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Aliases for SFRP2 Gene

Aliases for SFRP2 Gene

  • Secreted Frizzled Related Protein 2 2 3 5
  • SARP-1 3 4
  • SFRP-2 3 4
  • FRP-2 3 4
  • SARP1 3 4
  • Secreted Apoptosis Related Protein 1 3
  • Secreted Apoptosis-Related Protein 1 4
  • Secreted Frizzled-Related Protein 2 3
  • Testicular Tissue Protein Li 170 3
  • SDF-5 3
  • FRP2 4

External Ids for SFRP2 Gene

Previous GeneCards Identifiers for SFRP2 Gene

  • GC04M155550
  • GC04M155090
  • GC04M155279
  • GC04M155059
  • GC04M154921
  • GC04M154701
  • GC04M150432

Summaries for SFRP2 Gene

Entrez Gene Summary for SFRP2 Gene

  • This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for SFRP2 Gene

SFRP2 (Secreted Frizzled Related Protein 2) is a Protein Coding gene. Diseases associated with SFRP2 include Esophageal Basaloid Squamous Cell Carcinoma and Colorectal Cancer. Among its related pathways are Signaling by Wnt and Wnt Signaling Pathway and Pluripotency. GO annotations related to this gene include G-protein coupled receptor activity and PDZ domain binding. An important paralog of this gene is SFRP5.

UniProtKB/Swiss-Prot for SFRP2 Gene

  • Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.

Gene Wiki entry for SFRP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFRP2 Gene

Genomics for SFRP2 Gene

Regulatory Elements for SFRP2 Gene

Enhancers for SFRP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G153787 1.5 FANTOM5 Ensembl ENCODE dbSUPER 2.3 -0.4 -445 4.5 CTCF RAD21 ETS1 POLR2A EZH2 ZNF680 RNF2 CBX2 CHD1 CBX8 TLR2 SFRP2 GC04P153793
GH04G153792 1.3 Ensembl ENCODE dbSUPER 0.7 -3.6 -3626 1.1 CTCF ATF1 TAL1 RBBP5 RAD21 FOSL1 ZNF766 GATA2 POLR2A NR2F6 TLR2 RNF175 GC04P153793 SFRP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SFRP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SFRP2 Gene

Chromosome:
4
Start:
153,780,590 bp from pter
End:
153,789,120 bp from pter
Size:
8,531 bases
Orientation:
Minus strand

Genomic View for SFRP2 Gene

Genes around SFRP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFRP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFRP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFRP2 Gene

Proteins for SFRP2 Gene

  • Protein details for SFRP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HF1-SFRP2_HUMAN
    Recommended name:
    Secreted frizzled-related protein 2
    Protein Accession:
    Q96HF1
    Secondary Accessions:
    • B3KQR2
    • O14778
    • Q9HAP5

    Protein attributes for SFRP2 Gene

    Size:
    295 amino acids
    Molecular mass:
    33490 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SFRP2 Gene

Post-translational modifications for SFRP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SFRP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SFRP2

Protein Products

No data available for DME Specific Peptides for SFRP2 Gene

Domains & Families for SFRP2 Gene

Gene Families for SFRP2 Gene

Suggested Antigen Peptide Sequences for SFRP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96HF1

UniProtKB/Swiss-Prot:

SFRP2_HUMAN :
  • The FZ domain is involved in binding with Wnt ligands.
  • Belongs to the secreted frizzled-related protein (sFRP) family.
Domain:
  • The FZ domain is involved in binding with Wnt ligands.
Family:
  • Belongs to the secreted frizzled-related protein (sFRP) family.
genes like me logo Genes that share domains with SFRP2: view

Function for SFRP2 Gene

Molecular function for SFRP2 Gene

GENATLAS Biochemistry:
Drosophila frizzled polarity homolog,secreted related protein 2,mouse sfrp 2 homolog,likely involved in WNT binding and signal transduction,expressed in inner nuclear layer of the retina
UniProtKB/Swiss-Prot Function:
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.

Gene Ontology (GO) - Molecular Function for SFRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding ISS --
GO:0005178 integrin binding ISS --
GO:0008047 enzyme activator activity IEA --
GO:0017147 Wnt-protein binding NAS 24431302
GO:0048018 receptor agonist activity ISS --
genes like me logo Genes that share ontologies with SFRP2: view
genes like me logo Genes that share phenotypes with SFRP2: view

Animal Models for SFRP2 Gene

MGI Knock Outs for SFRP2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SFRP2

CRISPR Products

miRNA for SFRP2 Gene

miRTarBase miRNAs that target SFRP2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SFRP2 Gene

Localization for SFRP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFRP2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SFRP2 gene
Compartment Confidence
extracellular 5
plasma membrane 3
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SFRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA,ISS --
GO:0031012 extracellular matrix ISS --
genes like me logo Genes that share ontologies with SFRP2: view

Pathways & Interactions for SFRP2 Gene

genes like me logo Genes that share pathways with SFRP2: view

Pathways by source for SFRP2 Gene

Gene Ontology (GO) - Biological Process for SFRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001569 branching involved in blood vessel morphogenesis ISS --
GO:0001756 somitogenesis IEA --
GO:0001843 neural tube closure IEA --
GO:0002063 chondrocyte development IEA --
GO:0003151 outflow tract morphogenesis IMP 19593212
genes like me logo Genes that share ontologies with SFRP2: view

No data available for SIGNOR curated interactions for SFRP2 Gene

Drugs & Compounds for SFRP2 Gene

No Compound Related Data Available

Transcripts for SFRP2 Gene

mRNA/cDNA for SFRP2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(292) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SFRP2 Gene

Secreted frizzled-related protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SFRP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1:
SP2:

Relevant External Links for SFRP2 Gene

GeneLoc Exon Structure for
SFRP2
ECgene alternative splicing isoforms for
SFRP2

Expression for SFRP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SFRP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SFRP2 Gene

This gene is overexpressed in Artery - Tibial (x8.8).

