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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SFN Gene

protein-coding   GIFtS: 66
GCID: GC01P027189

stratifin

 Explore 48 diseases affiliated with
SFN via our new
 Human Malady Compendium 
Biological research products
for SFN
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Stratifin3     14-3-3 Protein Sigma2
Stratifin3     14-3-3 Sigma2
YWHAS1 2     HME13
Epithelial Cell Marker Protein 12 3     

External Ids:    HGNC: 107731   Entrez Gene: 28102   Ensembl: ENSG000001757937   OMIM: 6012905   UniProtKB: P319473   

Export aliases for SFN gene to outside databases

Previous GC identifers: GC01M028401 GC01P026221 GC01P026422 GC01P026795 GC01P026796 GC01P026873 GC01P027062 GC01P025443


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: 1433S_HUMAN, P31947
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling
pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.
Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates
protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity)
Function: p53-regulated inhibitor of G2/M progression

Gene Wiki entry for SFN (Stratifin)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SFN gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSFN promoter sequence
   Search SABiosciences Chromatin IP Primers for SFN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SFN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.11

SFN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SFN gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P027189:  view genomic region     (about GC identifiers)

Start:
27,189,633 bp from pter      End:
27,190,947 bp from pter
Size:
1,315 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: 1433S_HUMAN, P31947 (See protein sequence)
Recommended Name: 14-3-3 protein sigma  
Size: 248 amino acids; 27774 Da
Subunit: Homodimer. Interacts with KRT17 and SAMSN1 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1,
VPS26A, VPS29, VPS35 and SFN. Interacts with GAB2. Interacts with SRPK2. Interacts with COPS6. Interacts with RFWD2;
this interaction leads to proteasomal degradation
Subcellular location: Cytoplasm. Nucleus (By similarity). Secreted. Note=May be secreted by a non-classical secretory
pathway
6/26 PDB 3D structures from and Proteopedia for SFN (see all 26):
1YWT (3D)        1YZ5 (3D)        3IQJ (3D)        3IQU (3D)        3IQV (3D)        3LW1 (3D)    
Secondary accessions: Q6FH30 Q6FH51 Q96DH0
Alternative splicing: 2 isoforms:  P31947-1   P31947-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SFN: NX_P31947

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P31947

  • SFN Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006133.1  
    ENSEMBL proteins: 
     ENSP00000340989  
    Reactome Protein details: P31947
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for SFN
    OriGene Purified Protein: SFN
    OriGene Protein Over-expression Lysate: SFN
    OriGene Custom Protein Services for SFN 
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    Novus Biologicals SFN Proteins
    Novus Biologicals SFN Lysates
    Sino Biological Recombinant Protein for SFN
    ProSpec Recombinant Protein for SFN
    Uscn Proteins for SFN

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS8515476
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--


    SFN for ontologies           About GeneDecksing



    SFN Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of SFN
    R&D Systems Antibodies for SFN (14-3-3 sigma)
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    Novus Biologicals SFN Antibodies
    Abcam antibodies for SFN 
    Uscn Antibodies for SFN
    ThermoFisher Antibody for SFN

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    Browse R&D Systems for biochemical assays
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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SFN


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SFN for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR023410 14-3-3_domain
     IPR000308 14-3-3
     IPR023409 14-3-3_CS

    Graphical View of Domain Structure for InterPro Entry P31947

    ProtoNet protein and cluster: P31947

    1 Blocks protein family: IPB000308 14-3-3 protein

    UniProtKB/Swiss-Prot: 1433S_HUMAN, P31947
    Similarity: Belongs to the 14-3-3 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: 1433S_HUMAN, P31947
    Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling
    pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.
    Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates
    protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity)
    Function: p53-regulated inhibitor of G2/M progression

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SFN
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate SFN (see all 14):
    hsa-miR-3166 hsa-miR-513a-5p hsa-miR-2278 hsa-miR-1260b hsa-miR-597 hsa-miR-3157-5p hsa-miR-1260 hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidSFN 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SFN (see all 4)
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    OriGene siRNA: SFN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SFN

