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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SFI1 Gene

protein-coding   GIFtS: 48
GCID: GC22P031884

Sfi1 homolog, spindle assembly associated (yeast)
  Search for SFI1
in
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 Human Malady Compendium 
Biological research products
for SFI1    

Aliases
for SFI1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sfi1 Homolog, Spindle Assembly Associated (Yeast)1 2     Homolog Of Yeast Sfi12
KIAA05421 3 5     Protein SFI1 Homolog2
PISD1 2     HSFI11
HSfi1p1     

External Ids:    HGNC: 290641   Entrez Gene: 98142   Ensembl: ENSG000001980897   OMIM: 6127655   UniProtKB: A8K8P33   

Export aliases for SFI1 gene to outside databases

Previous GC identifers: GC22P030217 GC22P014853


Summaries
for SFI1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SFI1_HUMAN, A8K8P3
Function: Plays a role in the dynamic structure of centrosome-associated contractile fibers via its interaction with
CETN2




Genomic Views
for SFI1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SFI1 gene promoter:
         Bach1   HOXA9B   HOXA9   Sp1   Lmo2   Meis-1a   Meis-1   Meis-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SFI1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SFI1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SFI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.2

SFI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SFI1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P031884:  view genomic region     (about GC identifiers)

Start:
 31,884,674 bp from pter      End:
 32,014,572 bp from pter
Size:
 129,899 bases      Orientation:
 plus strand

Proteins
for SFI1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SFI1_HUMAN, A8K8P3 (See protein sequence)
Recommended Name: Protein SFI1 homolog  
Size: 1242 amino acids; 147664 Da
Subunit: Interacts with CETN2 (via C-terminus)
Subcellular location: Cytoplasm, cytoskeleton, centrosome, centriole. Note=Localized close to the centriole
Caution: It is uncertain whether Met-1 or Met-24 is the initiator
Sequence caution: Sequence=AAI10815.1; Type=Erroneous initiation; Sequence=AAI29927.1; Type=Erroneous initiation;
Sequence=BAA25468.2; Type=Erroneous initiation; Sequence=CAH70755.2; Type=Erroneous initiation; Sequence=CAI23034.2;
Type=Erroneous initiation; Sequence=CAM13202.2; Type=Erroneous initiation; Sequence=CAM14701.1; Type=Erroneous gene
model prediction; Sequence=CAM28334.2; Type=Erroneous initiation; Sequence=CAX14857.1; Type=Erroneous initiation;
Sequence=CAX14858.1; Type=Erroneous initiation; Sequence=CAX15240.1; Type=Erroneous initiation; Sequence=CAX15241.1;
Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for SFI1:
2K2I (3D)    
Secondary accessions: A1L373 A1L387 A2A2L2 B1AKL9 B5MDB7 B7Z1V6 B7Z8G3 B7ZBE2 B7ZBE3 O60289 Q2TAN8
Q5W1B5 Q86TK0 Q8N4U8 Q8N8C1 Q8WU14
Alternative splicing: 7 isoforms:  A8K8P3-1   A8K8P3-2   A8K8P3-3   A8K8P3-4   A8K8P3-5   A8K8P3-9   A8K8P3-10   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SFI1: NX_A8K8P3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_A8K8P3

    • SFI1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001007468.1  NP_001245254.1  NP_001245255.1  NP_001245256.1  NP_055590.2  

    ENSEMBL proteins: 
     ENSP00000402679   ENSP00000401199   ENSP00000391339   ENSP00000383146   ENSP00000411793  
     ENSP00000383145   ENSP00000430488   ENSP00000389364   ENSP00000405541   ENSP00000398871  
     ENSP00000416931   ENSP00000443025   ENSP00000416469   ENSP00000397148  
    Reactome Protein details: A8K8P3
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Custom Protein Services for SFI1 
    GenScript Custom Purified and Recombinant Proteins Services for SFI1
    Novus Biologicals SFI1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SFI1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005814centriole IEA--
    GO:0005829cytosol TAS--


    SFI1 for ontologies           About GeneDecksing



    SFI1 Antibody Products: 
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    Search for Antibodies for SFI1 at Abcam  
    Uscn Antibodies for SFI1
    Search ThermoFisher Antibodies for SFI1

    Assay Products for SFI1: 
    Browse Kits and Assays available from EMD Millipore
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    Uscn ELISAs and CLIAs for SFI1

    Protein Domains /
    Families
    for SFI1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: A8K8P3

    UniProtKB/Swiss-Prot: SFI1_HUMAN, A8K8P3
    Domain: CETN2-binding regions contains a conserved Trp residue in their C-terminal ends, which seems critical for
    interaction with CETN2
    Similarity: Belongs to the SFI1 family
    Similarity: Contains 6 HAT repeats


