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SFRP2 Gene

protein-coding   GIFtS: 63
GCID: GC04M154701

Secreted Frizzled-Related Protein 2

  See SFRP2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Secreted Frizzled-Related Protein 21 2     sFRP-22 3
SARP12 3 5     SDF-52
Secreted Apoptosis-Related Protein 12 3     Secreted Apoptosis Related Protein 12
FRP-22 3     FRP23
SARP-12 3     

External Ids:    HGNC: 107771   Entrez Gene: 64232   Ensembl: ENSG000001454237   OMIM: 6041575   UniProtKB: Q96HF13   

Export aliases for SFRP2 gene to outside databases

Previous GC identifers: GC04M155550 GC04M155090 GC04M155279 GC04M155059 GC04M154921 GC04M150432


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SFRP2 Gene:
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative
Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene
is a potential marker for the presence of colorectal cancer. (provided by RefSeq, Jul 2008)

GeneCards Summary for SFRP2 Gene:
SFRP2 (secreted frizzled-related protein 2) is a protein-coding gene. Diseases associated with SFRP2 include colorectal cancer. GO annotations related to this gene include Wnt-protein binding and integrin binding. An important paralog of this gene is FZD3.

UniProtKB/Swiss-Prot: SFRP2_HUMAN, Q96HF1
Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct
interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types.
SFRP2 may be important for eye retinal development and for myogenesis

Gene Wiki entry for SFRP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the SFRP2 gene promoter:
         FOXF2   MAZR   Brachyury   Pax-2   Pax-2a   C/EBPalpha   CREB   CHOP-10   deltaCREB   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSFRP2 promoter sequence
   Search Chromatin IP Primers for SFRP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SFRP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.3   Ensembl cytogenetic band:  4q31.3   HGNC cytogenetic band: 4q31.3

SFRP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SFRP2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M154701:  view genomic region     (about GC identifiers)

Start:
154,701,742 bp from pter      End:
154,710,272 bp from pter
Size:
8,531 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SFRP2_HUMAN, Q96HF1 (See protein sequence)
Recommended Name: Secreted frizzled-related protein 2 precursor  
Size: 295 amino acids; 33490 Da
Secondary accessions: B3KQR2 O14778 Q9HAP5

Explore the universe of human proteins at neXtProt for SFRP2: NX_Q96HF1

Explore proteomics data for SFRP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SFRP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003004.1  
    ENSEMBL proteins: 
     ENSP00000274063  
    Reactome Protein details: Q96HF1

    SFRP2 Human Recombinant Protein Products:

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    Novus Biologicals SFRP2 Lysate
    Sino Biological Recombinant Protein for SFRP2
    Sino Biological Cell Lysate for SFRP2
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SFRP2

     
    Search eBioscience for Proteins for SFRP2 

     
    antibodies-online proteins for SFRP2 (6 products) 

     
    antibodies-online peptides for SFRP2

    SFRP2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SFRP2
    R&D Systems Antibodies for SFRP2 (sFRP-2)
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    Novus Biologicals SFRP2 Antibodies
    Abcam antibodies for SFRP2
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    antibodies-online antibodies for SFRP2 (36 products) 

    SFRP2 Assay Products:

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    Cloud-Clone Corp. ELISAs for SFRP2
    Cloud-Clone Corp. CLIAs for SFRP2
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    antibodies-online kits for SFRP2 (29 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SFRP: Secreted frizzled-related proteins

    Selected InterPro protein domains (see all 6):
     IPR008993 TIMP-like_OB-fold
     IPR020067 Frizzled_dom
     IPR015526 Frizzled/SFRP
     IPR001134 Netrin_domain
     IPR026558 SFRP2

    Graphical View of Domain Structure for InterPro Entry Q96HF1

    ProtoNet protein and cluster: Q96HF1

    UniProtKB/Swiss-Prot: SFRP2_HUMAN, Q96HF1
    Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)
    Similarity: Belongs to the secreted frizzled-related protein (sFRP) family
    Similarity: Contains 1 FZ (frizzled) domain
    Similarity: Contains 1 NTR domain


    Find genes that share domains with SFRP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SFRP2_HUMAN, Q96HF1
    Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct
    interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types.
    SFRP2 may be important for eye retinal development and for myogenesis

