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Aliases & Descriptions for SF4
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DKFZp434E2216 1, 2 | | F23858 1, 2 | | RBP 1, 2 |
| | | Descriptions |
|---|
| RNA-binding protein 2 | | RNA-binding protein RBP 3 | | splicing factor 4 2 |
|
| | Search outside databases for aliases for SF4 genePrevious GC identifers: GC19M019778 GC19M019232 GC19M019248 |
Summaries for SF4(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for SF4: SF4 is a member of the SURP family of splicing factors.[supplied by OMIM] UniProtKB/Swiss-Prot: SF04_HUMAN, Q8IWZ8Function: Plays a role in premRNA splicing |
Genomic Location for SF4
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the SF4 gene 
Entrez Gene cytogenetic band: 19p13.11 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13SF4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M019247:
(about GC identifiers)
Start:
|
19,248,322 bp from pter |
End:
|
19,292,318 bp from pter |
Size:
|
43,997 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011295.10
| Proteins for SF4
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: SF04_HUMAN, Q8IWZ8 (See
protein sequence)Recommended Name: Splicing factor 4 Size: 645 amino acids; 72471 Da
Subunit: Component of the spliceosome
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAC08052.1; Type=Erroneous gene model prediction;
Secondary accessions: O60378 Q6P3X9 Q8TCQ4 Q8WWT4 Q8WWT5 Q9NTG3Alternative splicing: 2 isoforms: Q8IWZ8-1 Q8IWZ8-2 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_757386.2
ENSEMBL proteins: ENSP00000247001 ENSP00000334032
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for SF4: Assays for SF4: | Protein
Domains/ Families for SF4(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q8IWZ8
ProtoNet protein and cluster: Q8IWZ8 1 Blocks protein family: IPB000467 D111/G-patch domain
UniProtKB/Swiss-Prot: SF04_HUMAN, Q8IWZ8Similarity: Contains 1 G-patch domainSimilarity: Contains 2 SURP motif repeats | Gene Function for SF4
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_172231
Applied Biosystems Silencer® siRNAs for SF4
Sigma-Aldrich siRNA for SF4  Sigma-Aldrich shRNA for SF4  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_172231                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_172231                                  untagged cDNA clones in CMV expression vector (see all 2): NM_172231 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_172231
UniProtKB/Swiss-Prot: SF04_HUMAN, Q8IWZ8Function: Plays a role in premRNA splicing1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003723 | RNA binding |
IEA | -- | About this table | Pathways & Interactions for SF4
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/108 Interacting proteins for SF4 (ENSP000002470013 Q8IWZ82) via UniProtKB, MINT, and/or STRING (see all 108
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for SF4(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for SF4
|
Transcripts for SF4(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_172231
Sigma-Aldrich siRNA for SF4  Sigma-Aldrich shRNA for SF4  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_172231 REFSEQ mRNAs for SF4 gene: NM_172231.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_172231               OriGene GFP tagged cDNA clone in CMV expression vector: NM_172231                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_172231                                  untagged cDNA clones in CMV expression vector (see all 2): NM_172231  Additional cDNA sequence: AF521128.1 AK092745.1 AK292085.1 AK294618.1 AK301119.1 AL137286.1 AL713757.1 AY072916.1 AY072917.1 BC001043.2 BC002986.1 BC063784.1 BC119728.1 BC119729.1 BC142988.1 CR593392.1 CR606492.1 CR607324.1 20 DOTS entries: DT.92434968 DT.100811580 DT.100811589 DT.102836428 DT.95075334 DT.121492546 DT.121492886 DT.121492969 DT.100811584 DT.92001136 DT.95240652 DT.100811588 DT.102836427 DT.121492639 DT.121492800 DT.121492887 DT.95198640 DT.100811583 DT.120832029 DT.121492814 24/216 AceView cDNA sequences (see all 216
):AK092745 CB155043 CD359220 BU781590 BI768177 BG109463 BQ956578 AY072916 CB851075 AL713757 BU786735 BE745790 BU944141 AW411453 AW016900 AI380613 BQ016564 BM919744 BF916638 BU177538 BU517220 BF197124 NM_182812 BG675979
highest scoring ESTs for SF4:AA853264 AF521128 AL544632 AL710749 AL711255 AW674363 AY072916 AY072917 BC063784 BF346065 Unigene Cluster for SF4: Splicing factor 4 Hs.515274 [show with all ESTs]Unigene Representative Sequence: AY072916
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SF4 (see all 6
)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | |
| SP1: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for SF4
2 Ensembl transcripts including schematic representations: ENST00000247001
ENST00000334782
|
Expression for SF4
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| SF4 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for SF4
1 / 2 / 3 5 probe-sets matching SF4 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GAGATGGATA
SOURCE GeneReport for Unigene cluster: Hs.515274
Expression variation in blood from EXPOLDB for SF4 UniProtKB/Swiss-Prot: SF04_HUMAN, Q8IWZ8Tissue specificity: Detected in adult testis and heart, and in adult and fetal brain, kidney and skeletal muscle |
Orthologs for SF4
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for SF4 gene from 5/12 species (see all 12
)
About this table Species with no ortholog for SF4
ENSEMBL Gene Tree for SF4 | Paralogs for SF4(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for SF4 gene
- SFRS142
|
SNPs/Variants for SF4(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for SF4 (up to first 250kb)
|
Disorders & Mutations for SF4
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 607992
|
Medical News for SF4(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for SF4 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/32 PubMed articles for SF4 gene (see all 32
):- SF4 and SFRS14, two related putative splicing factors on human chromosome 19p13.11. (PubMed id 12594045)1, 2, 3, 4 Sampson N.D. and Hewitt J.E. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)3, 4 Grimwood J.... Lucas S.M. (2004)
- Large-scale proteomic analysis of the human spliceosome. (PubMed id 12176931)3, 4 Rappsilber J.... Mann M. (2002)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)3 Barbe L....Andersson-Svahn H. (2008)
- The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)4 Bechtel S....Schupp I. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3 Ota T....Sugano S. (2004)
- Comprehensive proteomic analysis of the human spliceosome. (PubMed id 12226669)3 Zhou Z.... Reed R. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for SF4
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SF4
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing SF4
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SF4(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for SF4(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for SF4:

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Incremental update: 13 Oct 2009
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