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Aliases for SFRP1 Gene

Aliases for SFRP1 Gene

  • Secreted Frizzled Related Protein 1 2 3 5
  • Secreted Apoptosis-Related Protein 2 3 4
  • SARP-2 3 4
  • SFRP-1 3 4
  • FRP-1 3 4
  • SARP2 3 4
  • FRP1 3 4
  • FRP 3 4
  • Secreted Frizzled-Related Protein 1 3
  • Frizzled-Related Protein 3
  • FrzA 3

External Ids for SFRP1 Gene

Previous GeneCards Identifiers for SFRP1 Gene

  • GC08M040568
  • GC08M041148
  • GC08M040860
  • GC08M041136
  • GC08M039647
  • GC08M041119

Summaries for SFRP1 Gene

Entrez Gene Summary for SFRP1 Gene

  • This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]

GeneCards Summary for SFRP1 Gene

SFRP1 (Secreted Frizzled Related Protein 1) is a Protein Coding gene. Diseases associated with SFRP1 include Glucocorticoid-Induced Osteoporosis and Meningothelial Meningioma. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling and Wnt Signaling Pathway and Pluripotency. GO annotations related to this gene include G-protein coupled receptor activity and heparin binding. An important paralog of this gene is SFRP5.

UniProtKB/Swiss-Prot for SFRP1 Gene

  • Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.

Gene Wiki entry for SFRP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFRP1 Gene

Genomics for SFRP1 Gene

Regulatory Elements for SFRP1 Gene

Enhancers for SFRP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F041284 0.6 ENCODE 16.9 +24.3 24298 1.6 SFRP1 ENSG00000253509 GC08P041299
GH08F041264 0.4 Ensembl 15.7 +45.0 44997 1.0 PKNOX1 HLF IKZF1 EBF1 SFRP1 GC08M041261 MIR548AO
GH08F041157 1.4 FANTOM5 Ensembl ENCODE 12.6 +150.9 150885 1.5 SFRP1 ENSG00000272479 GC08M041168 RNU6-356P
GH08F041286 0.2 ENCODE 11.7 +23.1 23101 0.2 SFRP1 ENSG00000253509 GC08P041299
GH08F041345 0.6 ENCODE 11.3 -36.6 -36612 0.6 CTCF MNT RAD21 SFRP1 GC08P041390
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SFRP1 on UCSC Golden Path with GeneCards custom track

Promoters for SFRP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001440735 1297 3601 CTCF ZNF362 SUZ12 SP2 NR3C1 ZFHX2 ZNF366 POLR2A ZNF512 ZBTB26

Genomic Location for SFRP1 Gene

Chromosome:
8
Start:
41,261,957 bp from pter
End:
41,309,497 bp from pter
Size:
47,541 bases
Orientation:
Minus strand

Genomic View for SFRP1 Gene

Genes around SFRP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFRP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFRP1 Gene

Proteins for SFRP1 Gene

  • Protein details for SFRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N474-SFRP1_HUMAN
    Recommended name:
    Secreted frizzled-related protein 1
    Protein Accession:
    Q8N474
    Secondary Accessions:
    • O00546
    • O14779

    Protein attributes for SFRP1 Gene

    Size:
    314 amino acids
    Molecular mass:
    35386 Da
    Quaternary structure:
    • Interacts with WNT1, WNT2 and FRZD6. Interacts with WNT4, WNT8 and MYOC (By similarity).
    Miscellaneous:
    • May have therapeutic use in cardiac surgery.

neXtProt entry for SFRP1 Gene

Post-translational modifications for SFRP1 Gene

  • Glycosylation at Asn 173
  • Modification sites at PhosphoSitePlus

Other Protein References for SFRP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SFRP1 (SFRP1)
  • Abcam antibodies for SFRP1
  • Cloud-Clone Corp. Antibodies for SFRP1

No data available for DME Specific Peptides for SFRP1 Gene

Domains & Families for SFRP1 Gene

Gene Families for SFRP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N474

UniProtKB/Swiss-Prot:

SFRP1_HUMAN :
  • The FZ domain is involved in binding with Wnt ligands.
  • Belongs to the secreted frizzled-related protein (sFRP) family.
Domain:
  • The FZ domain is involved in binding with Wnt ligands.
  • Contains 1 FZ (frizzled) domain.
  • Contains 1 NTR domain.
Family:
  • Belongs to the secreted frizzled-related protein (sFRP) family.
genes like me logo Genes that share domains with SFRP1: view

Function for SFRP1 Gene

Molecular function for SFRP1 Gene

GENATLAS Biochemistry:
Drosophila frizzled polarity homolog,secreted related protein 1,mouse sfrp 1 homolog,likely involved in WNT binding and signal transduction,deleted in breast carcinomas (see TSG8D)
UniProtKB/Swiss-Prot Function:
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.
UniProtKB/Swiss-Prot Induction:
Down-regulated in colorectal and breast tumors. Up-regulated in uterine leiomyomas under high estrogenic conditions. Expression, in leiomyomal cells, also increased both under hypoxic and serum deprivation conditions.

LifeMap Function Summary for SFRP1 Gene

SFRP1 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for SFRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IMP 14581477
GO:0004930 G-protein coupled receptor activity IBA --
GO:0005109 frizzled binding IPI 1927703
GO:0005515 protein binding IPI 10347172
GO:0008144 drug binding IDA 19072540
genes like me logo Genes that share ontologies with SFRP1: view
genes like me logo Genes that share phenotypes with SFRP1: view

Animal Models for SFRP1 Gene

MGI Knock Outs for SFRP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SFRP1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SFRP1 Gene

Localization for SFRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFRP1 Gene

Secreted. Note=Cell membrane or extracellular matrix-associated. Released by heparin-binding.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SFRP1 Gene COMPARTMENTS Subcellular localization image for SFRP1 gene
Compartment Confidence
cytosol 5
extracellular 5
plasma membrane 5
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SFRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005578 proteinaceous extracellular matrix IDA 9192640
GO:0005615 extracellular space IDA 9192640
GO:0005622 intracellular IDA 17500071
GO:0005829 cytosol IDA 14581477
genes like me logo Genes that share ontologies with SFRP1: view

Pathways & Interactions for SFRP1 Gene

genes like me logo Genes that share pathways with SFRP1: view

Pathways by source for SFRP1 Gene

SIGNOR curated interactions for SFRP1 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for SFRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IEP 16149051
GO:0001657 ureteric bud development IEA --
GO:0001756 somitogenesis IEA --
GO:0001843 neural tube closure IEA --
GO:0001954 positive regulation of cell-matrix adhesion ISS --
genes like me logo Genes that share ontologies with SFRP1: view

Drugs & Compounds for SFRP1 Gene

(4) Drugs for SFRP1 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
WAY 316606 Pharma sFRP-1 inhibitor 0

(3) Additional Compounds for SFRP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for SFRP1 Gene

Compound Action Cas Number
WAY 316606 sFRP-1 inhibitor 915759-45-4
genes like me logo Genes that share compounds with SFRP1: view

Drug Products

Transcripts for SFRP1 Gene

mRNA/cDNA for SFRP1 Gene

Unigene Clusters for SFRP1 Gene

Secreted frizzled-related protein 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SFRP1 Gene

No ASD Table

Relevant External Links for SFRP1 Gene

GeneLoc Exon Structure for
SFRP1
ECgene alternative splicing isoforms for
SFRP1

Expression for SFRP1 Gene

mRNA expression in normal human tissues for SFRP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SFRP1 Gene

This gene is overexpressed in Cervix - Ectocervix (x4.7) and Vagina (x4.2).

Protein differential expression in normal tissues from HIPED for SFRP1 Gene

This gene is overexpressed in Urine (24.3) and Testis (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SFRP1 Gene



NURSA nuclear receptor signaling pathways regulating expression of SFRP1 Gene:

SFRP1

SOURCE GeneReport for Unigene cluster for SFRP1 Gene:

Hs.213424

mRNA Expression by UniProt/SwissProt for SFRP1 Gene:

Q8N474-SFRP1_HUMAN
Tissue specificity: Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes.
genes like me logo Genes that share expression patterns with SFRP1: view