         Genatlas biochemistry entry for SFRP2:
    Drosophila frizzled polarity homolog,secreted related protein 2,mouse sfrp 2 homolog,likely involved in WNT
    binding and signal transduction,expressed in inner nuclear layer of the retina

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001968fibronectin binding ISS--
    GO:0005178integrin binding ISS--
    GO:0005515protein binding ----
    GO:0010577metalloenzyme activator activity IEA--
    GO:0017147Wnt-protein binding IBA--
         
    Find genes that share ontologies with SFRP2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SFRP2:
     Decreased DCP1a protein expres 

         Selected MGI mutant phenotypes (inferred from 7 alleles(MGI details for Sfrp2) (see all 19):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     embryogenesis  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  limbs/digits/tail 
     mortality/aging  muscle  nervous system  no phenotypic analysis  normal 

    Find genes that share phenotypes with SFRP2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SFRP2: Sfrp2tm1Nat Sfrp2tm1Aksh Sfrp2tm1Ktas Sfrp2tm1.1Brle

       genOway: Develop your customized and physiologically relevant rodent model for SFRP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target SFRP2:
    hsa-mir-29a-3p (MIRT003607), hsa-mir-218-5p (MIRT006749)

    Block miRNA regulation of human, mouse, rat SFRP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SFRP2 (see all 23):
    hsa-miR-3200-5p hsa-miR-16-2* hsa-miR-300 hsa-miR-3942-5p hsa-miR-606 hsa-miR-218 hsa-miR-570 hsa-miR-510
    SwitchGear 3'UTR luciferase reporter plasmidSFRP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SFRP2
    Predesigned siRNA for gene silencing in human, mouse, rat SFRP2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SFRP2

    Clone
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    OriGene clones in human, mouse for SFRP2 (see all 8)
    OriGene ORF clones in mouse, rat for SFRP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SFRP2 (NM_003013)
    Sino Biological Human cDNA Clone for SFRP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SFRP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFRP2

    Cell Line
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    ESI BIO PureStem Progenitors for SFRP2: 
    PureStem MEL2, NCr-fac Progenitor, PureStem SK11, NCr-fac & Meso-prx Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFRP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SFRP2_HUMAN, Q96HF1: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3
    nucleus2
    cytosol1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space ISS--
    GO:0005737cytoplasm IBA--
    GO:0005886plasma membrane IBA--
    GO:0031012extracellular matrix ISS--
    GO:0042995NOT cell projection IKR--

    Find genes that share ontologies with SFRP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SFRP2 About    
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    2Non-Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    Canonical Wnt Pathway0.53


    Find genes that share SuperPaths with SFRP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SFRP2
        Wnt Signaling Pathway NetPath

    2 Sino Biological Pathways for SFRP2
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    1 Reactome Pathway for SFRP2
        negative regulation of TCF-dependent signaling by WNT ligand antagonists


    1 Kegg Pathway  (Kegg details for SFRP2):
        Wnt signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SFRP2: 
              WNT Signaling Targets in human mouse rat
              Leukemia in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Liver Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SFRP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SFRP2 (Q96HF13 ENSP000002740634) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WNT4P567053, ENSP000002901674I2D: score=3 STRING: ENSP00000290167
    BARX1Q9HBU13, ENSP000002539684I2D: score=1 STRING: ENSP00000253968
    PAX2Q029623, ENSP000003550694I2D: score=1 STRING: ENSP00000355069
    SFRP5Q5T4F73, ENSP000002660664I2D: score=1 STRING: ENSP00000266066
    TLL1O438973, ENSP000000612404I2D: score=1 STRING: ENSP00000061240
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 68):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001569patterning of blood vessels ISS--
    GO:0001756somitogenesis ----
    GO:0001843neural tube closure IEA--
    GO:0001944vasculature development IBA--
    GO:0002063chondrocyte development IEA--

    Find genes that share ontologies with SFRP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SFRP2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SFRP2 gene: 
    NM_003013.2  

    Unigene Cluster for SFRP2:

