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SFN Gene

protein-coding   GIFtS: 68
GCID: GC01P027189

Stratifin

  See SFN-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
stratifin1 2     14-3-3 Protein Sigma2
Stratifin3     YWHAS2
14-3-3 Sigma1 2     HME13
Epithelial Cell Marker Protein 12 3     

External Ids:    HGNC: 107731   Entrez Gene: 28102   Ensembl: ENSG000001757937   OMIM: 6012905   UniProtKB: P319473   

Export aliases for SFN gene to outside databases

Previous GC identifers: GC01M028401 GC01P026221 GC01P026422 GC01P026795 GC01P026796 GC01P026873 GC01P027062 GC01P025443


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SFN Gene:
SFN (stratifin) is a protein-coding gene. Diseases associated with SFN include limbal stem cell deficiency, and bladder squamous cell carcinoma. GO annotations related to this gene include protein kinase binding and phosphoprotein binding. An important paralog of this gene is YWHAH.

UniProtKB/Swiss-Prot: 1433S_HUMAN, P31947
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized
signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or
phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When
bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also
regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53
Function: p53-regulated inhibitor of G2/M progression

Gene Wiki entry for SFN (Stratifin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the SFN gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSFN promoter sequence
   Search Chromatin IP Primers for SFN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SFN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.11

SFN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SFN gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P027189:  view genomic region     (about GC identifiers)

Start:
27,189,633 bp from pter      End:
27,190,947 bp from pter
Size:
1,315 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: 1433S_HUMAN, P31947 (See protein sequence)
Recommended Name: 14-3-3 protein sigma  
Size: 248 amino acids; 27774 Da
Subunit: Homodimer. Interacts with KRT17 and SAMSN1 (By similarity). Found in a complex with XPO7, EIF4A1,
ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with GAB2. Interacts with SRPK2. Interacts with COPS6. Interacts
with RFWD2; this interaction leads to proteasomal degradation
Selected PDB 3D structures from and Proteopedia for SFN (see all 42):
1YWT (3D)        1YZ5 (3D)        3IQJ (3D)        3IQU (3D)        3IQV (3D)        3LW1 (3D)    
Secondary accessions: Q6FH30 Q6FH51 Q96DH0
Alternative splicing: 2 isoforms:  P31947-1   P31947-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SFN: NX_P31947

Explore proteomics data for SFN at MOPED

Post-translational modifications: 

  • Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation1
  • Ubiquitination2 at Lys11, Lys49, Lys122, Lys124
  • Modification sites at PhosphoSitePlus

  • See SFN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006133.1  
    ENSEMBL proteins: 
     ENSP00000340989  
    Reactome Protein details: P31947

    SFN Human Recombinant Protein Products:

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    Novus Biologicals SFN Proteins
    Novus Biologicals SFN Lysates
    Sino Biological Recombinant Protein for SFN
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    Cloud-Clone Corp. Proteins for SFN

     
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    SFN Antibody Products:

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    SFN Assay Products:

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    Search eBioscience for ELISAs for SFN 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR023409 14-3-3_CS
     IPR023410 14-3-3_domain
     IPR000308 14-3-3

    Graphical View of Domain Structure for InterPro Entry P31947

    ProtoNet protein and cluster: P31947

    1 Blocks protein domain: IPB000308 14-3-3 protein

    UniProtKB/Swiss-Prot: 1433S_HUMAN, P31947
    Similarity: Belongs to the 14-3-3 family


    Find genes that share domains with SFN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 1433S_HUMAN, P31947
    Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized
    signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or
    phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When
    bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also
    regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53
    Function: p53-regulated inhibitor of G2/M progression

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11574543
    GO:0008426protein kinase C inhibitor activity TAS8515476
    GO:0019901protein kinase binding IEA--
    GO:0019904protein domain specific binding IEA--
    GO:0051219phosphoprotein binding IEA--
         
    Find genes that share ontologies with SFN           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SFN:
     Increased cell death in breast  Increased circadian rhythm amp 

         Selected MGI mutant phenotypes (inferred from 3 alleles(MGI details for Sfn) (see all 18):
     cellular  craniofacial  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size/body  hearing/vestibular/ear  hematopoietic system  immune system  integument 
     limbs/digits/tail  liver/biliary system  mortality/aging  reproductive system  respiratory system 

