606 hsa-miR-218 hsa-miR-570 hsa-miR-510

		SwitchGear 3'UTR luciferase reporter plasmid: SFRP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SFRP2 (see all 7) OriGene shRNA RFP: SFRP2 OriGene siRNA: SFRP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SFRP2
		Sirion Biotech Custom design and validation of potent shRNA sequences against SFRP2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFRP2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFRP2 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SFRP2 (NM_003013)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SFRP2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFRP2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SFRP2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SFRP2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SFRP2

Additional cDNA sequence:

AF017986.1 AF311912.1 AK075372.1 AK093922.1 AY359001.1 BC008666.1

13 DOTS entries:

DT.101982412 DT.91690780 DT.447746 DT.121228179 DT.121228186 DT.100028659 DT.100820542 DT.91690819

DT.100028661 DT.95175245 DT.95175247 DT.95175251 DT.121228193

24/292 AceView cDNA sequences (see all 292):

AI337868 AI366084 AA528219 N93894 BQ437742 AW263293 CA437411 C02046

AI280000 AW262130 AA335712 AI950830 CA436109 AI920995 BQ013445 CA425449

AW338230 AI084022 N64004 AI631423 AI584063 AI580689 CA425679 BM680887

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for SFRP2 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4
SP1:
SP2:

ECgene alternative splicing isoforms for SFRP2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SFRP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTTCTTCAA

About this image

SFRP2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

9 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Outflow Tract

Neural Crest Outflow Tract Cells

Neural Crest

Somite

Cervical Mesenchymal Sclerotome

Cervical Sclerotome Cells

Bone, Cartilage, Tendons & Ligaments

Somite

Lumbar Mesenchymal Sclerotome

Lumbar Sclerotome Cells

Bone, Cartilage, Tendons & Ligaments

Somite

Sacral Mesencymal Sclerotome

Sacral Sclerotome Cells

Bone, Cartilage, Tendons & Ligaments

Somite

Thoracic Mesenchymal Sclerotome

Thoracic Sclerotome Cells

Bone, Cartilage, Tendons & Ligaments

Limb

Zeugopod

Mesenchymal Condensate Cells

Bone, Cartilage

Ovary

Brain

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/15 LifeMap Cells (see all 15)

Name

Category

Sclerotome cells (Primary Cell)

Bone, Cartilage, Somite

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

N2/LSB induced-cells (Generation of midbra...)

Dorsal forebrain-like neurons (Generation of midbra...)

Brain

See SFRP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SFRP2

SOURCE GeneReport for Unigene cluster: Hs.481022

UniProtKB/Swiss-Prot: SFRP2_HUMAN, Q96HF1

Tissue specificity: Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis,

ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon

SABiosciences Expression via Pathway-Focused PCR Arrays including SFRP2:

WNT Signaling Targets in human mouse rat

Leukemia in human mouse rat

WNT Signaling Pathway in human mouse rat

Embryonic Stem Cells in human mouse rat

Liver Cancer in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SFRP2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SFRP2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFRP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SFRP2 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SFRP2¹	secreted frizzled-related protein 2	79.84(n) 81.1(a)		395546 NM_204773.1 NP_990104.1
lizard (Anolis carolinensis)	Reptilia	SFRP2⁶	--	78(a)	1 ↔ 1	5(130782072-130794145)
African clawed frog (Xenopus laevis)	Amphibia	sfrp2-prov²	secreted frizzled-related sequence protein 2	80.83(n)		BC044687.1
zebrafish (Danio rerio)	Actinopterygii	sfrp2¹	secreted frizzled-related protein 2	70.96(n) 72.82(a)		566878 NM_001077384.2 NP_001070852.2
worm (Caenorhabditis elegans)	Secernentea	Y73B6BL.21³ sfrp-1¹	Protein SFRP-1¹	35(a)³ 47(n)¹ 41(a)¹		IV(6396933-6402093)³ 177401¹ NM_068576.3¹ NP_500977.2¹

ENSEMBL Gene Tree for SFRP2 (if available)
TreeFam Gene Tree for SFRP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SFRP2 gene

