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SFRP1 Gene

protein-coding   GIFtS: 63
GCID: GC08M041119

Secreted Frizzled-Related Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Secreted Frizzled-Related Protein 11 2     FRP12 3
FRP2 3 5     SARP-22 3
SARP22 3 5     sFRP-12 3
Secreted Apoptosis-Related Protein 22 3     FrzA2
FRP-12 3     

External Ids:    HGNC: 107761   Entrez Gene: 64222   Ensembl: ENSG000001043327   OMIM: 6041565   UniProtKB: Q8N4743   

Export aliases for SFRP1 gene to outside databases

Previous GC identifers: GC08M040568 GC08M041148 GC08M040860 GC08M041136 GC08M041238 GC08M039647


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SFRP1 Gene:
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative
Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling;
epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with
cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina.
(provided by RefSeq, Sep 2009)

GeneCards Summary for SFRP1 Gene:
SFRP1 (secreted frizzled-related protein 1) is a protein-coding gene. Diseases associated with SFRP1 include familial chronic lymphocytic leukemia, and ovarian clear cell adenocarcinoma. GO annotations related to this gene include PDZ domain binding and identical protein binding. An important paralog of this gene is FZD3.

UniProtKB/Swiss-Prot: SFRP1_HUMAN, Q8N474
Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct
interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types.
SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular
cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the
G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud
growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription

Gene Wiki entry for SFRP1 (Secreted frizzled-related protein 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_167187.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SFRP1 gene promoter:
         C/EBPbeta   Pbx1a   AML1a   Pax-5   MyoD   FOXD1   LCR-F1   STAT1alpha   RORalpha2   CREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSFRP1 promoter sequence
   Search Chromatin IP Primers for SFRP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SFRP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.21   Ensembl cytogenetic band:  8p11.21   HGNC cytogenetic band: 8p11.21

SFRP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SFRP1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M041119:  view genomic region     (about GC identifiers)

Start:
41,119,476 bp from pter      End:
41,167,016 bp from pter
Size:
47,541 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SFRP1_HUMAN, Q8N474 (See protein sequence)
Recommended Name: Secreted frizzled-related protein 1 precursor  
Size: 314 amino acids; 35386 Da
Subunit: Interacts with WNT1, WNT2 and FRZD6. Interacts with WNT4 and WNT8 (By similarity)
Mass spectrometry: Mass=7266.4; Method=MALDI; Range=169-210; Note=Isoform N-glycosylated on Asn-173;
Source=PubMed:11741940;
Miscellaneous: May have therapeutic use in cardiac surgery
Secondary accessions: O00546 O14779

Explore the universe of human proteins at neXtProt for SFRP1: NX_Q8N474

Explore proteomics data for SFRP1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn173

  • See SFRP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003003.3  
    ENSEMBL proteins: 
     ENSP00000220772   ENSP00000369174  
    Reactome Protein details: Q8N474

    SFRP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for SFRP1 (sFRP-1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SFRP1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SFRP1
    GenScript Custom Purified and Recombinant Proteins Services for SFRP1
    Novus Biologicals SFRP1 Protein
    Novus Biologicals SFRP1 Lysate
    Sino Biological Recombinant Protein for SFRP1
    Sino Biological Cell Lysate for SFRP1
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SFRP1

    SFRP1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SFRP1
    R&D Systems Antibodies for SFRP1 (sFRP-1)
    Cell Signaling Technology (CST) Antibodies for SFRP1 
    OriGene Antibodies for SFRP1
    OriGene Custom Antibody Services for SFRP1
    Novus Biologicals SFRP1 Antibodies
    Abcam antibodies for SFRP1
    Cloud-Clone Corp. Antibodies for SFRP1
    ThermoFisher Antibody for SFRP1
    LSBio Antibodies in human, mouse, rat for SFRP1

    SFRP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SFRP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SFRP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SFRP1
    Cloud-Clone Corp. CLIAs for SFRP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SFRP: Secreted frizzled-related proteins

    Selected InterPro protein domains (see all 6):
     IPR008993 TIMP-like_OB-fold
     IPR020067 Frizzled_dom
     IPR026559 SFRP1/5
     IPR015526 Frizzled/SFRP
     IPR001134 Netrin_domain

    Graphical View of Domain Structure for InterPro Entry Q8N474

    ProtoNet protein and cluster: Q8N474

    UniProtKB/Swiss-Prot: SFRP1_HUMAN, Q8N474
    Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)
    Similarity: Belongs to the secreted frizzled-related protein (sFRP) family
    Similarity: Contains 1 FZ (frizzled) domain
    Similarity: Contains 1 NTR domain