    Secreted frizzled-related protein 2
    Hs.481022  [show with all ESTs]
    Unigene Representative Sequence: NM_003013
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000274063(uc003inv.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat SFRP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SFRP2 (see all 23):
    hsa-miR-3200-5p hsa-miR-16-2* hsa-miR-300 hsa-miR-3942-5p hsa-miR-606 hsa-miR-218 hsa-miR-570 hsa-miR-510
    SwitchGear 3'UTR luciferase reporter plasmidSFRP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SFRP2
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    GenScript: all cDNA clones in your preferred vector: SFRP2 (NM_003013)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SFRP2
      QuantiTect SYBR Green Assays in human, mouse, rat SFRP2
      QuantiFast Probe-based Assays in human, mouse, rat SFRP2

    Additional mRNA sequence: 

    AF017986.1 AF311912.1 AK075372.1 AK093922.1 AY359001.1 BC008666.1 

    13 DOTS entries:

    DT.101982412  DT.91690780  DT.447746  DT.121228179  DT.100028659  DT.121228186  DT.100820542  DT.91690819 
    DT.100028661  DT.121228193  DT.95175245  DT.95175247  DT.95175251 

    Selected AceView cDNA sequences (see all 292):

    BQ004290 AA528219 BQ130455 AW305146 AA329099 AW263304 AI445568 AI580689 
    BE677492 AW000789 BQ007953 N64004 BU738555 BM680887 BQ478123 AW029179 
    AI627567 AI818524 CF528639 BM726281 AI920995 AA347786 C02046 AI631423 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SFRP2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
    SP1:                              
    SP2:                              


    ECgene alternative splicing isoforms for SFRP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SFRP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTCTTCAA
    SFRP2 Expression
    About this image


    SFRP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 8 entries
             Mesenchymal Condensate Cells Zeugopod
             Membranous Facial Bones
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Eye (Sensory Organs)    fully expand to see all 5 entries
             Preplacodal Lens Ectoderm Cells Ocular Surface Ectoderm
             Retinal Pigmented Epithelium
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Metencephalon
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 6 entries
             Human embryonic stem cells (family)
     
     Cartilage (Muscoskeletal System)    fully expand to see all 5 entries
             Mesenchymal Condensate Cells Zeugopod
             HyStem+TGFbeta3+GDF5-induced SK11 cells
    SFRP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SFRP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.481022

    UniProtKB/Swiss-Prot: SFRP2_HUMAN, Q96HF1
    Tissue specificity: Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate,
    testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SFRP2: 
              WNT Signaling Targets in human mouse rat
              Leukemia in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Liver Cancer in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat SFRP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFRP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for SFRP2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sfrp21 , 5 secreted frizzled-related protein 21, 5 93.79(n)1
    97.97(a)1
      3 (37.37 cM)5
    203191  NM_009144.21  NP_033170.11 
     837663215 
    chicken
    (Gallus gallus)
    Aves SFRP21 secreted frizzled-related protein 2 79.84(n)
    81.1(a)
      395546  NM_204773.1  NP_990104.1 
    lizard
    (Anolis carolinensis)
    Reptilia SFRP26
    secreted frizzled-related protein 2
    78(a)
    1 ↔ 1
    5(130781876-130796913)
    African clawed frog
    (Xenopus laevis)
    Amphibia sfrp2-prov2 secreted frizzled-related sequence protein 2 80.83(n)    BC044687.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sfrp21 secreted frizzled-related protein 2 70.96(n)
    72.82(a)
      566878  NM_001077384.2  NP_001070852.2 
    worm
    (Caenorhabditis elegans)
    Secernentea Y73B6BL.213
    sfrp-11
    sfrp-11 35(a)3
    47(n)1
    41(a)1
      IV(6396933-6402093)3
    1774011  NM_068576.41  NP_500977.21 


    ENSEMBL Gene Tree for SFRP2 (if available)
    TreeFam Gene Tree for SFRP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SFRP2 gene
    FZD32  FZD102  FZD82  FZD12  FZD52  FZD22  FZD92  SFRP42  
    SMO2  FZD42  FZD62  SFRP12  FRZB2  SFRP52  FZD72  
    2 SIMAP similar genes for SFRP2 using alignment to 1 protein entry:     SFRP2_HUMAN:
    SFRP1    SFRP5