FZD10² FZD3² FZD8² FZD1² FZD5² FZD2² FZD9² SFRP4²

SMO² FZD4² FZD6² SFRP1² FRZB² FZD7² SFRP5²

2 SIMAP similar genes for SFRP2 using alignment to 1 protein entry: SFRP2_HUMAN:

SFRP1 SFRP5

SFRP2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11099911^1,2	C,F,H	--	154701323(+)	`TACTCT/ACCAAA`	1	--	ds500¹		8		NS EA NA WA	660
rs78031334^1,2	F	--	154701364(+)	`TGAGTC/TGGGGA`	1	--	ds500¹		1		EA	120
rs114345132^1,2	F	--	154701365(+)	`GAGTCG/AGGGAA`	1	--	ds500¹		1		WA	118
rs146081333^1,2		--	154701382(+)	`AACATC/TTTTGC`	1	--	ds500¹		0	--	--	--	--
rs140068876^1,2		--	154701404(+)	`TTTTTC/TGGTAT`	1	--	ds500¹		0	--	--	--	--
rs77221794^1,2	F	--	154701427(+)	`GAAATG/AAAAAG`	1	--	ds500¹		1		WA	118
rs189759342^1,2		--	154701486(+)	`TAGCTG/TCAGCT`	1	--	ds500¹		0	--	--	--	--
rs78183709^1,2	C	--	154701673(+)	`GGAAGG/TAAGTG`	1	--	ds500¹		2		CSA WA	119
rs184182644^1,2		--	154701772(+)	`ATATAC/TAAGAA`	1	--	ut3¹		0	--	--	--	--
rs188636599^1,2		--	154701797(+)	`GAAATA/GTTTAC`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SFRP2 (154701742 - 154710272 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SFRP2: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SFRP2 for disorders           About GeneDecksing

OMIM gene information: 604157    OMIM disorders: --

20/45 diseases for SFRP2 (see all 45):    About MalaCards

colorectal cancer retinitis pigmentosa barrett's esophagus oral squamous cell carcinoma

synpolydactyly retinal degeneration squamous cell carcinoma basal cell carcinoma

chronic lymphocytic leukemia acute myeloid leukemia lymphocytic leukemia ulcerative colitis

myeloid leukemia malignant glioma syndactyly renal cell carcinoma

retinitis pituitary tumor multiple myeloma myeloma

10 Novoseek disease relationships for SFRP2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
precancerous lesions	42.3	2	17410438 (2)
myeloma	41.3	5	16030194 (1), 17882284 (1), 16582506 (1)
mammary tumor	40.5	5	16077992 (1), 14999144 (1), 12866949 (1)
retinal degeneration	38.5	2	11192610 (1)
retinitis pigmentosa	35.2	3	10798643 (1), 11192610 (1)
colorectal cancer	32.5	5	16077992 (3), 18203283 (1), 17410438 (1)
tumors	27.8	18	14999144 (4), 19105936 (2), 18203283 (1), 16077992 (1) (see all 9)
cancer	25.2	4	18404682 (2), 15825175 (1), 17848950 (1)
adenoma	20.8	3	17352030 (1), 18203283 (1), 17410438 (1)
colitis ulcerative	13.8	1	17410438 (1)

Human Genome Epidemiology (HuGE) Navigator: SFRP2 (7 documents)

Export disorders for SFRP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SFRP2 gene, integrated from 9 sources (see all 102):
(articles sorted by number of sources associating them with SFRP2)

Utopia: connect your pdf to the dynamic
world of online information

SARPs: a family of secreted apoptosis-related proteins. (PubMed id 9391078)^{1, 2, 3} Melkonyan H.S.... Umansky S.R. (1997)
Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)^{1, 2} Otsuki T....Isogai T. (2005)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Tissue restricted expression of two human Frzbs in preadipocytes and pancreas. (PubMed id 9642118)^{1, 2} Hu E....Brooks D. (1998)
DNA methylation and histone modifications cause silencing of Wnt antagonist gene in human renal cell carcinoma cell lines. (PubMed id 18404682)^{1, 9} Kawamoto K....Dahiya R. (2008)
Frequent epigenetic inactivation of secreted frizzled-related protein 2 (SFRP2) by promoter methylation in human gastric cancer. (PubMed id 17848950)^{1, 9} Cheng Y.Y....Leung W.K. (2007)
Hypermethylation of SFRP2 as a potential marker for stool-based detection of colorectal cancer and precancerous lesions. (PubMed id 17410438)^{1, 9} Huang Z....Wang J. (2007)
The secreted frizzled related protein 2 (SFRP2) gene is a target of the Pax2 transcription factor. (PubMed id 14561758)^{1, 9} Brophy P.D....Dressler G.R. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6423	HGNC: 10777	AceView: SFRP2	Ensembl:ENSG00000145423	euGenes: HUgn6423
ECgene: SFRP2	Kegg: 6423	H-InvDB: SFRP2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SFRP2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SFRP2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SFRP2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SFRP2 gene:
Search GeneIP for patents involving SFRP2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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secreted frizzled-related protein 2

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secreted frizzled-related protein 2

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