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Aliases for SFN Gene

Aliases for SFN Gene

  • Stratifin 2 3 4
  • Epithelial Cell Marker Protein 1 3 4
  • 14-3-3 Sigma 2 3
  • 14-3-3 Protein Sigma 3
  • YWHAS 3
  • HME1 4

External Ids for SFN Gene

Previous GeneCards Identifiers for SFN Gene

  • GC01M028401
  • GC01P026221
  • GC01P026422
  • GC01P026795
  • GC01P026796
  • GC01P027062
  • GC01P027189
  • GC01P025443

Summaries for SFN Gene

GeneCards Summary for SFN Gene

SFN (Stratifin) is a Protein Coding gene. Diseases associated with SFN include limbal stem cell deficiency and bladder squamous cell carcinoma. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Glucocorticoid receptor regulatory network. GO annotations related to this gene include protein kinase binding and phosphoprotein binding. An important paralog of this gene is YWHAZ.

UniProtKB/Swiss-Prot for SFN Gene

  • Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.

  • p53-regulated inhibitor of G2/M progression.

Gene Wiki entry for SFN Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFN Gene

Genomics for SFN Gene

Regulatory Elements for SFN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SFN Gene

Start:
26,863,138 bp from pter
End:
26,864,457 bp from pter
Size:
1,320 bases
Orientation:
Plus strand

Genomic View for SFN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SFN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFN Gene

Proteins for SFN Gene

  • Protein details for SFN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31947-1433S_HUMAN
    Recommended name:
    14-3-3 protein sigma
    Protein Accession:
    P31947
    Secondary Accessions:
    • Q6FH30
    • Q6FH51
    • Q96DH0

    Protein attributes for SFN Gene

    Size:
    248 amino acids
    Molecular mass:
    27774 Da
    Quaternary structure:
    • Homodimer. Interacts with KRT17 and SAMSN1 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with GAB2. Interacts with SRPK2. Interacts with COPS6. Interacts with RFWD2; this interaction leads to proteasomal degradation.

    Three dimensional structures from OCA and Proteopedia for SFN Gene

    Alternative splice isoforms for SFN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SFN Gene

Proteomics data for SFN Gene at MOPED

Post-translational modifications for SFN Gene

  • Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation.
  • Ubiquitination at Lys11, Lys49, Lys122, and Lys124
  • Modification sites at PhosphoSitePlus

Other Protein References for SFN Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SFN Gene

Domains for SFN Gene

Protein Domains for SFN Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SFN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P31947

UniProtKB/Swiss-Prot:

1433S_HUMAN :
  • P31947
Family:
  • Belongs to the 14-3-3 family.
genes like me logo Genes that share domains with SFN: view

No data available for Gene Families for SFN Gene

Function for SFN Gene

Molecular function for SFN Gene

UniProtKB/Swiss-Prot Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
UniProtKB/Swiss-Prot Function: p53-regulated inhibitor of G2/M progression.

Gene Ontology (GO) - Molecular Function for SFN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11574543
GO:0008426 protein kinase C inhibitor activity TAS 8515476
GO:0019901 protein kinase binding IEA --
GO:0019904 protein domain specific binding IEA --
GO:0051219 phosphoprotein binding IEA --
genes like me logo Genes that share ontologies with SFN: view
genes like me logo Genes that share phenotypes with SFN: view

Animal Models for SFN Gene

MGI Knock Outs for SFN:

Animal Model Products

miRNA for SFN Gene

miRTarBase miRNAs that target SFN

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SFN Gene

Localization for SFN Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFN Gene

Cytoplasm. Nucleus. Secreted. Note=May be secreted by a non-classical secretory pathway.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SFN Gene COMPARTMENTS Subcellular localization image for SFN gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 3
plasma membrane 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for SFN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 8515476
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0030659 cytoplasmic vesicle membrane TAS --
genes like me logo Genes that share ontologies with SFN: view

Pathways for SFN Gene

genes like me logo Genes that share pathways with SFN: view

PCR Array Products

Gene Ontology (GO) - Biological Process for SFN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0001836 release of cytochrome c from mitochondria IDA 11574543
GO:0003334 keratinocyte development IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006469 negative regulation of protein kinase activity TAS 8515476
genes like me logo Genes that share ontologies with SFN: view

Compounds for SFN Gene

(3) Novoseek inferred chemical compound relationships for SFN Gene

Compound -log(P) Hits PubMed IDs
fatty acid 4.93 2
calcium 0 2
superoxide 0 1
genes like me logo Genes that share compounds with SFN: view

Transcripts for SFN Gene

mRNA/cDNA for SFN Gene

(348) Selected AceView cDNA sequences:
(9) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SFN Gene

