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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SFI1 Gene

protein-coding   GIFtS: 48
GCID: GC22P031884

Sfi1 Homolog, Spindle Assembly Associated (Yeast)

  Search for SFI1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sfi1 Homolog, Spindle Assembly Associated (Yeast)1 2     Homolog Of Yeast Sfi12
KIAA05423 5     Protein SFI1 Homolog2
PISD2     hSFI13
hSfi1p2     

External Ids:    HGNC: 290641   Entrez Gene: 98142   Ensembl: ENSG000001980897   OMIM: 6127655   UniProtKB: A8K8P33   

Export aliases for SFI1 gene to outside databases

Previous GC identifers: GC22P030217 GC22P014853


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SFI1 Gene: 
SFI1 (Sfi1 homolog, spindle assembly associated (yeast)) is a protein-coding gene. Among its related super-pathways are G2/M Transition and Cell Cycle, Mitotic. GO annotations related to this gene include phosphatase binding and protein binding.

UniProtKB/Swiss-Prot: SFI1_HUMAN, A8K8P3
Function: Plays a role in the dynamic structure of centrosome-associated contractile fibers via its interaction
with CETN2




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SFI1 gene promoter:
         Bach1   HOXA9B   HOXA9   Sp1   Lmo2   Meis-1a   Meis-1   Meis-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSFI1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SFI1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SFI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.2

SFI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SFI1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P031884:  view genomic region     (about GC identifiers)

Start:
31,884,674 bp from pter      End:
32,014,572 bp from pter
Size:
129,899 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SFI1_HUMAN, A8K8P3 (See protein sequence)
Recommended Name: Protein SFI1 homolog  
Size: 1242 amino acids; 147664 Da
Subunit: Interacts with CETN2 (via C-terminus)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Note=Localized close to the centriole
Caution: It is uncertain whether Met-1 or Met-24 is the initiator
Sequence caution: Sequence=AAI10815.1; Type=Erroneous initiation; Sequence=AAI29927.1; Type=Erroneous initiation;
Sequence=BAA25468.2; Type=Erroneous initiation; Sequence=CAH70755.2; Type=Erroneous initiation;
Sequence=CAI23034.2; Type=Erroneous initiation; Sequence=CAM13202.2; Type=Erroneous initiation;
Sequence=CAM14701.1; Type=Erroneous gene model prediction; Sequence=CAM28334.2; Type=Erroneous initiation;
Sequence=CAX14857.1; Type=Erroneous initiation; Sequence=CAX14858.1; Type=Erroneous initiation;
Sequence=CAX15240.1; Type=Erroneous initiation; Sequence=CAX15241.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for SFI1:
2K2I (3D)    
Secondary accessions: A1L373 A1L387 A2A2L2 B1AKL9 B5MDB7 B7Z1V6 B7Z8G3 B7ZBE2 B7ZBE3 O60289
Q2TAN8 Q5W1B5 Q86TK0 Q8N4U8 Q8N8C1 Q8WU14
Alternative splicing: 7 isoforms:  A8K8P3-1   A8K8P3-2   A8K8P3-3   A8K8P3-4   A8K8P3-5   A8K8P3-9   A8K8P3-10   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SFI1: NX_A8K8P3

Explore proteomics data for SFI1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A8K8P3

  • SFI1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SFI1 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001007468.1  NP_001245254.1  NP_001245255.1  NP_001245256.1  NP_055590.2  

    ENSEMBL proteins: 
     ENSP00000402679   ENSP00000401199   ENSP00000391339   ENSP00000383146   ENSP00000411793  
     ENSP00000383145   ENSP00000430488   ENSP00000389364   ENSP00000405541   ENSP00000398871  
     ENSP00000416931   ENSP00000443025   ENSP00000416469   ENSP00000397148  
    Reactome Protein details: A8K8P3
    Human Recombinant Protein Products for SFI1: 
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    Novus Biologicals SFI1 Protein
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SFI1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005814centriole IEA--
    GO:0005829cytosol TAS--

    SFI1 for ontologies           About GeneDecksing



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    Assay Products for SFI1: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: A8K8P3

    UniProtKB/Swiss-Prot: SFI1_HUMAN, A8K8P3
    Domain: CETN2-binding regions contains a conserved Trp residue in their C-terminal ends, which seems critical for
    interaction with CETN2
    Similarity: Belongs to the SFI1 family
    Similarity: Contains 6 HAT repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SFI1_HUMAN, A8K8P3
    Function: Plays a role in the dynamic structure of centrosome-associated contractile fibers via its interaction
    with CETN2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16956364
    GO:0019902phosphatase binding IDA19389623
         
