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SFI1 Gene

protein-coding   GIFtS: 50
GCID: GC22P031884

Sfi1 Homolog, Spindle Assembly Associated (Yeast)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sfi1 Homolog, Spindle Assembly Associated (Yeast)1 2     Homolog Of Yeast Sfi12
KIAA05423 5     Protein SFI1 Homolog2
PISD2     hSFI13
hSfi1p2     

External Ids:    HGNC: 290641   Entrez Gene: 98142   Ensembl: ENSG000001980897   OMIM: 6127655   UniProtKB: A8K8P33   

Export aliases for SFI1 gene to outside databases

Previous GC identifers: GC22P030217 GC22P014853


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SFI1 Gene:
SFI1 (Sfi1 homolog, spindle assembly associated (yeast)) is a protein-coding gene. GO annotations related to this gene include phosphatase binding.

UniProtKB/Swiss-Prot: SFI1_HUMAN, A8K8P3
Function: Plays a role in the dynamic structure of centrosome-associated contractile fibers via its interaction
with CETN2




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SFI1 gene promoter:
         Bach1   HOXA9B   HOXA9   Sp1   Lmo2   Meis-1a   Meis-1   Meis-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSFI1 promoter sequence
   Search Chromatin IP Primers for SFI1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SFI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.2

SFI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SFI1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P031884:  view genomic region     (about GC identifiers)

Start:
31,884,674 bp from pter      End:
32,014,572 bp from pter
Size:
129,899 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SFI1_HUMAN, A8K8P3 (See protein sequence)
Recommended Name: Protein SFI1 homolog  
Size: 1242 amino acids; 147664 Da
Subunit: Interacts with CETN2 (via C-terminus)
Caution: It is uncertain whether Met-1 or Met-24 is the initiator
Sequence caution: Sequence=AAI10815.1; Type=Erroneous initiation; Sequence=AAI29927.1; Type=Erroneous initiation;
Sequence=BAA25468.2; Type=Erroneous initiation; Sequence=CAH70755.2; Type=Erroneous initiation;
Sequence=CAI23034.2; Type=Erroneous initiation; Sequence=CAM13202.2; Type=Erroneous initiation;
Sequence=CAM14701.1; Type=Erroneous gene model prediction; Sequence=CAM28334.2; Type=Erroneous initiation;
Sequence=CAX14857.1; Type=Erroneous initiation; Sequence=CAX14858.1; Type=Erroneous initiation;
Sequence=CAX15240.1; Type=Erroneous initiation; Sequence=CAX15241.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for SFI1:
2K2I (3D)    
Secondary accessions: A1L373 A1L387 A2A2L2 B1AKL9 B5MDB7 B7Z1V6 B7Z8G3 B7ZBE2 B7ZBE3 O60289
Q2TAN8 Q5W1B5 Q86TK0 Q8N4U8 Q8N8C1 Q8WU14
Alternative splicing: 7 isoforms:  A8K8P3-1   A8K8P3-2   A8K8P3-3   A8K8P3-4   A8K8P3-5   A8K8P3-9   A8K8P3-10   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SFI1: NX_A8K8P3

Explore proteomics data for SFI1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SFI1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001007468.1  NP_001245254.1  NP_001245255.1  NP_001245256.1  NP_055590.2  

    ENSEMBL proteins: 
     ENSP00000402679   ENSP00000401199   ENSP00000391339   ENSP00000383146   ENSP00000411793  
     ENSP00000383145   ENSP00000430488   ENSP00000389364   ENSP00000405541   ENSP00000398871  
     ENSP00000416931   ENSP00000443025   ENSP00000416469   ENSP00000397148  
    Reactome Protein details: A8K8P3

    SFI1 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SFI1

     
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    antibodies-online proteins for SFI1 (2 products) 

     
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    SFI1 Antibody Products:

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    antibodies-online antibodies for SFI1 (3 products) 

    SFI1 Assay Products:

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    Cloud-Clone Corp. ELISAs for SFI1
    Cloud-Clone Corp. CLIAs for SFI1
    Search eBioscience for ELISAs for SFI1 
    antibodies-online kits for SFI1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026174 SFI1/KIAA1407

    Graphical View of Domain Structure for InterPro Entry A8K8P3

    ProtoNet protein and cluster: A8K8P3

    UniProtKB/Swiss-Prot: SFI1_HUMAN, A8K8P3
    Domain: CETN2-binding regions contains a conserved Trp residue in their C-terminal ends, which seems critical for
    interaction with CETN2
    Similarity: Belongs to the SFI1 family
    Similarity: Contains 6 HAT repeats


