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Aliases for SFMBT1 Gene

Aliases for SFMBT1 Gene

  • Scm-Like With Four Mbt Domains 1 2 3
  • RU1 3 4 6
  • Renal Ubiquitous Protein 1 3 4
  • HSFMBT 3 4
  • Scm-Related Gene Product Containing Four Mbt Domains 3
  • Scm-Related Gene Containing Four Mbt Domains 3
  • Scm-Like With Four MBT Domains Protein 1 3
  • SFMBT 3

External Ids for SFMBT1 Gene

Previous GeneCards Identifiers for SFMBT1 Gene

  • GC03M052895

Summaries for SFMBT1 Gene

Entrez Gene Summary for SFMBT1 Gene

  • This gene shares high similarity with the Drosophila Scm (sex comb on midleg) gene. It encodes a protein which contains four malignant brain tumor repeat (mbt) domains and may be involved in antigen recognition. [provided by RefSeq, Jun 2012]

GeneCards Summary for SFMBT1 Gene

SFMBT1 (Scm-Like With Four Mbt Domains 1) is a Protein Coding gene. Diseases associated with SFMBT1 include normal pressure hydrocephalus and acute poststreptococcal glomerulonephritis. GO annotations related to this gene include transcription corepressor activity and histone binding. An important paralog of this gene is SCMH1.

UniProtKB/Swiss-Prot for SFMBT1 Gene

  • Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFMBT1 Gene

Genomics for SFMBT1 Gene

Regulatory Elements for SFMBT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SFMBT1 Gene

Start:
52,899,205 bp from pter
End:
53,046,750 bp from pter
Size:
147,546 bases
Orientation:
Minus strand

Genomic View for SFMBT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SFMBT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFMBT1 Gene

Proteins for SFMBT1 Gene

  • Protein details for SFMBT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHJ3-SMBT1_HUMAN
    Recommended name:
    Scm-like with four MBT domains protein 1
    Protein Accession:
    Q9UHJ3
    Secondary Accessions:
    • Q402F7
    • Q96C73
    • Q9Y4Q9

    Protein attributes for SFMBT1 Gene

    Size:
    866 amino acids
    Molecular mass:
    98141 Da
    Quaternary structure:
    • Interacts with MYOD1 (By similarity). Component of the SLC (SFMBT1-LSD1-CoREST) corepressor complex, which also contains KDM1A/LSD1 and RCOR1/CoREST. Interacts with KDM1A/LSD1 and RCOR1/CoREST.

    Alternative splice isoforms for SFMBT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SFMBT1 Gene

Proteomics data for SFMBT1 Gene at MOPED

Post-translational modifications for SFMBT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SFMBT1 Gene

Antibody Products

No data available for DME Specific Peptides for SFMBT1 Gene

Domains for SFMBT1 Gene

Gene Families for SFMBT1 Gene

HGNC:
  • SAMD :Sterile alpha motif (SAM) domain containing

Protein Domains for SFMBT1 Gene

Suggested Antigen Peptide Sequences for SFMBT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UHJ3

UniProtKB/Swiss-Prot:

SMBT1_HUMAN :
  • Q9UHJ3
Domain:
  • The MBT repeats mediate binding to histones tails; however, in contrast to other MBT repeats, does not bind specific histone lysine modifications. The MBT repeats lack the conserved Asp and aromatic cage at conserved positions (PubMed:23592795).
  • Contains 1 SAM (sterile alpha motif) domain.
Similarity:
  • Contains 4 MBT repeats.
genes like me logo Genes that share domains with SFMBT1: view

Function for SFMBT1 Gene

Molecular function for SFMBT1 Gene

UniProtKB/Swiss-Prot Function:
Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis.

Gene Ontology (GO) - Molecular Function for SFMBT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity TAS 23592795
GO:0005515 protein binding IPI 16189514
GO:0042393 histone binding IDA 17599839
genes like me logo Genes that share ontologies with SFMBT1: view

Phenotypes for SFMBT1 Gene

GenomeRNAi human phenotypes for SFMBT1:
genes like me logo Genes that share phenotypes with SFMBT1: view

Animal Model Products

miRNA for SFMBT1 Gene

miRTarBase miRNAs that target SFMBT1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SFMBT1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SFMBT1 Gene

Localization for SFMBT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFMBT1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SFMBT1 Gene COMPARTMENTS Subcellular localization image for SFMBT1 gene
Compartment Confidence
nucleus 3
chloroplast 1
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SFMBT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17599839
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with SFMBT1: view

Pathways for SFMBT1 Gene

SuperPathways for SFMBT1 Gene

No Data Available

Interacting Proteins for SFMBT1 Gene

Gene Ontology (GO) - Biological Process for SFMBT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0007283 spermatogenesis IEA --
GO:0016568 chromatin modification IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with SFMBT1: view

No data available for Pathways by source for SFMBT1 Gene

Transcripts for SFMBT1 Gene

Unigene Clusters for SFMBT1 Gene

Scm-like with four mbt domains 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SFMBT1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SFMBT1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - -
SP2: -
SP3: - - - -
SP4:
SP5: - -
SP6: -

ExUns: 24
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for SFMBT1 Gene

GeneLoc Exon Structure for
SFMBT1
ECgene alternative splicing isoforms for
SFMBT1

Expression for SFMBT1 Gene

mRNA expression in normal human tissues for SFMBT1 Gene

mRNA differential expression in normal tissues according to GTEx for SFMBT1 Gene

This gene is overexpressed in Testis (6.6).

Protein differential expression in normal tissues for SFMBT1 Gene

This gene is overexpressed in Adipocyte (68.3).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SFMBT1 Gene

SOURCE GeneReport for Unigene cluster for SFMBT1 Gene Hs.343679

mRNA Expression by UniProt/SwissProt for SFMBT1 Gene

Q9UHJ3-SMBT1_HUMAN
Tissue specificity: Expressed in all cell lines and normal tissues tested, including the thymus.
genes like me logo Genes that share expressions with SFMBT1: view

Expression partners for SFMBT1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SFMBT1 Gene

Orthologs for SFMBT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SFMBT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SFMBT1 35
  • 92.52 (n)
  • 96.65 (a)
SFMBT1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SFMBT1 35
  • 92.19 (n)
  • 96.54 (a)
SFMBT1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sfmbt1 35
  • 87.06 (n)
  • 89.11 (a)
Sfmbt1 16
Sfmbt1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SFMBT1 35
  • 99.69 (n)
  • 99.65 (a)
SFMBT1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sfmbt1 35
  • 86.44 (n)
  • 88.88 (a)
oppossum
(Monodelphis domestica)
Mammalia SFMBT1 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SFMBT1 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves SFMBT1 35
  • 76.71 (n)
  • 79.1 (a)
SFMBT1 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SFMBT1 36
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii sfmbt1 35
  • 63.47 (n)
  • 63.86 (a)
wufc12f05 35
sfmbt1 36
  • 63 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea lin-61 36
  • 17 (a)
ManyToMany
mbtr-1 36
  • 18 (a)
ManyToMany
Species with no ortholog for SFMBT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SFMBT1 Gene

ENSEMBL:
Gene Tree for SFMBT1 (if available)
TreeFam:
Gene Tree for SFMBT1 (if available)

Paralogs for SFMBT1 Gene

Paralogs for SFMBT1 Gene

Selected SIMAP similar genes for SFMBT1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SFMBT1: view

Variants for SFMBT1 Gene

Sequence variations from dbSNP and Humsavar for SFMBT1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1134546 -- 52,903,758(-) AGTCA(C/T)GAGGA utr-variant-3-prime
rs1579059 -- 52,927,919(-) CCAGG(C/T)TCCAA intron-variant
rs2257216 -- 52,934,710(+) AATAA(C/T)AACGT intron-variant
rs2336160 -- 52,916,705(+) AACAA(A/C)AAAAA intron-variant
rs2336161 -- 52,917,139(+) CTTGG(G/T)ATAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SFMBT1 Gene

Variant ID Type Subtype PubMed ID
esv2674619 CNV Deletion 23128226
esv1056402 CNV Deletion 17803354
nsv3823 CNV Loss 18451855
dgv1457e1 CNV Complex 17122850
nsv876799 CNV Loss 21882294
esv29989 CNV Loss 17803354
nsv517046 CNV Gain+Loss 19592680
nsv437713 CNV Loss 16327808
esv999683 CNV Deletion 20482838
esv26966 CNV Loss 19812545
esv2725281 CNV Deletion 23290073
nsv822093 CNV Loss 20364138
dgv107e180 CNV Loss 20482838
nsv499000 CNV Loss 21111241
dgv862e199 CNV Deletion 23128226
nsv514151 CNV Loss 21397061
nsv460538 CNV Loss 19166990
dgv603n27 CNV Loss 19166990
nsv818140 CNV Loss 17921354
esv2421449 CNV Deletion 20811451
nsv442860 CNV CNV 18776908
nsv438398 CNV Loss 16468122
nsv876800 CNV Loss 21882294
esv2489889 CNV Deletion 19546169
esv2672563 CNV Deletion 23128226
esv22089 CNV Loss 19812545
nsv822094 CNV Gain 20364138
esv2725282 CNV Deletion 23290073
esv2140307 CNV Deletion 18987734
esv2660654 CNV Deletion 23128226
esv2725283 CNV Deletion 23290073
esv26488 CNV Loss 19812545

Relevant External Links for SFMBT1 Gene

HapMap Linkage Disequilibrium report
SFMBT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFMBT1 Gene

Disorders for SFMBT1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SFMBT1 Gene in MalaCards »

(2) Diseases for SFMBT1 Gene including...

Relevant External Links for SFMBT1

Genetic Association Database (GAD)
SFMBT1
genes like me logo Genes that share disorders with SFMBT1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for SFMBT1 Gene

Publications for SFMBT1 Gene

  1. Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells. (PMID: 10661410) Morel S. … Van den Eynde B.J. (Immunity 2000) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Human SFMBT is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3. (PMID: 17599839) Wu S. … Rice J.C. (FEBS Lett. 2007) 3 4
  4. Proteomic and functional analyses reveal the role of chromatin reader SFMBT1 in regulating epigenetic silencing and the myogenic gene program. (PMID: 23349461) Lin S. … Wu L. (J. Biol. Chem. 2013) 3 4
  5. SFMBT1 functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors. (PMID: 23592795) Zhang J. … Reinberg D. (Genes Dev. 2013) 3 4

Products for SFMBT1 Gene

Sources for SFMBT1 Gene

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