    SFRP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SFRP1_HUMAN, Q8N474
    Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct
    interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types.
    SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular
    cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the
    G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud
    growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription
    Induction: Down-regulated in colorectal and breast tumors. Up-regulated in uterine leiomyomas under high
    estrogenic conditions. Expression, in leiomyomal cells, also increased both under hypoxic and serum deprivation
    conditions

         Genatlas biochemistry entry for SFRP1:
    Drosophila frizzled polarity homolog,secreted related protein 1,mouse sfrp 1 homolog,likely involved in WNT
    binding and signal transduction,deleted in breast carcinomas (see TSG8D)

         Summary: 
    SFRP1 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
                
    Brain: Dopaminergic neuron-like cells , Dopaminergic neuron-like cells
    Neurons: Dopaminergic neuron-like cells , Dopaminergic neuron-like cells

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity IMP14581477
    GO:0005109frizzled binding IPI10347172
    GO:0005515protein binding IPI10347172
    GO:0008144drug binding IDA19072540
    GO:0008201heparin binding IDA10660608
         
    SFRP1 for ontologies           About GeneDecksing


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 4 alleles(MGI details for Sfrp1) (see all 17):
     adipose tissue  cardiovascular system  craniofacial  embryogenesis  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  limbs/digits/tail 
     mortality/aging  nervous system  no phenotypic analysis  other  reproductive system 

    SFRP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sfrp1tm1Aksh for SFRP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SFRP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SFRP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SFRP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SFRP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SFRP1:
    hsa-mir-335-5p (MIRT017159)

    Block miRNA regulation of human, mouse, rat SFRP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SFRP1 (see all 29):
    hsa-miR-3673 hsa-miR-513a-5p hsa-miR-4272 hsa-miR-128 hsa-miR-4263 hsa-miR-16-1* hsa-miR-144 hsa-miR-1323
    SwitchGear 3'UTR luciferase reporter plasmidSFRP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SFRP1
    Predesigned siRNA for gene silencing in human, mouse, rat SFRP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SFRP1

    Clone
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    OriGene clones in human, mouse for SFRP1 (see all 7)
    OriGene ORF clones in mouse, rat for SFRP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SFRP1 (NM_003012)
    Sino Biological Human cDNA Clone for SFRP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SFRP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFRP1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SFRP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SFRP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFRP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SFRP1_HUMAN, Q8N474: Secreted. Note=Cell membrane or extracellular matrix-associated. Released by heparin-binding
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    extracellular5
    plasma membrane4
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005578proteinaceous extracellular matrix IDA9192640
    GO:0005615extracellular space IDA10980594
    GO:0005622intracellular IDA17500071
    GO:0005829cytosol IDA14581477

    SFRP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SFRP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    2Non-Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    Canonical Wnt Pathway0.53
    3Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    4Validated targets of C-MYC transcriptional repression
    Validated targets of C-MYC transcriptional repression

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SFRP1
        Wnt / Hedgehog / Notch

    2 BioSystems Pathways for SFRP1
        Wnt Signaling Pathway NetPath
    Validated targets of C-MYC transcriptional repression

    2 Sino Biological Pathways for SFRP1
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    1 Reactome Pathway for SFRP1
        negative regulation of TCF-dependent signaling by WNT ligand antagonists


    1 Kegg Pathway  (Kegg details for SFRP1):
        Wnt signaling pathway


    SFRP1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SFRP1 (see all 7): 
              Lung Cancer in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              Breast Cancer in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Prostate Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SFRP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SFRP1 (Q8N4741, 3 ENSP000002207724) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FZD6O603531, 3, ENSP000003516054EBI-3940687,EBI-8754490 I2D: score=2 STRING: ENSP00000351605
    WNT1P046283, ENSP000002935494I2D: score=2 STRING: ENSP00000293549
    WNT2P095443, ENSP000002654414I2D: score=2 STRING: ENSP00000265441
    WNT4P567053, ENSP000002901674I2D: score=2 STRING: ENSP00000290167
    BARX1Q9HBU13, ENSP000002539684I2D: score=1 STRING: ENSP00000253968
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 95):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001649osteoblast differentiation IEP16149051
    GO:0001657ureteric bud development IEA--
    GO:0001756somitogenesis ----
    GO:0001843neural tube closure IEA--
    GO:0001944vasculature development IBA--

    SFRP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SFRP1

    6 Novoseek inferred chemical compound relationships for SFRP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 70.3 7 16795071 (2), 16449975 (1), 18949430 (1), 18035687 (1) (see all 5)
    retinoic acid 17.2 3 19347729 (1), 15526363 (1)
    glycogen 9.19 2 17079847 (1)
    tyrosine 4.28 1 17500071 (1)
    testosterone 2.87 9 19277043 (3)
    heparin 0 24 17500071 (7), 10660608 (1)



    SFRP1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SFRP1 gene: 
    NM_003012.4  

