Aliases for SFPQ Gene
Aliases for SFPQ Gene
- Splicing Factor Proline/Glutamine-Rich 2 3 5
- Splicing Factor Proline/Glutamine Rich (Polypyrimidine Tract-Binding Protein-Associated) 2 3
- Polypyrimidine Tract-Binding Protein-Associated-Splicing Factor 3 4
- Polypyrimidine Tract Binding Protein Associated 2 3
- DNA-Binding P52/P100 Complex, 100 KDa Subunit 3 4
- PTB-Associated-Splicing Factor 3 4
- 100 KDa DNA-Pairing Protein 3 4
- PSF 3 4
- Splicing Factor Proline/Glutamine Rich (Polypyrimidine Tract Binding Protein Associated) 3
External Ids for SFPQ Gene
- HGNC: 10774
- Entrez Gene: 6421
- Ensembl: ENSG00000116560
- OMIM: 605199
- UniProtKB: P23246
Previous GeneCards Identifiers for SFPQ Gene
- GC01M035470
- GC01M034705
- GC01M035068
- GC01M035076
- GC01M035312
- GC01M035421
- GC01M035641
- GC01M033767
Summaries for SFPQ Gene
GeneCards Summary for SFPQ Gene
SFPQ (Splicing Factor Proline/Glutamine-Rich) is a Protein Coding gene. Diseases associated with SFPQ include Translocation Renal Cell Carcinoma and Adrenal Neuroblastoma. Among its related pathways are Signaling by PTK6 and mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is NONO.
UniProtKB/Swiss-Prot for SFPQ Gene
-
DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3 side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5-CTGAGTC-3 in the insulin-like growth factor response element (IGFRE) and inhibits IGF-I-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation.
No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFPQ Gene
Genomics for SFPQ Gene
Regulatory Elements for SFPQ Gene
Enhancers for SFPQ Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around SFPQ on UCSC Golden Path with GeneCards custom track
Promoters for SFPQ Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around SFPQ on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the SFPQ gene promoter:
Regulatory Element Products
Genomic Location for SFPQ Gene
- Chromosome:
- 1
- Start:
- 35,176,378 bp from pter
- End:
- 35,193,158 bp from pter
- Size:
- 16,781 bases
- Orientation:
- Minus strand
Genomic View for SFPQ Gene
Genes around SFPQ on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p34.3 by Ensembl
- 1p34.3 by Entrez Gene
- 1p34.3 by HGNC
SFPQ Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SFPQ Gene
Proteins for SFPQ Gene
-
Protein details for SFPQ Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P23246-SFPQ_HUMAN
- Recommended name:
- Splicing factor, proline- and glutamine-rich
- Protein Accession:
- P23246
- P30808
- Q5SZ71
Protein attributes for SFPQ Gene
- Size:
- 707 amino acids
- Molecular mass:
- 76149 Da
- Quaternary structure:
-
- Monomer and component of the SFPQ-NONO complex, which is probably a heterotetramer of two 52 kDa (NONO) and two 100 kDa (SFPQ) subunits. SFPQ is a component of spliceosome and U5.4/6 snRNP complexes. Interacts with SNRPA/U1A. Component of a snRNP-free complex with SNRPA/U1A. Part of complex consisting of SFPQ, NONO and MATR3. Interacts with polypyrimidine tract-binding protein 1/PTB. Part of a complex consisting of SFPQ, NONO and NR5A1. Interacts with RXRA, probably THRA, and SIN3A. Interacts with TOP1. Part of a complex consisting of SFPQ, NONO and TOP1. Interacts with SNRNP70 in apoptotic cells. Interacts with PSPC1. Interacts with RNF43. Interacts with PITX3 and NR4A2/NURR1. Interacts with PTK6. Interacts with THRAP3; the interaction is dependent on SFPQ phosphorylation at Thr-687 and inhibits binding of SFPQ to a ESS1 exonic splicing silencer element-containing RNA. The large PER complex involved in the histone deacetylation is composed of at least HDAC1, PER2, SFPQ and SIN3A. Interacts with PER1 and PER2.