    Find genes that share phenotypes with SFN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sfntm1Mak for SFN

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SFN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SFN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SFN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SFN

    miRNA
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    miRTarBase miRNAs that target SFN:
    hsa-mir-34a-5p (MIRT025569), hsa-mir-1 (MIRT024082)

    Block miRNA regulation of human, mouse, rat SFN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SFN (see all 14):
    hsa-miR-3166 hsa-miR-513a-5p hsa-miR-2278 hsa-miR-1260b hsa-miR-597 hsa-miR-3157-5p hsa-miR-1260 hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidSFN 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SFN
    Predesigned siRNA for gene silencing in human, mouse, rat SFN

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SFN (NM_006142)
    Sino Biological Human cDNA Clone for SFN
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFN
    Addgene plasmids for SFN 

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    In Situ Assay
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    1433S_HUMAN, P31947: Cytoplasm. Nucleus (By similarity). Secreted. Note=May be secreted by a non-classical
    secretory pathway
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol4
    nucleus3
    plasma membrane3
    cytoskeleton2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS8515476
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0030659cytoplasmic vesicle membrane TAS--

    Find genes that share ontologies with SFN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SFN About   (see all 27)  
    See pathways by source

    SuperPathContained pathways About
    1p53 signaling pathway
    DNA damage response0.41
    p53 signaling pathway0.41
    2Activation of BH3-only proteins
    Activation of BH3-only proteins0.68
    Activation of BAD and translocation to mitochondria0.00
    Intrinsic Pathway for Apoptosis0.68
    3Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43
    Calcium Regulation in the Cardiac Cell0.43
    4Immune response Function of MEF2 in T lymphocytes
    Development Role of HDAC and calcium calmodulin dependent kinase CaMK in control of skeletal myogenesis0.38
    Immune response Function of MEF2 in T lymphocytes0.38
    5Clathrin derived vesicle budding
    Membrane Trafficking0.32
    Translocation of GLUT4 to the Plasma Membrane0.32


    Find genes that share SuperPaths with SFN           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for SFN
        Apoptosis Signaling Pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SFN
        p53 Signaling
    DNA Damage Induced 14-3-3Sigma Signaling

    4 GeneGo (Thomson Reuters) Pathways for SFN
        Apoptosis and survival BAD phosphorylation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation

    Selected BioSystems Pathways for SFN (see all 17)
        Myometrial Relaxation and Contraction Pathways
    DNA damage response
    Calcium Regulation in the Cardiac Cell
    Alpha6-Beta4 Integrin Signaling Pathway
    Direct p53 effectors


    2 Reactome Pathways for SFN
        Activation of BAD and translocation to mitochondria
    Translocation of GLUT4 to the plasma membrane


    3 Kegg Pathways  (Kegg details for SFN):
        Cell cycle
    p53 signaling pathway
    Aldosterone-regulated sodium reabsorption

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SFN (see all 8): 
              Nitric Oxide Signaling Pathway in human mouse rat
              Prostate Cancer in human mouse rat
              Cell Cycle in human mouse rat
              Breast Cancer in human mouse rat
              Mitochondria in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SFN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SFN (P319471, 2, 3 ENSP000003409894) via UniProtKB, MINT, STRING, and/or I2D (see all 312)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BADQ929341, 2, 3, ENSP000003091034EBI-476295,EBI-700771 MINT-8009673 MINT-66103 MINT-8009831 I2D: score=5 STRING: ENSP00000309103
    HDAC4P565241, 2, 3, ENSP000002646064EBI-476295,EBI-308629 MINT-3975818 MINT-8007544 MINT-8007551 I2D: score=2 STRING: ENSP00000264606
    GPRIN2O602691, 2, 3, ENSP000003634334EBI-476295,EBI-740397 MINT-3976495 MINT-68344 I2D: score=5 STRING: ENSP00000363433
    ERRFI1Q9UJM31, 2, 3EBI-476295,EBI-2941912 MINT-3975496 MINT-3976686 MINT-3976701 I2D: score=3 
    HDAC5Q9UQL61, 2, 3, ENSP000002259834EBI-476295,EBI-715576 MINT-8007109 MINT-8007102 I2D: score=3 STRING: ENSP00000225983
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    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0001836release of cytochrome c from mitochondria IDA11574543
    GO:0006469negative regulation of protein kinase activity TAS8515476
    GO:0006915apoptotic process TAS--
    GO:0007165signal transduction TAS8515476

