Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SFN Gene

Aliases for SFN Gene

  • Stratifin 2 3 4 5
  • Epithelial Cell Marker Protein 1 3 4
  • 14-3-3 Sigma 2 3
  • 14-3-3 Protein Sigma 3
  • YWHAS 3
  • HME1 4

External Ids for SFN Gene

Previous GeneCards Identifiers for SFN Gene

  • GC01M028401
  • GC01P026221
  • GC01P026422
  • GC01P026795
  • GC01P026796
  • GC01P027062
  • GC01P027189
  • GC01P025443

Summaries for SFN Gene

GeneCards Summary for SFN Gene

SFN (Stratifin) is a Protein Coding gene. Diseases associated with SFN include Limbal Stem Cell Deficiency and Breast Cancer. Among its related pathways are LKB1 signaling events and Vesicle-mediated transport. GO annotations related to this gene include protein kinase binding and phosphoprotein binding. An important paralog of this gene is YWHAZ.

UniProtKB/Swiss-Prot for SFN Gene

  • Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.

  • p53-regulated inhibitor of G2/M progression.

Gene Wiki entry for SFN Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFN Gene

Genomics for SFN Gene

Regulatory Elements for SFN Gene

Enhancers for SFN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F026887 0.2 ENCODE 12.2 +24.1 24147 0.2 CTCF SMC3 RAD21 SFN HMGN2 GPN2 ENSG00000226698
GH01F026888 0.4 ENCODE 12.1 +26.6 26638 3.2 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 KLF13 PAF1 PIGV SFN ZDHHC18 HMGN2 GPN2 ENSG00000226698
GH01F026830 0.9 FANTOM5 ENCODE 12 -30.2 -30174 4.5 HDGF PKNOX1 ARNT MLX WRNIP1 SIN3A ARID4B DMAP1 ZNF143 SP5 ZDHHC18 PIGV SFN ENSG00000226698 GPATCH3 NUDC RPS6KA1 WDTC1 LOC101928728 OSTCP2
GH01F026824 1.1 FANTOM5 ENCODE 11.9 -35.8 -35785 6.5 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZDHHC18 ACTG1P20 HMGN2 NUDC ENSG00000231344 LOC105376890 ENSG00000207302 RPL39P7 LIN28A SFN
GH01F026798 1.2 Ensembl ENCODE 11.7 -62.8 -62814 3.0 FEZF1 RAD21 ZEB1 YY1 ZNF121 GLIS2 ZNF366 FOS ZMIZ1 CREM SFN ENSG00000226698 GPATCH3 NUDC MIR1976 RPS6KA1 HMGN2 GC01P026805 GC01P026802 PIR59173
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SFN on UCSC Golden Path with GeneCards custom track

Promoters for SFN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001518587 1562 3001 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143

Genomic Location for SFN Gene

Chromosome:
1
Start:
26,863,138 bp from pter
End:
26,864,457 bp from pter
Size:
1,320 bases
Orientation:
Plus strand

Genomic View for SFN Gene

Genes around SFN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFN Gene

Proteins for SFN Gene

  • Protein details for SFN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31947-1433S_HUMAN
    Recommended name:
    14-3-3 protein sigma
    Protein Accession:
    P31947
    Secondary Accessions:
    • Q6FH30
    • Q6FH51
    • Q96DH0

    Protein attributes for SFN Gene

    Size:
    248 amino acids
    Molecular mass:
    27774 Da
    Quaternary structure:
    • Homodimer. Interacts with KRT17 and SAMSN1 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29 and VPS35. Interacts with GAB2. Interacts with SRPK2. Interacts with COPS6. Interacts with RFWD2; this interaction leads to proteasomal degradation. Interacts with the Thr-369 phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB (PubMed:23572552).

    Three dimensional structures from OCA and Proteopedia for SFN Gene

    Alternative splice isoforms for SFN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SFN Gene

Post-translational modifications for SFN Gene

  • Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation.
  • Ubiquitination at Lys 49
  • Modification sites at PhosphoSitePlus

Other Protein References for SFN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SFN Gene

Domains & Families for SFN Gene

Protein Domains for SFN Gene

Suggested Antigen Peptide Sequences for SFN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P31947

UniProtKB/Swiss-Prot:

1433S_HUMAN :
  • Belongs to the 14-3-3 family.
Family:
  • Belongs to the 14-3-3 family.
genes like me logo Genes that share domains with SFN: view

Function for SFN Gene

Molecular function for SFN Gene

UniProtKB/Swiss-Prot Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
UniProtKB/Swiss-Prot Function:
p53-regulated inhibitor of G2/M progression.

Gene Ontology (GO) - Molecular Function for SFN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11574543
GO:0008426 protein kinase C inhibitor activity TAS 8515476
GO:0019901 protein kinase binding IEA --
GO:0019904 protein domain specific binding IEA --
GO:0042802 identical protein binding IPI 15778465
genes like me logo Genes that share ontologies with SFN: view
genes like me logo Genes that share phenotypes with SFN: view

Animal Models for SFN Gene

MGI Knock Outs for SFN:

Animal Model Products

miRNA for SFN Gene

miRTarBase miRNAs that target SFN

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SFN

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SFN Gene

Localization for SFN Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFN Gene

Cytoplasm. Nucleus. Secreted. Note=May be secreted by a non-classical secretory pathway.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SFN Gene COMPARTMENTS Subcellular localization image for SFN gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 5
nucleus 5
cytoskeleton 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SFN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS 8515476
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with SFN: view

Pathways & Interactions for SFN Gene

genes like me logo Genes that share pathways with SFN: view

SIGNOR curated interactions for SFN Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for SFN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0001836 release of cytochrome c from mitochondria IDA 11574543
GO:0003334 keratinocyte development IEA --
GO:0006469 negative regulation of protein kinase activity TAS 8515476
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
genes like me logo Genes that share ontologies with SFN: view

Drugs & Compounds for SFN Gene

(5) Drugs for SFN Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Excitatory Amino Acid Antagonists Pharma 1282
Excitatory Amino Acids Pharma 1297
Neurotransmitter Agents Pharma 17734
Glutamic Acid Nutra 214

(2) Additional Compounds for SFN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SFN: view

Transcripts for SFN Gene

mRNA/cDNA for SFN Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(348) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SFN Gene

Stratifin:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SFN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SFN Gene

No ASD Table

Relevant External Links for SFN Gene

GeneLoc Exon Structure for
SFN
ECgene alternative splicing isoforms for
SFN

Expression for SFN Gene

mRNA expression in normal human tissues for SFN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SFN Gene

This gene is overexpressed in Esophagus - Mucosa (x17.9), Skin - Not Sun Exposed (Suprapubic) (x10.4), Skin - Sun Exposed (Lower leg) (x7.8), Minor Salivary Gland (x5.6), and Vagina (x4.3).

Protein differential expression in normal tissues from HIPED for SFN Gene

This gene is overexpressed in Hair follicle (13.2) and Oral epithelium (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SFN Gene



NURSA nuclear receptor signaling pathways regulating expression of SFN Gene:

SFN

SOURCE GeneReport for Unigene cluster for SFN Gene:

Hs.523718

mRNA Expression by UniProt/SwissProt for SFN Gene:

P31947-1433S_HUMAN
Tissue specificity: Present mainly in tissues enriched in stratified squamous keratinizing epithelium.
genes like me logo Genes that share expression patterns with SFN: view

Primer Products

No data available for Protein tissue co-expression partners for SFN Gene

Orthologs for SFN Gene

This gene was present in the common ancestor of animals.

Orthologs for SFN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SFN 34 35
  • 99.73 (n)
dog
(Canis familiaris)
Mammalia SFN 34 35
  • 94.02 (n)
cow
(Bos Taurus)
Mammalia SFN 34 35
  • 92.17 (n)
rat
(Rattus norvegicus)
Mammalia Sfn 34
  • 90.59 (n)
mouse
(Mus musculus)
Mammalia Sfn 34 16 35
  • 90.32 (n)
oppossum
(Monodelphis domestica)
Mammalia SFN 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SFN 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves SFN 34 35
  • 81.44 (n)
lizard
(Anolis carolinensis)
Reptilia SFN 35
  • 79 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ywhabl 35
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta 14-3-3zeta 35
  • 64 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ftt-2 35
  • 63 (a)
ManyToMany
par-5 35
  • 63 (a)
ManyToMany
Species where no ortholog for SFN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SFN Gene

ENSEMBL:
Gene Tree for SFN (if available)
TreeFam:
Gene Tree for SFN (if available)

Paralogs for SFN Gene

Paralogs for SFN Gene

(8) SIMAP similar genes for SFN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SFN: view

Variants for SFN Gene

Sequence variations from dbSNP and Humsavar for SFN Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1060331 -- 26,864,391(+) CGAGA(C/T)TGAGG utr-variant-3-prime
rs112547702 -- 26,864,364(+) GTGTG(C/T)GCGCG utr-variant-3-prime
rs113302181 -- 26,863,975(+) CCACC(A/G)CCCCG utr-variant-3-prime
rs11542704 -- 26,863,833(+) CACAC(C/T)CTCAG reference, synonymous-codon
rs11542705 -- 26,863,677(+) GCCAT(A/G)GACAT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SFN Gene

Variant ID Type Subtype PubMed ID
nsv1000012 CNV gain 25217958
nsv7535 CNV insertion 18451855
nsv834524 CNV gain+loss 17160897

Variation tolerance for SFN Gene

Residual Variation Intolerance Score: 56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SFN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SFN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFN Gene

Disorders for SFN Gene

MalaCards: The human disease database

(4) MalaCards diseases for SFN Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
limbal stem cell deficiency
breast cancer
  • breast cancer, invasive ductal
popliteal pterygium syndrome 1
  • popliteal pterygium syndrome
colloid carcinoma of the pancreas
- elite association - COSMIC cancer census association via MalaCards
Search SFN in MalaCards View complete list of genes associated with diseases

Relevant External Links for SFN

Genetic Association Database (GAD)
SFN
Human Genome Epidemiology (HuGE) Navigator
SFN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SFN
genes like me logo Genes that share disorders with SFN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SFN Gene

Publications for SFN Gene

  1. Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway. (PMID: 8515476) Leffers H. … Celis J.E. (J. Mol. Biol. 1993) 2 3 4 22 64
  2. ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. (PMID: 23572552) Greninger A.L. … DeRisi J.L. (MBio 2013) 3 4 64
  3. Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI. (PMID: 22634725) Rose R. … Ottmann C. (J. Struct. Biol. 2012) 3 4 64
  4. COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3sigma. (PMID: 21625211) Choi H.H. … Lee M.H. (Oncogene 2011) 3 4 64
  5. Clinical significance of Stratifin, ERalpha and PR promoter methylation in tumor and serum DNA in Indian breast cancer patients. (PMID: 19961842) Mirza S. … Ralhan R. (Clin. Biochem. 2010) 3 22 64

Products for SFN Gene

Sources for SFN Gene

Content
Loading form....