Protein Expression for SFPQ Gene
Post-translational modifications for SFPQ Gene
- Phosphorylated on multiple serine and threonine residues during apoptosis. In vitro phosphorylated by PKC. Phosphorylation stimulates binding to DNA and D-loop formation, but inhibits binding to RNA. Phosphorylation of C-terminal tyrosines promotes its cytoplasmic localization, impaired its binding to polypyrimidine RNA and led to cell cycle arrest. In resting T-cells is phosphorylated at Thr-687 by GSK3B which is proposed to promote association with THRAP and to prevent binding to PTPRC/CD45 pre-mRNA; T-cell activation leads to reduced phosphorylation at Thr-687.
- The N-terminus is blocked.
- Ubiquitination at Lys 279, Lys 319, Lys 330, Lys 338, and Lys 413
- Modification sites at PhosphoSitePlus
Other Protein References for SFPQ Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for SFPQ
- Invitrogen Antibodies for SFPQ
- antibodies-online Antibodies for SFPQ: See all 60
- GeneTex SFPQ antibody for SFPQ
-
Santa Cruz Biotechnology (SCBT) Antibodies for SFPQ
Protein Products
-
OriGene Purified Proteins for SFPQ
- Search Origene for MassSpec and Protein Over-expression Lysates for SFPQ
- Origene Custom Protein Services for SFPQ
- Search GeneTex for Proteins for SFPQ
Assay Products
No data available for DME Specific Peptides for SFPQ Gene
Domains & Families for SFPQ Gene
Gene Families for SFPQ Gene
Protein Domains for SFPQ Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SFPQ Gene
Graphical View of Domain Structure for InterPro Entry
P23246- Domain:
-
- Contains 2 RRM (RNA recognition motif) domains.
Function for SFPQ Gene
Molecular function for SFPQ Gene
- GENATLAS Biochemistry:
- splicing factor proline/glutamine rich,widely expressed,interacting with polypyrimidine tract-binding protein PTB,essential factor in pre mRNA required early in spliceosome formation
- UniProtKB/Swiss-Prot Function:
- DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3 side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5-CTGAGTC-3 in the insulin-like growth factor response element (IGFRE) and inhibits IGF-I-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0005515 | protein binding | IEA,IPI | 9848648 |
| GO:0044212 | transcription regulatory region DNA binding | IDA | 16731528 |
Phenotypes for SFPQ Gene
- MGI mutant phenotypes for SFPQ:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SFPQ:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Synthetic lethal with Ras
- Lamellipodia cells
- Increased transferrin (TF) endocytosis
- Decreased POU5F1-GFP protein expression
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased G1 DNA content
- Increased transcriptional activity
- Increased HPV18 LCR reporter activity
- Weakly decreased NFAT1-GFP nuclear translocation
- Decreased cell number
- Decreased OCT4 protein expression
- Decreased NANOG protein expression
- Decreased BPV1 E2 protein expression
- Increased shRNA abundance with PLX4720
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for SFPQ gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SFPQ gene
- Search ViGene Biosciences for SFPQ
CRISPR Products
-
OriGene CRISPR knockouts for SFPQ
-
Santa Cruz Biotechnology (SCBT) CRISPR for SFPQ
- GenScript: Design CRISPR guide RNA sequences for SFPQ
miRNA for SFPQ Gene
- miRTarBase miRNAs that target SFPQ
-
- hsa-mir-141-3p (MIRT002309)
- hsa-mir-29b-3p (MIRT002310)
- hsa-mir-1229-3p (MIRT036338)
- hsa-mir-615-3p (MIRT040035)
- hsa-mir-92b-3p (MIRT040650)
- hsa-mir-193b-3p (MIRT041361)
- hsa-mir-331-3p (MIRT043279)
- hsa-mir-10a-5p (MIRT047727)
- hsa-mir-218-5p (MIRT439658)
- hsa-mir-498 (MIRT554364)
- hsa-mir-4465 (MIRT554365)
- hsa-mir-26b-5p (MIRT554366)
- hsa-mir-26a-5p (MIRT554367)
- hsa-mir-1297 (MIRT554368)
- hsa-mir-1296-5p (MIRT554369)
- hsa-mir-6508-3p (MIRT554370)
- hsa-mir-5697 (MIRT554371)
- hsa-mir-4512 (MIRT554372)
- hsa-mir-7160-3p (MIRT554373)
- hsa-mir-6895-5p (MIRT554374)
- hsa-mir-5694 (MIRT554375)
- hsa-mir-383-5p (MIRT554376)
miRNA Products
- Search ViGene Biosciences for SFPQ
Clone Products
- OriGene clones in human for SFPQ