Primer Products

No data available for Protein tissue co-expression partners for SFRP1 Gene

Orthologs for SFRP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SFRP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SFRP1 34 35
  • 98.94 (n)
cow
(Bos Taurus)
Mammalia SFRP1 34 35
  • 93.85 (n)
dog
(Canis familiaris)
Mammalia SFRP1 34 35
  • 93.68 (n)
mouse
(Mus musculus)
Mammalia Sfrp1 34 16 35
  • 92.46 (n)
rat
(Rattus norvegicus)
Mammalia Sfrp1 34
  • 91.59 (n)
oppossum
(Monodelphis domestica)
Mammalia SFRP1 35
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves SFRP1 34 35
  • 84.82 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia sfrp1 34
  • 71.48 (n)
Str.11327 34
African clawed frog
(Xenopus laevis)
Amphibia sfrp1-A-prov 34
zebrafish
(Danio rerio)
Actinopterygii sfrp1a 34 35
  • 68.84 (n)
sfrp1b 35
  • 59 (a)
OneToMany
-- 34
worm
(Caenorhabditis elegans)
Secernentea Y73B6BL.21 36
  • 36 (a)
sfrp-1 35
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8698 35
  • 36 (a)
OneToMany
Species where no ortholog for SFRP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SFRP1 Gene

ENSEMBL:
Gene Tree for SFRP1 (if available)
TreeFam:
Gene Tree for SFRP1 (if available)

Paralogs for SFRP1 Gene

Paralogs for SFRP1 Gene

(4) SIMAP similar genes for SFRP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SFRP1: view

Variants for SFRP1 Gene

Sequence variations from dbSNP and Humsavar for SFRP1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10088390 -- 41,264,249(+) GAATC(C/G)TAAGC utr-variant-3-prime
rs10090158 -- 41,301,465(+) CCTAT(A/T)TATTG intron-variant
rs10092343 -- 41,265,958(+) GTCAG(C/G)AGTTC intron-variant
rs10092554 -- 41,293,764(+) Gtttt(G/T)ttttt intron-variant
rs10092633 -- 41,266,213(+) CCTCC(A/G)CCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SFRP1 Gene

Variant ID Type Subtype PubMed ID
esv1509288 CNV insertion 17803354
esv33397 CNV loss 17666407
esv3576565 CNV gain 25503493
esv3616987 CNV loss 21293372
nsv831298 CNV gain+loss 17160897

Variation tolerance for SFRP1 Gene

Residual Variation Intolerance Score: 21.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.92; 91.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SFRP1 Gene

Human Gene Mutation Database (HGMD)
SFRP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SFRP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFRP1 Gene

Disorders for SFRP1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for SFRP1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
glucocorticoid-induced osteoporosis
  • steroid-induced osteoporosis
meningothelial meningioma
  • meningotheliomatous meningioma
esophageal basaloid squamous cell carcinoma
  • basaloid squamous carcinoma of esophagus
osteoporosis
  • osteoporosis, postmenopausal, susceptibility
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
- elite association - COSMIC cancer census association via MalaCards
Search SFRP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SFRP1

Genetic Association Database (GAD)
SFRP1
Human Genome Epidemiology (HuGE) Navigator
SFRP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SFRP1
genes like me logo Genes that share disorders with SFRP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SFRP1 Gene

Publications for SFRP1 Gene

  1. Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. (PMID: 9192640) Finch P.W. … Rubin J.S. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 22 64
  2. Association of single nucleotide polymorphisms in secreted frizzled-related protein 1 gene with bone mineral density in Japanese women. (PMID: 19702942) Ohnaka K. … Takayanagi R. (Geriatr Gerontol Int 2009) 3 22 46 64
  3. Disulfide bond assignments of secreted Frizzled-related protein-1 provide insights about Frizzled homology and netrin modules. (PMID: 11741940) Chong J.M. … Speicher D.W. (J. Biol. Chem. 2002) 3 4 22 64
  4. Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling. (PMID: 10347172) Bafico A. … Aaronson S.A. (J. Biol. Chem. 1999) 3 4 22 64
  5. SARPs: a family of secreted apoptosis-related proteins. (PMID: 9391078) Melkonyan H.S. … Umansky S.R. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 64

Products for SFRP1 Gene

Sources for SFRP1 Gene

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