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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SFRP1 Gene

protein-coding   GIFtS: 61
GCID: GC08M041119

secreted frizzled-related protein 1
 Explore 61 diseases affiliated with
SFRP1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SFRP1    

Aliases
for SFRP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Secreted Frizzled-Related Protein 11 2     FRP12 3
FRP1 2 3 5     SARP-22 3
SARP21 2 3 5     SFRP-11
FRP-11 2 3     FrzA2
Secreted Apoptosis-Related Protein 22 3     

External Ids:    HGNC: 107761   Entrez Gene: 64222   Ensembl: ENSG000001043327   OMIM: 6041565   UniProtKB: Q8N4743   

Export aliases for SFRP1 gene to outside databases

Previous GC identifers: GC08M040568 GC08M041148 GC08M040860 GC08M041136 GC08M041238 GC08M039647


Summaries
for SFRP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SFRP1:
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative
Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic
silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene
may also be involved in determining the polarity of photoreceptor cells in the retina. (provided by RefSeq, Sep 2009)

UniProtKB/Swiss-Prot: SFRP1_HUMAN, Q8N474
Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction
with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases
intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in
vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the
S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By
similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription

Gene Wiki entry for SFRP1 (Secreted frizzled-related protein 1)


Genomic Views
for SFRP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SFRP1 gene promoter:
         C/EBPbeta   Pbx1a   AML1a   Pax-5   MyoD   FOXD1   LCR-F1   STAT1alpha   RORalpha2   CREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SFRP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SFRP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SFRP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.21   Ensembl cytogenetic band:  8p11.21   HGNC cytogenetic band: 8p11.21

SFRP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SFRP1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M041119:  view genomic region     (about GC identifiers)

Start:
 41,119,476 bp from pter      End:
 41,167,016 bp from pter
Size:
 47,541 bases      Orientation:
 minus strand

Proteins
for SFRP1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SFRP1_HUMAN, Q8N474 (See protein sequence)
Recommended Name: Secreted frizzled-related protein 1 precursor  
Size: 314 amino acids; 35386 Da
Subunit: Interacts with WNT1, WNT2 and FRZD6. Interacts with WNT4 and WNT8 (By similarity)
Subcellular location: Secreted. Note=Cell membrane or extracellular matrix-associated. Released by heparin-binding
Mass spectrometry: Mass=7266.4; Method=MALDI; Range=169-210; Note=Isoform N-glycosylated on Asn-173;
Source=PubMed:11741940;
Miscellaneous: May have therapeutic use in cardiac surgery
Secondary accessions: O00546 O14779

Explore the universe of human proteins at neXtProt for SFRP1: NX_Q8N474

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N474

    • SFRP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003003.3  
    ENSEMBL proteins: 
     ENSP00000220772   ENSP00000369174   ENSP00000442829  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: SFRP1
    OriGene Custom Protein Services for SFRP1 
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    Novus Biologicals SFRP1 Protein
    Novus Biologicals SFRP1 Lysate
    Sino Biological Recombinant Protein for SFRP1
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SFRP1

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005578proteinaceous extracellular matrix IDA9192640
    GO:0005615extracellular space IDA--
    GO:0005622intracellular IDA17500071
    GO:0005829cytosol IDA14581477


    SFRP1 for ontologies           About GeneDecksing



    SFRP1 Antibody Products: 
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    ThermoFisher Antibody for SFRP1

    Assay Products for SFRP1: 
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    Uscn ELISAs and CLIAs for SFRP1

    Protein Domains /
    Families
    for SFRP1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SFRP1 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR008993 TIMP-like_OB-fold
     IPR015526 Frizzled/SFRP
     IPR020067 Frizzled_dom
     IPR026559 SFRP1
     IPR001134 Netrin_domain

    Graphical View of Domain Structure for InterPro Entry Q8N474

    ProtoNet protein and cluster: Q8N474

    UniProtKB/Swiss-Prot: SFRP1_HUMAN, Q8N474
    Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)
    Similarity: Belongs to the secreted frizzled-related protein (sFRP) family
    Similarity: Contains 1 FZ (frizzled) domain
    Similarity: Contains 1 NTR domain


    Function
    for SFRP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SFRP1_HUMAN, Q8N474
    Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction
    with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases
    intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in
    vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the
    S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By
    similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription
    Induction: Down-regulated in colorectal and breast tumors. Up-regulated in uterine leiomyomas under high estrogenic
    conditions. Expression, in leiomyomal cells, also increased both under hypoxic and serum deprivation conditions

