Aliases for SFPQ Gene
Aliases for SFPQ Gene
- Splicing Factor Proline And Glutamine Rich 2 3 5
- Polypyrimidine Tract Binding Protein Associated 2 3
- Protein Phosphatase 1, Regulatory Subunit 140 2 3
- DNA-Binding P52/P100 Complex, 100 KDa Subunit 3 4
- Splicing Factor Proline/Glutamine-Rich 2 3
- 100 KDa DNA-Pairing Protein 3 4
- PSF 3 4
- Splicing Factor Proline/Glutamine Rich (Polypyrimidine Tract-Binding Protein-Associated) 2
- Splicing Factor Proline/Glutamine Rich (Polypyrimidine Tract Binding Protein Associated) 3
External Ids for SFPQ Gene
- HGNC: 10774
- Entrez Gene: 6421
- Ensembl: ENSG00000116560
- OMIM: 605199
- UniProtKB: P23246
Previous GeneCards Identifiers for SFPQ Gene
- GC01M035470
- GC01M034705
- GC01M035068
- GC01M035076
- GC01M035312
- GC01M035421
- GC01M035641
- GC01M033767
Summaries for SFPQ Gene
GeneCards Summary for SFPQ Gene
SFPQ (Splicing Factor Proline And Glutamine Rich) is a Protein Coding gene. Diseases associated with SFPQ include Renal Cell Carcinoma, Xp11-Associated and Adrenal Neuroblastoma. Among its related pathways are mRNA Splicing - Major Pathway and Signaling by PTK6. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is PSPC1.
UniProtKB/Swiss-Prot for SFPQ Gene
-
DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3 side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA (PubMed:25765647). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as transcriptional activator (PubMed:25765647). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5-CTGAGTC-3 in the insulin-like growth factor response element (IGFRE) and inhibits IGF-I-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (By similarity). Required for the assembly of nuclear speckles (PubMed:25765647). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).
Additional gene information for SFPQ Gene
- Monarch Initiative
- Search for SFPQ at DataMed
- Search for SFPQ at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFPQ Gene
Genomics for SFPQ Gene
GeneHancer (GH) Regulatory Elements for SFPQ Gene
- Top Transcription factor binding sites by QIAGEN in the SFPQ gene promoter:
Regulatory Element Products
Genomic Locations for SFPQ Gene
- chr1:35,176,378-35,193,158
- (GRCh38/hg38)
- Size:
- 16,781 bases
- Orientation:
- Minus strand
- chr1:35,641,979-35,658,749
- (GRCh37/hg19)
Genomic View for SFPQ Gene
- Cytogenetic band:
-
- 1p34.3 by Ensembl
- 1p34.3 by Entrez Gene
- 1p34.3 by HGNC


RefSeq DNA sequence for SFPQ Gene
Proteins for SFPQ Gene
-
Protein details for SFPQ Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P23246-SFPQ_HUMAN
- Recommended name:
- Splicing factor, proline- and glutamine-rich
- Protein Accession:
- P23246
- P30808
- Q5SZ71
Protein attributes for SFPQ Gene
- Size:
- 707 amino acids
- Molecular mass:
- 76149 Da
- Quaternary structure:
-
- Heterodimer with NONO (PubMed:25765647). Monomer and component of the SFPQ-NONO complex, which is probably a heterotetramer of two 52 kDa (NONO) and two 100 kDa (SFPQ) subunits (PubMed:8439294, PubMed:25765647). The coiled coil domain mediates interaction with NONO, and can also mediate formation of long, linear homooligomers (in vitro) (PubMed:25765647). SFPQ is a component of spliceosome and U5.4/6 snRNP complexes (PubMed:9409622, PubMed:8045264, PubMed:12403470). Interacts with SNRPA/U1A (PubMed:9848648). Component of a snRNP-free complex with SNRPA/U1A (PubMed:9848648). Part of complex consisting of SFPQ, NONO and MATR3 (PubMed:11525732). Interacts with polypyrimidine tract-binding protein 1/PTB (PubMed:10653975). Part of a complex consisting of SFPQ, NONO and NR5A1 (PubMed:11897684). Interacts with RXRA, probably THRA, and SIN3A (PubMed:11259580). Interacts with TOP1 (PubMed:9756848). Part of a complex consisting of SFPQ, NONO and TOP1 (PubMed:9756848). Interacts with SNRNP70 in apoptotic cells (PubMed:11514619). Interacts with PSPC1. Interacts with RNF43 (PubMed:18655028). Interacts with PITX3 and NR4A2/NURR1 (By similarity). Interacts with PTK6 (PubMed:19439179). Interacts with THRAP3; the interaction is dependent on SFPQ phosphorylation at Thr-687 and inhibits binding of SFPQ to a ESS1 exonic splicing silencer element-containing RNA (PubMed:20932480). The large PER complex involved in the histone deacetylation is composed of at least HDAC1, PER2, SFPQ and SIN3A. Interacts with PER1 and PER2 (By similarity). Interacts with PQBP1 (PubMed:21933836).