    SFI1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SFI1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SFI1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SFI1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SFI1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target SFI1:
    hsa-mir-16 (MIRT001431)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SFI1
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate SFI1:
    hsa-miR-579 hsa-miR-203 hsa-miR-4254 hsa-miR-302f hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidSFI1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFI1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SFI1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Recruitment of mitotic centrosome proteins and complexes
    Recruitment of mitotic centrosome proteins and complexes0.83
    Mitotic G2-G2/M phases0.81
    Centrosome maturation0.83
    Loss of Nlp from mitotic centrosomes0.78
    G2/M Transition0.83
    Loss of proteins required for interphase microtubule organization,from the centrosome0.78
    2Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/8        Reactome Pathways for SFI1 (see all 8)
        Centrosome maturation
    Cell Cycle
    Recruitment of mitotic centrosome proteins and complexes
    G2/M Transition
    Loss of proteins required for interphase microtubule organization,from the centrosome



    SFI1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SFI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/62 Interacting proteins for SFI1 (A8K8P31, 3 ENSP000003831454) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CETN2P412081, 3, ENSP000003593004EBI-743371,EBI-1789926 I2D: score=4 STRING: ENSP00000359300
    RADILQ96JH83, ENSP000003824924I2D: score=4 STRING: ENSP00000382492
    CDC5LQ994593, ENSP000003605324I2D: score=1 STRING: ENSP00000360532
    KRT19P087273, ENSP000003551244I2D: score=4 STRING: ENSP00000355124
    MDFIQ997503, ENSP000002303214I2D: score=4 STRING: ENSP00000230321
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0010923negative regulation of phosphatase activity IDA19389623

    SFI1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SFI1

    Search CenterWatch for drugs/clinical trials and news about SFI1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SFI1 gene (5 alternative transcripts): 
    NM_001007467.2  NM_001258325.1  NM_001258326.1  NM_001258327.1  NM_014775.3  

    Unigene Cluster for SFI1:

    Sfi1 homolog, spindle assembly associated (yeast)
    Hs.62209  [show with all ESTs]
    Unigene Representative Sequence: NM_001007467
    18/31 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31):
    ENST00000465646 ENST00000432498(uc003ale.3 uc003alf.3 uc011alq.2)
    ENST00000443011 ENST00000465437 ENST00000411518 ENST00000400289(uc010gwi.3)
    ENST00000444859 ENST00000400288 ENST00000382162 ENST00000524296 ENST00000450787
    ENST00000486708 ENST00000476010 ENST00000484806 ENST00000452250 ENST00000478887
    ENST00000467357 ENST00000417682
    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate SFI1:
    hsa-miR-579 hsa-miR-203 hsa-miR-4254 hsa-miR-302f hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidSFI1 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SFI1
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SFI1 (NM_014775)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SFI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFI1
    Sirion Biotech Customized lentivirus for stable overexpression of SFI1 
                         Customized lentivirus expression plasmids for stable overexpression of SFI1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SFI1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SFI1

    Additional mRNA sequence: 

    AB011114.2 AK055147.1 AK292408.1 AK293987.1 AK303362.1 BC021576.1 BC110814.1 BC129926.1 
    BC129945.1 

    24/27 DOTS entries (see all 27):

    DT.99999996  DT.86854433  DT.97821139  DT.456181  DT.100037354  DT.99965256  DT.100648845  DT.120664312 
    DT.95320956  DT.100037355  DT.120664403  DT.100837469  DT.75181387  DT.97804862  DT.120664227  DT.92441000 
    DT.100830137  DT.120664415  DT.86845325  DT.100799049  DT.120664221  DT.120664305  DT.120664368  DT.95189271 

    24/153 AceView cDNA sequences (see all 153):

    BU193643 AA909861 BU738445 BC046221 CA391527 BG221765 BQ182132 AI358343 
    BI831061 AB011114 BC041101 AI824779 BC033613 BG058708 BM264492 BM990783 
    AW263982 H55415 AW469318 AI425026 BG767619 BC021576 BI962786 AI806913 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SFI1 expression in normal human tissues (normalized intensities)      SFI1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTGCGGGG
    SFI1 Expression
    About this image


    SFI1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Lung (Respiratory System)    fully expand to see all 4 entries
             Chondrocytes Tracheal Cartilage
             Lung Mesoderm
             visceral organ/lung/left lung   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             skeleton/pectoral girdle and thoracic body wall   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             skeleton/pectoral girdle and thoracic body wall   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Limb Muscle Progenitor Cells Forelimb Myotome
             Pelvic Girdle
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             t cells   

    See SFI1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SFI1

    SOURCE GeneReport for Unigene cluster: Hs.62209
        SABiosciences Custom PCR Arrays for SFI1
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFI1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SFI1 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sfi11 , 5 Sfi1 homolog, spindle assembly associated (yeast)1, 5 76.22(n)1
    65.83(a)1
      11 (2.19 cM)5
    788871  NM_030207.21  NP_084483.21 
     31318505 
    chicken
    (Gallus gallus)
    Aves SFI11 Sfi1 homolog, spindle assembly associated (yeast) 50.21(n)
    38.96(a)
      427706  XM_425281.3  XP_425281.3 
    lizard
    (Anolis carolinensis)
    Reptilia SFI16
    Uncharacterized protein
    32(a)
    1 ↔ 1
    3(143103870-143131127)
    zebrafish
    (Danio rerio)
    Actinopterygii sfi11 Sfi1 homolog, spindle assembly associated (yeast) 43.83(n)
    29.56(a)
      560147  XM_683537.4  XP_688629.4 


    ENSEMBL Gene Tree for SFI1 (if available)
    TreeFam Gene Tree for SFI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2709 SNPs in SFI1 are shown (see all 2709)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs668256111,2
    C--31890136(+) AAAAA-/G/GAA 
            
    AAAAG
    10 -- us2k1 cds10--------
    rs1380292771,2
    --31890155(+) CTAGAA/TACCCA 5 -- us2k10--------
    rs2004739251,2
    C--31890299(+) CTTAGA/TTTTTT 5 -- us2k10--------
    rs113760641,2
    C--31890302(+) GATTTT/-TTTTT 5 -- us2k1 trp31Minor allele frequency- -:0.00NA 2
    rs1909207891,2
    --31890326(+) AGTCTC/TGCTCT 5 -- us2k10--------
    rs1137756591,2
    C,F--31890478(+) TTAGTA/GGTAGA 5 -- us2k12Minor allele frequency- G:0.06WA 120
    rs96092951,2
    C,F,A--31890577(+) TAGGCG/ATGAGC 5 -- us2k12Minor allele frequency- A:0.50NA 4
    rs96192021,2
    C,F,H--31890765(+) TACTAT/CTATCT 5 -- us2k18Minor allele frequency- C:0.03NS EA NA 1064
    rs574949131,2
    C--31891053(+) TTAAAACT/-ACTTG 5 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1152244861,2
    --31891155(+) ATTATC/TGAGAC 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for SFI1 (31884674 - 32014572 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for SFI1 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1485049CNV Deletion17803354
    esv2663679CNV Deletion23128226
    esv1430494CNV Deletion17803354
    esv1626782CNV Deletion17803354
    esv1038327CNV Deletion17803354
    esv2724142CNV Deletion23290073
    esv2724141CNV Deletion23290073
    esv268751CNV Insertion20981092
    nsv3594CNV Insertion18451855
    nsv914980CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SFI1 for disorders           About MalaCards
    OMIM gene information: 612765    OMIM disorders: --


    SFI1 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: SFI1 (1 document)

    Export disorders for SFI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SFI1 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with SFI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sfi1p has conserved centrin-binding sites and an essential function in budding yeast spindle pole body duplication. (PubMed id 14504268)1, 2, 3 Kilmartin J.V. (2003)
    2. Binding of human centrin 2 to the centrosomal protein hSfi1. (PubMed id 16956364)1, 2 Martinez-Sanz J....Craescu C.T. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (1998)
    5. Structure, dynamics and thermodynamics of the human c entrin 2/hSfi1 complex. (PubMed id 19857500)1 Martinez-Sanz J....Craescu C.T. (2010)
    6. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PubMed id 19389623)1 Hendrickx A.... Bollen M. (2009)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation. (PubMed id 16462731)1 Petretti C....Giet R. (2006)
    9. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    10. Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. (PubMed id 16009131)1 Carroll J.S....Brown M. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9814 HGNC: 29064 AceView: SFI1 Ensembl:ENSG00000198089 euGenes: HUgn9814
    ECgene: SFI1 H-InvDB: SFI1

    (According to HUGE)
    About This Section
    HUGE: KIAA0542

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SFI1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SFI1 gene:
    Search GeneIP for patents involving SFI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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