    Function
    for SFI1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SFI1_HUMAN, A8K8P3
    Function: Plays a role in the dynamic structure of centrosome-associated contractile fibers via its interaction with
    CETN2

    miRNA
    Products:            		miRTarBase miRNAs that target SFI1:
    hsa-mir-16 (MIRT001431)

    OriGene 3'-UTR Clone (see all 2): SFI1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SFI1
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate SFI1:
    hsa-miR-579 hsa-miR-203 hsa-miR-4254 hsa-miR-302f hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmid: SFI1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SFI1 (see all 4)
    OriGene shRNA RFP: SFI1
    OriGene siRNA: SFI1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SFI1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SFI1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SFI1 (see all 4)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SFI1 (NM_014775)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SFI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFI1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SFI1
    Search LifeMap BioReagents cell lines for SFI1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFI1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19389623
    GO:0019902phosphatase binding IDA19389623


    SFI1 for ontologies           About GeneDecksing



    Pathways & Interactions
    for SFI1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Recruitment of mitotic centrosome proteins and complexes
    		Centrosome maturation1.00
    		Mitotic G2-G2/M phases0.81
    		Recruitment of mitotic centrosome proteins and complexes1.00
    		Loss of proteins required for interphase microtubule organization from the centrosome0.78
    		G2/M Transition0.83
    		Loss of Nlp from mitotic centrosomes0.78
    2Cell Cycle
    		Cell Cycle1.00
    		Cell Cycle, Mitotic0.84

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/8        Reactome Pathways for SFI1 (see all 8)
        Centrosome maturation
    Cell Cycle
    Recruitment of mitotic centrosome proteins and complexes
    G2/M Transition
    Loss of proteins required for interphase microtubule organization from the centrosome



    SFI1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SFI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/62 Interacting proteins for SFI1 (A8K8P31, 3 ENSP000003831454) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CETN2P412081, 3, ENSP000003593004EBI-2803099,EBI-1789926 I2D: score=4 STRING: ENSP00000359300
    RADILQ96JH83, ENSP000003824924I2D: score=4 STRING: ENSP00000382492
    CDC5LQ994593, ENSP000003605324I2D: score=1 STRING: ENSP00000360532
    KRT19P087273, ENSP000003551244I2D: score=4 STRING: ENSP00000355124
    MDFIQ997503, ENSP000002303214I2D: score=4 STRING: ENSP00000230321
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0010923negative regulation of phosphatase activity IDA19389623


    SFI1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SFI1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SFI1
    Search CenterWatch for drugs/clinical trials and news about SFI1 

    Transcripts
    for SFI1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SFI1 gene (5 alternative transcripts): 
    NM_001007467.2  NM_001258325.1  NM_001258326.1  NM_001258327.1  NM_014775.3  

    Unigene Cluster for SFI1:

    Sfi1 homolog, spindle assembly associated (yeast)
    Hs.62209  [show with all ESTs]
    Unigene Representative Sequence: NM_001007467
    18/31 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31):
    ENST00000465646 ENST00000432498(uc003ale.3 uc003alf.3 uc011alq.2)
    ENST00000443011 ENST00000465437 ENST00000411518 ENST00000400289(uc010gwi.3)
    ENST00000444859 ENST00000400288 ENST00000382162 ENST00000524296 ENST00000450787
    ENST00000486708 ENST00000476010 ENST00000484806 ENST00000452250 ENST00000478887
    ENST00000467357 ENST00000417682

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): SFI1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SFI1
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate SFI1:
    hsa-miR-579 hsa-miR-203 hsa-miR-4254 hsa-miR-302f hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmid: SFI1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SFI1 (see all 4)
    OriGene shRNA RFP: SFI1
    OriGene siRNA: SFI1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SFI1
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SFI1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SFI1 (NM_014775)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SFI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SFI1 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SFI1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SFI1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SFI1

    Additional cDNA sequence: 

    AB011114.2 AK055147.1 AK292408.1 AK293987.1 AK303362.1 BC021576.1 BC110814.1 BC129926.1 
    BC129945.1 

    24/27 DOTS entries (see all 27):

    DT.99999996  DT.86854433  DT.97821139  DT.456181  DT.100037354  DT.99965256  DT.100648845  DT.120664312 
    DT.95320956  DT.100037355  DT.120664403  DT.100837469  DT.75181387  DT.97804862  DT.120664227  DT.92441000 
    DT.100830137  DT.120664415  DT.86845325  DT.100799049  DT.120664221  DT.120664305  DT.120664368  DT.95189271 

    24/153 AceView cDNA sequences (see all 153):

    BC033613 BU193643 BM850285 AA909861 BU738445 BM990783 BM264492 BG058708 
    AI425026 BC021576 AI824779 AI806913 AI358343 CA391527 BQ182132 BG221765 
    BI831061 BI962786 BC046221 BC041101 AW469318 H55415 BG767619 AB011114 