    Find genes that share domains with SFI1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SFI1_HUMAN, A8K8P3
    Function: Plays a role in the dynamic structure of centrosome-associated contractile fibers via its interaction
    with CETN2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16956364
    GO:0019902phosphatase binding IDA19389623
         
    Find genes that share ontologies with SFI1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SFI1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SFI1:
    hsa-mir-1 (MIRT023645)

    Block miRNA regulation of human, mouse, rat SFI1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate SFI1:
    hsa-miR-579 hsa-miR-203 hsa-miR-4254 hsa-miR-302f hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidSFI1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SFI1
    Predesigned siRNA for gene silencing in human, mouse, rat SFI1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SFI1

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): SFI1 (NM_014775)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SFI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFI1

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    Browse ESI BIO Cell Lines and PureStem Progenitors for SFI1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFI1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SFI1_HUMAN, A8K8P3: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
    Note=Localized close to the centriole
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005814centriole IEA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with SFI1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SFI1 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Regulation of PLK1 Activity at G2/M Transition0.77
    Loss of Nlp from mitotic centrosomes0.86
    G2/M Transition0.70
    Centrosome maturation0.86
    Mitotic G2-G2/M phases0.69
    Loss of proteins required for interphase microtubule organizationfrom the centrosome0.86
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90


    Find genes that share SuperPaths with SFI1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 Reactome Pathways for SFI1
        Recruitment of mitotic centrosome proteins and complexes
    Loss of proteins required for interphase microtubule organization,from the centrosome
    Regulation of PLK1 Activity at G2/M Transition
    Loss of Nlp from mitotic centrosomes


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SFI1
    Interactions:

        Search GeneGlobe Interaction Network for SFI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SFI1 (A8K8P31, 3 ENSP000003831454) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CETN2P412081, 3, ENSP000003593004EBI-743371,EBI-1789926 I2D: score=4 STRING: ENSP00000359300
    RADILQ96JH83, ENSP000003824924I2D: score=4 STRING: ENSP00000382492
    CDC5LQ994593, ENSP000003605324I2D: score=1 STRING: ENSP00000360532
    KRT19P087273, ENSP000003551244I2D: score=4 STRING: ENSP00000355124
    MDFIQ997503, ENSP000002303214I2D: score=4 STRING: ENSP00000230321
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0010923negative regulation of phosphatase activity IDA19389623

    Find genes that share ontologies with SFI1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SFI1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SFI1 gene (5 alternative transcripts): 
    NM_001007467.2  NM_001258325.1  NM_001258326.1  NM_001258327.1  NM_014775.3  

    Unigene Cluster for SFI1:

    Sfi1 homolog, spindle assembly associated (yeast)
    Hs.62209  [show with all ESTs]
    Unigene Representative Sequence: NM_001007467
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31):
    ENST00000465646 ENST00000432498(uc003ale.3 uc003alf.3 uc011alq.2)
    ENST00000443011 ENST00000465437 ENST00000411518 ENST00000400289(uc010gwi.3)
    ENST00000444859 ENST00000400288 ENST00000382162 ENST00000524296 ENST00000450787
    ENST00000486708 ENST00000476010 ENST00000484806 ENST00000452250 ENST00000478887
    ENST00000467357 ENST00000417682
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate SFI1:
    hsa-miR-579 hsa-miR-203 hsa-miR-4254 hsa-miR-302f hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidSFI1 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat SFI1
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SFI1 (NM_014775)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SFI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFI1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SFI1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SFI1
      QuantiTect SYBR Green Assays in human, mouse, rat SFI1
      QuantiFast Probe-based Assays in human, mouse, rat SFI1

    Additional mRNA sequence: 

    AB011114.2 AK055147.1 AK292408.1 AK293987.1 AK303362.1 BC021576.1 BC110814.1 BC129926.1 
    BC129945.1 

    Selected DOTS entries (see all 27):

    DT.99999996  DT.86854433  DT.97821139  DT.456181  DT.100037354  DT.99965256  DT.100648845  DT.120664312 
    DT.95320956  DT.100037355  DT.120664403  DT.100837469  DT.75181387  DT.97804862  DT.120664227  DT.92441000 
    DT.100830137  DT.120664415  DT.86845325  DT.100799049  DT.120664221  DT.120664305  DT.120664368  DT.95189271 

    Selected AceView cDNA sequences (see all 153):

    BC046221 CA391527 BG221765 BQ182132 AI358343 BI831061 AB011114 BC041101 
    AI824779 BC033613 BG058708 BM264492 BM990783 AW263982 H55415 AW469318 
    AI425026 BG767619 BC021576 BI962786 AI806913 BM850285 BU193643 AA909861 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SFI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTGCGGGG
    SFI1 Expression
    About this image