- (Microbial infection) Interacts with M.tuberculosis protein Rv3654c, which probably leads to the cleavage of PSF, diminishes the level of caspase-8 in macrophages and suppresses macrophage apoptosis by blocking the extrinsic pathway. Part of the HDP-RNP complex composed of at least HEXIM1, PRKDC, XRCC5, XRCC6, paraspeckle proteins (SFPQ, NONO, PSPC1, RBM14, and MATR3) and NEAT1 RNA.
Protein Expression for SFPQ Gene
Post-translational modifications for SFPQ Gene
- Phosphorylated on multiple serine and threonine residues during apoptosis. In vitro phosphorylated by PKC. Phosphorylation stimulates binding to DNA and D-loop formation, but inhibits binding to RNA. Phosphorylation of C-terminal tyrosines promotes its cytoplasmic localization, impaired its binding to polypyrimidine RNA and led to cell cycle arrest. In resting T-cells is phosphorylated at Thr-687 by GSK3B which is proposed to promote association with THRAP and to prevent binding to PTPRC/CD45 pre-mRNA; T-cell activation leads to reduced phosphorylation at Thr-687.
- The N-terminus is blocked.
- Ubiquitination at isoforms=2279, posLast=319319, isoforms=2330, isoforms=2338, and isoforms=2413
Other Protein References for SFPQ Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for SFPQ
- Novus Biologicals Antibodies for SFPQ
-
Abcam antibodies for SFPQ
- Invitrogen Antibodies for SFPQ
- Search GeneTex for Antibodies for SFPQ
-
Santa Cruz Biotechnology (SCBT) Antibodies for SFPQ
Protein Products
-
OriGene Purified Proteins for SFPQ
- Search Origene for MassSpec and Protein Over-expression Lysates for SFPQ
- Origene Custom Protein Services for SFPQ
- antibodies-online: Search results for available SFPQ related products ranked by validation data
- Search GeneTex for Proteins for SFPQ
Assay Products
- antibodies-online: Search results for available SFPQ related products ranked by validation data
No data available for DME Specific Peptides for SFPQ Gene
Domains & Families for SFPQ Gene
Gene Families for SFPQ Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for SFPQ Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SFPQ Gene
Graphical View of Domain Structure for InterPro Entry
P23246UniProtKB/Swiss-Prot:
SFPQ_HUMAN :- The coiled coil domain mediates interaction with NONO, and can also mediate formation of long, linear homooligomers (in vitro). The coiled coil domain is required for optimal DNA binding, and optimal transcription activation.
- Domain:
-
- The coiled coil domain mediates interaction with NONO, and can also mediate formation of long, linear homooligomers (in vitro). The coiled coil domain is required for optimal DNA binding, and optimal transcription activation.
Function for SFPQ Gene
Molecular function for SFPQ Gene
- GENATLAS Biochemistry:
- splicing factor proline/glutamine rich,widely expressed,interacting with polypyrimidine tract-binding protein PTB,essential factor in pre mRNA required early in spliceosome formation
- UniProtKB/Swiss-Prot Function:
- DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3 side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA (PubMed:25765647). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as transcriptional activator (PubMed:25765647). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5-CTGAGTC-3 in the insulin-like growth factor response element (IGFRE) and inhibits IGF-I-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (By similarity). Required for the assembly of nuclear speckles (PubMed:25765647). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).
