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Aliases for SFI1 Gene

Aliases for SFI1 Gene

  • SFI1 Centrin Binding Protein 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 139 2 3
  • Sfi1 Homolog, Spindle Assembly Associated (Yeast) 2
  • Sfi1 Homolog, Spindle Assembly Associated 3
  • Homolog Of Yeast Sfi1 3
  • Protein SFI1 Homolog 3
  • PPP1R139 3
  • KIAA0542 4
  • HSfi1p 3
  • HSFI1 4
  • PISD 3

External Ids for SFI1 Gene

Previous GeneCards Identifiers for SFI1 Gene

  • GC22P030217
  • GC22P031884
  • GC22P014853

Summaries for SFI1 Gene

GeneCards Summary for SFI1 Gene

SFI1 (SFI1 Centrin Binding Protein) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Organelle biogenesis and maintenance. GO annotations related to this gene include phosphatase binding.

UniProtKB/Swiss-Prot for SFI1 Gene

  • Plays a role in the dynamic structure of centrosome-associated contractile fibers via its interaction with CETN2.

Additional gene information for SFI1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFI1 Gene

Genomics for SFI1 Gene

Regulatory Elements for SFI1 Gene

Enhancers for SFI1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H031623 2.1 VISTA Ensembl ENCODE dbSUPER 15 +139.0 138996 8 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF766 SP3 MXD4 TUG1 PRR14L DEPDC5 SLC5A4 LOC100422292 MORC2 SFI1 DUSP18 RTCB PIK3IP1-AS1
GH22H031226 2 FANTOM5 Ensembl ENCODE dbSUPER 13.7 -258.3 -258280 7 HDGF ATF1 FOXA2 MLX ARNT ARID4B YY1 TCF12 ZNF121 ZNF766 LIMK2 RNF185 SFI1 SELENOM INPP5J LINC01521 PATZ1 PIK3IP1 SMTN ENSG00000202019
GH22H031283 2 FANTOM5 Ensembl ENCODE dbSUPER 13.7 -199.6 -199586 10 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 SFI1 RNU6-1128P RPS17P16 PATZ1 LINC01521 PIK3IP1 RNF185 LIMK2 SMTN DEPDC5
GH22H031214 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.6 -269.2 -269158 9 HDGF FOXA2 ARID4B FEZF1 DMAP1 YY1 ATF7 RUNX3 SP5 REST LIMK2 PLA2G3 RNF185 SFI1 ENSG00000214125 PIK3IP1 EIF4ENIF1 RNU6-1128P GC22M031223
GH22H031247 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14 -237.4 -237424 8 HDGF PKNOX1 MLX ARID4B SIN3A RARA ZNF366 ATF7 THAP11 SP3 LIMK2 SFI1 RNU6-1128P RNF185 PIK3IP1 MORC2 GC22P031249 PPP1R14BP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SFI1 on UCSC Golden Path with GeneCards custom track

Promoters for SFI1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000145361 1212 2201 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143

Genomic Location for SFI1 Gene

Chromosome:
22
Start:
31,488,688 bp from pter
End:
31,618,586 bp from pter
Size:
129,899 bases
Orientation:
Plus strand

Genomic View for SFI1 Gene

Genes around SFI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SFI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SFI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFI1 Gene

Proteins for SFI1 Gene

  • Protein details for SFI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8K8P3-SFI1_HUMAN
    Recommended name:
    Protein SFI1 homolog
    Protein Accession:
    A8K8P3
    Secondary Accessions:
    • A1L373
    • A1L387
    • A2A2L2
    • B1AKL9
    • B5MDB7
    • B7Z1V6
    • B7Z8G3
    • B7ZBE2
    • B7ZBE3
    • O60289
    • Q2TAN8
    • Q5W1B5
    • Q86TK0
    • Q8N4U8
    • Q8N8C1
    • Q8WU14

    Protein attributes for SFI1 Gene

    Size:
    1242 amino acids
    Molecular mass:
    147664 Da
    Quaternary structure:
    • Interacts with CETN2 (via C-terminus).
    SequenceCaution:
    • Sequence=AAI10815.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI29927.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA25468.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH70755.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI23034.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAM13202.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAM14701.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM28334.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAX14857.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAX14858.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAX15240.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAX15241.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SFI1 Gene

    Alternative splice isoforms for SFI1 Gene

neXtProt entry for SFI1 Gene

Post-translational modifications for SFI1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SFI1 Gene

Domains & Families for SFI1 Gene

Gene Families for SFI1 Gene

Protein Domains for SFI1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

A8K8P3

UniProtKB/Swiss-Prot:

SFI1_HUMAN :
  • CETN2-binding regions contains a conserved Trp residue in their C-terminal ends, which seems critical for interaction with CETN2.
  • Belongs to the SFI1 family.
Domain:
  • CETN2-binding regions contains a conserved Trp residue in their C-terminal ends, which seems critical for interaction with CETN2.
Family:
  • Belongs to the SFI1 family.
genes like me logo Genes that share domains with SFI1: view

Function for SFI1 Gene

Molecular function for SFI1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the dynamic structure of centrosome-associated contractile fibers via its interaction with CETN2.

Phenotypes From GWAS Catalog for SFI1 Gene

Gene Ontology (GO) - Molecular Function for SFI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16956364
GO:0019902 phosphatase binding IDA 19389623
genes like me logo Genes that share ontologies with SFI1: view

Phenotypes for SFI1 Gene

genes like me logo Genes that share phenotypes with SFI1: view

Animal Model Products

CRISPR Products

miRNA for SFI1 Gene

miRTarBase miRNAs that target SFI1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SFI1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SFI1 Gene

Localization for SFI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFI1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localized close to the centriole.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SFI1 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 3

Gene Ontology (GO) - Cellular Components for SFI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IEA --
GO:0005814 centriole IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with SFI1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SFI1 Gene

Pathways & Interactions for SFI1 Gene

genes like me logo Genes that share pathways with SFI1: view

Gene Ontology (GO) - Biological Process for SFI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0010389 regulation of G2/M transition of mitotic cell cycle TAS --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0097711 ciliary basal body docking TAS --
genes like me logo Genes that share ontologies with SFI1: view

No data available for SIGNOR curated interactions for SFI1 Gene

Drugs & Compounds for SFI1 Gene

No Compound Related Data Available

Transcripts for SFI1 Gene

Unigene Clusters for SFI1 Gene

Sfi1 homolog, spindle assembly associated (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SFI1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SFI1 Gene

No ASD Table

Relevant External Links for SFI1 Gene

GeneLoc Exon Structure for
SFI1
ECgene alternative splicing isoforms for
SFI1

Expression for SFI1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SFI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SFI1 Gene

This gene is overexpressed in Brain - Cerebellum (x4.3) and Brain - Cerebellar Hemisphere (x4.1).

Protein differential expression in normal tissues from HIPED for SFI1 Gene

This gene is overexpressed in Rectum (64.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SFI1 Gene



NURSA nuclear receptor signaling pathways regulating expression of SFI1 Gene:

SFI1

SOURCE GeneReport for Unigene cluster for SFI1 Gene:

Hs.62209

Evidence on tissue expression from TISSUES for SFI1 Gene

  • Nervous system(4.7)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with SFI1: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SFI1 Gene

Orthologs for SFI1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SFI1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SFI1 33 34
  • 99.14 (n)
dog
(Canis familiaris)
Mammalia SFI1 33 34
  • 82.57 (n)
cow
(Bos Taurus)
Mammalia SFI1 33 34
  • 77.79 (n)
mouse
(Mus musculus)
Mammalia Sfi1 33 16 34
  • 76.22 (n)
rat
(Rattus norvegicus)
Mammalia Sfi1 33
  • 75.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 59 (a)
OneToMany
-- 34
  • 55 (a)
OneToMany
-- 34
  • 45 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SFI1 34
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves SFI1 33 34
  • 50.03 (n)
lizard
(Anolis carolinensis)
Reptilia SFI1 34
  • 32 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sfi1 33
  • 49.77 (n)
zebrafish
(Danio rerio)
Actinopterygii sfi1 33 34
  • 43.42 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 8 (a)
OneToOne
Species where no ortholog for SFI1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SFI1 Gene

ENSEMBL:
Gene Tree for SFI1 (if available)
TreeFam:
Gene Tree for SFI1 (if available)

Paralogs for SFI1 Gene

No data available for Paralogs for SFI1 Gene

Variants for SFI1 Gene

Sequence variations from dbSNP and Humsavar for SFI1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000019587 -- 31,565,988(+) AGACA(G/T)AGATC intron-variant
rs1000081445 -- 31,589,899(+) TATTA(C/T)GAGGA intron-variant
rs1000085234 -- 31,559,715(+) ACAAG(A/G)TCCCA intron-variant
rs1000094774 -- 31,541,423(+) ATGTT(C/T)ATTTC intron-variant
rs1000141351 -- 31,567,302(+) TATAT(A/C)TCATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SFI1 Gene

Variant ID Type Subtype PubMed ID
esv1038327 CNV deletion 17803354
esv1430494 CNV deletion 17803354
esv1485049 CNV deletion 17803354
esv1626782 CNV deletion 17803354
esv2663679 CNV deletion 23128226
esv2724141 CNV deletion 23290073
esv2724142 CNV deletion 23290073
esv3325006 CNV insertion 20981092
esv3568358 CNV loss 25503493
esv3647589 CNV loss 21293372
esv3647590 CNV loss 21293372
nsv1059314 CNV gain 25217958
nsv1060776 CNV gain 25217958
nsv1063634 CNV gain 25217958
nsv1110864 OTHER inversion 24896259
nsv1116955 CNV deletion 24896259
nsv3594 CNV insertion 18451855
nsv517534 CNV loss 19592680
nsv588894 CNV loss 21841781
nsv829176 CNV loss 20364138
nsv953070 CNV deletion 24416366
nsv964622 CNV duplication 23825009

Variation tolerance for SFI1 Gene

Residual Variation Intolerance Score: 95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.66; 98.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SFI1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SFI1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFI1 Gene

Disorders for SFI1 Gene

Relevant External Links for SFI1

Human Genome Epidemiology (HuGE) Navigator
SFI1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SFI1

No disorders were found for SFI1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SFI1 Gene

Publications for SFI1 Gene

  1. Sfi1p has conserved centrin-binding sites and an essential function in budding yeast spindle pole body duplication. (PMID: 14504268) Kilmartin JV (The Journal of cell biology 2003) 2 3 4 60
  2. Structure, dynamics and thermodynamics of the human centrin 2/hSfi1 complex. (PMID: 19857500) Martinez-Sanz J … Craescu CT (Journal of molecular biology 2010) 2 3 60
  3. Binding of human centrin 2 to the centrosomal protein hSfi1. (PMID: 16956364) Martinez-Sanz J … Craescu CT (The FEBS journal 2006) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 60

Products for SFI1 Gene

Sources for SFI1 Gene

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