    Unigene Cluster for SFRP1:

    Secreted frizzled-related protein 1
    Hs.213424  [show with all ESTs]
    Unigene Representative Sequence: NM_003012
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000220772(uc003xnt.3) ENST00000379845
    miRNA
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    Block miRNA regulation of human, mouse, rat SFRP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SFRP1 (see all 29):
    hsa-miR-3673 hsa-miR-513a-5p hsa-miR-4272 hsa-miR-128 hsa-miR-4263 hsa-miR-16-1* hsa-miR-144 hsa-miR-1323
    SwitchGear 3'UTR luciferase reporter plasmidSFRP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SFRP1
    Clone
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    GenScript: all cDNA clones in your preferred vector: SFRP1 (NM_003012)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFRP1
    Primer
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    OriGene qPCR primer pairs and template standards for SFRP1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SFRP1
      QuantiTect SYBR Green Assays in human, mouse, rat SFRP1
      QuantiFast Probe-based Assays in human, mouse, rat SFRP1

    Additional mRNA sequence: 

    AF001900.1 AF017987.1 AF056087.1 AK127331.1 AK293090.1 AL049995.1 BC004466.1 BC036503.1 

    7 DOTS entries:

    DT.419510  DT.101982556  DT.86845459  DT.121481266  DT.100735166  DT.121481260  DT.100724189 

    Selected AceView cDNA sequences (see all 311):

    BM970588 AI148397 AW957689 CA389568 CB148514 CB149331 Z44836 AI373956 
    AI913160 CB111824 CD558546 AI298333 AA777054 AA424593 CB215953 CB126356 
    BG253035 AA346607 AW173278 CR613872 BE856093 AA322075 CA389569 AI679927 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SFRP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCAATATT
    SFRP1 Expression
    About this image


    SFRP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 31) fully expand
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
             Metanephros
             mK4
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Midbrain tegmentum
             Ventral/hypothalamic-like neurons
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 4 entries
             PureStem 4D20.8, NCr-fac Progenitor
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Mature Endothelial Cells Corneal Endothelium
             Lens
    SFRP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SFRP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.213424

    UniProtKB/Swiss-Prot: SFRP1_HUMAN, Q8N474
    Tissue specificity: Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in
    heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells
    and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SFRP1 (see all 7): 
              Lung Cancer in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              Breast Cancer in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Prostate Cancer in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SFRP1
    OriGene qSTAR qPCR primer pairs in human, mouse for SFRP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SFRP1
    QuantiTect SYBR Green Assays in human, mouse, rat SFRP1
    QuantiFast Probe-based Assays in human, mouse, rat SFRP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFRP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for SFRP1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sfrp11 , 5 secreted frizzled-related protein 11, 5 92.46(n)1
    94.9(a)1
      8 (11.48 cM)5
    203771  NM_013834.31  NP_038862.21 
     234115025 
    chicken
    (Gallus gallus)
    Aves SFRP11 secreted frizzled-related protein 1 84.82(n)
    85.35(a)
      395237  NM_204553.1  NP_989884.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia sfrp1-A-prov2 secreted frizzled-related protein 1 76.03(n)    AF049908.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AY050560.12   -- 79.91(n)   117510  AY050560.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y73B6BL.213   -- 36(a)   IV(6396933-6402093)   --


    ENSEMBL Gene Tree for SFRP1 (if available)
    TreeFam Gene Tree for SFRP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SFRP1 gene
    FZD32  FZD102  FZD82  FZD12  FZD52  FZD22  FZD92  SFRP42  
    SMO2  FZD42  FZD62  FRZB2  SFRP52  FZD72  SFRP22  
    4 SIMAP similar genes for SFRP1 using alignment to 3 protein entries:     SFRP1_HUMAN (see all proteins):
    FRP1    SFRP5    SFRP2    FRZB

    SFRP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SFRP1 (see all 1009)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs132686981,2
    C,F,H--41118993(+) CTATAT/GCCCCA 1 -- ds50017Minor allele frequency- G:0.01NS EA NA 424
    rs1490289531,2
    --41119071(+) ACAAGC/TTTTCC 1 -- ds50010--------
    rs1430341981,2
    --41119098(+) TCTAAC/TATTGA 1 -- ds50010--------
    rs781447731,2
    C,F--41119213(+) CTGATC/TTGAAA 1 -- ds50012Minor allele frequency- T:0.06NA EA 240
    rs286410301,2
    C,F--41119260(+) TATAGG/CAGCAG 1 -- ds50012Minor allele frequency- C:0.32WA 120
    rs1921993271,2
    --41119280(+) GGGAGA/GGTGGG 1 -- ds50010--------
    rs1384616851,2
    --41119291(+) GGCCAC/TGGGTA 1 -- ds50010--------
    rs1824794201,2
    --41119366(+) GAACTA/GGGACC 1 -- ds50010--------
    rs1129334651,2
    C--41119402(+) GAGGAC/GAAAGA 1 -- ds50011Minor allele frequency- G:0.00CSA 1
    rs605870141,2
    C,F--41119454(+) GTGGGA/GAAAAA 1 -- ds50012Minor allele frequency- G:0.04WA EA 238

