SFMBT2 Gene
protein-coding GIFtS: 43
GCID: GC10M007244
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Scm-like with four mbt domains 2(Previous name: Scm-related gene containing four mbt domains 2 )
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Aliases
for SFMBT2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Scm-Like With Four Mbt Domains 21 2 | | Scm-Related Gene Containing Four Mbt Domains 21 2 | | KIAA16171 3 | | Scm-Like With Four MBT Domains Protein 22 |
Export aliases for SFMBT2 gene to outside databasesPrevious GC identifers: GC10M007354 GC10M007208 |
Summaries
for SFMBT2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SFMBT2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_008705.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SFMBT2 gene promoter:
Max1 c-Fos Sox5 AP-1 Hand1 c-Jun LyF-1 c-Myc E47 YY1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SFMBT2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SFMBT2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10p14 Ensembl cytogenetic band: 10p14 HGNC cytogenetic band: 10p15.1SFMBT2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M007244: view genomic region
(about GC identifiers)
Start:
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7,200,586 bp from pter |
End:
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7,453,450 bp from pter |
Size:
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252,865 bases |
Orientation:
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minus strand |
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Proteins
for SFMBT2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SMBT2_HUMAN, Q5VUG0 (See
protein sequence)Recommended Name: Scm-like with four MBT domains protein 2 Size: 894 amino acids; 100563 Da
Sequence caution: Sequence=BAB13443.1; Type=Erroneous initiation;
1 PDB 3D structure from  and Proteopedia  for SFMBT2:1WJR (3D)
Secondary accessions: A7MD09 Q9HCF5Explore the universe of human proteins at neXtProt for SFMBT2: NX_Q5VUG0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5VUG0
SFMBT2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001018049.1 NP_001025051.1
ENSEMBL proteins: ENSP00000355109 ENSP00000369035 ENSP00000369033 ENSP00000380353 ENSP00000380346
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
SFMBT2 for ontologies About GeneDecksing
SFMBT2 Antibody Products:
Assay Products for SFMBT2: |
Protein
Domains /
Families
for SFMBT2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SFMBT2 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5VUG0ProtoNet protein and cluster: Q5VUG0 2 Blocks protein families: IPB001660 Sterile alpha motif SAM IPB011510 Sterile alpha motif homology 2
UniProtKB/Swiss-Prot: SMBT2_HUMAN, Q5VUG0Similarity: Contains 4 MBT repeatsSimilarity: Contains 1 SAM (sterile alpha motif) domain |
Function
for SFMBT2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFMBT2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFMBT2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for SFMBT2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFMBT2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFMBT2 |
1 GenomeRNAi human phenotype for SFMBT2:
|
Pathways & Interactions
for SFMBT2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SFMBT2
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
SFMBT2 for ontologies About GeneDecksing
|
Drugs & Compounds
for SFMBT2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SFMBT2
Search CenterWatch for drugs/clinical trials and news about SFMBT2 / SMBT2
|
Transcripts
for SFMBT2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SFMBT2 gene (2 alternative transcripts): NM_001018039.1 NM_001029880.2 Unigene Cluster for SFMBT2: Scm-like with four mbt domains 2 Hs.407983 [show with all ESTs]Unigene Representative Sequence: NM_0010298805 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000361972(uc009xio.2 uc001ijn.2 uc010qay.2) ENST00000379713(uc001ijo.2)
ENST00000379711 ENST00000397167 ENST00000397160
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFMBT2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFMBT2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SFMBT2 (NM_001018039) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SFMBT2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFMBT2 |
Additional cDNA sequence: AB046837.1 AK057130.1 AK090887.1 BC067242.1 BC144327.1 BC152430.1 6 DOTS entries: DT.447066 DT.91752573 DT.95257618 DT.100653043 DT.40226939 DT.100709544 24/73 AceView cDNA sequences (see all 73): CD370216 AA908253 BQ447209 BQ430508 AW337774 BQ338003 F12468 AA810182 AA854762 AA573305 AW297182 AB046837 AI273492 BX111766 AI565269 AA370564 AW269652 AA844081 AA687507 AA844438 AA687450 BQ021908 AK090887 AA699392
GeneLoc Exon Structure
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Expression
for SFMBT2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SFMBT2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAACCTTAA
About this image
See SFMBT2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SFMBT2
SOURCE GeneReport for Unigene cluster: Hs.407983
SABiosciences Custom PCR Arrays for SFMBT2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SFMBT2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SFMBT2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SFMBT2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SFMBT2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFMBT2 |
Orthologs
for SFMBT2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SFMBT2 gene from 6/17 species (see all 17) About this table
ENSEMBL Gene Tree for SFMBT2 (if available)
TreeFam Gene Tree for SFMBT2 (if available) |
Paralogs
for SFMBT2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SFMBT2 gene
- L3MBTL12 SCML42 L3MBTL22 ENSG000002605272 L3MBTL32 SFMBT12 L3MBTL42 MBTD12
- SCMH12 SCML22
9 SIMAP similar genes for SFMBT2 using alignment to 3 protein entries: SMBT2_HUMAN (see all proteins):SFMBT1 SFMBT HPH1 SAMD13 L3MBTL2 L3MBTL3
L3MBTL1 SCMH1 L3MBTL4
SFMBT2 for paralogs About GeneDecksing
|
Genomic Variants
for SFMBT2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SFMBT2 (7200586 - 7450586 bp, first 250kb of SFMBT2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SFMBT2
1 CNV: 3791
2 Indels: 48628 44781 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SFMBT2 |
|
Disorders
/ Diseases
for SFMBT2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for SFMBT2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SFMBT2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SFMBT2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2, 3 Nagase T.... Ohara O. (2000)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resi stance. (PubMed id 22581228)1 Manning A.K....Langenberg C. (2012)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for SFMBT2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SFMBT2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing SFMBT2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing SFMBT2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SFMBT2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SFMBT2 gene:
Search GeneIP for patents involving SFMBT2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SFMBT2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SFMBT2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SFMBT2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SFMBT2 | | | OriGene Protein Over-expression Lysate for SFMBT2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SFMBT2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFMBT2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFMBT2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for SFMBT2 |
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 | | | SFMBT2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFMBT2 |
|  |  |  | | | | Search ThermoFisher Antibodies for SFMBT2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFMBT2 |
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