    Find genes that share ontologies with SFN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SFN (1433S)

    3 Novoseek inferred chemical compound relationships for SFN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty acid 4.93 2 10546833 (1), 8824785 (1)
    calcium 0 2 15305371 (1), 16815451 (1)
    superoxide 0 1 16889763 (1)



    Find genes that share compounds with SFN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SFN gene: 
    NM_006142.3  

    Unigene Cluster for SFN:

    Stratifin
    Hs.523718  [show with all ESTs]
    Unigene Representative Sequence: BC023552
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000339276(uc001bnc.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SFN (see all 14):
    hsa-miR-3166 hsa-miR-513a-5p hsa-miR-2278 hsa-miR-1260b hsa-miR-597 hsa-miR-3157-5p hsa-miR-1260 hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidSFN 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat SFN
      QuantiFast Probe-based Assays in human, mouse, rat SFN

    Additional mRNA sequence: 

    AF029082.1 BC000329.2 BC000995.2 BC001550.1 BC002995.1 BC023552.2 CR541905.1 CR541926.1 
    M93010.1 

    8 DOTS entries:

    DT.95272099  DT.100776536  DT.113912  DT.100767051  DT.100776537  DT.121340812  DT.97855083  DT.91782977 

    Selected AceView cDNA sequences (see all 348):

    CA454157 T28709 NM_006142 BM908421 BM908333 BQ958425 BM824871 BE122860 
    BE711319 BG681894 BM761530 BF916659 BM910872 BI085298 BM844651 BM549700 
    BM560661 BM817517 BM560634 BM127570 BM911111 BM848111 BG681908 BF917675 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SFN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCCTCTCA
    SFN Expression
    About this image


    SFN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Renal Collecting Duct System
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Thymus (Hematopoietic System)
             Thymus
    SFN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SFN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523718

    UniProtKB/Swiss-Prot: 1433S_HUMAN, P31947
    Tissue specificity: Present mainly in tissues enriched in stratified squamous keratinizing epithelium

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SFN (see all 8): 
              Nitric Oxide Signaling Pathway in human mouse rat
              Prostate Cancer in human mouse rat
              Cell Cycle in human mouse rat
              Breast Cancer in human mouse rat
              Mitochondria in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat SFN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SFN gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sfn1 , 5 stratifin1, 5 90.32(n)1
    97.58(a)1
      4 (66.25 cM)5
    559481  NM_018754.21  NP_061224.21 
     1336005565 
    chicken
    (Gallus gallus)
    Aves SFN1 stratifin 81.44(n)
    80.08(a)
      408037  XM_003642560.2  XP_003642608.1 
    lizard
    (Anolis carolinensis)
    Reptilia SFN6
    stratifin
    79(a)
    1 ↔ 1
    GL343488.1(150471-151211)
    zebrafish
    (Danio rerio)
    Actinopterygii ywhabl6
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenas...
    66(a)
    1 ↔ 1
    16(26920470-26935184) ENSDARG00000040287
    fruit fly
    (Drosophila melanogaster)
    Insecta 14-3-3zeta6
    14-3-3zeta
    64(a)
    1 → many
    2R(5987182-5997192)
    worm
    (Caenorhabditis elegans)
    Secernentea par-56
    ftt-26
    Protein FTT-2, isoform a
    63(a)
    63(a)
    many ↔ many
    many ↔ many
    IV(11820505-11821917) WBGene00003920
    X(11603707-11605412) WBGene00001502
    rice
    (Oryza sativa)
    Liliopsida AY224434.12   -- 77.33(n)    AY224434.1 


