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Aliases for SFR1 Gene

Aliases for SFR1 Gene

  • SWI5-Dependent Homologous Recombination Repair Protein 1 2 3
  • SWI5-Dependent Recombination Repair 1 2 3
  • Meiosis Protein 5 Homolog 3 4
  • C10orf78 3 4
  • MEIR5 3 4
  • MEI5 3 4
  • MEI5 Recombination Repair Protein Homolog (S. Cerevisiae) 2
  • SWI5-Dependent Recombination Repair Protein 1 3
  • MEI5 Recombination Repair Protein Homolog 3
  • Chromosome 10 Open Reading Frame 78 2
  • BA373N18.1 3

External Ids for SFR1 Gene

Previous HGNC Symbols for SFR1 Gene

  • C10orf78
  • MEIR5

Previous GeneCards Identifiers for SFR1 Gene

  • GC10P105882

Summaries for SFR1 Gene

GeneCards Summary for SFR1 Gene

SFR1 (SWI5-Dependent Homologous Recombination Repair Protein 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SFR1 Gene

  • Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFR1 Gene

Genomics for SFR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SFR1 Gene

Chromosome:
10
Start:
104,122,058 bp from pter
End:
104,126,385 bp from pter
Size:
4,328 bases
Orientation:
Plus strand

Genomic View for SFR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SFR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFR1 Gene

No data available for Regulatory Elements for SFR1 Gene

Proteins for SFR1 Gene

  • Protein details for SFR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XK3-SFR1_HUMAN
    Recommended name:
    Swi5-dependent recombination DNA repair protein 1 homolog
    Protein Accession:
    Q86XK3
    Secondary Accessions:
    • A8K569
    • B2RTV8
    • Q5JT39
    • Q5JT40
    • Q8WW47

    Protein attributes for SFR1 Gene

    Size:
    245 amino acids
    Molecular mass:
    28262 Da
    Quaternary structure:
    • Component of the SWI5-SFR1 complex. Interacts with RAD51; the interaction is weak.

    Alternative splice isoforms for SFR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SFR1 Gene

Proteomics data for SFR1 Gene at MOPED

Post-translational modifications for SFR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SFR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SFR1 Gene

Domains & Families for SFR1 Gene

Protein Domains for SFR1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SFR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86XK3

UniProtKB/Swiss-Prot:

SFR1_HUMAN :
  • Belongs to the SFR1/MEI5 family.
Family:
  • Belongs to the SFR1/MEI5 family.
genes like me logo Genes that share domains with SFR1: view

No data available for Gene Families for SFR1 Gene

Function for SFR1 Gene

Molecular function for SFR1 Gene

UniProtKB/Swiss-Prot Function:
Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination.

Gene Ontology (GO) - Molecular Function for SFR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21252223
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IDA 23874500
genes like me logo Genes that share ontologies with SFR1: view
genes like me logo Genes that share phenotypes with SFR1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SFR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SFR1 Gene

Localization for SFR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFR1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SFR1 Gene COMPARTMENTS Subcellular localization image for SFR1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for SFR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0032798 Swi5-Sfr1 complex IDA 21252223
genes like me logo Genes that share ontologies with SFR1: view

Pathways & Interactions for SFR1 Gene

SuperPathways for SFR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SFR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IMP 21252223
GO:0045893 positive regulation of transcription, DNA-templated IDA 23874500
GO:0071391 cellular response to estrogen stimulus IDA 23874500
genes like me logo Genes that share ontologies with SFR1: view

No data available for Pathways by source and SIGNOR curated interactions for SFR1 Gene

Drugs & Compounds for SFR1 Gene

No Compound Related Data Available

Transcripts for SFR1 Gene

Unigene Clusters for SFR1 Gene

SWI5-dependent recombination repair 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SFR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SFR1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1:
SP2: - -
SP3: - -
SP4:

Relevant External Links for SFR1 Gene

GeneLoc Exon Structure for
SFR1
ECgene alternative splicing isoforms for
SFR1

Expression for SFR1 Gene

mRNA expression in normal human tissues for SFR1 Gene

Protein differential expression in normal tissues from HIPED for SFR1 Gene

This gene is overexpressed in Colon muscle (64.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SFR1 Gene



SOURCE GeneReport for Unigene cluster for SFR1 Gene Hs.93667

mRNA Expression by UniProt/SwissProt for SFR1 Gene

Q86XK3-SFR1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with SFR1: view

Protein tissue co-expression partners for SFR1 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SFR1 Gene

Orthologs for SFR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SFR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SFR1 35
  • 87.24 (n)
  • 82.3 (a)
SFR1 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SFR1 35
  • 86.19 (n)
  • 78.24 (a)
SFR1 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sfr1 35
  • 68.35 (n)
  • 55.76 (a)
Sfr1 16
Sfr1 36
  • 40 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SFR1 35
  • 99.46 (n)
  • 98.78 (a)
SFR1 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sfr1 35
  • 75.31 (n)
  • 63.18 (a)
oppossum
(Monodelphis domestica)
Mammalia SFR1 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SFR1 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves SFR1 35
  • 61.49 (n)
  • 51.14 (a)
SFR1 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SFR1 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sfr1 35
  • 57.24 (n)
  • 52.68 (a)
zebrafish
(Danio rerio)
Actinopterygii sfr1 35
  • 53.44 (n)
  • 47.94 (a)
sfr1 36
  • 42 (a)
OneToOne
Species with no ortholog for SFR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SFR1 Gene

ENSEMBL:
Gene Tree for SFR1 (if available)
TreeFam:
Gene Tree for SFR1 (if available)

Paralogs for SFR1 Gene

Pseudogenes.org Pseudogenes for SFR1 Gene

genes like me logo Genes that share paralogs with SFR1: view

No data available for Paralogs for SFR1 Gene

Variants for SFR1 Gene

Sequence variations from dbSNP and Humsavar for SFR1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs12616 -- 104,126,348(+) TGATA(A/G)TCTAG utr-variant-3-prime
rs999148 -- 104,123,514(+) TTGAT(C/T)TTGCT intron-variant
rs1052001 -- 104,126,056(+) ATCCC(A/G)ATGAA utr-variant-3-prime
rs1338777 -- 104,123,637(-) TAAAG(G/T)CCTTC intron-variant
rs1933890 -- 104,124,702(+) ATAAG(A/T)GATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SFR1 Gene

Variant ID Type Subtype PubMed ID
nsv831971 CNV Gain 17160897

Variation tolerance for SFR1 Gene

Residual Variation Intolerance Score: 80.88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.58; 78.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SFR1 Gene

HapMap Linkage Disequilibrium report
SFR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFR1 Gene

Disorders for SFR1 Gene

Relevant External Links for SFR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SFR1
genes like me logo Genes that share disorders with SFR1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SFR1 Gene

Publications for SFR1 Gene

  1. The role of human SWI5-MEI5 complex in homologous recombination repair. (PMID: 21252223) Yuan J. … Chen J. (J. Biol. Chem. 2011) 2 67
  2. The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination. (PMID: 21779174) Qing Y. … Takeda S. (PLoS Genet. 2011) 2 67
  3. Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombination. (PMID: 20976249) Akamatsu Y. … Jasin M. (PLoS Genet. 2010) 2 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for SFR1 Gene

Sources for SFR1 Gene

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