- OriGene ORF clones in human,mouse,rat for SFPQ
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for SFPQ
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for SFPQ gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SFPQ gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SFPQ gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SFPQ Gene
Localization for SFPQ Gene
Subcellular locations from UniProtKB/Swiss-Prot for SFPQ Gene
- Nucleus matrix. Cytoplasm. Note=Predominantly in nuclear matrix. {ECO:0000269 PubMed:19439179}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| mitochondrion | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0042382 | paraspeckles | IEA,IDA | 19874820 |
| GO:0090575 | RNA polymerase II transcription factor complex | IEA,ISS | -- |
Pathways & Interactions for SFPQ Gene
More details on SuperPathways for SFPQ| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by PTK6 | ||
| 2 | Signaling by GPCR | ||
| 3 | Development NOTCH1-mediated pathway for NF-KB activity modulation | ||
| 4 | mRNA Splicing - Major Pathway |
.41
|
Pathways by source for SFPQ Gene
1 BioSystems pathway for SFPQ Gene
3 Reactome pathways for SFPQ Gene
1 GeneGo (Thomson Reuters) pathway for SFPQ Gene
Interacting Proteins for SFPQ Gene
Selected Interacting proteins:
P23246-SFPQ_HUMAN
ENSP00000349748
for SFPQ Gene via
MINT
STRING
UniProtKB
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IMP | 22783022 |
| GO:0000380 | alternative mRNA splicing, via spliceosome | IMP | 19874820 |
| GO:0006974 | cellular response to DNA damage stimulus | IEA | -- |
| GO:0042752 | regulation of circadian rhythm | IEA,ISS | -- |
| GO:0045876 | positive regulation of sister chromatid cohesion | IEA | -- |
Drugs & Compounds for SFPQ Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| cyclic amp | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for SFPQ Gene
mRNA/cDNA for SFPQ Gene
- (5) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (810) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SFPQ Gene
CRISPR Products
-
OriGene CRISPR knockouts for SFPQ
-
Santa Cruz Biotechnology (SCBT) CRISPR for SFPQ
- GenScript: Design CRISPR guide RNA sequences for SFPQ
miRNA Products
- Search ViGene Biosciences for SFPQ
Clone Products
- OriGene clones in human for SFPQ
- OriGene ORF clones in human,mouse,rat for SFPQ
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for SFPQ
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||
| SP4: |
Expression for SFPQ Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Gonad (Reproductive System)
- Primordial Germ Cells Primitive Gonad
- Brain (Nervous System)
- Intermediate Mesoderm (Gastrulation Derivatives)
- Neural Tube (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Pancreas (Endocrine System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Lymph node (10.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SFPQ Gene
SOURCE GeneReport for Unigene cluster for SFPQ Gene Hs.355934
- Elite partner
Primer Products
-
OriGene qPCR primer pairs and template standards for SFPQ
-
OriGene qPCR primer pairs for SFPQ
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SFPQ Gene
Orthologs for SFPQ Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | SFPQ 35 |
|
||
| SFPQ 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | SFPQ 35 |
|
||
| -- 36 |
|
OneToMany | |||
| -- 36 |
|
OneToMany | |||
| -- 36 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Sfpq 35 |
|
||
| Sfpq 16 |
|
||||
| Sfpq 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | SFPQ 35 |
|
||
| SFPQ 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Sfpq 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SFPQ 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | SFPQ 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SFPQ 35 |
|
||
| SFPQ 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | SFPQ 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.1954 35 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.1807 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | sfpq 35 |
|
||
| sfpq 36 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | nonA 36 |
