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Aliases for SFR1 Gene

Aliases for SFR1 Gene

  • SWI5 Dependent Homologous Recombination Repair Protein 1 2 3 5
  • SWI5-Dependent Recombination Repair 1 2 3
  • Meiosis Protein 5 Homolog 3 4
  • C10orf78 3 4
  • MEIR5 3 4
  • MEI5 3 4
  • MEI5 Recombination Repair Protein Homolog (S. Cerevisiae) 2
  • Swi5-Dependent Recombination DNA Repair Protein 1 Homolog 3
  • SWI5-Dependent Homologous Recombination Repair Protein 1 2
  • SWI5-Dependent Recombination Repair Protein 1 3
  • MEI5 Recombination Repair Protein Homolog 3
  • Chromosome 10 Open Reading Frame 78 2
  • BA373N18.1 3

External Ids for SFR1 Gene

Previous HGNC Symbols for SFR1 Gene

  • C10orf78
  • MEIR5

Previous GeneCards Identifiers for SFR1 Gene

  • GC10P105882

Summaries for SFR1 Gene

GeneCards Summary for SFR1 Gene

SFR1 (SWI5 Dependent Homologous Recombination Repair Protein 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SFR1 Gene

  • Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination (PubMed:21252223). Acts as a transcriptional modulator for ESR1 (PubMed:23874500).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFR1 Gene

Genomics for SFR1 Gene

Regulatory Elements for SFR1 Gene

Enhancers for SFR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F104109 1.4 FANTOM5 Ensembl ENCODE 42.7 -11.9 -11904 1.6 HDAC1 PKNOX1 JUN SIN3A EBF1 PRDM10 FOS MTA2 CEBPB EP300 SFR1 MIR936 COL17A1 STN1 CFAP43 GSTO1 CFAP58 SLK
GH10F104316 1.8 FANTOM5 Ensembl ENCODE 15.4 +206.7 206714 24.8 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 PDCD11 ITPRIP GSTO2 ENSG00000260461 CFAP58 SFR1 CFAP58-AS1 STN1 GSTO1 SLK
GH10F104089 0.3 FANTOM5 60 -32.2 -32236 0.3 SFR1 GSTO1 CFAP58 SLK COL17A1 MIR936
GH10F104258 1.2 FANTOM5 ENCODE 7.7 +138.4 138354 3.0 CBX3 TAL1 JUN YY1 POLR2A NCOR1 FOS TRIM24 SMARCE1 ZNF362 GSTO2 GSTO1 MIR609 SFR1 SLK CFAP58 ITPRIP GC10M104249 MIR4482
GH10F104092 0.8 ENCODE 11 -28.5 -28548 2.5 JUN ZEB1 RFX5 ZNF7 HIC1 ZNF366 ZNF143 FOS ZNF639 ZNF280D SFR1 CFAP43 COL17A1 MIR936
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SFR1 on UCSC Golden Path with GeneCards custom track

Promoters for SFR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000361226 42 2601 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 ZNF207

Genomic Location for SFR1 Gene

Chromosome:
10
Start:
104,122,058 bp from pter
End:
104,126,385 bp from pter
Size:
4,328 bases
Orientation:
Plus strand

Genomic View for SFR1 Gene

Genes around SFR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFR1 Gene

Proteins for SFR1 Gene

  • Protein details for SFR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XK3-SFR1_HUMAN
    Recommended name:
    Swi5-dependent recombination DNA repair protein 1 homolog
    Protein Accession:
    Q86XK3
    Secondary Accessions:
    • A8K569
    • B2RTV8
    • Q5JT39
    • Q5JT40
    • Q8WW47

    Protein attributes for SFR1 Gene

    Size:
    245 amino acids
    Molecular mass:
    28262 Da
    Quaternary structure:
    • Component of the SWI5-SFR1 complex. Interacts with RAD51; the interaction is weak (PubMed:21252223). Interacts with ESR1 in the ligand-independent and ligand-dependent manner (PubMed:23874500).

    Alternative splice isoforms for SFR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SFR1 Gene

Post-translational modifications for SFR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SFR1 Gene

No data available for DME Specific Peptides for SFR1 Gene

Domains & Families for SFR1 Gene

Protein Domains for SFR1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SFR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86XK3

UniProtKB/Swiss-Prot:

SFR1_HUMAN :
  • Belongs to the SFR1/MEI5 family.
Family:
  • Belongs to the SFR1/MEI5 family.
genes like me logo Genes that share domains with SFR1: view

No data available for Gene Families for SFR1 Gene

Function for SFR1 Gene

Molecular function for SFR1 Gene

UniProtKB/Swiss-Prot Function:
Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination (PubMed:21252223). Acts as a transcriptional modulator for ESR1 (PubMed:23874500).

Gene Ontology (GO) - Molecular Function for SFR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21252223
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IDA 23874500
genes like me logo Genes that share ontologies with SFR1: view
genes like me logo Genes that share phenotypes with SFR1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SFR1 Gene

Localization for SFR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFR1 Gene

Nucleus. Note=Colocalizes with ESR1 in the nucleus. {ECO:0000269 PubMed:23874500}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SFR1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 1

Gene Ontology (GO) - Cellular Components for SFR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0032798 Swi5-Sfr1 complex IDA 21252223
genes like me logo Genes that share ontologies with SFR1: view

Pathways & Interactions for SFR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SFR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IMP 21252223
GO:0006281 DNA repair IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
genes like me logo Genes that share ontologies with SFR1: view

No data available for Pathways by source and SIGNOR curated interactions for SFR1 Gene

Transcripts for SFR1 Gene

Unigene Clusters for SFR1 Gene

SWI5-dependent recombination repair 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SFR1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1:
SP2: - -
SP3: - -
SP4:

Relevant External Links for SFR1 Gene

GeneLoc Exon Structure for
SFR1
ECgene alternative splicing isoforms for
SFR1

Expression for SFR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SFR1 Gene

Protein differential expression in normal tissues from HIPED for SFR1 Gene

This gene is overexpressed in Colon muscle (64.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SFR1 Gene



Protein tissue co-expression partners for SFR1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SFR1 Gene:

SFR1

SOURCE GeneReport for Unigene cluster for SFR1 Gene:

Hs.93667

mRNA Expression by UniProt/SwissProt for SFR1 Gene:

Q86XK3-SFR1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with SFR1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SFR1 Gene

Orthologs for SFR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SFR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SFR1 34 35
  • 99.46 (n)
cow
(Bos Taurus)
Mammalia SFR1 34 35
  • 87.24 (n)
dog
(Canis familiaris)
Mammalia SFR1 34 35
  • 86.19 (n)
rat
(Rattus norvegicus)
Mammalia Sfr1 34
  • 75.31 (n)
mouse
(Mus musculus)
Mammalia Sfr1 34 16 35
  • 68.35 (n)
oppossum
(Monodelphis domestica)
Mammalia SFR1 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SFR1 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves SFR1 34 35
  • 61.49 (n)
lizard
(Anolis carolinensis)
Reptilia SFR1 35
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sfr1 34
  • 57.24 (n)
zebrafish
(Danio rerio)
Actinopterygii sfr1 34 35
  • 53.44 (n)
Species where no ortholog for SFR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SFR1 Gene

ENSEMBL:
Gene Tree for SFR1 (if available)
TreeFam:
Gene Tree for SFR1 (if available)

Paralogs for SFR1 Gene

Pseudogenes.org Pseudogenes for SFR1 Gene

genes like me logo Genes that share paralogs with SFR1: view

No data available for Paralogs for SFR1 Gene

Variants for SFR1 Gene

Sequence variations from dbSNP and Humsavar for SFR1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1052001 -- 104,126,056(+) ATCCC(A/G)ATGAA utr-variant-3-prime
rs10786783 -- 104,123,007(+) GTCAG(A/G)CTCAG reference, missense
rs10883969 -- 104,124,358(+) CTTTT(C/T)TCTCT intron-variant
rs111656309 -- 104,121,105(+) GCGGG(-/GC)CGCGG upstream-variant-2KB
rs11191927 -- 104,122,495(+) TCTCC(A/G)CTGTG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SFR1 Gene

Variant ID Type Subtype PubMed ID
nsv831971 CNV gain 17160897

Variation tolerance for SFR1 Gene

Residual Variation Intolerance Score: 80.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.58; 78.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SFR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SFR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFR1 Gene

Disorders for SFR1 Gene

Relevant External Links for SFR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SFR1

No disorders were found for SFR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SFR1 Gene

Publications for SFR1 Gene

  1. The role of human SWI5-MEI5 complex in homologous recombination repair. (PMID: 21252223) Yuan J. … Chen J. (J. Biol. Chem. 2011) 2 3 4 64
  2. DNA homologous recombination factor SFR1 physically and functionally interacts with estrogen receptor alpha. (PMID: 23874500) Feng Y. … Khan S. (PLoS ONE 2013) 3 4 64
  3. The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination. (PMID: 21779174) Qing Y. … Takeda S. (PLoS Genet. 2011) 2 3 64
  4. Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombination. (PMID: 20976249) Akamatsu Y. … Jasin M. (PLoS Genet. 2010) 2 3 64
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64

Products for SFR1 Gene

Sources for SFR1 Gene

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