         Genatlas biochemistry entry for SFRP1:
    Drosophila frizzled polarity homolog,secreted related protein 1,mouse sfrp 1 homolog,likely involved in WNT binding and
    signal transduction,deleted in breast carcinomas (see TSG8D)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SFRP1
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate SFRP1 (see all 29):
    hsa-miR-3673 hsa-miR-513a-5p hsa-miR-4272 hsa-miR-128 hsa-miR-4263 hsa-miR-16-1* hsa-miR-144 hsa-miR-1323
    SwitchGear 3'UTR luciferase reporter plasmid: SFRP1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SFRP1 (see all 4)
    OriGene shRNA RFP: SFRP1
    OriGene siRNA: SFRP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SFRP1

    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
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    Cell Line
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    Search LifeMap BioReagents cell lines for SFRP1

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity IMP14581477
    GO:0005109frizzled binding IPI10347172
    GO:0008144drug binding IDA19072540
    GO:0008201heparin binding IDA9192640
    GO:0017147Wnt-protein binding IPI10347172


    SFRP1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Sfrp1tm1Aksh for SFRP1
         15/17 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Sfrp1) (see all 17):
     adipose tissue  cardiovascular system  craniofacial  embryogenesis  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  limbs/digits/tail 
     mortality/aging  nervous system  no phenotypic analysis  other  reproductive system 

    SFRP1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SFRP1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Wnt Signaling Pathway
    		Wnt signaling pathway0.30
    		Wnt Signaling Pathway NetPath0.22
    2Wnt / Hedgehog / Notch
    		Wnt / Hedgehog / Notch1.00
    3Validated targets of C-MYC transcriptional repression
    		Validated targets of C-MYC transcriptional repression1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SFRP1
        Wnt / Hedgehog / Notch

    2 BioSystems Pathways for SFRP1 
        Wnt Signaling Pathway NetPath
    Validated targets of C-MYC transcriptional repression


    1         Kegg Pathway  (Kegg details for SFRP1):
        Wnt signaling pathway


    SFRP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SFRP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/40 Interacting proteins for SFRP1 (Q8N4743 ENSP000002207724) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FZD6O603533, ENSP000003516054I2D: score=2 STRING: ENSP00000351605
    WNT1P046283, ENSP000002935494I2D: score=2 STRING: ENSP00000293549
    WNT2P095443, ENSP000002654414I2D: score=2 STRING: ENSP00000265441
    WNT4P567053, ENSP000002901674I2D: score=2 STRING: ENSP00000290167
    BARX1Q9HBU13, ENSP000002539684I2D: score=1 STRING: ENSP00000253968
    About this table

    Gene Ontology (GO): 5/93 biological process terms (GO ID links to tree view) (see all 93):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001649osteoblast differentiation IEP16149051
    GO:0001657ureteric bud development IEA--
    GO:0001756somitogenesis ----
    GO:0001843neural tube closure IEA--
    GO:0001944vasculature development IBA--


    SFRP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SFRP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SFRP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SFRP1
    6 Novoseek chemical compound relationships for SFRP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 70.3 7 16795071 (2), 16449975 (1), 18949430 (1), 18035687 (1) (see all 5)
    retinoic acid 17.2 3 19347729 (1), 15526363 (1)
    glycogen 9.19 2 17079847 (1)
    tyrosine 4.28 1 17500071 (1)
    testosterone 2.87 9 19277043 (3)
    heparin 0 24 17500071 (7), 10660608 (1)

    Search CenterWatch for drugs/clinical trials and news about SFRP1 

    Transcripts
    for SFRP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SFRP1 gene: 
    NM_003012.4  

    Unigene Cluster for SFRP1:

    Secreted frizzled-related protein 1
    Hs.213424  [show with all ESTs]
    Unigene Representative Sequence: NM_003012
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000220772(uc003xnt.3) ENST00000379845 ENST00000535263

    miRNA
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    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate SFRP1 (see all 29):
    hsa-miR-3673 hsa-miR-513a-5p hsa-miR-4272 hsa-miR-128 hsa-miR-4263 hsa-miR-16-1* hsa-miR-144 hsa-miR-1323
    SwitchGear 3'UTR luciferase reporter plasmid: SFRP1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF001900.1 AF017987.1 AF056087.1 AK127331.1 AK293090.1 AL049995.1 BC004466.1 BC036503.1 