    SFI1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             Chondrocytes Tracheal Cartilage
             Lung Mesoderm
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Limb Muscle Progenitor Cells Forelimb Myotome
             Pelvic Girdle
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             Pelvic Girdle
     
     Gonad
             Primordial Germ Cells Allantois
    SFI1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SFI1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.62209
        Custom PCR Arrays for SFI1
    Primer
    Products:
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFI1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SFI1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sfi11 , 5 Sfi1 homolog, spindle assembly associated (yeast)1, 5 76.22(n)1
    65.83(a)1
      11 (2.19 cM)5
    788871  NM_030207.21  NP_084483.21 
     31318505 
    chicken
    (Gallus gallus)
    Aves SFI11 Sfi1 homolog, spindle assembly associated (yeast) 50.03(n)
    38.18(a)
      427706  XM_004934363.1  XP_004934420.1 
    lizard
    (Anolis carolinensis)
    Reptilia SFI16
    Sfi1 homolog, spindle assembly associated (yeast)
    32(a)
    1 ↔ 1
    3(143103870-143131127)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sfi11 Sfi1 homolog, spindle assembly associated 49.77(n)
    37.42(a)
      100380177  XM_004910594.1  XP_004910651.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sfi11 Sfi1 homolog, spindle assembly associated (yeast) 43.42(n)
    29.23(a)
      560147  XM_683537.5  XP_688629.5 


    ENSEMBL Gene Tree for SFI1 (if available)
    TreeFam Gene Tree for SFI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SFI1 (see all 2709)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs668256111,2
    C--31890136(+) AAAAA-/G/GAA 
            
    AAAAG
    10 -- us2k1 cds10--------
    rs1380292771,2
    --31890155(+) CTAGAA/TACCCA 5 -- us2k10--------
    rs2004739251,2
    C--31890299(+) CTTAGA/TTTTTT 5 -- us2k10--------
    rs113760641,2
    C--31890302(+) GATTTT/-TTTTT 5 -- us2k1 trp31Minor allele frequency- -:0.00NA 2
    rs1909207891,2
    --31890326(+) AGTCTC/TGCTCT 5 -- us2k10--------
    rs1137756591,2
    C,F--31890478(+) TTAGTA/GGTAGA 5 -- us2k12Minor allele frequency- G:0.06WA 120
    rs96092951,2
    C,F,A--31890577(+) TAGGCG/ATGAGC 5 -- us2k12Minor allele frequency- A:0.50NA 4
    rs96192021,2
    C,F,H--31890765(+) TACTAT/CTATCT 5 -- us2k18Minor allele frequency- C:0.03NS EA NA 1064
    rs574949131,2
    C--31891053(+) TTAAAACT/-ACTTG 5 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1152244861,2
    --31891155(+) ATTATC/TGAGAC 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for SFI1 (31884674 - 32014572 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SFI1 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1485049CNV Deletion17803354
    esv2663679CNV Deletion23128226
    esv1430494CNV Deletion17803354
    esv1626782CNV Deletion17803354
    esv1038327CNV Deletion17803354
    esv2724142CNV Deletion23290073
    esv2724141CNV Deletion23290073
    esv268751CNV Insertion20981092
    nsv3594CNV Insertion18451855
    nsv914980CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612765    OMIM disorders: --


    Find genes that share disorders with SFI1           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: SFI1 (1 document)

    Export disorders for SFI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SFI1 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with SFI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sfi1p has conserved centrin-binding sites and an essential function in budding yeast spindle pole body duplication. (PubMed id 14504268)1, 2, 3 Kilmartin J.V. (J. Cell Biol. 2003)
    2. Binding of human centrin 2 to the centrosomal protein hSfi1. (PubMed id 16956364)1, 2 Martinez-Sanz J....Craescu C.T. (FEBS J. 2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (DNA Res. 1998)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    7. A whole genome screen for HIV restriction factors. (PubMed id 22082156)1 Liu L....McKnight A. (Retrovirology 2011)
    8. Structure, dynamics and thermodynamics of the human centrin 2/hSfi1 complex. (PubMed id 19857500)1 Martinez-Sanz J....Craescu C.T. (J. Mol. Biol. 2010)
    9. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PubMed id 19389623)1 Hendrickx A.... Bollen M. (Chem. Biol. 2009)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9814 HGNC: 29064 AceView: SFI1 Ensembl:ENSG00000198089 euGenes: HUgn9814
    ECgene: SFI1 H-InvDB: SFI1

    (According to HUGE)
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    HUGE: KIAA0542

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SFI1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SFI1 gene:
    Search GeneIP for patents involving SFI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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