Aliases for SFMBT1 Gene
External Ids for SFMBT1 Gene
Previous GeneCards Identifiers for SFMBT1 Gene
This gene shares high similarity with the Drosophila Scm (sex comb on midleg) gene. It encodes a protein which contains four malignant brain tumor repeat (mbt) domains and may be involved in antigen recognition. [provided by RefSeq, Jun 2012]
GeneCards Summary for SFMBT1 Gene
SFMBT1 (Scm-Like With Four Mbt Domains 1) is a Protein Coding gene. Diseases associated with SFMBT1 include normal pressure hydrocephalus and acute poststreptococcal glomerulonephritis. GO annotations related to this gene include transcription corepressor activity and histone binding. An important paralog of this gene is SCMH1.
UniProtKB/Swiss-Prot for SFMBT1 Gene
Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis.