Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SFMBT1 Gene

protein-coding   GIFtS: 55
GCID: GC03M052913

Scm-Like With Four Mbt Domains 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Scm-Like With Four Mbt Domains 11 2     SFMBT2
Renal Ubiquitous Protein 12 3     Scm-Like With Four MBT Domains Protein 12
RU12 3     Scm-Related Gene Containing Four Mbt Domains2
hSFMBT2 3     Scm-Related Gene Product Containing Four Mbt Domains2

External Ids:    HGNC: 202551   Entrez Gene: 514602   Ensembl: ENSG000001639357   OMIM: 6073195   UniProtKB: Q9UHJ33   

Export aliases for SFMBT1 gene to outside databases

Previous GC identifer: GC03M052895


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SFMBT1 Gene:
This gene shares high similarity with the Drosophila Scm (sex comb on midleg) gene. It encodes a protein which
contains four malignant brain tumor repeat (mbt) domains and may be involved in antigen recognition. (provided by
RefSeq, Jun 2012)

GeneCards Summary for SFMBT1 Gene: 
SFMBT1 (Scm-like with four mbt domains 1) is a protein-coding gene. Diseases associated with SFMBT1 include normal pressure hydrocephalus, and acute poststreptococcal glomerulonephritis. An important paralog of this gene is L3MBTL1.

UniProtKB/Swiss-Prot: SMBT1_HUMAN, Q9UHJ3
Function: Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of
corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a
role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via
interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing
of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SFMBT1 gene promoter:
         Max1   AP-1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSFMBT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SFMBT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SFMBT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.1   Ensembl cytogenetic band:  3p21.1   HGNC cytogenetic band: 3p21.31

SFMBT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SFMBT1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M052913:  view genomic region     (about GC identifiers)

Start:
52,937,583 bp from pter      End:
53,080,766 bp from pter
Size:
143,184 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SMBT1_HUMAN, Q9UHJ3 (See protein sequence)
Recommended Name: Scm-like with four MBT domains protein 1  
Size: 866 amino acids; 98141 Da
Subunit: Interacts with MYOD1 (By similarity). Component of the SLC (SFMBT1-LSD1-CoREST) corepressor complex,
which also contains KDM1A/LSD1 and RCOR1/CoREST. Interacts with KDM1A/LSD1 and RCOR1/CoREST
Subcellular location: Nucleus
Secondary accessions: Q402F7 Q96C73 Q9Y4Q9
Alternative splicing: 2 isoforms:  Q9UHJ3-1   Q9UHJ3-2   

Explore the universe of human proteins at neXtProt for SFMBT1: NX_Q9UHJ3

Explore proteomics data for SFMBT1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UHJ3

  • SFMBT1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SFMBT1 Protein Expression
    REFSEQ proteins: NP_057413.2  
    ENSEMBL proteins: 
     ENSP00000378235   ENSP00000418860   ENSP00000418950   ENSP00000419215   ENSP00000350789  
     ENSP00000296295   ENSP00000378233  

    Human Recombinant Protein Products for SFMBT1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SFMBT1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SFMBT1
    GenScript Custom Purified and Recombinant Proteins Services for SFMBT1
    Novus Biologicals SFMBT1 Proteins
    Novus Biologicals SFMBT1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SFMBT1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17599839

    SFMBT1 for ontologies           About GeneDecksing



    SFMBT1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SFMBT1
    OriGene Custom Antibody Services for SFMBT1
    GenScript Custom Superior Antibodies Services for SFMBT1
    Novus Biologicals SFMBT1 Antibodies
    Abcam antibodies for SFMBT1
    Cloud-Clone Corp. Antibodies for SFMBT1 
    ThermoFisher Antibodies for SFMBT1
    LSBio Antibodies in human, mouse, rat for SFMBT1 

    Assay Products for SFMBT1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SFMBT1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SFMBT1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SFMBT1 
    Cloud-Clone Corp. CLIAs for SFMBT1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SAMD: Sterile alpha motif (SAM) domain containing

    5 InterPro protein domains:
     IPR004092 Mbt
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR021129 SAM_type1
     IPR021987 DUF3588