    7 DOTS entries:

    DT.419510  DT.101982556  DT.86845459  DT.121481266  DT.100735166  DT.121481260  DT.100724189 

    24/311 AceView cDNA sequences (see all 311):

    CB215953 AI627824 BM970588 AA746162 AU121566 BQ002015 AA936010 AW090076 
    AW166215 BE856093 BM705126 Z44836 AW294583 AA322075 AI367271 CB126356 
    AA582397 AI679417 AW173278 T32665 CA389568 Z44950 AW957689 CB111824 

    GeneLoc Exon Structure


    Expression
    for SFRP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SFRP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATCAATATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SFRP1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HypoblastExtraembryonic Visceral EndodermAnterior Visceral Endoderm CellsExtraembryonic Tissues, Yolk Sac
    HypoblastExtraembryonic Visceral EndodermDistal Visceral Endoderm CellsExtraembryonic Tissues, Yolk Sac
    Intermediate MesodermIntermediate MesodermIntermediate Mesoderm
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/17 LifeMap Cells (see all 17) 
    NameCategory
    mK4 (Cell line)Kidney
    mK3 (Cell line)Kidney
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

    See SFRP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SFRP1

    SOURCE GeneReport for Unigene cluster: Hs.213424

    UniProtKB/Swiss-Prot: SFRP1_HUMAN, Q8N474
    Tissue specificity: Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart
    and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and
    vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including SFRP1 (see all 7): 
              Lung Cancer in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              Breast Cancer in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Prostate Cancer in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SFRP1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFRP1

    Orthologs
    for SFRP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SFRP1 gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SFRP11 secreted frizzled-related protein 1 84.82(n)
    85.35(a)    		   395237  NM_204553.1  NP_989884.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia sfrp1-A-prov2 secreted frizzled-related protein 1 76.03(n)    AF049908.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii AY050560.12   -- 79.91(n)   117510  AY050560.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y73B6BL.213   -- 36(a)   IV(6396933-6402093)   --


    ENSEMBL Gene Tree for SFRP1 (if available)
    TreeFam Gene Tree for SFRP1 (if available) 

    Paralogs
    for SFRP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SFRP1 gene
    FZD102  FZD32  FZD82  FZD12  FZD52  FZD22  FZD92  SFRP42  
    SMO2  FZD42  FZD62  FRZB2  FZD72  SFRP52  SFRP22  
    4 SIMAP similar genes for SFRP1 using alignment to 3 protein entries:     SFRP1_HUMAN (see all proteins):
    FRP1    SFRP5    SFRP2    FRZB

    SFRP1 for paralogs           About GeneDecksing



    Genomic Variants
    for SFRP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/890 NCBI SNPs in SFRP1 are shown (see all 890)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs132686981,2
    		C,F,H,--41118993(+) CTATAT/GCCCCA 1 -- ds50017Minor allele frequency- G:0.01NS EA NA 424
    rs1490289531,2
    		--41119071(+) ACAAGC/TTTTCC 1 -- ds50010--------
    rs1430341981,2
    		--41119098(+) TCTAAC/TATTGA 1 -- ds50010--------
    rs781447731,2
    		F,--41119213(+) CTGATC/TTGAAA 1 -- ds50012Minor allele frequency- T:0.06NA EA 240
    rs286410301,2
    		C,--41119260(+) TATAGG/CAGCAG 1 -- ds50012Minor allele frequency- C:0.32WA 120
    rs1921993271,2
    		--41119280(+) GGGAGA/GGTGGG 1 -- ds50010--------
    rs1384616851,2
    		--41119291(+) GGCCAC/TGGGTA 1 -- ds50010--------
    rs1824794201,2
    		--41119366(+) GAACTA/GGGACC 1 -- ds50010--------
    rs605870141,2
    		C,F,--41119454(+) GTGGGA/GAAAAA 1 -- ds50012Minor allele frequency- G:0.04WA EA 238
    rs47369581,2
    		C,F,A,H,--41119497(+) AGTGAT/CTTTAG 1 -- ut31 ese35Minor allele frequency- C:0.08NS NA EA 474

    HapMap Linkage Disequilibrium report for SFRP1 (41119476 - 41167016 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SFRP1
         1 CNV: 7687

