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Aliases for SFMBT2 Gene

Aliases for SFMBT2 Gene

  • Scm Like With Four Mbt Domains 2 2 3 5
  • Scm-Related Gene Containing Four Mbt Domains 2 2
  • Scm-Like With 4 MBT Domains Protein 2 4
  • KIAA1617 4

External Ids for SFMBT2 Gene

Previous GeneCards Identifiers for SFMBT2 Gene

  • GC10M007354
  • GC10M007208

Summaries for SFMBT2 Gene

GeneCards Summary for SFMBT2 Gene

SFMBT2 (Scm Like With Four Mbt Domains 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and histone binding. An important paralog of this gene is SFMBT1.

UniProtKB/Swiss-Prot for SFMBT2 Gene

  • Transcriptional repressor of HOXB13 gene.

Additional gene information for SFMBT2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFMBT2 Gene

Genomics for SFMBT2 Gene

GeneHancer (GH) Regulatory Elements for SFMBT2 Gene

Promoters and enhancers for SFMBT2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I007406 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 559.6 +2.3 2278 5 PKNOX1 SMAD1 SIN3A FEZF1 ZNF2 ZBTB7B YY1 ZNF302 ZNF143 ZNF207 SFMBT2 KIN TAF3 ENSG00000278982 GC10P007374
GH10I007412 Enhancer 0.6 ENCODE 550.8 -1.2 -1158 0.2 PKNOX1 USF1 MAX SIN3A USF2 ZNF507 ZBTB33 SETDB1 EZH2 ENSG00000278982 SFMBT2 GC10P007419
GH10I007413 Enhancer 0.5 ENCODE 550.8 -1.0 -980 0 PKNOX1 MAX SIN3A ZBTB33 SETDB1 ZNF507 EZH2 ENSG00000278982 SFMBT2 GC10P007419
GH10I007411 Enhancer 0.3 ENCODE 550.8 -0.5 -518 0.1 EZH2 ENSG00000278982 SFMBT2 GC10P007419
GH10I008049 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.9 -645.6 -645563 16 HDGF PKNOX1 FOXA2 MLX SIN3A FEZF1 ZNF2 ZNF213 E2F8 ZNF143 GATA3 KIN TAF3 SFMBT2 GATA3-AS1 ENSG00000232638 GC10P008092 GC10M008036 GC10M008037
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SFMBT2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SFMBT2 gene promoter:

Genomic Locations for SFMBT2 Gene

Genomic Locations for SFMBT2 Gene
chr10:7,158,624-7,411,486
(GRCh38/hg38)
Size:
252,863 bases
Orientation:
Minus strand
chr10:7,200,586-7,453,450
(GRCh37/hg19)

Genomic View for SFMBT2 Gene

Genes around SFMBT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFMBT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFMBT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFMBT2 Gene

Proteins for SFMBT2 Gene

  • Protein details for SFMBT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VUG0-SMBT2_HUMAN
    Recommended name:
    Scm-like with four MBT domains protein 2
    Protein Accession:
    Q5VUG0
    Secondary Accessions:
    • A7MD09
    • Q9HCF5

    Protein attributes for SFMBT2 Gene

    Size:
    894 amino acids
    Molecular mass:
    100563 Da
    Quaternary structure:
    • Interacts with YY1. Interacts with methylated histones H3K9me2 and H4K20me2, but not with H3K4me2, nor H3K9Ac.
    SequenceCaution:
    • Sequence=BAB13443.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SFMBT2 Gene

neXtProt entry for SFMBT2 Gene

Post-translational modifications for SFMBT2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SFMBT2 Gene

Domains & Families for SFMBT2 Gene

Gene Families for SFMBT2 Gene

Protein Domains for SFMBT2 Gene

Suggested Antigen Peptide Sequences for SFMBT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SFMBT2: view

No data available for UniProtKB/Swiss-Prot for SFMBT2 Gene

Function for SFMBT2 Gene

Molecular function for SFMBT2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor of HOXB13 gene.

Phenotypes From GWAS Catalog for SFMBT2 Gene

Gene Ontology (GO) - Molecular Function for SFMBT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23385818
GO:0042393 histone binding IDA 23385818
genes like me logo Genes that share ontologies with SFMBT2: view
genes like me logo Genes that share phenotypes with SFMBT2: view

miRNA for SFMBT2 Gene

miRTarBase miRNAs that target SFMBT2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SFMBT2 Gene

Localization for SFMBT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFMBT2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SFMBT2 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SFMBT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 23385818
GO:0016235 aggresome IDA --
GO:0016607 nuclear speck IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with SFMBT2: view

Pathways & Interactions for SFMBT2 Gene

SuperPathways for SFMBT2 Gene

No Data Available

Interacting Proteins for SFMBT2 Gene

Gene Ontology (GO) - Biological Process for SFMBT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0010629 negative regulation of gene expression IDA 23385818
genes like me logo Genes that share ontologies with SFMBT2: view

No data available for Pathways by source and SIGNOR curated interactions for SFMBT2 Gene

Drugs & Compounds for SFMBT2 Gene

No Compound Related Data Available

Transcripts for SFMBT2 Gene

Unigene Clusters for SFMBT2 Gene

Scm-like with four mbt domains 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SFMBT2 Gene

No ASD Table

Relevant External Links for SFMBT2 Gene

GeneLoc Exon Structure for
SFMBT2
ECgene alternative splicing isoforms for
SFMBT2

Expression for SFMBT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SFMBT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SFMBT2 Gene

This gene is overexpressed in Heart (57.0) and Synovial fluid (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SFMBT2 Gene



Protein tissue co-expression partners for SFMBT2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SFMBT2 Gene:

SFMBT2

SOURCE GeneReport for Unigene cluster for SFMBT2 Gene:

Hs.407983

Evidence on tissue expression from TISSUES for SFMBT2 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with SFMBT2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SFMBT2 Gene

Orthologs for SFMBT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SFMBT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SFMBT2 33 34
  • 98.25 (n)
dog
(Canis familiaris)
Mammalia SFMBT2 33 34
  • 88.14 (n)
oppossum
(Monodelphis domestica)
Mammalia SFMBT2 34
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SFMBT2 34
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SFMBT2 33 34
  • 85.75 (n)
rat
(Rattus norvegicus)
Mammalia Sfmbt2 33
  • 81.74 (n)
mouse
(Mus musculus)
Mammalia Sfmbt2 33 16 34
  • 79.46 (n)
chicken
(Gallus gallus)
Aves SFMBT2 33 34
  • 78.23 (n)
lizard
(Anolis carolinensis)
Reptilia SFMBT2 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sfmbt2 33
  • 71.61 (n)
zebrafish
(Danio rerio)
Actinopterygii sfmbt2 33 34
  • 62.45 (n)
worm
(Caenorhabditis elegans)
Secernentea mbtr-1 34
  • 19 (a)
ManyToMany
lin-61 34
  • 17 (a)
ManyToMany
Species where no ortholog for SFMBT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SFMBT2 Gene

ENSEMBL:
Gene Tree for SFMBT2 (if available)
TreeFam:
Gene Tree for SFMBT2 (if available)

Paralogs for SFMBT2 Gene

Paralogs for SFMBT2 Gene

(8) SIMAP similar genes for SFMBT2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SFMBT2: view

Variants for SFMBT2 Gene

Sequence variations from dbSNP and Humsavar for SFMBT2 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000003150 -- 7,342,905(-) A/G intron_variant
rs1000019145 -- 7,377,415(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000022720 -- 7,399,307(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000035936 -- 7,311,324(-) C/G intron_variant
rs1000042445 -- 7,249,396(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SFMBT2 Gene

Variant ID Type Subtype PubMed ID
esv1259186 CNV deletion 17803354
esv1635316 CNV insertion 17803354
esv2234111 CNV deletion 18987734
esv2669338 CNV deletion 23128226
esv2732217 CNV deletion 23290073
esv2732228 CNV deletion 23290073
esv2732239 CNV deletion 23290073
esv2732251 CNV deletion 23290073
esv2759732 CNV loss 17122850
esv3545854 CNV deletion 23714750
esv3545857 CNV deletion 23714750
esv3622268 CNV loss 21293372
nsv1038023 CNV gain 25217958
nsv1041863 CNV gain 25217958
nsv1047356 CNV gain 25217958
nsv1069013 CNV deletion 25765185
nsv1133968 CNV deletion 24896259
nsv1137872 CNV deletion 24896259
nsv478772 CNV novel sequence insertion 20440878
nsv517524 CNV loss 19592680
nsv518530 CNV loss 19592680
nsv5731 CNV insertion 18451855
nsv7198 OTHER inversion 18451855
nsv825241 CNV loss 20364138
nsv831777 CNV gain 17160897
nsv831778 CNV loss 17160897
nsv831779 CNV loss 17160897
nsv951245 CNV deletion 24416366

Variation tolerance for SFMBT2 Gene

Residual Variation Intolerance Score: 28.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.19; 69.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SFMBT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SFMBT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFMBT2 Gene

Disorders for SFMBT2 Gene

Additional Disease Information for SFMBT2

No disorders were found for SFMBT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SFMBT2 Gene

Publications for SFMBT2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. Regulation of DU145 prostate cancer cell growth by Scm-like with four mbt domains 2. (PMID: 23385818) Lee K … Ju BG (Journal of biosciences 2013) 3 4 58
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp JJ … Guthrie C (Nature structural & molecular biology 2015) 3 58

Products for SFMBT2 Gene

Sources for SFMBT2 Gene

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