    Graphical View of Domain Structure for InterPro Entry Q9UHJ3

    ProtoNet protein and cluster: Q9UHJ3

    1 Blocks protein domain: IPB001660 Sterile alpha motif SAM

    UniProtKB/Swiss-Prot: SMBT1_HUMAN, Q9UHJ3
    Domain: The MBT repeats mediate binding to histones tails; however, in contrast to other MBT repeats, does not
    bind specific histone lysine modifications. The MBT repeats lack the conserved Asp and aromatic cage at conserved
    positions (PubMed:23592795)
    Similarity: Contains 4 MBT repeats
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    SFMBT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SMBT1_HUMAN, Q9UHJ3
    Function: Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of
    corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a
    role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via
    interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing
    of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity TAS--
    GO:0005515protein binding IPI17599839
    GO:0042393histone binding IDA17599839
         
    SFMBT1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SFMBT1:
     Increased G2M DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SFMBT1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SFMBT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SFMBT1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SFMBT1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SFMBT1
    8/78 QIAGEN miScript miRNA Assays for microRNAs that regulate SFMBT1 (see all 78):
    hsa-miR-106a hsa-miR-134 hsa-miR-519a hsa-miR-93 hsa-miR-3909 hsa-miR-130b hsa-miR-2113 hsa-miR-20a
    SwitchGear 3'UTR luciferase reporter plasmidSFMBT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SFMBT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SFMBT1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SFMBT1
    Sirion Biotech Customized adenovirus for overexpression of SFMBT1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SFMBT1 (see all 22)
    OriGene ORF clones in mouse, rat for SFMBT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SFMBT1 (NM_001005159)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SFMBT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFMBT1
    Sirion Biotech Customized lentivirus for stable overexpression of SFMBT1 
                         Customized lentivirus expression plasmids for stable overexpression of SFMBT1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SFMBT1
    Search LifeMap BioReagents cell lines for SFMBT1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFMBT1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SFMBT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/38 Interacting proteins for SFMBT1 (Q9UHJ32, 3 ENSP000003507894) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4LP628053, ENSP000003482584I2D: score=1 STRING: ENSP00000348258
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007283spermatogenesis IEA--
    GO:0016568chromatin modification IEA--
    GO:0030154cell differentiation IEA--

    SFMBT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SFMBT1 (SMBT1)

    Search CenterWatch for drugs/clinical trials and news about SFMBT1 / SMBT1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SFMBT1 gene (3 alternative transcripts): 
    NM_016329.3  NM_001005158.2  NM_001005159.2  

    Unigene Cluster for SFMBT1:

    Scm-like with four mbt domains 1
    Hs.343679  [show with all ESTs]
    Unigene Representative Sequence: NM_016329
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394752(uc010hmr.3 uc003dgf.3 uc003dgg.3 uc003dgh.3)
    ENST00000492146 ENST00000482396 ENST00000483069 ENST00000497586 ENST00000470575
    ENST00000474837 ENST00000485494 ENST00000358080 ENST00000296295 ENST00000394750

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SFMBT1
    8/78 QIAGEN miScript miRNA Assays for microRNAs that regulate SFMBT1 (see all 78):
    hsa-miR-106a hsa-miR-134 hsa-miR-519a hsa-miR-93 hsa-miR-3909 hsa-miR-130b hsa-miR-2113 hsa-miR-20a
    SwitchGear 3'UTR luciferase reporter plasmidSFMBT1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SFMBT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SFMBT1
    Clone
    Products:
         
    OriGene clones in human, mouse for SFMBT1 (see all 22)
    OriGene ORF clones in mouse, rat for SFMBT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SFMBT1 (NM_001005159)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SFMBT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFMBT1
    Sirion Biotech Customized lentivirus for stable overexpression of SFMBT1 
                         Customized lentivirus expression plasmids for stable overexpression of SFMBT1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SFMBT1
    OriGene qSTAR qPCR primer pairs in human, mouse for SFMBT1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SFMBT1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SFMBT1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SFMBT1

    Additional mRNA sequence: 

    AB189472.1 AF168132.1 AK313965.1 AL080140.1 BC014614.2 

    15 DOTS entries:

    DT.452381  DT.95254558  DT.99988193  DT.95366754  DT.120926962  DT.40109576  DT.100762142  DT.120927007 
    DT.100675225  DT.120926856  DT.120926932  DT.95366753  DT.99952317  DT.120926912  DT.95070975 

    24/121 AceView cDNA sequences (see all 121):

    AA858062 BG765590 AA723178 CA454348 BC014614 AA284134 BU553665 AI811206 
    CA411693 AW903131 AL080140 AA705472 AA262837 BG768954 AA400743 AA724915 
    BM451549 BE502657 AA400642 AI910465 AI088345 AL523327 BQ581511 R45541 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SFMBT1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:                          -     -                                               -                                                                           
    SP2:                                -                                                                                                                           
    SP3:              -     -     -     -                                                                                                                           
    SP4:                                                                                                                                                            
    SP5:              -     -                                                                                                                                       