    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing SFRP1:
    Gastric Cancer
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SFRP1
    DNA2.0 Custom Variant and Variant Library Synthesis for SFRP1

    Disorders / Diseases
    for SFRP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SFRP1 for disorders           About GeneDecksing

    OMIM gene information: 604156    OMIM disorders: --

    20/61 diseases for SFRP1 (see all 61):    About MalaCards
    clear cell renal cell carcinoma    familial chronic lymphocytic leukemia    renal cell carcinoma    chronic lymphocytic leukemia
    barrett's esophagus    oral squamous cell carcinoma    mantle cell lymphoma    adrenal hyperplasia
    lymphocytic leukemia    clear cell adenocarcinoma    squamous cell carcinoma    myeloid leukemia
    inflammatory bowel disease    transitional cell carcinoma    acute lymphoblastic leukemia    rheumatoid arthritis
    chronic myeloid leukemia    lymphoblastic leukemia    acute myeloid leukemia    mucoepidermoid carcinoma

    1 disease from the University of Copenhagen DISEASES database for SFRP1:
    Cancer

    10/22 Novoseek disease relationships for SFRP1 gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colorectal tumors 39.6 4 17131472 (2), 14871816 (1), 18396643 (1)
    cancer 37.2 12 17353908 (2), 17626620 (1), 14871816 (1), 18949430 (1) (see all 8)
    tumors 34.8 62 15289865 (6), 17699851 (5), 17465504 (4), 14871816 (3) (see all 20)
    carcinoma renal cell 31.8 9 17353908 (2), 18949430 (2), 17699841 (1), 19723665 (1)
    adenoma 28.5 7 17131472 (2), 17762966 (1), 18396643 (1)
    osteoporosis 28 4 19702942 (1), 19819694 (1)
    colorectal cancer 27.7 5 14871816 (2), 16077939 (1), 17762966 (1), 16328026 (1)
    allelic loss 26.7 2 16007200 (1)
    gastric cancer 21.1 19 17465504 (5), 16328026 (1), 17035233 (1), 17848950 (1)
    hepatocellular carcinoma 20.5 1 16795071 (1)

    Human Genome Epidemiology (HuGE) Navigator: SFRP1 (5 documents)

    Export disorders for SFRP1 gene to outside databases

    Publications
    for SFRP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SFRP1 gene, integrated from 9 sources (see all 177):
    (articles sorted by number of sources associating them with SFRP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. (PubMed id 9192640)1, 2, 3, 9 Finch P.W.... Rubin J.S. (1997)
    2. SARPs: a family of secreted apoptosis-related proteins. (PubMed id 9391078)1, 2, 3 Melkonyan H.S.... Umansky S.R. (1997)
    3. Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling. (PubMed id 10347172)1, 2, 9 Bafico A.... Aaronson S.A. (1999)
    4. Disulfide bond assignments of secreted Frizzled-related protein-1 provide insights about Frizzled homology and netrin modules. (PubMed id 11741940)1, 2, 9 Chong J.M.... Speicher D.W. (2002)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Secreted frizzled related protein 1 is overexpressed in uterine leiomyomas, associated with a high estrogenic environment and unrelated to proliferative activity. (PubMed id 11932307)1, 2 Fukuhara K.... Fujii S. (2002)
    7. Up-regulation of human secreted frizzled homolog in apoptosis and its down-regulation in breast tumors. (PubMed id 9724099)1, 2 Zhou Z.... Linder S. (1998)
    8. Hypermethylation and aberrant expression of Wnt antagonist secreted frizzled-related protein 1 in gastric cancer. (PubMed id 17465504)1, 9 Zhao C.H....Zhang N. (2007)
    9. Secreted frizzled-related protein 1 (SFRP1) protects fibroblasts from ceramide-induced apoptosis. (PubMed id 14581477)1, 9 Han X. and Amar S. (2004)
    10. Functional significance of secreted Frizzled-related protein 1 in metastatic renal cell carcinomas. (PubMed id 19723665)1, 9 Saini S....Dahiya R. (2009)

    External Searches for SFRP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SFRP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6422 HGNC: 10776 AceView: SFRP1 Ensembl:ENSG00000104332 euGenes: HUgn6422
    ECgene: SFRP1 Kegg: 6422 H-InvDB: SFRP1

    Other Databases showing SFRP1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SFRP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SFRP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SFRP1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SFRP1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SFRP1 gene:
    Search GeneIP for patents involving SFRP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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