Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SFI1 Gene

Aliases for SFI1 Gene

  • SFI1 Centrin Binding Protein 2 3 5
  • Sfi1 Homolog, Spindle Assembly Associated (Yeast) 2
  • Protein Phosphatase 1, Regulatory Subunit 139 3
  • Sfi1 Homolog, Spindle Assembly Associated 3
  • Regulatory Subunit 139 2
  • Protein Phosphatase 1 2
  • Homolog Of Yeast Sfi1 3
  • PPP1R139 3
  • KIAA0542 4
  • HSfi1p 3
  • HSFI1 4
  • PISD 3

External Ids for SFI1 Gene

Previous GeneCards Identifiers for SFI1 Gene

  • GC22P030217
  • GC22P031884
  • GC22P014853

Summaries for SFI1 Gene

GeneCards Summary for SFI1 Gene

SFI1 (SFI1 Centrin Binding Protein) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Organelle biogenesis and maintenance. GO annotations related to this gene include phosphatase binding.

UniProtKB/Swiss-Prot for SFI1 Gene

  • Plays a role in the dynamic structure of centrosome-associated contractile fibers via its interaction with CETN2.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFI1 Gene

Genomics for SFI1 Gene

Regulatory Elements for SFI1 Gene

Enhancers for SFI1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SFI1 on UCSC Golden Path with GeneCards custom track

Promoters for SFI1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SFI1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SFI1 Gene

31,488,688 bp from pter
31,618,586 bp from pter
129,899 bases
Plus strand

Genomic View for SFI1 Gene

Genes around SFI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFI1 Gene

Proteins for SFI1 Gene

  • Protein details for SFI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein SFI1 homolog
    Protein Accession:
    Secondary Accessions:
    • A1L373
    • A1L387
    • A2A2L2
    • B1AKL9
    • B5MDB7
    • B7Z1V6
    • B7Z8G3
    • B7ZBE2
    • B7ZBE3
    • O60289
    • Q2TAN8
    • Q5W1B5
    • Q86TK0
    • Q8N4U8
    • Q8N8C1
    • Q8WU14

    Protein attributes for SFI1 Gene

    1242 amino acids
    Molecular mass:
    147664 Da
    Quaternary structure:
    • Interacts with CETN2 (via C-terminus).
    • Sequence=AAI10815.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI29927.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA25468.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH70755.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI23034.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAM13202.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAM14701.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM28334.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAX14857.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAX14858.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAX15240.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAX15241.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SFI1 Gene

    Alternative splice isoforms for SFI1 Gene

neXtProt entry for SFI1 Gene

Proteomics data for SFI1 Gene at MOPED

Post-translational modifications for SFI1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SFI1 Gene

Domains & Families for SFI1 Gene

Gene Families for SFI1 Gene

Protein Domains for SFI1 Gene


Graphical View of Domain Structure for InterPro Entry



  • CETN2-binding regions contains a conserved Trp residue in their C-terminal ends, which seems critical for interaction with CETN2.
  • Belongs to the SFI1 family.
  • Contains 6 HAT repeats.
  • CETN2-binding regions contains a conserved Trp residue in their C-terminal ends, which seems critical for interaction with CETN2.
  • Belongs to the SFI1 family.
  • Contains 6 HAT repeats.
genes like me logo Genes that share domains with SFI1: view

Function for SFI1 Gene

Molecular function for SFI1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the dynamic structure of centrosome-associated contractile fibers via its interaction with CETN2.

Phenotypes for SFI1 Gene

genes like me logo Genes that share phenotypes with SFI1: view

Animal Model Products

miRNA for SFI1 Gene

miRTarBase miRNAs that target SFI1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SFI1 Gene

Localization for SFI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFI1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localized close to the centriole.

Subcellular locations from

Jensen Localization Image for SFI1 Gene COMPARTMENTS Subcellular localization image for SFI1 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for SFI1 Gene

Pathways & Interactions for SFI1 Gene

genes like me logo Genes that share pathways with SFI1: view

Gene Ontology (GO) - Biological Process for SFI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
genes like me logo Genes that share ontologies with SFI1: view

No data available for SIGNOR curated interactions for SFI1 Gene

Drugs & Compounds for SFI1 Gene

No Compound Related Data Available

Transcripts for SFI1 Gene

Unigene Clusters for SFI1 Gene

Sfi1 homolog, spindle assembly associated (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SFI1 Gene

No ASD Table

Relevant External Links for SFI1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SFI1 Gene

mRNA expression in normal human tissues for SFI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SFI1 Gene

This gene is overexpressed in Brain - Cerebellum (x4.3) and Brain - Cerebellar Hemisphere (x4.1).

Protein differential expression in normal tissues from HIPED for SFI1 Gene

This gene is overexpressed in Rectum (64.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SFI1 Gene

SOURCE GeneReport for Unigene cluster for SFI1 Gene Hs.62209

genes like me logo Genes that share expression patterns with SFI1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SFI1 Gene

Orthologs for SFI1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SFI1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SFI1 35
  • 77.79 (n)
  • 67.04 (a)
SFI1 36
  • 66 (a)
(Canis familiaris)
Mammalia SFI1 35
  • 82.57 (n)
  • 74.09 (a)
SFI1 36
  • 73 (a)
(Mus musculus)
Mammalia Sfi1 35
  • 76.22 (n)
  • 65.83 (a)
Sfi1 16
Sfi1 36
  • 65 (a)
(Pan troglodytes)
Mammalia SFI1 35
  • 99.14 (n)
  • 98.55 (a)
SFI1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Sfi1 35
  • 75.78 (n)
  • 65.72 (a)
(Monodelphis domestica)
Mammalia SFI1 36
  • 45 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 45 (a)
-- 36
  • 55 (a)
-- 36
  • 59 (a)
(Gallus gallus)
Aves SFI1 35
  • 50.03 (n)
  • 38.18 (a)
SFI1 36
  • 39 (a)
(Anolis carolinensis)
Reptilia SFI1 36
  • 32 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sfi1 35
  • 49.77 (n)
  • 37.42 (a)
(Danio rerio)
Actinopterygii sfi1 35
  • 43.42 (n)
  • 29.23 (a)
sfi1 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 8 (a)
Species with no ortholog for SFI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SFI1 Gene

Gene Tree for SFI1 (if available)
Gene Tree for SFI1 (if available)

Paralogs for SFI1 Gene

No data available for Paralogs for SFI1 Gene

Variants for SFI1 Gene

Sequence variations from dbSNP and Humsavar for SFI1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs5749290 - 31,508,322(+) AAGCC(A/T)CAATT nc-transcript-variant, reference, missense, utr-variant-5-prime
rs16989698 - 31,528,812(+) GTATC(A/G/T)TGGCA intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime
rs7511430 - 31,550,305(+) CGTCA(G/T)CAGCA nc-transcript-variant, reference, missense
rs5753700 - 31,575,272(+) AGATA(C/T)ACTTC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs16989291 - 31,575,296(+) AGGCC(C/T)GGGAG nc-transcript-variant, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SFI1 Gene

Variant ID Type Subtype PubMed ID
nsv483006 CNV Gain 15286789
esv2663679 CNV Deletion 23128226
nsv914978 CNV Loss 21882294
nsv3594 CNV Insertion 18451855
esv1038327 CNV Deletion 17803354
esv2724141 CNV Deletion 23290073
nsv914979 CNV Loss 21882294
nsv914980 CNV Loss 21882294
nsv517534 CNV Loss 19592680
esv1626782 CNV Deletion 17803354
esv1485049 CNV Deletion 17803354
esv1430494 CNV Deletion 17803354
esv2724142 CNV Deletion 23290073
nsv829176 CNV Loss 20364138
esv268751 CNV Insertion 20981092

Variation tolerance for SFI1 Gene

Residual Variation Intolerance Score: 95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.66; 98.64% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SFI1 Gene

Disorders for SFI1 Gene

Relevant External Links for SFI1

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SFI1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SFI1 Gene

Publications for SFI1 Gene

  1. Sfi1p has conserved centrin-binding sites and an essential function in budding yeast spindle pole body duplication. (PMID: 14504268) Kilmartin J.V. (J. Cell Biol. 2003) 2 3 4 67
  2. Structure, dynamics and thermodynamics of the human centrin 2/hSfi1 complex. (PMID: 19857500) Martinez-Sanz J. … Craescu C.T. (J. Mol. Biol. 2010) 2 3
  3. Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment. (PMID: 24939585) Fransen E. … Friedman R.A. (Eur. J. Hum. Genet. 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for SFI1 Gene

Sources for SFI1 Gene