    HapMap Linkage Disequilibrium report for SFRP1 (41119476 - 41167016 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SFRP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1509288CNV Insertion17803354
    esv33397CNV Loss17666407
    nsv890843CNV Gain21882294
    nsv831298CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing SFRP1:
    Gastric Cancer
    SeqTarget long-range PCR primers for resequencing SFRP1
    DNA2.0 Custom Variant and Variant Library Synthesis for SFRP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604156    OMIM disorders: --

    Selected diseases for SFRP1 (see all 56):    
    About MalaCards
    familial chronic lymphocytic leukemia    ovarian clear cell adenocarcinoma    mucoepidermoid carcinoma    clear cell adenocarcinoma
    clear cell renal cell carcinoma    keratoconus    renal cell carcinoma    osteoporosis
    mantle cell lymphoma    barrett's esophagus    myeloma    osteoarthritis
    hepatocellular carcinoma    chronic lymphocytic leukemia    chronic myeloid leukemia    leiomyoma
    transitional cell carcinoma    oral cancer    myeloid leukemia    medulloblastoma

    1 disease from the University of Copenhagen DISEASES database for SFRP1:
    Cancer

    SFRP1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for SFRP1 gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colorectal tumors 39.6 4 17131472 (2), 14871816 (1), 18396643 (1)
    cancer 37.2 12 17353908 (2), 17626620 (1), 14871816 (1), 18949430 (1) (see all 8)
    tumors 34.8 62 15289865 (6), 17699851 (5), 17465504 (4), 14871816 (3) (see all 20)
    carcinoma renal cell 31.8 9 17353908 (2), 18949430 (2), 17699841 (1), 19723665 (1)
    adenoma 28.5 7 17131472 (2), 17762966 (1), 18396643 (1)
    osteoporosis 28 4 19702942 (1), 19819694 (1)
    colorectal cancer 27.7 5 14871816 (2), 16077939 (1), 17762966 (1), 16328026 (1)
    allelic loss 26.7 2 16007200 (1)
    gastric cancer 21.1 19 17465504 (5), 16328026 (1), 17035233 (1), 17848950 (1)
    hepatocellular carcinoma 20.5 1 16795071 (1)

    Genetic Association Database (GAD): SFRP1
    Human Genome Epidemiology (HuGE) Navigator: SFRP1 (5 documents)

    Export disorders for SFRP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SFRP1 gene, integrated from 10 sources (see all 189):
    (articles sorted by number of sources associating them with SFRP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. (PubMed id 9192640)1, 2, 3, 9 Finch P.W.... Rubin J.S. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    2. SARPs: a family of secreted apoptosis-related proteins. (PubMed id 9391078)1, 2, 3 Melkonyan H.S.... Umansky S.R. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    3. Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling. (PubMed id 10347172)1, 2, 9 Bafico A.... Aaronson S.A. (J. Biol. Chem. 1999)
    4. Disulfide bond assignments of secreted Frizzled-related protein-1 provide insights about Frizzled homology and netrin modules. (PubMed id 11741940)1, 2, 9 Chong J.M.... Speicher D.W. (J. Biol. Chem. 2002)
    5. Association of single nucleotide polymorphisms in secreted frizzled-related protein 1 gene with bone mineral density in Japanese women. (PubMed id 19702942)1, 4, 9 Ohnaka K....Takayanagi R. (amp 2009)
    6. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    7. Genetic variation in immune signaling genes differentially expressed in asthmatic lung tissues. (PubMed id 18774388)1, 4 Tremblay K....Laprise C. (J. Allergy Clin. Immunol. 2008)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Secreted frizzled related protein 1 is overexpressed in uterine leiomyomas, associated with a high estrogenic environment and unrelated to proliferative activity. (PubMed id 11932307)1, 2 Fukuhara K.... Fujii S. (J. Clin. Endocrinol. Metab. 2002)
    10. Up-regulation of human secreted frizzled homolog in apoptosis and its down-regulation in breast tumors. (PubMed id 9724099)1, 2 Zhou Z.... Linder S. (Int. J. Cancer 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6422 HGNC: 10776 AceView: SFRP1 Ensembl:ENSG00000104332 euGenes: HUgn6422
    ECgene: SFRP1 Kegg: 6422 H-InvDB: SFRP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SFRP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SFRP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SFRP1 gene:
    Search GeneIP for patents involving SFRP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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