    GeneLoc Exon Structure


    Expression
    for SFI1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SFI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCTGCGGGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SFI1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/14 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 14) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbForelimb MyotomeLimb Muscle Progenitor CellsSkeletal Muscle
    LungTracheal CartilageChondrocytesLung
    Skeletal MuscleHyoid Arch MusclesMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMononuclear MyocytesSkeletal Muscle
    BoneRostral Endochondral Facial BonesBone
    BoneRostral Skull Membranous BonesBone
    CartilageCaudal SynchondrosesCartilage
    CartilageChondrocraniumCartilage
    CartilageRostral ChondrocraniumCartilage
    CartilageRostral SynchondrosesCartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SFI1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SFI1

    SOURCE GeneReport for Unigene cluster: Hs.62209
        SABiosciences Custom PCR Arrays for SFI1
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SFI1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SFI1

    Orthologs
    for SFI1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for SFI1 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Sfi11 , 5 Sfi1 homolog, spindle assembly associated (yeast)1, 5 76.22(n)1
    65.83(a)1    		   11 (2.19 cM)5
    788871  NM_030207.21  NP_084483.21 
     31318505 
    chicken
    (Gallus gallus)    		 Aves SFI11 Sfi1 homolog, spindle assembly associated (yeast) 50.21(n)
    38.96(a)    		   427706  XM_425281.3  XP_425281.3 
    lizard
    (Anolis carolinensis)    		 Reptilia SFI16
    		 --
    		 33(a)
    		 1 ↔ 1
    		 3(143107722-143128413)
    zebrafish
    (Danio rerio)    		 Actinopterygii sfi11 Sfi1 homolog, spindle assembly associated (yeast) 43.83(n)
    29.56(a)    		   560147  XM_683537.4  XP_688629.4 


    ENSEMBL Gene Tree for SFI1 (if available)
    TreeFam Gene Tree for SFI1 (if available) 

    Paralogs
    for SFI1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for SFI1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2239 NCBI SNPs in SFI1 are shown (see all 2239)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1135502111,2
    		C,--14886525(+) GAGGCC/TGAGGC 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1380292771,2
    		--31890155(+) CTAGAA/TACCCA 5 -- us2k10--------
    rs2004739251,2
    		C--31890299(+) CTTAGA/TTTTTT 5 -- us2k10--------
    rs113760641,2
    		C--31890300(+) GATTTT/-TTTTT 5 -- us2k1 trp31Minor allele frequency- -:0.00NA 2
    rs1909207891,2
    		--31890326(+) AGTCTC/TGCTCT 5 -- us2k10--------
    rs1137756591,2
    		C,--31890478(+) TTAGTA/GGTAGA 5 -- us2k12Minor allele frequency- G:0.06WA 120
    rs96092951,2
    		C,F,A,--31890577(+) TAGGCG/ATGAGC 5 -- us2k12Minor allele frequency- A:0.50NA 4
    rs96192021,2
    		C,F,H,--31890765(+) TACTAT/CTATCT 5 -- us2k18Minor allele frequency- C:0.03NS EA NA 1064
    rs574949131,2
    		C,--31891053(+) TTAAAACT/-ACTTG 5 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1152244861,2
    		--31891155(+) ATTATC/TGAGAC 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for SFI1 (31884674 - 32014572 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for SFI1
         4 CNVs: 50851 50850 0236 50849
         4 Indels: 27037 27036 27034 27035

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    Disorders / Diseases
    for SFI1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SFI1 for disorders           About MalaCards

    SFI1 for disorders           About GeneDecksing

    OMIM gene information: 612765    OMIM disorders: --

    Human Genome Epidemiology (HuGE) Navigator: SFI1 (1 document)

    Export disorders for SFI1 gene to outside databases

    Publications
    for SFI1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SFI1 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with SFI1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Sfi1p has conserved centrin-binding sites and an essential function in budding yeast spindle pole body duplication. (PubMed id 14504268)1, 2, 3 Kilmartin J.V. (2003)
    2. Binding of human centrin 2 to the centrosomal protein hSfi1. (PubMed id 16956364)1, 2 Martinez-Sanz J....Craescu C.T. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (1998)
    5. Structure, dynamics and thermodynamics of the human c entrin 2/hSfi1 complex. (PubMed id 19857500)1 Martinez-Sanz J....Craescu C.T. (2010)
    6. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PubMed id 19389623)1 Hendrickx A.... Bollen M. (2009)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation. (PubMed id 16462731)1 Petretti C....Giet R. (2006)
    9. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    10. Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. (PubMed id 16009131)1 Carroll J.S....Brown M. (2005)

    External Searches for SFI1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing SFI1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9814 HGNC: 29064 AceView: SFI1 Ensembl:ENSG00000198089 euGenes: HUgn9814
    ECgene: SFI1 H-InvDB: SFI1

    Other Databases showing SFI1 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0542

    Specialized Databases showing SFI1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SFI1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SFI1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SFI1 gene:
    Search GeneIP for patents involving SFI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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