    ExUns: 24
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for SFMBT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SFMBT1 expression in normal human tissues (normalized intensities)      SFMBT1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTTAAAAT
    SFMBT1 Expression
    About this image


    SFMBT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Testis (Reproductive System)
             sperm   
     
     Ovary (Reproductive System)
             oocyte   
     
     Blood (Hematopoietic System)
             bone marrow-derived macrophages   
     
     Neural Tube (Nervous System)
             Prosencephalon

    See SFMBT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SFMBT1

    SOURCE GeneReport for Unigene cluster: Hs.343679

    UniProtKB/Swiss-Prot: SMBT1_HUMAN, Q9UHJ3
    Tissue specificity: Expressed in all cell lines and normal tissues tested, including the thymus

        SABiosciences Custom PCR Arrays for SFMBT1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SFMBT1
    OriGene qSTAR qPCR primer pairs in human, mouse for SFMBT1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SFMBT1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SFMBT1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SFMBT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFMBT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SFMBT1 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sfmbt11 , 5 Scm-like with four mbt domains 11, 5 87.06(n)1
    89.11(a)1
      14 (18.99 cM)5
    546501  NM_001166531.11  NP_001160003.11 
     307148495 
    chicken
    (Gallus gallus)
    Aves SFMBT11 Scm-like with four mbt domains 1 76.71(n)
    79.1(a)
      415902  XM_414254.2  XP_414254.1 
    lizard
    (Anolis carolinensis)
    Reptilia SFMBT16
    Scm-like with four mbt domains 1
    77(a)
    1 ↔ 1
    2(155130582-155171363)
    zebrafish
    (Danio rerio)
    Actinopterygii wufc12f052 Transcribed sequence with weak similarity to protein more 72.99(n)    57046738 
    worm
    (Caenorhabditis elegans)
    Secernentea mbtr-16
    lin-616
    Protein lin-61
    16(a)
    16(a)
    many ↔ many
    many ↔ many
    I(343250-348364)
    I(7248828-7251282)


    ENSEMBL Gene Tree for SFMBT1 (if available)
    TreeFam Gene Tree for SFMBT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SFMBT1 gene
    L3MBTL12  L3MBTL22  SCML42  L3MBTL32  SCML12  L3MBTL42  SCMH12  SCML22  
    SFMBT22  MBTD12  
    3 SIMAP similar genes for SFMBT1 using alignment to 4 protein entries:     SMBT1_HUMAN (see all proteins):
    SFMBT2    MBTD1    L3MBTL4

    SFMBT1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2318 SNPs in SFMBT1 are shown (see all 2318)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs679073001,2
    C--52894923(+) TATAT-/ACAC  
            
    ATATA
    1 -- int10--------
    rs1484314361,2
    --52937133(+) GATAAC/TAACAC 1 -- ds50010--------
    rs1871282741,2
    --52937151(+) TAAACA/GTTAAT 1 -- ds50010--------
    rs1895726801,2
    --52937254(+) ACCACC/TACTAC 1 -- ds50010--------
    rs1423850051,2
    --52937284(+) TAATGC/TTAATT 1 -- ds50010--------
    rs1508834061,2
    --52937406(+) TCCCAC/GATAGA 1 -- ds50010--------
    rs361266051,2
    C,F--52937560(+) GGAATG/AGGAAA 1 -- ds50017Minor allele frequency- A:0.14NA WA CSA 248
    rs11345461,2
    C,F,O,H--52937774(-) AGTCAT/CGAGGA 1 -- ut3121Minor allele frequency- C:0.14MN NS EA NA 2200
    rs1819870471,2
    --52937922(+) TCCTCA/GGACTA 1 -- ut310--------
    rs76265511,2
    C,F,A,H--52938092(+) CTGTGG/CTGTGC 1 -- ut3116Minor allele frequency- C:0.42NS EA NA WA CSA 960

    HapMap Linkage Disequilibrium report for SFMBT1 (52937583 - 53080766 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/32 variations for SFMBT1 (see all 32):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv999683CNV Deletion20482838
    esv2489889CNV Deletion19546169
    esv1056402CNV Deletion17803354
    esv2140307CNV Deletion18987734
    esv2672563CNV Deletion23128226
    esv2421449CNV Deletion20811451
    esv2725283CNV Deletion23290073
    esv2725282CNV Deletion23290073
    esv2725281CNV Deletion23290073
    esv2674619CNV Deletion23128226