Phenotypes From GWAS Catalog for SFPQ Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000976 | transcription regulatory region sequence-specific DNA binding | IEA,ISS | -- |
GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | IEA,ISS | -- |
GO:0001047 | core promoter binding | ISS,IEA | -- |
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003677 | DNA binding | IDA,IEA | 25765647 |
Phenotypes for SFPQ Gene
- MGI mutant phenotypes for SFPQ:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SFPQ:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Synthetic lethal with Ras
- Lamellipodia cells
- Increased transferrin (TF) endocytosis
- Decreased POU5F1-GFP protein expression
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased G1 DNA content
- Decreased IL-8 secretion
- Increased transcriptional activity
- Increased HPV18 LCR reporter activity
- Weakly decreased NFAT1-GFP nuclear translocation
- Decreased cell number
- Increased Nanog expression
- Decreased OCT4 protein expression
- Decreased NANOG protein expression
- Decreased BPV1 E2 protein expression
- Increased shRNA abundance with PLX4720
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SFPQ
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SFPQ gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SFPQ gene
- Search ViGene Biosciences for SFPQ
CRISPR Products
-
OriGene CRISPR knockouts for SFPQ
- genomics-online: gRNA clones - Search results for 87 available SFPQ gene related products
- Overview of 87 available SFPQ gene related products
- Applied Biological Materials CRISPR for SFPQ
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SFPQ
- GenScript: Design CRISPR guide RNA sequences for SFPQ
miRNA for SFPQ Gene
- miRTarBase miRNAs that target SFPQ
-
- hsa-mir-141-3p (MIRT002309)
- hsa-mir-29b-3p (MIRT002310)
- hsa-mir-1229-3p (MIRT036338)
- hsa-mir-615-3p (MIRT040035)
- hsa-mir-92b-3p (MIRT040650)
- hsa-mir-193b-3p (MIRT041361)
- hsa-mir-331-3p (MIRT043279)
- hsa-mir-10a-5p (MIRT047727)
- hsa-mir-218-5p (MIRT439658)
- hsa-mir-498 (MIRT554364)
- hsa-mir-4465 (MIRT554365)
- hsa-mir-26b-5p (MIRT554366)
- hsa-mir-26a-5p (MIRT554367)
- hsa-mir-1297 (MIRT554368)
- hsa-mir-1296-5p (MIRT554369)
- hsa-mir-6508-3p (MIRT554370)
- hsa-mir-5697 (MIRT554371)
- hsa-mir-4512 (MIRT554372)
- hsa-mir-7160-3p (MIRT554373)
- hsa-mir-6895-5p (MIRT554374)
- hsa-mir-5694 (MIRT554375)
- hsa-mir-383-5p (MIRT554376)
miRNA Products
- Search ViGene Biosciences for SFPQ
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SFPQ
- Browse OriGene Inhibitory RNA Products For SFPQ
- genomics-online: shRNA clones - Search results for 87 available SFPQ gene related products
- Overview of 87 available SFPQ gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SFPQ gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SFPQ
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SFPQ
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SFPQ
- Applied Biological Materials Clones for SFPQ
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for SFPQ gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SFPQ gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SFPQ gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SFPQ Gene
Localization for SFPQ Gene
Subcellular locations from UniProtKB/Swiss-Prot for SFPQ Gene
- Nucleus speckle. Nucleus matrix. Cytoplasm. Note=Predominantly in nuclear matrix. {ECO:0000269 PubMed:19439179}.
- Nucleoplasm (4)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000785 | chromatin | IDA | 16731528 |
GO:0005634 | nucleus | IDA | 15790595 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0016363 | nuclear matrix | IDA | 19874820 |
Pathways & Interactions for SFPQ Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by PTK6 | ||
2 | Signaling by GPCR | ||
3 | Development NOTCH1-mediated pathway for NF-KB activity modulation | ||
4 | Circadian rythm related genes | ||
5 | mRNA Splicing - Major Pathway |
.41
|
Pathways by source for SFPQ Gene
2 BioSystems pathways for SFPQ Gene
3 Reactome pathways for SFPQ Gene
1 GeneGo (Thomson Reuters) pathway for SFPQ Gene
Interacting Proteins for SFPQ Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP | 22783022 |
GO:0000380 | alternative mRNA splicing, via spliceosome | IMP | 19874820 |
GO:0000724 | double-strand break repair via homologous recombination | IMP | 20813759 |
GO:0002218 | activation of innate immune response | IDA | 28712728 |
GO:0002376 | immune system process | IEA | -- |
Transcripts for SFPQ Gene
mRNA/cDNA for SFPQ Gene
- (7) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (810) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SFPQ Gene
CRISPR Products
-
OriGene CRISPR knockouts for SFPQ
- genomics-online: gRNA clones - Search results for 87 available SFPQ gene related products
- Overview of 87 available SFPQ gene related products
- Applied Biological Materials CRISPR for SFPQ
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SFPQ
- GenScript: Design CRISPR guide RNA sequences for SFPQ
miRNA Products
- Search ViGene Biosciences for SFPQ
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SFPQ
- Browse OriGene Inhibitory RNA Products For SFPQ
- genomics-online: shRNA clones - Search results for 87 available SFPQ gene related products
- Overview of 87 available SFPQ gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SFPQ gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SFPQ
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SFPQ
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SFPQ
- Applied Biological Materials Clones for SFPQ
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||
SP4: |
Expression for SFPQ Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Gonad (Reproductive System)
- Primordial Germ Cells Primitive Gonad
- Brain (Nervous System)
- Intermediate Mesoderm (Gastrulation Derivatives)
- Neural Tube (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Pancreas (Endocrine System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SFPQ Gene
NURSA nuclear receptor signaling pathways regulating expression of SFPQ Gene:
SFPQSOURCE GeneReport for Unigene cluster for SFPQ Gene:
Hs.355934Evidence on tissue expression from TISSUES for SFPQ Gene
- Nervous system(4.8)
- Liver(4.4)
- Muscle(4.4)
- Pancreas(3.6)
- Lung(3.1)
- Kidney(2.7)
- Skin(2.7)
- Intestine(2.6)
- Bone marrow(2.5)
- Adrenal gland(2.4)
- Spleen(2.4)
- Eye(2.3)
- Heart(2.2)
- Lymph node(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for SFPQ Gene
- mesoderm
- urinary
- kidney
Primer Products
-
OriGene qPCR primer pairs for SFPQ
-
OriGene qPCR primer pairs and template standards for SFPQ
- genomics-online: primer clones - Search results for 87 available SFPQ gene related products
- Overview of 87 available SFPQ gene related products
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SFPQ Gene
Orthologs for SFPQ Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | SFPQ 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
SFPQ 33 |
|
||||
-- 34 |
|
OneToMany | |||
-- 34 |
|
OneToMany | |||
platypus (Ornithorhynchus anatinus) |
Mammalia | SFPQ 34 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | SFPQ 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Sfpq 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Sfpq 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | SFPQ 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | SFPQ 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | SFPQ 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.1954 33 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.1807 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | sfpq 33 34 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | nonA-l 34 |
|
ManyToMany | |
nonA 34 |
|
ManyToMany | |||
worm (Caenorhabditis elegans) |
Secernentea | nono-1 34 |
|
OneToMany | |
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for SFPQ was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SFPQ Gene
(3) SIMAP similar genes for SFPQ Gene using alignment to 6 proteins:
Pseudogenes.org Pseudogenes for SFPQ Gene
Variants for SFPQ Gene
SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000109361 | -- | 35,181,081(-) | C/T | 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant | |
rs1000112358 | -- | 35,185,214(-) | G/T | intron_variant | |
rs1000152345 | -- | 35,183,735(-) | A/T | 3_prime_UTR_variant, intron_variant | |
rs1000373238 | -- | 35,183,953(-) | T/A | 3_prime_UTR_variant, intron_variant | |
rs1000477142 | -- | 35,178,228(-) | T/C | 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant |
Additional Variant Information for SFPQ Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFPQ Gene
Disorders for SFPQ Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
renal cell carcinoma, xp11-associated |
|
|
adrenal neuroblastoma |
|
|
UniProtKB/Swiss-Prot
SFPQ_HUMAN- Note=A chromosomal aberration involving SFPQ may be a cause of papillary renal cell carcinoma (PRCC). Translocation t(X;1)(p11.2;p34) with TFE3.
Additional Disease Information for SFPQ
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for SFPQ Gene
Publications for SFPQ Gene
- Cloning and characterization of PSF, a novel pre-mRNA splicing factor. (PMID: 8449401) Patton JG … Nadal-Ginard B (Genes & development 1993) 2 3 4 22 58
- The PSF.p54nrb complex is a novel Mnk substrate that binds the mRNA for tumor necrosis factor alpha. (PMID: 17965020) Buxadé M … Proud CG (The Journal of biological chemistry 2008) 3 4 22 58
- Proteomic identification of a PSF/p54nrb heterodimer as RNF43 oncoprotein-interacting proteins. (PMID: 18655028) Miyamoto K … Sugiura T (Proteomics 2008) 3 4 22 58
- NPM/ALK binds and phosphorylates the RNA/DNA-binding protein PSF in anaplastic large-cell lymphoma. (PMID: 17537995) Galietta A … Gambacorti-Passerini C (Blood 2007) 3 4 22 58
- Identification of the polypyrimidine tract binding protein-associated splicing factor.p54(nrb) complex as a candidate DNA double-strand break rejoining factor. (PMID: 15590677) Bladen CL … Dynan WS (The Journal of biological chemistry 2005) 3 4 22 58
Products for SFPQ Gene
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- Invitrogen Antibodies for SFPQ
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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- VectorBuilder custom plasmid, inducible vectors for SFPQ
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SFPQ
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SFPQ
- antibodies-online: Search results for 77 available SFPQ Antibodies ranked by validation data
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- ViGene Biosciences adenoviral particle packaged cDNA for SFPQ gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for SFPQ
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- genomics-online: cdna clones - Search results for 87 available SFPQ gene related products
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- Overview of 87 available SFPQ gene related products
Sources for SFPQ Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
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- (114) diseasecard
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- (139) VectorBuilder
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- (145) dbSUPER
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- (150) Human Protein Atlas
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- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
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- (157) EPDnew