Protein differential expression in normal tissues from HIPED for SFRP2 Gene

This gene is overexpressed in Vitreous humor (39.2), Skin (10.9), and Breast (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SFRP2 Gene



NURSA nuclear receptor signaling pathways regulating expression of SFRP2 Gene:

SFRP2

SOURCE GeneReport for Unigene cluster for SFRP2 Gene:

Hs.481022

mRNA Expression by UniProt/SwissProt for SFRP2 Gene:

Q96HF1-SFRP2_HUMAN
Tissue specificity: Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon.

Evidence on tissue expression from TISSUES for SFRP2 Gene

  • Eye(4.6)
  • Nervous system(3.9)
  • Intestine(3.5)
  • Pancreas(3.3)
  • Gall bladder(2.3)
  • Muscle(2.3)
  • Heart(2.1)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with SFRP2: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SFRP2 Gene

Orthologs for SFRP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SFRP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SFRP2 34 35
  • 99.44 (n)
oppossum
(Monodelphis domestica)
Mammalia SFRP2 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SFRP2 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SFRP2 34 35
  • 95.01 (n)
cow
(Bos Taurus)
Mammalia SFRP2 34 35
  • 94.1 (n)
rat
(Rattus norvegicus)
Mammalia Sfrp2 34
  • 93.9 (n)
mouse
(Mus musculus)
Mammalia Sfrp2 34 16 35
  • 93.79 (n)
chicken
(Gallus gallus)
Aves SFRP2 34 35
  • 79.84 (n)
lizard
(Anolis carolinensis)
Reptilia SFRP2 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sfrp2 34
  • 78.94 (n)
MGC75789 34
African clawed frog
(Xenopus laevis)
Amphibia sfrp2-prov 34
zebrafish
(Danio rerio)
Actinopterygii sfrp2 34 35
  • 70.96 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6215 34
worm
(Caenorhabditis elegans)
Secernentea sfrp-1 34 35
  • 47 (n)
Y73B6BL.21 36
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
OneToOne
Species where no ortholog for SFRP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SFRP2 Gene

ENSEMBL:
Gene Tree for SFRP2 (if available)
TreeFam:
Gene Tree for SFRP2 (if available)

Paralogs for SFRP2 Gene

Paralogs for SFRP2 Gene

(2) SIMAP similar genes for SFRP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SFRP2: view

Variants for SFRP2 Gene

Sequence variations from dbSNP and Humsavar for SFRP2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs770485715 Likely benign 153,781,713(+) TGGTA(C/T)CTCGG reference, missense
rs1000026971 -- 153,784,174(+) TGTTT(C/T)ATGTG intron-variant
rs1000230585 -- 153,790,140(+) GGGGG(C/G)ACCAT nc-transcript-variant, upstream-variant-2KB
rs1000842314 -- 153,785,893(+) CCATT(A/G)TGTCG reference, missense
rs1000868440 -- 153,789,104(+) TTGGC(C/T)TTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SFRP2 Gene

Variant ID Type Subtype PubMed ID
nsv1022081 CNV gain 25217958
nsv595749 CNV gain 21841781

Variation tolerance for SFRP2 Gene

Residual Variation Intolerance Score: 42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.23; 76.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SFRP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SFRP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFRP2 Gene

Disorders for SFRP2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SFRP2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
esophageal basaloid squamous cell carcinoma
  • basaloid squamous carcinoma of esophagus
colorectal cancer
  • colorectal cancer, somatic
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards
Search SFRP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SFRP2

Genetic Association Database (GAD)
SFRP2
Human Genome Epidemiology (HuGE) Navigator
SFRP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SFRP2
genes like me logo Genes that share disorders with SFRP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SFRP2 Gene

Publications for SFRP2 Gene

  1. SARPs: a family of secreted apoptosis-related proteins. (PMID: 9391078) Melkonyan H.S. … Umansky S.R. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 64
  2. A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma. (PMID: 19926868) Sharma S. … Weiss S.T. (Am. J. Respir. Crit. Care Med. 2010) 3 46 64
  3. Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer. (PMID: 20403915) Frank B. … Brenner H. (Carcinogenesis 2010) 3 46 64
  4. Gene methylation of SFRP2, P16, DAPK1, HIC1, and MGMT and KRAS mutations in sporadic colorectal cancer. (PMID: 20682398) Pehlivan S. … Pehlivan M. (Cancer Genet. Cytogenet. 2010) 3 46 64
  5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64

Products for SFRP2 Gene

Sources for SFRP2 Gene

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