SFR1 Gene
protein-coding GIFtS: 41
GCID: GC10P105882
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SWI5-dependent recombination repair 1(Previous names: chromosome 10 open reading frame 78, MEI5 recombination...)
(Previous symbols: C10orf78, MEIR5)
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Aliases
for SFR1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SWI5-Dependent Recombination Repair 11 2 | | FLJ419601 | | C10orf781 2 3 | | Chromosome 10 Open Reading Frame 781 | | MEI51 2 3 | | MEI5 Recombination Repair Protein Homolog (S. Cerevisiae)1 | | MEIR51 2 3 | | MEI5 Recombination Repair Protein Homolog2 | | BA373N18.11 | | Swi5-Dependent Recombination DNA Repair Protein 1 Homolog2 | | Meiosis Protein 5 Homolog2 3 | | SWI5-Dependent Recombination Repair Protein 12 |
Export aliases for SFR1 gene to outside databases |
Summaries
for SFR1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SFR1_HUMAN, Q86XK3Function: Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologousrecombination
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Genomic Views
for SFR1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SFR1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SFR1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SFR1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q25.1 Ensembl cytogenetic band: 10q25.1 HGNC cytogenetic band: 10q25.1SFR1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P105882: view genomic region
(about GC identifiers)
Start:
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105,881,816 bp from pter |
End:
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105,886,143 bp from pter |
Size:
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4,328 bases |
Orientation:
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plus strand |
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Proteins
for SFR1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SFR1_HUMAN, Q86XK3 (See
protein sequence)Recommended Name: Swi5-dependent recombination DNA repair protein 1 homolog Size: 245 amino acids; 28262 Da
Subunit: Component of the SWI5-SFR1 complex. Interacts with RAD51; the interaction is weak
Subcellular location: Nucleus (By similarity)
Secondary accessions: A8K569 B2RTV8 Q5JT39 Q5JT40 Q8WW47Alternative splicing: 3 isoforms: Q86XK3-1 Q86XK3-2 Q86XK3-3 (Gene prediction based on EST data)Explore the universe of human proteins at neXtProt for SFR1: NX_Q86XK3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86XK3
SFR1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001002759.1 NP_660290.3
ENSEMBL proteins: ENSP00000358744 ENSP00000358742 ENSP00000338089
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SFR1 for ontologies About GeneDecksing
SFR1 Antibody Products:
Assay Products for SFR1: |
Protein
Domains /
Families
for SFR1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SFR1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q86XK3ProtoNet protein and cluster: Q86XK3 UniProtKB/Swiss-Prot: SFR1_HUMAN, Q86XK3Similarity: Belongs to the SFR1/MEI5 family |
Function
for SFR1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SFR1_HUMAN, Q86XK3Function: Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologousrecombination
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFR1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFR1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for SFR1 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SFR1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFR1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFR1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
SFR1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SFR1:
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Pathways & Interactions
for SFR1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SFR1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/6 Interacting proteins for SFR1 (Q86XK33 ENSP000003587424) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000724 | double-strand break repair via homologous recombination |
IMP | -- |
SFR1 for ontologies About GeneDecksing
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Drugs & Compounds
for SFR1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SFR1
Search CenterWatch for drugs/clinical trials and news about SFR1
|
Transcripts
for SFR1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SFR1 gene (2 alternative transcripts): NM_001002759.1 NM_145247.4 Unigene Cluster for SFR1: SWI5-dependent recombination repair 1 Hs.93667 [show with all ESTs]Unigene Representative Sequence: AK1239544 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369729(uc001kxs.3 uc001kxt.3) ENST00000463224 ENST00000369727(uc001kxu.3)
ENST00000336358(uc001kxv.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFR1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFR1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for SFR1 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SFR1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFR1 |
Additional cDNA sequence: AK123954.1 AK291184.1 BC020892.2 BC047587.2 BC140835.1 4 DOTS entries: DT.95141653 DT.101982280 DT.95234896 DT.40118485 24/52 AceView cDNA sequences (see all 52): NM_145247 AI659652 BU620322 BM763377 NM_001002759 CA412135 BQ774652 BM756680 BC047587 BC043256 BM712505 BQ182393 BM766496 CB111855 AK123954 BX952488 BM766505 BI830171 BM673783 BG942691 AW337344 BI560891 BX499179 H83545
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SFR1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b |
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| SP1: | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SFR1
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Expression
for SFR1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SFR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAAACTTAG
About this image
See SFR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SFR1
SOURCE GeneReport for Unigene cluster: Hs.93667
UniProtKB/Swiss-Prot: SFR1_HUMAN, Q86XK3Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for SFR1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SFR1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat SFR1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SFR1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SFR1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFR1 |
Orthologs
for SFR1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SFR1 gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for SFR1 (if available)
TreeFam Gene Tree for SFR1 (if available) |
Paralogs
for SFR1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SFR1 gene
SFR1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for SFR1
PGOHUM00000241420 PGOHUM00000241518
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Genomic Variants
for SFR1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SFR1 (105881816 - 105886143 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SFR1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SFR1 |
|
Disorders
/ Diseases
for SFR1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SFR1 for disorders About GeneDecksing
2  diseases for SFR1: About MalaCardsalzheimer's disease schizophrenia
Export disorders for SFR1 gene to outside databases
|
Publications
for SFR1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SFR1 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with SFR1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The role of human SWI5-MEI5 complex in homologous recombination repair. (PubMed id 21252223)1, 2, 3 Yuan J. and Chen J. (2011)
- The epistatic relationship between BRCA2 and the othe r RAD51 mediators in homologous recombination. (PubMed id 21779174)1, 3 Qing Y....Takeda S. (2011)
- Role for the mammalian Swi5-Sfr1 complex in DNA stran d break repair through homologous recombination. (PubMed id 20976249)1, 3 Akamatsu Y. and Jasin M. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. (PubMed id 17043677)1 Camargo L.M....Brandon N.J. (2007)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
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External Searches for SFR1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SFR1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SFR1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SFR1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SFR1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SFR1 gene:
Search GeneIP for patents involving SFR1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SFR1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SFR1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SFR1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SFR1 | | | OriGene Protein Over-expression Lysate for SFR1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SFR1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFR1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFR1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SFR1 | | OriGene Custom Protein Services for SFR1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SFR1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SFR1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SFR1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SFR1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SFR1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SFR1 |
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 |  |  |  | |
| | | | Search Tocris compounds for SFR1 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFR1 |
|  |  |  | | | | ThermoFisher Antibodies for SFR1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFR1 |
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