    ENSEMBL Gene Tree for SFN (if available)
    TreeFam Gene Tree for SFN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SFN gene
    YWHAH2  YWHAE2  YWHAB2  YWHAQ2  YWHAG2  YWHAZ2  
    8 SIMAP similar genes for SFN using alignment to 1 protein entry:     1433S_HUMAN:
    YWHAB    YWHAQ    YWHAZ    YWHAG    YWHAH    YWHAE/FAM22A fusion
    YWHAE/FAM22B fusion    YWHAE

    Find genes that share paralogs with SFN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SFN (see all 81)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1850623151,2
    C--27187701(+) AGATAC/TCCTCT 1 -- us2k10--------
    rs802424541,2
    F--27187780(+) GGGACG/ATCAAA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1902176661,2
    --27187815(+) GAAACC/TCTGTA 1 -- us2k10--------
    rs1809005661,2
    C--27187872(+) GATCTC/TGTCTT 1 -- us2k10--------
    rs1842073861,2
    --27187873(+) ATCTCA/GTCTTT 1 -- us2k10--------
    rs343600191,2
    C--27187876(+) GTCTT-/TGGTCC 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs345436481,2
    C,F,H--27187881(+) TTTGGT/GCCCCA 1 -- us2k111Minor allele frequency- G:0.04NS EA 1780
    rs2003923211,2
    --27187881(+) TTTGG-/TCCCCA 1 -- us2k10--------
    rs1899142421,2
    C--27188032(+) GAGCCC/TCATCT 1 -- us2k10--------
    rs348899711,2
    C,F,H--27188057(+) GGTGGG/AGCAGA 1 -- us2k115Minor allele frequency- A:0.04NS EA NA CSA WA 2044

    HapMap Linkage Disequilibrium report for SFN (27189633 - 27190947 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SFN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7535CNV Insertion18451855
    nsv834524CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SFN
    DNA2.0 Custom Variant and Variant Library Synthesis for SFN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601290    OMIM disorders: --

    2 diseases for SFN:    
    About MalaCards
    limbal stem cell deficiency    bladder squamous cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for SFN:
    Carcinoma

    Find genes that share disorders with SFN           About GenesLikeMe

    8 Novoseek inferred disease relationships for SFN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 51.4 4 15986332 (1), 18407684 (1), 18702824 (1)
    adenocarcinoma 45.2 6 15908786 (1), 10546833 (1), 19596931 (1), 18702824 (1)
    tumors 29.2 25 19961842 (5), 10233778 (1), 14736829 (1), 19260470 (1) (see all 9)
    cancer 24.8 8 16492916 (2), 18339795 (2), 10969206 (1), 15986332 (1) (see all 6)
    metaplasia 17.9 2 16492916 (2)
    shock 8.86 2 16889763 (1), 18452139 (1)
    breast cancer 5.08 4 19961842 (3), 11423985 (1)
    carcinoma 0 3 15044106 (1), 18036402 (1)

    Genetic Association Database (GAD): SFN
    Human Genome Epidemiology (HuGE) Navigator: SFN (5 documents)

    Export disorders for SFN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SFN gene, integrated from 10 sources (see all 220):
    (articles sorted by number of sources associating them with SFN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway. (PubMed id 8515476)1, 2, 3, 9 Leffers H.... Celis J.E. (J. Mol. Biol. 1993)
    2. COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3sigma. (PubMed id 21625211)1, 2 Choi H.H.... Lee M.H. (Oncogene 2011)
    3. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738)1, 2 Brummer T.... Daly R.J. (EMBO J. 2008)
    4. CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2. (PubMed id 18382127)1, 2 Yang W....El-Deiry W.S. (Cell Cycle 2008)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    7. A structural basis for 14-3-3sigma functional specificity. (PubMed id 15731107)1, 2 Wilker E.W.... Yaffe M.B. (J. Biol. Chem. 2005)
    8. Exportin 7 defines a novel general nuclear export pathway. (PubMed id 15282546)1, 2 Mingot J.-M.... Goerlich D. (EMBO J. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. (PubMed id 9659898)1, 2 Hermeking H.... Vogelstein B. (Mol. Cell 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2810 HGNC: 10773 AceView: SFN Ensembl:ENSG00000175793 euGenes: HUgn2810
    ECgene: SFN Kegg: 2810 H-InvDB: SFN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SFN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SFN Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SFN gene:
    Search GeneIP for patents involving SFN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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