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SFMBT1
    DNA2.0 Custom Variant and Variant Library Synthesis for SFMBT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607319    OMIM disorders: --

    4 diseases for SFMBT1:    About MalaCards
    normal pressure hydrocephalus    acute poststreptococcal glomerulonephritis    hydrocephalus    glomerulonephritis

    2 diseases from the University of Copenhagen DISEASES database for SFMBT1:
    Normal pressure hydrocephalus     Acute poststreptococcal glomerulonephritis

    SFMBT1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SFMBT1

    Export disorders for SFMBT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SFMBT1 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with SFMBT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells. (PubMed id 10661410)1, 2, 3 Morel S.... Van den Eynde B.J. (2000)
    2. Proteomic and functional analyses reveal the role of chromatin reader SFMBT1 in regulating epigenetic silencing and the myogenic gene program. (PubMed id 23349461)1, 2 Lin S.... Wu L. (2013)
    3. SFMBT1 functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors. (PubMed id 23592795)1, 2 Zhang J.... Reinberg D. (2013)
    4. Human SFMBT is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3. (PubMed id 17599839)1, 2 Wu S....Rice J.C. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. (PubMed id 23263486)1 Kottgen A....Gieger C. (2013)
    7. Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hy pertension susceptibility genes in Han Chinese with a genome-wide gene-based ass ociation study. (PubMed id 22479346)1 Yang H.C....Pan W.H. (2012)
    8. Host-microbe interactions have shaped the genetic arch itecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (2012)
    9. Segmental copy number loss of SFMBT1 gene in elderly individuals with ventriculomegaly: a community-based study. (PubMed id 21325761)1 Kato T....Kawanami T. (2011)
    10. Large-scale genome-wide association analysis of bipol ar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)1 Sklar P....Purcell S.M. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51460 HGNC: 20255 AceView: SFMBT1 Ensembl:ENSG00000163935 euGenes: HUgn51460
    ECgene: SFMBT1 H-InvDB: SFMBT1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SFMBT1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SFMBT1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SFMBT1 gene:
    Search GeneIP for patents involving SFMBT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SFMBT1   OriGene RNAi products in human, mouse, rat for SFMBT1  
     OriGene qPCR primer pairs and template standards for SFMBT1   OriGene Protein Over-expression Lysate for SFMBT1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SFMBT1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SFMBT1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SFMBT1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SFMBT1   OriGene Custom Protein Services for SFMBT1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SFMBT1
     QIAGEN SeqTarget long-range PCR primers for resequencing SFMBT1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SFMBT1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SFMBT1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SFMBT1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SFMBT1
     GenScript Custom Purified and Recombinant Proteins Services for SFMBT1 GenScript cDNA clones with any tag delivered in your preferred vector for SFMBT1
     GenScript Custom Assay Services for SFMBT1 GenScript Custom Superior Antibodies Services for SFMBT1
     GenScript Custom overexpressing Cell Line Services for SFMBT1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SFMBT1 promoter
     Search Chromatin IP Primers for SFMBT1
     RT2 qPCR Primer Assay in human, mouse, rat SFMBT1
     Search GNC Networks for SFMBT1
     SABiosciences Custom PCR Arrays for SFMBT1
     Search Tocris compounds for SFMBT1 (SMBT1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SFMBT1 antibodies
     SFMBT1 proteins
     SFMBT1 lysates
     Antibodies for SFMBT1
     See all of Abcam's Antibodies, Kits and Proteins for SFMBT1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SFMBT1
     Antibodies for SFMBT1
     ELISAs for SFMBT1
     CLIAs for SFMBT1
     Search LifeMap BioReagents cell lines for SFMBT1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFMBT1
     SwitchGear 3'UTR luciferase reporter plasmids for SFMBT1
     SwitchGear Promoter luciferase reporter plasmids for SFMBT1
     ThermoFisher Antibodies for SFMBT1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFMBT1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SFMBT1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SFMBT1
    Customized:
     lentivirus for stable overexpression of SFMBT1
     lentivirus expression plasmids for stable overexpression of SFMBT1
     adenovirus for overexpression of SFMBT1
     LSBio Antibodies in human, mouse, rat for SFMBT1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SFMBT1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4