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Aliases for SFR1 Gene

Aliases for SFR1 Gene

  • SWI5-Dependent Recombination Repair 1 2 3
  • Meiosis Protein 5 Homolog 3 4
  • C10orf78 3 4
  • MEIR5 3 4
  • MEI5 3 4
  • MEI5 Recombination Repair Protein Homolog (S. Cerevisiae) 2
  • Swi5-Dependent Recombination DNA Repair Protein 1 Homolog 3
  • SWI5-Dependent Recombination Repair Protein 1 3
  • MEI5 Recombination Repair Protein Homolog 3
  • Chromosome 10 Open Reading Frame 78 2
  • BA373N18.1 3
  • ZNF356 6
  • LNP94 6
  • CIZ1 6

External Ids for SFR1 Gene

Previous Symbols for SFR1 Gene

  • C10orf78
  • MEIR5

Summaries for SFR1 Gene

GeneCards Summary for SFR1 Gene

SFR1 (SWI5-Dependent Recombination Repair 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SFR1 Gene

  • Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFR1 Gene

Genomics for SFR1 Gene

Genomic Location for SFR1 Gene

104,120,301 bp from pter
104,126,385 bp from pter
6,085 bases
Plus strand

Genomic View for SFR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SFR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFR1 Gene

No data available for Regulatory Elements for SFR1 Gene

Proteins for SFR1 Gene

  • Protein details for SFR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Swi5-dependent recombination DNA repair protein 1 homolog
    Protein Accession:
    Secondary Accessions:
    • A8K569
    • B2RTV8
    • Q5JT39
    • Q5JT40
    • Q8WW47

    Protein attributes for SFR1 Gene

    245 amino acids
    Molecular mass:
    28262 Da
    Quaternary structure:
    • Component of the SWI5-SFR1 complex. Interacts with RAD51; the interaction is weak.

    Alternative splice isoforms for SFR1 Gene


neXtProt entry for SFR1 Gene

Proteomics data for SFR1 Gene at MOPED

Post-translational modifications for SFR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SFR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SFR1 Gene

Domains for SFR1 Gene

Protein Domains for SFR1 Gene



  • Belongs to the SFR1/MEI5 family.:
    • Q86XK3
genes like me logo Genes that share domains with SFR1: view

No data available for Gene Families for SFR1 Gene

Function for SFR1 Gene

Molecular function for SFR1 Gene

UniProtKB/Swiss-Prot Function: Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination.

Gene Ontology (GO) - Molecular Function for SFR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21252223
genes like me logo Genes that share ontologies with SFR1: view

Phenotypes for SFR1 Gene

GenomeRNAi human phenotypes for SFR1:
genes like me logo Genes that share phenotypes with SFR1: view

miRNA for SFR1 Gene

miRTarBase miRNAs that target SFR1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SFR1 Gene

Localization for SFR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFR1 Gene

Gene Ontology (GO) - Cellular Components for SFR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0032798 Swi5-Sfr1 complex IDA 21252223
genes like me logo Genes that share ontologies with SFR1: view

Pathways for SFR1 Gene

SuperPathways for SFR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SFR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IMP 21252223
genes like me logo Genes that share ontologies with SFR1: view

No data available for Pathways by source for SFR1 Gene

Transcripts for SFR1 Gene

Unigene Clusters for SFR1 Gene

SWI5-dependent recombination repair 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SFR1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b
SP2: - -
SP3: - -

Relevant External Links for SFR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SFR1 Gene

mRNA expression in normal human tissues for SFR1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SFR1 Gene

SOURCE GeneReport for Unigene cluster for SFR1 Gene Hs.93667

mRNA Expression by UniProt/SwissProt for SFR1 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with SFR1: view

Orthologs for SFR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SFR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SFR1 36
  • 99.46 (n)
  • 98.78 (a)
SFR1 37
  • 78 (a)
(Bos Taurus)
Mammalia SFR1 36
  • 87.24 (n)
  • 82.3 (a)
SFR1 37
  • 82 (a)
(Canis familiaris)
Mammalia SFR1 36
  • 86.19 (n)
  • 78.24 (a)
SFR1 37
  • 79 (a)
(Mus musculus)
Mammalia Sfr1 36
  • 68.35 (n)
  • 55.76 (a)
Sfr1 16
Sfr1 37
  • 40 (a)
(Monodelphis domestica)
Mammalia SFR1 37
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia SFR1 37
  • 56 (a)
(Rattus norvegicus)
Mammalia Sfr1 36
  • 75.31 (n)
  • 63.18 (a)
(Gallus gallus)
Aves SFR1 36
  • 61.49 (n)
  • 51.14 (a)
SFR1 37
  • 50 (a)
(Anolis carolinensis)
Reptilia SFR1 37
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sfr1 36
  • 57.24 (n)
  • 52.68 (a)
(Danio rerio)
Actinopterygii sfr1 36
  • 53.44 (n)
  • 47.94 (a)
sfr1 37
  • 42 (a)
Species with no ortholog for SFR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SFR1 Gene

Gene Tree for SFR1 (if available)
Gene Tree for SFR1 (if available)

Paralogs for SFR1 Gene Pseudogenes for SFR1 Gene

genes like me logo Genes that share paralogs with SFR1: view

No data available for Paralogs for SFR1 Gene

Variants for SFR1 Gene

Sequence variations from dbSNP and Humsavar for SFR1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs12616 -- 104,126,348(+) TGATA(A/G)TCTAG utr-variant-3-prime
rs999148 -- 104,123,514(+) TTGAT(C/T)TTGCT intron-variant
rs1052001 -- 104,126,056(+) ATCCC(A/G)ATGAA utr-variant-3-prime
rs1338777 -- 104,123,637(-) TAAAG(G/T)CCTTC intron-variant
rs1933890 -- 104,124,702(+) ATAAG(A/T)GATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SFR1 Gene

Variant ID Type Subtype PubMed ID
nsv831971 CNV Gain 17160897

Relevant External Links for SFR1 Gene

HapMap Linkage Disequilibrium report

Disorders for SFR1 Gene

No disorders were found for SFR1 Gene.

No data available for UniProtKB/Swiss-Prot for SFR1 Gene

Publications for SFR1 Gene

  1. The role of human SWI5-MEI5 complex in homologous recombination repair. (PMID: 21252223) Yuan J. … Chen J. (J. Biol. Chem. 2011) 2 3 4
  2. The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination. (PMID: 21779174) Qing Y. … Takeda S. (PLoS Genet. 2011) 2 3
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombination. (PMID: 20976249) Akamatsu Y. … Jasin M. (PLoS Genet. 2010) 2 3

Products for SFR1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SFR1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SFR1
    • Block miRNA regulation of SFR1 using miScript Target Protectors

    Sources for SFR1 Gene

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