    Gene Editing
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    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SFN (NM_006142)
    Sino Biological Human cDNA Clone for SFN
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFN 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFN

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008426protein kinase C inhibitor activity TAS8515476
    GO:0019901protein kinase binding IEA--
    GO:0019904protein domain specific binding IEA--
    GO:0051219phosphoprotein binding IEA--


    SFN for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for SFN:
     Increased cell death in breast  Increased circadian rhythm amp 

    Animal Models:
         Mouse knock-out Sfntm1Mak for SFN
         15/18 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Sfn) (see all 18):
     cellular  craniofacial  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size  hearing/vestibular/ear  hematopoietic system  immune system  integument 
     limbs/digits/tail  liver/biliary system  mortality/aging  reproductive system  respiratory system 

    SFN for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/28 super-pathways (see all 28About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
    Activation of BH3-only proteins0.30
    Activation of BAD and translocation to mitochondria 0.15
    Intrinsic Pathway for Apoptosis0.23
    2Cell cycle_Role of 14-3-3 proteins in cell cycle regulation
    Cell cycle_Role of 14-3-3 proteins in cell cycle regulation1.00
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation1.00
    3Immune response_Function of MEF2 in T lymphocytes
    Immune response_Function of MEF2 in T lymphocytes1.00
    Immune response Function of MEF2 in T lymphocytes0.90
    4Membrane Trafficking
    Membrane Trafficking1.00
    Translocation of GLUT4 to the Plasma Membrane0.32
    5Apoptosis and survival BAD phosphorylation
    Apoptosis and survival BAD phosphorylation1.00
    Apoptosis and survival_BAD phosphorylation0.99

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    4 EMD Millipore Pathways for SFN
        Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Apoptosis and survival BAD phosphorylation

    1 R&D Systems Pathway for SFN
        Apoptosis Signaling Pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SFN
        p53 Signaling
    DNA Damage Induced 14-3-3Sigma Signaling

    4 GeneGo (Thomson Reuters) Pathways for SFN
        Apoptosis and survival BAD phosphorylation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation

    5/17 BioSystems Pathways for SFN (see all 17
        Myometrial Relaxation and Contraction Pathways
    DNA damage response
    Calcium Regulation in the Cardiac Cell
    Alpha6-Beta4 Integrin Signaling Pathway
    p38 signaling mediated by MAPKAP kinases

    5/6        Reactome Pathways for SFN (see all 6)
        Activation of BH3-only proteins
    Activation of BAD and translocation to mitochondria
    Intrinsic Pathway for Apoptosis
    Membrane Trafficking
    Translocation of GLUT4 to the Plasma Membrane


    3         Kegg Pathways  (Kegg details for SFN):
        Cell cycle
    p53 signaling pathway
    Aldosterone-regulated sodium reabsorption


    SFN for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SFN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/242 Interacting proteins for SFN (P319471, 2, 3 ENSP000003409894) via UniProtKB, MINT, STRING, and/or I2D (see all 242)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLK4O004441, 2, 3, ENSP000002708614EBI-476295,EBI-746202 MINT-66797 I2D: score=6 STRING: ENSP00000270861
    HNRNPDQ141032, 3, ENSP000003131994MINT-2881488 MINT-2879878 MINT-2881547 MINT-2881524 MINT-2881604 I2D: score=2 STRING: ENSP00000313199
    BADQ929342, 3, ENSP000003091034MINT-8009673 MINT-66103 MINT-8009831 I2D: score=5 STRING: ENSP00000309103
    HDAC4P565242, 3, ENSP000002646064MINT-3975818 MINT-8007544 MINT-8007551 I2D: score=2 STRING: ENSP00000264606
    GPRIN2O602692, 3, ENSP000003634334MINT-3976495 MINT-68344 I2D: score=5 STRING: ENSP00000363433
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein kinase activity IEA--
    GO:0001836release of cytochrome c from mitochondria IDA11574543
    GO:0006469negative regulation of protein kinase activity TAS8515476
    GO:0006915apoptotic process IDA11574543
    GO:0007165signal transduction TAS8515476


    SFN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SFN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SFN
    3 Novoseek chemical compound relationships for SFN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty acid 4.93 2 10546833 (1), 8824785 (1)
    calcium 0 2 15305371 (1), 16815451 (1)
    superoxide 0 1 16889763 (1)

    Search CenterWatch for drugs/clinical trials and news about SFN / 1433S 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SFN gene: 
    NM_006142.3  

    Unigene Cluster for SFN:

    Stratifin
    Hs.523718  [show with all ESTs]
    Unigene Representative Sequence: BC023552
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000339276(uc001bnc.1)

    miRNA
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate SFN (see all 14):
    hsa-miR-3166 hsa-miR-513a-5p hsa-miR-2278 hsa-miR-1260b hsa-miR-597 hsa-miR-3157-5p hsa-miR-1260 hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidSFN 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SFN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SFN

    Additional cDNA sequence: 

    AF029082.1 BC000329.2 BC000995.2 BC001550.1 BC002995.1 BC023552.2 CR541905.1 CR541926.1 
    M93010.1 

    8 DOTS entries:

    DT.95272099  DT.100776536  DT.113912  DT.100767051  DT.100776537  DT.121340812  DT.97855083  DT.91782977 

    24/348 AceView cDNA sequences (see all 348):

    BM824967 BM551781 BM761220 BM126957 BM557712 BQ887249 BQ222164 BM761381 
    AW117738 BU542087 BQ887556 BM550264 BE910042 BM909138 BM550154 BU542261 
    CR541926 BM817517 BQ958425 BM811495 BM563640 BM560634 BG681908 BM844023 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SFN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTCCTCTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See SFN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SFN

    SOURCE GeneReport for Unigene cluster: Hs.523718

    UniProtKB/Swiss-Prot: 1433S_HUMAN, P31947
    Tissue specificity: Present mainly in tissues enriched in stratified squamous keratinizing epithelium

        SABiosciences Expression via Pathway-Focused PCR Arrays including SFN (see all 8): 
              Nitric Oxide Signaling Pathway in human mouse rat
              Prostate Cancer in human mouse rat
              Cell Cycle in human mouse rat
              Breast Cancer in human mouse rat
              Mitochondria in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SFN gene from 6/27 species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SFN1 stratifin 80.76(n)
    79.27(a)
      408037  XM_003642560.1  XP_003642608.1 
    lizard
    (Anolis carolinensis)
    Reptilia SFN6
    --
    79(a)
    1 ↔ 1
    GL343488.1(150471-151211)
    fruit fly
    (Drosophila melanogaster)
    Insecta 14-3-3zeta6
    14-3-3zeta
    63(a)
    possible ortholog
    2R(5987182-5997192)
    worm
    (Caenorhabditis elegans)
    Secernentea par-56
    ftt-26
    (see all 3)
    14-3-3-like protein 2
    (see all 3)
    64(a)
    63(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    IV(11820482-11821901)
    X(11603640-11605354)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GRF36
    GRF26
    (see all 14)
    14-3-3-like protein GF14 omega
    (see all 14)
    55(a)
    55(a)
    (see all 14)
    many ↔ many
    many ↔ many
    (see all 14)
    5(15409697-15411516)
    1(29461671-29463385)
    rice
    (Oryza sativa)
    Liliopsida AY224434.12   -- 77.33(n)    AY224434.1 


    ENSEMBL Gene Tree for SFN (if available)
    TreeFam Gene Tree for SFN (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SFN gene
    YWHAH2  YWHAE2  YWHAQ2  YWHAB2  YWHAG2  YWHAZ2  
    8 SIMAP similar genes for SFN using alignment to 1 protein entry:     1433S_HUMAN:
    YWHAB    YWHAQ    YWHAZ    YWHAG    YWHAH    YWHAE/FAM22A fusion
    YWHAE/FAM22B fusion    YWHAE

    SFN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/57 NCBI SNPs in SFN are shown (see all 57    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1850623151,2
    --27187701(+) AGATAC/TCCTCT 1 -- us2k10--------
    rs802424541,2
    F,--27187780(+) GGGACG/ATCAAA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1902176661,2
    --27187815(+) GAAACC/TCTGTA 1 -- us2k10--------
    rs1809005661,2
    --27187872(+) GATCTC/TGTCTT 1 -- us2k10--------
    rs1842073861,2
    --27187873(+) ATCTCA/GTCTTT 1 -- us2k10--------
    rs343600191,2
    C,--27187876(+) GTCTT-/TGGTCC 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs345436481,2
    C,F,H--27187881(+) TTTGGT/GCCCCA 1 -- us2k111Minor allele frequency- G:0.04NS EA 1780
    rs2003923211,2
    --27187881(+) TTTGG-/TCCCCA 1 -- us2k10--------
    rs1899142421,2
    --27188032(+) GAGCCC/TCATCT 1 -- us2k10--------
    rs348899711,2
    C,F,H,--27188057(+) GGTGGG/AGCAGA 1 -- us2k115Minor allele frequency- A:0.04NS EA NA CSA WA 2044

    HapMap Linkage Disequilibrium report for SFN (27189633 - 27190947 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SFN
         1 CNV: 4218

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SFN for disorders           About GeneDecksing

    OMIM gene information: 601290    OMIM disorders: --

    20/48 diseases for SFN (see all 48):    About MalaCards
    squamous cell carcinoma    phlebotomus fever    laryngeal squamous cell carcinoma    bladder squamous cell carcinoma
    adenoid cystic carcinoma    oral squamous cell carcinoma    esophageal squamous cell carcinoma    pancreatic ductal adenocarcinoma
    transitional cell carcinoma    chronic lymphocytic leukemia    intrahepatic cholangiocarcinoma    epithelial ovarian cancer
    lymphocytic leukemia    adenoiditis    carcinoma    laryngitis
    papillary carcinoma    ovarian cancer    bladder carcinoma    cholangiocarcinoma

    1 disease from the University of Copenhagen DISEASES database for SFN:
    Carcinoma

    8 Novoseek disease relationships for SFN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 51.4 4 15986332 (1), 18407684 (1), 18702824 (1)
    adenocarcinoma 45.2 6 15908786 (1), 10546833 (1), 19596931 (1), 18702824 (1)
    tumors 29.2 25 19961842 (5), 10233778 (1), 14736829 (1), 19260470 (1) (see all 9)
    cancer 24.8 8 16492916 (2), 18339795 (2), 10969206 (1), 15986332 (1) (see all 6)
    metaplasia 17.9 2 16492916 (2)
    shock 8.86 2 16889763 (1), 18452139 (1)
    breast cancer 5.08 4 19961842 (3), 11423985 (1)
    carcinoma 0 3 15044106 (1), 18036402 (1)

    Genetic Association Database (GAD): SFN
    Human Genome Epidemiology (HuGE) Navigator: SFN (5 documents)

    Export disorders for SFN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SFN gene, integrated from 9 sources (see all 203):
    (articles sorted by number of sources associating them with SFN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway. (PubMed id 8515476)1, 2, 3, 9 Leffers H.... Celis J.E. (1993)
    2. COP9 signalosome subunit 6 stabilizes COP1, which fun ctions as an E3 ubiquitin ligase for 14-3-3I8. (PubMed id 21625211)1, 2 Choi H.H....Lee M.H. (2011)
    3. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738)1, 2 Brummer T.... Daly R.J. (2008)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    6. A structural basis for 14-3-3sigma functional specificity. (PubMed id 15731107)1, 2 Wilker E.W.... Yaffe M.B. (2005)
    7. Exportin 7 defines a novel general nuclear export pathway. (PubMed id 15282546)1, 2 Mingot J.-M.... Goerlich D. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. (PubMed id 9659898)1, 2 Hermeking H.... Vogelstein B. (1997)
    10. Complementary DNA cloning of a novel epithelial cell marker protein, HME1, that may be down-regulated in neoplastic mammary cells. (PubMed id 1390337)1, 2 Prasad G.L.... Cooper H.L. (1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2810 HGNC: 10773 AceView: SFN Ensembl:ENSG00000175793 euGenes: HUgn2810
    ECgene: SFN Kegg: 2810 H-InvDB: SFN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SFN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SFN Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SFN gene:
    Search GeneIP for patents involving SFN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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