    Find genes that share paralogs with SFRP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SFRP2 (see all 237)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs585825451,2
    C--154489240(+) AATCT-/ATGTTTA 1 -- int11Minor allele frequency- AT:0.00NA 2
    rs110999111,2
    C,F,H--154701323(+) TACTCT/ACCAAA 1 -- ds50018Minor allele frequency- A:0.11NS EA NA WA 660
    rs780313341,2
    C,F--154701364(+) TGAGTC/TGGGGA 1 -- ds50011Minor allele frequency- T:0.02EA 120
    rs1143451321,2
    F--154701365(+) GAGTCG/AGGGAA 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1460813331,2
    C--154701382(+) AACATC/TTTTGC 1 -- ds50010--------
    rs1400688761,2
    C--154701404(+) TTTTTC/TGGTAT 1 -- ds50010--------
    rs772217941,2
    F--154701427(+) GAAATG/AAAAAG 1 -- ds50011Minor allele frequency- A:0.07WA 118
    rs1897593421,2
    --154701486(+) TAGCTG/TCAGCT 1 -- ds50010--------
    rs781837091,2
    C--154701673(+) GGAAGG/TAAGTG 1 -- ds50012Minor allele frequency- T:0.05CSA WA 119
    rs1841826441,2
    C--154701772(+) ATATAC/TAAGAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SFRP2 (154701742 - 154710272 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SFRP2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SFRP2
    DNA2.0 Custom Variant and Variant Library Synthesis for SFRP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604157    OMIM disorders: --

    1 disease for SFRP2:    
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    colorectal cancer


    Find genes that share disorders with SFRP2           About GenesLikeMe

    10 Novoseek inferred disease relationships for SFRP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    precancerous lesions 42.3 2 17410438 (2)
    myeloma 41.3 5 16030194 (1), 17882284 (1), 16582506 (1)
    mammary tumor 40.5 5 16077992 (1), 14999144 (1), 12866949 (1)
    retinal degeneration 38.5 2 11192610 (1)
    retinitis pigmentosa 35.2 3 10798643 (1), 11192610 (1)
    colorectal cancer 32.5 5 16077992 (3), 18203283 (1), 17410438 (1)
    tumors 27.8 18 14999144 (4), 19105936 (2), 18203283 (1), 16077992 (1) (see all 9)
    cancer 25.2 4 18404682 (2), 15825175 (1), 17848950 (1)
    adenoma 20.8 3 17352030 (1), 18203283 (1), 17410438 (1)
    colitis ulcerative 13.8 1 17410438 (1)

    Genetic Association Database (GAD): SFRP2
    Human Genome Epidemiology (HuGE) Navigator: SFRP2 (7 documents)

    Export disorders for SFRP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SFRP2 gene, integrated from 10 sources (see all 107):
    (articles sorted by number of sources associating them with SFRP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SARPs: a family of secreted apoptosis-related proteins. (PubMed id 9391078)1, 2, 3 Melkonyan H.S.... Umansky S.R. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    2. A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma. (PubMed id 19926868)1, 4 Sharma S....Weiss S.T. (Am. J. Respir. Crit. Care Med. 2010)
    3. Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer. (PubMed id 20403915)1, 4 Frank B....Brenner H. (Carcinogenesis 2010)
    4. Gene methylation of SFRP2, P16, DAPK1, HIC1, and MGMT and KRAS mutations in sporadic colorectal cancer. (PubMed id 20682398)1, 4 Pehlivan S....Pehlivan M. (Cancer Genet. Cytogenet. 2010)
    5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    6. Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae. (PubMed id 19389651)1, 4 Smith J.G....Newton-Cheh C. (Heart Rhythm 2009)
    7. Novel genetic variants contributing to left ventricular hypertrophy: the HyperGEN study. (PubMed id 19593212)1, 4 Arnett D.K....Broeckel U. (J. Hypertens. 2009)
    8. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    9. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6423 HGNC: 10777 AceView: SFRP2 Ensembl:ENSG00000145423 euGenes: HUgn6423
    ECgene: SFRP2 Kegg: 6423 H-InvDB: SFRP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SFRP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SFRP2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SFRP2 gene:
    Search GeneIP for patents involving SFRP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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