Stratifin:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SFN

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SFN Gene

No ASD Table

Relevant External Links for SFN Gene

GeneLoc Exon Structure for
SFN
ECgene alternative splicing isoforms for
SFN

Expression for SFN Gene

mRNA expression in normal human tissues for SFN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SFN Gene

This gene is overexpressed in Esophagus - Mucosa (17.9), Skin - Not Sun Exposed (Suprapubic) (10.4), Skin - Sun Exposed (Lower leg) (7.8), Minor Salivary Gland (5.6), and Vagina (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SFN Gene

SOURCE GeneReport for Unigene cluster for SFN Gene Hs.523718

mRNA Expression by UniProt/SwissProt for SFN Gene

P31947-1433S_HUMAN
Tissue specificity: Present mainly in tissues enriched in stratified squamous keratinizing epithelium
genes like me logo Genes that share expressions with SFN: view

In Situ Assay Products

Orthologs for SFN Gene

This gene was present in the common ancestor of animals.

Orthologs for SFN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SFN 35
  • 99.73 (n)
  • 100 (a)
SFN 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SFN 35
  • 92.17 (n)
  • 97.86 (a)
SFN 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SFN 35
  • 94.02 (n)
  • 98.29 (a)
SFN 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sfn 35
  • 90.32 (n)
  • 97.58 (a)
Sfn 16
Sfn 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SFN 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SFN 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sfn 35
  • 90.59 (n)
  • 97.58 (a)
chicken
(Gallus gallus)
Aves SFN 35
  • 81.44 (n)
  • 80.08 (a)
SFN 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SFN 36
  • 79 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ywhabl 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta 14-3-3zeta 36
  • 64 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ftt-2 36
  • 63 (a)
ManyToMany
par-5 36
  • 63 (a)
ManyToMany
Species with no ortholog for SFN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SFN Gene

ENSEMBL:
Gene Tree for SFN (if available)
TreeFam:
Gene Tree for SFN (if available)

Paralogs for SFN Gene

Paralogs for SFN Gene

Selected SIMAP similar genes for SFN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SFN: view

Variants for SFN Gene

Sequence variations from dbSNP and Humsavar for SFN Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1060331 -- 26,864,391(+) CGAGA(C/T)TGAGG utr-variant-3-prime
rs1883660 -- 26,864,920(-) CTTTT(A/T)TGGCG downstream-variant-500B
rs3065004 -- 26,864,330(-) cacac(-/AC)cCATC utr-variant-3-prime
rs3208129 -- 26,864,362(+) GTGTG(C/T)GTGCG utr-variant-3-prime
rs11542704 -- 26,863,833(+) CACAC(C/T)CTCAG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for SFN Gene

Variant ID Type Subtype PubMed ID
nsv834524 CNV Gain+Loss 17160897
nsv7535 CNV Insertion 18451855

Relevant External Links for SFN Gene

HapMap Linkage Disequilibrium report
SFN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFN Gene

Disorders for SFN Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for SFN Gene including...

Search for SFN Gene in MalaCards »

(1) University of Copenhagen DISEASES for SFN Gene

(8) Novoseek inferred disease relationships for SFN Gene

Disease -log(P) Hits PubMed IDs
carcinoma squamous cell 51.4 3
adenocarcinoma 45.2 4
tumors 29.2 13
cancer 24.8 8
metaplasia 17.9 2

Relevant External Links for SFN

Genetic Association Database (GAD)
SFN
Human Genome Epidemiology (HuGE) Navigator
SFN
genes like me logo Genes that share disorders with SFN: view

No data available for UniProtKB/Swiss-Prot for SFN Gene

Publications for SFN Gene

  1. Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway. (PMID: 8515476) Leffers H. … Celis J.E. (J. Mol. Biol. 1993) 2 3 4 23
  2. The tumor suppressor gene 14-3-3 sigma is commonly methylated in normal and malignant lymphoid cells. (PMID: 12582028) Bhatia K. … GutiAcrrez M.I. (Cancer Epidemiol. Biomarkers Prev. 2003) 3 23
  3. Loss of 14-3-3sigma in prostate cancer and its precursors. (PMID: 15131044) Cheng L. … Eble J.N. (Clin. Cancer Res. 2004) 3 23
  4. Keratinocyte-releasable stratifin functions as a potent collagenase-stimulating factor in fibroblasts. (PMID: 15140222) Ghahary A. … Weinfeld M. (J. Invest. Dermatol. 2004) 3 23
  5. RACK1 and stratifin target DeltaNp63alpha for a proteasome degradation in head and neck squamous cell carcinoma cells upon DNA damage. (PMID: 15467455) Fomenkov A. … Ratovitski E.A. (Cell Cycle 2004) 3 23

Products for SFN Gene

  • Addgene plasmids for SFN

Sources for SFN Gene

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