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Aliases for SFRP1 Gene

Aliases for SFRP1 Gene

  • Secreted Frizzled-Related Protein 1 2 3 5
  • Secreted Apoptosis-Related Protein 2 3 4
  • SARP-2 3 4
  • SFRP-1 3 4
  • FRP-1 3 4
  • SARP2 3 4
  • FRP1 3 4
  • FRP 3 4
  • FrzA 3

External Ids for SFRP1 Gene

Previous GeneCards Identifiers for SFRP1 Gene

  • GC08M040568
  • GC08M041148
  • GC08M040860
  • GC08M041136
  • GC08M039647
  • GC08M041119

Summaries for SFRP1 Gene

Entrez Gene Summary for SFRP1 Gene

  • This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]

GeneCards Summary for SFRP1 Gene

SFRP1 (Secreted Frizzled-Related Protein 1) is a Protein Coding gene. Diseases associated with SFRP1 include seckel syndrome 1 and cutaneous telangiectasia and cancer syndrome, familial. Among its related pathways are Signaling by GPCR and Wnt Signaling Pathways: beta-Catenin-independent Wnt/PCP Signaling Pathways. GO annotations related to this gene include G-protein coupled receptor activity and heparin binding. An important paralog of this gene is FZD10.

UniProtKB/Swiss-Prot for SFRP1 Gene

  • Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.

Gene Wiki entry for SFRP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFRP1 Gene

Genomics for SFRP1 Gene

Regulatory Elements for SFRP1 Gene

Promoters for SFRP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SFRP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SFRP1 Gene

Chromosome:
8
Start:
41,261,957 bp from pter
End:
41,309,497 bp from pter
Size:
47,541 bases
Orientation:
Minus strand

Genomic View for SFRP1 Gene

Genes around SFRP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFRP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFRP1 Gene

Proteins for SFRP1 Gene

  • Protein details for SFRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N474-SFRP1_HUMAN
    Recommended name:
    Secreted frizzled-related protein 1
    Protein Accession:
    Q8N474
    Secondary Accessions:
    • O00546
    • O14779

    Protein attributes for SFRP1 Gene

    Size:
    314 amino acids
    Molecular mass:
    35386 Da
    Quaternary structure:
    • Interacts with WNT1, WNT2 and FRZD6. Interacts with WNT4, WNT8 and MYOC (By similarity).
    Miscellaneous:
    • May have therapeutic use in cardiac surgery.

neXtProt entry for SFRP1 Gene

Proteomics data for SFRP1 Gene at MOPED

Post-translational modifications for SFRP1 Gene

  • Glycosylation at Asn 173
  • Modification sites at PhosphoSitePlus

Other Protein References for SFRP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SFRP1 (SFRP1)

No data available for DME Specific Peptides for SFRP1 Gene

Domains & Families for SFRP1 Gene

Gene Families for SFRP1 Gene

Protein Domains for SFRP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N474

UniProtKB/Swiss-Prot:

SFRP1_HUMAN :
  • The FZ domain is involved in binding with Wnt ligands.
  • Belongs to the secreted frizzled-related protein (sFRP) family.
Domain:
  • The FZ domain is involved in binding with Wnt ligands.
  • Contains 1 FZ (frizzled) domain.
  • Contains 1 NTR domain.
Family:
  • Belongs to the secreted frizzled-related protein (sFRP) family.
genes like me logo Genes that share domains with SFRP1: view

Function for SFRP1 Gene

Molecular function for SFRP1 Gene

GENATLAS Biochemistry:
Drosophila frizzled polarity homolog,secreted related protein 1,mouse sfrp 1 homolog,likely involved in WNT binding and signal transduction,deleted in breast carcinomas (see TSG8D)
UniProtKB/Swiss-Prot Function:
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.
UniProtKB/Swiss-Prot Induction:
Down-regulated in colorectal and breast tumors. Up-regulated in uterine leiomyomas under high estrogenic conditions. Expression, in leiomyomal cells, also increased both under hypoxic and serum deprivation conditions.

LifeMap Function Summary for SFRP1 Gene

SFRP1 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
genes like me logo Genes that share phenotypes with SFRP1: view

Animal Models for SFRP1 Gene

MGI Knock Outs for SFRP1:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SFRP1 Gene

Localization for SFRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFRP1 Gene

Secreted. Note=Cell membrane or extracellular matrix-associated. Released by heparin-binding.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SFRP1 Gene COMPARTMENTS Subcellular localization image for SFRP1 gene
Compartment Confidence
cytosol 5
extracellular 5
plasma membrane 5
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SFRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane ISS --
genes like me logo Genes that share ontologies with SFRP1: view

Pathways & Interactions for SFRP1 Gene

genes like me logo Genes that share pathways with SFRP1: view

SIGNOR curated interactions for SFRP1 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for SFRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001657 ureteric bud development IEA --
GO:0001756 somitogenesis IEA --
GO:0001843 neural tube closure IEA --
GO:0001954 positive regulation of cell-matrix adhesion ISS --
GO:0002244 hematopoietic progenitor cell differentiation IDA 19778523
genes like me logo Genes that share ontologies with SFRP1: view

Drugs & Compounds for SFRP1 Gene

(3) Drugs for SFRP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for SFRP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SFRP1: view

Transcripts for SFRP1 Gene

mRNA/cDNA for SFRP1 Gene

Unigene Clusters for SFRP1 Gene

Secreted frizzled-related protein 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SFRP1 Gene

No ASD Table

Relevant External Links for SFRP1 Gene

GeneLoc Exon Structure for
SFRP1
ECgene alternative splicing isoforms for
SFRP1

Expression for SFRP1 Gene

mRNA expression in normal human tissues for SFRP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SFRP1 Gene

This gene is overexpressed in Cervix - Ectocervix (x4.7) and Vagina (x4.2).

Protein differential expression in normal tissues from HIPED for SFRP1 Gene

This gene is overexpressed in Urine (24.3) and Testis (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SFRP1 Gene



SOURCE GeneReport for Unigene cluster for SFRP1 Gene Hs.213424

mRNA Expression by UniProt/SwissProt for SFRP1 Gene

Q8N474-SFRP1_HUMAN
Tissue specificity: Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes.
genes like me logo Genes that share expression patterns with SFRP1: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for SFRP1 Gene

Orthologs for SFRP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SFRP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SFRP1 35
  • 93.85 (n)
  • 98.23 (a)
SFRP1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SFRP1 35
  • 93.68 (n)
  • 97.58 (a)
SFRP1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sfrp1 35
  • 92.46 (n)
  • 94.9 (a)
Sfrp1 16
Sfrp1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SFRP1 35
  • 98.94 (n)
  • 99.36 (a)
SFRP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sfrp1 35
  • 91.59 (n)
  • 93.93 (a)
oppossum
(Monodelphis domestica)
Mammalia SFRP1 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves SFRP1 35
  • 84.82 (n)
  • 85.35 (a)
SFRP1 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sfrp1 35
  • 71.48 (n)
  • 71.48 (a)
Str.11327 35
African clawed frog
(Xenopus laevis)
Amphibia sfrp1-A-prov 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
sfrp1a 35
  • 68.84 (n)
  • 68.2 (a)
sfrp1a 36
  • 63 (a)
OneToMany
sfrp1b 36
  • 59 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y73B6BL.21 37
  • 36 (a)
sfrp-1 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8698 36
  • 36 (a)
OneToMany
Species with no ortholog for SFRP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SFRP1 Gene

ENSEMBL:
Gene Tree for SFRP1 (if available)
TreeFam:
Gene Tree for SFRP1 (if available)

Paralogs for SFRP1 Gene

Paralogs for SFRP1 Gene

(4) SIMAP similar genes for SFRP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SFRP1: view

Variants for SFRP1 Gene

Sequence variations from dbSNP and Humsavar for SFRP1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs12914 -- 41,262,633(-) TTACA(A/G)TAATC utr-variant-3-prime
rs13635 -- 41,264,740(-) CTAAT(A/G)ATTGG utr-variant-3-prime
rs730648 -- 41,293,133(-) AGCTG(C/T)GAGGG intron-variant
rs747417 -- 41,300,485(-) GATAC(A/C)CTTCT intron-variant
rs968427 -- 41,308,275(-) TTTAA(A/G)TAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SFRP1 Gene

Variant ID Type Subtype PubMed ID
nsv890843 CNV Gain 21882294
nsv831298 CNV Gain+Loss 17160897
esv33397 CNV Loss 17666407
esv1509288 CNV Insertion 17803354

Variation tolerance for SFRP1 Gene

Residual Variation Intolerance Score: 21.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.92; 91.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SFRP1 Gene

HapMap Linkage Disequilibrium report
SFRP1
Human Gene Mutation Database (HGMD)
SFRP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFRP1 Gene

Disorders for SFRP1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for SFRP1 Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
seckel syndrome 1
  • seckel syndrome
cutaneous telangiectasia and cancer syndrome, familial
  • familial cutaneous telangiectasia and cancer syndrome
glucocorticoid-induced osteoporosis
  • steroid-induced osteoporosis
osgood-schlatter's disease
  • osteochondrosis
meningothelial meningioma
  • meningotheliomatous meningioma
- elite association - COSMIC cancer census association via MalaCards
Search SFRP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SFRP1

Genetic Association Database (GAD)
SFRP1
Human Genome Epidemiology (HuGE) Navigator
SFRP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SFRP1
genes like me logo Genes that share disorders with SFRP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SFRP1 Gene

Publications for SFRP1 Gene

  1. Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. (PMID: 9192640) Finch P.W. … Rubin J.S. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23 67
  2. The SFRP family of WNT inhibitors function as novel tumor suppressor genes epigenetically silenced in medulloblastoma. (PMID: 20208569) Kongkham P.N. … Rutka J.T. (Oncogene 2010) 3 23
  3. Prostacyclin inhibits non-small cell lung cancer growth by a frizzled 9-dependent pathway that is blocked by secreted frizzled-related protein 1. (PMID: 20234818) Tennis M.A. … Winn R.A. (Neoplasia 2010) 3 23
  4. Transcriptional inactivation of secreted frizzled-related protein 1 by promoter hypermethylation as a potential biomarker for non-small cell lung cancer. (PMID: 20353273) Zhang Y.W. … Chen L.B. (Neoplasma 2010) 3 23
  5. Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. (PMID: 19072540) Moore W.J. … Bodine P.V. (J. Med. Chem. 2009) 3 23

Products for SFRP1 Gene

Sources for SFRP1 Gene

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