|
ManyToMany | |
| nonA-l 36 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | nono-1 36 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToMany |
- Species with no ortholog for SFPQ:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SFPQ Gene
(3) SIMAP similar genes for SFPQ Gene using alignment to 6 proteins:
Pseudogenes.org Pseudogenes for SFPQ Gene
Variants for SFPQ Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs11413 | -- | 35,178,261(-) | TTAAA(A/G)AAAAT | intron-variant | |
| rs14848 | -- | 35,177,996(-) | TCATT(A/C)ACATG | utr-variant-3-prime | |
| rs1136726 | -- | 35,177,343(-) | AAGCC(A/C/G)CAAGC | utr-variant-3-prime | |
| rs1053946 | -- | 35,183,155(-) | TGCTA(C/T)TTCTG | intron-variant, downstream-variant-500B, utr-variant-3-prime | |
| rs1053947 | -- | 35,182,952(-) | CACCA(A/T)AAAGG | intron-variant, utr-variant-3-prime |
Residual Variation Intolerance Score:
15.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.39;
27.39% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for SFPQ Gene
- Human Gene Mutation Database (HGMD)
- SFPQ
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFPQ Gene
Disorders for SFPQ Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| translocation renal cell carcinoma |
|
|
| adrenal neuroblastoma |
|
|
| pick disease |
|
|
| renal cell carcinoma |
|
|
Search SFPQ in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
SFPQ_HUMAN- Note=A chromosomal aberration involving SFPQ may be a cause of papillary renal cell carcinoma (PRCC). Translocation t(X;1)(p11.2;p34) with TFE3.
Relevant External Links for SFPQ
No data available for Genatlas for SFPQ Gene
Publications for SFPQ Gene
- Cloning and characterization of PSF, a novel pre-mRNA splicing factor. (PMID: 8449401) Patton J.G. … Nadal-Ginard B. (Genes Dev. 1993) 2 3 4 23 67
- hnRNP M interacts with PSF and p54(nrb) and co-localizes within defined nuclear structures. (PMID: 19874820) Marko M. … Guialis A. (Exp. Cell Res. 2010) 3 23
- Interplay between polypyrimidine tract binding protein-associated splicing factor and human myometrial progesterone receptors. (PMID: 19339282) Tyson-Capper A.J. … Robson S.C. (J. Mol. Endocrinol. 2009) 3 23
- Novel roles of hakai in cell proliferation and oncogenesis. (PMID: 19535458) Figueroa A. … Fujita Y. (Mol. Biol. Cell 2009) 3 23
- The PSF.p54nrb complex is a novel Mnk substrate that binds the mRNA for tumor necrosis factor alpha. (PMID: 17965020) Buxade M. … Proud C.G. (J. Biol. Chem. 2008) 3 23
Products for SFPQ Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for SFPQ
- Search Origene for MassSpec and Protein Over-expression Lysates for SFPQ
- Origene Custom Protein Services for SFPQ
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for SFPQ
- Browse OriGene Inhibitory RNA Products For SFPQ
- OriGene qPCR primer pairs for SFPQ
- OriGene qPCR primer pairs and template standards for SFPQ
- OriGene CRISPR knockouts for SFPQ
- OriGene clones in human for SFPQ
- OriGene ORF clones in human,mouse,rat for SFPQ
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for SFPQ
- GenScript Custom Assay Services for SFPQ
- GenScript Custom overexpressing Cell Line Services for SFPQ
- GenScript: Design CRISPR guide RNA sequences for SFPQ
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for SFPQ
- Novus Biologicals Antibodies for SFPQ
- Novus Biologicals proteins and lysates for SFPQ
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for SFPQ gene
- ViGene Biosciences lentiviral particle packaged cDNA for SFPQ gene
- ViGene Biosciences lentiviral particle packaged cDNA for SFPQ gene
- ViGene Biosciences ready-to-package AAV shRNAs for SFPQ gene
- ViGene Biosciences ready-to-package AAV shRNAs for SFPQ gene
- ViGene Biosciences ready-to-package AAV shRNAs for SFPQ gene
- Search ViGene Biosciences for SFPQ
- Search ViGene Biosciences for SFPQ
- Santa Cruz Biotechnology (SCBT) Antibodies for SFPQ
- Search Santa Cruz Biotechnology (SCBT) for SFPQ siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SFPQ
Sources for SFPQ Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon